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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPINK1 Gene

protein-coding   GIFtS: 60
GCID: GC05M147184

Serine Peptidase Inhibitor, Kazal Type 1

(Previous names: serine protease inhibitor, Kazal type 1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Serine Peptidase Inhibitor, Kazal Type 11 2     Tumor-Associated Trypsin Inhibitor2 3
PSTI2 3 5     PCTT2 5
TATI2 3 5     Spink32
Serine Protease Inhibitor, Kazal Type 11 2     TCP2
Serine Protease Inhibitor Kazal-Type 12 3     Pancreatic Secretory Trypsin Inhibitor2

External Ids:    HGNC: 112441   Entrez Gene: 66902   Ensembl: ENSG000001642667   OMIM: 1677905   UniProtKB: P009953   

Export aliases for SPINK1 gene to outside databases

Previous GC identifers: GC05M147236 GC05M147785 GC05M147232 GC05M142351


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SPINK1 Gene:
The protein encoded by this gene is a trypsin inhibitor, which is secreted from pancreatic acinar cells into
pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of
zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary
pancreatitis and tropical calcific pancreatitis. (provided by RefSeq, Oct 2008)

GeneCards Summary for SPINK1 Gene: 
SPINK1 (serine peptidase inhibitor, Kazal type 1) is a protein-coding gene. Diseases associated with SPINK1 include tropical calcific pancreatitis, and alcoholic pancreatitis, and among its related super-pathways are Integrated Cancer pathway. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and endopeptidase inhibitor activity.

UniProtKB/Swiss-Prot: ISK1_HUMAN, P00995
Function: This is a trypsin inhibitor, its physiological function is to prevent the trypsin-catalyzed premature
activation of zymogens within the pancreas

Gene Wiki entry for SPINK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_029289.11  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPINK1 gene promoter:
         COUP-TF1   p300   Brachyury   POU3F1   COUP   HNF-4alpha2   HNF-3beta   HNF-4alpha1   MZF-1   COUP-TF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPINK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SPINK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPINK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q32   Ensembl cytogenetic band:  5q32   HGNC cytogenetic band: 5q32

SPINK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPINK1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M147184:  view genomic region     (about GC identifiers)

Start:
147,204,131 bp from pter      End:
147,211,349 bp from pter
Size:
7,219 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ISK1_HUMAN, P00995 (See protein sequence)
Recommended Name: Pancreatic secretory trypsin inhibitor precursor  
Size: 79 amino acids; 8507 Da
Subcellular location: Secreted
3 PDB 3D structures from and Proteopedia for SPINK1:
1CGI (3D)        1CGJ (3D)        1HPT (3D)    

Explore the universe of human proteins at neXtProt for SPINK1: NX_P00995

Explore proteomics data for SPINK1 at MOPED 

SPINK1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

SPINK1 Protein Expression

REFSEQ proteins: NP_003113.2  
ENSEMBL proteins: 
 ENSP00000296695   ENSP00000427376  

Human Recombinant Protein Products for SPINK1: 
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OriGene Protein Over-expression Lysate for SPINK1
OriGene Custom MassSpec 
OriGene Custom Protein Services for SPINK1
GenScript Custom Purified and Recombinant Proteins Services for SPINK1
Novus Biologicals SPINK1 Proteins
Novus Biologicals SPINK1 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for SPINK1 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

SPINK1 for ontologies           About GeneDecksing



SPINK1 Antibody Products: 
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Novus Biologicals SPINK1 Antibodies
Abcam antibodies for SPINK1
Cloud-Clone Corp. Antibodies for SPINK1 
Search ThermoFisher Antibodies for SPINK1
LSBio Antibodies in human, mouse, rat for SPINK1 

Assay Products for SPINK1: 
Browse Kits and Assays available from EMD Millipore
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GenScript Custom Assay Services for SPINK1
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for SPINK1 
Cloud-Clone Corp. CLIAs for SPINK1


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
SPINK: Serine peptidase inhibitors, Kazal type

2 InterPro protein domains:
 IPR002350 Kazal_dom
 IPR001239 Prot_inh_Kazal-m

Graphical View of Domain Structure for InterPro Entry P00995

ProtoNet protein and cluster: P00995

1 Blocks protein domain: IPB001239 Kazal-type serine protease inhibitor signature

UniProtKB/Swiss-Prot: ISK1_HUMAN, P00995
Similarity: Contains 1 Kazal-like domain


SPINK1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: ISK1_HUMAN, P00995
Function: This is a trypsin inhibitor, its physiological function is to prevent the trypsin-catalyzed premature
activation of zymogens within the pancreas

     Genatlas biochemistry entry for SPINK1:
serine protease inhibitor,Kazal type 1,unlikely to be involved in hereditary and sporadic pancreatitis

     Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004866endopeptidase inhibitor activity TAS7142173
GO:0004867serine-type endopeptidase inhibitor activity IEA--
GO:0005515protein binding IPI14507909
GO:0030414peptidase inhibitor activity ----
     
SPINK1 for ontologies           About GeneDecksing


Phenotypes:
     8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Spink3):
 digestive/alimentary  endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism 
 immune system  integument  mortality/aging 

SPINK1 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Spink3tm1Kymm for SPINK1

   inGenious Targeting Laboratory - Custom generated mouse model solutions for SPINK1 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SPINK1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPINK1 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPINK1 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPINK1
1 QIAGEN miScript miRNA Assays for microRNA that regulate SPINK1:
hsa-miR-4272
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for SPINK1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPINK1

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for SPINK1
Sirion Biotech Customized adenovirus for overexpression of SPINK1

Clone
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Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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OriGene ORF clones in mouse, rat for SPINK1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: SPINK1 (NM_003122)
Sino Biological Human cDNA Clone for SPINK1
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPINK1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPINK1
Sirion Biotech Customized lentivirus for stable overexpression of SPINK1 
                     Customized lentivirus expression plasmids for stable overexpression of SPINK1 

Cell Line
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GenScript Custom overexpressing Cell Line Services for SPINK1
Search LifeMap BioReagents cell lines for SPINK1
In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPINK1


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for SPINK1 About                                                                                                See pathways by source

SuperPathContained pathways About
1Prostate Cancer
Prostate Cancer0.32


1 BioSystems Pathway for SPINK1
    Prostate Cancer



Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SPINK1

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

5 Interacting proteins for SPINK1 (P009952, 3 ENSP000002966954) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
CTRCQ998953, ENSP000003651164I2D: score=2 STRING: ENSP00000365116
ELNP155023, ENSP000002520344I2D: score=2 STRING: ENSP00000252034
NRSN1Q8IZ573, ENSP000003677524I2D: score=1 STRING: ENSP00000367752
TMPRSS15P980733, ENSP000002848854I2D: score=1 STRING: ENSP00000284885
--P007662MINT-25044
About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0010466negative regulation of peptidase activity ----
GO:0010751negative regulation of nitric oxide mediated signal transduction IEA--
GO:0010951negative regulation of endopeptidase activity ----
GO:0050732negative regulation of peptidyl-tyrosine phosphorylation IEA--
GO:0060046regulation of acrosome reaction IEA--

SPINK1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SPINK1 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SPINK1 (ISK1)

5 Novoseek inferred chemical compound relationships for SPINK1 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
trypsinogen 94.4 64 16327984 (5), 11938439 (2), 12529713 (2), 12939655 (2) (see all 39)
serine 67.5 109 1669448 (3), 7510795 (3), 19737965 (2), 15980664 (2) (see all 57)
creatinine 4.47 12 14633748 (3), 9453997 (2), 14733412 (2), 11499560 (1) (see all 7)
calcium 0 3 16497624 (1), 14641934 (1), 12483248 (1)
fluoride 0 3 14633748 (1), 16923094 (1)

Search CenterWatch for drugs/clinical trials and news about SPINK1 / ISK1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SPINK1 gene: 
NM_003122.3  

Unigene Cluster for SPINK1:

Serine peptidase inhibitor, Kazal type 1
Hs.407856  [show with all ESTs]
Unigene Representative Sequence: AA652500
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000296695(uc003los.2) ENST00000505722 ENST00000510027
miRNA
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1 QIAGEN miScript miRNA Assays for microRNA that regulate SPINK1:
hsa-miR-4272
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for SPINK1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPINK1
Clone
Products:
     
OriGene clones in human, mouse for SPINK1 (see all 6)
OriGene ORF clones in mouse, rat for SPINK1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: SPINK1 (NM_003122)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPINK1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPINK1
Sirion Biotech Customized lentivirus for stable overexpression of SPINK1 
                     Customized lentivirus expression plasmids for stable overexpression of SPINK1 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for SPINK1
OriGene qSTAR qPCR primer pairs in human, mouse for SPINK1
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPINK1
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPINK1
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPINK1

Additional mRNA sequence: 

BC025790.1 Y00705.1 

4 DOTS entries:

DT.412800  DT.100650810  DT.100646430  DT.427385 

24/91 AceView cDNA sequences (see all 91):

BU581710 NM_003122 BM843311 AA436233 CB159576 BU581519 BC025790 BM843236 
CK905024 BG141336 AI362470 AI362622 BM855672 AA845156 BM855648 BM090732 
BM830452 BX498806 AY358656 AW005713 AA612829 Y00705 AA436232 NM_206966 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SPINK1 expression in normal human tissues (normalized intensities)      SPINK1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAGGTAACAG
SPINK1 Expression
About this image


