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Aliases for SPINT1 Gene

Aliases for SPINT1 Gene

  • Serine Peptidase Inhibitor, Kunitz Type 1 2 3
  • Hepatocyte Growth Factor Activator Inhibitor Type 1 3 4
  • Serine Protease Inhibitor, Kunitz Type 1 2 3
  • HAI-1 3 4
  • HAI1 3 4
  • MANSC2 3
  • HAI 3

External Ids for SPINT1 Gene

Previous GeneCards Identifiers for SPINT1 Gene

  • GC15P036503
  • GC15P034031
  • GC15P038715
  • GC15P038852
  • GC15P038923
  • GC15P041136
  • GC15P017956

Summaries for SPINT1 Gene

Entrez Gene Summary for SPINT1 Gene

  • The protein encoded by this gene is a member of the Kunitz family of serine protease inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for SPINT1 Gene

SPINT1 (Serine Peptidase Inhibitor, Kunitz Type 1) is a Protein Coding gene. Among its related pathways are Transcriptional misregulation in cancer and CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF). GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is LRP11.

UniProtKB/Swiss-Prot for SPINT1 Gene

  • Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14)

Gene Wiki entry for SPINT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPINT1 Gene

Genomics for SPINT1 Gene

Regulatory Elements for SPINT1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SPINT1 Gene

Chromosome:
15
Start:
40,844,018 bp from pter
End:
40,858,207 bp from pter
Size:
14,190 bases
Orientation:
Plus strand

Genomic View for SPINT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPINT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPINT1 Gene

Proteins for SPINT1 Gene

  • Protein details for SPINT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43278-SPIT1_HUMAN
    Recommended name:
    Kunitz-type protease inhibitor 1
    Protein Accession:
    O43278
    Secondary Accessions:
    • Q7Z7D2

    Protein attributes for SPINT1 Gene

    Size:
    529 amino acids
    Molecular mass:
    58398 Da
    Quaternary structure:
    • Interacts with HGFAC.

    Three dimensional structures from OCA and Proteopedia for SPINT1 Gene

    Alternative splice isoforms for SPINT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPINT1 Gene

Proteomics data for SPINT1 Gene at MOPED

Post-translational modifications for SPINT1 Gene

  • Glycosylation at Asn 66, Asn 235, and Asn 523
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for SPINT1 Gene

Domains & Families for SPINT1 Gene

Suggested Antigen Peptide Sequences for SPINT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43278

UniProtKB/Swiss-Prot:

SPIT1_HUMAN :
  • This inhibitor contains two inhibitory domains
Domain:
  • This inhibitor contains two inhibitory domains
  • Contains 2 BPTI/Kunitz inhibitor domains.
  • Contains 1 LDL-receptor class A domain.
  • Contains 1 MANSC domain.
genes like me logo Genes that share domains with SPINT1: view

No data available for Gene Families for SPINT1 Gene

Function for SPINT1 Gene

Molecular function for SPINT1 Gene

UniProtKB/Swiss-Prot Function:
Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14)

Gene Ontology (GO) - Molecular Function for SPINT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SPINT1: view
genes like me logo Genes that share phenotypes with SPINT1: view

Animal Models for SPINT1 Gene

MGI Knock Outs for SPINT1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPINT1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for SPINT1 Gene

Localization for SPINT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPINT1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPINT1 Gene COMPARTMENTS Subcellular localization image for SPINT1 gene
Compartment Confidence
extracellular 5
cytosol 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for SPINT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 9045658
GO:0005615 extracellular space IDA 16502470
GO:0005886 plasma membrane IEA --
GO:0016020 membrane TAS 9045658
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SPINT1: view

Pathways & Interactions for SPINT1 Gene

genes like me logo Genes that share pathways with SPINT1: view

Pathways by source for SPINT1 Gene

1 KEGG pathway for SPINT1 Gene
1 GeneGo (Thomson Reuters) pathway for SPINT1 Gene

Gene Ontology (GO) - Biological Process for SPINT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001843 neural tube closure IEA --
GO:0001892 embryonic placenta development --
GO:0010951 negative regulation of endopeptidase activity TAS 9045658
GO:0030198 extracellular matrix organization IEA --
GO:0060670 branching involved in labyrinthine layer morphogenesis IEA --
genes like me logo Genes that share ontologies with SPINT1: view

No data available for SIGNOR curated interactions for SPINT1 Gene

Drugs & Compounds for SPINT1 Gene

(4) Drugs for SPINT1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Suramin Approved Pharma Activator 18
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 453
serine Nutra 420
tyrosine Nutra 547

(1) Additional Compounds for SPINT1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
LIPID
genes like me logo Genes that share compounds with SPINT1: view

Transcripts for SPINT1 Gene

Unigene Clusters for SPINT1 Gene

Serine peptidase inhibitor, Kunitz type 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPINT1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPINT1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b · 12c
SP1: - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - -
SP5: -
SP6: - - -
SP7:
SP8:
SP9: -

Relevant External Links for SPINT1 Gene

GeneLoc Exon Structure for
SPINT1
ECgene alternative splicing isoforms for
SPINT1

Expression for SPINT1 Gene

mRNA expression in normal human tissues for SPINT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPINT1 Gene

This gene is overexpressed in Esophagus - Mucosa (x8.6), Minor Salivary Gland (x5.8), Skin - Sun Exposed (Lower leg) (x4.8), Skin - Not Sun Exposed (Suprapubic) (x4.4), and Colon - Transverse (x4.2).

