Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SPINK1 Gene

protein-coding   GIFtS: 61
GCID: GC05M147184

Serine Peptidase Inhibitor, Kazal Type 1

(Previous names: serine protease inhibitor, Kazal type 1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Serine Peptidase Inhibitor, Kazal Type 11 2     Tumor-Associated Trypsin Inhibitor2 3
PSTI2 3 5     PCTT2 5
TATI2 3 5     TCP2 5
Serine Protease Inhibitor, Kazal Type 11 2     Spink32
Serine Protease Inhibitor Kazal-Type 12 3     Pancreatic Secretory Trypsin Inhibitor2

External Ids:    HGNC: 112441   Entrez Gene: 66902   Ensembl: ENSG000001642667   OMIM: 1677905   UniProtKB: P009953   

Export aliases for SPINK1 gene to outside databases

Previous GC identifers: GC05M147236 GC05M147785 GC05M147232 GC05M142351


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SPINK1 Gene:
The protein encoded by this gene is a trypsin inhibitor, which is secreted from pancreatic acinar cells into
pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of
zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary
pancreatitis and tropical calcific pancreatitis. (provided by RefSeq, Oct 2008)

GeneCards Summary for SPINK1 Gene:
SPINK1 (serine peptidase inhibitor, Kazal type 1) is a protein-coding gene. Diseases associated with SPINK1 include fibrocalculous pancreatic diabetes, and parotitis. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and endopeptidase inhibitor activity.

UniProtKB/Swiss-Prot: ISK1_HUMAN, P00995
Function: This is a trypsin inhibitor, its physiological function is to prevent the trypsin-catalyzed premature
activation of zymogens within the pancreas

Gene Wiki entry for SPINK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000005.10  NT_029289.12  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPINK1 gene promoter:
         COUP-TF1   p300   Brachyury   POU3F1   COUP   HNF-4alpha2   HNF-3beta   HNF-4alpha1   MZF-1   COUP-TF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPINK1 promoter sequence
   Search Chromatin IP Primers for SPINK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPINK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q32   Ensembl cytogenetic band:  5q32   HGNC cytogenetic band: 5q32

SPINK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPINK1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M147184:  view genomic region     (about GC identifiers)

Start:
147,204,131 bp from pter      End:
147,211,349 bp from pter
Size:
7,219 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ISK1_HUMAN, P00995 (See protein sequence)
Recommended Name: Pancreatic secretory trypsin inhibitor precursor  
Size: 79 amino acids; 8507 Da
3 PDB 3D structures from and Proteopedia for SPINK1:
1CGI (3D)        1CGJ (3D)        1HPT (3D)    

Explore the universe of human proteins at neXtProt for SPINK1: NX_P00995

Explore proteomics data for SPINK1 at MOPED


See SPINK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_003113.2  
ENSEMBL proteins: 
 ENSP00000296695   ENSP00000427376  

SPINK1 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for SPINK1
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for SPINK1
OriGene Protein Over-expression Lysate for SPINK1
OriGene Custom MassSpec
OriGene Custom Protein Services for SPINK1
GenScript Custom Purified and Recombinant Proteins Services for SPINK1
Novus Biologicals SPINK1 Proteins
Novus Biologicals SPINK1 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
ProSpec Recombinant Protein for SPINK1
Cloud-Clone Corp. Proteins for SPINK1

SPINK1 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for SPINK1
OriGene Antibodies for SPINK1
OriGene Custom Antibody Services for SPINK1
Novus Biologicals SPINK1 Antibodies
Abcam antibodies for SPINK1
Cloud-Clone Corp. Antibodies for SPINK1
Search ThermoFisher Antibodies for SPINK1
LSBio Antibodies in human, mouse, rat for SPINK1

SPINK1 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for SPINK1
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for SPINK1
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for SPINK1
Cloud-Clone Corp. CLIAs for SPINK1


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
SPINK: Serine peptidase inhibitors, Kazal type

2 InterPro protein domains:
 IPR002350 Kazal_dom
 IPR001239 Prot_inh_Kazal-m

Graphical View of Domain Structure for InterPro Entry P00995

ProtoNet protein and cluster: P00995

1 Blocks protein domain: IPB001239 Kazal-type serine protease inhibitor signature

UniProtKB/Swiss-Prot: ISK1_HUMAN, P00995
Similarity: Contains 1 Kazal-like domain


SPINK1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: ISK1_HUMAN, P00995
Function: This is a trypsin inhibitor, its physiological function is to prevent the trypsin-catalyzed premature
activation of zymogens within the pancreas

     Genatlas biochemistry entry for SPINK1:
serine protease inhibitor,Kazal type 1,unlikely to be involved in hereditary and sporadic pancreatitis

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004866endopeptidase inhibitor activity TAS7142173
GO:0004867serine-type endopeptidase inhibitor activity IEA--
GO:0005515protein binding IPI14507909
GO:0030414peptidase inhibitor activity ----
     
SPINK1 for ontologies           About GeneDecksing


Phenotypes:
     9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Spink3):
 digestive/alimentary  endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism 
 immune system  integument  mortality/aging  no phenotypic analysis 

SPINK1 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Spink3tm1Kymm for SPINK1

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPINK1
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SPINK1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPINK1
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPINK1

miRNA
Products:
    
miRTarBase miRNAs that target SPINK1:
hsa-mir-1 (MIRT023710)

Block miRNA regulation of human, mouse, rat SPINK1 using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate SPINK1:
hsa-miR-4272
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for SPINK1
Predesigned siRNA for gene silencing in human, mouse, rat SPINK1

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for SPINK1

Clone
Products:
     
OriGene clones in human, mouse for SPINK1 (see all 5)
OriGene ORF clones in mouse, rat for SPINK1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: SPINK1 (NM_003122)
Sino Biological Human cDNA Clone for SPINK1
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPINK1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPINK1

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for SPINK1
Browse ESI BIO Cell Lines and PureStem Progenitors for SPINK1 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPINK1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
ISK1_HUMAN, P00995: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
cytosol1
plasma membrane1
vacuole1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

SPINK1 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for SPINK1 About    
See pathways by source

SuperPathContained pathways About
1Prostate Cancer
Prostate Cancer0.32


1 BioSystems Pathway for SPINK1
    Prostate Cancer



    Pathway & Disease-focused RT2 Profiler PCR Array including SPINK1: 
          Lung Cancer in human mouse rat

Interactions:

    GeneGlobe Interaction Network for SPINK1

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

5 Interacting proteins for SPINK1 (P009952, 3 ENSP000002966954) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
CTRCQ998953, ENSP000003651164I2D: score=2 STRING: ENSP00000365116
ELNP155023, ENSP000002520344I2D: score=2 STRING: ENSP00000252034
NRSN1Q8IZ573, ENSP000003677524I2D: score=1 STRING: ENSP00000367752
TMPRSS15P980733, ENSP000002848854I2D: score=1 STRING: ENSP00000284885
--P007662MINT-25044
About this table

Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0010466negative regulation of peptidase activity ----
GO:0010751negative regulation of nitric oxide mediated signal transduction IEA--
GO:0050732negative regulation of peptidyl-tyrosine phosphorylation IEA--
GO:0060046regulation of acrosome reaction IEA--
GO:0090281negative regulation of calcium ion import IEA--

SPINK1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for SPINK1 (ISK1)

5 Novoseek inferred chemical compound relationships for SPINK1 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
trypsinogen 94.4 64 16327984 (5), 11938439 (2), 12529713 (2), 12939655 (2) (see all 39)
serine 67.5 109 1669448 (3), 7510795 (3), 19737965 (2), 15980664 (2) (see all 57)
creatinine 4.47 12 14633748 (3), 9453997 (2), 14733412 (2), 11499560 (1) (see all 7)
calcium 0 3 16497624 (1), 14641934 (1), 12483248 (1)
fluoride 0 3 14633748 (1), 16923094 (1)



SPINK1 for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for SPINK1 gene: 
NM_003122.3  

Unigene Cluster for SPINK1:

Serine peptidase inhibitor, Kazal type 1
Hs.407856  [show with all ESTs]
Unigene Representative Sequence: AA652500
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000296695(uc003los.2) ENST00000505722 ENST00000510027
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat SPINK1 using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate SPINK1:
hsa-miR-4272
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for SPINK1
Predesigned siRNA for gene silencing in human, mouse, rat SPINK1
Clone
Products:
     
OriGene clones in human, mouse for SPINK1 (see all 5)
OriGene ORF clones in mouse, rat for SPINK1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: SPINK1 (NM_003122)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPINK1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPINK1
Primer
Products:
    
OriGene qPCR primer pairs and template standards for SPINK1
OriGene qSTAR qPCR primer pairs in human, mouse for SPINK1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPINK1
  QuantiTect SYBR Green Assays in human, mouse, rat SPINK1
  QuantiFast Probe-based Assays in human, mouse, rat SPINK1

Additional mRNA sequence: 

BC025790.1 Y00705.1 

4 DOTS entries:

DT.412800  DT.100650810  DT.100646430  DT.427385 

Selected AceView cDNA sequences (see all 91):

BU581710 AI362622 BC025790 BM843311 AI362470 CK905024 BM855672 CB159576 
BM843236 AA436233 AA845156 NM_003122 BU581519 BG141336 BX497081 AA436232 
AI459618 BC021680 BM090780 AA835382 BX108904 BM855485 BX498806 BM855648 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

SPINK1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAGGTAACAG
SPINK1 Expression
About this image


SPINK1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 13) fully expand
 
 Kidney (Urinary System)
         Presumptive Podocytes Podocyte Layer
 
 Epithelial Cells
         Presumptive Podocytes Podocyte Layer
 
 Bone (Muscoskeletal System)
         HyStem+BMP4-induced E15 cells
 
 Cartilage (Muscoskeletal System)
         HyStem+BMP4-induced E15 cells
 
 Heart (Cardiovascular System)
         Atrioventricular Canal Cells Atrioventricular Canal
SPINK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SPINK1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.407856
    Pathway & Disease-focused RT2 Profiler PCR Array including SPINK1: 
          Lung Cancer in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for SPINK1
OriGene qSTAR qPCR primer pairs in human, mouse for SPINK1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPINK1
QuantiTect SYBR Green Assays in human, mouse, rat SPINK1
QuantiFast Probe-based Assays in human, mouse, rat SPINK1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPINK1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of human and mouse.

