Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SPINK7 Gene

Aliases for SPINK7 Gene

  • Serine Peptidase Inhibitor, Kazal Type 7 (Putative) 2 3 5
  • Esophagus Cancer-Related Gene 2 Protein 3 4
  • ECRG-2 3 4
  • ECG2 3 4
  • Serine Protease Inhibitor Kazal-Type 7 3
  • Esophagus Cancer Related Gene 2 2
  • Esophagus Cancer-Related Gene-2 3
  • ECRG2 3

External Ids for SPINK7 Gene

Previous GeneCards Identifiers for SPINK7 Gene

  • GC05P147673
  • GC05P147691
  • GC05P142839

Summaries for SPINK7 Gene

GeneCards Summary for SPINK7 Gene

SPINK7 (Serine Peptidase Inhibitor, Kazal Type 7 (Putative)) is a Protein Coding gene. Diseases associated with SPINK7 include Esophageal Cancer. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SPINK14.

UniProtKB/Swiss-Prot for SPINK7 Gene

  • Probable serine protease inhibitor.

Additional gene information for SPINK7 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPINK7 Gene

Genomics for SPINK7 Gene

GeneHancer (GH) Regulatory Elements for SPINK7 Gene

Promoters and enhancers for SPINK7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I148312 Promoter 0.5 EPDnew 550.8 0.0 -12 0.1 SPINK7 PGBD4P3 LOC102546294
GH05I148311 Enhancer 0.2 FANTOM5 550.8 -0.9 -888 0.3 SPINK7 FBXO38 PGBD4P3 LOC102546294
GH05I148382 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 16.2 +71.8 71829 3 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 FBXO38 LOC102546294 SPINK7 ENSG00000251330 ENSG00000274799
GH05I148342 Enhancer 0.9 FANTOM5 ENCODE 31.5 +31.0 31027 1.3 NR2F1 TEAD4 TAL1 ZBED1 MAX CBFA2T3 E4F1 TCF12 JUND NCOR1 SPINK7 SPINK9 FBXO38 LOC102546294 SPINK14 ENSG00000283653
GH05I148397 Enhancer 1.2 Ensembl ENCODE dbSUPER 13.3 +85.8 85817 2.2 HDAC1 FOXA2 NEUROD1 SCRT2 FOS CEBPB GATAD2B ELF1 ZEB2 ZNF217 SPINK7 ENSG00000274799 FBXO38 PRELID3BP9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPINK7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPINK7 gene promoter:

Genomic Locations for SPINK7 Gene

Genomic Locations for SPINK7 Gene
chr5:148,312,419-148,315,922
(GRCh38/hg38)
Size:
3,504 bases
Orientation:
Plus strand
chr5:147,691,982-147,695,485
(GRCh37/hg19)

Genomic View for SPINK7 Gene

Genes around SPINK7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPINK7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPINK7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPINK7 Gene

Proteins for SPINK7 Gene

  • Protein details for SPINK7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P58062-ISK7_HUMAN
    Recommended name:
    Serine protease inhibitor Kazal-type 7
    Protein Accession:
    P58062
    Secondary Accessions:
    • Q32LY0

    Protein attributes for SPINK7 Gene

    Size:
    85 amino acids
    Molecular mass:
    9232 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SPINK7 Gene

neXtProt entry for SPINK7 Gene

Post-translational modifications for SPINK7 Gene

No Post-translational modifications

Other Protein References for SPINK7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPINK7 Gene

Domains & Families for SPINK7 Gene

Gene Families for SPINK7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for SPINK7 Gene

Suggested Antigen Peptide Sequences for SPINK7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPINK7: view

No data available for UniProtKB/Swiss-Prot for SPINK7 Gene

Function for SPINK7 Gene

Molecular function for SPINK7 Gene

UniProtKB/Swiss-Prot Function:
Probable serine protease inhibitor.

Gene Ontology (GO) - Molecular Function for SPINK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IBA --
GO:0005515 protein binding IPI 12646258
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SPINK7: view
genes like me logo Genes that share phenotypes with SPINK7: view

Animal Model Products

CRISPR Products

miRNA for SPINK7 Gene

miRTarBase miRNAs that target SPINK7

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPINK7 Gene

Localization for SPINK7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPINK7 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPINK7 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for SPINK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IBA --
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with SPINK7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SPINK7 Gene

Pathways & Interactions for SPINK7 Gene

SuperPathways for SPINK7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPINK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IEA --
GO:0060046 regulation of acrosome reaction IBA --
GO:1900004 negative regulation of serine-type endopeptidase activity IBA --
genes like me logo Genes that share ontologies with SPINK7: view