SPINK1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/10 selected tissues (see all 10) fully expand
 
 Pancreas (Endocrine System)    fully expand to see all 3 entries
         pancreas ; exocrine glandular cells   
         Pancreatic Islet   
 
 Kidney (Urinary System)
         Presumptive Podocytes Podocyte Layer
 
 Bone (Muscoskeletal System)
         HyStem+BMP4-induced E15 cells
 
 Mesoderm (Gastrulation Derivatives)
         PureStem Z11, Meso Progenitor
 
 Cartilage (Muscoskeletal System)
         HyStem+BMP4-induced E15 cells

See SPINK1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPINK1

SOURCE GeneReport for Unigene cluster: Hs.407856
    SABiosciences Expression via Pathway-Focused PCR Array including SPINK1: 
          Lung Cancer in human mouse rat

Primer
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OriGene qPCR primer pairs and template standards for SPINK1
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QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPINK1
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPINK1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPINK1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for SPINK1 gene from 1/7 species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Spink31 , 5 serine peptidase inhibitor, Kazal type 31, 5 74.26(n)1
69.62(a)1
  18 (23.47 cM)5
207301  NM_009258.51  NP_033284.11 
 437280695 


ENSEMBL Gene Tree for SPINK1 (if available)
TreeFam Gene Tree for SPINK1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for SPINK1 gene
10 SIMAP similar genes for SPINK1 using alignment to 4 protein entries:     ISK1_HUMAN (see all proteins):
SPINK9    SPINK5    SPINK6    AGRN    SPINK2    SPINK14
TMEFF2    SPINK4    HEL-S-48e    SPINK13

SPINK1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/211 SNPs in SPINK1 are shown (see all 211)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 5 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0116884
Pancreatitis (PCTT)4--see VAR_0116882 L P mis40--------
rs171073151,2,4
C,F,HTropical calcific pancreatitis (TCP)4 pathogenic1147483387(-) TTACAA/GTGAAC 2 N S mis1 ese313Minor allele frequency- G:0.01NA NS EA EU 7121
rs358777201,2,4
C,FPancreatitis (PCTT)4 probable-non-pathogenic1147486814(-) GCCTTG/CGCCCT 2 /F /L mis15Minor allele frequency- C:0.03NA WA EU 6057
rs1119668331,2
C,Fnon-pathogenic1147483325(+) ATTGGA/C/GATAAG 2 P S mis13CSA NA EU 5856
rs1048939391,2
Cpathogenic1147486809(-) GGCCCC/G/TGTTGA 3 P R L mis10--------
rs1048939381,2
Cpathogenic1147486848(-) AGCCAC/TGAAGG 2 T M mis10--------
rs1416342961,2
C,Funknown1147483294(+) CTCACC/TGATTT 2 Q R mis12Minor allele frequency- T:0.00NA EU 5673
VAR_0116904
----see VAR_0116902 P S mis40--------
rs1132328021,2
F--147205106(+) TTCAAG/ATGATT 1 -- int11Minor allele frequency- A:0.50CSA 2
rs1840478431,2
--147479479(+) CCAGCC/TACAAT 1 -- ds50010--------

HapMap Linkage Disequilibrium report for SPINK1 (147204131 - 147211349 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for SPINK1: --

Human Gene Mutation Database (HGMD): SPINK1

Locus Specific Mutation Databases (LSDB): SPINK1
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing SPINK1
DNA2.0 Custom Variant and Variant Library Synthesis for SPINK1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 167790   
OMIM disorders: 167800  608189  
UniProtKB/Swiss-Prot: ISK1_HUMAN, P00995
  • Pancreatitis (PCTT) [MIM:167800]: A disease characterized by the presence of calculi in pancreatic ducts.
    It causes severe abdominal pain attacks. Note=The disease is caused by mutations affecting the gene represented
    in this entry
  • Tropical calcific pancreatitis (TCP) [MIM:608189]: Idiopathic, juvenile, nonalcoholic form of chronic
    pancreatitis widely prevalent in several tropical countries. It can be associated with fibrocalculous pancreatic
    diabetes (FCPD) depending on both environmental and genetic factors. TCP differs from alcoholic pancreatitis by a
    much younger age of onset, pancreatic calcification, a high incidence of insulin dependent but ketosis resistant
    diabetes mellitus, and an exceptionally high incidence of pancreatic cancer. Note=Disease susceptibility is
    associated with variations affecting the gene represented in this entry

  • 20/53 diseases for SPINK1 (see all 53):    About MalaCards
    tropical calcific pancreatitis    alcoholic pancreatitis    parotitis    biliary tract disease
    spink1-related hereditary pancreatitis    hereditary pancreatitis    acute pancreatitis    pancreatic diseases
    recurrent acute pancreatitis    pancreatitis    ovarian cyst    citrullinemia
    intestinal pseudo-obstruction    netherton syndrome    pancreatic cancer    fibrosarcoma
    primary hyperparathyroidism    hypercalcemia    cervical adenocarcinoma    lactic acidosis

    3 diseases from the University of Copenhagen DISEASES database for SPINK1:
    Pancreatitis     Pancreatic cancer     Cystic fibrosis

    SPINK1 for disorders           About GeneDecksing

    10/55 Novoseek inferred disease relationships for SPINK1 gene (see all 55)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreatitis hereditary 92.6 14 17274009 (2), 15084977 (2), 17613931 (1), 19106771 (1) (see all 10)
    chronic pancreatitis 91.4 145 11578065 (5), 11950817 (4), 14641934 (4), 18978175 (3) (see all 77)
    pancreatitis 86.9 105 12560856 (4), 18076731 (4), 10982753 (3), 12743777 (3) (see all 50)
    acute recurrent pancreatitis 83.3 4 19844201 (1), 19593166 (1), 20335783 (1)
    pancreatitis alcoholic 77.9 4 18182741 (2), 18336667 (1), 12822871 (1)
    acute pancreatitis 67.5 14 15782101 (2), 15238770 (2), 17625278 (1), 19844201 (1) (see all 9)
    pancreatic diseases 66.9 9 1791319 (2), 15238770 (1), 1780691 (1), 12120202 (1) (see all 7)
    pancreatic cancer 66.3 33 19737965 (4), 8207049 (4), 15084977 (4), 12649567 (3) (see all 13)
    cystic fibrosis 63.9 43 11938439 (2), 12939655 (2), 1886891 (1), 15758663 (1) (see all 27)
    pancreas divisum 61.2 6 19593166 (3), 17625278 (1)

    Genetic Association Database (GAD): SPINK1
    Human Genome Epidemiology (HuGE) Navigator: SPINK1 (71 documents)

    Export disorders for SPINK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPINK1 gene, integrated from 9 sources (see all 315) (see top 10):
    (articles sorted by number of sources associating them with SPINK1)
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    1. Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis. (PubMed id 10835640)1, 2, 4, 9 Witt H.... Becker M. (2000)
    2. SPINK1 is a susceptibility gene for fibrocalculous pancreatic diabetes in subjects from the Indian subcontinent. (PubMed id 12187509)1, 2, 4 Hassan Z.... Hitman G.A. (2002)
    3. [Mutations of SPINK1 and PRSS1 gene in Korean patients with chronic pancreatitis] (PubMed id 15329520)1, 4, 9 Lee K.H....Kim C.Y. (2004)
    4. SPINK1, ADH2, and ALDH2 gene variants and alcoholic chronic pancreatitis in Japan. (PubMed id 18336671)1, 4, 9 Shimosegawa T....Masamune A. (2008)
    5. Common SPINK-1 mutations do not predispose to the dev elopment of non-alcoholic fatty liver disease. (PubMed id 19502653)1, 4, 9 Oruc N....Akarca U.S. (2009)
    6. Mutations in the serine protease inhibitor Kazal Type 1 (SPINK1) gene in Japanese patients with pancreatitis. (PubMed id 15980664)1, 4, 9 Kume K....Shimosegawa T. (2005)
    7. The role of CFTR and SPINK-1 mutations in pancreatic disorders in HIV-positive patients: a case-control study. (PubMed id 15238770)1, 4, 9 Felley C....Frossard J.L. (2004)
    8. Mutations in serine protease inhibitor Kazal type 1 are strongly associated with chronic pancreatitis. (PubMed id 11950817)1, 4, 9 Drenth J.P....Jansen J.B. (2002)
    9. Identification of CFTR, PRSS1, and SPINK1 mutations in 381 patients with pancreatitis. (PubMed id 17003641)1, 4, 9 Keiles S. and Kammesheidt A. (2006)
    10. SPINK1 gene mutations and pancreatitis in Japan. (PubMed id 16958672)1, 4, 9 Shimosegawa T....Masamune A. (2006)
    11. Absence of PRSS1 mutations and association of SPINK1 trypsin inhibitor mutations in hereditary and non-hereditary chronic pancreatitis. (PubMed id 15082592)1, 4, 9 Chandak G.R....Singh L. (2004)
    12. Mutations in the SPINK1 gene in idiopathic pancreatitis Italian patients. (PubMed id 12825076)1, 4, 9 Gomez-Lira M....Pignatti P.F. (2003)
    13. SPINK1 and PRSS1 mutations in benign pancreatic hyperenzymemia. (PubMed id 18580441)1, 4, 9 Gullo L....Malesci A. (2008)
    14. Pancreatitis risk in primary hyperparathyroidism: relation to mutations in the SPINK1 trypsin inhibitor (N34S) and the cystic fibrosis gene. (PubMed id 18076731)1, 4, 9 Felderbauer P....Schmidt W.E. (2008)
    15. Contribution of the CFTR gene, the pancreatic secretory trypsin inhibitor gene (SPINK1) and the cationic trypsinogen gene (PRSS1) to the etiology of recurrent pancreatitis. (PubMed id 17489851)1, 4, 9 Tzetis M....Nousia-Arvanitakis S. (2007)
    16. Differential roles of the SPINK1 gene mutations in alcoholic and nonalcoholic chronic pancreatitis. (PubMed id 17238043)1, 4, 9 Masamune A....Shimosegawa T. (2007)
    17. Two novel severe mutations in the pancreatic secretory trypsin inhibitor gene (SPINK1) cause familial and/or hereditary pancreatitis. (PubMed id 14722925)1, 4, 9 Le Marechal C....Ferec C. (2004)
    18. CFTR, PRSS1 and SPINK1 mutations in the development of pancreatitis in Brazilian patients. (PubMed id 14526128)1, 4, 9 Bernardino A.L....Zatz M. (2003)
    19. SPINK1 mutations are associated with multiple phenotypes. (PubMed id 12120224)1, 4, 9 Pfutzer R.H. and Whitcomb D.C. (2001)
    20. Genetic mutations in a Spanish population with chroni c pancreatitis. (PubMed id 19657220)1, 4, 9 Mora J....FarrAc A. (2009)
    21. Mutations N34S and P55S of the SPINK1 gene in patients with chronic pancreatitis or pancreatic cancer and in healthy subjects: a report from Finland. (PubMed id 15764155)1, 4, 9 Lempinen M....Stenman U.H. (2005)
    22. Polymorphisms of SPINK1 N34S and CFTR in patients with sporadic and familial pancreatic cancer. (PubMed id 14688470)1, 4, 9 Matsubayashi H....Goggins M. (2003)
    23. The N34S mutation of SPINK1 (PSTI) is associated with a familial pattern of idiopathic chronic pancreatitis but does not cause the disease. (PubMed id 11950815)1, 4, 9 Threadgold J....Neoptolemos J.P. (2002)
    24. Gene mutations in children with chronic pancreatitis. (PubMed id 12120220)1, 4, 9 Witt H. (2001)
    25. Analysis of CFTR, SPINK1, PRSS1 and AAT mutations in children with acute or chronic pancreatitis. (PubMed id 16954950)1, 4, 9 Sobczynska-Tomaszewska A....Bal J. (2006)
    26. Lack of association between UGT1A7, UGT1A9, ARP, SPINK1 and CFTR gene polymorphisms and pancreatic cancer in Italian patients. (PubMed id 17072959)1, 4, 9 Piepoli A....Perri F. (2006)
    27. Complete cystic fibrosis transmembrane conductance regulator gene sequencing in patients with idiopathic chronic pancreatitis and controls. (PubMed id 15987793)1, 4, 9 Weiss F.U....Lerch M.M. (2005)
    28. Mutation analysis of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, the cationic trypsinogen (PRSS1) gene, and the serine protease inhibitor, Kazal type 1 (SPINK1) gene in patients with alcoholic chronic pancreatitis. (PubMed id 12939655)1, 4, 9 Perri F....Andriulli A. (2003)
    29. N34S, a pancreatitis associated SPINK1 mutation, is not associated with sporadic pancreatic cancer. (PubMed id 12649567)1, 4, 9 Teich N....Keim V. (2003)
    30. Association of SPINK1 gene mutation and CFTR gene pol ymorphisms in patients with pancreas divisum presenting with idiopathic pancrea titis. (PubMed id 19593166)1, 4, 9 Garg P.K....Shastri S.S. (2009)
    31. Divergent Roles of SPINK1 and PRSS2 Variants in Tropical Calcific Pancreatitis. (PubMed id 19077465)1, 4, 9 Sundaresan S....Drenth J.P. (2008)
    32. Mutation analysis of SPINK1 and CFTR gene in Korean patients with alcoholic chronic pancreatitis. (PubMed id 16187186)1, 4, 9 Lee K.H....Yoon Y.B. (2005)
    33. Pancreatic secretory trypsin inhibitor (SPINK1) gene mutations in patients with acute pancreatitis. (PubMed id 15782101)1, 4, 9 Tukiainen E....Puolakkainen P. (2005)
    34. Determination of the relative contribution of three genes-the cystic fibrosis transmembrane conductance regulator gene, the cationic trypsinogen gene, and the pancreatic secretory trypsin inhibitor gene-to the etiology of idiopathic chronic pancreatitis. (PubMed id 11938439)1, 4, 9 Audrezet M.P....Ferec C. (2002)
    35. Connections between genetics and clinical data: Role of MCP-1, CFTR, and SPINK-1 in the setting of acute, acute recurrent, and chron ic pancreatitis. (PubMed id 19844201)1, 4, 9 Cavestro G.M....Di Mario F. (2010)
    36. Investigation of the SPINK1 N34S mutation in Romanian patients with alcoholic chronic pancreatitis. A clinical analysis based on the criteria of the M-ANNHEIM classification. (PubMed id 19565042)1, 4, 9 Diaconu B.L....Schneider A. (2009)
    37. Tropical calcific pancreatitis and its association with CTRC and SPINK1 (p.N34S) variants. (PubMed id 19404200)1, 4, 9 Derikx M.H....Drenth J.P. (2009)
    38. Association and differential role of PRSS1 and SPINK1 mutation in early-onset and late-onset idiopathic chronic pancreatitis in Chinese subjects. (PubMed id 19433603)1, 4, 9 Chang Y.T....Chang M.C. (2009)
    39. SPINK1 N34S Is Strongly Associated With Recurrent Acu te Pancreatitis but Is Not a Risk Factor for the First or Sentinel Acute Pancre atitis Event. (PubMed id 19888199)1, 4, 9 Aoun E....Whitcomb D.C. (2009)
    40. Pathways to injury in chronic pancreatitis: decoding the role of the high-risk SPINK1 N34S haplotype using meta-analysis. (PubMed id 18414673)1, 4, 9 Aoun E....Whitcomb D.C. (2008)
    41. Clinical and radiological outcome of patients suffering from chronic pancreatitis associated with gene mutations. (PubMed id 18953248)1, 4, 9 Frulloni L....Vantini I. (2008)
    42. TCF7L2 gene polymorphisms do not predict susceptibility to diabetes in tropical calcific pancreatitis but may interact with SPINK1 and CTSB mutations in predicting diabetes. (PubMed id 18706099)1, 4, 9 Mahurkar S....Chandak G.R. (2008)
    43. The SPINK1 N34S variant is associated with acute pancreatitis. (PubMed id 18617776)1, 4, 9 O`reilly D.A....Kingsnorth A.N. (2008)
    44. Microsatellite scan identifies new candidate genes for susceptibility to alcoholic chronic pancreatitis in Japanese patients. (PubMed id 19096130)1, 4, 9 Kitahara K....Ota M. (2008)
    45. Association of cystic fibrosis transmembrane conductance regulator (CFTR) mutation/variant/haplotype and tumor necrosis factor (TNF) promoter polymorphism in hyperlipidemic pancreatitis. (PubMed id 17981921)1, 4, 9 Chang Y.T....Wong J.M. (2008)
