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Aliases for SPINK6 Gene

Aliases for SPINK6 Gene

  • Serine Peptidase Inhibitor, Kazal Type 6 2 3
  • Kallikrein Inhibitor 3 4
  • Protease Inhibitor H 2 3
  • Serine Protease Inhibitor, Kazal Type 6 2
  • Serine Protease Inhibitor Kazal-Type 6 3
  • Acrosin Inhibitor 3
  • UNQ844 3
  • BUSI2 3

External Ids for SPINK6 Gene

Summaries for SPINK6 Gene

Entrez Gene Summary for SPINK6 Gene

  • The protein encoded by this gene is a Kazal-type serine protease inhibitor that acts on kallikrein-related peptidases in the skin. Two transcript variants the same protein have been found for this gene. [provided by RefSeq, Aug 2010]

GeneCards Summary for SPINK6 Gene

SPINK6 (Serine Peptidase Inhibitor, Kazal Type 6) is a Protein Coding gene. Diseases associated with SPINK6 include dyshidrosis. GO annotations related to this gene include serine-type endopeptidase inhibitor activity.

UniProtKB/Swiss-Prot for SPINK6 Gene

  • Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesnt inhibit KLK8.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPINK6 Gene

Genomics for SPINK6 Gene

Genomic Location for SPINK6 Gene

Start:
148,202,794 bp from pter
End:
148,215,137 bp from pter
Size:
12,344 bases
Orientation:
Plus strand

Genomic View for SPINK6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPINK6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPINK6 Gene

Regulatory Elements for SPINK6 Gene

Proteins for SPINK6 Gene

  • Protein details for SPINK6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWN8-ISK6_HUMAN
    Recommended name:
    Serine protease inhibitor Kazal-type 6
    Protein Accession:
    Q6UWN8
    Secondary Accessions:
    • E0X656
    • Q8N5P0

    Protein attributes for SPINK6 Gene

    Size:
    80 amino acids
    Molecular mass:
    8585 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPINK6 Gene

Proteomics data for SPINK6 Gene at MOPED

Post-translational modifications for SPINK6 Gene

No Post-translational modifications

Other Protein References for SPINK6 Gene

No data available for DME Specific Peptides for SPINK6 Gene

Domains for SPINK6 Gene

Gene Families for SPINK6 Gene

HGNC:
  • SPINK :Serine peptidase inhibitors, Kazal type

Protein Domains for SPINK6 Gene

UniProtKB/Swiss-Prot:

ISK6_HUMAN
Domain:
  • Contains 1 Kazal-like domain.:
    • Q6UWN8
genes like me logo Genes that share domains with SPINK6: view

Function for SPINK6 Gene

Molecular function for SPINK6 Gene

UniProtKB/Swiss-Prot Function: Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesnt inhibit KLK8.

Gene Ontology (GO) - Molecular Function for SPINK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SPINK6: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SPINK6 Gene

Localization for SPINK6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPINK6 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPINK6 Gene COMPARTMENTS Subcellular localization image for SPINK6 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for SPINK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with SPINK6: view

Pathways for SPINK6 Gene

SuperPathways for SPINK6 Gene

No Data Available

Interacting Proteins for SPINK6 Gene

Gene Ontology (GO) - Biological Process for SPINK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with SPINK6: view

No data available for Pathways by source for SPINK6 Gene

Compounds for SPINK6 Gene

(1) Drugbank Compounds for SPINK6 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Leucine - Reduced Carbonyl
target
genes like me logo Genes that share compounds with SPINK6: view

Transcripts for SPINK6 Gene

mRNA/cDNA for SPINK6 Gene

Unigene Clusters for SPINK6 Gene

Serine peptidase inhibitor, Kazal type 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPINK6 Gene

No ASD Table

Relevant External Links for SPINK6 Gene

GeneLoc Exon Structure for
SPINK6
ECgene alternative splicing isoforms for
SPINK6

Expression for SPINK6 Gene

mRNA expression in normal human tissues for SPINK6 Gene

mRNA differential expression in normal tissues according to GTEx for SPINK6 Gene

This gene is overexpressed in Brain - Cerebellum (10.9), Colon - Sigmoid (8.0), Vagina (7.8), Cervix - Ectocervix (7.6), Minor Salivary Gland (5.6), and Brain - Cerebellar Hemisphere (4.2).

SOURCE GeneReport for Unigene cluster for SPINK6 Gene Hs.334274

genes like me logo Genes that share expressions with SPINK6: view

Orthologs for SPINK6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPINK6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPINK6 36
  • 99.17 (n)
  • 98.75 (a)
SPINK6 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPINK6 37
  • 60 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPINK6 37
  • 60 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spink6 16
Spink6 37
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPINK6 37
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPINK6 37
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPINK6 37
  • 39 (a)
OneToOne
Species with no ortholog for SPINK6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPINK6 Gene

ENSEMBL:
Gene Tree for SPINK6 (if available)
TreeFam:
Gene Tree for SPINK6 (if available)

Paralogs for SPINK6 Gene

Selected SIMAP similar genes for SPINK6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SPINK6: view

No data available for Paralogs for SPINK6 Gene

Variants for SPINK6 Gene

Sequence variations from dbSNP and Humsavar for SPINK6 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1368306 -- 148,202,006(+) GCATC(A/G)CACTC upstream-variant-2KB
rs1432692 -- 148,205,968(+) TTCCT(A/C)ATGTT intron-variant
rs1897533 -- 148,202,323(+) GAACC(C/T)GGGAG upstream-variant-2KB
rs5872067 -- 148,202,422(+) AAAAA(-/A)GAAAA upstream-variant-2KB
rs6865474 -- 148,203,839(+) TTTTA(A/T)GACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPINK6 Gene

Variant ID Type Subtype PubMed ID
nsv883015 CNV Loss 21882294
nsv830515 CNV Gain+Loss 17160897
esv1643002 CNV Insertion 17803354
esv2730896 CNV Deletion 23290073

Relevant External Links for SPINK6 Gene

HapMap Linkage Disequilibrium report
SPINK6

Disorders for SPINK6 Gene

(1) MalaCards Diseases for SPINK6 Gene

Search for SPINK6 Gene in MalaCards »

(2) University of Copenhagen DISEASES for SPINK6 Gene

genes like me logo Genes that share disorders with SPINK6: view

No data available for UniProtKB/Swiss-Prot for SPINK6 Gene

Publications for SPINK6 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. A genomic analysis of rat proteases and protease inhibitors. (PMID: 15060002) Puente X.S. … Lopez-Otin C. (Genome Res. 2004) 2 3
  3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Isolation of SPINK6 in human skin: selective inhibitor of kallikrein- related peptidases. (PMID: 20667819) Meyer-Hoffert U. … Schroder J.M. (J. Biol. Chem. 2010) 3 4

Products for SPINK6 Gene

Sources for SPINK6 Gene

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