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Aliases for SPINK9 Gene

Aliases for SPINK9 Gene

  • Serine Peptidase Inhibitor, Kazal Type 9 2 3
  • LEKTI2 3 4 6
  • Lymphoepithelial Kazal-Type-Related Inhibitor 2 3 4
  • Serine Protease Inhibitor Kazal Type 9 3
  • Serine Protease Inhibitor Kazal-Type 9 3

External Ids for SPINK9 Gene

Previous GeneCards Identifiers for SPINK9 Gene

  • GC05P147695
  • GC05P142862

Summaries for SPINK9 Gene

GeneCards Summary for SPINK9 Gene

SPINK9 (Serine Peptidase Inhibitor, Kazal Type 9) is a Protein Coding gene. Diseases associated with SPINK9 include dyshidrosis and fatty liver disease. GO annotations related to this gene include serine-type endopeptidase inhibitor activity.

UniProtKB/Swiss-Prot for SPINK9 Gene

  • Serine protease inhibitor which specifically inhibits KLK5. May contribute to the regulation of the desquamation process in skin by inhibiting KLK5.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPINK9 Gene

Genomics for SPINK9 Gene

Regulatory Elements for SPINK9 Gene

Transcription factor binding sites by QIAGEN in the SPINK9 gene promoter:

Genomic Location for SPINK9 Gene

148,321,203 bp from pter
148,339,849 bp from pter
18,647 bases
Plus strand

Genomic View for SPINK9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPINK9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPINK9 Gene

Proteins for SPINK9 Gene

  • Protein details for SPINK9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine protease inhibitor Kazal-type 9
    Protein Accession:
    Secondary Accessions:
    • B2RPN9

    Protein attributes for SPINK9 Gene

    86 amino acids
    Molecular mass:
    9756 Da
    Quaternary structure:
    • Dimer. Interacts with KLK5 and KLK8.

neXtProt entry for SPINK9 Gene

Proteomics data for SPINK9 Gene at MOPED

Post-translational modifications for SPINK9 Gene

No Post-translational modifications

Other Protein References for SPINK9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPINK9 Gene

Domains for SPINK9 Gene

Gene Families for SPINK9 Gene

  • SPINK :Serine peptidase inhibitors, Kazal type

Protein Domains for SPINK9 Gene

Suggested Antigen Peptide Sequences for SPINK9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q5DT21
  • Contains 1 Kazal-like domain.
genes like me logo Genes that share domains with SPINK9: view

Function for SPINK9 Gene

Molecular function for SPINK9 Gene

UniProtKB/Swiss-Prot Function: Serine protease inhibitor which specifically inhibits KLK5. May contribute to the regulation of the desquamation process in skin by inhibiting KLK5.

Gene Ontology (GO) - Molecular Function for SPINK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IDA 19194479
GO:0005515 protein binding IPI 19194479
genes like me logo Genes that share ontologies with SPINK9: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SPINK9 Gene

Localization for SPINK9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPINK9 Gene


Subcellular locations from

Jensen Localization Image for SPINK9 Gene COMPARTMENTS Subcellular localization image for SPINK9 gene
Compartment Confidence
extracellular 3
nucleus 1

Gene Ontology (GO) - Cellular Components for SPINK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with SPINK9: view

Pathways for SPINK9 Gene

SuperPathways for SPINK9 Gene

No Data Available

Interacting Proteins for SPINK9 Gene

Gene Ontology (GO) - Biological Process for SPINK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with SPINK9: view

No data available for Pathways by source for SPINK9 Gene

Transcripts for SPINK9 Gene

mRNA/cDNA for SPINK9 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPINK9 Gene

Serine peptidase inhibitor, Kazal type 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPINK9 Gene

No ASD Table

Relevant External Links for SPINK9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPINK9 Gene

mRNA expression in normal human tissues for SPINK9 Gene

SOURCE GeneReport for Unigene cluster for SPINK9 Gene Hs.631798

mRNA Expression by UniProt/SwissProt for SPINK9 Gene

Tissue specificity: Skin. Highly expressed at sites of hyperkeratosis. Also detected in thymus, tonsils, testis, pancreas, liver, placenta and brain. Expressed at stratum granulosum and stratum corneum at palmar and plantar sites (at protein level).
genes like me logo Genes that share expressions with SPINK9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein expression for SPINK9 Gene

Orthologs for SPINK9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPINK9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPINK9 35
  • 98.45 (n)
  • 97.67 (a)
  • 64 (a)
(Bos Taurus)
Mammalia SPINK9 35
  • 80.95 (n)
  • 64.29 (a)
(Canis familiaris)
Mammalia SPINK9 35
  • 82.56 (n)
  • 65.12 (a)
  • 74 (a)
(Mus musculus)
Mammalia Spink12 16
(Monodelphis domestica)
Mammalia -- 36
  • 40 (a)
-- 36
  • 45 (a)
Species with no ortholog for SPINK9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPINK9 Gene

Gene Tree for SPINK9 (if available)
Gene Tree for SPINK9 (if available)

Paralogs for SPINK9 Gene

Selected SIMAP similar genes for SPINK9 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SPINK9: view

No data available for Paralogs for SPINK9 Gene

Variants for SPINK9 Gene

Structural Variations from Database of Genomic Variants (DGV) for SPINK9 Gene

Variant ID Type Subtype PubMed ID
nsv883015 CNV Loss 21882294
nsv5058 CNV Insertion 18451855

Relevant External Links for SPINK9 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for SPINK9 Gene

Disorders for SPINK9 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for SPINK9 Gene including...

Search for SPINK9 Gene in MalaCards »

(2) University of Copenhagen DISEASES for SPINK9 Gene

genes like me logo Genes that share disorders with SPINK9: view

No data available for UniProtKB/Swiss-Prot for SPINK9 Gene

Publications for SPINK9 Gene

  1. Identification of lympho-epithelial Kazal-type inhibitor 2 in human skin as a kallikrein-related peptidase 5-specific protease inhibitor. (PMID: 19190773) Meyer-Hoffert U. … Schroeder J.M. (PLoS ONE 2009) 3 4
  2. SPINK9: a selective, skin-specific Kazal-type serine protease inhibitor. (PMID: 19194479) Brattsand M. … Egelrud T. (J. Invest. Dermatol. 2009) 3 4
  3. Common SPINK-1 mutations do not predispose to the development of non-alcoholic fatty liver disease. (PMID: 19502653) Oruc N. … Akarca U.S. (Ann Hepatol 2009) 3
  4. Expression and regulation of murine SPINK12, a potential orthologue of human LEKTI2. (PMID: 21899598) Reiss K. … Sedlacek R. (Exp. Dermatol. 2011) 3
  5. Characterization of SPINK9, a KLK5-specific inhibitor expressed in palmo-plantar epidermis. (PMID: 22505519) BrAonnstrAPm K. … Brattsand M. (Biol. Chem. 2012) 3

Products for SPINK9 Gene

Sources for SPINK9 Gene

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