    46. Comprehensive screening for reg1alpha gene rules out association with tropical calcific pancreatitis. (PubMed id 17990360)1, 4, 9 Mahurkar S....Chandak G.R. (2007)
    47. Lack of significant association of an insertion/deletion polymorphism in the angiotensin converting enzyme (ACE) gene with tropical calcific pancreatitis. (PubMed id 17163998)1, 4, 9 Bhaskar S....Chandak G.R. (2006)
    48. Association of rare SPINK1 gene mutation with another base substitution in chronic pancreatitis patients. (PubMed id 16981266)1, 4, 9 Kalinin V.N....Yekebas E.F. (2006)
    49. The SPINK1 N34S mutation is not associated with Type 2 diabetes mellitus in a population of the USA. (PubMed id 15910626)1, 4, 9 Schneider A....Whitcomb D.C. (2005)
    50. Limited contribution of the SPINK1 N34S mutation to the risk and severity of alcoholic chronic pancreatitis: a report from the United States. (PubMed id 12822871)1, 4, 9 Schneider A....Whitcomb D.C. (2003)
    51. Germline mutations in CFTR and PSTI genes in chronic pancreatitis patients. (PubMed id 12452372)1, 4, 9 Gaia E....Carlo A. (2002)
    52. Tropical calcific pancreatitis: strong association with SPINK1 trypsin inhibitor mutations. (PubMed id 12360463)1, 4, 9 Bhatia E....Witt H. (2002)
    53. SPINK1/PSTI mutations are associated with tropical pancreatitis and type II diabetes mellitus in Bangladesh. (PubMed id 12360464)1, 4, 9 Schneider A....Whitcomb D.C. (2002)
    54. Mutations of the serine protease inhibitor, Kazal type 1 gene, in patients with idiopathic chronic pancreatitis. (PubMed id 12014716)1, 4, 9 Truninger K....Becker M. (2002)
    55. Mutations in the pancreatic secretory trypsin inhibitor gene (PSTI/SPINK1) rather than the cationic trypsinogen gene (PRSS1) are significantly associated with tropical calcific pancreatitis. (PubMed id 12011155)1, 2, 9 Chandak G.R....Singh L. (2002)
    56. Combined Bicarbonate Conductance-Impairing Variants i n CFTR and SPINK1 Variants Are Associated With Chronic Pancreatitis in Patients Without Cystic Fibrosis. (PubMed id 20977904)1, 4 Schneider A....Whitcomb D.C. (2011)
    57. Genetic, epidemiological, and clinical aspects of her editary pancreatitis: a population-based cohort study in Denmark. (PubMed id 20502448)1, 4 Joergensen M.T....Schaffalitzky de Muckadell O.B. (2010)
    58. Idiopathic chronic pancreatitis in India: phenotypic characterisation and strong genetic susceptibility due to SPINK1 and CFTR gene mutations. (PubMed id 20551465)1, 4 Midha S....Garg P.K. (2010)
    59. Incidence, prevalence, etiology, and prognosis of fir st-time chronic pancreatitis in young patients: a nationwide cohort study. (PubMed id 20108119)1, 4 Joergensen M....de Muckadell O.B. (2010)
    60. Association of genetic variants with chronic kidney d isease in individuals with different lipid profiles. (PubMed id 19578796)1, 4 Yoshida T....Yamada Y. (2009)
    61. Fine mapping of the CELIAC2 locus on chromosome 5q31- q33 in the Finnish and Hungarian populations. (PubMed id 19845895)1, 4 Koskinen L.L....Saavalainen P. (2009)
    62. Association Analyses of Genetic Polymorphisms of GSTM1, GSTT1, NQO1, NAT2, LPL, PRSS1, PSTI, and CFTR With Chronic Alcoholic Pancreatitis in Japan. (PubMed id 18986377)1, 4 Maruyama K....Otsuki M. (2008)
    63. Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population: role of serine protease inhibitor Kazal 1type and alcohol. (PubMed id 18680227)1, 4 Muddana V....Whitcomb D.C. (2008)
    64. The SPINK gene family and celiac disease susceptibility. (PubMed id 17333166)1, 4 Wapenaar M.C....Wijmenga C. (2007)
    65. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    66. Mutational screening of patients with nonalcoholic chronic pancreatitis: identification of further trypsinogen variants. (PubMed id 11866271)1, 4 Teich N.... Keim V. (2002)
    67. Mutational analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene in hereditary and sporadic chronic pancreatitis. (PubMed id 10691414)1, 2 Chen J.-M.... Ferec C. (2000)
    68. Solution structure of a variant of human pancreatic secretory trypsin inhibitor determined by nuclear magnetic resonance spectroscopy. (PubMed id 8433367)1, 2 Klaus W. and Schomburg D. (1993)
    69. Three-dimensional structure of a recombinant variant of human pancreatic secretory trypsin inhibitor (Kazal type). (PubMed id 1613792)1, 2 Hecht H.-J.... Schomburg D. (1992)
    70. Primary structure of human pancreatic secretory trypsin inhibitor (PSTI) gene. (PubMed id 3501289)1, 2 Horii A.... Matsubara K. (1987)
    71. Expression of pancreatic secretory trypsin inhibitor gene in neoplastic tissues. (PubMed id 2961612)1, 2 Tomita N.... Matsubara K. (1987)
    72. Molecular cloning and nucleotide sequence of human pancreatic secretory trypsin inhibitor (PSTI) cDNA. (PubMed id 3877508)1, 2 Yamamoto T....Matsubara K. (1985)
    73. Purification and characterization of a tumor-associated trypsin inhibitor from the urine of a patient with ovarian cancer. (PubMed id 7142173)1, 2 Huhtala M.-L.... Stenman U.-H. (1982)
    74. The primary structure of the human pancreatic secretory trypsin inhibitor. Amino acid sequence of the reduced S-aminoethylated protein. (PubMed id 843082)1, 2 Bartelt D.C.... Greene L.J. (1977)
    75. Co-expression of trypsin and tumour-associated trypsin inhibitor (TATI) in colorectal adenocarcinomas. (PubMed id 12973686)1, 9 Solakidi S....Sekeris C.E. (2003)
    76. Differential expression of trypsinogen and tumor-associated trypsin inhibitor (TATI) in bladder cancer. (PubMed id 16327984)1, 9 Hotakainen K....Stenman U.H. (2006)
    77. Minigene analysis of intronic variants in common SPINK1 haplotypes associated with chronic pancreatitis. (PubMed id 18978175)1, 9 Kereszturi E....Sahin-TA^th M. (2009)
    78. Tumour-associated trypsin inhibitor, carcinoembryonic antigen and acute-phase reactant proteins CRP and alpha1-antitrypsin in patients with gastrointestinal malignancies. (PubMed id 14675563)1, 9 Solakidi S....Sekeris C.E. (2004)
    79. Association of SPINK1 expression and TMPRSS2:ERG fusi on with prognosis in endocrine-treated prostate cancer. (PubMed id 20442300)1, 9 Leinonen K.A....Visakorpi T. (2010)
    80. The role of SPINK1 in ETS rearrangement-negative prostate cancers. (PubMed id 18538735)1, 9 Tomlins S.A....Chinnaiyan A.M. (2008)
    81. N34S mutation in the SPINK1 gene is not associated with alternative splicing. (PubMed id 17446841)1, 9 Masamune A....Shimosegawa T. (2007)
    82. Detection of a large genomic deletion in the pancreatic secretory trypsin inhibitor (SPINK1) gene. (PubMed id 16823394)1, 9 Masson E....Ferec C. (2006)
    83. Hereditary pancreatitis as the premalignant disease: a Japanese case of pancreatic cancer involving the SPINK1 gene mutation N34S. (PubMed id 15084977)4, 9 Masamune A....Shimosegawa T. (2004)
    84. Identification of genes up-regulated in urothelial tumors: the 67-kd laminin receptor and tumor-associated trypsin inhibitor. (PubMed id 12875970)1, 9 Diggle C.P....Harnden P. (2003)
    85. Analysis of PRSS1 and SPINK1 mutations in Korean patients with idiopathic and familial pancreatitis. (PubMed id 18852684)1, 9 Oh H.C....Kim G.H. (2009)
    86. Missense mutations in pancreatic secretory trypsin inhibitor (SPINK1) cause intracellular retention and degradation. (PubMed id 17525091)1, 9 Kiraly O....Sahin-Toth M. (2007)
    87. Co-inheritance of a novel deletion of the entire SPINK1 gene with a CFTR missense mutation (L997F) in a family with chronic pancreatitis. (PubMed id 17681820)1, 9 Masson E....Ferec C. (2007)
    88. High tissue expression of tumour-associated trypsin inhibitor (TATI) associates with a more favourable prognosis in gastric cancer. (PubMed id 15810949)1, 9 Wiksten J.P....Haglund C. (2005)
    89. High expression of tumour-associated trypsin inhibitor correlates with liver metastasis and poor prognosis in colorectal cancer. (PubMed id 19384300)1, 9 Gaber A....Birgisson H. (2009)
    90. Urinary matrix metalloproteinase -8, -9, -14 and their regulators (TRY-1, TRY-2, TATI) in patients with diabetic nephropathy. (PubMed id 18428024)1, 9 Lauhio A....Honkanen E. (2008)
    91. Autocrine induction of invasion and metastasis by tumor-associated trypsin inhibitor in human colon cancer cells. (PubMed id 18317448)1, 9 Gouyer V....Huet G. (2008)
    92. Novel mutations in the calcium sensing receptor gene in tropical chronic pancreatitis in India. (PubMed id 18938753)4, 9 Murugaian E.E....Vallath B. (2008)
    93. Screening for human cationic trypsinogen (PRSS1) and trypsinogen inhibitor gene (SPINK1) mutations in a Finnish family with hereditary pancreatitis. (PubMed id 17613931)1, 9 Raty S....Herzig K.H. (2007)
