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SPINK6 Gene

protein-coding   GIFtS: 45
GCID: GC05P147564

Serine Peptidase Inhibitor, Kazal Type 6

(Previous names: serine protease inhibitor, Kazal type 6)
  See SPINK6-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serine Peptidase Inhibitor, Kazal Type 61 2     BUSI22
Protease Inhibitor H1 2     UNQ8442
Kallikrein Inhibitor2 3     Acrosin Inhibitor2
Serine Protease Inhibitor, Kazal Type 61     Serine Protease Inhibitor Kazal-Type 62

External Ids:    HGNC: 294861   Entrez Gene: 4042032   Ensembl: ENSG000001781727   UniProtKB: Q6UWN83   

Export aliases for SPINK6 gene to outside databases

Previous GC identifer: GC05P142729


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SPINK6 Gene:
The protein encoded by this gene is a Kazal-type serine protease inhibitor that acts on kallikrein-related
peptidases in the skin. Two transcript variants the same protein have been found for this gene. (provided by
RefSeq, Aug 2010)

GeneCards Summary for SPINK6 Gene:
SPINK6 (serine peptidase inhibitor, Kazal type 6) is a protein-coding gene. Diseases associated with SPINK6 include dyshidrosis. GO annotations related to this gene include serine-type endopeptidase inhibitor activity.

UniProtKB/Swiss-Prot: ISK6_HUMAN, Q6UWN8
Function: Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12,
KLK13 and KLK14. Doesn't inhibit KLK8




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_029289.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPINK6 gene promoter:
         c-Fos   Sox5   AP-1   AML1a   JunB   Fra-1   FosB   JunD   IRF-7A   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPINK6 promoter sequence
   Search Chromatin IP Primers for SPINK6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPINK6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q32   Ensembl cytogenetic band:  5q32   HGNC cytogenetic band: 5q32

SPINK6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPINK6 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P147564:  view genomic region     (about GC identifiers)

Start:
147,582,357 bp from pter      End:
147,594,700 bp from pter
Size:
12,344 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ISK6_HUMAN, Q6UWN8 (See protein sequence)
Recommended Name: Serine protease inhibitor Kazal-type 6 precursor  
Size: 80 amino acids; 8585 Da
Secondary accessions: E0X656 Q8N5P0

Explore the universe of human proteins at neXtProt for SPINK6: NX_Q6UWN8

Explore proteomics data for SPINK6 at MOPED


See SPINK6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001182219.1  NP_995313.2  

ENSEMBL proteins: 
 ENSP00000421119   ENSP00000324870  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
SPINK: Serine peptidase inhibitors, Kazal type

1 InterPro protein domain:
 IPR002350 Kazal_dom

Graphical View of Domain Structure for InterPro Entry Q6UWN8

ProtoNet protein and cluster: Q6UWN8

1 Blocks protein domain: IPB001239 Kazal-type serine protease inhibitor signature

UniProtKB/Swiss-Prot: ISK6_HUMAN, Q6UWN8
Similarity: Contains 1 Kazal-like domain


Find genes that share domains with SPINK6           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ISK6_HUMAN, Q6UWN8
Function: Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12,
KLK13 and KLK14. Doesn't inhibit KLK8

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004867serine-type endopeptidase inhibitor activity IEA--
GO:0005515protein binding ----
     
Find genes that share ontologies with SPINK6           About GenesLikeMe


Phenotypes:
     1 MGI phenotypic allele for Spink6 (no phenotypes)

Find genes that share phenotypes with SPINK6           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Spink6tm1Lex for SPINK6

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Inhib. RNA
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ISK6_HUMAN, Q6UWN8: Secreted (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular3

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPINK6
Interactions:

    Search GeneGlobe Interaction Network for SPINK6

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for SPINK6 (ENSP000003248704) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
CCNB1IP1ENSP000003373964STRING: ENSP00000337396
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for SPINK6 (ISK6)

1 DrugBank Compound for SPINK6    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Leucine - Reduced Carbonyl-- --target--17139284 17016423 10592235



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for SPINK6 gene (2 alternative transcripts): 
NM_001195290.1  NM_205841.3  

Unigene Cluster for SPINK6:

Serine peptidase inhibitor, Kazal type 6
Hs.334274  [show with all ESTs]
Unigene Representative Sequence: GQ504704
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000514389 ENST00000325630(uc021yff.1 uc003lpa.3)
miRNA
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hsa-miR-548n
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Inhib. RNA
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  QuantiFast Probe-based Assays in human, mouse, rat SPINK6

Additional mRNA sequence: 

AY358716.1 BC032003.1 GQ504704.1 GQ504705.1 

3 DOTS entries:

DT.40269264  DT.120828789  DT.91736837 

Selected AceView cDNA sequences (see all 54):

CB127623 BG194136 BG207491 CB151643 BG182624 NM_205841 BG208042 BX110104 
CB127187 BG191133 BG437040 BC032003 CB151338 BE122852 BG682226 AI935239 
AY358716 BU565432 BG184182 BG186306 BG212213 BG207003 BG199717 BG206479 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SPINK6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTTCTGCTCC
SPINK6 Expression
About this image

SPINK6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SPINK6 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.334274
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for SPINK6 gene from Selected species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Spink65 serine peptidase inhibitor, Kazal type 6   --   18 (23.74 cM) 44071393 
chicken
(Gallus gallus)
Aves SPINK66
serine peptidase inhibitor, Kazal type 6
39(a)
1 ↔ 1
13(9918079-9921033)


ENSEMBL Gene Tree for SPINK6 (if available)
TreeFam Gene Tree for SPINK6 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SPINK6 gene
7 SIMAP similar genes for SPINK6 using alignment to 2 protein entries:     ISK6_HUMAN (see all proteins):
SPINK5    SPINK2    SPINK1    SPINK4    SPINK9    SPINK7
FSTL1

