Aliases for SPIN4 Gene
Aliases for SPIN4 Gene
External Ids for SPIN4 Gene
- HGNC: 27040
- Entrez Gene: 139886
- Ensembl: ENSG00000186767
- UniProtKB: Q56A73
Previous GeneCards Identifiers for SPIN4 Gene
- GC0XM062484
- GC0XM062568
- GC0XM056393
- GC0XM062569
Summaries for SPIN4 Gene
GeneCards Summary for SPIN4 Gene
SPIN4 (Spindlin Family Member 4) is a Protein Coding gene. An important paralog of this gene is SPIN2A.
UniProtKB/Swiss-Prot for SPIN4 Gene
-
Exhibits H3K4me3-binding activity.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPIN4 Gene
Genomics for SPIN4 Gene
GeneHancer (GH) Regulatory Elements for SPIN4 Gene
Promoters and enhancers for SPIN4 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH0XI063349 | Promoter/Enhancer | 1.9 | EPDnew Ensembl ENCODE | 550.8 | +0.8 | 843 | 3 | PKNOX1 ATF1 FOXA2 MLX SIN3A FEZF1 ZNF48 GLIS2 SP3 SP5 | SPIN4 SPIN4-AS1 GC0XP063338 LINC01278 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around SPIN4 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for SPIN4 Gene
Genomic Locations for SPIN4 Gene
- chrX:63,347,228-63,351,344
- (GRCh38/hg38)
- Size:
- 4,117 bases
- Orientation:
- Minus strand
- chrX:62,567,107-62,571,223
- (GRCh37/hg19)
Genomic View for SPIN4 Gene
Genes around SPIN4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xq11.1 by Ensembl
- Xq11.1 by Entrez Gene
- Xq11.1 by HGNC
SPIN4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)


RefSeq DNA sequence for SPIN4 Gene
Proteins for SPIN4 Gene
-
Protein details for SPIN4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q56A73-SPIN4_HUMAN
- Recommended name:
- Spindlin-4
- Protein Accession:
- Q56A73
- B3KX90
- Q5JUL2
Protein attributes for SPIN4 Gene
- Size:
- 249 amino acids
- Molecular mass:
- 28660 Da
- Quaternary structure:
-
- Interacts with C11orf84/SPINDOC (PubMed:29061846).
- SequenceCaution:
-
- Sequence=CAI41371.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for SPIN4 Gene
Post-translational modifications for SPIN4 Gene
- Ubiquitination at posLast=5050
Other Protein References for SPIN4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for SPIN4
- Novus Biologicals Antibodies for SPIN4
- Invitrogen Antibodies for SPIN4
- Search GeneTex for Antibodies for SPIN4
Protein Products
-
OriGene Purified Proteins for SPIN4
- Search Origene for MassSpec and Protein Over-expression Lysates for SPIN4
- Origene Custom Protein Services for SPIN4
- Search GeneTex for Proteins for SPIN4
Assay Products
No data available for DME Specific Peptides for SPIN4 Gene
Domains & Families for SPIN4 Gene
Gene Families for SPIN4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for SPIN4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SPIN4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q56A73- Family:
-
- Belongs to the SPIN/STSY family.
Function for SPIN4 Gene
Molecular function for SPIN4 Gene
- UniProtKB/Swiss-Prot Function:
- Exhibits H3K4me3-binding activity.