No data available for Pathways by source and SIGNOR curated interactions for SPINK7 Gene

Drugs & Compounds for SPINK7 Gene

No Compound Related Data Available

Transcripts for SPINK7 Gene

Unigene Clusters for SPINK7 Gene

Serine peptidase inhibitor, Kazal type 7 (putative):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPINK7 Gene

No ASD Table

Relevant External Links for SPINK7 Gene

GeneLoc Exon Structure for
SPINK7
ECgene alternative splicing isoforms for
SPINK7

Expression for SPINK7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPINK7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPINK7 Gene

This gene is overexpressed in Esophagus - Mucosa (x22.2), Vagina (x19.0), and Cervix - Ectocervix (x9.2).

Protein differential expression in normal tissues from HIPED for SPINK7 Gene

This gene is overexpressed in Cervix (67.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPINK7 Gene



Protein tissue co-expression partners for SPINK7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SPINK7 Gene:

SPINK7

SOURCE GeneReport for Unigene cluster for SPINK7 Gene:

Hs.244569
genes like me logo Genes that share expression patterns with SPINK7: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPINK7 Gene

Orthologs for SPINK7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPINK7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPINK7 33 34
  • 98.82 (n)
dog
(Canis familiaris)
Mammalia SPINK7 33 34
  • 86.67 (n)
cow
(Bos Taurus)
Mammalia SPINK7 33 34
  • 85.88 (n)
mouse
(Mus musculus)
Mammalia Spink7 33 16 34
  • 76.08 (n)
rat
(Rattus norvegicus)
Mammalia Spink7 33
  • 76.08 (n)
oppossum
(Monodelphis domestica)
Mammalia SPINK7 34
  • 52 (a)
OneToOne
Species where no ortholog for SPINK7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPINK7 Gene

ENSEMBL:
Gene Tree for SPINK7 (if available)
TreeFam:
Gene Tree for SPINK7 (if available)

Paralogs for SPINK7 Gene

Paralogs for SPINK7 Gene

(10) SIMAP similar genes for SPINK7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SPINK7: view

Variants for SPINK7 Gene

Sequence variations from dbSNP and Humsavar for SPINK7 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000117636 -- 148,315,387(+) G/A intron_variant
rs1001420805 -- 148,313,509(+) C/T intron_variant
rs1001687909 -- 148,312,967(+) G/A intron_variant
rs1001893583 -- 148,313,307(+) TT/ intron_variant
rs1002044665 -- 148,311,241(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SPINK7 Gene

Variant ID Type Subtype PubMed ID
esv3607102 CNV loss 21293372
esv3607106 CNV loss 21293372
esv3607107 CNV gain 21293372
nsv5058 CNV insertion 18451855
nsv599945 CNV loss 21841781

Variation tolerance for SPINK7 Gene

Residual Variation Intolerance Score: 75.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPINK7 Gene

Human Gene Mutation Database (HGMD)
SPINK7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPINK7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPINK7 Gene

Disorders for SPINK7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SPINK7 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
esophageal cancer
  • esophageal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SPINK7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SPINK7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPINK7 Gene

Publications for SPINK7 Gene

  1. Short tandem repeat polymorphism in exon 4 of esophageal cancer-related gene 2 detected in genomic DNA is a prognostic marker for esophageal cancer. (PMID: 17693286) Kaifi JT … Izbicki JR (American journal of surgery 2007) 3 22 44 58
  2. Short tandem repeat polymorphisms of exon 4 in Kazal-type gene ECRG2 in pancreatic carcinoma and chronic pancreatitis. (PMID: 17352218) Kaifi JT … Izbicki JR (Anticancer research 2007) 3 22 44 58
  3. Using yeast two-hybrid system to identify ECRG2 associated proteins and their possible interactions with ECRG2 gene. (PMID: 12970870) Cui YP … Lu SH (World journal of gastroenterology 2003) 2 3 22 58
  4. ECRG2, a novel candidate of tumor suppressor gene in the esophageal carcinoma, interacts directly with metallothionein 2A and links to apoptosis. (PMID: 12646258) Cui Y … Lu SH (Biochemical and biophysical research communications 2003) 2 3 22 58
  5. NMR structure note: human esophageal cancer-related gene 2. (PMID: 22528291) Feng Y … Wang J (Journal of biomolecular NMR 2012) 3 4 58

Products for SPINK7 Gene

Sources for SPINK7 Gene

Content
Loading form....