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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPINK7 Gene

protein-coding   GIFtS: 47
GCID: GC05P147691

Serine Peptidase Inhibitor, Kazal Type 7 (Putative)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Serine Peptidase Inhibitor, Kazal Type 7 (Putative)1 2     ECRG-22 3
Esophagus Cancer Related Gene 21 2     ECRG22
Esophagus Cancer-Related Gene 2 Protein2 3     Esophagus Cancer-Related Gene-22
ECG22 3     Serine Protease Inhibitor Kazal-Type 72

External Ids:    HGNC: 246431   Entrez Gene: 846512   Ensembl: ENSG000001458797   UniProtKB: P580623   

Export aliases for SPINK7 gene to outside databases

Previous GC identifers: GC05P147673 GC05P142839


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SPINK7 Gene: 
SPINK7 (serine peptidase inhibitor, Kazal type 7 (putative)) is a protein-coding gene. Diseases associated with SPINK7 include esophageal cancer, and oral squamous cell carcinoma. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and protein binding.

UniProtKB/Swiss-Prot: ISK7_HUMAN, P58062
Function: Probable serine protease inhibitor




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_029289.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPINK7 gene promoter:
         C/EBPbeta   Sox5   oct-B3   Bach2   Pax-6   MEF-2A   POU2F1   HFH-1   aMEF-2   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPINK7 promoter sequence
   Search SABiosciences Chromatin IP Primers for SPINK7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPINK7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q32   Ensembl cytogenetic band:  5q32   HGNC cytogenetic band: 5q32

SPINK7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPINK7 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P147691:  view genomic region     (about GC identifiers)

Start:
147,691,982 bp from pter      End:
147,695,485 bp from pter
Size:
3,504 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ISK7_HUMAN, P58062 (See protein sequence)
Recommended Name: Serine protease inhibitor Kazal-type 7 precursor  
Size: 85 amino acids; 9232 Da
Subcellular location: Secreted (Potential)
1 PDB 3D structure from and Proteopedia for SPINK7:
2LEO (3D)    
Secondary accessions: Q32LY0

Explore the universe of human proteins at neXtProt for SPINK7: NX_P58062

Explore proteomics data for SPINK7 at MOPED 

SPINK7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

SPINK7 Protein Expression

REFSEQ proteins: NP_115955.1  
ENSEMBL proteins: 
 ENSP00000274565   ENSP00000427887  

Human Recombinant Protein Products for SPINK7: 
Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for SPINK7
OriGene Protein Over-expression Lysate for SPINK7
OriGene MassSpec for SPINK7 
OriGene Custom Protein Services for SPINK7
GenScript Custom Purified and Recombinant Proteins Services for SPINK7
Novus Biologicals SPINK7 Proteins
Novus Biologicals SPINK7 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

SPINK7 for ontologies           About GeneDecksing



SPINK7 Antibody Products: 
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Novus Biologicals SPINK7 Antibody
Abcam antibodies for SPINK7
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Search ThermoFisher Antibodies for SPINK7
LSBio Antibodies in human, mouse, rat for SPINK7 

Assay Products for SPINK7: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for SPINK7
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for SPINK7
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp. 
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
SPINK: Serine peptidase inhibitors, Kazal type

1 InterPro protein domain:
 IPR002350 Kazal_dom

Graphical View of Domain Structure for InterPro Entry P58062

ProtoNet protein and cluster: P58062

1 Blocks protein domain: IPB001239 Kazal-type serine protease inhibitor signature

UniProtKB/Swiss-Prot: ISK7_HUMAN, P58062
Similarity: Contains 1 Kazal-like domain


SPINK7 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: ISK7_HUMAN, P58062
Function: Probable serine protease inhibitor

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004867serine-type endopeptidase inhibitor activity IEA--
GO:0005515protein binding IPI12646258
     
SPINK7 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for SPINK7:
 Decreased POU5F1-GFP protein e 

     1 MGI phenotypic allele for Spink7 (no phenotypes)

SPINK7 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Spink7tm1Lex for SPINK7

   inGenious Targeting Laboratory - Custom generated mouse model solutions for SPINK7 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SPINK7

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPINK7 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPINK7 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPINK7
1 QIAGEN miScript miRNA Assays for microRNA that regulate SPINK7:
hsa-miR-149
SwitchGear 3'UTR luciferase reporter plasmidSPINK7 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for SPINK7
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPINK7

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for SPINK7
Sirion Biotech Customized adenovirus for overexpression of SPINK7

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for SPINK7 (see all 6)
OriGene ORF clones in mouse, rat for SPINK7
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: SPINK7 (NM_032566)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPINK7
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPINK7
Sirion Biotech Customized lentivirus for stable overexpression of SPINK7 
                     Customized lentivirus expression plasmids for stable overexpression of SPINK7 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for SPINK7
Search LifeMap BioReagents cell lines for SPINK7
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPINK7


