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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPINK2 Gene

protein-coding   GIFtS: 52
GCID: GC04M057676

Serine Peptidase Inhibitor, Kazal Type 2 (Acrosin-Trypsin...

(Previous names: serine protease inhibitor, Kazal type 2 (acrosin-trypsin...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Serine Peptidase Inhibitor, Kazal Type 2 (Acrosin-Trypsin
Inhibitor)1 2
Epididymis Tissue Protein Li 1722 3
HUSI-II2 3
Serine Protease Inhibitor, Kazal Type 2 (Acrosin-Trypsin Inhibitor)1
Serine Protease Inhibitor Kazal-Type 22
Acrosin-Trypsin Inhibitor3

External Ids:    HGNC: 112451   Entrez Gene: 66912   Ensembl: ENSG000001280407   OMIM: 6057535   UniProtKB: P201553   

Export aliases for SPINK2 gene to outside databases

Previous GC identifers: GC04M057479 GC04M057637 GC04M057591 GC04M057516 GC04M057370 GC04M053629


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SPINK2 Gene:
This gene encodes a member of the family of serine protease inhibitors of the Kazal type (SPINK). The encoded
protein acts as a trypsin and acrosin inhibitor in the genital tract and is localized in the spermatozoa. The
protein has been associated with the progression of lymphomas. Alternative splicing results in multiple
transcript variants. (provided by RefSeq, Nov 2012)

GeneCards Summary for SPINK2 Gene: 
SPINK2 (serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)) is a protein-coding gene. Diseases associated with SPINK2 include epididymitis, and celiac disease. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and endopeptidase inhibitor activity.

UniProtKB/Swiss-Prot: ISK2_HUMAN, P20155
Function: Strong inhibitor of acrosin in male and/or female genital tract. Also inhibits trypsin

Gene Wiki entry for SPINK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_022853.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPINK2 gene promoter:
         NRSF form 1   Brachyury   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPINK2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SPINK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPINK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12   Ensembl cytogenetic band:  4q12   HGNC cytogenetic band: 4q12

SPINK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPINK2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M057676:  view genomic region     (about GC identifiers)

Start:
57,676,026 bp from pter      End:
57,687,908 bp from pter
Size:
11,883 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ISK2_HUMAN, P20155 (See protein sequence)
Recommended Name: Serine protease inhibitor Kazal-type 2 precursor  
Size: 84 amino acids; 9291 Da
Subcellular location: Secreted
1 PDB 3D structure from and Proteopedia for SPINK2:
2JXD (3D)    
Secondary accessions: Q6FGH2

Explore the universe of human proteins at neXtProt for SPINK2: NX_P20155

Explore proteomics data for SPINK2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P20155

  • SPINK2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SPINK2 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001258647.1  NP_001258648.1  NP_001258649.1  NP_001258650.1  NP_001258651.1  NP_066937.1  

    ENSEMBL proteins: 
     ENSP00000248701   ENSP00000425961   ENSP00000423858  

    Human Recombinant Protein Products for SPINK2: 
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    Novus Biologicals SPINK2 Proteins
    Novus Biologicals SPINK2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SPINK2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0005576extracellular region IEA--
    GO:0044444cytoplasmic part ----

    SPINK2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SPINK: Serine peptidase inhibitors, Kazal type

    1 InterPro protein domain:
     IPR002350 Kazal_dom

    Graphical View of Domain Structure for InterPro Entry P20155

    ProtoNet protein and cluster: P20155

    1 Blocks protein domain: IPB001239 Kazal-type serine protease inhibitor signature

    UniProtKB/Swiss-Prot: ISK2_HUMAN, P20155
    Similarity: Contains 1 Kazal-like domain


    SPINK2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ISK2_HUMAN, P20155
    Function: Strong inhibitor of acrosin in male and/or female genital tract. Also inhibits trypsin

         Genatlas biochemistry entry for SPINK2:
    serine protease inhibitor,Kazal type 2 (acrosin-trypsin inhibitor)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004866endopeptidase inhibitor activity TAS8428671
    GO:0004867serine-type endopeptidase inhibitor activity IEA--
    GO:0005515protein binding ----
         
