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Aliases for SPIN2B Gene

Aliases for SPIN2B Gene

  • Spindlin Family, Member 2B 2 3
  • Spindlin-Like Protein 2B 3 4
  • SPIN-2B 3 4
  • SPIN-2 3 4
  • SPIN2 4 6
  • Spindlin Family, Member 2 Duplicate 3
  • Telomeric SPIN2 Copy 3
  • SPIN2_duplicate 3
  • Spindlin-2B 3
  • DJ323P24.2 3

External Ids for SPIN2B Gene

Summaries for SPIN2B Gene

GeneCards Summary for SPIN2B Gene

SPIN2B (Spindlin Family, Member 2B) is a Protein Coding gene. An important paralog of this gene is SPIN3.

UniProtKB/Swiss-Prot for SPIN2B Gene

  • Involved in the regulation of cell cycle progression, this activity is related to the inhibition of apoptosis following the removal of essential growth factors.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPIN2B Gene

Genomics for SPIN2B Gene

Genomic Location for SPIN2B Gene

Start:
57,118,551 bp from pter
End:
57,121,556 bp from pter
Size:
3,006 bases
Orientation:
Minus strand

Genomic View for SPIN2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPIN2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPIN2B Gene

Regulatory Elements for SPIN2B Gene

Proteins for SPIN2B Gene

  • Protein details for SPIN2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BPZ2-SPI2B_HUMAN
    Recommended name:
    Spindlin-2B
    Protein Accession:
    Q9BPZ2
    Secondary Accessions:
    • Q7Z2M0

    Protein attributes for SPIN2B Gene

    Size:
    258 amino acids
    Molecular mass:
    29158 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Overexpression in murine myeloid cell line 32Dcl3 causes G2/M arrest

neXtProt entry for SPIN2B Gene

Proteomics data for SPIN2B Gene at MOPED

Post-translational modifications for SPIN2B Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys108

No data available for DME Specific Peptides for SPIN2B Gene

Domains for SPIN2B Gene

Protein Domains for SPIN2B Gene

UniProtKB/Swiss-Prot:

SPI2B_HUMAN
Family:
  • Belongs to the SPIN/STSY family.:
    • Q9BPZ2
genes like me logo Genes that share domains with SPIN2B: view

No data available for Gene Families for SPIN2B Gene

Function for SPIN2B Gene

Molecular function for SPIN2B Gene

UniProtKB/Swiss-Prot Function: Involved in the regulation of cell cycle progression, this activity is related to the inhibition of apoptosis following the removal of essential growth factors.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SPIN2B Gene

Localization for SPIN2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPIN2B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPIN2B Gene COMPARTMENTS Subcellular localization image for SPIN2B gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SPIN2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SPIN2B: view

Pathways for SPIN2B Gene

SuperPathways for SPIN2B Gene

No Data Available

Interacting Proteins for SPIN2B Gene

Gene Ontology (GO) - Biological Process for SPIN2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007049 cell cycle IEA --
GO:0007276 gamete generation IEA --
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with SPIN2B: view

No data available for Pathways by source for SPIN2B Gene

Transcripts for SPIN2B Gene

mRNA/cDNA for SPIN2B Gene

(11) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPIN2B Gene

Spindlin family, member 2B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPIN2B Gene

No ASD Table

Relevant External Links for SPIN2B Gene

GeneLoc Exon Structure for
SPIN2B
ECgene alternative splicing isoforms for
SPIN2B

Expression for SPIN2B Gene

mRNA expression in normal human tissues for SPIN2B Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SPIN2B Gene

SOURCE GeneReport for Unigene cluster for SPIN2B Gene Hs.745094

mRNA Expression by UniProt/SwissProt for SPIN2B Gene

Q9BPZ2-SPI2B_HUMAN
Tissue specificity: Detected in all the examined tissues with highest expression in liver, followed by heart, stomach, kidney, skeletal muscle, placenta, and pancreas
genes like me logo Genes that share expressions with SPIN2B: view

Orthologs for SPIN2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPIN2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPIN2A 36
  • 99.1 (n)
  • 98.45 (a)
cow
(Bos Taurus)
Mammalia -- 37
  • 95 (a)
ManyToMany
-- 37
  • 85 (a)
ManyToMany
SPIN2B 36
  • 87.86 (n)
  • 85.27 (a)
dog
(Canis familiaris)
Mammalia -- 37
  • 97 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm3757 36
  • 73.15 (n)
  • 65.61 (a)
Spin2c 37
  • 82 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 78 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC367746 36
  • 81.87 (n)
  • 78.8 (a)
chicken
(Gallus gallus)
Aves SPINW 37
  • 70 (a)
ManyToMany
SPINZ 37
  • 77 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 77 (a)
OneToMany
Species with no ortholog for SPIN2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPIN2B Gene

ENSEMBL:
Gene Tree for SPIN2B (if available)
TreeFam:
Gene Tree for SPIN2B (if available)

Paralogs for SPIN2B Gene

Paralogs for SPIN2B Gene

Selected SIMAP similar genes for SPIN2B Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for SPIN2B Gene

genes like me logo Genes that share paralogs with SPIN2B: view

Variants for SPIN2B Gene

Sequence variations from dbSNP and Humsavar for SPIN2B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs364007 -- 57,119,772(+) TTTCA(A/G)TACAC utr-variant-3-prime
rs409085 -- 57,119,563(+) TCAAT(G/T)TATTC downstream-variant-500B
rs432644 -- 57,121,450(+) CCCCA(A/C/G/T)CGCTT utr-variant-5-prime, upstream-variant-2KB
rs436217 -- 57,119,210(-) GTTCC(A/C)TAGAA downstream-variant-500B
rs707345 -- 57,119,602(-) CAGCT(A/G)TCAGA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SPIN2B Gene

Variant ID Type Subtype PubMed ID
nsv483129 CNV Loss 15286789

Relevant External Links for SPIN2B Gene

HapMap Linkage Disequilibrium report
SPIN2B

Disorders for SPIN2B Gene

No disorders were found for SPIN2B Gene.

No data available for UniProtKB/Swiss-Prot for SPIN2B Gene

Publications for SPIN2B Gene

  1. Functional cloning of SPIN-2, a nuclear anti-apoptotic protein with roles in cell cycle progression. (PMID: 12145692) Fletcher B.S. … Nolan G.P. (Leukemia 2002) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Blocking the Wnt pathway, a unifying mechanism for an angiogenic inhibitor in the serine proteinase inhibitor family. (PMID: 20351274) Zhang B. … Ma J.X. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3

Products for SPIN2B Gene

Sources for SPIN2B Gene

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