Orthologs for SPINK1 gene from Selected species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Spink31 , 5 serine peptidase inhibitor, Kazal type 31, 5 74.26(n)1
69.62(a)1
  18 (23.47 cM)5
207301  NM_009258.51  NP_033284.11 
 437280695 


ENSEMBL Gene Tree for SPINK1 (if available)
TreeFam Gene Tree for SPINK1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for SPINK1 gene
10 SIMAP similar genes for SPINK1 using alignment to 4 protein entries:     ISK1_HUMAN (see all proteins):
SPINK9    SPINK5    SPINK6    AGRN    SPINK2    SPINK14
TMEFF2    SPINK4    HEL-S-48e    SPINK13

SPINK1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for SPINK1 (see all 211)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 5 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs171073151,2,,4
C,F,HTropical calcific pancreatitis (TCP)4 pathogenic1147483387(-) TTACAA/GTGAAC 2 N S mis1 ese313Minor allele frequency- G:0.01NA NS EA EU 7121
rs358777201,2,,4
C,FPancreatitis, hereditary (PCTT)4 probable-non-pathogenic1147486814(-) GCCTTG/CGCCCT 2 /F /L mis15Minor allele frequency- C:0.03NA WA EU 6057
VAR_0116884
Pancreatitis, hereditary (PCTT)4--see VAR_0116882 L P mis40--------
rs1119668331,2
C,Fnon-pathogenic1147483325(+) ATTGGA/C/GATAAG 2 P S mis13CSA NA EU 5856
rs1048939391,2
Cpathogenic1147486809(-) GGCCCC/G/TGTTGA 3 P R L mis10--------
rs1048939381,2
Cpathogenic1147486848(-) AGCCAC/TGAAGG 2 T M mis10--------
rs1416342961,2
C,Funknown1147483294(+) CTCACC/TGATTT 2 Q R mis12Minor allele frequency- T:0.00NA EU 5673
rs1132328021,2
F--147205106(+) TTCAAG/ATGATT 1 -- int11Minor allele frequency- A:0.50CSA 2
rs1840478431,2
--147479479(+) CCAGCC/TACAAT 1 -- ds50010--------
rs37771251,2
C,F,A,H--147479526(+) TTATTC/GCAATC 1 -- ds500139Minor allele frequency- G:0.24EA NA NS WA CSA 4914

HapMap Linkage Disequilibrium report for SPINK1 (147204131 - 147211349 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for SPINK1: --
Human Gene Mutation Database (HGMD): SPINK1
Locus Specific Mutation Databases (LSDB): SPINK1

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing SPINK1
DNA2.0 Custom Variant and Variant Library Synthesis for SPINK1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 167790   
OMIM disorders: 167800  608189  
UniProtKB/Swiss-Prot: ISK1_HUMAN, P00995
  • Pancreatitis, hereditary (PCTT) [MIM:167800]: A disease characterized by pancreas inflammation, permanent
    destruction of the pancreatic parenchyma, maldigestion, and severe abdominal pain attacks. Note=Disease
    susceptibility is associated with variations affecting the gene represented in this entry
  • Tropical calcific pancreatitis (TCP) [MIM:608189]: Idiopathic, juvenile, nonalcoholic form of chronic
    pancreatitis widely prevalent in several tropical countries. It can be associated with fibrocalculous pancreatic
    diabetes (FCPD) depending on both environmental and genetic factors. TCP differs from alcoholic pancreatitis by a
    much younger age of onset, pancreatic calcification, a high incidence of insulin dependent but ketosis resistant
    diabetes mellitus, and an exceptionally high incidence of pancreatic cancer. Note=Disease susceptibility is
    associated with variations affecting the gene represented in this entry

  • Selected diseases for SPINK1 (see all 58):    
    About MalaCards
    fibrocalculous pancreatic diabetes    parotitis    recurrent acute pancreatitis    biliary tract disease
    tropical calcific pancreatitis    spink1-related hereditary pancreatitis    alcoholic pancreatitis    acute pancreatitis
    hereditary pancreatitis    prss1-related hereditary pancreatitis    ovarian cyst    pancreatitis, chronic
    pancreatitis    citrullinemia    netherton syndrome    primary hyperparathyroidism
    fibrosarcoma    hypercalcemia    cystic fibrosis    cervical adenocarcinoma

    3 diseases from the University of Copenhagen DISEASES database for SPINK1:
    Pancreatitis     Pancreatic cancer     Cystic fibrosis

    SPINK1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for SPINK1 gene (see all 55)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreatitis hereditary 92.6 14 17274009 (2), 15084977 (2), 17613931 (1), 19106771 (1) (see all 10)
    chronic pancreatitis 91.4 145 11578065 (5), 11950817 (4), 14641934 (4), 18978175 (3) (see all 77)
    pancreatitis 86.9 105 12560856 (4), 18076731 (4), 10982753 (3), 12743777 (3) (see all 50)
    acute recurrent pancreatitis 83.3 4 19844201 (1), 19593166 (1), 20335783 (1)
    pancreatitis alcoholic 77.9 4 18182741 (2), 18336667 (1), 12822871 (1)
    acute pancreatitis 67.5 14 15782101 (2), 15238770 (2), 17625278 (1), 19844201 (1) (see all 9)
    pancreatic diseases 66.9 9 1791319 (2), 15238770 (1), 1780691 (1), 12120202 (1) (see all 7)
    pancreatic cancer 66.3 33 19737965 (4), 8207049 (4), 15084977 (4), 12649567 (3) (see all 13)
    cystic fibrosis 63.9 43 11938439 (2), 12939655 (2), 1886891 (1), 15758663 (1) (see all 27)
    pancreas divisum 61.2 6 19593166 (3), 17625278 (1)

    Genetic Association Database (GAD): SPINK1
    Human Genome Epidemiology (HuGE) Navigator: SPINK1 (71 documents)