    SPINK2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SPINK2:
     Synthetic lethal with Ras  Synthetic lethal with c-Myc af 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Spink2):
     cellular  endocrine/exocrine gland  reproductive system 

    SPINK2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SPINK2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SPINK2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPINK2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPINK2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPINK2
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate SPINK2:
    hsa-miR-7-1* hsa-miR-7-2*
    SwitchGear 3'UTR luciferase reporter plasmidSPINK2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPINK2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SPINK2

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002176male germ cell proliferation IEA--
    GO:0007283spermatogenesis ----
    GO:0007286spermatid development IEA--
    GO:0008584male gonad development ----
    GO:0009566fertilization IEA--

    SPINK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPINK2 (ISK2)

    Search CenterWatch for drugs/clinical trials and news about SPINK2 / ISK2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SPINK2 gene (6 alternative transcripts): 
    NM_001271718.1  NM_001271719.1  NM_001271720.1  NM_001271721.1  NM_001271722.1  NM_021114.3  

    Unigene Cluster for SPINK2:

    Serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
    Hs.98243  [show with all ESTs]
    Unigene Representative Sequence: BM563686
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000509707 ENST00000248701(uc003hcg.1) ENST00000506738 ENST00000504762

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPINK2
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate SPINK2:
    hsa-miR-7-1* hsa-miR-7-2*
    SwitchGear 3'UTR luciferase reporter plasmidSPINK2 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPINK2
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPINK2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPINK2

    Additional mRNA sequence: 

    AK312222.1 BC022514.1 CR542135.1 GU727622.1 NR_073417.1 NR_073418.1 NR_073419.1 X57655.1 

    3 DOTS entries:

    DT.444486  DT.100780011  DT.92421817 

    24/73 AceView cDNA sequences (see all 73):

    AW950531 AA335752 AA973772 CR542135 BC022514 BM314125 AA779272 BM313844 
    AA625888 BG214688 AW182819 CK905202 BI520020 AA570635 BI561149 AA548428 
    BI827169 AW082715 BG193436 X57655 BI562269 BG700147 AJ713665 AA872176 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SPINK2    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c
    SP1:                                                      
    SP2:              -     -                                 
    SP3:                    -                                 


    ECgene alternative splicing isoforms for SPINK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPINK2 expression in normal human tissues (normalized intensities)      SPINK2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTAGTGATG
    SPINK2 Expression
    About this image


    SPINK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Testis (Reproductive System)    fully expand to see all 8 entries
             XY Germ Cells Testis Cord
             Testis Interstitium
             seminal vesicle ; glandular cells   
             sperm   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Bone Marrow CD34+ Cells   
     
     Endothelium (Cardiovascular System)
             blood vessel   
     
     Liver (Hepatobiliary System)
             Fetal Liver CD34+ Cells   
     
     Adipose (Muscoskeletal System)
             HyStem+BMP4-induced 7SMOO32 cells

    See SPINK2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPINK2

    SOURCE GeneReport for Unigene cluster: Hs.98243

    UniProtKB/Swiss-Prot: ISK2_HUMAN, P20155
    Tissue specificity: Expressed in epididymis (at protein level)

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPINK2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SPINK2 gene from 4/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spink21 , 5 serine peptidase inhibitor, Kazal type 21, 5 66.25(n)1
    58.75(a)1
      5 (41.53 cM)5
    699821  NM_183284.21  NP_899107.11 
     772051075 
    chicken
    (Gallus gallus)
    Aves SPINK26
    serine peptidase inhibitor, Kazal type 2 (acrosin-...
    45(a)
    1 ↔ 1
    4(48706786-48712370)
    lizard
    (Anolis carolinensis)
    Reptilia SPINK26
    Uncharacterized protein
    51(a)
    1 ↔ 1
    GL343257.1(1419937-1603080)
    zebrafish
    (Danio rerio)
    Actinopterygii SPINK2 (4 of 4)6
    SPINK2 (3 of 4)6
    (see all 4)
    serine peptidase inhibitor, Kazal type 2 (acrosin-...
    serine peptidase inhibitor, Kazal type 2 (acrosin-...
    (see all 4)
    41(a)
    40(a)
    (see all 4)
    many → 1
    many → 1
    (see all 4)
    14(19497074-19497787)
    14(19091267-19092139)