Protein differential expression in normal tissues from HIPED for SPINT1 Gene

This gene is overexpressed in Amniocyte (22.8) and Cervix (22.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPINT1 Gene



SOURCE GeneReport for Unigene cluster for SPINT1 Gene Hs.233950

genes like me logo Genes that share expression patterns with SPINT1: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SPINT1 Gene

Orthologs for SPINT1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPINT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SPINT1 35
  • 85.21 (n)
  • 81.85 (a)
SPINT1 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPINT1 35
  • 86.87 (n)
  • 84 (a)
SPINT1 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spint1 35
  • 82.25 (n)
  • 80.67 (a)
Spint1 16
Spint1 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SPINT1 35
  • 99.62 (n)
  • 100 (a)
SPINT1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spint1 35
  • 79.95 (n)
  • 77.32 (a)
oppossum
(Monodelphis domestica)
Mammalia SPINT1 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPINT1 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPINT1 35
  • 65.08 (n)
  • 56.4 (a)
SPINT1 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPINT1 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spint1 35
  • 57.98 (n)
  • 50 (a)
zebrafish
(Danio rerio)
Actinopterygii spint1b 35
  • 51.44 (n)
  • 42.57 (a)
spint1a 36
  • 35 (a)
OneToMany
spint1b 36
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3864 36
  • 19 (a)
OneToMany
Species with no ortholog for SPINT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPINT1 Gene

ENSEMBL:
Gene Tree for SPINT1 (if available)
TreeFam:
Gene Tree for SPINT1 (if available)

Paralogs for SPINT1 Gene

Paralogs for SPINT1 Gene

(5) SIMAP similar genes for SPINT1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SPINT1: view

Variants for SPINT1 Gene

Sequence variations from dbSNP and Humsavar for SPINT1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs536990848 -- 40,856,240(+) GCCCT(C/T)AGTAC intron-variant
rs541901086 -- 40,852,281(+) TTGTC(A/G)TTGGA intron-variant
rs542018844 -- 40,854,191(+) CCCCT(C/G)AGAGT intron-variant
rs542424206 -- 40,851,850(+) ACCCC(A/G)TCTCT intron-variant
rs542521692 -- 40,857,278(+) CTACC(C/T)CATGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SPINT1 Gene

Variant ID Type Subtype PubMed ID
nsv904101 CNV Loss 21882294
nsv904102 CNV Loss 21882294
dgv2360n71 CNV Loss 21882294
nsv904104 CNV Loss 21882294

Variation tolerance for SPINT1 Gene

Residual Variation Intolerance Score: 80.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.15; 69.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPINT1 Gene

HapMap Linkage Disequilibrium report
SPINT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPINT1 Gene

Disorders for SPINT1 Gene

Relevant External Links for SPINT1

Genetic Association Database (GAD)
SPINT1
Human Genome Epidemiology (HuGE) Navigator
SPINT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPINT1
genes like me logo Genes that share disorders with SPINT1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPINT1 Gene

Publications for SPINT1 Gene

  1. Hepatocyte growth factor activation inhibitors - therapeutic potential in cancer. (PMID: 20015004) Parr C. … Jiang W.G. (Anticancer Agents Med Chem 2010) 23 67
  2. Hepatocyte growth factor activator (HGFA): molecular structure and interactions with HGFA inhibitor-1 (HAI-1). (PMID: 20402765) Eigenbrot C. … Kirchhofer D. (FEBS J. 2010) 23 67
  3. Matriptase activation, an early cellular response to acidosis. (PMID: 19940125) Tseng I.C. … Lin C.Y. (J. Biol. Chem. 2010) 23 67
  4. Tumor detection by imaging proteolytic activity. (PMID: 20145119) Darragh M.R. … Craik C.S. (Cancer Res. 2010) 23 67
  5. Polarized epithelial cells secrete matriptase as a consequence of zymogen activation and HAI-1-mediated inhibition. (PMID: 19535514) Wang J.K. … Lin C.Y. (Am. J. Physiol., Cell Physiol. 2009) 23 67

Products for SPINT1 Gene

Sources for SPINT1 Gene

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