SPINK5 Gene
protein-coding GIFtS: 57
GCID: GC05P147423
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serine peptidase inhibitor, Kazal type 5(Previous names: serine protease inhibitor, Kazal type 5 )
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Aliases
for SPINK5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Serine Peptidase Inhibitor, Kazal Type 51 2 | | DKFZp686K191841 | | LEKTI1 2 3 5 | | FLJ215441 | | LETKI1 2 | | FLJ975361 | | NETS1 2 | | FLJ975961 | | NS1 2 | | FLJ997941 | | VAKTI1 2 | | Lymphoepithelial Kazal-Type-Related Inhibitor2 | | Serine Protease Inhibitor, Kazal Type 51 2 | | Serine Protease Inhibitor Kazal-Type 52 | | Lympho-Epithelial Kazal-Type-Related Inhibitor2 3 | | |
Export aliases for SPINK5 gene to outside databasesPrevious GC identifers: GC05P147475 GC05P148025 GC05P147472 GC05P142590 |
Summaries
for SPINK5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SPINK5:
This gene encodes a multidomain serine protease inhibitor that contains 15 potential inhibitory domains. The inhibitormay play a role in skin and hair morphogenesis and anti-inflammatory and/or antimicrobial protection of mucousepithelia. Mutations may result in Netherton syndrome, a disorder characterized by ichthyosis, defectivecornification, and atopy. Multiple transcript variants encoding different isoforms have been found for this gene.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ISK5_HUMAN, Q9NQ38Function: Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection ofmucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activityof defense-activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner.Inhibits KLK7, KLK14 CASP14, and trypsin
Gene Wiki entry for SPINK5 (LEKTI)
|
Genomic Views
for SPINK5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_029289.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPINK5 gene promoter:
Bach1 LHX3b/Lhx3b NF-kappaB HNF-1A AREB6 HEN1 HNF-1 LHX3a/Lhx3a NF-kappaB1 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPINK5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPINK5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q32 Ensembl cytogenetic band: 5q32 HGNC cytogenetic band: 5q31-q32SPINK5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P147423: view genomic region
(about GC identifiers)
Start:
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147,405,246 bp from pter |
End:
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147,516,925 bp from pter |
Size:
|
111,680 bases |
Orientation:
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plus strand |
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Proteins
for SPINK5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ISK5_HUMAN, Q9NQ38 (See
protein sequence)Recommended Name: Serine protease inhibitor Kazal-type 5 precursor Size: 1064 amino acids; 120714 Da
Subcellular location: Secreted
5 PDB 3D structures from  and Proteopedia  for SPINK5:1H0Z (3D)
1HDL (3D)
1UUC (3D)
1UVF (3D)
1UVG (3D)
Secondary accessions: A8MYE8 B7WPB7 D6REN5 O75770 Q3LX95 Q3LX96 Q3LX97 Q96PP2 Q96PP3Alternative splicing: 3 isoforms: Q9NQ38-1 Q9NQ38-2 Q9NQ38-3 Explore the universe of human proteins at neXtProt for SPINK5: NX_Q9NQ38
Post-translational modifications:
Proteolytically processed by furin in individual domains (D1, D5, D6, D8 through D11, and D9 through D15) exhibitingvarious inhibitory potentials for multiple proteases1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NQ38
SPINK5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001121170.1 NP_001121171.1 NP_006837.2
ENSEMBL proteins: ENSP00000430264 ENSP00000381472 ENSP00000352936 ENSP00000421519 ENSP00000427943 ENSP00000256084
Human Recombinant Protein Products:
Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table
SPINK5 for ontologies About GeneDecksing
SPINK5 Antibody Products:
Assay Products for SPINK5: |
Protein
Domains /
Families
for SPINK5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SPINK5 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NQ38ProtoNet protein and cluster: Q9NQ38 1 Blocks protein family: IPB011497 Protease inhibitor
UniProtKB/Swiss-Prot: ISK5_HUMAN, Q9NQ38Domain: Contains at least one active inhibitory domain for trypsin (domain 6)Similarity: Contains 15 Kazal-like domains |
Function
for SPINK5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ISK5_HUMAN, Q9NQ38Function: Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection ofmucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activityof defense-activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner.Inhibits KLK7, KLK14 CASP14, and trypsin
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPINK5 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPINK5 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for SPINK5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPINK5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPINK5 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004867 | serine-type endopeptidase inhibitor activity |