    Export disorders for SPINK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SPINK1 gene, integrated from 10 sources (see all 322) (see top 10):
    (articles sorted by number of sources associating them with SPINK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis. (PubMed id 10835640)1, 2, 4, 9 Witt H.... Becker M. (Nat. Genet. 2000)
    2. SPINK1 is a susceptibility gene for fibrocalculous pancreatic diabetes in subjects from the Indian subcontinent. (PubMed id 12187509)1, 2, 4 Hassan Z.... Hitman G.A. (Am. J. Hum. Genet. 2002)
    3. [Mutations of SPINK1 and PRSS1 gene in Korean patients with chronic pancreatitis]. (PubMed id 15329520)1, 4, 9 Lee K.H....Kim C.Y. (Korean J Gastroenterol 2004)
    4. SPINK1, ADH2, and ALDH2 gene variants and alcoholic chronic pancreatitis in Japan. (PubMed id 18336671)1, 4, 9 Shimosegawa T....Masamune A. (J. Gastroenterol. Hepatol. 2008)
    5. Common SPINK-1 mutations do not predispose to the development of non-alcoholic fatty liver disease. (PubMed id 19502653)1, 4, 9 Oruc N....Akarca U.S. (Ann Hepatol 2009)
    6. Mutations in the serine protease inhibitor Kazal Type 1 (SPINK1) gene in Japanese patients with pancreatitis. (PubMed id 15980664)1, 4, 9 Kume K....Shimosegawa T. (Pancreatology 2005)
    7. The role of CFTR and SPINK-1 mutations in pancreatic disorders in HIV-positive patients: a case-control study. (PubMed id 15238770)1, 4, 9 Felley C....Frossard J.L. (AIDS 2004)
    8. Mutations in serine protease inhibitor Kazal type 1 are strongly associated with chronic pancreatitis. (PubMed id 11950817)1, 4, 9 Drenth J.P....Jansen J.B. (Gut 2002)
    9. Identification of CFTR, PRSS1, and SPINK1 mutations in 381 patients with pancreatitis. (PubMed id 17003641)1, 4, 9 Keiles S. and Kammesheidt A. (Pancreas 2006)
    10. SPINK1 gene mutations and pancreatitis in Japan. (PubMed id 16958672)1, 4, 9 Shimosegawa T....Masamune A. (J. Gastroenterol. Hepatol. 2006)
    11. Absence of PRSS1 mutations and association of SPINK1 trypsin inhibitor mutations in hereditary and non-hereditary chronic pancreatitis. (PubMed id 15082592)1, 4, 9 Chandak G.R....Singh L. (Gut 2004)
    12. Mutations in the SPINK1 gene in idiopathic pancreatitis Italian patients. (PubMed id 12825076)1, 4, 9 Gomez-Lira M....Pignatti P.F. (Eur. J. Hum. Genet. 2003)
    13. SPINK1 and PRSS1 mutations in benign pancreatic hyperenzymemia. (PubMed id 18580441)1, 4, 9 Gullo L....Malesci A. (Pancreas 2008)
    14. Pancreatitis risk in primary hyperparathyroidism: relation to mutations in the SPINK1 trypsin inhibitor (N34S) and the cystic fibrosis gene. (PubMed id 18076731)1, 4, 9 Felderbauer P....Schmidt W.E. (Am. J. Gastroenterol. 2008)
    15. Contribution of the CFTR gene, the pancreatic secretory trypsin inhibitor gene (SPINK1) and the cationic trypsinogen gene (PRSS1) to the etiology of recurrent pancreatitis. (PubMed id 17489851)1, 4, 9 Tzetis M....Nousia-Arvanitakis S. (Clin. Genet. 2007)
    16. Differential roles of the SPINK1 gene mutations in alcoholic and nonalcoholic chronic pancreatitis. (PubMed id 17238043)1, 4, 9 Masamune A....Shimosegawa T. (J. Gastroenterol. 2007)
    17. Two novel severe mutations in the pancreatic secretory trypsin inhibitor gene (SPINK1) cause familial and/or hereditary pancreatitis. (PubMed id 14722925)1, 4, 9 Le MarAcchal C....FAcrec C. (Hum. Mutat. 2004)
    18. CFTR, PRSS1 and SPINK1 mutations in the development of pancreatitis in Brazilian patients. (PubMed id 14526128)1, 4, 9 Bernardino A.L....Zatz M. (JOP 2003)
    19. SPINK1 mutations are associated with multiple phenotypes. (PubMed id 12120224)1, 4, 9 PfA1tzer R.H. and Whitcomb D.C. (Pancreatology 2001)
    20. Genetic mutations in a Spanish population with chronic pancreatitis. (PubMed id 19657220)1, 4, 9 Mora J....FarrAc A. (Pancreatology 2009)
    21. Mutations N34S and P55S of the SPINK1 gene in patients with chronic pancreatitis or pancreatic cancer and in healthy subjects: a report from Finland. (PubMed id 15764155)1, 4, 9 Lempinen M....Stenman U.H. (Scand. J. Gastroenterol. 2005)
    22. Polymorphisms of SPINK1 N34S and CFTR in patients with sporadic and familial pancreatic cancer. (PubMed id 14688470)1, 4, 9 Matsubayashi H....Goggins M. (amp 2003)
    23. The N34S mutation of SPINK1 (PSTI) is associated with a familial pattern of idiopathic chronic pancreatitis but does not cause the disease. (PubMed id 11950815)1, 4, 9 Threadgold J....Neoptolemos J.P. (Gut 2002)
    24. Gene mutations in children with chronic pancreatitis. (PubMed id 12120220)1, 4, 9 Witt H. (Pancreatology 2001)
    25. Analysis of CFTR, SPINK1, PRSS1 and AAT mutations in children with acute or chronic pancreatitis. (PubMed id 16954950)1, 4, 9 SobczyA8ska-Tomaszewska A....Bal J. (J. Pediatr. Gastroenterol. Nutr. 2006)
    26. Lack of association between UGT1A7, UGT1A9, ARP, SPINK1 and CFTR gene polymorphisms and pancreatic cancer in Italian patients. (PubMed id 17072959)1, 4, 9 Piepoli A....Perri F. (World J. Gastroenterol. 2006)
    27. Complete cystic fibrosis transmembrane conductance regulator gene sequencing in patients with idiopathic chronic pancreatitis and controls. (PubMed id 15987793)1, 4, 9 Weiss F.U....Lerch M.M. (Gut 2005)
    28. Mutation analysis of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, the cationic trypsinogen (PRSS1) gene, and the serine protease inhibitor, Kazal type 1 (SPINK1) gene in patients with alcoholic chronic pancreatitis. (PubMed id 12939655)1, 4, 9 Perri F....Andriulli A. (Eur. J. Hum. Genet. 2003)
    29. N34S, a pancreatitis associated SPINK1 mutation, is not associated with sporadic pancreatic cancer. (PubMed id 12649567)1, 4, 9 Teich N....Keim V. (Pancreatology 2003)
    30. Association of SPINK1 gene mutation and CFTR gene polymorphisms in patients with pancreas divisum presenting with idiopathic pancreatitis. (PubMed id 19593166)1, 4, 9 Garg P.K....Shastri S.S. (J. Clin. Gastroenterol. 2009)
    31. Divergent roles of SPINK1 and PRSS2 variants in tropical calcific pancreatitis. (PubMed id 19077465)1, 4, 9 Sundaresan S....Drenth J.P. (Pancreatology 2009)
    32. Mutation analysis of SPINK1 and CFTR gene in Korean patients with alcoholic chronic pancreatitis. (PubMed id 16187186)1, 4, 9 Lee K.H....Yoon Y.B. (Dig. Dis. Sci. 2005)
    33. Pancreatic secretory trypsin inhibitor (SPINK1) gene mutations in patients with acute pancreatitis. (PubMed id 15782101)1, 4, 9 Tukiainen E....Puolakkainen P. (Pancreas 2005)
    34. Determination of the relative contribution of three genes-the cystic fibrosis transmembrane conductance regulator gene, the cationic trypsinogen gene, and the pancreatic secretory trypsin inhibitor gene-to the etiology of idiopathic chronic pancreatitis. (PubMed id 11938439)1, 4, 9 AudrAczet M.P....FAcrec C. (Eur. J. Hum. Genet. 2002)
    35. Connections between genetics and clinical data: Role of MCP-1, CFTR, and SPINK-1 in the setting of acute, acute recurrent, and chronic pancreatitis. (PubMed id 19844201)1, 4, 9 Cavestro G.M....Di Mario F. (Am. J. Gastroenterol. 2010)
    36. SPINK1 N34S is strongly associated with recurrent acute pancreatitis but is not a risk factor for the first or sentinel acute pancreatitis event. (PubMed id 19888199)1, 4, 9 Aoun E....Whitcomb D.C. (Am. J. Gastroenterol. 2010)
    37. Investigation of the SPINK1 N34S mutation in Romanian patients with alcoholic chronic pancreatitis. A clinical analysis based on the criteria of the M-ANNHEIM classification. (PubMed id 19565042)1, 4, 9 Diaconu B.L....Schneider A. (J Gastrointestin Liver Dis 2009)
    38. Tropical calcific pancreatitis and its association with CTRC and SPINK1 (p.N34S) variants. (PubMed id 19404200)1, 4, 9 Derikx M.H....Drenth J.P. (amp 2009)
    39. Association and differential role of PRSS1 and SPINK1 mutation in early-onset and late-onset idiopathic chronic pancreatitis in Chinese subjects. (PubMed id 19433603)1, 4, 9 Chang Y.T....Chang M.C. (Gut 2009)
    40. Pathways to injury in chronic pancreatitis: decoding the role of the high-risk SPINK1 N34S haplotype using meta-analysis. (PubMed id 18414673)1, 4, 9 Aoun E....Whitcomb D.C. (PLoS ONE 2008)
    41. Clinical and radiological outcome of patients suffering from chronic pancreatitis associated with gene mutations. (PubMed id 18953248)1, 4, 9 Frulloni L....Vantini I. (Pancreas 2008)
    42. TCF7L2 gene polymorphisms do not predict susceptibility to diabetes in tropical calcific pancreatitis but may interact with SPINK1 and CTSB mutations in predicting diabetes. (PubMed id 18706099)1, 4, 9 Mahurkar S....Chandak G.R. (BMC Med. Genet. 2008)
    43. The SPINK1 N34S variant is associated with acute pancreatitis. (PubMed id 18617776)1, 4, 9 O'Reilly D.A....Kingsnorth A.N. (amp 2008)
    44. Microsatellite scan identifies new candidate genes for susceptibility to alcoholic chronic pancreatitis in Japanese patients. (PubMed id 19096130)1, 4, 9 Kitahara K....Ota M. (Dis. Markers 2008)
    45. Association of cystic fibrosis transmembrane conductance regulator (CFTR) mutation/variant/haplotype and tumor necrosis factor (TNF) promoter polymorphism in hyperlipidemic pancreatitis. (PubMed id 17981921)1, 4, 9 Chang Y.T....Wong J.M. (Clin. Chem. 2008)
    46. Comprehensive screening for reg1alpha gene rules out association with tropical calcific pancreatitis. (PubMed id 17990360)1, 4, 9 Mahurkar S....Chandak G.R. (World J. Gastroenterol. 2007)
    47. Lack of significant association of an insertion/deletion polymorphism in the angiotensin converting enzyme (ACE) gene with tropical calcific pancreatitis. (PubMed id 17163998)1, 4, 9 Bhaskar S....Chandak G.R. (BMC Gastroenterol 2006)
    48. Association of rare SPINK1 gene mutation with another base substitution in chronic pancreatitis patients. (PubMed id 16981266)1, 4, 9 Kalinin V.N....Yekebas E.F. (World J. Gastroenterol. 2006)
    49. The SPINK1 N34S mutation is not associated with Type 2 diabetes mellitus in a population of the USA. (PubMed id 15910626)1, 4, 9 Schneider A....Whitcomb D.C. (Diabet. Med. 2005)
    50. Limited contribution of the SPINK1 N34S mutation to the risk and severity of alcoholic chronic pancreatitis: a report from the United States. (PubMed id 12822871)1, 4, 9 Schneider A....Whitcomb D.C. (Dig. Dis. Sci. 2003)
    51. Germline mutations in CFTR and PSTI genes in chronic pancreatitis patients. (PubMed id 12452372)1, 4, 9 Gaia E....Carlo A. (Dig. Dis. Sci. 2002)
    52. Tropical calcific pancreatitis: strong association with SPINK1 trypsin inhibitor mutations. (PubMed id 12360463)1, 4, 9 Bhatia E....Witt H. (Gastroenterology 2002)
    53. SPINK1/PSTI mutations are associated with tropical pancreatitis and type II diabetes mellitus in Bangladesh. (PubMed id 12360464)1, 4, 9 Schneider A....Whitcomb D.C. (Gastroenterology 2002)
    54. Mutations of the serine protease inhibitor, Kazal type 1 gene, in patients with idiopathic chronic pancreatitis. (PubMed id 12014716)1, 4, 9 Truninger K....Becker M. (Am. J. Gastroenterol. 2002)
    55. Mutations in the pancreatic secretory trypsin inhibitor gene (PSTI/SPINK1) rather than the cationic trypsinogen gene (PRSS1) are significantly associated with tropical calcific pancreatitis. (PubMed id 12011155)1, 2, 9 Chandak G.R....Singh L. (J. Med. Genet. 2002)
    56. Combined bicarbonate conductance-impairing variants in CFTR and SPINK1 variants are associated with chronic pancreatitis in patients without cystic fibrosis. (PubMed id 20977904)1, 4 Schneider A....Whitcomb D.C. (Gastroenterology 2011)
