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Aliases for SPINT1 Gene

Aliases for SPINT1 Gene

  • Serine Peptidase Inhibitor, Kunitz Type 1 2 3
  • Hepatocyte Growth Factor Activator Inhibitor Type 1 3 4
  • Serine Protease Inhibitor, Kunitz Type 1 2 3
  • HAI-1 3 4
  • HAI1 3 4
  • Kunitz-Type Protease Inhibitor 1 3
  • MANSC2 3
  • HAI 3

External Ids for SPINT1 Gene

Summaries for SPINT1 Gene

Entrez Gene Summary for SPINT1 Gene

  • The protein encoded by this gene is a member of the Kunitz family of serine protease inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for SPINT1 Gene

SPINT1 (Serine Peptidase Inhibitor, Kunitz Type 1) is a Protein Coding gene. Diseases associated with SPINT1 include prostate cancer. Among its related pathways are Transcriptional misregulation in cancer and CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF). GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is LRP11.

UniProtKB/Swiss-Prot for SPINT1 Gene

  • Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14)

Gene Wiki entry for SPINT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPINT1 Gene

Genomics for SPINT1 Gene

Genomic Location for SPINT1 Gene

40,844,018 bp from pter
40,858,207 bp from pter
14,190 bases
Plus strand

Genomic View for SPINT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPINT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPINT1 Gene

Regulatory Elements for SPINT1 Gene

Proteins for SPINT1 Gene

  • Protein details for SPINT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kunitz-type protease inhibitor 1
    Protein Accession:
    Secondary Accessions:
    • Q7Z7D2

    Protein attributes for SPINT1 Gene

    529 amino acids
    Molecular mass:
    58398 Da
    Quaternary structure:
    • Interacts with HGFAC.

    Three dimensional structures from OCA and Proteopedia for SPINT1 Gene

    Alternative splice isoforms for SPINT1 Gene


neXtProt entry for SPINT1 Gene

Proteomics data for SPINT1 Gene at MOPED

Post-translational modifications for SPINT1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn66, Asn235, and Asn523

No data available for DME Specific Peptides for SPINT1 Gene

Domains for SPINT1 Gene


  • This inhibitor contains two inhibitory domains:
    • O43278
  • Contains 2 BPTI/Kunitz inhibitor domains.:
    • O43278
  • Contains 1 LDL-receptor class A domain.:
    • O43278
  • Contains 1 MANSC domain.:
    • O43278
genes like me logo Genes that share domains with SPINT1: view

No data available for Gene Families for SPINT1 Gene

Function for SPINT1 Gene

Molecular function for SPINT1 Gene

UniProtKB/Swiss-Prot Function: Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14)

Gene Ontology (GO) - Molecular Function for SPINT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SPINT1: view
genes like me logo Genes that share phenotypes with SPINT1: view

Animal Models for SPINT1 Gene

MGI Knock Outs for SPINT1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SPINT1 Gene

Localization for SPINT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPINT1 Gene


Subcellular locations from

Jensen Localization Image for SPINT1 Gene COMPARTMENTS Subcellular localization image for SPINT1 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SPINT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 9045658
GO:0005615 extracellular space IDA 16502470
GO:0016020 membrane TAS 9045658
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SPINT1: view

Pathways for SPINT1 Gene

genes like me logo Genes that share pathways with SPINT1: view

Pathways by source for SPINT1 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for SPINT1 Gene
1 KEGG pathway for SPINT1 Gene

Gene Ontology (GO) - Biological Process for SPINT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001892 embryonic placenta development --
GO:0010951 negative regulation of endopeptidase activity TAS 9045658
GO:0030198 extracellular matrix organization IEA --
GO:0060670 branching involved in labyrinthine layer morphogenesis IEA --
GO:0060674 placenta blood vessel development IEA --
genes like me logo Genes that share ontologies with SPINT1: view

Compounds for SPINT1 Gene

(5) Novoseek inferred chemical compound relationships for SPINT1 Gene

Compound -log(P) Hits PubMed IDs
serine 76.7 41
suramin 40.8 2
lipid 0 1
tyrosine 0 1
testosterone 0 3
genes like me logo Genes that share compounds with SPINT1: view

Transcripts for SPINT1 Gene

Unigene Clusters for SPINT1 Gene

Serine peptidase inhibitor, Kunitz type 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPINT1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b · 12c
SP1: - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - -
SP5: -
SP6: - - -
SP9: -

Relevant External Links for SPINT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPINT1 Gene

mRNA expression in normal human tissues for SPINT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPINT1 Gene

This gene is overexpressed in Esophagus - Mucosa (8.6), Minor Salivary Gland (5.8), Skin - Sun Exposed (Lower leg) (4.8), Skin - Not Sun Exposed (Suprapubic) (4.4), and Colon - Transverse (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPINT1 Gene

