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Aliases for SPINK13 Gene

Aliases for SPINK13 Gene

  • Serine Peptidase Inhibitor, Kazal Type 13 (Putative) 2 3
  • Hepatitis B Virus DNA Polymerase Transactivated Serine Protease Inhibitor 3 4
  • Hepatitis B Virus (HBV) DNA Polymerase Transactivated Protein 1 2 3
  • Serine Protease Inhibitor Kazal-Type 5-Like 3 3 4
  • HBVDNAPTP1 3 4
  • HESPINTOR 3 4
  • SPINK5L3 3 4
  • Hepatitis B Virus DNA Polymerase Transactivated Human Serine Protease Inhibitor 3
  • Serine Protease Inhibitor Kazal-Type 13 3
  • LiESP6 3

External Ids for SPINK13 Gene

Summaries for SPINK13 Gene

GeneCards Summary for SPINK13 Gene

SPINK13 (Serine Peptidase Inhibitor, Kazal Type 13 (Putative)) is a Protein Coding gene. Diseases associated with SPINK13 include hepatitis b and hepatitis. GO annotations related to this gene include serine-type endopeptidase inhibitor activity.

UniProtKB/Swiss-Prot for SPINK13 Gene

  • May be a serine protease inhibitor (By similarity). Essential for sperm maturation and fertility. Inhibits sperm acrosome reaction, protecting sperm from premature reaction (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPINK13 Gene

Genomics for SPINK13 Gene

Genomic Location for SPINK13 Gene

Start:
148,268,180 bp from pter
End:
148,286,254 bp from pter
Size:
18,075 bases
Orientation:
Plus strand

Genomic View for SPINK13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPINK13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPINK13 Gene

No data available for Regulatory Elements for SPINK13 Gene

Proteins for SPINK13 Gene

  • Protein details for SPINK13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q1W4C9-ISK13_HUMAN
    Recommended name:
    Serine protease inhibitor Kazal-type 13
    Protein Accession:
    Q1W4C9
    Secondary Accessions:
    • A1A4Y2

    Protein attributes for SPINK13 Gene

    Size:
    94 amino acids
    Molecular mass:
    11051 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPINK13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPINK13 Gene

Proteomics data for SPINK13 Gene at MOPED

Post-translational modifications for SPINK13 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn55

Other Protein References for SPINK13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPINK13 Gene

Domains for SPINK13 Gene

Gene Families for SPINK13 Gene

HGNC:
  • SPINK :Serine peptidase inhibitors, Kazal type

Protein Domains for SPINK13 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPINK13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q1W4C9

UniProtKB/Swiss-Prot:

ISK13_HUMAN
Domain:
  • Contains 1 Kazal-like domain.:
    • Q1W4C9
genes like me logo Genes that share domains with SPINK13: view

Function for SPINK13 Gene

Molecular function for SPINK13 Gene

UniProtKB/Swiss-Prot Function: May be a serine protease inhibitor (By similarity). Essential for sperm maturation and fertility. Inhibits sperm acrosome reaction, protecting sperm from premature reaction (By similarity).

Gene Ontology (GO) - Molecular Function for SPINK13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SPINK13: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SPINK13 Gene

Localization for SPINK13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPINK13 Gene

Secreted. Note=Secreted into the lumen of the initial segment of the epididymis and binds to sperm. In the initial segment of epididymis, localizes on the dorsal surface of the acrosomal region of sperm, gradually becomes more restricted to the acrosomal region in spermatozoa during epididymal transit (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPINK13 Gene COMPARTMENTS Subcellular localization image for SPINK13 gene
Compartment Confidence
extracellular 3
nucleus 1

Gene Ontology (GO) - Cellular Components for SPINK13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with SPINK13: view

Pathways for SPINK13 Gene

SuperPathways for SPINK13 Gene

No Data Available

Interacting Proteins for SPINK13 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000381468%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000381468 for SPINK13 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for SPINK13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:1902225 negative regulation of acrosome reaction ISS --
genes like me logo Genes that share ontologies with SPINK13: view

No data available for Pathways by source for SPINK13 Gene

Transcripts for SPINK13 Gene

mRNA/cDNA for SPINK13 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPINK13 Gene

Serine peptidase inhibitor, Kazal type 13 (putative):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPINK13 Gene

No ASD Table

Relevant External Links for SPINK13 Gene

GeneLoc Exon Structure for
SPINK13
ECgene alternative splicing isoforms for
SPINK13

Expression for SPINK13 Gene

mRNA expression in normal human tissues for SPINK13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPINK13 Gene

This gene is overexpressed in Artery - Tibial (4.3) and Artery - Coronary (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SPINK13 Gene

SOURCE GeneReport for Unigene cluster for SPINK13 Gene Hs.483771

genes like me logo Genes that share expressions with SPINK13: view

No data available for mRNA Expression by UniProt/SwissProt for SPINK13 Gene

Orthologs for SPINK13 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for SPINK13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPINK13 35
  • 99.29 (n)
  • 97.87 (a)
SPINK13 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spink13 35
  • 70.41 (n)
  • 55.06 (a)
Spink13 16
Spink13 36
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spink13 35
  • 69.18 (n)
  • 52.69 (a)
Species with no ortholog for SPINK13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPINK13 Gene

ENSEMBL:
Gene Tree for SPINK13 (if available)
TreeFam:
Gene Tree for SPINK13 (if available)

Paralogs for SPINK13 Gene

Selected SIMAP similar genes for SPINK13 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPINK13: view

No data available for Paralogs for SPINK13 Gene

Variants for SPINK13 Gene

Sequence variations from dbSNP and Humsavar for SPINK13 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs6873262 -- 148,267,307(+) TACCA(A/G)AAAGG upstream-variant-2KB
rs6873279 -- 148,267,352(+) TCTAA(A/G)AAGAC upstream-variant-2KB
rs6873282 -- 148,267,355(+) AAGAA(A/G)ACTGT upstream-variant-2KB
rs6873420 -- 148,267,400(+) ACTTA(A/G)AGCAA upstream-variant-2KB
rs6874673 -- 148,267,490(+) TAGCT(C/T)CAGCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SPINK13 Gene

Variant ID Type Subtype PubMed ID
nsv883015 CNV Loss 21882294
dgv6358n71 CNV Gain 21882294
dgv726n27 CNV Gain 19166990

Relevant External Links for SPINK13 Gene

HapMap Linkage Disequilibrium report
SPINK13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPINK13 Gene

Disorders for SPINK13 Gene

(2) MalaCards Diseases for SPINK13 Gene

Search for SPINK13 Gene in MalaCards »

Relevant External Links for SPINK13

Genetic Association Database (GAD)
SPINK13
genes like me logo Genes that share disorders with SPINK13: view

No data available for UniProtKB/Swiss-Prot for SPINK13 Gene

Publications for SPINK13 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  3. A genomic analysis of rat proteases and protease inhibitors. (PMID: 15060002) Puente X.S. … Lopez-Otin C. (Genome Res. 2004) 3
  4. Transcriptome analysis of a cDNA library from adult human epididymis. (PMID: 18390568) Li J.Y. … Zhang Y.L. (DNA Res. 2008) 3
  5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3

Products for SPINK13 Gene

Sources for SPINK13 Gene

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