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPINK7

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

5/15 Interacting proteins for SPINK7 (P580621, 3 ENSP000002745654) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
InteractantInteraction Details
GeneCardExternal ID(s)
EPB42P164521, 3, ENSP000003002154EBI-1182445,EBI-1182496 I2D: score=4 STRING: ENSP00000300215
MRPS12O152351, 3, ENSP000003088454EBI-1182445,EBI-712205 I2D: score=4 STRING: ENSP00000308845
MT1HP802941, 3, ENSP000003305874EBI-1182445,EBI-296567 I2D: score=4 STRING: ENSP00000330587
MT2AP027951, 3, ENSP000002451854EBI-1182445,EBI-996616 I2D: score=4 STRING: ENSP00000245185
RABL6Q3YEC71, 3, ENSP000003111344EBI-1182445,EBI-742029 I2D: score=4 STRING: ENSP00000311134
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SPINK7 (ISK7)

Search CenterWatch for drugs/clinical trials and news about SPINK7 / ISK7

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SPINK7 gene: 
NM_032566.2  

Unigene Cluster for SPINK7:

Serine peptidase inhibitor, Kazal type 7 (putative)
Hs.244569  [show with all ESTs]
Unigene Representative Sequence: AK311570
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000514394 ENST00000274565(uc003lpd.3) ENST00000514646 ENST00000504037
ENST00000523913 ENST00000523535
miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPINK7
1 QIAGEN miScript miRNA Assays for microRNA that regulate SPINK7:
hsa-miR-149
SwitchGear 3'UTR luciferase reporter plasmidSPINK7 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for SPINK7
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPINK7
Clone
Products:
     
OriGene clones in human, mouse for SPINK7 (see all 6)
OriGene ORF clones in mouse, rat for SPINK7
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: SPINK7 (NM_032566)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPINK7
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPINK7
Sirion Biotech Customized lentivirus for stable overexpression of SPINK7 
                     Customized lentivirus expression plasmids for stable overexpression of SPINK7 
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for SPINK7
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SPINK7
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPINK7
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPINK7

Additional mRNA sequence: 

AF268198.1 AK311570.1 AY359072.1 BC109385.1 BC110067.1 U47646.1 

3 DOTS entries:

DT.428158  DT.100018859  DT.92429545 

24/53 AceView cDNA sequences (see all 53):

AY359072 BE141419 BE141410 NM_032566 AW082220 BE141373 AW238399 BE141334 
AA773398 AF268198 BE350358 BE141366 BX280856 BM955686 BM955685 BM955684 
BE141361 BE141209 AW170024 AA773866 BF349223 BE141393 BE141368 BE141376 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SPINK7 expression in normal human tissues (normalized intensities)      SPINK7 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GACATAGAGA
SPINK7 Expression
About this image


SPINK7 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/5 selected tissues (see all 5) fully expand
 
 Eye (Sensory Organs)    fully expand to see all 2 entries
         AII Amacrine Cells Inner Nuclear Layer
         Human Corneal Epithelial Cells (HCEpiC)   
 
 Lung (Respiratory System)
         Human Pulmonary Microvascular Endothelial Cells (HPMEC)   
 
 Endothelium (Respiratory System)
         Human Pulmonary Microvascular Endothelial Cells (HPMEC)   
 
 Epithelium (Uncategorized)
         Human Corneal Epithelial Cells (HCEpiC)   
 
 Larynx (Respiratory System)

See SPINK7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPINK7

SOURCE GeneReport for Unigene cluster: Hs.244569
    SABiosciences Custom PCR Arrays for SPINK7
Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for SPINK7
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SPINK7
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPINK7
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPINK7
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPINK7

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for SPINK7 gene from 1/7 species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Spink71 , 5 serine peptidase inhibitor, Kazal type 7 (putative)1, 5 76.08(n)1
67.06(a)1
  18 (35.33 cM)5
4081981  NM_001001803.21  NP_001001803.21 
 625924135 


ENSEMBL Gene Tree for SPINK7 (if available)
TreeFam Gene Tree for SPINK7 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for SPINK7 gene
10 SIMAP similar genes for SPINK7 using alignment to 2 protein entries:     ISK7_HUMAN (see all proteins):
SPINK4    SPINK14    SPINK8    SPINK2    SPINK5    SPINK9
SPINK6    SLCO2A1    HEL-S-48e    SPINK13

SPINK7 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/155 SNPs in SPINK7 are shown (see all 155)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 5 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1178597821,2
C,F--147690026(+) ACCCCG/AGACGC 1 -- us2k11Minor allele frequency- A:0.04EA 120
rs591790921,2
C,F--147690030(+) CGGACC/G/TCCATG 1 -- us2k12WA EA 238
rs2002475231,2
C--147690070(+) GTGTG-/GAAGAGA 1 -- us2k10--------
rs771949951,2
C,F--147690098(+) CTAATT/GTAACA 1 -- us2k12Minor allele frequency- G:0.17WA EA 238
rs587153471,2
C,F--147690262(+) ACTAGT/ATTACA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
rs177196141,2
C,F,H--147690278(+) TCCCAA/GACAGA 1 -- us2k1 tfbs39Minor allele frequency- G:0.08NA NS EA 684
rs1391201141,2
C--147690284(+) ACAGAC/TATAGG 1 -- us2k10--------
rs1881171581,2
--147690311(+) TTATGC/TAATAT 1 -- us2k10--------
rs782744331,2
C,F--147690363(+) AGAATG/TTACTA 1 -- us2k11Minor allele frequency- T:0.07EA 120
rs1927907831,2
--147690481(+) TTGTGA/CATGGA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for SPINK7 (147691982 - 147695485 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for SPINK7:    About this table     
Variant IDTypeSubtypePubMed ID
nsv5058CNV Insertion18451855
nsv883015CNV Loss21882294