    57. Association analyses of genetic polymorphisms of GSTM1, GSTT1, NQO1, NAT2, LPL, PRSS1, PSTI, and CFTR with chronic alcoholic pancreatitis in Japan. (PubMed id 18986377)1, 4 Maruyama K....Otsuki M. (Alcohol. Clin. Exp. Res. 2010)
    58. Genetic, epidemiological, and clinical aspects of hereditary pancreatitis: a population-based cohort study in Denmark. (PubMed id 20502448)1, 4 Joergensen M.T....Schaffalitzky de Muckadell O.B. (Am. J. Gastroenterol. 2010)
    59. Idiopathic chronic pancreatitis in India: phenotypic characterisation and strong genetic susceptibility due to SPINK1 and CFTR gene mutations. (PubMed id 20551465)1, 4 Midha S....Garg P.K. (Gut 2010)
    60. Incidence, prevalence, etiology, and prognosis of first-time chronic pancreatitis in young patients: a nationwide cohort study. (PubMed id 20108119)1, 4 Joergensen M....de Muckadell O.B. (Dig. Dis. Sci. 2010)
    61. Association of genetic variants with chronic kidney disease in individuals with different lipid profiles. (PubMed id 19578796)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2009)
    62. Fine mapping of the CELIAC2 locus on chromosome 5q31-q33 in the Finnish and Hungarian populations. (PubMed id 19845895)1, 4 Koskinen L.L....Saavalainen P. (Tissue Antigens 2009)
    63. Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population: role of serine protease inhibitor Kazal 1type and alcohol. (PubMed id 18680227)1, 4 Muddana V....Whitcomb D.C. (World J. Gastroenterol. 2008)
    64. The SPINK gene family and celiac disease susceptibility. (PubMed id 17333166)1, 4 Wapenaar M.C....Wijmenga C. (Immunogenetics 2007)
    65. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    66. Mutational screening of patients with nonalcoholic chronic pancreatitis: identification of further trypsinogen variants. (PubMed id 11866271)1, 4 Teich N.... Keim V. (Am. J. Gastroenterol. 2002)
    67. Mutational analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene in hereditary and sporadic chronic pancreatitis. (PubMed id 10691414)1, 2 Chen J.-M.... Ferec C. (J. Med. Genet. 2000)
    68. Solution structure of a variant of human pancreatic secretory trypsin inhibitor determined by nuclear magnetic resonance spectroscopy. (PubMed id 8433367)1, 2 Klaus W. and Schomburg D. (J. Mol. Biol. 1993)
    69. Three-dimensional structure of a recombinant variant of human pancreatic secretory trypsin inhibitor (Kazal type). (PubMed id 1613792)1, 2 Hecht H.-J.... Schomburg D. (J. Mol. Biol. 1992)
    70. Primary structure of human pancreatic secretory trypsin inhibitor (PSTI) gene. (PubMed id 3501289)1, 2 Horii A.... Matsubara K. (Biochem. Biophys. Res. Commun. 1987)
    71. Expression of pancreatic secretory trypsin inhibitor gene in neoplastic tissues. (PubMed id 2961612)1, 2 Tomita N.... Matsubara K. (FEBS Lett. 1987)
    72. Molecular cloning and nucleotide sequence of human pancreatic secretory trypsin inhibitor (PSTI) cDNA. (PubMed id 3877508)1, 2 Yamamoto T....Matsubara K. (Biochem. Biophys. Res. Commun. 1985)
    73. Purification and characterization of a tumor-associated trypsin inhibitor from the urine of a patient with ovarian cancer. (PubMed id 7142173)1, 2 Huhtala M.-L.... Stenman U.-H. (J. Biol. Chem. 1982)
    74. The primary structure of the human pancreatic secretory trypsin inhibitor. Amino acid sequence of the reduced S-aminoethylated protein. (PubMed id 843082)1, 2 Bartelt D.C.... Greene L.J. (Arch. Biochem. Biophys. 1977)
    75. Co-expression of trypsin and tumour-associated trypsin inhibitor (TATI) in colorectal adenocarcinomas. (PubMed id 12973686)1, 9 Solakidi S....Sekeris C.E. (Histol. Histopathol. 2003)
    76. Differential expression of trypsinogen and tumor-associated trypsin inhibitor (TATI) in bladder cancer. (PubMed id 16327984)1, 9 Hotakainen K....Stenman U.H. (Int. J. Oncol. 2006)
    77. Minigene analysis of intronic variants in common SPINK1 haplotypes associated with chronic pancreatitis. (PubMed id 18978175)1, 9 Kereszturi E....Sahin-TA^th M. (Gut 2009)
    78. Tumour-associated trypsin inhibitor, carcinoembryonic antigen and acute-phase reactant proteins CRP and alpha1-antitrypsin in patients with gastrointestinal malignancies. (PubMed id 14675563)1, 9 Solakidi S....Sekeris C.E. (Clin. Biochem. 2004)
    79. Association of SPINK1 expression and TMPRSS2:ERG fusion with prognosis in endocrine-treated prostate cancer. (PubMed id 20442300)1, 9 Leinonen K.A....Visakorpi T. (Clin. Cancer Res. 2010)
    80. The role of SPINK1 in ETS rearrangement-negative prostate cancers. (PubMed id 18538735)1, 9 Tomlins S.A....Chinnaiyan A.M. (Cancer Cell 2008)
    81. N34S mutation in the SPINK1 gene is not associated with alternative splicing. (PubMed id 17446841)1, 9 Masamune A....Shimosegawa T. (Pancreas 2007)
    82. Detection of a large genomic deletion in the pancreatic secretory trypsin inhibitor (SPINK1) gene. (PubMed id 16823394)1, 9 Masson E....FAcrec C. (Eur. J. Hum. Genet. 2006)
    83. Hereditary pancreatitis as the premalignant disease: a Japanese case of pancreatic cancer involving the SPINK1 gene mutation N34S. (PubMed id 15084977)4, 9 Masamune A....Shimosegawa T. (Pancreas 2004)
    84. Identification of genes up-regulated in urothelial tumors: the 67-kd laminin receptor and tumor-associated trypsin inhibitor. (PubMed id 12875970)1, 9 Diggle C.P....Harnden P. (Am. J. Pathol. 2003)
    85. Analysis of PRSS1 and SPINK1 mutations in Korean patients with idiopathic and familial pancreatitis. (PubMed id 18852684)1, 9 Oh H.C....Kim G.H. (Pancreas 2009)
    86. Missense mutations in pancreatic secretory trypsin inhibitor (SPINK1) cause intracellular retention and degradation. (PubMed id 17525091)1, 9 KirA!ly O....Sahin-TA^th M. (Gut 2007)
    87. Co-inheritance of a novel deletion of the entire SPINK1 gene with a CFTR missense mutation (L997F) in a family with chronic pancreatitis. (PubMed id 17681820)1, 9 Masson E....FAcrec C. (Mol. Genet. Metab. 2007)
    88. High tissue expression of tumour-associated trypsin inhibitor (TATI) associates with a more favourable prognosis in gastric cancer. (PubMed id 15810949)1, 9 Wiksten J.P....Haglund C. (Histopathology 2005)
    89. Serine protease inhibitor Kazal type 1 mutations and pancreatitis. (PubMed id 15528018)1, 9 Schneider A. (Gastroenterol. Clin. North Am. 2004)
    90. High expression of tumour-associated trypsin inhibitor correlates with liver metastasis and poor prognosis in colorectal cancer. (PubMed id 19384300)1, 9 Gaber A....Birgisson H. (Br. J. Cancer 2009)
    91. Urinary matrix metalloproteinase -8, -9, -14 and their regulators (TRY-1, TRY-2, TATI) in patients with diabetic nephropathy. (PubMed id 18428024)1, 9 Lauhio A....Honkanen E. (Ann. Med. 2008)
    92. Autocrine induction of invasion and metastasis by tumor-associated trypsin inhibitor in human colon cancer cells. (PubMed id 18317448)1, 9 Gouyer V....Huet G. (Oncogene 2008)
    93. Novel mutations in the calcium sensing receptor gene in tropical chronic pancreatitis in India. (PubMed id 18938753)4, 9 Murugaian E.E....Vallath B. (Scand. J. Gastroenterol. 2008)
    94. Screening for human cationic trypsinogen (PRSS1) and trypsinogen inhibitor gene (SPINK1) mutations in a Finnish family with hereditary pancreatitis. (PubMed id 17613931)1, 9 RAoty S....Herzig K.H. (Scand. J. Gastroenterol. 2007)
    95. Cationic trypsinogen and pancreatic secretory trypsin inhibitor gene mutations in neonatal hypertrypsinaemia. (PubMed id 12529713)1, 9 Patuzzo C....Pignatti P.F. (Eur. J. Hum. Genet. 2003)
    96. SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis. (PubMed id 10982753)1, 9 PfA1tzer R.H....Whitcomb D.C. (Gastroenterology 2000)
    97. Mutations in the calcium-sensing receptor: a new genetic risk factor for chronic pancreatitis? (PubMed id 16497624)1, 9 Felderbauer P....Schmidt W.E. (Scand. J. Gastroenterol. 2006)
    98. A novel SPINK1 gene mutation, c.206C&gt;T, in a Thai patient with chronic alcoholic pancreatitis. (PubMed id 18182741)1, 9 Rerknimitr R....Snabboon T. (JOP 2008)
    99. Characterization of ETS gene aberrations in select histologic variants of prostate carcinoma. (PubMed id 19465903)1, 9 Han B....Shah R.B. (Mod. Pathol. 2009)
    100. Serine protease inhibitor kazal type 1 mutations and pancreatitis. (PubMed id 15749232)1, 9 Schneider A. (Clin. Lab. Med. 2005)
    101. Chronic parotitis: not another SPINKosis. (PubMed id 15753612)1, 9 Gundling F....Teich N. (Dig Dis 2004)
    102. Acute pancreatitis in the early stages of pregnancy associated with a PSTI gene mutation. (PubMed id 15367892)1, 9 Inoue N....Funakoshi A. (Pancreas 2004)
    103. Human mesotrypsin is a unique digestive protease specialized for the degradation of trypsin inhibitors. (PubMed id 14507909)1, 9 Szmola R.... Sahin-Toth M. (J. Biol. Chem. 2003)
    104. Analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene mutations in Japanese patients with chronic pancreatitis. (PubMed id 11355022)1, 9 Kaneko K....Horii A. (J. Hum. Genet. 2001)
    105. Clinical and morphological characteristics of sporadic genetically determined pancreatitis as compared to idiopathic pancreatitis: higher risk of pancreatic cancer in CFTR variants. (PubMed id 23751316)1 Hamoir C....Deprez P.H. (Digestion 2013)
    106. The relationship between serum tumor-associated trypsin inhibitor levels and clinicopathologicalA parameters in patientsA with gastric cancer. (PubMed id 24254562)1 Kemik O....Tuzun S. (Eur Rev Med Pharmacol Sci 2013)
    107. A high-density tissue microarray from patients with clinically localized prostate cancer reveals ERG and TATI exclusivity in tumor cells. (PubMed id 23459095)1 Lippolis G....Bjartell A. (Prostate Cancer Prostatic Dis. 2013)
    108. CFTR, SPINK1, CTRC and PRSS1 variants in chronic pancreatitis: is the role of mutated CFTR overestimated? (PubMed id 22427236)1 Rosendahl J....Witt H. (Gut 2013)
    109. SPINK1 expression is tightly linked to 6q15- and 5q21-deleted ERG-fusion negative prostate cancers but unrelated to PSA recurrence. (PubMed id 23843146)1 Grupp K....Wilczak W. (Prostate 2013)
    110. Molecular dynamics simulations reveal structural instability of human trypsin inhibitor upon D50E and Y54H mutations. (PubMed id 22955423)1 Mokmak W....Tongsima S. (J Mol Model 2013)
    111. Novel dual-color immunohistochemical methods for detecting ERG-PTEN and ERG-SPINK1 status in prostate carcinoma. (PubMed id 23348902)1 Bhalla R....Palanisamy N. (Mod. Pathol. 2013)
    112. Global gene expression profiling reveals SPINK1 as a potential hepatocellular carcinoma marker. (PubMed id 23527199)1 Marshall A....Odom D.T. (PLoS ONE 2013)
    113. The contribution of the SPINK1 c.194+2T&gt;C mutation to the clinical course of idiopathic chronic pancreatitis in Chinese patients. (PubMed id 23017645)1 Sun C....Li Z. (Dig Liver Dis 2013)
    114. Screening of R122H and N29I mutations in the PRSS1 gene and N34S mutation in the SPINK1 gene in Mexican pediatric patients with acute and recurrent pancreatitis. (PubMed id 22699143)1 SA!nchez-RamA-rez C.A....SA!nchez-Corona J. (Pancreas 2012)
    115. Is the SPINK1 variant p.N34S overrepresented in patients with acute pancreatitis? (PubMed id 22228370)1 JA...de Muckadell O.B. (amp 2012)
    116. Tumour-associated trypsin inhibitor TATI is a prognostic marker in colorectal cancer. (PubMed id 22508321)1 Koskensalo S....Haglund C. (Oncology 2012)
    117. Genetic prevalence and characteristics in children with recurrent pancreatitis. (PubMed id 22094894)1 Sultan M....Venkatasubramani N. (J. Pediatr. Gastroenterol. Nutr. 2012)
