Aliases for SPIN4 Gene
External Ids for SPIN4 Gene
- HGNC: 27040
- Entrez Gene: 139886
- Ensembl: ENSG00000186767
- UniProtKB: Q56A73
Previous GeneCards Identifiers for SPIN4 Gene
- GC0XM062484
- GC0XM062568
- GC0XM056393
- GC0XM062569
Summaries for SPIN4 Gene
GeneCards Summary for SPIN4 Gene
SPIN4 (Spindlin Family Member 4) is a Protein Coding gene. Diseases associated with SPIN4 include Taeniasis. An important paralog of this gene is SPIN2B.
No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPIN4 Gene
Genomics for SPIN4 Gene
Regulatory Elements for SPIN4 Gene
Enhancers for SPIN4 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around SPIN4 on UCSC Golden Path with GeneCards custom track
Promoters for SPIN4 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around SPIN4 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the SPIN4 gene promoter:
Regulatory Element Products
Genomic Location for SPIN4 Gene
- Chromosome:
- X
- Start:
- 63,347,228 bp from pter
- End:
- 63,351,344 bp from pter
- Size:
- 4,117 bases
- Orientation:
- Minus strand
Genomic View for SPIN4 Gene
Genes around SPIN4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xq11.1 by Ensembl
- Xq11.1 by Entrez Gene
- Xq11.1 by HGNC
SPIN4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SPIN4 Gene
Proteins for SPIN4 Gene
-
Protein details for SPIN4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q56A73-SPIN4_HUMAN
- Recommended name:
- Spindlin-4
- Protein Accession:
- Q56A73
- B3KX90
- Q5JUL2
Protein attributes for SPIN4 Gene
- Size:
- 249 amino acids
- Molecular mass:
- 28660 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=CAI41371.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for SPIN4 Gene
Post-translational modifications for SPIN4 Gene
Other Protein References for SPIN4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for SPIN4
- Novus Biologicals Antibodies for SPIN4
- Abcam antibodies for SPIN4
- Search GeneTex for Antibodies for SPIN4
-
Santa Cruz Biotechnology (SCBT) Antibodies for SPIN4
Protein Products
-
OriGene Purified Proteins for SPIN4
- Search Origene for MassSpec and Protein Over-expression Lysates for SPIN4
- Origene Custom Protein Services for SPIN4
- Search GeneTex for Proteins for SPIN4
Assay Products
No data available for DME Specific Peptides for SPIN4 Gene
Domains & Families for SPIN4 Gene
Gene Families for SPIN4 Gene
Protein Domains for SPIN4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SPIN4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q56A73- Family:
-
- Belongs to the SPIN/STSY family.
Function for SPIN4 Gene
Phenotypes for SPIN4 Gene
- GenomeRNAi human phenotypes for SPIN4:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for SPIN4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SPIN4 gene
- Search ViGene Biosciences for SPIN4
CRISPR Products
-
OriGene CRISPR knockouts for SPIN4
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPIN4
- GenScript: Design CRISPR guide RNA sequences for SPIN4
miRNA for SPIN4 Gene
- miRTarBase miRNAs that target SPIN4
-
- hsa-mir-340-5p (MIRT019605)
- hsa-mir-29c-3p (MIRT020392)
- hsa-mir-192-5p (MIRT026613)
- hsa-mir-96-5p (MIRT027915)
- hsa-mir-24-3p (MIRT030544)
- hsa-mir-889-3p (MIRT244986)
- hsa-mir-4477a (MIRT327713)
- hsa-mir-548aw (MIRT403129)
- hsa-mir-4639-5p (MIRT528231)
- hsa-mir-6790-5p (MIRT528232)
- hsa-mir-4658 (MIRT528233)
- hsa-mir-4758-5p (MIRT528234)
- hsa-mir-1238-5p (MIRT528235)
- hsa-mir-526b-5p (MIRT528236)
- hsa-mir-4795-3p (MIRT528237)
- hsa-mir-1909-5p (MIRT528238)
- hsa-mir-1233-3p (MIRT528239)
- hsa-mir-126-5p (MIRT528240)
- hsa-mir-656-3p (MIRT528241)
- hsa-mir-4687-5p (MIRT528242)
- hsa-mir-4432 (MIRT528243)
- hsa-mir-583 (MIRT528244)
- hsa-mir-1271-5p (MIRT563461)
- hsa-mir-183-5p (MIRT563462)
- hsa-mir-4436b-5p (MIRT563463)
- hsa-mir-95-5p (MIRT563464)
- hsa-mir-4761-5p (MIRT563465)
- hsa-mir-3163 (MIRT563466)
- hsa-mir-5092 (MIRT563467)
- hsa-mir-570-5p (MIRT563468)
- hsa-mir-548ba (MIRT563469)
- hsa-mir-548ai (MIRT563470)
- hsa-mir-548ag (MIRT563471)
- hsa-mir-7844-5p (MIRT563472)
- hsa-mir-4282 (MIRT563473)
- hsa-mir-563 (MIRT692490)
- hsa-mir-380-5p (MIRT692491)
- hsa-mir-758-5p (MIRT692492)
- hsa-mir-532-5p (MIRT692493)
- hsa-mir-651-3p (MIRT692494)
- hsa-mir-522-3p (MIRT692495)
- hsa-mir-224-3p (MIRT692496)
- hsa-mir-129-5p (MIRT692497)
- hsa-mir-3680-3p (MIRT692498)
- hsa-mir-557 (MIRT692499)
- hsa-mir-507 (MIRT692500)
- hsa-mir-450b-5p (MIRT692501)
- hsa-mir-33b-5p (MIRT692502)
- hsa-mir-33a-5p (MIRT692503)
- hsa-mir-527 (MIRT692504)
- hsa-mir-518a-5p (MIRT692505)
- hsa-mir-4684-3p (MIRT692506)
- hsa-mir-656-5p (MIRT692507)
- hsa-mir-138-2-3p (MIRT692508)
miRNA Products
- Search ViGene Biosciences for SPIN4
Inhibitory RNA Products
- Origene RNAi, shRNA, mouse_rna, and siRNA products in human, mouse, rat for SPIN4
- Browse OriGene Inhibitory RNA Products For SPIN4
-
ViGene Biosciences ready-to-package AAV shRNAs for SPIN4 gene
Clone Products
- OriGene clones in human for SPIN4
- OriGene ORF clones in human,mouse for SPIN4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for SPIN4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SPIN4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SPIN4 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPIN4 Gene
Localization for SPIN4 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| cytosol | 2 |
| mitochondrion | 2 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SPIN4 Gene
More details on SuperPathways for SPIN4Transcripts for SPIN4 Gene
mRNA/cDNA for SPIN4 Gene
- (1) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (40) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SPIN4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SPIN4
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPIN4
- GenScript: Design CRISPR guide RNA sequences for SPIN4
miRNA Products
- Search ViGene Biosciences for SPIN4
Inhibitory RNA Products
- Origene RNAi, shRNA, mouse_rna, and siRNA products in human, mouse, rat for SPIN4
- Browse OriGene Inhibitory RNA Products For SPIN4
-
ViGene Biosciences ready-to-package AAV shRNAs for SPIN4 gene
Clone Products
- OriGene clones in human for SPIN4
- OriGene ORF clones in human,mouse for SPIN4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for SPIN4 Gene
This gene is overexpressed in Urinary Bladder (65.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for SPIN4 Gene
SOURCE GeneReport for Unigene cluster for SPIN4 Gene Hs.612782
Primer Products
-
OriGene qPCR primer pairs for SPIN4
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SPIN4 Gene
Orthologs for SPIN4 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | SPIN4 35 |
|
||
| SPIN4 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | SPIN4 35 |
|
||
| SPIN4 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Spin4 35 |
|
||
| Spin4 16 |
|
||||
| Spin4 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | SPIN4 35 |
|
||
| SPIN4 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Spin4 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | SPIN4 36 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | CABZ01112877.1 36 |
|
OneToMany | |
| SPIN4 (2 of 3) 36 |
|
OneToMany | |||
| SPIN4 (3 of 3) 36 |
|
OneToMany |
- Species with no ortholog for SPIN4:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for SPIN4 Gene
(4) SIMAP similar genes for SPIN4 Gene using alignment to 1 proteins:
Variants for SPIN4 Gene
| SNP ID | Clin | Chr 0X pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1053713 | -- | 63,347,590(-) | TATGA(A/G)TATGT | utr-variant-3-prime | |
| rs2872320 | -- | 63,352,205(-) | ATTGT(A/C/G/T)TAAAC | upstream-variant-2KB | |
| rs6624337 | -- | 63,346,890(+) | CATTC(A/G)TGGGG | downstream-variant-500B | |
| rs6653244 | -- | 63,348,645(+) | TTATC(A/G)GATTC | utr-variant-3-prime | |
| rs12859290 | -- | 63,348,659(+) | AACTT(A/G)CGATG | utr-variant-3-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1584074 | OTHER | Inversion | 17803354 |
Residual Variation Intolerance Score:
37.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.08;
1.79% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SPIN4 Gene
Disorders for SPIN4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| taeniasis |
|
|
Search SPIN4 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for SPIN4
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- SPIN4
No data available for UniProtKB/Swiss-Prot and Genatlas for SPIN4 Gene
Publications for SPIN4 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
- Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
Products for SPIN4 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Custom Antibody ServicesOriGene Antibodies for SPIN4
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for SPIN4
- Search Origene for MassSpec and Protein Over-expression Lysates for SPIN4
- Origene Custom Protein Services for SPIN4
- Origene siRNA, shRNA, mouse_rna, and RNAi products in human, mouse, rat for SPIN4
- Browse OriGene Inhibitory RNA Products For SPIN4
- OriGene qPCR primer pairs for SPIN4
- OriGene CRISPR knockouts for SPIN4
- OriGene clones in human for SPIN4
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for SPIN4
- GenScript Custom Assay Services for SPIN4
- GenScript Custom overexpressing Cell Line Services for SPIN4
- GenScript: Design CRISPR guide RNA sequences for SPIN4
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for SPIN4
- Novus Biologicals Antibodies for SPIN4
- Novus Biologicals proteins and lysates for SPIN4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ViGene Biosciences adenoviral particle packaged cDNA for SPIN4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for SPIN4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for SPIN4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SPIN4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SPIN4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SPIN4 gene
- Search ViGene Biosciences for SPIN4
- Search ViGene Biosciences for SPIN4
- Santa Cruz Biotechnology (SCBT) Antibodies for SPIN4
- Search Santa Cruz Biotechnology (SCBT) for SPIN4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SPIN4
Sources for SPIN4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon