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Aliases for SPINK14 Gene

Aliases for SPINK14 Gene

  • Serine Peptidase Inhibitor, Kazal Type 14 (Putative) 2 3 5
  • SPINK5L2 3 4
  • Kazal Type Serine Protease Inhibitor 5-Like 2 3
  • Serine Protease Inhibitor Kazal-Type 14 3

External Ids for SPINK14 Gene

Previous GeneCards Identifiers for SPINK14 Gene

  • GC05P147549
  • GC05P142696

Summaries for SPINK14 Gene

GeneCards Summary for SPINK14 Gene

SPINK14 (Serine Peptidase Inhibitor, Kazal Type 14 (Putative)) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SPINK7.

UniProtKB/Swiss-Prot for SPINK14 Gene

  • May be a serine protease inhibitor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPINK14 Gene

Genomics for SPINK14 Gene

Regulatory Elements for SPINK14 Gene

Enhancers for SPINK14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F148473 0.9 Ensembl ENCODE 9.6 +305.8 305809 0.8 SMARCE1 RNF2 ZNF740 JUN CEBPB DPF2 RFX5 ARID1B JUND ATF3 FBXO38 LOC102546294 SPINK14 GC05M148466 ENSG00000251330
GH05F148205 0.8 FANTOM5 Ensembl 10.2 +37.2 37211 0.9 HNF4G ZBTB33 YY1 SPINK7 SPINK14 SPINK9 SPINK13 FBXO38 SPINK6 HMGN1P16
GH05F148192 0.5 FANTOM5 11.2 +24.5 24489 0.4 CEBPB EP300 SPINK6 FBXO38 SPINK14 SPINK7 SPINK9 LOC102546294
GH05F148134 0.4 ENCODE 11.7 -33.2 -33212 1.8 REST SPINK6 SPINK14 GC05M147950
GH05F148465 0.4 Ensembl 9.9 +297.5 297455 0.4 CEBPB SPINK9 SPINK7 SPINK14 SPINK6 GC05M148466 ENSG00000251330
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPINK14 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPINK14 Gene

148,168,546 bp from pter
148,175,619 bp from pter
7,074 bases
Plus strand

Genomic View for SPINK14 Gene

Genes around SPINK14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPINK14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPINK14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPINK14 Gene

Proteins for SPINK14 Gene

  • Protein details for SPINK14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine protease inhibitor Kazal-type 14
    Protein Accession:

    Protein attributes for SPINK14 Gene

    97 amino acids
    Molecular mass:
    11057 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPINK14 Gene

Post-translational modifications for SPINK14 Gene

Other Protein References for SPINK14 Gene

No data available for DME Specific Peptides for SPINK14 Gene

Domains & Families for SPINK14 Gene

Gene Families for SPINK14 Gene

Protein Domains for SPINK14 Gene


Suggested Antigen Peptide Sequences for SPINK14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Kazal-like domain.
  • Contains 1 Kazal-like domain.
genes like me logo Genes that share domains with SPINK14: view

Function for SPINK14 Gene

Molecular function for SPINK14 Gene

UniProtKB/Swiss-Prot Function:
May be a serine protease inhibitor.

Gene Ontology (GO) - Molecular Function for SPINK14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IBA --
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SPINK14: view
genes like me logo Genes that share phenotypes with SPINK14: view

Animal Models for SPINK14 Gene

MGI Knock Outs for SPINK14:

Animal Model Products

  • Taconic Biosciences Mouse Models for SPINK14

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SPINK14 Gene

Localization for SPINK14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPINK14 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPINK14 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for SPINK14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with SPINK14: view

Pathways & Interactions for SPINK14 Gene

SuperPathways for SPINK14 Gene

No Data Available

Interacting Proteins for SPINK14 Gene

Gene Ontology (GO) - Biological Process for SPINK14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IEA --
GO:1900004 negative regulation of serine-type endopeptidase activity IBA --
genes like me logo Genes that share ontologies with SPINK14: view

No data available for Pathways by source and SIGNOR curated interactions for SPINK14 Gene

Transcripts for SPINK14 Gene

mRNA/cDNA for SPINK14 Gene

(6) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPINK14 Gene

No ASD Table

Relevant External Links for SPINK14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPINK14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPINK14 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPINK14 Gene:


SOURCE GeneReport for Unigene cluster for SPINK14 Gene:

genes like me logo Genes that share expression patterns with SPINK14: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SPINK14 Gene

Orthologs for SPINK14 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPINK14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPINK14 34 35
  • 98.63 (n)
(Rattus norvegicus)
Mammalia Spink14 34
  • 76.63 (n)
(Mus musculus)
Mammalia Spink14 34 16 35
  • 75.35 (n)
(Canis familiaris)
Mammalia SPINK14 35
  • 74 (a)
Species where no ortholog for SPINK14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPINK14 Gene

Gene Tree for SPINK14 (if available)
Gene Tree for SPINK14 (if available)

Paralogs for SPINK14 Gene

Paralogs for SPINK14 Gene

(7) SIMAP similar genes for SPINK14 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SPINK14: view

Variants for SPINK14 Gene

Sequence variations from dbSNP and Humsavar for SPINK14 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10036424 -- 148,149,937(+) ATTTT(C/T)GTAGA intron-variant
rs10037701 -- 148,161,600(+) ATTCT(C/T)ATTCT intron-variant
rs10038045 -- 148,152,213(+) GGTGT(C/T)ATCAT intron-variant, downstream-variant-500B
rs10044512 -- 148,155,785(+) acaca(C/T)tggtg intron-variant
rs10044836 -- 148,153,630(+) AGTCt(G/T)tatta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPINK14 Gene

Variant ID Type Subtype PubMed ID
dgv10110n54 CNV loss 21841781
esv21549 CNV gain+loss 19812545
esv2505853 CNV deletion 19546169
esv2602125 CNV loss 19546169
esv2618615 OTHER inversion 19546169
esv3607101 CNV loss 21293372
esv3607102 CNV loss 21293372
esv5789 OTHER inversion 19470904
esv6569 OTHER inversion 19470904
nsv1069108 OTHER inversion 25765185
nsv1074338 CNV deletion 25765185
nsv1116474 OTHER inversion 24896259
nsv1140365 OTHER inversion 24896259
nsv1145831 OTHER inversion 26484159
nsv599941 CNV loss 21841781
nsv819370 CNV gain 19587683
nsv820675 CNV deletion 20802225
nsv823293 CNV loss 20364138
nsv823294 CNV gain+loss 20364138
nsv823295 CNV loss 20364138
nsv830515 CNV gain+loss 17160897
nsv950424 CNV deletion 24416366

Variation tolerance for SPINK14 Gene

Residual Variation Intolerance Score: 66.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.20; 4.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPINK14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPINK14 Gene

Disorders for SPINK14 Gene

Relevant External Links for SPINK14

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SPINK14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPINK14 Gene

Publications for SPINK14 Gene

  1. A genomic analysis of rat proteases and protease inhibitors. (PMID: 15060002) Puente X.S. … Lopez-Otin C. (Genome Res. 2004) 3 4 64
  2. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PMID: 17903301) Vasan R.S. … Benjamin E.J. (BMC Med. Genet. 2007) 46 64
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 4 64

Products for SPINK14 Gene

Sources for SPINK14 Gene

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