Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SPIN4 Gene

Aliases for SPIN4 Gene

  • Spindlin Family, Member 4 2 3
  • Spindlin-4 3

External Ids for SPIN4 Gene

Previous GeneCards Identifiers for SPIN4 Gene

  • GC0XM062484
  • GC0XM062568
  • GC0XM056393
  • GC0XM062569

Summaries for SPIN4 Gene

GeneCards Summary for SPIN4 Gene

SPIN4 (Spindlin Family, Member 4) is a Protein Coding gene. Diseases associated with SPIN4 include cysticercosis. An important paralog of this gene is SPIN2B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPIN4 Gene

Genomics for SPIN4 Gene

Regulatory Elements for SPIN4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SPIN4 Gene

63,347,228 bp from pter
63,351,344 bp from pter
4,117 bases
Minus strand

Genomic View for SPIN4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPIN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPIN4 Gene

Proteins for SPIN4 Gene

  • Protein details for SPIN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B3KX90
    • Q5JUL2

    Protein attributes for SPIN4 Gene

    249 amino acids
    Molecular mass:
    28660 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAI41371.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SPIN4 Gene

neXtProt entry for SPIN4 Gene

Proteomics data for SPIN4 Gene at MOPED

Post-translational modifications for SPIN4 Gene

  • Ubiquitination at Lys50
  • Modification sites at PhosphoSitePlus

Other Protein References for SPIN4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SPIN4

No data available for DME Specific Peptides for SPIN4 Gene

Domains for SPIN4 Gene

Gene Families for SPIN4 Gene

Protein Domains for SPIN4 Gene

Suggested Antigen Peptide Sequences for SPIN4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPIN/STSY family.
  • Belongs to the SPIN/STSY family.
genes like me logo Genes that share domains with SPIN4: view

Function for SPIN4 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for SPIN4 Gene

Localization for SPIN4 Gene

Subcellular locations from

Jensen Localization Image for SPIN4 Gene COMPARTMENTS Subcellular localization image for SPIN4 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SPIN4 Gene

Pathways for SPIN4 Gene

SuperPathways for SPIN4 Gene

No Data Available

Interacting Proteins for SPIN4 Gene

Gene Ontology (GO) - Biological Process for SPIN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007276 gamete generation IEA --
genes like me logo Genes that share ontologies with SPIN4: view

No data available for Pathways by source for SPIN4 Gene

Transcripts for SPIN4 Gene

mRNA/cDNA for SPIN4 Gene

Unigene Clusters for SPIN4 Gene

Spindlin family, member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPIN4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPIN4 Gene

No ASD Table

Relevant External Links for SPIN4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPIN4 Gene

mRNA expression in normal human tissues for SPIN4 Gene

Protein differential expression in normal tissues for SPIN4 Gene

This gene is overexpressed in Urinary Bladder (65.3).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SPIN4 Gene

SOURCE GeneReport for Unigene cluster for SPIN4 Gene Hs.612782

genes like me logo Genes that share expressions with SPIN4: view

Expression partners for SPIN4 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SPIN4 Gene

Orthologs for SPIN4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPIN4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SPIN4 35
  • 91.83 (n)
  • 98.8 (a)
SPIN4 36
  • 99 (a)
(Canis familiaris)
Mammalia SPIN4 35
  • 91.43 (n)
  • 99.2 (a)
SPIN4 36
  • 99 (a)
(Mus musculus)
Mammalia Spin4 35
  • 88.62 (n)
  • 95.98 (a)
Spin4 16
Spin4 36
  • 96 (a)
(Pan troglodytes)
Mammalia SPIN4 35
  • 99.87 (n)
  • 100 (a)
SPIN4 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Spin4 35
  • 89.83 (n)
  • 96.39 (a)
(Ornithorhynchus anatinus)
Mammalia SPIN4 36
  • 55 (a)
(Danio rerio)
Actinopterygii CABZ01112877.1 36
  • 54 (a)
SPIN4 (2 of 3) 36
  • 52 (a)
SPIN4 (3 of 3) 36
  • 68 (a)
Species with no ortholog for SPIN4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPIN4 Gene

Gene Tree for SPIN4 (if available)
Gene Tree for SPIN4 (if available)

Paralogs for SPIN4 Gene

Paralogs for SPIN4 Gene

(4) SIMAP similar genes for SPIN4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPIN4: view

Variants for SPIN4 Gene

Sequence variations from dbSNP and Humsavar for SPIN4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1053713 -- 63,347,590(-) TATGA(A/G)TATGT utr-variant-3-prime
rs2872320 -- 63,352,205(+) ATTGT(C/G/T)TAAAC upstream-variant-2KB
rs6624337 -- 63,346,890(+) CATTC(A/G)TGGGG downstream-variant-500B
rs6653244 -- 63,348,645(+) TTATC(A/G)GATTC utr-variant-3-prime
rs12859290 -- 63,348,659(+) AACTT(A/G)CGATG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SPIN4 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354

Relevant External Links for SPIN4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPIN4 Gene

Disorders for SPIN4 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SPIN4 Gene in MalaCards »

(1) Disease for SPIN4 Gene

(2) University of Copenhagen DISEASES for SPIN4 Gene

genes like me logo Genes that share disorders with SPIN4: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for SPIN4 Gene

Publications for SPIN4 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for SPIN4 Gene

Sources for SPIN4 Gene

Back to Top