IDA | 15680911 | | GO:0030414 | peptidase inhibitor activity |
-- | -- |
SPINK5 for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for SPINK5: Spink5tm1Drh Spink5tm1Hov
5 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Spink5):
SPINK5 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SPINK5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Development_CNTF receptor signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for SPINK5
1  GeneGo (Thomson Reuters) Pathway for SPINK5
SPINK5 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SPINK5
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for SPINK5 (Q9NQ383 ENSP000003529364) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table
SPINK5 for ontologies About GeneDecksing
|
Drugs & Compounds
for SPINK5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SPINK5 for compounds About GeneDecksing
 Browse Tocris compounds for SPINK5
1 Novoseek chemical compound relationship for SPINK5 gene About this table
Search CenterWatch for drugs/clinical trials and news about SPINK5 / ISK5
|
Transcripts
for SPINK5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPINK5 gene (3 alternative transcripts): NM_001127698.1 NM_001127699.1 NM_006846.3 Unigene Cluster for SPINK5: Serine peptidase inhibitor, Kazal type 5 Hs.331555 [show with all ESTs]Unigene Representative Sequence: NM_0011276989 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000521206 ENST00000398454(uc010jgr.2 uc003low.2) ENST00000359874(uc003loy.2 uc003lox.2)
ENST00000508733 ENST00000476697(uc010jgq.1) ENST00000507988(uc010jgs.1)
ENST00000256084 ENST00000481286 ENST00000476608
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPINK5 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPINK5 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): SPINK5 (NM_001127698) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPINK5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPINK5 |
Additional cDNA sequence: AF086524.1 AJ228139.2 AK025197.1 AK299455.1 AK301660.1 AK307648.1 AK309753.1 DQ149927.1 DQ149928.1 DQ149929.1 9 DOTS entries: DT.442169 DT.97795829 DT.92436505 DT.99998624 DT.75108289 DT.86821154 DT.87008661 DT.91840988 DT.425060 24/90 AceView cDNA sequences (see all 90): W94686 AA490580 CA450611 AA954357 T47219 BG682220 T47218 BI256857 AA496982 BP352696 BQ353977 AI831398 AA564467 BM955584 NM_006846 AJ228139 AI891123 BG740292 W95192 AI002171 AA554158 BU677429 BX648792 BU171812
GeneLoc Exon Structure
|
Expression
for SPINK5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPINK5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGGAAAAAA
About this image
See SPINK5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPINK5
SOURCE GeneReport for Unigene cluster: Hs.331555
UniProtKB/Swiss-Prot: ISK5_HUMAN, Q9NQ38Tissue specificity: Highly expressed in the thymus and stratum corneum. Also found in the oral mucosa, parathyroidgland, Bartholin's glands, tonsils, and vaginal epithelium. Very low levels are detected in lung, kidney, and prostate
SABiosciences Expression via Pathway-Focused PCR Array including SPINK5: | Angiogenic Growth Factors in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPINK5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPINK5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPINK5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPINK5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPINK5 |
Orthologs
for SPINK5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SPINK5 gene from 2/8 species (see all 8) About this table
ENSEMBL Gene Tree for SPINK5 (if available)
TreeFam Gene Tree for SPINK5 (if available) |
Paralogs
for SPINK5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SPINK5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SPINK5 (147405246 - 147516925 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for SPINK5
2 CNVs: 99318 39436
5 Indels: 40806 42103 62441 46786 12765
Human Gene Mutation Database (HGMD): SPINK5
Locus Specific Mutation Databases (LSDB): SPINK5
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPINK5 |
|
Disorders
/ Diseases
for SPINK5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SPINK5 for disorders About GeneDecksing
OMIM gene information: 605010
OMIM disorders: 256500 147050
UniProtKB/Swiss-Prot: ISK5_HUMAN, Q9NQ38
Defects in SPINK5 are the cause of Netherton syndrome (NETH) [MIM:256500]. NETH is an autosomal recessivecongenital ichthyosis associated with hair shaft abnormalities and anomalies of the immune system. Typical featuresare ichthyosis linearis circumflexa, ichthyosiform erythroderma, trichorrhexis invaginata (bamboo hair), atopicdermatitis, and hayfever. High postnatal mortality is due to failure to thrive, infections and hypernatremicdehydration
20/27  diseases for SPINK5 (see all 27): About MalaCardsnetherton syndrome ichthyosis ichthyosis linearis circumflexa atopy
congenital ichthyosiform erythroderma autosomal recessive congenital ichthyosis multiple endocrine neoplasia celiac disease