    94. Cationic trypsinogen and pancreatic secretory trypsin inhibitor gene mutations in neonatal hypertrypsinaemia. (PubMed id 12529713)1, 9 Patuzzo C....Pignatti P.F. (2003)
    95. SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis. (PubMed id 10982753)1, 9 Pfutzer R.H....Whitcomb D.C. (2000)
    96. Mutations in the calcium-sensing receptor: a new genetic risk factor for chronic pancreatitis? (PubMed id 16497624)1, 9 Felderbauer P....Schmidt W.E. (2006)
    97. A novel SPINK1 gene mutation, c.206C>T, in a Thai patient with chronic alcoholic pancreatitis. (PubMed id 18182741)1, 9 Rerknimitr R....Snabboon T. (2008)
    98. Characterization of ETS gene aberrations in select hi stologic variants of prostate carcinoma. (PubMed id 19465903)1, 9 Han B....Shah R.B. (2009)
    99. Serine protease inhibitor kazal type 1 mutations and pancreatitis. (PubMed id 15749232)1, 9 Schneider A. (2005)
    100. Chronic parotitis: not another SPINKosis. (PubMed id 15753612)1, 9 Gundling F....Teich N. (2004)
    101. Acute pancreatitis in the early stages of pregnancy associated with a PSTI gene mutation. (PubMed id 15367892)1, 9 Inoue N....Funakoshi A. (2004)
    102. Human mesotrypsin is a unique digestive protease specialized for the degradation of trypsin inhibitors. (PubMed id 14507909)1, 9 Szmola R....Sahin-Toth M. (2003)
    103. Analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene mutations in Japanese patients with chronic pancreatitis. (PubMed id 11355022)1, 9 Kaneko K....Horii A. (2001)
    104. CFTR, SPINK1, CTRC and PRSS1 variants in chronic pancr eatitis: is the role of mutated CFTR overestimated? (PubMed id 22427236)1 Rosendahl J....Witt H. (2013)
    105. Molecular dynamics simulations reveal structural insta bility of human trypsin inhibitor upon D50E and Y54H mutations. (PubMed id 22955423)1 Mokmak W....Tongsima S. (2013)
    106. Global gene expression profiling reveals SPINK1 as a p otential hepatocellular carcinoma marker. (PubMed id 23527199)1 Marshall A....Odom D.T. (2013)
    107. The contribution of the SPINK1 c.194+2T>C mutation to the clinical course of idiopathic chronic pancreatitis in Chinese patients. (PubMed id 23017645)1 Sun C....Li Z. (2013)
    108. Screening of R122H and N29I mutations in the PRSS1 gen e and N34S mutation in the SPINK1 gene in Mexican pediatric patients with acute and recurrent pancreatitis. (PubMed id 22699143)1 Sanchez-Ramirez C.A....Sanchez-Corona J. (2012)
    109. Is the SPINK1 variant p.N34S overrepresented in patien ts with acute pancreatitis? (PubMed id 22228370)1 Joergensen M.T....de Muckadell O.B. (2012)
    110. Tumour-associated trypsin inhibitor TATI is a prognost ic marker in colorectal cancer. (PubMed id 22508321)1 Koskensalo S....Haglund C. (2012)
    111. Genetic prevalence and characteristics in children wit h recurrent pancreatitis. (PubMed id 22094894)1 Sultan M....Venkatasubramani N. (2012)
    112. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    113. The N34S mutation of the SPINK1 gene and alcoholic chr onic pancreatitis. (PubMed id 22751291)1 Cichoz-Lach H....Korolczuk A. (2012)
    114. Functional analysis of eight missense mutations in the SPINK1 gene. (PubMed id 22343981)1 Boulling A....Ferec C. (2012)
    115. Phase II study of cytarabine in men with docetaxel-ref ractory, castration-resistant prostate cancer with evaluation of TMPRSS2-ERG and SPINK1 as serum biomarkers. (PubMed id 22313860)1 Dhani N.C....Joshua A.M. (2012)
    116. Creatinine clearance, cystatin C, beta2-microglobulin and TATI as markers of renal function in patients with proteinuria. (PubMed id 22307441)1 Tramonti G....Barsotti G. (2012)
    117. Association of tumor-associated trypsin inhibitor (TAT I) expression with molecular markers, pathologic features and clinical outcomes of urothelial carcinoma of the urinary bladder. (PubMed id 21739120)1 Patschan O....Bjartell A. (2012)
    118. Do genetic variants in the SPINK1 gene affect the leve l of serum PSTI? (PubMed id 22526274)1 Kume K....Shimosegawa T. (2012)
    119. Genetic basis of chronic pancreatitis in Asia Pacific region. (PubMed id 21323990)1 Reddy D.N. and Prasad S.S. (2011)
    120. High incidence of PRSS1 and SPINK1 mutations in Korea n children with acute recurrent and chronic pancreatitis. (PubMed id 21415673)1 Lee Y.J....Yoo H.W. (2011)
    121. Therapeutic targeting of SPINK1-positive prostate can cer. (PubMed id 21368222)1 Ateeq B....Chinnaiyan A.M. (2011)
    122. Combined genomic and phenotype screening reveals secr etory factor SPINK1 as an invasion and survival factor associated with patient prognosis in breast cancer. (PubMed id 21656687)1 Soon W.W....Liu E.T. (2011)
    123. Assessing the pathological relevance of SPINK1 promot er variants. (PubMed id 21610753)1 Boulling A....FAcrec C. (2011)
    124. [Pancreatic secretory trypsin inhibitor gene N34S muta tion in patients with idiopathic chronic pancreatitis]. (PubMed id 22363992)1 Kucheriavyi I.u.A....Maev I.V. (2011)
    125. ABO blood group and chronic pancreatitis risk in the N APS2 cohort. (PubMed id 21792085)1 Greer J.B....Whitcomb D.C. (2011)
    126. Effects of radiation therapy on tissue and serum conce ntrations of tumour associated trypsin inhibitor and their prognostic significan ce in rectal cancer patients. (PubMed id 21864386)1 Gaber A....Jirstrom K. (2011)
    127. Presence of SPINK-1 variant alters the course of chro nic pancreatitis. (PubMed id 21375584)1 Sandhu B....Sanyal A. (2011)
    128. Interaction between a novel intronic IVS3+172 variant and N29I mutation in PRSS1 gene is associated with pancreatitis in a Malaysian Chinese family. (PubMed id 21952138)1 Chua K.H....Goh K.L. (2011)
    129. Roles of serine protease inhibitor Kazal type 1 (SPINK 1) in pancreatic diseases. (PubMed id 22041280)1 Ohmuraya M. and Yamamura K. (2011)
    130. Phenotypic variability of the homozygous IVS3+2T>C mutation in the serine protease inhibitor Kazal type 1 (SPINK1) gene in patien ts with chronic pancreatitis. (PubMed id 20543535)1 Ota Y....Kikuyama M. (2010)
    131. Hepatitis B and hepatitis C virus replication upregul ates serine protease inhibitor Kazal, resulting in cellular resistance to serin e protease-dependent apoptosis. (PubMed id 19864383)1 Lamontagne J....Lu X. (2010)
    132. The Prevalence of Cationic Trypsinogen (PRSS1) and Se rine Protease Inhibitor, Kazal Type 1 (SPINK1) Gene Mutations in Polish Patient s with Alcoholic and Idiopathic Chronic Pancreatitis. (PubMed id 20676769)1 Gasiorowska A....Malecka-Panas E. (2010)
    133. Multifactorial Genesis of Pancreatitis in Primary Hyp erparathyroidism: Evidence for 'Protective' (PRSS2) and 'Destruc tive' (CTRC) Genetic Factors. (PubMed id 20625975)1 Felderbauer P....Bulut K. (2010)
    134. Increased serum levels of tumour-associated trypsin i nhibitor independently predict a poor prognosis in colorectal cancer patients. (PubMed id 20849596)1 Gaber A....JirstrAPm K. (2010)
    135. Upstream open reading frames cause widespread reducti on of protein expression and are polymorphic among humans. (PubMed id 19372376)1 Calvo S.E....Mootha V.K. (2009)
    136. [Pancreatitis-associated genes and development of pan creatic cancer] (PubMed id 19654461)1 Masamune A....Shimosegawa T. (2009)
    137. Genotype-phenotype correlation in 9 patients with tro pical pancreatitis and identified gene mutations. (PubMed id 19696993)1 Rajesh G....Balakrishnan V. (2009)
    138. Pancreatic secretory trypsin inhibitor is a major mot ogenic and protective factor in human breast milk. (PubMed id 19147803)1 Marchbank T....Playford R.J. (2009)
    139. Tumor-associated protein SPIK/TATI suppresses serine protease dependent cell apoptosis. (PubMed id 18347987)1 Lu X....Block T.M. (2008)
    140. Copy number variations in chronic pancreatitis. (PubMed id 19287144)1 Chen J.M....FAcrec C. (2008)
    141. Functional analysis of pancreatitis-associated missense mutations in the pancreatic secretory trypsin inhibitor (SPINK1) gene. (PubMed id 17568390)1 Boulling A....Ferec C. (2007)
    142. Genetic issues in pediatric pancreatitis. (PubMed id 16764792)1 Kandula L....Lowe M.E. (2006)
    143. The impact of cystic fibrosis and PSTI/SPINK1 gene mutations on susceptibility to chronic pancreatitis. (PubMed id 15749233)1 Cohn J.A....Jowell P.S. (2005)
    144. Absence of association between SPINK1 trypsin inhibitor mutations and Type 1 or 2 diabetes mellitus in India and Germany. (PubMed id 14595541)1 Bhatia E....Lerch M.M. (2003)
    145. Gene symbol: Spink1-Omim 167790. Disease: hereditary pancreatitis. (PubMed id 12974284)2 Deybach J.-C.D.... Ruszniewski P. (2003)
