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Aliases for SPIN4 Gene

Aliases for SPIN4 Gene

  • Spindlin Family Member 4 2 3 5
  • Spindlin Family, Member 4 2 3
  • TDRD28 3

External Ids for SPIN4 Gene

Previous GeneCards Identifiers for SPIN4 Gene

  • GC0XM062484
  • GC0XM062568
  • GC0XM056393
  • GC0XM062569

Summaries for SPIN4 Gene

GeneCards Summary for SPIN4 Gene

SPIN4 (Spindlin Family Member 4) is a Protein Coding gene. Diseases associated with SPIN4 include taeniasis. An important paralog of this gene is SPIN2B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPIN4 Gene

Genomics for SPIN4 Gene

Regulatory Elements for SPIN4 Gene

Promoters for SPIN4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SPIN4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPIN4 Gene

Chromosome:
X
Start:
63,347,228 bp from pter
End:
63,351,344 bp from pter
Size:
4,117 bases
Orientation:
Minus strand

Genomic View for SPIN4 Gene

Genes around SPIN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPIN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPIN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPIN4 Gene

Proteins for SPIN4 Gene

  • Protein details for SPIN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q56A73-SPIN4_HUMAN
    Recommended name:
    Spindlin-4
    Protein Accession:
    Q56A73
    Secondary Accessions:
    • B3KX90
    • Q5JUL2

    Protein attributes for SPIN4 Gene

    Size:
    249 amino acids
    Molecular mass:
    28660 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI41371.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SPIN4 Gene

neXtProt entry for SPIN4 Gene

Proteomics data for SPIN4 Gene at MOPED

Post-translational modifications for SPIN4 Gene

  • Ubiquitination at Lys 50
  • Modification sites at PhosphoSitePlus

Other Protein References for SPIN4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPIN4 Gene

Domains & Families for SPIN4 Gene

Gene Families for SPIN4 Gene

Protein Domains for SPIN4 Gene

Suggested Antigen Peptide Sequences for SPIN4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q56A73

UniProtKB/Swiss-Prot:

SPIN4_HUMAN :
  • Belongs to the SPIN/STSY family.
Family:
  • Belongs to the SPIN/STSY family.
genes like me logo Genes that share domains with SPIN4: view

Function for SPIN4 Gene

Phenotypes for SPIN4 Gene

genes like me logo Genes that share phenotypes with SPIN4: view

Animal Model Products

CRISPR Products

miRNA for SPIN4 Gene

miRTarBase miRNAs that target SPIN4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPIN4 Gene

Localization for SPIN4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPIN4 Gene COMPARTMENTS Subcellular localization image for SPIN4 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SPIN4 Gene

Pathways & Interactions for SPIN4 Gene

SuperPathways for SPIN4 Gene

No Data Available

Interacting Proteins for SPIN4 Gene

Gene Ontology (GO) - Biological Process for SPIN4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SPIN4 Gene

Drugs & Compounds for SPIN4 Gene

No Compound Related Data Available

Transcripts for SPIN4 Gene

mRNA/cDNA for SPIN4 Gene

Unigene Clusters for SPIN4 Gene

Spindlin family, member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPIN4 Gene

No ASD Table

Relevant External Links for SPIN4 Gene

GeneLoc Exon Structure for
SPIN4
ECgene alternative splicing isoforms for
SPIN4

Expression for SPIN4 Gene

mRNA expression in normal human tissues for SPIN4 Gene

Protein differential expression in normal tissues from HIPED for SPIN4 Gene

This gene is overexpressed in Urinary Bladder (65.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for SPIN4 Gene



SOURCE GeneReport for Unigene cluster for SPIN4 Gene Hs.612782

genes like me logo Genes that share expression patterns with SPIN4: view

Protein tissue co-expression partners for SPIN4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SPIN4 Gene

Orthologs for SPIN4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPIN4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPIN4 35
  • 99.87 (n)
  • 100 (a)
SPIN4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPIN4 36
  • 99 (a)
OneToOne
SPIN4 35
  • 91.83 (n)
  • 98.8 (a)
dog
(Canis familiaris)
Mammalia SPIN4 35
  • 91.43 (n)
  • 99.2 (a)
SPIN4 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spin4 16
Spin4 36
  • 96 (a)
OneToOne
Spin4 35
  • 88.62 (n)
  • 95.98 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia SPIN4 36
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spin4 35
  • 89.83 (n)
  • 96.39 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01112877.1 36
  • 54 (a)
OneToMany
SPIN4 (2 of 3) 36
  • 52 (a)
OneToMany
SPIN4 (3 of 3) 36
  • 68 (a)
OneToMany
Species with no ortholog for SPIN4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPIN4 Gene

ENSEMBL:
Gene Tree for SPIN4 (if available)
TreeFam:
Gene Tree for SPIN4 (if available)

Paralogs for SPIN4 Gene

Paralogs for SPIN4 Gene

(4) SIMAP similar genes for SPIN4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPIN4: view

Variants for SPIN4 Gene

Sequence variations from dbSNP and Humsavar for SPIN4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs6653244 -- 63,348,645(+) TTATC(A/G)GATTC utr-variant-3-prime
rs34843473 -- 63,352,206(+) TGTCT(-/T)AAACC upstream-variant-2KB
rs73522538 -- 63,348,013(+) TCCCT(A/G)TTAAT utr-variant-3-prime
rs76707308 -- 63,347,851(+) ATCAT(A/C)CAATT utr-variant-3-prime
rs111923761 -- 63,348,588(+) TGAAT(G/T)TCTAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SPIN4 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354

Variation tolerance for SPIN4 Gene

Residual Variation Intolerance Score: 37.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPIN4 Gene

HapMap Linkage Disequilibrium report
SPIN4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPIN4 Gene

Disorders for SPIN4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SPIN4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
taeniasis
  • beef tapeworm infection
- elite association - COSMIC cancer census association via MalaCards
Search SPIN4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SPIN4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPIN4
genes like me logo Genes that share disorders with SPIN4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPIN4 Gene

Publications for SPIN4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for SPIN4 Gene

Sources for SPIN4 Gene

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