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Aliases for SPINK9 Gene

Aliases for SPINK9 Gene

  • Serine Peptidase Inhibitor, Kazal Type 9 2 3 5
  • Lymphoepithelial Kazal-Type-Related Inhibitor 2 3 4
  • LEKTI2 3 4

External Ids for SPINK9 Gene

Previous GeneCards Identifiers for SPINK9 Gene

  • GC05P147695
  • GC05P142862

Summaries for SPINK9 Gene

Entrez Gene Summary for SPINK9 Gene

  • The protein encoded by this gene is a Kazal-type serine protease inhibitor that appears to specifically target kallikrein-related peptidase 5 (KLK5) in the palmo-plantar epidermis. KLK5 is an important initiator of skin desquamation, so the encoded protease inhibitor may regulate skin differentiation in the palms of hands and soles of feet. This cationic protein has also been shown to promote keratinocyte migration by activation of the epidermal growth factor receptor (EGFR). [provided by RefSeq, Dec 2015]

GeneCards Summary for SPINK9 Gene

SPINK9 (Serine Peptidase Inhibitor, Kazal Type 9) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity.

UniProtKB/Swiss-Prot for SPINK9 Gene

  • Serine protease inhibitor which specifically inhibits KLK5. May contribute to the regulation of the desquamation process in skin by inhibiting KLK5.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPINK9 Gene

Genomics for SPINK9 Gene

Regulatory Elements for SPINK9 Gene

Enhancers for SPINK9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SPINK9 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SPINK9 gene promoter:

Genomic Location for SPINK9 Gene

Chromosome:
5
Start:
148,321,203 bp from pter
End:
148,339,849 bp from pter
Size:
18,647 bases
Orientation:
Plus strand

Genomic View for SPINK9 Gene

Genes around SPINK9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPINK9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPINK9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPINK9 Gene

Proteins for SPINK9 Gene

  • Protein details for SPINK9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5DT21-ISK9_HUMAN
    Recommended name:
    Serine protease inhibitor Kazal-type 9
    Protein Accession:
    Q5DT21
    Secondary Accessions:
    • B2RPN9

    Protein attributes for SPINK9 Gene

    Size:
    86 amino acids
    Molecular mass:
    9756 Da
    Quaternary structure:
    • Dimer. Interacts with KLK5 and KLK8.

neXtProt entry for SPINK9 Gene

Proteomics data for SPINK9 Gene at MOPED

Post-translational modifications for SPINK9 Gene

No Post-translational modifications

Other Protein References for SPINK9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SPINK9

No data available for DME Specific Peptides for SPINK9 Gene

Domains & Families for SPINK9 Gene

Gene Families for SPINK9 Gene

Protein Domains for SPINK9 Gene

Suggested Antigen Peptide Sequences for SPINK9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5DT21

UniProtKB/Swiss-Prot:

ISK9_HUMAN :
  • Contains 1 Kazal-like domain.
Domain:
  • Contains 1 Kazal-like domain.
genes like me logo Genes that share domains with SPINK9: view

Function for SPINK9 Gene

Molecular function for SPINK9 Gene

UniProtKB/Swiss-Prot Function:
Serine protease inhibitor which specifically inhibits KLK5. May contribute to the regulation of the desquamation process in skin by inhibiting KLK5.

Phenotypes for SPINK9 Gene

genes like me logo Genes that share phenotypes with SPINK9: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPINK9 Gene

Localization for SPINK9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPINK9 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPINK9 Gene COMPARTMENTS Subcellular localization image for SPINK9 gene
Compartment Confidence
extracellular 5

No data available for Gene Ontology (GO) - Cellular Components for SPINK9 Gene

Pathways & Interactions for SPINK9 Gene

SuperPathways for SPINK9 Gene

No Data Available

Interacting Proteins for SPINK9 Gene

Gene Ontology (GO) - Biological Process for SPINK9 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SPINK9 Gene

Drugs & Compounds for SPINK9 Gene

No Compound Related Data Available

Transcripts for SPINK9 Gene

mRNA/cDNA for SPINK9 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPINK9 Gene

Serine peptidase inhibitor, Kazal type 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPINK9 Gene

No ASD Table

Relevant External Links for SPINK9 Gene

GeneLoc Exon Structure for
SPINK9
ECgene alternative splicing isoforms for
SPINK9

Expression for SPINK9 Gene

mRNA expression in normal human tissues for SPINK9 Gene

SOURCE GeneReport for Unigene cluster for SPINK9 Gene Hs.631798

mRNA Expression by UniProt/SwissProt for SPINK9 Gene

Q5DT21-ISK9_HUMAN
Tissue specificity: Skin. Highly expressed at sites of hyperkeratosis. Also detected in thymus, tonsils, testis, pancreas, liver, placenta and brain. Expressed at stratum granulosum and stratum corneum at palmar and plantar sites (at protein level).
genes like me logo Genes that share expression patterns with SPINK9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SPINK9 Gene

Orthologs for SPINK9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPINK9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SPINK9 35
  • 80.95 (n)
  • 64.29 (a)
dog
(Canis familiaris)
Mammalia SPINK9 35
  • 82.56 (n)
  • 65.12 (a)
SPINK9 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SPINK9 35
  • 98.45 (n)
  • 97.67 (a)
SPINK9 36
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 40 (a)
OneToMany
-- 36
  • 45 (a)
OneToMany
Species with no ortholog for SPINK9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPINK9 Gene

ENSEMBL:
Gene Tree for SPINK9 (if available)
TreeFam:
Gene Tree for SPINK9 (if available)

Paralogs for SPINK9 Gene

(8) SIMAP similar genes for SPINK9 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SPINK9: view

No data available for Paralogs for SPINK9 Gene

Variants for SPINK9 Gene

Structural Variations from Database of Genomic Variants (DGV) for SPINK9 Gene

Variant ID Type Subtype PubMed ID
nsv883015 CNV Loss 21882294
nsv5058 CNV Insertion 18451855

Variation tolerance for SPINK9 Gene

Residual Variation Intolerance Score: 75.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.64; 65.62% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for SPINK9 Gene

Disorders for SPINK9 Gene

Relevant External Links for SPINK9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPINK9

No disorders were found for SPINK9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPINK9 Gene

Publications for SPINK9 Gene

  1. Identification of lympho-epithelial Kazal-type inhibitor 2 in human skin as a kallikrein-related peptidase 5-specific protease inhibitor. (PMID: 19190773) Meyer-Hoffert U. … Schroeder J.M. (PLoS ONE 2009) 3 4 67
  2. SPINK9 stimulates metalloprotease/EGFR-dependent keratinocyte migration via purinergic receptor activation. (PMID: 24441102) Sperrhacke M. … Reiss K. (J. Invest. Dermatol. 2014) 3
  3. Characterization of SPINK9, a KLK5-specific inhibitor expressed in palmo-plantar epidermis. (PMID: 22505519) BrAonnstrAPm K. … Brattsand M. (Biol. Chem. 2012) 3
  4. Expression and regulation of murine SPINK12, a potential orthologue of human LEKTI2. (PMID: 21899598) Reiss K. … Sedlacek R. (Exp. Dermatol. 2011) 3
  5. SPINK9: a selective, skin-specific Kazal-type serine protease inhibitor. (PMID: 19194479) Brattsand M. … Egelrud T. (J. Invest. Dermatol. 2009) 3

Products for SPINK9 Gene

Sources for SPINK9 Gene

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