Find genes that share paralogs with SPINK6           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SPINK6 (see all 410)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 5 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs571417241,2
C,F--147580597(+) TATTTA/GTGATA 2 -- us2k12Minor allele frequency- G:0.15WA EA 238
rs1904339891,2
--147580607(+) ATAATA/GTTTCC 2 -- us2k10--------
rs1931046861,2
--147580652(+) GTGCTG/TTCATG 2 -- us2k10--------
rs599321641,2
C,F--147580667(+) TAAGCG/ATTTTT 2 -- us2k11Minor allele frequency- A:0.26EA 120
rs100656821,2
C,F,H--147580713(+) GAAAAC/TATTCT 2 -- us2k15Minor allele frequency- T:0.02NS EA WA 538
rs123324361,2
C,F,A,H--147580730(+) GAGGAT/CAGAGT 2 -- us2k121Minor allele frequency- C:0.43NA NS EA WA CSA 2378
rs1853483431,2
--147580757(+) AATTCC/TATTAA 2 -- us2k10--------
rs100749811,2
C,F,H--147580772(+) TCACCT/CATTAA 2 -- us2k15Minor allele frequency- C:0.02NS EA WA 530
rs749820671,2
C,F--147580994(+) TGTTAT/CGTTGA 2 -- us2k12Minor allele frequency- C:0.15WA EA 238
rs123326771,2
C,F,A,H--147581039(+) TTTTGC/TCACTT 2 -- us2k122Minor allele frequency- T:0.42NA NS EA WA CSA 2264

HapMap Linkage Disequilibrium report for SPINK6 (147582357 - 147594700 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for SPINK6:    About this table    
Variant IDTypeSubtypePubMed ID
esv2730896CNV Deletion23290073
esv1643002CNV Insertion17803354
nsv883015CNV Loss21882294
nsv830515CNV Gain+Loss17160897

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease for SPINK6:    
About MalaCards
dyshidrosis

2 diseases from the University of Copenhagen DISEASES database for SPINK6:
Dyshidrosis     Epidermolysis bullosa simplex

Find genes that share disorders with SPINK6           About GenesLikeMe


Export disorders for SPINK6 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SPINK6 gene, integrated from 10 sources (see all 13):
(articles sorted by number of sources associating them with SPINK6)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Inhibition of kallikrein-related peptidases by the serine protease inhibitor of Kazal-type 6. (PubMed id 21439340)1, 2 Kantyka T....Meyer-Hoffert U. (Peptides 2011)
  2. Isolation of SPINK6 in human skin: selective inhibitor of kallikrein- related peptidases. (PubMed id 20667819)1, 2 Meyer-Hoffert U.... Schroder J.M. (J. Biol. Chem. 2010)
  3. A genomic analysis of rat proteases and protease inhibitors. (PubMed id 15060002)1, 3 Puente X.S. and Lopez-Otin C. (Genome Res. 2004)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
  6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
  7. Cross-linking of SPINK6 by transglutaminases protects from epidermal proteases. (PubMed id 23303447)1 Fischer J....Meyer-Hoffert U. (J. Invest. Dermatol. 2013)
  8. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
  9. Drugs, their targets and the nature and number of drug targets. (PubMed id 17016423)7 Imming P....Meyer A. (Nat Rev Drug Discov 2006)
  10. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (Nat Rev Drug Discov 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 404203 HGNC: 29486 AceView: MGC21394 Ensembl:ENSG00000178172 euGenes: HUgn404203
ECgene: SPINK6 H-InvDB: SPINK6

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for SPINK6 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SPINK6 gene:
Search GeneIP for patents involving SPINK6

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 OriGene Custom Mass Spec   OriGene clones in human, mouse for SPINK6  
 OriGene qSTAR qPCR primer pairs in human, mouse for SPINK6   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for SPINK6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for SPINK6   OriGene Custom Protein Services for SPINK6  

 
 
 Block miRNA regulation of human, mouse, rat SPINK6 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SPINK6
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPINK6 Predesigned siRNA for gene silencing in human, mouse, rat SPINK6
 QuantiFast Probe-based Assays in human, mouse, rat SPINK6 QuantiTect SYBR Green Assays in human, mouse, rat SPINK6
 Custom PCR Arrays for SPINK6 Search Chromatin IP Primers for SPINK6
 Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SPINK6  Search GeneGlobe Interaction Network for SPINK6
 Regulatory tfbs in SPINK6 promoter
 GenScript Custom Purified and Recombinant Proteins Services for SPINK6 GenScript cDNA clones with any tag delivered in your preferred vector for SPINK6
 GenScript Custom Assay Services for SPINK6 GenScript Custom overexpressing Cell Line Services for SPINK6
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for SPINK6 (ISK6)
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
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 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
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 SPINK6 proteins
 Antibodies for SPINK6
 See all of Abcam's Antibodies, Kits and Proteins for SPINK6
 Custom Antibody / Protein Production Service
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 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for SPINK6
 Antibodies for SPINK6
 ELISAs for SPINK6
 CLIAs for SPINK6



 Browse ESI BIO Cell Lines and PureStem Progenitors for SPINK6
 Gene Synthesis
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 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPINK6
 SwitchGear 3'UTR luciferase reporter plasmids for SPINK6
 SwitchGear Promoter luciferase reporter plasmids for SPINK6
 ThermoFisher Antibodies for SPINK6
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPINK6
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPINK6
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SPINK6
 LSBio Antibodies in human, mouse, rat for SPINK6
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
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 Browse compounds at ApexBio
 Search Addgene for plasmids for SPINK6
  Search eBioscience for proteins for SPINK6
  Search eBioscience for elisas for SPINK6
  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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