    118. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    119. The N34S mutation of the SPINK1 gene and alcoholic chronic pancreatitis. (PubMed id 22751291)1 CichoA1-Lach H....Korolczuk A. (Pol. Arch. Med. Wewn. 2012)
    120. Functional analysis of eight missense mutations in the SPINK1 gene. (PubMed id 22343981)1 Boulling A....FAcrec C. (Pancreas 2012)
    121. Phase II study of cytarabine in men with docetaxel-refractory, castration-resistant prostate cancer with evaluation of TMPRSS2-ERG and SPINK1 as serum biomarkers. (PubMed id 22313860)1 Dhani N.C....Joshua A.M. (BJU Int. 2012)
    122. Creatinine clearance, cystatin C, beta2-microglobulin and TATI as markers of renal function in patients with proteinuria. (PubMed id 22307441)1 Tramonti G....Barsotti G. (J. Nephrol. 2012)
    123. Association of tumor-associated trypsin inhibitor (TATI) expression with molecular markers, pathologic features and clinical outcomes of urothelial carcinoma of the urinary bladder. (PubMed id 21739120)1 Patschan O....Bjartell A. (World J Urol 2012)
    124. Do genetic variants in the SPINK1 gene affect the level of serum PSTI? (PubMed id 22526274)1 Kume K....Shimosegawa T. (J. Gastroenterol. 2012)
    125. Genetic basis of chronic pancreatitis in Asia Pacific region. (PubMed id 21323990)1 Reddy D.N. and Prasad S.S. (J. Gastroenterol. Hepatol. 2011)
    126. High incidence of PRSS1 and SPINK1 mutations in Korean children with acute recurrent and chronic pancreatitis. (PubMed id 21415673)1 Lee Y.J....Yoo H.W. (J. Pediatr. Gastroenterol. Nutr. 2011)
    127. Therapeutic targeting of SPINK1-positive prostate cancer. (PubMed id 21368222)1 Ateeq B....Chinnaiyan A.M. (Sci Transl Med 2011)
    128. Combined genomic and phenotype screening reveals secretory factor SPINK1 as an invasion and survival factor associated with patient prognosis in breast cancer. (PubMed id 21656687)1 Soon W.W....Liu E.T. (EMBO Mol Med 2011)
    129. Assessing the pathological relevance of SPINK1 promoter variants. (PubMed id 21610753)1 Boulling A....FAcrec C. (Eur. J. Hum. Genet. 2011)
    130. [Pancreatic secretory trypsin inhibitor gene N34S mutation in patients with idiopathic chronic pancreatitis]. (PubMed id 22363992)1 KucheriavyA- I.u.A....Maev I.V. (amp 2011)
    131. ABO blood group and chronic pancreatitis risk in the NAPS2 cohort. (PubMed id 21792085)1 Greer J.B....Whitcomb D.C. (Pancreas 2011)
    132. The prevalence of cationic trypsinogen (PRSS1) and serine protease inhibitor, Kazal type 1 (SPINK1) gene mutations in Polish patients with alcoholic and idiopathic chronic pancreatitis. (PubMed id 20676769)1 Gasiorowska A....Malecka-Panas E. (Dig. Dis. Sci. 2011)
    133. Effects of radiation therapy on tissue and serum concentrations of tumour associated trypsin inhibitor and their prognostic significance in rectal cancer patients. (PubMed id 21864386)1 Gaber A....JirstrAPm K. (Radiat Oncol 2011)
    134. Presence of SPINK-1 variant alters the course of chronic pancreatitis. (PubMed id 21375584)1 Sandhu B....Sanyal A. (J. Gastroenterol. Hepatol. 2011)
    135. Interaction between a novel intronic IVS3+172 variant and N29I mutation in PRSS1 gene is associated with pancreatitis in a Malaysian Chinese family. (PubMed id 21952138)1 Chua K.H....Goh K.L. (Pancreatology 2011)
    136. Multifactorial genesis of pancreatitis in primary hyperparathyroidism: evidence for &quot;protective&quot; (PRSS2) and &quot;destructive&quot; (CTRC) genetic factors. (PubMed id 20625975)1 Felderbauer P....Bulut K. (amp 2011)
    137. Roles of serine protease inhibitor Kazal type 1 (SPINK1) in pancreatic diseases. (PubMed id 22041280)1 Ohmuraya M. and Yamamura K. (Exp. Anim. 2011)
    138. Phenotypic variability of the homozygous IVS3+2T&gt;C mutation in the serine protease inhibitor Kazal type 1 (SPINK1) gene in patients with chronic pancreatitis. (PubMed id 20543535)1 Ota Y....Kikuyama M. (Tohoku J. Exp. Med. 2010)
    139. Hepatitis B and hepatitis C virus replication upregulates serine protease inhibitor Kazal, resulting in cellular resistance to serine protease-dependent apoptosis. (PubMed id 19864383)1 Lamontagne J....Lu X. (J. Virol. 2010)
    140. Increased serum levels of tumour-associated trypsin inhibitor independently predict a poor prognosis in colorectal cancer patients. (PubMed id 20849596)1 Gaber A....JirstrAPm K. (BMC Cancer 2010)
    141. Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans. (PubMed id 19372376)1 Calvo S.E....Mootha V.K. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    142. [Pancreatitis-associated genes and development of pancreatic cancer]. (PubMed id 19654461)1 Masamune A....Shimosegawa T. (Nihon Shokakibyo Gakkai Zasshi 2009)
    143. Genotype-phenotype correlation in 9 patients with tropical pancreatitis and identified gene mutations. (PubMed id 19696993)1 Rajesh G....Balakrishnan V. (Indian J Gastroenterol 2009)
    144. Pancreatic secretory trypsin inhibitor is a major motogenic and protective factor in human breast milk. (PubMed id 19147803)1 Marchbank T....Playford R.J. (Am. J. Physiol. Gastrointest. Liver Physiol. 2009)
    145. Tumor-associated protein SPIK/TATI suppresses serine protease dependent cell apoptosis. (PubMed id 18347987)1 Lu X....Block T.M. (Apoptosis 2008)
    146. Copy number variations in chronic pancreatitis. (PubMed id 19287144)1 Chen J.M....FAcrec C. (Cytogenet. Genome Res. 2008)
    147. Functional analysis of pancreatitis-associated missense mutations in the pancreatic secretory trypsin inhibitor (SPINK1) gene. (PubMed id 17568390)1 Boulling A....FAcrec C. (Eur. J. Hum. Genet. 2007)
    148. Genetic issues in pediatric pancreatitis. (PubMed id 16764792)1 Kandula L....Lowe M.E. (Curr Gastroenterol Rep 2006)
    149. The impact of cystic fibrosis and PSTI/SPINK1 gene mutations on susceptibility to chronic pancreatitis. (PubMed id 15749233)1 Cohn J.A....Jowell P.S. (Clin. Lab. Med. 2005)
    150. Absence of association between SPINK1 trypsin inhibitor mutations and Type 1 or 2 diabetes mellitus in India and Germany. (PubMed id 14595541)1 Bhatia E....Lerch M.M. (Diabetologia 2003)
    151. Gene symbol: Spink1-Omim 167790. Disease: hereditary pancreatitis. (PubMed id 12974284)2 Deybach J.-C.D.... Ruszniewski P. (Hum. Genet. 2003)
    152. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    153. Human pancreatic secretory trypsin inhibitor. Distribution, actions and possible role in mucosal integrity and repair. (PubMed id 9643675)1 Marchbank T....Playford R.J. (Digestion 1998)
    154. Mutation in the 5' noncoding region of the SRY gene in an XY sex-reversed patient. (PubMed id 9452083)1 Poulat F....Berta P. (Hum. Mutat. 1998)
    155. PRSS1-Related Hereditary Pancreatitis (PubMed id 22379635)1 Pagon R.A....Stephens K. (1993)
    156. Pancreatitis Overview (PubMed id 24624459)1 Pagon R.A....Stephens K. (1993)
    157. Three-dimensional structure of the complexes between bovine chymotrypsinogen A and two recombinant variants of human pancreatic secretory trypsin inhibitor (Kazal-type). (PubMed id 1870127)1 Hecht H.J....Schomburg D. (J. Mol. Biol. 1991)
    158. A low-molecular-mass Kazal-type protease inhibitor isolated from rat hepatocytes is identical to rat pancreatic secretory trypsin inhibitor II. Purification and amino acid sequence. (PubMed id 2110056)1 Kido H....Katunuma N. (Eur. J. Biochem. 1990)
    159. Interactions of pancreatic secretory trypsin inhibitor in small intestinal juice: its hydrolysis and protection by intraluminal factors. (PubMed id 2093478)1 Freeman T.C....Calam J. ( international journal of clinical chemistry 1990)
    160. Increased expression of tumor-associated trypsin inhibitor, TATI, in prostate cancer and in androgen-independent 22Rv1 cells. (PubMed id 17306443)9 Paju A....Bjartell A. (Eur. Urol. 2007)
    161. Tumor-associated trypsin inhibitor in normal and malignant renal tissue and in serum of renal-cell carcinoma patients. (PubMed id 10508484)9 Lukkonen A....Stenman U.H. (Int. J. Cancer 1999)
    162. Urinary levels of tumor-associated trypsin inhibitor (TATI) in the detection of transitional cell carcinoma of the urinary bladder. (PubMed id 15963628)9 Shariat S.F....Stenman U.H. (Eur. Urol. 2005)
    163. Effect of intracavitary radiotherapy on tumor-associated trypsin inhibitor (TATI) in patients with cervical and endometrial cancer. (PubMed id 2354815)9 Lehtovirta P....Stenman U.H. (Gynecol. Oncol. 1990)
    164. Serine protease inhibitor Kazal type 1 promotes proliferation of pancreatic cancer cells through the epidermal growth factor receptor. (PubMed id 19737965)9 Ozaki N....Yamamura K. (Mol. Cancer Res. 2009)
    165. Assessment of tumor-associated trypsin inhibitor (TATI) as a marker of renal function. (PubMed id 14733412)9 Tramonti G....Bianchi C. (J. Nephrol. 2003)
    166. TPA, TATI, CEA, AFP, beta-HCG, PSA, SCC, and CA 19-9 for monitoring transitional cell carcinoma of the bladder. (PubMed id 8638540)9 Pectasides D....Athanassiou A. (Am. J. Clin. Oncol. 1996)
    167. Specific expression of the pancreatic-secretory-trypsin-inhibitor (PSTI) gene in hepatocellular carcinoma. (PubMed id 8244568)9 Ohmachi Y....Matsubara K. (Int. J. Cancer 1993)
    168. Expression of trypsinogen-1, trypsinogen-2, and tumor-associated trypsin inhibitor in ovarian cancer: prognostic study on tissue and serum. (PubMed id 15269150)9 Paju A....Stenman U.H. (Clin. Cancer Res. 2004)
    169. Tumor-associated trypsin inhibitor (TATI) and renal function. (PubMed id 9453997)9 Tramonti G....Bianchi C. (Kidney Int. Suppl. 1997)
    170. Tumor-associated trypsin inhibitor (TATI) in primary esophageal carcinoma. (PubMed id 1780688)9 Gion M....Bruscagnin G. (Scand. J. Clin. Lab. Invest. Suppl. 1991)
    171. Comparison of tumor-associated trypsin inhibitor (TATI) with CA125 as a marker for diagnosis and monitoring of epithelial ovarian cancer. (PubMed id 1780685)9 Gadducci A....Fioretti P. (Scand. J. Clin. Lab. Invest. Suppl. 1991)
    172. Overexpression of tumour-associated trypsin inhibitor (TATI) enhances tumour growth and is associated with portal vein invasion, early recurrence and a stage-independent prognostic factor of hepatocellular carcinoma. (PubMed id 17267202)9 Lee Y.C....Hsu H.C. (Eur. J. Cancer 2007)
    173. A novel mutation of the calcium sensing receptor gene is associated with chronic pancreatitis in a family with heterozygous SPINK1 mutations. (PubMed id 14641934)9 Felderbauer P....Schmidt W.E. (BMC Gastroenterol 2003)
    174. TATI (tumor associated trypsin inhibitor) and cancer antigen 125 (CA 125) in patients with early-stage endometrial cancer. (PubMed id 9891532)9 Peters-Engl C....Medl M. (Anticancer Res. 1998)
    175. Tumour-associated trypsin inhibitor and renal cell carcinoma. (PubMed id 7601186)9 Meria P....Le Duc A. (Eur. Urol. 1995)
    176. Tumour-associated trypsin inhibitor (TATI) in patients with colorectal cancer: a comparison with CEA, CA 50 and CA 242. (PubMed id 7667604)9 Pasanen P....Alhava E. (Scand. J. Clin. Lab. Invest. 1995)
    177. Biology and function of tumor-associated trypsin inhibitor, TATI. (PubMed id 1780691)9 Stenman U.H....Itkonen O. (Scand. J. Clin. Lab. Invest. Suppl. 1991)
    178. Concentration of tumor-associated trypsin inhibitor (TATI) in pleural effusions. (PubMed id 2225961)9 Klockars M....Stenman U.H. (Chest 1990)
    179. Tumour-associated trypsin inhibitor (TATI): comparison with CA125 as a preoperative prognostic indicator in advanced ovarian cancer. (PubMed id 7981075)9 Venesmaa P....Ylikorkala O. (Br. J. Cancer 1994)
