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Aliases for SPIN2B Gene

Aliases for SPIN2B Gene

  • Spindlin Family Member 2B 2 3 5
  • Spindlin-Like Protein 2B 3 4
  • SPIN-2B 3 4
  • SPIN-2 3 4
  • Spindlin Family, Member 2 Duplicate 3
  • Spindlin Family, Member 2B 2
  • Telomeric SPIN2 Copy 3
  • SPIN2_duplicate 3
  • Spindlin-2B 3
  • DJ323P24.2 3
  • TDRD26 3
  • SPIN2 4

External Ids for SPIN2B Gene

Previous GeneCards Identifiers for SPIN2B Gene

  • GC0XM057163
  • GC0XM054209

Summaries for SPIN2B Gene

GeneCards Summary for SPIN2B Gene

SPIN2B (Spindlin Family Member 2B) is a Protein Coding gene. An important paralog of this gene is SPIN2A.

UniProtKB/Swiss-Prot for SPIN2B Gene

  • Involved in the regulation of cell cycle progression, this activity is related to the inhibition of apoptosis following the removal of essential growth factors.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPIN2B Gene

Genomics for SPIN2B Gene

Regulatory Elements for SPIN2B Gene

Enhancers for SPIN2B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF056780 1.2 Ensembl ENCODE 21.4 +339.0 339031 3.2 SCRT1 CTCF RAD21 YY1 CTBP1 ZNF512 MLLT1 PRDM1 SPI1 SPIN2B MTHFD1P1 UBQLN2 UQCRBP1 ENSG00000224799
GH0XF056761 0.9 Ensembl ENCODE 21.4 +356.2 356155 7.6 HDGF TBP PKNOX1 TBL1XR1 YBX1 FEZF1 RAD21 YY1 ZNF121 ETV6 SPIN2B MTHFD1P1 UQCRBP1 ENSG00000224799
GH0XF056811 0.6 Ensembl ENCODE 20.4 +308.2 308222 3.1 HDGF TBP PKNOX1 IRF2 MXI1 MAX ZFHX2 GATA3 CTBP1 FOS SPIN2B UQCRBP1 ENSG00000224799
GH0XF056802 1.1 Ensembl ENCODE 20.4 +318.1 318135 2.0 CTCF PKNOX1 MAZ TBL1XR1 WRNIP1 ZNF384 REST RAD21 YY1 SMC3 SPIN2B SPIN3 UQCRBP1 ENSG00000224799
GH0XF056787 1 Ensembl ENCODE 20.1 +332.9 332884 1.9 CTCF ZNF680 ZNF512 SMC3 RAD21 YY1 SPIN2B MTHFD1P1 UQCRBP1 ENSG00000224799
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SPIN2B on UCSC Golden Path with GeneCards custom track

Promoters for SPIN2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SPIN2B Gene

57,118,551 bp from pter
57,121,556 bp from pter
3,006 bases
Minus strand

Genomic View for SPIN2B Gene

Genes around SPIN2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPIN2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPIN2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPIN2B Gene

Proteins for SPIN2B Gene

  • Protein details for SPIN2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q7Z2M0

    Protein attributes for SPIN2B Gene

    258 amino acids
    Molecular mass:
    29158 Da
    Quaternary structure:
    No Data Available
    • Overexpression in murine myeloid cell line 32Dcl3 causes G2/M arrest.

neXtProt entry for SPIN2B Gene

Post-translational modifications for SPIN2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SPIN2B Gene

Domains & Families for SPIN2B Gene

Gene Families for SPIN2B Gene

Protein Domains for SPIN2B Gene

Suggested Antigen Peptide Sequences for SPIN2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPIN/STSY family.
  • Belongs to the SPIN/STSY family.
genes like me logo Genes that share domains with SPIN2B: view

Function for SPIN2B Gene

Molecular function for SPIN2B Gene

UniProtKB/Swiss-Prot Function:
Involved in the regulation of cell cycle progression, this activity is related to the inhibition of apoptosis following the removal of essential growth factors.

