SPIN4 Gene
protein-coding GIFtS: 43
GCID: GC0XM062568
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|
spindlin family, member 4
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Aliases
for SPIN4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Spindlin Family, Member 41 2 | | FLJ449841 | | Spindlin-41 |
Export aliases for SPIN4 gene to outside databasesPrevious GC identifers: GC0XM062484 GC0XM056393 |
Summaries
for SPIN4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SPIN4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011669.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPIN4 gene promoter:
MAZR ATF-2 MIF-1 Evi-1 E47 HNF-1A NRF-2 HNF-1 ZID NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPIN4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPIN4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq11.1 Ensembl cytogenetic band: Xq11.1 HGNC cytogenetic band: Xq11.1SPIN4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM062568: view genomic region
(about GC identifiers)
Start:
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62,567,107 bp from pter |
End:
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62,571,223 bp from pter |
Size:
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4,117 bases |
Orientation:
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minus strand |
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Proteins
for SPIN4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPIN4_HUMAN, Q56A73 (See
protein sequence)Recommended Name: Spindlin-4 Size: 249 amino acids; 28660 Da
Sequence caution: Sequence=CAI41371.1; Type=Erroneous initiation;
Secondary accessions: Q5JUL2Explore the universe of human proteins at neXtProt for SPIN4: NX_Q56A73
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q56A73
SPIN4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001012986.2
ENSEMBL proteins: ENSP00000364018 ENSP00000334163
Human Recombinant Protein Products:
SPIN4 Antibody Products:
Assay Products for SPIN4: |
Protein
Domains /
Families
for SPIN4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SPIN4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q56A73ProtoNet protein and cluster: Q56A73 1 Blocks protein family: IPB003671 Spindlin/spermiogenesis-specific protein
UniProtKB/Swiss-Prot: SPIN4_HUMAN, Q56A73Similarity: Belongs to the SPIN/STSY family |
Function
for SPIN4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPIN4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPIN4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SPIN4 (NM_001012968) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPIN4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPIN4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPIN4 |
|
Pathways & Interactions
for SPIN4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPIN4
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for SPIN4 (ENSP000003341634) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007276 | gamete generation |
IEA | -- |
SPIN4 for ontologies About GeneDecksing
|
Drugs & Compounds
for SPIN4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPIN4
Search CenterWatch for drugs/clinical trials and news about SPIN4
|
Transcripts
for SPIN4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPIN4 gene: NM_001012968.2 Unigene Cluster for SPIN4: Spindlin family, member 4 Hs.612782 [show with all ESTs]Unigene Representative Sequence: AL8333142 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000374884 ENST00000335144(uc004dvf.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPIN4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPIN4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SPIN4 (NM_001012968) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPIN4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPIN4 |
Additional cDNA sequence: AK021705.1 AK126931.1 AL833314.1 BC035088.1 BC043412.1 BC112360.1 2 DOTS entries: DT.108130 DT.100746759 24/40 AceView cDNA sequences (see all 40): BG059887 BC043412 BM667539 BX282201 BM144682 AL135659 BU069192 AL833314 AK126931 BQ424587 BU688875 CB114602 BG023952 BC035088 CB114607 BG178943 AW582842 AU118795 AI471422 AA776212 AA598803 BE042460 BE042498 BI491676
GeneLoc Exon Structure
|
Expression
for SPIN4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPIN4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTGGATTTT
About this image
See SPIN4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPIN4
SOURCE GeneReport for Unigene cluster: Hs.612782
SABiosciences Custom PCR Arrays for SPIN4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPIN4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPIN4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPIN4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPIN4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPIN4 |
Orthologs
for SPIN4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SPIN4 gene from 3/9 species (see all 9) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SPIN16 |
-- |
52(a) |
1 → many |
W(144388-156199) |
lizard
(Anolis carolinensis) |
Reptilia |
SPIN16 |
-- |
70(a) |
1 → many |
2(37163227-37172835) |
zebrafish
(Danio rerio) |
Actinopterygii |
CU856539.36 |
-- |
68(a) |
1 → many |
10(2595456-2607514) |
ENSEMBL Gene Tree for SPIN4 (if available)
TreeFam Gene Tree for SPIN4 (if available) |
Paralogs
for SPIN4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SPIN4 gene
- SPIN2B2 SPIN2A2 SPIN12 SPIN32
4 SIMAP similar genes for SPIN4 using alignment to 1 protein entry: SPIN4_HUMAN:SPIN2A SPIN3 SPIN1 SPIN2B
SPIN4 for paralogs About GeneDecksing
|
Genomic Variants
for SPIN4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SPIN4 (62567107 - 62571223 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SPIN4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPIN4 |
|
Disorders
/ Diseases
for SPIN4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SPIN4 for disorders About GeneDecksing
3  diseases for SPIN4: About MalaCardscysticercosis meningoencephalitis eclampsia
2 diseases from the University of Copenhagen DISEASES database for SPIN4:Cysticercosis Eclampsia Export disorders for SPIN4 gene to outside databases
|
Publications
for SPIN4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPIN4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SPIN4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
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External Searches for SPIN4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SPIN4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SPIN4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPIN4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SPIN4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SPIN4 gene:
Search GeneIP for patents involving SPIN4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPIN4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPIN4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPIN4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPIN4 | | | OriGene Protein Over-expression Lysate for SPIN4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPIN4 | | OriGene 3'-UTR Clone for SPIN4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPIN4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPIN4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SPIN4 | | OriGene Custom Protein Services for SPIN4 | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPIN4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPIN4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPIN4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPIN4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPIN4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPIN4 |
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 |  |  |  | |
| | | | Search Tocris compounds for SPIN4 |
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 | | | SPIN4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPIN4 |
|  |  |  | | | | Search ThermoFisher Antibodies for SPIN4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPIN4 |
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