SOURCE GeneReport for Unigene cluster for SPINT1 Gene Hs.233950

genes like me logo Genes that share expressions with SPINT1: view

Orthologs for SPINT1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPINT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPINT1 36
  • 99.62 (n)
  • 100 (a)
  • 100 (a)
(Bos Taurus)
Mammalia SPINT1 36
  • 85.21 (n)
  • 81.85 (a)
  • 80 (a)
(Canis familiaris)
Mammalia SPINT1 36
  • 86.87 (n)
  • 84 (a)
  • 83 (a)
(Mus musculus)
Mammalia Spint1 36
  • 82.25 (n)
  • 80.67 (a)
Spint1 16
Spint1 37
  • 80 (a)
(Monodelphis domestica)
Mammalia SPINT1 37
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia SPINT1 37
  • 61 (a)
(Rattus norvegicus)
Mammalia Spint1 36
  • 79.95 (n)
  • 77.32 (a)
(Gallus gallus)
Aves SPINT1 36
  • 65.08 (n)
  • 56.4 (a)
  • 48 (a)
(Anolis carolinensis)
Reptilia SPINT1 37
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia spint1 36
  • 57.98 (n)
  • 50 (a)
(Danio rerio)
Actinopterygii spint1a 37
  • 35 (a)
spint1b 36
  • 51.44 (n)
  • 42.57 (a)
spint1b 37
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3864 37
  • 19 (a)
Species with no ortholog for SPINT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPINT1 Gene

Gene Tree for SPINT1 (if available)
Gene Tree for SPINT1 (if available)

Paralogs for SPINT1 Gene

Paralogs for SPINT1 Gene

Selected SIMAP similar genes for SPINT1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SPINT1: view

Variants for SPINT1 Gene

Sequence variations from dbSNP and Humsavar for SPINT1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs17649 -- 40,857,481(-) GAGGA(A/C/G/T)AGAGA utr-variant-3-prime
rs582639 -- 40,851,818(+) gagtt(C/G)aagac intron-variant
rs583031 -- 40,851,878(+) tagcc(A/G)ggcat intron-variant
rs643875 -- 40,854,895(+) CCAGG(C/T)ATCAC intron-variant
rs647423 -- 40,849,119(+) tgggc(A/G)cctgt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPINT1 Gene

Variant ID Type Subtype PubMed ID
nsv904101 CNV Loss 21882294
nsv904102 CNV Loss 21882294
dgv2360n71 CNV Loss 21882294
nsv904104 CNV Loss 21882294

Relevant External Links for SPINT1 Gene

HapMap Linkage Disequilibrium report

Disorders for SPINT1 Gene

(1) MalaCards Diseases for SPINT1 Gene

Search for SPINT1 Gene in MalaCards »

(18) Novoseek inferred disease relationships for SPINT1 Gene

Disease -log(P) Hits PubMed IDs
carcinoma 38.2 11
cancer 32.5 22
prostatic adenocarcinoma 28.1 1
breast cancer 24.1 16
colorectal carcinoma 23.1 4

Relevant External Links for SPINT1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SPINT1: view

No data available for UniProtKB/Swiss-Prot for SPINT1 Gene

Publications for SPINT1 Gene

  1. Matriptase and HAI-1 are expressed by normal and malignant epithelial cells in vitro and in vivo. (PMID: 11290548) Oberst M. … Lin C.Y. (Am. J. Pathol. 2001) 3 23
  2. White matter astrocytes produce hepatocyte growth factor activator inhibitor in human brain tissues. (PMID: 9743567) Yamada T. … Shimomura T. (Exp. Neurol. 1998) 3 23
  3. Distribution of hepatocyte growth factor activator inhibitor type 1 (HAI-1) in human tissues. Cellular surface localization of HAI-1 in simple columnar epithelium and its modulated expression in injured and regenerative tissues. (PMID: 10219059) Kataoka H. … Koono M. (J. Histochem. Cytochem. 1999) 3 23
  4. Multiple sites of proteolytic cleavage to release soluble forms of hepatocyte growth factor activator inhibitor type 1 from a transmembrane form. (PMID: 10544273) Shimomura T. … Kitamura N. (J. Biochem. 1999) 3 23
  5. Tissue expression, protease specificity, and Kunitz domain functions of hepatocyte growth factor activator inhibitor-1B (HAI-1B), a new splice variant of HAI-1. (PMID: 12815039) Kirchhofer D. … Moran P. (J. Biol. Chem. 2003) 3 23

Products for SPINT1 Gene

Sources for SPINT1 Gene

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