Human Gene Mutation Database (HGMD): SPINK7
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing SPINK7
DNA2.0 Custom Variant and Variant Library Synthesis for SPINK7

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
5 diseases for SPINK7:    About MalaCards
esophageal cancer    oral squamous cell carcinoma    esophagitis    squamous cell carcinoma
pancreatitis


SPINK7 for disorders           About GeneDecksing

3 Novoseek inferred disease relationships for SPINK7 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
esophageal carcinoma 65.2 3 17352218 (1), 17693286 (1), 12646258 (1)
tumors 3.56 3 12646258 (2)
cancer 0.79 1 12642876 (1)

Genetic Association Database (GAD): SPINK7
Human Genome Epidemiology (HuGE) Navigator: SPINK7 (4 documents)

Export disorders for SPINK7 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for SPINK7 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with SPINK7)
    Utopia: connect your pdf to the dynamic
world of online information

  1. ECRG2, a novel candidate of tumor suppressor gene in the esophageal carcinoma, interacts directly with metallothionein 2A and links to apoptosis. (PubMed id 12646258)1, 3, 9 Cui Y....Lu S.H. (2003)
  2. Using yeast two-hybrid system to identify ECRG2 associated proteins and their possible interactions with ECRG2 gene. (PubMed id 12970870)1, 3, 9 Cui Y.P....Lu S.H. (2003)
  3. Short tandem repeat polymorphisms of exon 4 in Kazal-type gene ECRG2 in pancreatic carcinoma and chronic pancreatitis. (PubMed id 17352218)1, 4, 9 Kaifi J.T....Izbicki J.R. (2007)
  4. Short tandem repeat polymorphism in exon 4 of esophageal cancer-related gene 2 detected in genomic DNA is a prognostic marker for esophageal cancer. (PubMed id 17693286)1, 4, 9 Kaifi J.T....Izbicki J.R. (2007)
  5. NMR structure note: human esophageal cancer-related ge ne 2. (PubMed id 22528291)1, 2 Feng Y....Wang J. (2012)
  6. Association of ECRG2 TCA short tandem repeat polymorphism with the risk of oesophageal cancer in a North Indian population. (PubMed id 18618216)1, 4 Jain M....Mittal B. (2008)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
  9. Mapping the putative binding site for uPA protein in Esophageal Cancer-Related Gene 2 by heteronuclear NMR method. (PubMed id 18824154)1, 9 Geng Y....Lu S.H. (2008)
  10. Short tandem repeat polymorphism in exon 4 of esophageal cancer related gene 2 predicts relapse of oral squamous cell carcinoma. (PubMed id 17418617)1, 9 Blessmann M....Izbicki J.R. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 84651 HGNC: 24643 AceView: ECG2 Ensembl:ENSG00000145879 euGenes: HUgn84651
ECgene: SPINK7 H-InvDB: SPINK7

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for SPINK7 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SPINK7 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for SPINK7 gene:
Search GeneIP for patents involving SPINK7

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 EMD Millipore Custom Antibody & Bulk Services
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 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SPINK7  
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 OriGene Custom Antibody Services for SPINK7   OriGene Custom Protein Services for SPINK7  

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPINK7
 QIAGEN SeqTarget long-range PCR primers for resequencing SPINK7
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPINK7
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPINK7
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 GenScript Custom Purified and Recombinant Proteins Services for SPINK7 GenScript cDNA clones with any tag delivered in your preferred vector for SPINK7
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 Regulatory tfbs in SPINK7 promoter
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 RT2 qPCR Primer Assay in human, mouse / rat SPINK7
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 Browse Sino Biological Proteins and Antibodies
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
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 See all of Abcam's Antibodies, Kits and Proteins for SPINK7
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 Browse ProSpec Recombinant Proteins




 Browse Proteins at Cloud-Clone Corp.
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 Search LifeMap BioReagents cell lines for SPINK7
 Gene Synthesis
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPINK7
 SwitchGear 3'UTR luciferase reporter plasmids for SPINK7
 SwitchGear Promoter luciferase reporter plasmids for SPINK7
 Search ThermoFisher Antibodies for SPINK7
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPINK7
 inGenious Targeting Laboratory - Custom generated mouse model solutions for SPINK7
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SPINK7
Customized:
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Customized transgenic rodents for:
 Humanization
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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