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Aliases for SPINK6 Gene

Aliases for SPINK6 Gene

  • Serine Peptidase Inhibitor, Kazal Type 6 2 3 5
  • Kallikrein Inhibitor 3 4
  • Protease Inhibitor H 2 3
  • Serine Protease Inhibitor, Kazal Type 6 2
  • Acrosin Inhibitor 3
  • UNQ844 3
  • BUSI2 3

External Ids for SPINK6 Gene

Previous GeneCards Identifiers for SPINK6 Gene

  • GC05P147564
  • GC05P142729

Summaries for SPINK6 Gene

Entrez Gene Summary for SPINK6 Gene

  • The protein encoded by this gene is a Kazal-type serine protease inhibitor that acts on kallikrein-related peptidases in the skin. Two transcript variants the same protein have been found for this gene. [provided by RefSeq, Aug 2010]

GeneCards Summary for SPINK6 Gene

SPINK6 (Serine Peptidase Inhibitor, Kazal Type 6) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity.

UniProtKB/Swiss-Prot for SPINK6 Gene

  • Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesnt inhibit KLK8.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPINK6 Gene

Genomics for SPINK6 Gene

Regulatory Elements for SPINK6 Gene

Genomic Location for SPINK6 Gene

Chromosome:
5
Start:
148,202,794 bp from pter
End:
148,215,137 bp from pter
Size:
12,344 bases
Orientation:
Plus strand

Genomic View for SPINK6 Gene

Genes around SPINK6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPINK6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPINK6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPINK6 Gene

Proteins for SPINK6 Gene

  • Protein details for SPINK6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWN8-ISK6_HUMAN
    Recommended name:
    Serine protease inhibitor Kazal-type 6
    Protein Accession:
    Q6UWN8
    Secondary Accessions:
    • E0X656
    • Q8N5P0

    Protein attributes for SPINK6 Gene

    Size:
    80 amino acids
    Molecular mass:
    8585 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPINK6 Gene

Proteomics data for SPINK6 Gene at MOPED

Post-translational modifications for SPINK6 Gene

No Post-translational modifications

Other Protein References for SPINK6 Gene

Antibody Products

No data available for DME Specific Peptides for SPINK6 Gene

Domains & Families for SPINK6 Gene

Gene Families for SPINK6 Gene

Protein Domains for SPINK6 Gene

Suggested Antigen Peptide Sequences for SPINK6 Gene

Graphical View of Domain Structure for InterPro Entry

Q6UWN8

UniProtKB/Swiss-Prot:

ISK6_HUMAN :
  • Contains 1 Kazal-like domain.
Domain:
  • Contains 1 Kazal-like domain.
genes like me logo Genes that share domains with SPINK6: view

Function for SPINK6 Gene

Molecular function for SPINK6 Gene

UniProtKB/Swiss-Prot Function:
Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesnt inhibit KLK8.
genes like me logo Genes that share phenotypes with SPINK6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SPINK6

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPINK6 Gene

Localization for SPINK6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPINK6 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPINK6 Gene COMPARTMENTS Subcellular localization image for SPINK6 gene
Compartment Confidence
extracellular 5

No data available for Gene Ontology (GO) - Cellular Components for SPINK6 Gene

Pathways & Interactions for SPINK6 Gene

SuperPathways for SPINK6 Gene

No Data Available

Interacting Proteins for SPINK6 Gene

Gene Ontology (GO) - Biological Process for SPINK6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SPINK6 Gene

Drugs & Compounds for SPINK6 Gene

(1) Drugs for SPINK6 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Leucine - Reduced Carbonyl Experimental Pharma Target 0
genes like me logo Genes that share compounds with SPINK6: view

Transcripts for SPINK6 Gene

mRNA/cDNA for SPINK6 Gene

Unigene Clusters for SPINK6 Gene

Serine peptidase inhibitor, Kazal type 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPINK6 Gene

No ASD Table

Relevant External Links for SPINK6 Gene

GeneLoc Exon Structure for
SPINK6
ECgene alternative splicing isoforms for
SPINK6

Expression for SPINK6 Gene

mRNA expression in normal human tissues for SPINK6 Gene

mRNA differential expression in normal tissues according to GTEx for SPINK6 Gene

This gene is overexpressed in Brain - Cerebellum (x10.9), Colon - Sigmoid (x8.0), Vagina (x7.8), Cervix - Ectocervix (x7.6), Minor Salivary Gland (x5.6), and Brain - Cerebellar Hemisphere (x4.2).

SOURCE GeneReport for Unigene cluster for SPINK6 Gene Hs.334274

genes like me logo Genes that share expression patterns with SPINK6: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SPINK6 Gene

Orthologs for SPINK6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPINK6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPINK6 35
  • 99.17 (n)
  • 98.75 (a)
SPINK6 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPINK6 36
  • 60 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPINK6 36
  • 60 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spink6 36
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPINK6 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPINK6 36
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPINK6 36
  • 39 (a)
OneToOne
Species with no ortholog for SPINK6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPINK6 Gene

ENSEMBL:
Gene Tree for SPINK6 (if available)
TreeFam:
Gene Tree for SPINK6 (if available)

Paralogs for SPINK6 Gene

(7) SIMAP similar genes for SPINK6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SPINK6: view

No data available for Paralogs for SPINK6 Gene

Variants for SPINK6 Gene

Sequence variations from dbSNP and Humsavar for SPINK6 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs12186491 - 148,213,934(+) AGGAC(A/C/G)CCAAG reference, missense
rs1432692 -- 148,205,968(+) TTCCT(A/C)ATGTT intron-variant
rs1897533 -- 148,202,323(+) GAACC(C/T)GGGAG upstream-variant-2KB
rs5872067 -- 148,202,422(+) AAAAA(-/A)GAAAA upstream-variant-2KB
rs6883447 -- 148,203,644(+) ACAAA(G/T)ACATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPINK6 Gene

Variant ID Type Subtype PubMed ID
nsv883015 CNV Loss 21882294
nsv830515 CNV Gain+Loss 17160897
esv1643002 CNV Insertion 17803354
esv2730896 CNV Deletion 23290073

Variation tolerance for SPINK6 Gene

Residual Variation Intolerance Score: 73.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.61; 13.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPINK6 Gene

HapMap Linkage Disequilibrium report
SPINK6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPINK6 Gene

Disorders for SPINK6 Gene

Relevant External Links for SPINK6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPINK6

No disorders were found for SPINK6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPINK6 Gene

Publications for SPINK6 Gene

  1. Inhibition of kallikrein-related peptidases by the serine protease inhibitor of Kazal-type 6. (PMID: 21439340) Kantyka T. … Meyer-Hoffert U. (Peptides 2011) 3 4 67
  2. A genomic analysis of rat proteases and protease inhibitors. (PMID: 15060002) Puente X.S. … Lopez-Otin C. (Genome Res. 2004) 2 3
  3. Characterization of Spink6 in mouse skin: the conserved inhibitor of kallikrein-related peptidases is reduced by barrier injury. (PMID: 24352040) Fischer J. … Meyer-Hoffert U. (J. Invest. Dermatol. 2014) 3
  4. Cross-linking of SPINK6 by transglutaminases protects from epidermal proteases. (PMID: 23303447) Fischer J. … Meyer-Hoffert U. (J. Invest. Dermatol. 2013) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for SPINK6 Gene

Sources for SPINK6 Gene

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