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Aliases for SPINK4 Gene

Aliases for SPINK4 Gene

  • Serine Peptidase Inhibitor, Kazal Type 4 2 3
  • Serine Protease Inhibitor, Kazal Type 4 2 3
  • Peptide PEC-60 Homolog 3 4
  • PEC60 3 6
  • Serine Protease Inhibitor Kazal-Type 4 3
  • Epididymis Luminal Protein 136 3
  • Gastrointestinal Peptide 3
  • HEL136 3
  • PEC-60 3

External Ids for SPINK4 Gene

Previous GeneCards Identifiers for SPINK4 Gene

  • GC09P033552
  • GC09P033409
  • GC09P033208

Summaries for SPINK4 Gene

GeneCards Summary for SPINK4 Gene

SPINK4 (Serine Peptidase Inhibitor, Kazal Type 4) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPINK4 Gene

Genomics for SPINK4 Gene

Regulatory Elements for SPINK4 Gene

Genomic Location for SPINK4 Gene

Start:
33,218,365 bp from pter
End:
33,248,567 bp from pter
Size:
30,203 bases
Orientation:
Plus strand

Genomic View for SPINK4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPINK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPINK4 Gene

Proteins for SPINK4 Gene

  • Protein details for SPINK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60575-ISK4_HUMAN
    Recommended name:
    Serine protease inhibitor Kazal-type 4
    Protein Accession:
    O60575
    Secondary Accessions:
    • Q2YDT7

    Protein attributes for SPINK4 Gene

    Size:
    86 amino acids
    Molecular mass:
    9454 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPINK4 Gene

Proteomics data for SPINK4 Gene at MOPED

Post-translational modifications for SPINK4 Gene

No Post-translational modifications

Other Protein References for SPINK4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPINK4 Gene

Domains for SPINK4 Gene

Gene Families for SPINK4 Gene

HGNC:
  • SPINK :Serine peptidase inhibitors, Kazal type

Protein Domains for SPINK4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPINK4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60575

UniProtKB/Swiss-Prot:

ISK4_HUMAN :
  • O60575
Domain:
  • Contains 1 Kazal-like domain.
genes like me logo Genes that share domains with SPINK4: view

Function for SPINK4 Gene

Gene Ontology (GO) - Molecular Function for SPINK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SPINK4: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPINK4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SPINK4 Gene

Localization for SPINK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPINK4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPINK4 Gene COMPARTMENTS Subcellular localization image for SPINK4 gene
Compartment Confidence
extracellular 3
nucleus 1

Gene Ontology (GO) - Cellular Components for SPINK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with SPINK4: view

Pathways for SPINK4 Gene

SuperPathways for SPINK4 Gene

No Data Available

Interacting Proteins for SPINK4 Gene

Gene Ontology (GO) - Biological Process for SPINK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0042493 response to drug IEA --
genes like me logo Genes that share ontologies with SPINK4: view

No data available for Pathways by source for SPINK4 Gene

Transcripts for SPINK4 Gene

mRNA/cDNA for SPINK4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPINK4 Gene

Serine peptidase inhibitor, Kazal type 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPINK4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SPINK4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPINK4 Gene

No ASD Table

Relevant External Links for SPINK4 Gene

GeneLoc Exon Structure for
SPINK4
ECgene alternative splicing isoforms for
SPINK4

Expression for SPINK4 Gene

mRNA expression in normal human tissues for SPINK4 Gene

mRNA differential expression in normal tissues according to GTEx for SPINK4 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (37.4) and Colon - Transverse (13.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SPINK4 Gene

SOURCE GeneReport for Unigene cluster for SPINK4 Gene Hs.555934

genes like me logo Genes that share expressions with SPINK4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SPINK4 Gene

Orthologs for SPINK4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPINK4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPINK4 35
  • 99.61 (n)
  • 98.84 (a)
SPINK4 36
  • 62 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPINK4 35
  • 81.78 (n)
  • 69.77 (a)
SPINK4 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPINK4 35
  • 82.95 (n)
  • 73.26 (a)
SPINK4 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spink4 35
  • 77.13 (n)
  • 62.79 (a)
Spink4 16
Spink4 36
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPINK4 36
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spink4 35
  • 79.11 (n)
  • 64 (a)
chicken
(Gallus gallus)
Aves SPINK4 36
  • 28 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii SPINK4 36
  • 45 (a)
OneToOne
Species with no ortholog for SPINK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPINK4 Gene

ENSEMBL:
Gene Tree for SPINK4 (if available)
TreeFam:
Gene Tree for SPINK4 (if available)

Paralogs for SPINK4 Gene

Selected SIMAP similar genes for SPINK4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SPINK4: view

No data available for Paralogs for SPINK4 Gene

Variants for SPINK4 Gene

Sequence variations from dbSNP and Humsavar for SPINK4 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs474288 -- 33,239,247(-) ggctg(A/G)tctcg upstream-variant-2KB
rs480583 -- 33,245,078(-) TATGC(C/T)GGCTC intron-variant
rs507398 -- 33,241,748(-) CCAAA(A/G)TGCCC intron-variant
rs521476 -- 33,244,758(-) CCCCT(A/C)TCTTA intron-variant
rs547958 -- 33,241,003(-) cctgc(C/T)aagta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPINK4 Gene

Variant ID Type Subtype PubMed ID
nsv893017 CNV Gain 21882294
nsv519369 CNV Gain 19592680

Relevant External Links for SPINK4 Gene

HapMap Linkage Disequilibrium report
SPINK4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPINK4 Gene

Disorders for SPINK4 Gene

Relevant External Links for SPINK4

Genetic Association Database (GAD)
SPINK4
Human Genome Epidemiology (HuGE) Navigator
SPINK4
genes like me logo Genes that share disorders with SPINK4: view

No data available for UniProtKB/Swiss-Prot for SPINK4 Gene

Publications for SPINK4 Gene

  1. The SPINK gene family and celiac disease susceptibility. (PMID: 17333166) Wapenaar M.C. … Wijmenga C. (Immunogenetics 2007) 2 3 48
  2. Molecular cloning of PEC-60 and expression of its mRNA and peptide in the gastrointestinal tract and immune system. (PMID: 1400298) Metsis M. … Mutt V. (J. Biol. Chem. 1992) 2 3
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SPINK4 Gene

Sources for SPINK4 Gene

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