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Aliases for SPINK7 Gene

Aliases for SPINK7 Gene

  • Serine Peptidase Inhibitor, Kazal Type 7 (Putative) 2 3
  • Esophagus Cancer-Related Gene 2 Protein 3 4
  • Esophagus Cancer Related Gene 2 2 3
  • ECRG-2 3 4
  • ECG2 3 4
  • Serine Protease Inhibitor Kazal-Type 7 3
  • Esophagus Cancer-Related Gene-2 3
  • ECRG2 3

External Ids for SPINK7 Gene

Previous GeneCards Identifiers for SPINK7 Gene

  • GC05P147673
  • GC05P147691
  • GC05P142839

Summaries for SPINK7 Gene

GeneCards Summary for SPINK7 Gene

SPINK7 (Serine Peptidase Inhibitor, Kazal Type 7 (Putative)) is a Protein Coding gene. Diseases associated with SPINK7 include esophageal cancer. GO annotations related to this gene include serine-type endopeptidase inhibitor activity.

UniProtKB/Swiss-Prot for SPINK7 Gene

  • Probable serine protease inhibitor

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPINK7 Gene

Genomics for SPINK7 Gene

Regulatory Elements for SPINK7 Gene

Genomic Location for SPINK7 Gene

148,312,419 bp from pter
148,315,922 bp from pter
3,504 bases
Plus strand

Genomic View for SPINK7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPINK7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPINK7 Gene

Proteins for SPINK7 Gene

  • Protein details for SPINK7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine protease inhibitor Kazal-type 7
    Protein Accession:
    Secondary Accessions:
    • Q32LY0

    Protein attributes for SPINK7 Gene

    85 amino acids
    Molecular mass:
    9232 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SPINK7 Gene

neXtProt entry for SPINK7 Gene

Proteomics data for SPINK7 Gene at MOPED

Post-translational modifications for SPINK7 Gene

No Post-translational modifications

Other Protein References for SPINK7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPINK7 Gene

Domains for SPINK7 Gene

Gene Families for SPINK7 Gene

  • SPINK :Serine peptidase inhibitors, Kazal type

Protein Domains for SPINK7 Gene

Suggested Antigen Peptide Sequences for SPINK7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P58062
  • Contains 1 Kazal-like domain.
genes like me logo Genes that share domains with SPINK7: view

Function for SPINK7 Gene

Molecular function for SPINK7 Gene

UniProtKB/Swiss-Prot Function: Probable serine protease inhibitor

Gene Ontology (GO) - Molecular Function for SPINK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0005515 protein binding IPI 12646258
genes like me logo Genes that share ontologies with SPINK7: view

Phenotypes for SPINK7 Gene

GenomeRNAi human phenotypes for SPINK7:
genes like me logo Genes that share phenotypes with SPINK7: view

miRNA for SPINK7 Gene

miRTarBase miRNAs that target SPINK7

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SPINK7 Gene

Localization for SPINK7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPINK7 Gene


Subcellular locations from

Jensen Localization Image for SPINK7 Gene COMPARTMENTS Subcellular localization image for SPINK7 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for SPINK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with SPINK7: view

Pathways for SPINK7 Gene

SuperPathways for SPINK7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPINK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with SPINK7: view

No data available for Pathways by source for SPINK7 Gene

Transcripts for SPINK7 Gene

Unigene Clusters for SPINK7 Gene

Serine peptidase inhibitor, Kazal type 7 (putative):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPINK7 Gene

No ASD Table

Relevant External Links for SPINK7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPINK7 Gene

mRNA expression in normal human tissues for SPINK7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPINK7 Gene

This gene is overexpressed in Esophagus - Mucosa (22.2), Vagina (19.0), and Cervix - Ectocervix (9.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SPINK7 Gene

SOURCE GeneReport for Unigene cluster for SPINK7 Gene Hs.244569

genes like me logo Genes that share expressions with SPINK7: view

No data available for mRNA Expression by UniProt/SwissProt for SPINK7 Gene

Orthologs for SPINK7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPINK7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPINK7 35
  • 98.82 (n)
  • 100 (a)
  • 100 (a)
(Bos Taurus)
Mammalia SPINK7 35
  • 85.88 (n)
  • 81.18 (a)
  • 81 (a)
(Canis familiaris)
Mammalia SPINK7 35
  • 86.67 (n)
  • 83.53 (a)
  • 64 (a)
(Mus musculus)
Mammalia Spink7 35
  • 76.08 (n)
  • 67.06 (a)
Spink7 16
Spink7 36
  • 67 (a)
(Monodelphis domestica)
Mammalia SPINK7 36
  • 52 (a)
(Rattus norvegicus)
Mammalia Spink7 35
  • 76.08 (n)
  • 68.24 (a)
Species with no ortholog for SPINK7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPINK7 Gene

Gene Tree for SPINK7 (if available)
Gene Tree for SPINK7 (if available)

Paralogs for SPINK7 Gene

Selected SIMAP similar genes for SPINK7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SPINK7: view

No data available for Paralogs for SPINK7 Gene

Variants for SPINK7 Gene

Structural Variations from Database of Genomic Variants (DGV) for SPINK7 Gene

Variant ID Type Subtype PubMed ID
nsv883015 CNV Loss 21882294
nsv5058 CNV Insertion 18451855

Relevant External Links for SPINK7 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for SPINK7 Gene

Disorders for SPINK7 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SPINK7 Gene including...

Search for SPINK7 Gene in MalaCards »

(3) Novoseek inferred disease relationships for SPINK7 Gene

Disease -log(P) Hits PubMed IDs
esophageal carcinoma 65.2 3
tumors 3.56 2
cancer 0.79 1

Relevant External Links for SPINK7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SPINK7: view

No data available for UniProtKB/Swiss-Prot for SPINK7 Gene

Publications for SPINK7 Gene

  1. ECRG2, a novel candidate of tumor suppressor gene in the esophageal carcinoma, interacts directly with metallothionein 2A and links to apoptosis. (PMID: 12646258) Cui Y. … Lu S.H. (Biochem. Biophys. Res. Commun. 2003) 2 3 23
  2. Using yeast two-hybrid system to identify ECRG2 associated proteins and their possible interactions with ECRG2 gene. (PMID: 12970870) Cui Y.P. … Lu S.H. (World J. Gastroenterol. 2003) 2 3 23
  3. Short tandem repeat polymorphisms of exon 4 in Kazal-type gene ECRG2 in pancreatic carcinoma and chronic pancreatitis. (PMID: 17352218) Kaifi J.T. … Izbicki J.R. (Anticancer Res. 2007) 3 23 48
  4. Short tandem repeat polymorphism in exon 4 of esophageal cancer-related gene 2 detected in genomic DNA is a prognostic marker for esophageal cancer. (PMID: 17693286) Kaifi J.T. … Izbicki J.R. (Am. J. Surg. 2007) 3 23 48
  5. Mapping the putative binding site for uPA protein in Esophageal Cancer-Related Gene 2 by heteronuclear NMR method. (PMID: 18824154) Geng Y. … Lu S.H. (Arch. Biochem. Biophys. 2008) 3 23

Products for SPINK7 Gene

Sources for SPINK7 Gene

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