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Aliases for SPINK14 Gene

Aliases for SPINK14 Gene

  • Serine Peptidase Inhibitor, Kazal Type 14 (Putative) 2 3
  • SPINK5L2 3 4
  • Kazal Type Serine Protease Inhibitor 5-Like 2 3
  • Serine Protease Inhibitor Kazal-Type 14 3

External Ids for SPINK14 Gene

Summaries for SPINK14 Gene

GeneCards Summary for SPINK14 Gene

SPINK14 (Serine Peptidase Inhibitor, Kazal Type 14 (Putative)) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity.

UniProtKB/Swiss-Prot for SPINK14 Gene

  • May be a serine protease inhibitor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPINK14 Gene

Genomics for SPINK14 Gene

Genomic Location for SPINK14 Gene

148,168,546 bp from pter
148,175,619 bp from pter
7,074 bases
Plus strand

Genomic View for SPINK14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPINK14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPINK14 Gene

No data available for Regulatory Elements for SPINK14 Gene

Proteins for SPINK14 Gene

  • Protein details for SPINK14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine protease inhibitor Kazal-type 14
    Protein Accession:
    Secondary Accessions:

    Protein attributes for SPINK14 Gene

    97 amino acids
    Molecular mass:
    11057 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPINK14 Gene

Proteomics data for SPINK14 Gene at MOPED

Post-translational modifications for SPINK14 Gene

Other Protein References for SPINK14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPINK14 Gene

Domains for SPINK14 Gene

Gene Families for SPINK14 Gene

  • SPINK :Serine peptidase inhibitors, Kazal type

Protein Domains for SPINK14 Gene


Suggested Antigen Peptide Sequences for SPINK14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Kazal-like domain.:
    • Q6IE38
genes like me logo Genes that share domains with SPINK14: view

Function for SPINK14 Gene

Molecular function for SPINK14 Gene

UniProtKB/Swiss-Prot Function: May be a serine protease inhibitor.

Gene Ontology (GO) - Molecular Function for SPINK14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SPINK14: view

Phenotypes for SPINK14 Gene

GenomeRNAi human phenotypes for SPINK14:
genes like me logo Genes that share phenotypes with SPINK14: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SPINK14 Gene

Localization for SPINK14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPINK14 Gene


Subcellular locations from

Jensen Localization Image for SPINK14 Gene COMPARTMENTS Subcellular localization image for SPINK14 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for SPINK14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with SPINK14: view

Pathways for SPINK14 Gene

SuperPathways for SPINK14 Gene

No Data Available

Interacting Proteins for SPINK14 Gene

Gene Ontology (GO) - Biological Process for SPINK14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with SPINK14: view

No data available for Pathways by source for SPINK14 Gene

Transcripts for SPINK14 Gene

mRNA/cDNA for SPINK14 Gene

(2) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SPINK14 Gene

No ASD Table

Relevant External Links for SPINK14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPINK14 Gene

mRNA expression in normal human tissues for SPINK14 Gene

SOURCE GeneReport for Unigene cluster for SPINK14 Gene Hs.553815

genes like me logo Genes that share expressions with SPINK14: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for SPINK14 Gene

Orthologs for SPINK14 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPINK14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPINK14 35
  • 98.63 (n)
  • 98.97 (a)
SPINK14 36
  • 99 (a)
(Canis familiaris)
Mammalia SPINK14 36
  • 74 (a)
(Mus musculus)
Mammalia Spink14 35
  • 75.35 (n)
  • 66.67 (a)
Spink14 16
Spink14 36
  • 67 (a)
(Rattus norvegicus)
Mammalia Spink14 35
  • 76.63 (n)
  • 67.01 (a)
Species with no ortholog for SPINK14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPINK14 Gene

Gene Tree for SPINK14 (if available)
Gene Tree for SPINK14 (if available)

Paralogs for SPINK14 Gene

Selected SIMAP similar genes for SPINK14 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SPINK14: view

No data available for Paralogs for SPINK14 Gene

Variants for SPINK14 Gene

Sequence variations from dbSNP and Humsavar for SPINK14 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1029884 -- 148,171,857(+) AAGCT(C/G)AGTTC intron-variant
rs1156195 -- 148,171,375(+) CTATG(C/T)AAGTT intron-variant
rs2400493 -- 148,176,090(+) AAAAC(A/G)TATAG downstream-variant-500B
rs3036798 -- 148,172,801(+) TGACA(-/AC/CA)CGTCA intron-variant
rs4254894 -- 148,167,588(+) ATATG(C/T)GATGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SPINK14 Gene

Variant ID Type Subtype PubMed ID
nsv883015 CNV Loss 21882294
nsv830515 CNV Gain+Loss 17160897
esv2602125 CNV Loss 19546169
esv2505853 CNV Deletion 19546169
nsv823293 CNV Loss 20364138
nsv823294 CNV Gain+Loss 20364138
nsv823295 CNV Loss 20364138
nsv819370 CNV Gain 19587683
esv6569 OTHER Inversion 19470904
esv21549 CNV Gain+Loss 19812545
nsv820675 CNV Deletion 20802225
esv2618615 OTHER Inversion 19546169
esv5789 OTHER Inversion 19470904

Relevant External Links for SPINK14 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPINK14 Gene

Disorders for SPINK14 Gene

Relevant External Links for SPINK14

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with SPINK14: view

No data available for UniProtKB/Swiss-Prot for SPINK14 Gene

Publications for SPINK14 Gene

  1. A genomic analysis of rat proteases and protease inhibitors. (PMID: 15060002) Puente X.S. … Lopez-Otin C. (Genome Res. 2004) 3 4
  2. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PMID: 17903301) Vasan R.S. … Benjamin E.J. (BMC Med. Genet. 2007) 48
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 4

Products for SPINK14 Gene

Sources for SPINK14 Gene

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