    180. Evaluation of urine tumor-associated trypsin inhibitor, CYFRA 21-1, and urinary bladder cancer antigen for detection of high-grade bladder carcinoma. (PubMed id 18514770)9 Gkialas I....Lykourinas M. (Urology 2008)
    181. Functional analysis of recombinant pancreatic secretory trypsin inhibitor protein with amino-acid substitution. (PubMed id 12483248)9 Kuwata K....Ogawa M. (J. Gastroenterol. 2002)
    182. Serum levels of tumor associated trypsin inhibitor (TATI) and glomerular filtration rate. (PubMed id 9574455)9 Tramonti G....Bianchi C. (Ren Fail 1998)
    183. Serum levels of the tumour-associated trypsin inhibitor in patients with endometriosis. (PubMed id 8988701)9 Medl M....Leodolter S. (Br J Obstet Gynaecol 1997)
    184. Serum tumour-associated trypsin inhibitor (TATI) and renal function. (PubMed id 8981662)9 Tramonti G....Bianchi C. (Scand. J. Clin. Lab. Invest. 1996)
    185. Tumor-associated trypsin inhibitor (TATI) and cancer antigen 125 (CA125) in patients with epithelial ovarian cancer. (PubMed id 8669854)9 Peters-Engl C....Leodolter S. (Anticancer Res. 1995)
    186. TATI (tumour-associated trypsin inhibitor) as a marker of ovarian cancer. (PubMed id 7734298)9 Medl M....Leodolter S. (Br. J. Cancer 1995)
    187. Tumour-associated trypsin inhibitor in the diagnosis of pancreatic carcinoma. (PubMed id 8207049)9 Pasanen P.A....Alhava E. (J. Cancer Res. Clin. Oncol. 1994)
    188. Transgenic expression of pancreatic secretory trypsin inhibitor-1 rescues SPINK3-deficient mice and restores a normal pancreatic phenotype. (PubMed id 20110462)9 Romac J.M....Liddle R.A. (Am. J. Physiol. Gastrointest. Liver Physiol. 2010)
    189. Signal peptide variants that impair secretion of pancreatic secretory trypsin inhibitor (SPINK1) cause autosomal dominant hereditary pancreatitis. (PubMed id 17274009)9 Kiraly O.... Ferec C. (Hum. Mutat. 2007)
    190. Trypsinogen-1, -2 and tumour-associated trypsin-inhibitor in bile and biliary tract tissues from patients with biliary tract diseases and pancreatic carcinomas. (PubMed id 11347977)9 HedstrAPm J....Stenman U.H. (Scand. J. Clin. Lab. Invest. 2001)
    191. Binding of bovine basic pancreatic trypsin inhibitor (Kunitz) as well as bovine and porcine pancreatic secretory trypsin inhibitor (Kazal) to human cathepsin G: a kinetic and thermodynamic study. (PubMed id 7510795)9 Fioretti E....Ascoli F. (J. Enzym. Inhib. 1993)
    192. Tumor-associated trypsin inhibitor (TATI) in bone diseases. (PubMed id 1780696)9 Rapellino M....Libertucci D. (Scand. J. Clin. Lab. Invest. Suppl. 1991)
    193. Tumor-associated trypsin inhibitor (TATI) in the diagnosis of lung cancer. (PubMed id 1780695)9 Pecchio F....Coni F. (Scand. J. Clin. Lab. Invest. Suppl. 1991)
    194. Tumor-associated trypsin inhibitor in induced and acquired immunodeficiency. Studies on transplanted and HIV-infected patients. (PubMed id 1780693)9 Banfi G....Bonini P.A. (Scand. J. Clin. Lab. Invest. Suppl. 1991)
    195. Tumour-associated trypsin inhibitor (TATI) and cancer antigen 125 (CA 125) in mucinous ovarian tumours. (PubMed id 2310684)9 Mogensen O....Jakobsen A. (Br. J. Cancer 1990)
    196. Tumor-associated trypsin inhibitor and cancer antigen 125 in pelvic masses. (PubMed id 2167279)9 Mogensen O....Jakobsen A. (Gynecol. Oncol. 1990)
    197. Mitochondrial DNA A3243G mutation involved in familial diabetes, chronic intestinal pseudo-obstruction and recurrent pancreatitis. (PubMed id 18955007)9 Verny C....Bonneau D. (amp 2008)
    198. A 93 year old man with the PRSS1 R122H mutation, low SPINK1 expression, and no pancreatitis: insights into phenotypic non-penetrance. (PubMed id 16354799)9 Khalid A....Whitcomb D.C. (Gut 2006)
    199. Mutational analysis of the pancreatic secretory trypsin inhibitor gene in familial and juvenile pancreatitis in Japan. (PubMed id 12743777)9 Kuwata K....Ogawa M. (J. Gastroenterol. 2003)
    200. Motion--genetic testing is useful in the diagnosis of nonhereditary pancreatic conditions: arguments against the motion. (PubMed id 12560856)9 Cohn J.A. (Can. J. Gastroenterol. 2003)
    201. The course of genetically determined chronic pancreatitis. (PubMed id 12853682)9 Keim V....Mossner J. (JOP 2003)
    202. Fluoride metabolism in smokers and non-smokers following enflurane anaesthesia. (PubMed id 14633748)9 Laisalmi M....Lindgren L. (Br J Anaesth 2003)
    203. Idiopathic pancreatitis related to CFTR: complex inheritance and identification of a modifier gene. (PubMed id 12227654)9 Cohn J.A....Jowell P.S. (J. Investig. Med. 2002)
    204. Genetic mutations in exons 3 and 4 of the pancreatic secretory trypsin inhibitor in patients with pancreatitis. (PubMed id 11578065)9 Kuwata K....Ogawa M. (J. Gastroenterol. 2001)
    205. SPINK1/PSTI mutations are associated with tropical pancreatitis in Bangladesh. A preliminary report. (PubMed id 12120202)9 Rossi L....Whitcomb D.C. (Pancreatology 2001)
    206. Evaluation of TATI and CYFRA 21-1 in patients with head and neck squamous cell carcinoma. (PubMed id 9166881)9 Goumas P.D....Nikiforidis G.C. ( journal for oto-rhino-laryngology and its related specialties 1997)
    207. Serum tumor markers CEA, CA 50, TATI, and NSE in lung cancer screening. (PubMed id 8443749)9 JAorvisalo J....Aromaa A. (Cancer 1993)
    208. Squamous cell carcinoma antigen (SCC), carcinoembryonic antigen (CEA), and tumour-associated trypsin inhibitor (TATI) for monitoring head and neck cancer. (PubMed id 8366300)9 Pectasides D....Athanassiou A. (Int. J. Biol. Markers 1993)
    209. Cancer-associated antigen CA 195 in patients with mucinous ovarian tumours: a comparative analysis with CEA, TATI and CA 125 in serum specimens and cyst fluids. (PubMed id 8392219)9 de Bruijn H.W....Aalders J.G. (Tumour Biol. 1993)
    210. The concomitant determination of different serum tumor markers in epithelial ovarian cancer: relevance for monitoring the response to chemotherapy and follow-up of patients. (PubMed id 1544592)9 Fioretti P....Bianchi R. (Gynecol. Oncol. 1992)
    211. [Effects of pH on the formation and dissociation of the complex of trypsin and PSTI]. (PubMed id 1377760)9 Seshimo T....Nakase A. (Nihon Shokakibyo Gakkai Zasshi 1992)
    212. Binding of the bovine and porcine pancreatic secretory trypsin inhibitor (Kazal) to human leukocyte elastase: a thermodynamic study. (PubMed id 1669448)9 Ascenzi P....Menegatti E. (J. Enzym. Inhib. 1991)
    213. Tumor-associated trypsin inhibitor (TATI) in patients with colorectal carcinoma. A critical comparison with CEA. (PubMed id 1780689)9 Catarino M. and Conde R. (Scand. J. Clin. Lab. Invest. Suppl. 1991)
    214. Tumor-associated trypsin inhibitor (TATI) in benign and malignant gastric disease. (PubMed id 1780694)9 Loizate Toricaguena A....Legorburu Escudero J.F. (Scand. J. Clin. Lab. Invest. Suppl. 1991)
    215. Evaluation of TATI and other markers in solid tumors. (PubMed id 1780686)9 Taccone W....Belli M. (Scand. J. Clin. Lab. Invest. Suppl. 1991)
    216. Tumor-associated trypsin inhibitor, TATI, in gastrointestinal cancer and related benign diseases. (PubMed id 1780697)9 Piantino P. and Arosaio E. (Scand. J. Clin. Lab. Invest. Suppl. 1991)
    217. Tumor-associated trypsin inhibitor (TATI) in pleural effusions. (PubMed id 1780690)9 Rapellino M....Ricardi G. (Scand. J. Clin. Lab. Invest. Suppl. 1991)
    218. Tumor markers CA 125, carcinoembryonic antigen and tumor-associated trypsin inhibitor in patients with cervical adenocarcinoma. (PubMed id 2258083)9 Leminen A. (Gynecol. Oncol. 1990)
    219. Expression of pancreatic secretory trypsin inhibitor gene in human colorectal tumor. (PubMed id 2224769)9 Tomita N....Yokouchi H. (Cancer 1990)
    220. A comparison of the usefulness of serum measurements of CA 125, CA 50 and TATI in patients with malignant and benign gynecological pathology. (PubMed id 2379509)9 Gadducci A....Fioretti P. (Eur. J. Gynaecol. Oncol. 1990)
    221. Tumor-associated trypsin inhibitor as a prognostic factor during follow-up of bladder cancer. (PubMed id 12893328)9 Kelloniemi E....Stenman U.H. (Urology 2003)
    222. Pre-operative serum level of tumour-associated trypsin inhibitor and residual tumour size as prognostic indicators in Stage III epithelial ovarian cancer. (PubMed id 9637119)9 Venesmaa P....Paavonen J. (Br J Obstet Gynaecol 1998)
    223. Hereditary pancreatitis in children: surgical implications with special regard to genetic background. (PubMed id 19944211)9 Schmitt F....Podevin G. (J. Pediatr. Surg. 2009)
    224. Comparison of secondary and primary ovarian malignancies reveals differences in their pre- and perioperative characteristics. (PubMed id 16278010)9 Antila R....Heikinheimo O. (Gynecol. Oncol. 2006)
    225. Biochemical models of hereditary pancreatitis. (PubMed id 16632094)9 Sahin-TA^th M. (Endocrinol. Metab. Clin. North Am. 2006)
    226. Reduced CFTR function and the pathobiology of idiopathic pancreatitis. (PubMed id 15758663)9 Cohn J.A. (J. Clin. Gastroenterol. 2005)
    227. [Chronic pancreatitis--pancreas cancer: influence of genetic factors]. (PubMed id 15957615)9 Keim V. (Praxis (Bern 1994) 2005)
    228. Association of trypsin-2 with activation of gelatinase B and collagenase-2 in human bronchoalveolar lavage fluid in vivo. (PubMed id 11585105)9 Prikk K....Sorsa T. (Ann. Med. 2001)
    229. Preoperative serum concentration of hCGbeta as a prognostic factor in ovarian cancer. (PubMed id 11494231)9 Vartiainen J....Alfthan H. (Int. J. Cancer 2001)
    230. Genetic aspects of chronic pancreatitis: insights into aetiopathogenesis and clinical implications. (PubMed id 11775491)9 Truninger K....Witt H. (Swiss Med Wkly 2001)
    231. Squamous cell carcinoma antigen, tumor-associated trypsin inhibitor, and carcinoembryonic antigen for monitoring cervical cancer. (PubMed id 8048392)9 Pectasides D....Athanassiou A. (Am. J. Clin. Oncol. 1994)
    232. [Tissue polypeptide antigen and tumor trypsin inhibitor in pleural effusions of various etiologies]. (PubMed id 1481445)9 Plavec G....NinkoviA8 M. (Vojnosanit Pregl 1992)
    233. Evaluation of tumor-associated trypsin inhibitor (TATI) in women with benign and malignant gynecological disease. (PubMed id 1780683)9 Inaudi P....D'Antona N. (Scand. J. Clin. Lab. Invest. Suppl. 1991)
    234. Evaluation of CEA, CA 19-9, CA-50, CA-195, and TATI with special reference to pancreatic disorders. (PubMed id 1791319)9 Masson P....Andren-Sandberg A. (Int. J. Pancreatol. 1991)
    235. Response to IL-6 stimulation of human hepatoblastoma cells: production of pancreatic secretory trypsin inhibitor. (PubMed id 2119190)9 Yasuda T....Mori T. (Biol. Chem. Hoppe-Seyler 1990)
    236. A comparative evaluation of the ability of serum CA 125, CA 19-9, CA 15-3, CA 50, CA 72-4 and TATI assays in reflecting the course of disease in patients with ovarian carcinoma. (PubMed id 2379512)9 Gadducci A....Fioretti P. (Eur. J. Gynaecol. Oncol. 1990)
    237. Genetic aspects of pancreatitis. (PubMed id 20059346)9 Whitcomb D.C. (Annu. Rev. Med. 2010)
    238. The variable phenotype of the p.A16V mutation of cationic trypsinogen (PRSS1) in pancreatitis families. (PubMed id 19951905)9 Grocock C.J....Greenhalf W. (Gut 2010)
    239. Recurrent acute pancreatitis caused by association of a novel mutation of the calcium-sensing receptor gene and a heterozygous mutation of the SPINK1 gene. (PubMed id 20335783)9 Baudry C....Levy P. (Pancreas 2010)
