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Aliases for SPINK7 Gene

Aliases for SPINK7 Gene

  • Serine Peptidase Inhibitor, Kazal Type 7 (Putative) 2 3 5
  • Esophagus Cancer-Related Gene 2 Protein 3 4
  • Esophagus Cancer Related Gene 2 2 3
  • ECRG-2 3 4
  • ECG2 3 4
  • Esophagus Cancer-Related Gene-2 3
  • ECRG2 3

External Ids for SPINK7 Gene

Previous GeneCards Identifiers for SPINK7 Gene

  • GC05P147673
  • GC05P147691
  • GC05P142839

Summaries for SPINK7 Gene

GeneCards Summary for SPINK7 Gene

SPINK7 (Serine Peptidase Inhibitor, Kazal Type 7 (Putative)) is a Protein Coding gene. Diseases associated with SPINK7 include esophageal cancer. GO annotations related to this gene include serine-type endopeptidase inhibitor activity.

UniProtKB/Swiss-Prot for SPINK7 Gene

  • Probable serine protease inhibitor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPINK7 Gene

Genomics for SPINK7 Gene

Regulatory Elements for SPINK7 Gene

Genomic Location for SPINK7 Gene

Chromosome:
5
Start:
148,312,419 bp from pter
End:
148,315,922 bp from pter
Size:
3,504 bases
Orientation:
Plus strand

Genomic View for SPINK7 Gene

Genes around SPINK7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPINK7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPINK7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPINK7 Gene

Proteins for SPINK7 Gene

  • Protein details for SPINK7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P58062-ISK7_HUMAN
    Recommended name:
    Serine protease inhibitor Kazal-type 7
    Protein Accession:
    P58062
    Secondary Accessions:
    • Q32LY0

    Protein attributes for SPINK7 Gene

    Size:
    85 amino acids
    Molecular mass:
    9232 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SPINK7 Gene

neXtProt entry for SPINK7 Gene

Proteomics data for SPINK7 Gene at MOPED

Post-translational modifications for SPINK7 Gene

No Post-translational modifications

Other Protein References for SPINK7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SPINK7

No data available for DME Specific Peptides for SPINK7 Gene

Domains & Families for SPINK7 Gene

Gene Families for SPINK7 Gene

Protein Domains for SPINK7 Gene

Suggested Antigen Peptide Sequences for SPINK7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P58062

UniProtKB/Swiss-Prot:

ISK7_HUMAN :
  • Contains 1 Kazal-like domain.
Domain:
  • Contains 1 Kazal-like domain.
genes like me logo Genes that share domains with SPINK7: view

Function for SPINK7 Gene

Molecular function for SPINK7 Gene

UniProtKB/Swiss-Prot Function:
Probable serine protease inhibitor.
genes like me logo Genes that share phenotypes with SPINK7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SPINK7

miRNA for SPINK7 Gene

miRTarBase miRNAs that target SPINK7

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPINK7 Gene

Localization for SPINK7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPINK7 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPINK7 Gene COMPARTMENTS Subcellular localization image for SPINK7 gene
Compartment Confidence
extracellular 5

No data available for Gene Ontology (GO) - Cellular Components for SPINK7 Gene

Pathways & Interactions for SPINK7 Gene

SuperPathways for SPINK7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPINK7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SPINK7 Gene

Drugs & Compounds for SPINK7 Gene

No Compound Related Data Available

Transcripts for SPINK7 Gene

Unigene Clusters for SPINK7 Gene

Serine peptidase inhibitor, Kazal type 7 (putative):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPINK7 Gene

No ASD Table

Relevant External Links for SPINK7 Gene

GeneLoc Exon Structure for
SPINK7
ECgene alternative splicing isoforms for
SPINK7

Expression for SPINK7 Gene

mRNA expression in normal human tissues for SPINK7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPINK7 Gene

This gene is overexpressed in Esophagus - Mucosa (x22.2), Vagina (x19.0), and Cervix - Ectocervix (x9.2).

Protein differential expression in normal tissues from HIPED for SPINK7 Gene

This gene is overexpressed in Cervix (67.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPINK7 Gene



SOURCE GeneReport for Unigene cluster for SPINK7 Gene Hs.244569

genes like me logo Genes that share expression patterns with SPINK7: view

Protein tissue co-expression partners for SPINK7 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SPINK7 Gene

Orthologs for SPINK7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPINK7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SPINK7 35
  • 85.88 (n)
  • 81.18 (a)
SPINK7 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPINK7 35
  • 86.67 (n)
  • 83.53 (a)
SPINK7 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spink7 35
  • 76.08 (n)
  • 67.06 (a)
Spink7 16
Spink7 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SPINK7 35
  • 98.82 (n)
  • 100 (a)
SPINK7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spink7 35
  • 76.08 (n)
  • 68.24 (a)
oppossum
(Monodelphis domestica)
Mammalia SPINK7 36
  • 52 (a)
OneToOne
Species with no ortholog for SPINK7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPINK7 Gene

ENSEMBL:
Gene Tree for SPINK7 (if available)
TreeFam:
Gene Tree for SPINK7 (if available)

Paralogs for SPINK7 Gene

(10) SIMAP similar genes for SPINK7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SPINK7: view

No data available for Paralogs for SPINK7 Gene

Variants for SPINK7 Gene

Structural Variations from Database of Genomic Variants (DGV) for SPINK7 Gene

Variant ID Type Subtype PubMed ID
nsv883015 CNV Loss 21882294
nsv5058 CNV Insertion 18451855

Variation tolerance for SPINK7 Gene

Residual Variation Intolerance Score: 75.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPINK7 Gene

HapMap Linkage Disequilibrium report
SPINK7
Human Gene Mutation Database (HGMD)
SPINK7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for SPINK7 Gene

Disorders for SPINK7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SPINK7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
esophageal cancer
  • esophageal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SPINK7

Genetic Association Database (GAD)
SPINK7
Human Genome Epidemiology (HuGE) Navigator
SPINK7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPINK7
genes like me logo Genes that share disorders with SPINK7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPINK7 Gene

Publications for SPINK7 Gene

  1. ECRG2, a novel candidate of tumor suppressor gene in the esophageal carcinoma, interacts directly with metallothionein 2A and links to apoptosis. (PMID: 12646258) Cui Y. … Lu S.H. (Biochem. Biophys. Res. Commun. 2003) 2 3 23 67
  2. Using yeast two-hybrid system to identify ECRG2 associated proteins and their possible interactions with ECRG2 gene. (PMID: 12970870) Cui Y.P. … Lu S.H. (World J. Gastroenterol. 2003) 2 3 23
  3. Short tandem repeat polymorphism in exon 4 of esophageal cancer related gene 2 predicts relapse of oral squamous cell carcinoma. (PMID: 17418617) Blessmann M. … Izbicki J.R. (Oral Oncol. 2008) 3 23
  4. Mapping the putative binding site for uPA protein in Esophageal Cancer-Related Gene 2 by heteronuclear NMR method. (PMID: 18824154) Geng Y. … Lu S.H. (Arch. Biochem. Biophys. 2008) 3 23
  5. Short tandem repeat polymorphisms of exon 4 in Kazal-type gene ECRG2 in pancreatic carcinoma and chronic pancreatitis. (PMID: 17352218) Kaifi J.T. … Izbicki J.R. (Anticancer Res. 2007) 3 23

Products for SPINK7 Gene

Sources for SPINK7 Gene

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