atopic dermatitis psoriatic arthritis skin disease carcinoid syndrome
dermatitis rickets neuroendocrine carcinoma eczema
psoriasis tonsillitis acute pancreatitis vaginitis
3 diseases from the University of Copenhagen DISEASES database for SPINK5:Netherton syndrome Congenital ichthyosiform erythroderma Atopic dermatitis 10/11 Novoseek disease relationships for SPINK5 gene (see all 11) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| netherton syndrome |
98.7 |
49 |
17608759 (3), 11874482 (3), 16374478 (2), 17989726 (2) (see all 27) |
| ichthyosiform erythroderma congenital |
91.8 |
2 |
15606522 (2) |
| congenital ichthyosis |
81.4 |
3 |
19683336 (1) |
| ichthyosis |
76.1 |
2 |
16120162 (1), 15675955 (1) |
| dermatitis atopic |
75.8 |
23 |
15753894 (4), 17989887 (3), 12752122 (2), 19534795 (2) (see all 10) |
| atopy |
65.4 |
3 |
12752122 (2), 19534795 (1) |
| skin diseases |
63.8 |
10 |
17989726 (1), 14551605 (1), 15466487 (1), 16307658 (1) (see all 6) |
| asthma |
40.2 |
23 |
15753894 (5), 19534795 (5), 14551605 (2), 15820494 (1) (see all 7) |
| growth retardation |
34.7 |
1 |
17140555 (1) |
| psoriasis |
26.2 |
2 |
15606522 (2) |
Genetic Association Database (GAD): SPINK5
Human Genome Epidemiology (HuGE) Navigator: SPINK5 (21 documents)
Export disorders for SPINK5 gene to outside databases
|
Publications
for SPINK5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPINK5 gene, integrated from 9 sources (see all 87):
(articles sorted by number of sources associating them with SPINK5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Gene polymorphism in Netherton and common atopic disease. (PubMed id 11544479)1, 2, 4 Walley A.J.... Cookson W.O.C.M. (2001)
- LEKTI, a novel 15-domain type of human serine proteinase inhibitor. (PubMed id 10419450)1, 2, 3 Maegert H.-J.... Forssmann W.-G. (1999)
- SPINK5, the defective gene in netherton syndrome, encodes multiple LEKTI isoforms derived from alternative pre-mRNA processing. (PubMed id 16374478)1, 2, 9 Tartaglia-Polcini A.... D'Alessio M. (2006)
- Association of SPINK5 gene polymorphisms with atopic dermatitis in the Japanese population. (PubMed id 12752122)1, 4, 9 Kato A....Ishii M. (2003)
- The spectrum of pathogenic mutations in SPINK5 in 19 families with Netherton syndrome: implications for mutation detection and first case of prenatal diagnosis. (PubMed id 11511292)1, 2, 9 Sprecher E....Richard G. (2001)
- Rapid detection of the SPINK5 polymorphism Glu420Lys by real-time PCR technology. (PubMed id 15820494)1, 4, 9 Rihs H.P....Bruning T. (2005)
- Asthma severity and genetics in Taiwan. (PubMed id 15986064)1, 4, 9 Huang J.L. (2005)
- Association between polymorphisms in serine protease inhibitor, kazal type 5 and asthma phenotypes in a large German population sample. (PubMed id 15005725)1, 4, 9 Kabesch M....von Mutius E. (2004)
- Purification and partial amino acid sequence of proteins from human epidermal keratinocyte conditioned medium. (PubMed id 11594460)1, 2, 9 Ahmed A.... Parenteau N. (2001)
- New role for LEKTI in skin barrier formation: label-free quantitative proteomic identification of caspase 14 as a novel target for the protease inhibitor LEKTI. (PubMed id 20533828)1, 2 Bennett K.... Mills K. (2010)
|
External Searches for SPINK5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SPINK5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SPINK5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPINK5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SPINK5 | Pharmacogenomics, SNPs, Pathways | | SPINK5base | http://bioinf.uta.fi/SPINK5base/ | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/SPINK5 |
|
| | |
About This Section
| Patent Information for SPINK5 gene:
Search GeneIP for patents involving SPINK5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPINK5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPINK5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPINK5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPINK5 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPINK5 | | OriGene 3'-UTR Clone for SPINK5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPINK5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPINK5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SPINK5 | | OriGene Custom Protein Services for SPINK5 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPINK5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPINK5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPINK5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPINK5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPINK5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPINK5 |
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| | | | Search Tocris compounds for SPINK5 |
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 | | | SPINK5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPINK5 |
|  |  |  | | | | Search ThermoFisher Antibodies for SPINK5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPINK5 |
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