    146. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    147. Human pancreatic secretory trypsin inhibitor. Distribution, actions and possible role in mucosal integrity and repair. (PubMed id 9643675)1 Marchbank T....Playford R.J. (1998)
    148. PRSS1-Related Hereditary Pancr eatitis (PubMed id 22379635)1 Solomon S....LaRusch J. (1993)
    149. Three-dimensional structure of the complexes between bovine chymotrypsinogen A and two recombinant variants of human pancreatic secretory trypsin inhibitor (Kazal-type). (PubMed id 1870127)1 Hecht H.J....Schomburg D. (1991)
    150. A low-molecular-mass Kazal-type protease inhibitor isolated from rat hepatocytes is identical to rat pancreatic secretory trypsin inhibitor II. Purification and amino acid sequence. (PubMed id 2110056)1 Kido H....Katunuma N. (1990)
    151. Interactions of pancreatic secretory trypsin inhibitor in small intestinal juice: its hydrolysis and protection by intraluminal factors. (PubMed id 2093478)1 Freeman T.C....Calam J. (1990)
    152. Increased expression of tumor-associated trypsin inhibitor, TATI, in prostate cancer and in androgen-independent 22Rv1 cells. (PubMed id 17306443)9 Paju A....Bjartell A. (2007)
    153. Tumor-associated trypsin inhibitor in normal and malignant renal tissue and in serum of renal-cell carcinoma patients. (PubMed id 10508484)9 Lukkonen A....Stenman U.H. (1999)
    154. Urinary levels of tumor-associated trypsin inhibitor (TATI) in the detection of transitional cell carcinoma of the urinary bladder. (PubMed id 15963628)9 Shariat S.F....Stenman U.H. (2005)
    155. Effect of intracavitary radiotherapy on tumor-associated trypsin inhibitor (TATI) in patients with cervical and endometrial cancer. (PubMed id 2354815)9 Lehtovirta P....Stenman U.H. (1990)
    156. Serine protease inhibitor Kazal type 1 promotes proli feration of pancreatic cancer cells through the epidermal growth factor recepto r. (PubMed id 19737965)9 Ozaki N....Yamamura K. (2009)
    157. Assessment of tumor-associated trypsin inhibitor (TATI) as a marker of renal function. (PubMed id 14733412)9 Tramonti G....Bianchi C. (2003)
    158. TPA, TATI, CEA, AFP, beta-HCG, PSA, SCC, and CA 19-9 for monitoring transitional cell carcinoma of the bladder. (PubMed id 8638540)9 Pectasides D....Athanassiou A. (1996)
    159. Specific expression of the pancreatic-secretory-trypsin-inhibitor (PSTI) gene in hepatocellular carcinoma. (PubMed id 8244568)9 Ohmachi Y....Matsubara K. (1993)
    160. Expression of trypsinogen-1, trypsinogen-2, and tumor-associated trypsin inhibitor in ovarian cancer: prognostic study on tissue and serum. (PubMed id 15269150)9 Paju A....Stenman U.H. (2004)
    161. Tumor-associated trypsin inhibitor (TATI) and renal function. (PubMed id 9453997)9 Tramonti G....Bianchi C. (1997)
    162. Tumor-associated trypsin inhibitor (TATI) in primary esophageal carcinoma. (PubMed id 1780688)9 Gion M....Bruscagnin G. (1991)
    163. Comparison of tumor-associated trypsin inhibitor (TATI) with CA125 as a marker for diagnosis and monitoring of epithelial ovarian cancer. (PubMed id 1780685)9 Gadducci A....Fioretti P. (1991)
    164. Overexpression of tumour-associated trypsin inhibitor (TATI) enhances tumour growth and is associated with portal vein invasion, early recurrence and a stage-independent prognostic factor of hepatocellular carcinoma. (PubMed id 17267202)9 Lee Y.C....Hsu H.C. (2007)
    165. A novel mutation of the calcium sensing receptor gene is associated with chronic pancreatitis in a family with heterozygous SPINK1 mutations. (PubMed id 14641934)9 Felderbauer P....Schmidt W.E. (2003)
    166. TATI (tumor associated trypsin inhibitor) and cancer antigen 125 (CA 125) in patients with early-stage endometrial cancer. (PubMed id 9891532)9 Peters-Engl C....Medl M. (1998)
    167. Tumour-associated trypsin inhibitor and renal cell carcinoma. (PubMed id 7601186)9 Meria P....Le Duc A. (1995)
    168. Tumour-associated trypsin inhibitor (TATI) in patients with colorectal cancer: a comparison with CEA, CA 50 and CA 242. (PubMed id 7667604)9 Pasanen P....Alhava E. (1995)
    169. Biology and function of tumor-associated trypsin inhibitor, TATI. (PubMed id 1780691)9 Stenman U.H....Itkonen O. (1991)
    170. Concentration of tumor-associated trypsin inhibitor (TATI) in pleural effusions. (PubMed id 2225961)9 Klockars M....Stenman U.H. (1990)
    171. Tumour-associated trypsin inhibitor (TATI): comparison with CA125 as a preoperative prognostic indicator in advanced ovarian cancer. (PubMed id 7981075)9 Venesmaa P....Ylikorkala O. (1994)
    172. Evaluation of urine tumor-associated trypsin inhibitor, CYFRA 21-1, and urinary bladder cancer antigen for detection of high-grade bladder carcinoma. (PubMed id 18514770)9 Gkialas I....Lykourinas M. (2008)
    173. Functional analysis of recombinant pancreatic secretory trypsin inhibitor protein with amino-acid substitution. (PubMed id 12483248)9 Kuwata K....Ogawa M. (2002)
    174. Serum levels of tumor associated trypsin inhibitor (TATI) and glomerular filtration rate. (PubMed id 9574455)9 Tramonti G....Bianchi C. (1998)
    175. Serum levels of the tumour-associated trypsin inhibitor in patients with endometriosis. (PubMed id 8988701)9 Medl M....Leodolter S. (1997)
    176. Serum tumour-associated trypsin inhibitor (TATI) and renal function. (PubMed id 8981662)9 Tramonti G....Bianchi C. (1996)
    177. Tumor-associated trypsin inhibitor (TATI) and cancer antigen 125 (CA125) in patients with epithelial ovarian cancer. (PubMed id 8669854)9 Peters-Engl C....Leodolter S. (1995)
    178. TATI (tumour-associated trypsin inhibitor) as a marker of ovarian cancer. (PubMed id 7734298)9 Medl M....Leodolter S. (1995)
    179. Tumour-associated trypsin inhibitor in the diagnosis of pancreatic carcinoma. (PubMed id 8207049)9 Pasanen P.A....Alhava E. (1994)
    180. Transgenic expression of pancreatic secretory trypsin inhibitor-1 rescues SPINK3-deficient mice and restores a normal pancreatic phe notype. (PubMed id 20110462)9 Romac J.M....Liddle R.A. (2010)
    181. Signal peptide variants that impair secretion of pancreatic secretory trypsin inhibitor (SPINK1) cause autosomal dominant hereditary pancreatitis. (PubMed id 17274009)9 Kiraly O....Ferec C. (2007)
    182. Serine protease inhibitor Kazal type 1 mutations and pancreatitis. (PubMed id 15528018)9 Schneider A. (2004)
    183. Trypsinogen-1, -2 and tumour-associated trypsin-inhibitor in bile and biliary tract tissues from patients with biliary tract diseases and pancreatic carcinomas. (PubMed id 11347977)9 Hedstrom J....Stenman U.H. (2001)
    184. Binding of bovine basic pancreatic trypsin inhibitor (Kunitz) as well as bovine and porcine pancreatic secretory trypsin inhibitor (Kazal) to human cathepsin G: a kinetic and thermodynamic study. (PubMed id 7510795)9 Fioretti E....Ascoli F. (1993)
    185. Tumor-associated trypsin inhibitor (TATI) in bone diseases. (PubMed id 1780696)9 Rapellino M....Libertucci D. (1991)
    186. Tumor-associated trypsin inhibitor (TATI) in the diagnosis of lung cancer. (PubMed id 1780695)9 Pecchio F....Coni F. (1991)
    187. Tumor-associated trypsin inhibitor in induced and acquired immunodeficiency. Studies on transplanted and HIV-infected patients. (PubMed id 1780693)9 Banfi G....Bonini P.A. (1991)
    188. Tumour-associated trypsin inhibitor (TATI) and cancer antigen 125 (CA 125) in mucinous ovarian tumours. (PubMed id 2310684)9 Mogensen O....Jakobsen A. (1990)
    189. Tumor-associated trypsin inhibitor and cancer antigen 125 in pelvic masses. (PubMed id 2167279)9 Mogensen O....Jakobsen A. (1990)
    190. Mitochondrial DNA A3243G mutation involved in familial diabetes, chronic intestinal pseudo-obstruction and recurrent pancreatitis. (PubMed id 18955007)9 Verny C....Bonneau D. (2008)
    191. A 93 year old man with the PRSS1 R122H mutation, low SPINK1 expression, and no pancreatitis: insights into phenotypic non-penetrance. (PubMed id 16354799)9 Khalid A....Whitcomb D.C. (2006)
    192. Mutational analysis of the pancreatic secretory trypsin inhibitor gene in familial and juvenile pancreatitis in Japan. (PubMed id 12743777)9 Kuwata K....Ogawa M. (2003)
    193. Motion--genetic testing is useful in the diagnosis of nonhereditary pancreatic conditions: arguments against the motion. (PubMed id 12560856)9 Cohn J.A. (2003)
    194. The course of genetically determined chronic pancreatitis. (PubMed id 12853682)9 Keim V....Mossner J. (2003)
    195. Fluoride metabolism in smokers and non-smokers follow ing enflurane anaesthesia. (PubMed id 14633748)9 Laisalmi M....Lindgren L. (2003)
    196. Idiopathic pancreatitis related to CFTR: complex inheritance and identification of a modifier gene. (PubMed id 12227654)9 Cohn J.A....Jowell P.S. (2002)
    197. Genetic mutations in exons 3 and 4 of the pancreatic secretory trypsin inhibitor in patients with pancreatitis. (PubMed id 11578065)9 Kuwata K....Ogawa M. (2001)
    198. SPINK1/PSTI mutations are associated with tropical pancreatitis in Bangladesh. A preliminary report. (PubMed id 12120202)9 Rossi L....Whitcomb D.C. (2001)
    199. Evaluation of TATI and CYFRA 21-1 in patients with head and neck squamous cell carcinoma. (PubMed id 9166881)9 Goumas P.D....Nikiforidis G.C. (1997)
    200. Serum tumor markers CEA, CA 50, TATI, and NSE in lung cancer screening. (PubMed id 8443749)9 Jarvisalo J....Aromaa A. (1993)
    201. Squamous cell carcinoma antigen (SCC), carcinoembryonic antigen (CEA), and tumour-associated trypsin inhibitor (TATI) for monitoring head and neck cancer. (PubMed id 8366300)9 Pectasides D....Athanassiou A. (1993)
    202. Cancer-associated antigen CA 195 in patients with mucinous ovarian tumours: a comparative analysis with CEA, TATI and CA 125 in serum specimens and cyst fluids. (PubMed id 8392219)9 de Bruijn H.W....Aalders J.G. (1993)
    203. The concomitant determination of different serum tumor markers in epithelial ovarian cancer: relevance for monitoring the response to chemotherapy and follow-up of patients. (PubMed id 1544592)9 Fioretti P....Bianchi R. (1992)
    204. [Effects of pH on the formation and dissociation of t he complex of trypsin and PSTI] (PubMed id 1377760)9 Seshimo T....Nakase A. (1992)
    205. Binding of the bovine and porcine pancreatic secretor y trypsin inhibitor (Kazal) to human leukocyte elastase: a thermodynamic study. (PubMed id 1669448)9 Ascenzi P....Menegatti E. (1991)
    206. Tumor-associated trypsin inhibitor (TATI) in patients with colorectal carcinoma. A critical comparison with CEA. (PubMed id 1780689)9 Catarino M. and Conde R. (1991)
    207. Tumor-associated trypsin inhibitor (TATI) in benign and malignant gastric disease. (PubMed id 1780694)9 Loizate Toricaguena A....Legorburu Escudero J.F. (1991)
    208. Evaluation of TATI and other markers in solid tumors. (PubMed id 1780686)9 Taccone W....Belli M. (1991)
    209. Tumor-associated trypsin inhibitor, TATI, in gastrointestinal cancer and related benign diseases. (PubMed id 1780697)9 Piantino P. and Arosaio E. (1991)
    210. Tumor-associated trypsin inhibitor (TATI) in pleural effusions. (PubMed id 1780690)9 Rapellino M....Ricardi G. (1991)
    211. Tumor markers CA 125, carcinoembryonic antigen and tumor-associated trypsin inhibitor in patients with cervical adenocarcinoma. (PubMed id 2258083)9 Leminen A. (1990)
    212. Expression of pancreatic secretory trypsin inhibitor gene in human colorectal tumor. (PubMed id 2224769)9 Tomita N....Yokouchi H. (1990)
    213. A comparison of the usefulness of serum measurements of CA 125, CA 50 and TATI in patients with malignant and benign gynecological pathology. (PubMed id 2379509)9 Gadducci A....Fioretti P. (1990)
    214. Tumor-associated trypsin inhibitor as a prognostic factor during follow-up of bladder cancer. (PubMed id 12893328)9 Kelloniemi E....Stenman U.H. (2003)
    215. Pre-operative serum level of tumour-associated trypsin inhibitor and residual tumour size as prognostic indicators in Stage III epithelial ovarian cancer. (PubMed id 9637119)9 Venesmaa P....Paavonen J. (1998)
    216. Hereditary pancreatitis in children: surgical implica tions with special regard to genetic background. (PubMed id 19944211)9 Schmitt F....Podevin G. (2009)
    217. Comparison of secondary and primary ovarian malignancies reveals differences in their pre- and perioperative characteristics. (PubMed id 16278010)9 Antila R....Heikinheimo O. (2006)
    218. Biochemical models of hereditary pancreatitis. (PubMed id 16632094)9 Sahin-Toth M. (2006)
    219. Reduced CFTR function and the pathobiology of idiopathic pancreatitis. (PubMed id 15758663)9 Cohn J.A. (2005)
    220. [Chronic pancreatitis--pancreas cancer: influence of genetic factors] (PubMed id 15957615)9 Keim V. (2005)
    221. Association of trypsin-2 with activation of gelatinase B and collagenase-2 in human bronchoalveolar lavage fluid in vivo. (PubMed id 11585105)9 Prikk K....Sorsa T. (2001)
    222. Preoperative serum concentration of hCGbeta as a prognostic factor in ovarian cancer. (PubMed id 11494231)9 Vartiainen J....Alfthan H. (2001)
    223. Genetic aspects of chronic pancreatitis: insights into aetiopathogenesis and clinical implications. (PubMed id 11775491)9 Truninger K....Witt H. (2001)
    224. Squamous cell carcinoma antigen, tumor-associated trypsin inhibitor, and carcinoembryonic antigen for monitoring cervical cancer. (PubMed id 8048392)9 Pectasides D....Athanassiou A. (1994)
    225. [Tissue polypeptide antigen and tumor trypsin inhibitor in pleural effusions of various etiologies] (PubMed id 1481445)9 Plavec G....NinkoviA8 M. (1992)
    226. Evaluation of tumor-associated trypsin inhibitor (TATI) in women with benign and malignant gynecological disease. (PubMed id 1780683)9 Inaudi P....D'Antona N. (1991)
    227. Evaluation of CEA, CA 19-9, CA-50, CA-195, and TATI with special reference to pancreatic disorders. (PubMed id 1791319)9 Masson P....Andren-Sandberg A. (1991)
    228. Response to IL-6 stimulation of human hepatoblastoma cells: production of pancreatic secretory trypsin inhibitor. (PubMed id 2119190)9 Yasuda T....Mori T. (1990)
    229. A comparative evaluation of the ability of serum CA 125, CA 19-9, CA 15-3, CA 50, CA 72-4 and TATI assays in reflecting the course of disease in patients with ovarian carcinoma. (PubMed id 2379512)9 Gadducci A....Fioretti P. (1990)
    230. Genetic aspects of pancreatitis. (PubMed id 20059346)9 Whitcomb D.C. (2010)
    231. The variable phenotype of the p.A16V mutation of cati onic trypsinogen (PRSS1) in pancreatitis families. (PubMed id 19951905)9 Grocock C.J....Greenhalf W. (2010)
    232. Recurrent acute pancreatitis caused by association of a novel mutation of the calcium-sensing receptor gene and a heterozygous mutat ion of the SPINK1 gene. (PubMed id 20335783)9 Baudry C....Levy P. (2010)
    233. Alcohol-induced acute pancreatitis: the 'critical mas s' concept. (PubMed id 20181433)9 Barreto S.G. and Saccone G.T. (2010)
    234. Biomarkers in prostate cancer diagnosis and prognosis: beyond prostate-specific antigen. (PubMed id 19325493)9 Fradet Y. (2009)
    235. Chronic hereditary pancreatitis in a girl with a serine protease inhibitor kazal type I (SPINK-1) gene mutation and a coxsackie type B5 infection. (PubMed id 19106771)9 Groeneweg M....Nieuwenhuis E.E. (2009)
    236. Chronic pancreatitis: genetics and pathogenesis. (PubMed id 19453252)9 Chen J.M. and FAcrec C. (2009)
    237. Integration of ERG gene mapping and gene-expression profiling identifies distinct categories of human prostate cancer. (PubMed id 19040532)9 Jhavar S....Cooper C.S. (2009)
    238. Genetic aspects of tropical calcific pancreatitis. (PubMed id 18604651)9 Witt H. and Bhatia E. (2008)
    239. Hereditary chronic pancreatitis. (PubMed id 18206817)9 Teich N. and Mossner J. (2008)
    240. Individual susceptibility to alcoholic pancreatitis. (PubMed id 18336667)9 Apte M.V....Wilson J.S. (2008)
    241. Alcoholic pancreatitis: new pathogenetic insights. (PubMed id 18663346)9 Lucrezio L....Gullo L. (2008)
    242. A first-generation multiplex biomarker analysis of urine for the early detection of prostate cancer. (PubMed id 18245462)9 Laxman B....Chinnaiyan A.M. (2008)
    243. [Toxicogenetics of antiretroviral treatment (II): neurotoxicity, hepatotoxicity, lactic acidosis, kidney damage, and other adverse effects of antiretroviral drugs.] (PubMed id 18680693)9 SA!nchez HellA-n V. and GutiAcrrez Rodero F. (2008)
    244. Concomitant autoimmune and genetic pancreatitis leads to severe inflammatory conditions. (PubMed id 18442214)9 Frossard J.L....Hadengue A. (2008)
    245. Comparison of the prognostic value of a panel of tissue tumor markers and established clinicopathological factors in patients with gastric cancer. (PubMed id 18751407)9 Wiksten J.P....Haglund C. (2008)
    246. Hereditary chronic pancreatitis. (PubMed id 17204147)9 Rosendahl J....Teich N. (2007)
    247. Editorial comment on: Increased expression of tumor-associated trypsin inhibitor, TATI, in prostate cancer and in androgen-independent 22Rv1 cells. (PubMed id 17306439)9 Schalken J. (2007)
    248. Editorial comment on: Increased expression of tumor-associated trypsin inhibitor, TATI, in prostate cancer and in androgen-independent 22Rv1 cells. (PubMed id 17306442)9 Edwards J. and Leung H.Y. (2007)
    249. What are the useful biological and functional markers of early-stage chronic pancreatitis? (PubMed id 17238031)9 LAPhr J.M. (2007)
    250. Recurrent idiopathic pancreatitis in familial adenomatous polyposis: report of a case-series and review of the literature. (PubMed id 17318339)9 van Esch A.A....Nagengast F.M. (2007)
    251. SPINK1 variants in young-onset pancreatic cancer. (PubMed id 17653660)9 Hucl T....LAPhr M. (2007)
    252. [Tolerance of enteral nutrition in children with acute pancreatitis] (PubMed id 17625278)9 Kudzin J....Wasowska-KrA^likowska K. (2007)
    253. [SPINK1 N34S mutation as a possible cause of chronic pancreatitis in a patient with familial background] (PubMed id 17641557)9 Oh H.C....Kim M.H. (2007)
    254. Application of proteomic technology in identifying pa ncreatic secretory trypsin inhibitor variants in urine of patients with pancrea titis. (PubMed id 16254194)9 Valmu L....Stenman U.H. (2006)
    255. Pathophysiology of SPINK mutations in pancreatic deve lopment and disease. (PubMed id 16632097)9 Liddle R.A. (2006)
    256. Recurrent acute and chronic pancreatitis in two brothers with familial chylomicronemia syndrome. (PubMed id 16552344)9 Truninger K....Ammann R.W. (2006)
    257. Effects of cigarette smoking on serum fluoride concen trations and renal function integrity after 1 MAC-h sevoflurane anaesthesia. (PubMed id 16923094)9 Laisalmi M....Lindgren L. (2006)
    258. Gene-environment factors that contribute to alcoholic pancreatitis in humans. (PubMed id 16958673)9 Whitcomb D.C. (2006)
    259. Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis. (PubMed id 16492714)9 Mahurkar S....Chandak G.R. (2006)
    260. A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis. (PubMed id 16699518)9 Witt H....Ferec C. (2006)
    261. Silencing of the hydra serine protease inhibitor Kaza l1 gene mimics the human SPINK1 pancreatic phenotype. (PubMed id 16478786)9 Chera S....Galliot B. (2006)
    262. Chronic pancreatitis. (PubMed id 17090903)9 Lindley K.J. (2006)
    263. Chronic pancreatitis with pancreaticolithiasis and pseudocyst in a 5-year-old boy with homozygous SPINK1 mutation. (PubMed id 15875176)9 KA1hn A.C....Hirsch W. (2005)
    264. Alcoholic pancreatitis: new insights into an old disease. (PubMed id 15802096)9 Gullo L....Manca M. (2005)
    265. [Pancreatitis--etiology and pathogenesis] (PubMed id 16301844)9 Kim C.D. (2005)
    266. Mutations of the SPINK1 gene and their relation to ch ronic pancreatitis. (PubMed id 15980659)9 Keim V. (2005)
    267. Genetic polymorphisms in alcoholic pancreatitis. (PubMed id 16508289)9 Whitcomb D.C. (2005)
    268. [Hereditary pancreatitis] (PubMed id 15725720)9 Kim Y.T. (2005)
    269. New insights into juvenile parotitis. (PubMed id 16303695)9 Kolho K.L....PitkAoranta A. (2005)
    270. Acute pancreatitis in a young girl with the Netherton syndrome. (PubMed id 16291148)9 Soreide K....Soreide J.A. (2005)
    271. Relapsing pancreatitis due to a novel compound heterozygosity in the CFTR gene involving the second most common mutation in central and eastern Europe [CFTRdele2,3(21 kb)]. (PubMed id 15775704)9 Lamprecht G....Gregor M. (2005)
    272. Clinical characterization of patients with idiopathic chronic pancreatitis and SPINK1 Mutations. (PubMed id 15513391)9 Schneider A....Whitcomb D.C. (2004)
    273. Cyst fluid tumor-associated trypsin inhibitor may be helpful in the differentiation of cystic pancreatic lesions. (PubMed id 15239993)9 RAoty S....Nordback I. (2004)
    274. Genetic counseling for hereditary pancreatitis--the role of molecular genetics testing for the cationic trypsinogen gene, cystic fibrosis and serine protease inhibitor Kazal type 1. (PubMed id 15528021)9 Ellis I. (2004)
    275. Cationic trypsinogen mutations and pancreatitis. (PubMed id 15528017)9 Howes N....Neoptolemos J.P. (2004)
    276. SPINK1 mutations and phenotypic expression in patients with pancreatitis associated with trypsinogen mutations. (PubMed id 12676913)9 Weiss F.U....Lerch M.M. (2003)
    277. Tumor-associated trypsinogen-2 (trypsinogen-2) activates procollagenases (MMP-1, -8, -13) and stromelysin-1 (MMP-3) and degrades type I collagen. (PubMed id 12731883)9 Moilanen M....Salo T. (2003)
    278. Analysis of tumour necrosis factor alpha and interleukin 10 promotor variants in patients with chronic pancreatitis. (PubMed id 14560157)9 Beranek H....Keim V. (2003)
    279. Motion--genetic testing is useful in the diagnosis of nonhereditary pancreatic conditions: arguments for the motion. (PubMed id 12560855)9 Whitcomb D.C. (2003)
    280. From acute to chronic pancreatitis: the role of mutations in the pancreatic secretory trypsin inhibitor gene. (PubMed id 12629264)9 Hirota M....Ogawa M. (2003)
    281. Genetic polymorphisms in alcoholic pancreatitis. (PubMed id 12828958)9 Hanck C....Whitcomb D.C. (2003)
    282. Genetic predisposition to alcoholic chronic pancreatitis. (PubMed id 14576495)9 Whitcomb D.C. (2003)
    283. Identification of patients with genetic risk factors of pancreatitis: impact on treatment and cancer prevention. (PubMed id 14752225)9 Keim V. (2003)
    284. Tumor-associated trypsin inhibitor. (PubMed id 12142374)9 Stenman U.H. (2002)
    285. Relevance of variants in serum antiproteinases for the course of chronic pancreatitis. (PubMed id 11916201)9 Teich N.... Keim V. (2002)
    286. Genetics and pancreatic disease. (PubMed id 17033331)9 Schneider A....Whitcomb D.C. (2002)
    287. SPINK1 mutations in chronic pancreatitis. (PubMed id 11265668)9 Witt H....Becker M. (2001)
    288. The levels of trypsinogen isoenzymes in ovarian tumour cyst fluids are associated with promatrix metalloproteinase-9 but not promatrix metalloproteinase-2 activation. (PubMed id 11355948)9 Paju A....Stenman U.H. (2001)
    289. Quantitative trait locus analysis for chronic pancreatitis and diabetes mellitus in the WBN/Kob rat. (PubMed id 11414764)9 Tsuji A....Nishimura M. (2001)
    290. Low prevalence of SPINK1 gene mutations in adult patients with chronic idiopathic pancreatitis. (PubMed id 11368029)9 Ockenga J....Stuhrmann M. (2001)
    291. Hereditary pancreatitis in Japan: a review of pancreatitis-associated gene mutations. (PubMed id 12120222)9 Nishimori I. and Onishi S. (2001)
    292. Chronic pancreatitis. (PubMed id 17031196)9 Chari S.T. and DiMagno E.P. (2001)
    293. Relationship between renal function and blood level of chromogranin A. (PubMed id 11499560)9 Tramonti G....Bianchi C. (2001)
    294. High frequency of the N34S mutation in the SPINK1 gene in chronic pancreatitis detected by a new PCR-RFLP assay. (PubMed id 11343313)9 Plendl H....Grote W. (2001)
    295. Do point mutations in the PSTI (SPINK1) gene truly co ntribute to the pathogenesis of chronic pancreatitis? (PubMed id 11578072)9 Shimosegawa T. (2001)
    296. Renal function and serum concentration of five tumor markers (TATI, SCC, CYFRA 21-1, TPA, and TPS) in patients without evidence of neoplasia. (PubMed id 10757127)9 Tramonti G....Bianchi C. (2000)
    297. Down-regulation of trypsinogen-2 expression by chemically modified tetracyclines: association with reduced cancer cell migration. (PubMed id 10797274)9 Lukkonen A....Stenman U.H. (2000)
    298. Clinical tumour markers in ovarian cancer. (PubMed id 9511849)9 Mazurek A....Pluygers E. (1998)
    299. Markers supplementing CA 125 in ovarian cancer. (PubMed id 7741989)9 Stenman U.H....Lehtovirta P. (1995)
    300. [Spontaneous rupture of the ureter caused by metastatic ureteric tumor: a case report] (PubMed id 7900570)9 Yoshimoto T....Kuro R. (1995)
    301. Multivariate analysis of six serum tumor markers (CEA, CA 50, CA 242, TPA, TPS, TATI) and conventional laboratory tests in the diagnosis of hepatopancreatobiliary malignancy. (PubMed id 8669855)9 Pasanen P.A....Alhava E. (1995)
    302. Overexpression of pancreatic secretory trypsin inhibitor in pancreatic cancer. Evaluation of its biological function as a growth factor. (PubMed id 8195643)9 Ohmachi Y....Mori T. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6690 HGNC: 11244 AceView: SPINK1andMGC23985 Ensembl:ENSG00000164266 euGenes: HUgn6690
    ECgene: SPINK1 H-InvDB: SPINK1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPINK1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SPINK1 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/SPINK1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SPINK1 gene:
    Search GeneIP for patents involving SPINK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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