    240. Alcohol-induced acute pancreatitis: the 'critical mass' concept. (PubMed id 20181433)9 Barreto S.G. and Saccone G.T. (Med. Hypotheses 2010)
    241. Biomarkers in prostate cancer diagnosis and prognosis: beyond prostate-specific antigen. (PubMed id 19325493)9 Fradet Y. (Curr Opin Urol 2009)
    242. Chronic hereditary pancreatitis in a girl with a serine protease inhibitor kazal type I (SPINK-1) gene mutation and a coxsackie type B5 infection. (PubMed id 19106771)9 Groeneweg M....Nieuwenhuis E.E. (Pediatr. Infect. Dis. J. 2009)
    243. Chronic pancreatitis: genetics and pathogenesis. (PubMed id 19453252)9 Chen J.M. and FAcrec C. (Annu Rev Genomics Hum Genet 2009)
    244. Integration of ERG gene mapping and gene-expression profiling identifies distinct categories of human prostate cancer. (PubMed id 19040532)9 Jhavar S....Cooper C.S. (BJU Int. 2009)
    245. Genetic aspects of tropical calcific pancreatitis. (PubMed id 18604651)9 Witt H. and Bhatia E. (amp 2008)
    246. Hereditary chronic pancreatitis. (PubMed id 18206817)9 Teich N. and MAPssner J. (amp 2008)
    247. Individual susceptibility to alcoholic pancreatitis. (PubMed id 18336667)9 Apte M.V....Wilson J.S. (J. Gastroenterol. Hepatol. 2008)
    248. Alcoholic pancreatitis: new pathogenetic insights. (PubMed id 18663346)9 Lucrezio L....Gullo L. (Minerva Med. 2008)
    249. A first-generation multiplex biomarker analysis of urine for the early detection of prostate cancer. (PubMed id 18245462)9 Laxman B....Chinnaiyan A.M. (Cancer Res. 2008)
    250. [Toxicogenetics of antiretroviral treatment (II): neurotoxicity, hepatotoxicity, lactic acidosis, kidney damage, and other adverse effects of antiretroviral drugs]. (PubMed id 18680693)9 SA!nchez HellA-n V. and GutiAcrrez Rodero F. (Enferm. Infecc. Microbiol. Clin. 2008)
    251. Concomitant autoimmune and genetic pancreatitis leads to severe inflammatory conditions. (PubMed id 18442214)9 Frossard J.L....Hadengue A. (World J. Gastroenterol. 2008)
    252. Comparison of the prognostic value of a panel of tissue tumor markers and established clinicopathological factors in patients with gastric cancer. (PubMed id 18751407)9 Wiksten J.P....Haglund C. (Anticancer Res. 2008)
    253. Hereditary chronic pancreatitis. (PubMed id 17204147)9 Rosendahl J....Teich N. (Orphanet J Rare Dis 2007)
    254. Editorial comment on: Increased expression of tumor-associated trypsin inhibitor, TATI, in prostate cancer and in androgen-independent 22Rv1 cells. (PubMed id 17306439)9 Schalken J. (Eur. Urol. 2007)
    255. Editorial comment on: Increased expression of tumor-associated trypsin inhibitor, TATI, in prostate cancer and in androgen-independent 22Rv1 cells. (PubMed id 17306442)9 Edwards J. and Leung H.Y. (Eur. Urol. 2007)
    256. What are the useful biological and functional markers of early-stage chronic pancreatitis? (PubMed id 17238031)9 LAPhr J.M. (J. Gastroenterol. 2007)
    257. Recurrent idiopathic pancreatitis in familial adenomatous polyposis: report of a case-series and review of the literature. (PubMed id 17318339)9 van Esch A.A....Nagengast F.M. (Fam. Cancer 2007)
    258. SPINK1 variants in young-onset pancreatic cancer. (PubMed id 17653660)9 Hucl T....LAPhr M. (J. Gastroenterol. 2007)
    259. [Tolerance of enteral nutrition in children with acute pancreatitis]. (PubMed id 17625278)9 Kudzin J....Wasowska-KrA^likowska K. (Med Wieku Rozwoj 2007)
    260. [SPINK1 N34S mutation as a possible cause of chronic pancreatitis in a patient with familial background]. (PubMed id 17641557)9 Oh H.C....Kim M.H. (Korean J Gastroenterol 2007)
    261. Application of proteomic technology in identifying pancreatic secretory trypsin inhibitor variants in urine of patients with pancreatitis. (PubMed id 16254194)9 Valmu L....Stenman U.H. (Clin. Chem. 2006)
    262. Pathophysiology of SPINK mutations in pancreatic development and disease. (PubMed id 16632097)9 Liddle R.A. (Endocrinol. Metab. Clin. North Am. 2006)
    263. Recurrent acute and chronic pancreatitis in two brothers with familial chylomicronemia syndrome. (PubMed id 16552344)9 Truninger K....Ammann R.W. (Pancreas 2006)
    264. Effects of cigarette smoking on serum fluoride concentrations and renal function integrity after 1 MAC-h sevoflurane anaesthesia. (PubMed id 16923094)9 Laisalmi M....Lindgren L. (Acta Anaesthesiol Scand 2006)
    265. Gene-environment factors that contribute to alcoholic pancreatitis in humans. (PubMed id 16958673)9 Whitcomb D.C. (J. Gastroenterol. Hepatol. 2006)
    266. Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis. (PubMed id 16492714)9 Mahurkar S....Chandak G.R. (Gut 2006)
    267. A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis. (PubMed id 16699518)9 Witt H....FAcrec C. (Nat. Genet. 2006)
    268. Silencing of the hydra serine protease inhibitor Kazal1 gene mimics the human SPINK1 pancreatic phenotype. (PubMed id 16478786)9 Chera S....Galliot B. (J. Cell. Sci. 2006)
    269. Chronic pancreatitis. (PubMed id 17090903)9 Lindley K.J. (Indian J Pediatr 2006)
    270. Chronic pancreatitis with pancreaticolithiasis and pseudocyst in a 5-year-old boy with homozygous SPINK1 mutation. (PubMed id 15875176)9 KA1hn A.C....Hirsch W. (Pediatr Radiol 2005)
    271. Alcoholic pancreatitis: new insights into an old disease. (PubMed id 15802096)9 Gullo L....Manca M. (Curr Gastroenterol Rep 2005)
    272. [Pancreatitis--etiology and pathogenesis]. (PubMed id 16301844)9 Kim C.D. (Korean J Gastroenterol 2005)
    273. Mutations of the SPINK1 gene and their relation to chronic pancreatitis. (PubMed id 15980659)9 Keim V. (Pancreatology 2005)
    274. Genetic polymorphisms in alcoholic pancreatitis. (PubMed id 16508289)9 Whitcomb D.C. (Dig Dis 2005)
    275. [Hereditary pancreatitis]. (PubMed id 15725720)9 Kim Y.T. (Korean J Gastroenterol 2005)
    276. New insights into juvenile parotitis. (PubMed id 16303695)9 Kolho K.L....PitkAoranta A. (Acta Paediatr. 2005)
    277. Acute pancreatitis in a young girl with the Netherton syndrome. (PubMed id 16291148)9 SAPreide K....SAPreide J.A. (J. Pediatr. Surg. 2005)
    278. Relapsing pancreatitis due to a novel compound heterozygosity in the CFTR gene involving the second most common mutation in central and eastern Europe [CFTRdele2,3(21 kb)]. (PubMed id 15775704)9 Lamprecht G....Gregor M. (Pancreatology 2005)
    279. Clinical characterization of patients with idiopathic chronic pancreatitis and SPINK1 Mutations. (PubMed id 15513391)9 Schneider A....Whitcomb D.C. (Scand. J. Gastroenterol. 2004)
    280. Cyst fluid tumor-associated trypsin inhibitor may be helpful in the differentiation of cystic pancreatic lesions. (PubMed id 15239993)9 RAoty S....Nordback I. (J. Gastrointest. Surg. 2004)
    281. Genetic counseling for hereditary pancreatitis--the role of molecular genetics testing for the cationic trypsinogen gene, cystic fibrosis and serine protease inhibitor Kazal type 1. (PubMed id 15528021)9 Ellis I. (Gastroenterol. Clin. North Am. 2004)
    282. Cationic trypsinogen mutations and pancreatitis. (PubMed id 15528017)9 Howes N....Neoptolemos J.P. (Gastroenterol. Clin. North Am. 2004)
    283. SPINK1 mutations and phenotypic expression in patients with pancreatitis associated with trypsinogen mutations. (PubMed id 12676913)9 Weiss F.U....Lerch M.M. (J. Med. Genet. 2003)
    284. Tumor-associated trypsinogen-2 (trypsinogen-2) activates procollagenases (MMP-1, -8, -13) and stromelysin-1 (MMP-3) and degrades type I collagen. (PubMed id 12731883)9 Moilanen M....Salo T. (Biochemistry 2003)
    285. Analysis of tumour necrosis factor alpha and interleukin 10 promotor variants in patients with chronic pancreatitis. (PubMed id 14560157)9 Beranek H....Keim V. (amp 2003)
    286. Motion--genetic testing is useful in the diagnosis of nonhereditary pancreatic conditions: arguments for the motion. (PubMed id 12560855)9 Whitcomb D.C. (Can. J. Gastroenterol. 2003)
    287. From acute to chronic pancreatitis: the role of mutations in the pancreatic secretory trypsin inhibitor gene. (PubMed id 12629264)9 Hirota M....Ogawa M. (JOP 2003)
    288. Genetic polymorphisms in alcoholic pancreatitis. (PubMed id 12828958)9 Hanck C....Whitcomb D.C. (amp 2003)
    289. Genetic predisposition to alcoholic chronic pancreatitis. (PubMed id 14576495)9 Whitcomb D.C. (Pancreas 2003)
    290. Identification of patients with genetic risk factors of pancreatitis: impact on treatment and cancer prevention. (PubMed id 14752225)9 Keim V. (Dig Dis 2003)
    291. Tumor-associated trypsin inhibitor. (PubMed id 12142374)9 Stenman U.H. (Clin. Chem. 2002)
    292. Relevance of variants in serum antiproteinases for the course of chronic pancreatitis. (PubMed id 11916201)9 Teich N.... Keim V. (Scand. J. Gastroenterol. 2002)
    293. Genetics and pancreatic disease. (PubMed id 17033331)9 Schneider A....Whitcomb D.C. (Curr. Opin. Gastroenterol. 2002)
    294. SPINK1 mutations in chronic pancreatitis. (PubMed id 11265668)9 Witt H....Becker M. (Gastroenterology 2001)
    295. The levels of trypsinogen isoenzymes in ovarian tumour cyst fluids are associated with promatrix metalloproteinase-9 but not promatrix metalloproteinase-2 activation. (PubMed id 11355948)9 Paju A....Stenman U.H. (Br. J. Cancer 2001)
    296. Quantitative trait locus analysis for chronic pancreatitis and diabetes mellitus in the WBN/Kob rat. (PubMed id 11414764)9 Tsuji A....Nishimura M. (Genomics 2001)
    297. Low prevalence of SPINK1 gene mutations in adult patients with chronic idiopathic pancreatitis. (PubMed id 11368029)9 Ockenga J....Stuhrmann M. (J. Med. Genet. 2001)
    298. Hereditary pancreatitis in Japan: a review of pancreatitis-associated gene mutations. (PubMed id 12120222)9 Nishimori I. and Onishi S. (Pancreatology 2001)
    299. Chronic pancreatitis. (PubMed id 17031196)9 Chari S.T. and DiMagno E.P. (Curr. Opin. Gastroenterol. 2001)
    300. Relationship between renal function and blood level of chromogranin A. (PubMed id 11499560)9 Tramonti G....Bianchi C. (Ren Fail 2001)
    301. High frequency of the N34S mutation in the SPINK1 gene in chronic pancreatitis detected by a new PCR-RFLP assay. (PubMed id 11343313)9 Plendl H....Grote W. (Am. J. Med. Genet. 2001)
    302. Do point mutations in the PSTI (SPINK1) gene truly contribute to the pathogenesis of chronic pancreatitis? (PubMed id 11578072)9 Shimosegawa T. (J. Gastroenterol. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6690 HGNC: 11244 AceView: SPINK1andMGC23985 Ensembl:ENSG00000164266 euGenes: HUgn6690
    ECgene: SPINK1 H-InvDB: SPINK1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SPINK1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SPINK1 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=SPINK1[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SPINK1 gene:
    Search GeneIP for patents involving SPINK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for SPINK1 (SPINK1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for SPINK1 (SPINK1)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SPINK1   OriGene RNAi products in human, mouse, rat for SPINK1  
     OriGene qPCR primer pairs and template standards for SPINK1   OriGene Protein Over-expression Lysate for SPINK1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SPINK1  
     OriGene qSTAR qPCR primer pairs in human, mouse for SPINK1   OriGene Purified Protein for SPINK1  
     OriGene ORF clones in mouse, rat for SPINK1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SPINK1   OriGene Custom Protein Services for SPINK1  

