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Aliases for SPINK4 Gene

Aliases for SPINK4 Gene

  • Serine Peptidase Inhibitor, Kazal Type 4 2 3 5
  • Serine Protease Inhibitor, Kazal Type 4 2 3
  • Peptide PEC-60 Homolog 3 4
  • Epididymis Luminal Protein 136 3
  • Gastrointestinal Peptide 3
  • HEL136 3
  • PEC-60 3
  • PEC60 3

External Ids for SPINK4 Gene

Previous GeneCards Identifiers for SPINK4 Gene

  • GC09P033552
  • GC09P033409
  • GC09P033208

Summaries for SPINK4 Gene

GeneCards Summary for SPINK4 Gene

SPINK4 (Serine Peptidase Inhibitor, Kazal Type 4) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPINK4 Gene

Genomics for SPINK4 Gene

Regulatory Elements for SPINK4 Gene

Enhancers for SPINK4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SPINK4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPINK4 Gene

33,218,365 bp from pter
33,248,567 bp from pter
30,203 bases
Plus strand

Genomic View for SPINK4 Gene

Genes around SPINK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPINK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPINK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPINK4 Gene

Proteins for SPINK4 Gene

  • Protein details for SPINK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine protease inhibitor Kazal-type 4
    Protein Accession:
    Secondary Accessions:
    • Q2YDT7

    Protein attributes for SPINK4 Gene

    86 amino acids
    Molecular mass:
    9454 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPINK4 Gene

Proteomics data for SPINK4 Gene at MOPED

Post-translational modifications for SPINK4 Gene

No Post-translational modifications

Other Protein References for SPINK4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPINK4 Gene

Domains & Families for SPINK4 Gene

Gene Families for SPINK4 Gene

Protein Domains for SPINK4 Gene


Suggested Antigen Peptide Sequences for SPINK4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Kazal-like domain.
  • Contains 1 Kazal-like domain.
genes like me logo Genes that share domains with SPINK4: view

Function for SPINK4 Gene

genes like me logo Genes that share phenotypes with SPINK4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SPINK4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPINK4 Gene

Localization for SPINK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPINK4 Gene


Subcellular locations from

Jensen Localization Image for SPINK4 Gene COMPARTMENTS Subcellular localization image for SPINK4 gene
Compartment Confidence
extracellular 5
golgi apparatus 2

No data available for Gene Ontology (GO) - Cellular Components for SPINK4 Gene

Pathways & Interactions for SPINK4 Gene

SuperPathways for SPINK4 Gene

No Data Available

Interacting Proteins for SPINK4 Gene

Gene Ontology (GO) - Biological Process for SPINK4 Gene


No data available for Pathways by source and SIGNOR curated interactions for SPINK4 Gene

Drugs & Compounds for SPINK4 Gene

No Compound Related Data Available

Transcripts for SPINK4 Gene

mRNA/cDNA for SPINK4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPINK4 Gene

Serine peptidase inhibitor, Kazal type 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPINK4 Gene

No ASD Table

Relevant External Links for SPINK4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPINK4 Gene

mRNA expression in normal human tissues for SPINK4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPINK4 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x37.4) and Colon - Transverse (x13.9).

Protein differential expression in normal tissues from HIPED for SPINK4 Gene

This gene is overexpressed in Rectum (34.5), Colon (20.4), and Fetal gut (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPINK4 Gene

SOURCE GeneReport for Unigene cluster for SPINK4 Gene Hs.555934

genes like me logo Genes that share expression patterns with SPINK4: view

Protein tissue co-expression partners for SPINK4 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SPINK4 Gene

Orthologs for SPINK4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPINK4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SPINK4 35
  • 81.78 (n)
  • 69.77 (a)
  • 70 (a)
(Canis familiaris)
Mammalia SPINK4 35
  • 82.95 (n)
  • 73.26 (a)
  • 73 (a)
(Mus musculus)
Mammalia Spink4 35
  • 77.13 (n)
  • 62.79 (a)
Spink4 16
Spink4 36
  • 63 (a)
(Pan troglodytes)
Mammalia SPINK4 35
  • 99.61 (n)
  • 98.84 (a)
  • 62 (a)
(Rattus norvegicus)
Mammalia Spink4 35
  • 79.11 (n)
  • 64 (a)
(Monodelphis domestica)
Mammalia SPINK4 36
  • 55 (a)
(Gallus gallus)
Aves SPINK4 36
  • 28 (a)
(Danio rerio)
Actinopterygii SPINK4 36
  • 45 (a)
Species with no ortholog for SPINK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPINK4 Gene

Gene Tree for SPINK4 (if available)
Gene Tree for SPINK4 (if available)

Paralogs for SPINK4 Gene

(8) SIMAP similar genes for SPINK4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SPINK4: view

No data available for Paralogs for SPINK4 Gene

Variants for SPINK4 Gene

Sequence variations from dbSNP and Humsavar for SPINK4 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs706107 - 33,240,227(-) GATTA(C/T)CCACT reference, missense
rs696286 -- 33,249,061(-) TCCCC(C/T)CCCAC downstream-variant-500B
rs706105 -- 33,238,472(-) GGGAT(A/G)CCTCT upstream-variant-2KB
rs706106 -- 33,238,651(-) AAAAA(A/T)TTTTT upstream-variant-2KB
rs706108 -- 33,240,522(-) CCCTC(C/T)TTTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPINK4 Gene

Variant ID Type Subtype PubMed ID
nsv893017 CNV Gain 21882294
nsv519369 CNV Gain 19592680

Variation tolerance for SPINK4 Gene

Residual Variation Intolerance Score: 72.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.24; 5.33% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SPINK4 Gene

Disorders for SPINK4 Gene

Relevant External Links for SPINK4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SPINK4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPINK4 Gene

Publications for SPINK4 Gene

  1. The SPINK gene family and celiac disease susceptibility. (PMID: 17333166) Wapenaar M.C. … Wijmenga C. (Immunogenetics 2007) 2 3 48 67
  2. Molecular cloning of PEC-60 and expression of its mRNA and peptide in the gastrointestinal tract and immune system. (PMID: 1400298) Metsis M. … Mutt V. (J. Biol. Chem. 1992) 2 3
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  4. Gastrointestinal peptides controlling body weight homeostasis. (PMID: 18164707) Mendieta-ZerA^n H. … DiAcguez C. (Gen. Comp. Endocrinol. 2008) 23
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3

Products for SPINK4 Gene

Sources for SPINK4 Gene