Phenotypes From GWAS Catalog for SPIN4 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 29061846 |
GO:0035064 | methylated histone binding | IDA | 29061846 |
Phenotypes for SPIN4 Gene
- GenomeRNAi human phenotypes for SPIN4:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for SPIN4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SPIN4 gene
- Search ViGene Biosciences for SPIN4
CRISPR Products
-
OriGene CRISPR knockouts for SPIN4
- genomics-online: gRNA clones - Search results for available SPIN4 gene related products
- Applied Biological Materials CRISPR for SPIN4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPIN4
- GenScript: Design CRISPR guide RNA sequences for SPIN4
miRNA for SPIN4 Gene
- miRTarBase miRNAs that target SPIN4
-
- hsa-mir-340-5p (MIRT019605)
- hsa-mir-29c-3p (MIRT020392)
- hsa-mir-192-5p (MIRT026613)
- hsa-mir-96-5p (MIRT027915)
- hsa-mir-24-3p (MIRT030544)
- hsa-mir-889-3p (MIRT244986)
- hsa-mir-4477a (MIRT327713)
- hsa-mir-548aw (MIRT403129)
- hsa-mir-4639-5p (MIRT528231)
- hsa-mir-6790-5p (MIRT528232)
- hsa-mir-4658 (MIRT528233)
- hsa-mir-4758-5p (MIRT528234)
- hsa-mir-1238-5p (MIRT528235)
- hsa-mir-526b-5p (MIRT528236)
- hsa-mir-4795-3p (MIRT528237)
- hsa-mir-1909-5p (MIRT528238)
- hsa-mir-1233-3p (MIRT528239)
- hsa-mir-126-5p (MIRT528240)
- hsa-mir-656-3p (MIRT528241)
- hsa-mir-4687-5p (MIRT528242)
- hsa-mir-4432 (MIRT528243)
- hsa-mir-583 (MIRT528244)
- hsa-mir-1271-5p (MIRT563461)
- hsa-mir-183-5p (MIRT563462)
- hsa-mir-4436b-5p (MIRT563463)
- hsa-mir-95-5p (MIRT563464)
- hsa-mir-4761-5p (MIRT563465)
- hsa-mir-3163 (MIRT563466)
- hsa-mir-5092 (MIRT563467)
- hsa-mir-570-5p (MIRT563468)
- hsa-mir-548ba (MIRT563469)
- hsa-mir-548ai (MIRT563470)
- hsa-mir-548ag (MIRT563471)
- hsa-mir-7844-5p (MIRT563472)
- hsa-mir-4282 (MIRT563473)
- hsa-mir-563 (MIRT692490)
- hsa-mir-380-5p (MIRT692491)
- hsa-mir-758-5p (MIRT692492)
- hsa-mir-532-5p (MIRT692493)
- hsa-mir-651-3p (MIRT692494)
- hsa-mir-522-3p (MIRT692495)
- hsa-mir-224-3p (MIRT692496)
- hsa-mir-129-5p (MIRT692497)
- hsa-mir-3680-3p (MIRT692498)
- hsa-mir-557 (MIRT692499)
- hsa-mir-507 (MIRT692500)
- hsa-mir-450b-5p (MIRT692501)
- hsa-mir-33b-5p (MIRT692502)
- hsa-mir-33a-5p (MIRT692503)
- hsa-mir-527 (MIRT692504)
- hsa-mir-518a-5p (MIRT692505)
- hsa-mir-4684-3p (MIRT692506)
- hsa-mir-656-5p (MIRT692507)
- hsa-mir-138-2-3p (MIRT692508)
miRNA Products
- Search ViGene Biosciences for SPIN4
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SPIN4
- Browse OriGene Inhibitory RNA Products For SPIN4
- genomics-online: shRNA clones - Search results for available SPIN4 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SPIN4 gene
Clone Products
- Sino Biological Human cDNA Clone for SPIN4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for SPIN4
- genomics-online: cdna clones - Search results for available SPIN4 gene related products
- orf clones - Search results for available SPIN4 gene related products
- Applied Biological Materials Clones for SPIN4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for SPIN4
-
ViGene Biosciences adenoviral particle packaged cDNA for SPIN4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SPIN4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SPIN4 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPIN4 Gene
Localization for SPIN4 Gene
- Cytosol (2)
- Nucleoli (2)
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SPIN4 Gene
Pathways & Interactions for SPIN4 Gene
No Data Available
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007276 | gamete generation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for SPIN4 Gene
Transcripts for SPIN4 Gene
mRNA/cDNA for SPIN4 Gene
- (1) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (40) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SPIN4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SPIN4
- genomics-online: gRNA clones - Search results for available SPIN4 gene related products
- Applied Biological Materials CRISPR for SPIN4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPIN4
- GenScript: Design CRISPR guide RNA sequences for SPIN4
miRNA Products
- Search ViGene Biosciences for SPIN4
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SPIN4
- Browse OriGene Inhibitory RNA Products For SPIN4
- genomics-online: shRNA clones - Search results for available SPIN4 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SPIN4 gene
Clone Products
- Sino Biological Human cDNA Clone for SPIN4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for SPIN4
- genomics-online: cdna clones - Search results for available SPIN4 gene related products
- orf clones - Search results for available SPIN4 gene related products
- Applied Biological Materials Clones for SPIN4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for SPIN4 Gene
This gene is overexpressed in Urinary Bladder (65.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SPIN4 Gene
NURSA nuclear receptor signaling pathways regulating expression of SPIN4 Gene:
SPIN4SOURCE GeneReport for Unigene cluster for SPIN4 Gene:
Hs.612782Evidence on tissue expression from TISSUES for SPIN4 Gene
- Nervous system(4.5)
- Blood(3.6)
Primer Products
-
OriGene qPCR primer pairs for SPIN4
- genomics-online: primer clones - Search results for available SPIN4 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPIN4 Gene
Orthologs for SPIN4 Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | SPIN4 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | SPIN4 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | SPIN4 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Spin4 33 |
|
||
mouse (Mus musculus) |
Mammalia | Spin4 33 16 34 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | SPIN4 34 |
|
OneToOne | |
zebrafish (Danio rerio) |
Actinopterygii | SPIN4 (3 of 3) 34 |
|
OneToMany | |
CABZ01112877.1 34 |
|
OneToMany | |||
SPIN4 (2 of 3) 34 |
|
OneToMany |
- Species where no ortholog for SPIN4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for SPIN4 Gene
Variants for SPIN4 Gene
SNP ID | Clin | Chr 0X pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1053713 | -- | 63,347,590(-) | T/C | 3_prime_UTR_variant | |
rs111287985 | -- | 63,347,451(-) | T/C | 3_prime_UTR_variant | |
rs111923761 | -- | 63,348,588(-) | G/T | 3_prime_UTR_variant | |
rs113579085 | -- | 63,352,061(-) | A/G | upstream_transcript_variant | |
rs12859290 | -- | 63,348,659(-) | A/G | 3_prime_UTR_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1584074 | OTHER | inversion | 17803354 |
Residual Variation Intolerance Score:
37.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.08;
1.79% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SPIN4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SPIN4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPIN4 Gene
Disorders for SPIN4 Gene
Additional Disease Information for SPIN4
No disorders were found for SPIN4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPIN4 Gene
Publications for SPIN4 Gene
- A transcriptional coregulator, SPIN·DOC, attenuates the coactivator activity of Spindlin1. (PMID: 29061846) Bae N … Bedford MT (The Journal of biological chemistry 2017) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
- Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A … Hentze MW (Cell 2012) 3 58
Products for SPIN4 Gene
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- Browse Primary Antibodies
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- Custom Antibody ServicesOriGene Antibodies for SPIN4
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- Custom Assay Services
- OriGene Purified Proteins for SPIN4
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- OriGene qPCR primer pairs for SPIN4
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- CloneReady with Over 120,000 Genes
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- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for SPIN4
- Novus Biologicals lysates and proteins for SPIN4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies at Cloud-Clone Corp.
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- Browse Knockouts at Cloud-Clone Corp.
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- Cloud-Clone Corp. disease models service
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- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for SPIN4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for SPIN4
- antibodies-online: Search results for available SPIN4 related products ranked by validation data
- antibodies-online: Search results for available SPIN4 related products ranked by validation data
- antibodies-online: Search results for available SPIN4 related products ranked by validation data
- Search GeneTex for Antibodies for SPIN4
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- ViGene Biosciences adenoviral particle packaged cDNA for SPIN4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for SPIN4 gene
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- Search ViGene Biosciences for SPIN4
- Horizon Cell Lines for SPIN4
- genomics-online: cdna clones - Search results for available SPIN4 gene related products
- orf clones - Search results for available SPIN4 gene related products
- genomics-online: gRNA clones - Search results for available SPIN4 gene related products
- genomics-online: primer clones - Search results for available SPIN4 gene related products
- genomics-online: shRNA clones - Search results for available SPIN4 gene related products
Sources for SPIN4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew