SPINK6 Gene
protein-coding GIFtS: 41
GCID: GC05P147564
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serine peptidase inhibitor, Kazal type 6(Previous names: serine protease inhibitor, Kazal type 6 )
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Aliases
for SPINK6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Serine Peptidase Inhibitor, Kazal Type 61 2 | | Serine Protease Inhibitor, Kazal Type 61 | | BUSI21 2 | | Acrosin Inhibitor2 | | UNQ8441 2 | | Protease Inhibitor H2 | | Kallikrein Inhibitor2 3 | | Serine Protease Inhibitor Kazal-Type 62 | | MGC213941 | | |
Export aliases for SPINK6 gene to outside databasesPrevious GC identifer: GC05P142729 |
Summaries
for SPINK6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SPINK6:
The protein encoded by this gene is a Kazal-type serine protease inhibitor that acts on kallikrein-related peptidasesin the skin. Two transcript variants the same protein have been found for this gene. (provided by RefSeq, Aug 2010)
UniProtKB/Swiss-Prot: ISK6_HUMAN, Q6UWN8Function: Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12,KLK13 and KLK14. Doesn't inhibit KLK8
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Genomic Views
for SPINK6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_029289.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPINK6 gene promoter:
c-Fos Sox5 AP-1 AML1a JunB Fra-1 FosB JunD IRF-7A c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPINK6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPINK6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q32 Ensembl cytogenetic band: 5q32 HGNC cytogenetic band: 5q32SPINK6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P147564: view genomic region
(about GC identifiers)
Start:
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147,582,357 bp from pter |
End:
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147,594,700 bp from pter |
Size:
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12,344 bases |
Orientation:
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plus strand |
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Proteins
for SPINK6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ISK6_HUMAN, Q6UWN8 (See
protein sequence)Recommended Name: Serine protease inhibitor Kazal-type 6 precursor Size: 80 amino acids; 8585 Da
Subcellular location: Secreted (Potential)
Secondary accessions: E0X656 Q8N5P0Explore the universe of human proteins at neXtProt for SPINK6: NX_Q6UWN8
SPINK6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001182219.1 NP_995313.2
ENSEMBL proteins: ENSP00000421119 ENSP00000324870
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
SPINK6 for ontologies About GeneDecksing
SPINK6 Antibody Products:
Assay Products for SPINK6: |
Protein
Domains /
Families
for SPINK6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SPINK6 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6UWN8ProtoNet protein and cluster: Q6UWN8 1 Blocks protein family: IPB001239 Kazal-type serine protease inhibitor signature
UniProtKB/Swiss-Prot: ISK6_HUMAN, Q6UWN8Similarity: Contains 1 Kazal-like domain |
Function
for SPINK6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ISK6_HUMAN, Q6UWN8Function: Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12,KLK13 and KLK14. Doesn't inhibit KLK8
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPINK6 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for SPINK6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPINK6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPINK6 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004867 | serine-type endopeptidase inhibitor activity |
IEA | -- |
SPINK6 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Spink6tm1Lex for SPINK6
1 MGI phenotypic allele  for Spink6 (no phenotypes)
SPINK6 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SPINK6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPINK6
|
Drugs & Compounds
for SPINK6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPINK6
1 DrugBank Compound for SPINK6 About this table
Search CenterWatch for drugs/clinical trials and news about SPINK6 / ISK6
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Transcripts
for SPINK6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPINK6 gene (2 alternative transcripts): NM_001195290.1 NM_205841.3 Unigene Cluster for SPINK6: Serine peptidase inhibitor, Kazal type 6 Hs.334274 [show with all ESTs]Unigene Representative Sequence: GQ5047042 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000514389 ENST00000325630(uc021yff.1 uc003lpa.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPINK6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPINK6 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): SPINK6 (NM_001195290) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPINK6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPINK6 |
Additional cDNA sequence: AY358716.1 BC032003.1 GQ504704.1 GQ504705.1 3 DOTS entries: DT.40269264 DT.120828789 DT.91736837 24/54 AceView cDNA sequences (see all 54): CB127623 BG437040 BG194136 AY358716 AI935239 BG682226 CB127187 BC032003 BG191133 BE122852 CB151643 BG182624 BG207491 CB151338 NM_205841 BG208042 BX110104 BG190022 BU565432 BG207003 BG206479 BG220067 BG198672 BG186306
GeneLoc Exon Structure
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Expression
for SPINK6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPINK6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTCTGCTCC
About this image
See SPINK6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPINK6
SOURCE GeneReport for Unigene cluster: Hs.334274
SABiosciences Custom PCR Arrays for SPINK6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPINK6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SPINK6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPINK6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPINK6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPINK6 |
Orthologs
for SPINK6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for SPINK6 gene from 1/5 species (see all 5) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SPINK66 |
Uncharacterized protein |
58(a) |
1 → many |
13(10658100-10659975) |
ENSEMBL Gene Tree for SPINK6 (if available)
TreeFam Gene Tree for SPINK6 (if available) |
Paralogs
for SPINK6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SPINK6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SPINK6 (147582357 - 147594700 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SPINK6: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPINK6 |
|
Disorders
/ Diseases
for SPINK6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SPINK6 for disorders About MalaCards
SPINK6 for disorders About GeneDecksing
2 diseases from the University of Copenhagen DISEASES database for SPINK6:Dyshidrosis Epidermolysis bullosa simplex Export disorders for SPINK6 gene to outside databases
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Publications
for SPINK6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPINK6 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with SPINK6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Inhibition of kallikrein-related peptidases by the se rine protease inhibitor of Kazal-type 6. (PubMed id 21439340)1, 2 Kantyka T....Meyer-Hoffert U. (2011)
- Isolation of Spink6 in human skin: a selective inhibitor of kallikrein-related peptidases. (PubMed id 20667819)1, 2 Meyer-Hoffert U.... Schroeder J.M. (2010)
- A genomic analysis of rat proteases and protease inhibitors. (PubMed id 15060002)1, 3 Puente X.S. and Lopez-Otin C. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)7 Imming P....Meyer A. (2006)
- How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for SPINK6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SPINK6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SPINK6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPINK6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SPINK6 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SPINK6 gene:
Search GeneIP for patents involving SPINK6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPINK6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPINK6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPINK6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPINK6 | | | OriGene Protein Over-expression Lysate for SPINK6 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPINK6 | | OriGene 3'-UTR Clone for SPINK6 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPINK6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPINK6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPINK6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPINK6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPINK6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPINK6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPINK6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPINK6 |
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| | | | Search Tocris compounds for SPINK6 |
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 | | | SPINK6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPINK6 |
|  |  |  | | | | ThermoFisher Antibodies for SPINK6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPINK6 |
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