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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SPIN4 Gene

protein-coding GIFtS: 43
GCID: GC0XM062568

Spindlin Family, Member 4

3 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Spindlin Family, Member 4¹ ²
spindlin-4²

External Ids:	HGNC: 27040¹	Entrez Gene: 139886²	Ensembl: ENSG00000186767⁷	UniProtKB: Q56A73³

Export aliases for SPIN4 gene to outside databases

Previous GC identifers: GC0XM062484 GC0XM056393

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SPIN4 Gene:

SPIN4 (spindlin family, member 4) is a protein-coding gene. Diseases associated with SPIN4 include meningoencephalitis, and cysticercosis. An important paralog of this gene is SPIN2B.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.2 NT_011669.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SPIN4 gene promoter:
MAZR ATF-2 MIF-1 Evi-1 E47 HNF-1A NRF-2 HNF-1 ZID NF-kappaB1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for SPIN4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPIN4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq11.1 Ensembl cytogenetic band: Xq11.1 HGNC cytogenetic band: Xq11.1

SPIN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPIN4 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM062568: view genomic region (about GC identifiers)

Start:	62,567,107 bp from pter	End:	62,571,223 bp from pter
Size:	4,117 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SPIN4_HUMAN, Q56A73 (See protein sequence)

Recommended Name: Spindlin-4

Size: 249 amino acids; 28660 Da

Sequence caution: Sequence=CAI41371.1; Type=Erroneous initiation;

Secondary accessions: Q5JUL2

Explore the universe of human proteins at neXtProt for SPIN4: NX_Q56A73

Explore proteomics data for SPIN4 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q56A73

SPIN4 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_001012986.2

ENSEMBL proteins:

ENSP00000364018 ENSP00000334163

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

1 InterPro protein domain:

IPR003671 Spin_Ssty

Graphical View of Domain Structure for InterPro Entry Q56A73

ProtoNet protein and cluster: Q56A73

1 Blocks protein domain: IPB003671 Spindlin/spermiogenesis-specific protein

UniProtKB/Swiss-Prot: SPIN4_HUMAN, Q56A73

Similarity: Belongs to the SPIN/STSY family

SPIN4 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for SPIN4

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SPIN4

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPIN4

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SPIN4

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for SPIN4 (ENSP00000334163⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBC	ENSP00000344818⁴	STRING: ENSP00000344818
ELAVL1	ENSP00000385269⁴	STRING: ENSP00000385269

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007276	gamete generation	IEA	--

SPIN4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SPIN4

Search CenterWatch for drugs/clinical trials and news about SPIN4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SPIN4 gene:

NM_001012968.2

Unigene Cluster for SPIN4:

Spindlin family, member 4

Hs.612782 [show with all ESTs]

Unigene Representative Sequence: AL833314

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000374884 ENST00000335144(uc004dvf.3)

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		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate SPIN4 (see all 10):
		hsa-miR-3163 hsa-miR-576-5p hsa-miR-3673 hsa-miR-513a-3p hsa-miR-548k hsa-miR-3065-5p hsa-miR-33a hsa-miR-9*

		SwitchGear 3'UTR luciferase reporter plasmid: SPIN4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for SPIN4
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPIN4

Additional mRNA sequence:

AK021705.1 AK126931.1 AL833314.1 BC035088.1 BC043412.1 BC112360.1

2 DOTS entries:

DT.108130 DT.100746759

24/40 AceView cDNA sequences (see all 40):

AL833314 BQ424587 BM144682 AK126931 BM667539 AL135659 BC043412 BG059887

BX282201 BU069192 AA598803 BI549232 BC035088 BU688875 BE042498 AI471422

BE042460 AK021705 CB114602 AW582842 BI491676 AA776212 BG178943 CB114607

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SPIN4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AGTGGATTTT

About this image

See SPIN4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPIN4

SOURCE GeneReport for Unigene cluster: Hs.612782

SABiosciences Custom PCR Arrays for SPIN4

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPIN4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for SPIN4 gene from 2/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Spin4^{1 , 5}	spindlin family, member 4^{1, 5}	88.62(n)¹ 95.98(a)¹		X (41.83 cM)⁵ 270624¹ NM_178753.4¹ NP_848868.1¹ 95022510⁵
zebrafish (Danio rerio)	Actinopterygii	SPIN2B⁶ CABZ01112877.1⁶ (see all 3)	Uncharacterized protein (see all 3)	67(a) 53(a) (see all 3)	1 ↔ many possible ortholog (see all 3)	10(2595456-2607514) 2(55803426-55814829)

ENSEMBL Gene Tree for SPIN4 (if available)
TreeFam Gene Tree for SPIN4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SPIN4 gene

SPIN2B² SPIN2A² SPIN1² SPIN3²

4 SIMAP similar genes for SPIN4 using alignment to 1 protein entry: SPIN4_HUMAN:

SPIN2A SPIN3 SPIN1 SPIN2B

SPIN4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs142658517^1,2		--	62566626(+)	`GGAGTA/GGTAAA`	1	--	ds500¹		0	--	--	--	--
rs189648592^1,2		--	62566766(+)	`CATCAC/TTCATG`	1	--	ds500¹		0	--	--	--	--
rs181249499^1,2		--	62567360(+)	`GTCATC/TAGGAT`	1	--	ut3¹		0	--	--	--	--
rs186348587^1,2		--	62567368(+)	`GATTAG/TATTGT`	1	--	ut3¹		0	--	--	--	--
rs150990347^1,2	C	--	62567389(+)	`GTCCTA/GGCTAA`	1	--	ut3¹		0	--	--	--	--
rs189594305^1,2		--	62567552(+)	`TACTTG/TGGAAT`	1	--	ut3¹		0	--	--	--	--
rs139546496^1,2	C	--	62567735(+)	`ACAATC/TTTATC`	1	--	ut3¹		0	--	--	--	--
rs143309680^1,2	C	--	62567877(+)	`AATAGA/GGAATA`	1	--	ut3¹		0	--	--	--	--
rs73522538^1,2	C,F	--	62567892(+)	`TCCCTG/ATTAAT`	1	--	ut3¹		1		WA	2
rs181706942^1,2		--	62567941(+)	`CAGTCA/CCGTCT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SPIN4 (62567107 - 62571223 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for SPIN4: About this table

Variant ID	Type	Subtype	PubMed ID
esv1584074	OTHER	Inversion	17803354

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

3 diseases for SPIN4: About MalaCards

meningoencephalitis cysticercosis eclampsia

2 diseases from the University of Copenhagen DISEASES database for SPIN4:

Cysticercosis Eclampsia

SPIN4 for disorders About GeneDecksing

Export disorders for SPIN4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SPIN4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SPIN4)

Utopia: connect your pdf to the dynamic
world of online information

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)¹ Abdelmohsen K....Gorospe M. (2009)
The DNA sequence of the human X chromosome. (PubMed id 15772651)² Ross M.T.... Bentley D.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
The sequence of the human genome. (PubMed id 11181995)¹ Venter J.C.... Zhu X. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 139886	HGNC: 27040	AceView: LOC139886	Ensembl:ENSG00000186767	euGenes: HUgn139886
ECgene: SPIN4	H-InvDB: SPIN4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SPIN4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SPIN4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SPIN4 gene:
Search GeneIP for patents involving SPIN4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section


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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPIN4

	inGenious Targeting Laboratory - Custom generated mouse model solutions for SPIN4
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Customized:

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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SPIN4 gene at Home site.

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SPIN4 Gene

Spindlin Family, Member 4

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Export list of displayed genes

SPIN4 Gene

Spindlin Family, Member 4

Aliasesfor SPIN4 gene

Summariesfor SPIN4 gene

Genomic Viewsfor SPIN4 gene

Proteinsfor SPIN4 gene

Protein Domains /Familiesfor SPIN4 gene

Functionfor SPIN4 gene

Pathways & Interactionsfor SPIN4 gene

Drugs & Compoundsfor SPIN4 gene

Transcriptsfor SPIN4 gene

Expression for SPIN4 gene

Orthologsfor SPIN4 gene

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Genomic Variantsfor SPIN4 gene

Disorders / Diseasesfor SPIN4 gene

Publicationsfor SPIN4 gene

External Searches for SPIN4 gene

Genome Databases showing SPIN4 gene

Other Databases showing SPIN4 gene

Specialized Databases showing SPIN4 gene

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Productsfor SPIN4 gene

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Aliases
for SPIN4 gene

Summaries
for SPIN4 gene

Genomic Views
for SPIN4 gene

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for SPIN4 gene

Protein Domains /
Families
for SPIN4 gene

Function
for SPIN4 gene

Pathways & Interactions
for SPIN4 gene

Drugs & Compounds
for SPIN4 gene

Transcripts
for SPIN4 gene

Expression
for SPIN4 gene

Orthologs
for SPIN4 gene

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for SPIN4 gene

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for SPIN4 gene

Disorders / Diseases
for SPIN4 gene

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for SPIN4 gene

Intellectual Property
for SPIN4 gene

Products
for SPIN4 gene