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Aliases for SPIN4 Gene

Aliases for SPIN4 Gene

  • Spindlin Family Member 4 2 3 5
  • Spindlin Family, Member 4 2
  • Spindlin-4 3
  • TDRD28 3

External Ids for SPIN4 Gene

Previous GeneCards Identifiers for SPIN4 Gene

  • GC0XM062484
  • GC0XM062568
  • GC0XM056393
  • GC0XM062569

Summaries for SPIN4 Gene

GeneCards Summary for SPIN4 Gene

SPIN4 (Spindlin Family Member 4) is a Protein Coding gene. An important paralog of this gene is SPIN1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPIN4 Gene

Genomics for SPIN4 Gene

Regulatory Elements for SPIN4 Gene

Enhancers for SPIN4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF063350 0.9 ENCODE 0.8 +0.3 292 1.9 ELF3 TBP HDAC1 CBX3 PKNOX1 MLX ZNF48 RAD21 GLIS2 GATA2 SPIN4 SPIN4-AS1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SPIN4 on UCSC Golden Path with GeneCards custom track

Promoters for SPIN4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001490138 1043 3399 ELF3 TBP HDAC1 CBX3 PKNOX1 MLX FEZF1 ZNF48 RAD21 GLIS2

Genomic Location for SPIN4 Gene

63,347,228 bp from pter
63,351,344 bp from pter
4,117 bases
Minus strand

Genomic View for SPIN4 Gene

Genes around SPIN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPIN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPIN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPIN4 Gene

Proteins for SPIN4 Gene

  • Protein details for SPIN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B3KX90
    • Q5JUL2

    Protein attributes for SPIN4 Gene

    249 amino acids
    Molecular mass:
    28660 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAI41371.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SPIN4 Gene

neXtProt entry for SPIN4 Gene

Post-translational modifications for SPIN4 Gene

  • Ubiquitination at Lys 50
  • Modification sites at PhosphoSitePlus

Other Protein References for SPIN4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPIN4 Gene

Domains & Families for SPIN4 Gene

Gene Families for SPIN4 Gene

Protein Domains for SPIN4 Gene

Suggested Antigen Peptide Sequences for SPIN4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPIN/STSY family.
  • Belongs to the SPIN/STSY family.
genes like me logo Genes that share domains with SPIN4: view

Function for SPIN4 Gene

Phenotypes for SPIN4 Gene

genes like me logo Genes that share phenotypes with SPIN4: view

Animal Model Products

miRNA for SPIN4 Gene

miRTarBase miRNAs that target SPIN4

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SPIN4

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPIN4 Gene

Localization for SPIN4 Gene

Subcellular locations from

Jensen Localization Image for SPIN4 Gene COMPARTMENTS Subcellular localization image for SPIN4 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SPIN4 Gene

Pathways & Interactions for SPIN4 Gene

SuperPathways for SPIN4 Gene

No Data Available

Interacting Proteins for SPIN4 Gene

Gene Ontology (GO) - Biological Process for SPIN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007276 gamete generation IEA --
genes like me logo Genes that share ontologies with SPIN4: view

No data available for Pathways by source and SIGNOR curated interactions for SPIN4 Gene

Transcripts for SPIN4 Gene

mRNA/cDNA for SPIN4 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(40) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPIN4 Gene

Spindlin family, member 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SPIN4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPIN4 Gene

No ASD Table

Relevant External Links for SPIN4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPIN4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPIN4 Gene

Protein differential expression in normal tissues from HIPED for SPIN4 Gene

This gene is overexpressed in Urinary Bladder (65.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SPIN4 Gene

Protein tissue co-expression partners for SPIN4 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPIN4 Gene:


SOURCE GeneReport for Unigene cluster for SPIN4 Gene:

genes like me logo Genes that share expression patterns with SPIN4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SPIN4 Gene

Orthologs for SPIN4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPIN4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPIN4 34 35
  • 99.87 (n)
(Bos Taurus)
Mammalia SPIN4 34 35
  • 91.83 (n)
(Canis familiaris)
Mammalia SPIN4 34 35
  • 91.43 (n)
(Rattus norvegicus)
Mammalia Spin4 34
  • 89.83 (n)
(Mus musculus)
Mammalia Spin4 34 16 35
  • 88.62 (n)
(Ornithorhynchus anatinus)
Mammalia SPIN4 35
  • 55 (a)
(Danio rerio)
Actinopterygii SPIN4 (3 of 3) 35
  • 68 (a)
CABZ01112877.1 35
  • 54 (a)
SPIN4 (2 of 3) 35
  • 52 (a)
Species where no ortholog for SPIN4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPIN4 Gene

Gene Tree for SPIN4 (if available)
Gene Tree for SPIN4 (if available)

Paralogs for SPIN4 Gene

Paralogs for SPIN4 Gene

(4) SIMAP similar genes for SPIN4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPIN4: view

Variants for SPIN4 Gene

Sequence variations from dbSNP and Humsavar for SPIN4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1053713 -- 63,347,590(-) TATGA(A/G)TATGT utr-variant-3-prime
rs111287985 -- 63,347,451(+) AAAGC(C/T)GATTA utr-variant-3-prime
rs111923761 -- 63,348,588(+) TGAAT(G/T)TCTAG utr-variant-3-prime
rs113579085 -- 63,352,061(+) CCAAG(A/G)TTGTT upstream-variant-2KB
rs12859290 -- 63,348,659(+) AACTT(A/G)CGATG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SPIN4 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER inversion 17803354

Variation tolerance for SPIN4 Gene

Residual Variation Intolerance Score: 37.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPIN4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPIN4 Gene

Disorders for SPIN4 Gene

Relevant External Links for SPIN4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SPIN4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPIN4 Gene

Publications for SPIN4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3 64
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64

Products for SPIN4 Gene

Sources for SPIN4 Gene

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