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Aliases for SPIN3 Gene

Aliases for SPIN3 Gene

  • Spindlin Family Member 3 2 3 5
  • Spindlin Family, Member 3 2 3
  • Spindlin-Like Protein 3 3 4
  • SPIN-3 3 4
  • BA445O16.1 (DXF34) 3
  • BA445O16.1 3
  • TDRD27 3

External Ids for SPIN3 Gene

Previous GeneCards Identifiers for SPIN3 Gene

  • GC0XM056903
  • GC0XM054066

Summaries for SPIN3 Gene

GeneCards Summary for SPIN3 Gene

SPIN3 (Spindlin Family Member 3) is a Protein Coding gene. An important paralog of this gene is SPIN2B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPIN3 Gene

Genomics for SPIN3 Gene

Regulatory Elements for SPIN3 Gene

Enhancers for SPIN3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SPIN3 on UCSC Golden Path with GeneCards custom track

Promoters for SPIN3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SPIN3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPIN3 Gene

Chromosome:
X
Start:
56,976,370 bp from pter
End:
56,995,601 bp from pter
Size:
19,232 bases
Orientation:
Minus strand

Genomic View for SPIN3 Gene

Genes around SPIN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPIN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPIN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPIN3 Gene

Proteins for SPIN3 Gene

  • Protein details for SPIN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JUX0-SPIN3_HUMAN
    Recommended name:
    Spindlin-3
    Protein Accession:
    Q5JUX0
    Secondary Accessions:
    • B2RUW3
    • B7Z8W2
    • Q8N5D9

    Protein attributes for SPIN3 Gene

    Size:
    258 amino acids
    Molecular mass:
    29207 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SPIN3 Gene

    Alternative splice isoforms for SPIN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPIN3 Gene

Proteomics data for SPIN3 Gene at MOPED

Post-translational modifications for SPIN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPIN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPIN3 Gene

Domains & Families for SPIN3 Gene

Gene Families for SPIN3 Gene

Protein Domains for SPIN3 Gene

Suggested Antigen Peptide Sequences for SPIN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5JUX0

UniProtKB/Swiss-Prot:

SPIN3_HUMAN :
  • Belongs to the SPIN/STSY family.
Family:
  • Belongs to the SPIN/STSY family.
genes like me logo Genes that share domains with SPIN3: view

Function for SPIN3 Gene

Phenotypes for SPIN3 Gene

GenomeRNAi human phenotypes for SPIN3:
genes like me logo Genes that share phenotypes with SPIN3: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPIN3 Gene

Localization for SPIN3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPIN3 Gene COMPARTMENTS Subcellular localization image for SPIN3 gene
Compartment Confidence
mitochondrion 3
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SPIN3 Gene

Pathways & Interactions for SPIN3 Gene

SuperPathways for SPIN3 Gene

No Data Available

Interacting Proteins for SPIN3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000364054%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000376609%0d%0a
Selected Interacting proteins: ENSP00000364054 Q5JUX0-SPIN3_HUMAN for SPIN3 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SPIN3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SPIN3 Gene

Drugs & Compounds for SPIN3 Gene

No Compound Related Data Available

Transcripts for SPIN3 Gene

Unigene Clusters for SPIN3 Gene

Spindlin family, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPIN3 Gene

No ASD Table

Relevant External Links for SPIN3 Gene

GeneLoc Exon Structure for
SPIN3
ECgene alternative splicing isoforms for
SPIN3

Expression for SPIN3 Gene

mRNA expression in normal human tissues for SPIN3 Gene

Protein differential expression in normal tissues from HIPED for SPIN3 Gene

This gene is overexpressed in Fetal testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPIN3 Gene



SOURCE GeneReport for Unigene cluster for SPIN3 Gene Hs.522672

genes like me logo Genes that share expression patterns with SPIN3: view

Protein tissue co-expression partners for SPIN3 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SPIN3 Gene

Orthologs for SPIN3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPIN3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SPIN3 35
  • 92.25 (n)
  • 89.06 (a)
SPIN2 36
  • 70 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia SPIN3 35
  • 99.74 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia SPIN3 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 84 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm21637 36
  • 56 (a)
ManyToMany
chicken
(Gallus gallus)
Aves SPINW 36
  • 75 (a)
ManyToMany
SPINZ 36
  • 83 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 84 (a)
OneToMany
Species with no ortholog for SPIN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPIN3 Gene

ENSEMBL:
Gene Tree for SPIN3 (if available)
TreeFam:
Gene Tree for SPIN3 (if available)

Paralogs for SPIN3 Gene

Paralogs for SPIN3 Gene

(4) SIMAP similar genes for SPIN3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPIN3: view

Variants for SPIN3 Gene

Sequence variations from dbSNP and Humsavar for SPIN3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs747752481 -- 56,988,014(+) TAAAG(A/C)GTGTT intron-variant
rs747907440 -- 56,997,026(+) TGTTG(A/G)AGAGA upstream-variant-2KB
rs748007573 -- 56,987,068(+) GGAGG(G/T)TGCGG intron-variant
rs748389847 -- 56,990,577(+) AATAT(A/G)TAATT intron-variant, downstream-variant-500B
rs748472846 -- 56,995,698(+) AGAAG(C/T)TGTGG upstream-variant-2KB

Variation tolerance for SPIN3 Gene

Residual Variation Intolerance Score: 36.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.20% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for SPIN3 Gene

Disorders for SPIN3 Gene

Relevant External Links for SPIN3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPIN3

No disorders were found for SPIN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPIN3 Gene

Publications for SPIN3 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PMID: 22952844) Wu Z. … Ma L. (PLoS ONE 2012) 3
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for SPIN3 Gene

Sources for SPIN3 Gene

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