Phenotypes for SPIN2B Gene

GenomeRNAi human phenotypes for SPIN2B:
genes like me logo Genes that share phenotypes with SPIN2B: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPIN2B Gene

Localization for SPIN2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPIN2B Gene

Subcellular locations from

Jensen Localization Image for SPIN2B Gene COMPARTMENTS Subcellular localization image for SPIN2B gene
Compartment Confidence
nucleus 4
cytosol 2
peroxisome 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SPIN2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SPIN2B: view

Pathways & Interactions for SPIN2B Gene

SuperPathways for SPIN2B Gene

No Data Available

Interacting Proteins for SPIN2B Gene

Gene Ontology (GO) - Biological Process for SPIN2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007049 cell cycle IEA --
GO:0007276 gamete generation IEA --
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with SPIN2B: view

No data available for Pathways by source and SIGNOR curated interactions for SPIN2B Gene

Transcripts for SPIN2B Gene

mRNA/cDNA for SPIN2B Gene

(11) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPIN2B Gene

Spindlin family, member 2B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPIN2B Gene

No ASD Table

Relevant External Links for SPIN2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPIN2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPIN2B Gene

Protein differential expression in normal tissues from HIPED for SPIN2B Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPIN2B Gene

Protein tissue co-expression partners for SPIN2B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SPIN2B Gene:


SOURCE GeneReport for Unigene cluster for SPIN2B Gene:


mRNA Expression by UniProt/SwissProt for SPIN2B Gene:

Tissue specificity: Detected in all the examined tissues with highest expression in liver, followed by heart, stomach, kidney, skeletal muscle, placenta, and pancreas.
genes like me logo Genes that share expression patterns with SPIN2B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SPIN2B Gene

Orthologs for SPIN2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPIN2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPIN2A 34
  • 99.1 (n)
(Canis familiaris)
Mammalia -- 35
  • 97 (a)
(Bos Taurus)
Mammalia -- 35
  • 95 (a)
  • 87.86 (n)
-- 35
  • 85 (a)
(Mus musculus)
Mammalia Spin2c 35
  • 82 (a)
Gm3757 34
  • 73.15 (n)
Spin2-ps4 16
(Rattus norvegicus)
Mammalia LOC367746 34
  • 81.87 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 78 (a)
(Gallus gallus)
Aves SPINZ 35
  • 77 (a)
  • 70 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 77 (a)
Species where no ortholog for SPIN2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPIN2B Gene

Gene Tree for SPIN2B (if available)
Gene Tree for SPIN2B (if available)

Paralogs for SPIN2B Gene

Paralogs for SPIN2B Gene

(4) SIMAP similar genes for SPIN2B Gene using alignment to 4 proteins: Pseudogenes for SPIN2B Gene

genes like me logo Genes that share paralogs with SPIN2B: view

Variants for SPIN2B Gene

Sequence variations from dbSNP and Humsavar for SPIN2B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs112880667 -- 57,123,539(+) GGTCA(A/G)ATGGT intron-variant, upstream-variant-2KB
rs112982350 -- 57,118,452(+) TTTTG(G/T)GGGTT intron-variant
rs138021440 -- 57,116,339(+) TGCAT(A/G)TGGAA intron-variant
rs138711429 -- 57,112,456(+) CTTAC(A/T)ATTCA nc-transcript-variant
rs138951579 -- 57,113,463(+) AGCAG(C/T)ACTAT intron-variant

Variation tolerance for SPIN2B Gene

Residual Variation Intolerance Score: 58.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.01; 0.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPIN2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SPIN2B Gene

Disorders for SPIN2B Gene

Relevant External Links for SPIN2B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SPIN2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPIN2B Gene

Publications for SPIN2B Gene

  1. Functional cloning of SPIN-2, a nuclear anti-apoptotic protein with roles in cell cycle progression. (PMID: 12145692) Fletcher B.S. … Nolan G.P. (Leukemia 2002) 2 3 4 64
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Blocking the Wnt pathway, a unifying mechanism for an angiogenic inhibitor in the serine proteinase inhibitor family. (PMID: 20351274) Zhang B. … Ma J.X. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 64

Products for SPIN2B Gene

Sources for SPIN2B Gene

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