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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SPINK2 Gene

protein-coding GIFtS: 49
GCID: GC04M057676

serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin...

(Previous names: serine protease inhibitor, Kazal type 2 (acrosin-trypsin...)

Explore 3 diseases affiliated with
SPINK2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Serine Peptidase Inhibitor, Kazal Type 2 (Acrosin-Trypsin Inhibitor)¹ ²
HUSI-II¹ ² ³
Epididymis Tissue Protein Li 172² ³
Serine Protease Inhibitor, Kazal Type 2 (Acrosin-Trypsin Inhibitor)¹
Serine Protease Inhibitor Kazal-Type 2²
Acrosin-Trypsin Inhibitor³

External Ids:	HGNC: 11245¹	Entrez Gene: 6691²	Ensembl: ENSG00000128040⁷	OMIM: 605753⁵	UniProtKB: P20155³

Export aliases for SPINK2 gene to outside databases

Previous GC identifers: GC04M057479 GC04M057637 GC04M057591 GC04M057516 GC04M057370 GC04M053629

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SPINK2:

This gene encodes a member of the family of serine protease inhibitors of the Kazal type (SPINK). The encoded protein

acts as a trypsin and acrosin inhibitor in the genital tract and is localized in the spermatozoa. The protein has been

associated with the progression of lymphomas. Alternative splicing results in multiple transcript variants. (provided

by RefSeq, Nov 2012)

UniProtKB/Swiss-Prot: ISK2_HUMAN, P20155

Function: Strong inhibitor of acrosin in male and/or female genital tract. Also inhibits trypsin

Gene Wiki entry for SPINK2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_022853.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SPINK2 gene promoter:
NRSF form 1 Brachyury NRSF form 2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SPINK2 promoter sequence

Search SABiosciences Chromatin IP Primers for SPINK2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPINK2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12 Ensembl cytogenetic band: 4q12 HGNC cytogenetic band: 4q12

SPINK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPINK2 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M057676: view genomic region (about GC identifiers)

Start:	57,676,026 bp from pter	End:	57,687,908 bp from pter
Size:	11,883 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ISK2_HUMAN, P20155 (See protein sequence)

Recommended Name: Serine protease inhibitor Kazal-type 2 precursor

Size: 84 amino acids; 9291 Da

Subcellular location: Secreted

1 PDB 3D structure from and Proteopedia for SPINK2:

2JXD (3D)

Secondary accessions: Q6FGH2

Explore the universe of human proteins at neXtProt for SPINK2: NX_P20155

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P20155

SPINK2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (6 alternative transcripts):

NP_001258647.1 NP_001258648.1 NP_001258649.1 NP_001258650.1 NP_001258651.1 NP_066937.1

ENSEMBL proteins:

ENSP00000248701 ENSP00000425961 ENSP00000423858

Human Recombinant Protein Products for SPINK2:

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	Uscn Proteins for SPINK2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

SPINK2 for ontologies About GeneDecksing

SPINK2 Antibody Products:

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Assay Products for SPINK2:

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	Uscn ELISAs and CLIAs for SPINK2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SPINK2 for domains About GeneDecksing

1 InterPro domain/family:

IPR002350 Prot_inh_Kazal

Graphical View of Domain Structure for InterPro Entry P20155

ProtoNet protein and cluster: P20155

1 Blocks protein family: IPB001239 Kazal-type serine protease inhibitor signature

UniProtKB/Swiss-Prot: ISK2_HUMAN, P20155

Similarity: Contains 1 Kazal-like domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ISK2_HUMAN, P20155

Function: Strong inhibitor of acrosin in male and/or female genital tract. Also inhibits trypsin

Genatlas biochemistry entry for SPINK2:

serine protease inhibitor,Kazal type 2 (acrosin-trypsin inhibitor)

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004866	endopeptidase inhibitor activity	TAS	8428671
GO:0004867	serine-type endopeptidase inhibitor activity	IEA	--

SPINK2 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for SPINK2:

Synthetic lethal with Ras

Synthetic lethal with c-Myc af

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Spink2):

cellular

endocrine/exocrine gland

reproductive system

SPINK2 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SPINK2

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPINK2
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate SPINK2:
		hsa-miR-7-1* hsa-miR-7-2*
		SwitchGear 3'UTR luciferase reporter plasmid: SPINK2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPINK2 (see all 7) OriGene shRNA RFP: SPINK2 OriGene siRNA: SPINK2
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPINK2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPINK2 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SPINK2
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In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for SPINK2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SPINK2

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0010951	negative regulation of endopeptidase activity	TAS	8428671

SPINK2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SPINK2
Search CenterWatch for drugs/clinical trials and news about SPINK2 / ISK2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SPINK2 gene (6 alternative transcripts):

NM_001271718.1 NM_001271719.1 NM_001271720.1 NM_001271721.1 NM_001271722.1 NM_021114.3

Unigene Cluster for SPINK2:

Serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)

Hs.98243 [show with all ESTs]

Unigene Representative Sequence: BM563686

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000509707 ENST00000248701(uc003hcg.1) ENST00000506738 ENST00000504762

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPINK2
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate SPINK2:
		hsa-miR-7-1* hsa-miR-7-2*
		SwitchGear 3'UTR luciferase reporter plasmid: SPINK2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPINK2 (see all 7) OriGene shRNA RFP: SPINK2 OriGene siRNA: SPINK2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPINK2
		Sirion Biotech Custom design and validation of potent shRNA sequences against SPINK2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPINK2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPINK2 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPINK2 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPINK2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPINK2

Additional cDNA sequence:

AK312222.1 BC022514.1 CR542135.1 GU727622.1 NR_073417.1 NR_073418.1 NR_073419.1 X57655.1

3 DOTS entries:

DT.444486 DT.100780011 DT.92421817

24/73 AceView cDNA sequences (see all 73):

AA973772 AA625888 BM314125 AW182819 CR542135 BC022514 AA779272 AW950531

BM313844 AA335752 CK905202 BG214688 AW072431 BG700147 BG193436 AA872176

BI520020 AA570635 BG193958 BI827169 AW082715 NM_021114 AA416641 X57655

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for SPINK2 About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4a	·	4b	·	4c
SP1:
SP2:					-		-
SP3:							-

ECgene alternative splicing isoforms for SPINK2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SPINK2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTAGTGATG

About this image

SPINK2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

HyStem+BMP4-induced 7SMOO32 cells (HyStem+BMP4 inductio...)

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SPINK2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPINK2

SOURCE GeneReport for Unigene cluster: Hs.98243

UniProtKB/Swiss-Prot: ISK2_HUMAN, P20155

Tissue specificity: Expressed in epididymis (at protein level)

SABiosciences Custom PCR Arrays for SPINK2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPINK2 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPINK2

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for SPINK2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for SPINK2 gene from 4/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Spink2^{1 , 5}	serine peptidase inhibitor, Kazal type 2^{1, 5}	66.25(n)¹ 58.75(a)¹		5 (41.53 cM)⁵ 69982¹ NM_183284.2¹ NP_899107.1¹ 77205107⁵
chicken (Gallus gallus)	Aves	ISK1L_CHICK⁶	Trypsin inhibitor ClTI-1	41(a)	1 ↔ 1	4(50767022-50769233)
lizard (Anolis carolinensis)	Reptilia	SPINK2⁶	--	53(a)	1 ↔ 1	GL343257.1(1419937-1603080)
zebrafish (Danio rerio)	Actinopterygii	zgc:158852⁶ CR381551.1⁶ (see all 4)	--	45(a) 43(a) (see all 4)	many → 1 many → 1 (see all 4)	14(19055668-19056708) 14(19497074-19497787)

ENSEMBL Gene Tree for SPINK2 (if available)
TreeFam Gene Tree for SPINK2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs77616647^1,2	C	--	57675552(+)	`ATTTTC/TGAGAC`	9	--	ds500¹		0	--	--	--	--
rs79371444^1,2	C	--	57675561(+)	`ACAGAC/G/TTCTCG`	9	--	ds500¹		0	--	--	--	--
rs149643984^1,2		--	57675620(+)	`ACCTCC/TGCCTC`	9	--	ds500¹		0	--	--	--	--
rs187613246^1,2		--	57675633(+)	`GGGTTC/TGAGCG`	9	--	ds500¹		0	--	--	--	--
rs144408508^1,2		--	57675634(+)	`GGTTCG/TAGCGA`	9	--	ds500¹		0	--	--	--	--
rs193214068^1,2		--	57675648(+)	`TCCTGC/TCTCAG`	9	--	ds500¹		0	--	--	--	--
rs148344552^1,2		--	57675660(+)	`CTCCCA/GAGTAG`	9	--	ds500¹		0	--	--	--	--
rs185075360^1,2		--	57675670(+)	`GCTGGA/GACTAC`	9	--	ds500¹		0	--	--	--	--
rs142191452^1,2		--	57675769(+)	`AGCTCA/GTGATA`	9	--	ds500¹		0	--	--	--	--
rs187510833^1,2		--	57675779(+)	`ACGCCC/TGCCTC`	9	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SPINK2 (57676026 - 57687908 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SPINK2: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPINK2

DNA2.0 Custom Variant and Variant Library Synthesis for SPINK2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SPINK2 for disorders           About GeneDecksing

OMIM gene information: 605753    OMIM disorders: --

3 diseases for SPINK2:    About MalaCards

celiac disease epididymitis infertility

Human Genome Epidemiology (HuGE) Navigator: SPINK2 (1 document)

Export disorders for SPINK2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SPINK2 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with SPINK2)

Utopia: connect your pdf to the dynamic
world of online information

Organization and sequence of the gene encoding the human acrosin- trypsin inhibitor (HUSI-II). (PubMed id 8428671)^{1, 2, 3} Moeritz A.... Fink E. (1993)
Identification of trypsin-inhibitory site and structure determination of human SPINK2 serine proteinase inhibitor. (PubMed id 19422058)^{1, 2, 9} Chen T.... Lyu P.-C. (2009)
Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PubMed id 20736409)^{1, 2} Li J.... Liu Y. (2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Molecular cloning and sequence analysis of the cDNA encoding the human acrosin-trypsin inhibitor (HUSI-II). (PubMed id 1704312)^{1, 2} Moeritz A.... Fink E. (1991)
Amino acid sequence elucidation of human acrosin-trypsin inhibitor (HUSI-II) reveals that Kazal-type proteinase inhibitors are structurally related to beta-subunits of glycoprotein hormones. (PubMed id 2226783)^{1, 2} Fink E.... Eulitz M. (1990)
The SPINK gene family and celiac disease susceptibility. (PubMed id 17333166)¹ Wapenaar M.C....Wijmenga C. (2007)
A germline-specific class of small RNAs binds mammali an Piwi proteins. (PubMed id 16751776)¹ Girard A....Carmell M.A. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
Gene expression patterns associated with infertility in humans and rodent models. (PubMed id 15120973)¹ Rockett J.C....Dix D.J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6691	HGNC: 11245	AceView: SPINK2	Ensembl:ENSG00000128040	euGenes: HUgn6691
ECgene: SPINK2	H-InvDB: SPINK2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SPINK2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SPINK2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SPINK2 gene:
Search GeneIP for patents involving SPINK2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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	Browse OriGene Antibodies		OriGene shRNA RFP for SPINK2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPINK2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPINK2
	OriGene Protein Over-expression Lysate for SPINK2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for SPINK2		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPINK2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPINK2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SPINK2		OriGene Custom Protein Services for SPINK2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPINK2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPINK2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPINK2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPINK2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPINK2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPINK2

	GenScript Custom Purified and Recombinant Proteins Services for SPINK2		GenScript cDNA clones with any tag delivered in your preferred vector for SPINK2
	GenScript Custom Assay Services for SPINK2		GenScript Custom Superior Antibodies Services for SPINK2
	GenScript Custom overexpressing Cell Line Services for SPINK2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

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	Regulatory tfbs in SPINK2 promoter
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Search Tocris compounds for SPINK2

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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
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	Antibodies for SPINK2
	See all of Abcam's Antibodies, Kits and Proteins for SPINK2
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Browse ProSpec Recombinant Proteins

SPINK2 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for SPINK2

	Gene Synthesis
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Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for SPINK2

	SwitchGear 3'UTR luciferase reporter plasmids for SPINK2
	SwitchGear Promoter luciferase reporter plasmids for SPINK2

Search ThermoFisher Antibodies for SPINK2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPINK2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SPINK2

Sirion Biotech Customized:

	stable knockdown cell line services for SPINK2
	inducible knockdown cell line services for SPINK2
	design and validation of potent shRNA sequences against SPINK2
	adenovirus for potent knockdown of SPINK2
	adenovirus for overexpression of SPINK2
	stable overexpressing cell line services for SPINK2
	inducible overexpressing cell line services for SPINK2

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SPINK2 gene at Home site.

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SPINK2 Gene

serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin...

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SPINK2 Gene

serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin...

Aliasesfor SPINK2 gene

Summariesfor SPINK2 gene

Genomic Viewsfor SPINK2 gene

Proteinsfor SPINK2 gene

Protein Domains /Familiesfor SPINK2 gene

Functionfor SPINK2 gene

Pathways & Interactionsfor SPINK2 gene

Drugs & Compoundsfor SPINK2 gene

Transcriptsfor SPINK2 gene

Expression for SPINK2 gene

Orthologsfor SPINK2 gene

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Genomic Variantsfor SPINK2 gene

Disorders / Diseasesfor SPINK2 gene

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Genome Databases showing SPINK2 gene

Other Databases showing SPINK2 gene

Specialized Databases showing SPINK2 gene

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Aliases
for SPINK2 gene

Summaries
for SPINK2 gene

Genomic Views
for SPINK2 gene

Proteins
for SPINK2 gene

Protein Domains /
Families
for SPINK2 gene

Function
for SPINK2 gene

Pathways & Interactions
for SPINK2 gene

Drugs & Compounds
for SPINK2 gene

Transcripts
for SPINK2 gene

Expression
for SPINK2 gene

Orthologs
for SPINK2 gene

Paralogs
for SPINK2 gene

Genomic Variants
for SPINK2 gene

Disorders / Diseases
for SPINK2 gene

Publications
for SPINK2 gene

Intellectual Property
for SPINK2 gene

Products
for SPINK2 gene