     
     
     Block miRNA regulation of human, mouse, rat SPINK1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SPINK1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPINK1 Predesigned siRNA for gene silencing in human, mouse, rat SPINK1
     QuantiFast Probe-based Assays in human, mouse, rat SPINK1 QuantiTect SYBR Green Assays in human, mouse, rat SPINK1
     PCR Arrays including human, mouse, rat SPINK1 Search Chromatin IP Primers for SPINK1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPINK1  GeneGlobe Interaction Network for SPINK1
     Regulatory tfbs in SPINK1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SPINK1 GenScript cDNA clones with any tag delivered in your preferred vector for SPINK1
     GenScript Custom Assay Services for SPINK1 GenScript Custom overexpressing Cell Line Services for SPINK1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SPINK1 (ISK1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for SPINK1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SPINK1 antibodies
     SPINK1 proteins
     SPINK1 lysates
     Antibodies for SPINK1
     See all of Abcam's Antibodies, Kits and Proteins for SPINK1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for SPINK1
     Proteins for SPINK1
     Antibodies for SPINK1
     ELISAs for SPINK1
     CLIAs for SPINK1



     Browse ESI BIO Cell Lines and PureStem Progenitors for SPINK1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPINK1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for SPINK1
     SwitchGear Promoter luciferase reporter plasmids for SPINK1
     Search ThermoFisher Antibodies for SPINK1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPINK1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPINK1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SPINK1
     LSBio Antibodies in human, mouse, rat for SPINK1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SPINK1 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4