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Aliases for SPINK8 Gene

Aliases for SPINK8 Gene

  • Serine Peptidase Inhibitor, Kazal Type 8 (Putative) 2 3 5

External Ids for SPINK8 Gene

Previous GeneCards Identifiers for SPINK8 Gene

  • GC03M048324

Summaries for SPINK8 Gene

GeneCards Summary for SPINK8 Gene

SPINK8 (Serine Peptidase Inhibitor, Kazal Type 8 (Putative)) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity.

UniProtKB/Swiss-Prot for SPINK8 Gene

  • Probable serine protease inhibitor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPINK8 Gene

Genomics for SPINK8 Gene

Regulatory Elements for SPINK8 Gene

Enhancers for SPINK8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SPINK8 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPINK8 Gene

48,306,842 bp from pter
48,328,341 bp from pter
21,500 bases
Minus strand

Genomic View for SPINK8 Gene

Genes around SPINK8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPINK8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPINK8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPINK8 Gene

Proteins for SPINK8 Gene

  • Protein details for SPINK8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine protease inhibitor Kazal-type 8
    Protein Accession:

    Protein attributes for SPINK8 Gene

    97 amino acids
    Molecular mass:
    10821 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPINK8 Gene

Proteomics data for SPINK8 Gene at MOPED

Post-translational modifications for SPINK8 Gene

Other Protein References for SPINK8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPINK8 Gene

Domains & Families for SPINK8 Gene

Gene Families for SPINK8 Gene

Protein Domains for SPINK8 Gene


Suggested Antigen Peptide Sequences for SPINK8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Kazal-like domain.
  • Contains 1 Kazal-like domain.
genes like me logo Genes that share domains with SPINK8: view

Function for SPINK8 Gene

Molecular function for SPINK8 Gene

UniProtKB/Swiss-Prot Function:
Probable serine protease inhibitor.
genes like me logo Genes that share phenotypes with SPINK8: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPINK8 Gene

Localization for SPINK8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPINK8 Gene


Subcellular locations from

Jensen Localization Image for SPINK8 Gene COMPARTMENTS Subcellular localization image for SPINK8 gene
Compartment Confidence
extracellular 5

No data available for Gene Ontology (GO) - Cellular Components for SPINK8 Gene

Pathways & Interactions for SPINK8 Gene

SuperPathways for SPINK8 Gene

No Data Available

Interacting Proteins for SPINK8 Gene

Gene Ontology (GO) - Biological Process for SPINK8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1900004 negative regulation of serine-type endopeptidase activity IBA --
genes like me logo Genes that share ontologies with SPINK8: view

No data available for Pathways by source and SIGNOR curated interactions for SPINK8 Gene

Drugs & Compounds for SPINK8 Gene

No Compound Related Data Available

Transcripts for SPINK8 Gene

mRNA/cDNA for SPINK8 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPINK8 Gene

Serine peptidase inhibitor, Kazal type 8 (putative):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPINK8 Gene

No ASD Table

Relevant External Links for SPINK8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPINK8 Gene

mRNA expression in normal human tissues for SPINK8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPINK8 Gene

This gene is overexpressed in Whole Blood (x9.0), Esophagus - Mucosa (x6.5), and Brain - Spinal cord (cervical c-1) (x4.7).

SOURCE GeneReport for Unigene cluster for SPINK8 Gene Hs.257687

genes like me logo Genes that share expression patterns with SPINK8: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SPINK8 Gene

Orthologs for SPINK8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPINK8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC101904056 35
  • 77.9 (n)
  • 63.04 (a)
  • 56 (a)
(Canis familiaris)
Mammalia SPINK8 35
  • 78.52 (n)
  • 68.89 (a)
  • 80 (a)
(Mus musculus)
Mammalia Spink8 35
  • 70.1 (n)
  • 56.7 (a)
Spink8 16
Spink8 36
  • 51 (a)
(Pan troglodytes)
Mammalia SPINK8 35
  • 99.66 (n)
  • 98.97 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Spink8 35
  • 73.88 (n)
  • 56.7 (a)
Species with no ortholog for SPINK8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPINK8 Gene

Gene Tree for SPINK8 (if available)
Gene Tree for SPINK8 (if available)

Paralogs for SPINK8 Gene

(2) SIMAP similar genes for SPINK8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPINK8: view

No data available for Paralogs for SPINK8 Gene

Variants for SPINK8 Gene

Sequence variations from dbSNP and Humsavar for SPINK8 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs11718350 - 48,319,502(+) AGAAT(G/T)TTGGA reference, missense
rs4371540 -- 48,312,053(+) TGTGT(A/G)GGCCT intron-variant
rs4380430 -- 48,315,276(+) caaaa(G/T)attca intron-variant
rs4404473 -- 48,312,136(+) CTCCA(A/G)AAAAA intron-variant
rs4420898 -- 48,323,187(+) tcaca(C/T)aggct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPINK8 Gene

Variant ID Type Subtype PubMed ID
nsv834683 CNV Gain 17160897
esv2661878 CNV Deletion 23128226

Variation tolerance for SPINK8 Gene

Residual Variation Intolerance Score: 73.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.06; 75.25% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SPINK8 Gene

Disorders for SPINK8 Gene

Relevant External Links for SPINK8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SPINK8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPINK8 Gene

Publications for SPINK8 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Novel epididymal protease inhibitors with Kazal or WAP family domain. (PMID: 16930550) Jalkanen J. … Poutanen M. (Biochem. Biophys. Res. Commun. 2006) 2 3

Products for SPINK8 Gene

Sources for SPINK8 Gene