    ENSEMBL Gene Tree for SPINK2 (if available)
    TreeFam Gene Tree for SPINK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPINK2 gene
    7 SIMAP similar genes for SPINK2 using alignment to 3 protein entries:     ISK2_HUMAN (see all proteins):
    SPINK8    SPINK6    SPINK9    SPINK5    SPINK1    SPINK7
    SPINK4

    SPINK2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/430 SNPs in SPINK2 are shown (see all 430)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs776166471,2
    C--57675552(+) ATTTTC/TGAGAC 9 -- ds50010--------
    rs793714441,2
    C--57675561(+) ACAGAC/G/TTCTCG 9 -- ds50010--------
    rs1496439841,2
    C--57675620(+) ACCTCC/TGCCTC 9 -- ds50010--------
    rs1876132461,2
    --57675633(+) GGGTTC/TGAGCG 9 -- ds50010--------
    rs1444085081,2
    --57675634(+) GGTTCG/TAGCGA 9 -- ds50010--------
    rs1932140681,2
    --57675648(+) TCCTGC/TCTCAG 9 -- ds50010--------
    rs1483445521,2
    C--57675660(+) CTCCCA/GAGTAG 9 -- ds50010--------
    rs1850753601,2
    --57675670(+) GCTGGA/GACTAC 9 -- ds50010--------
    rs1421914521,2
    C--57675769(+) AGCTCA/GTGATA 9 -- ds50010--------
    rs1875108331,2
    --57675779(+) ACGCCC/TGCCTC 9 -- ds50010--------

    HapMap Linkage Disequilibrium report for SPINK2 (57676026 - 57687908 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SPINK2: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SPINK2
    DNA2.0 Custom Variant and Variant Library Synthesis for SPINK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605753    OMIM disorders: --

    3 diseases for SPINK2:    About MalaCards
    epididymitis    celiac disease    infertility


    SPINK2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SPINK2
    Human Genome Epidemiology (HuGE) Navigator: SPINK2 (1 document)

    Export disorders for SPINK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPINK2 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with SPINK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Organization and sequence of the gene encoding the human acrosin- trypsin inhibitor (HUSI-II). (PubMed id 8428671)1, 2, 3 Moeritz A.... Fink E. (1993)
    2. Identification of trypsin-inhibitory site and structure determination of human SPINK2 serine proteinase inhibitor. (PubMed id 19422058)1, 2, 9 Chen T.... Lyu P.-C. (2009)
    3. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PubMed id 20736409)1, 2 Li J.... Liu Y. (2010)
    4. The SPINK gene family and celiac disease susceptibility. (PubMed id 17333166)1, 4 Wapenaar M.C....Wijmenga C. (2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Molecular cloning and sequence analysis of the cDNA encoding the human acrosin-trypsin inhibitor (HUSI-II). (PubMed id 1704312)1, 2 Moeritz A.... Fink E. (1991)
    7. Amino acid sequence elucidation of human acrosin-trypsin inhibitor (HUSI-II) reveals that Kazal-type proteinase inhibitors are structurally related to beta-subunits of glycoprotein hormones. (PubMed id 2226783)1, 2 Fink E.... Eulitz M. (1990)
    8. A germline-specific class of small RNAs binds mammali an Piwi proteins. (PubMed id 16751776)1 Girard A....Carmell M.A. (2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    10. Gene expression patterns associated with infertility in humans and rodent models. (PubMed id 15120973)1 Rockett J.C....Dix D.J. (2004)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6691 HGNC: 11245 AceView: SPINK2 Ensembl:ENSG00000128040 euGenes: HUgn6691
    ECgene: SPINK2 H-InvDB: SPINK2

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for SPINK2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for SPINK2 gene:
    Search GeneIP for patents involving SPINK2

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