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Aliases for SPIN2B Gene

Aliases for SPIN2B Gene

  • Spindlin Family, Member 2B 2 3
  • Spindlin-Like Protein 2B 3 4
  • SPIN-2B 3 4
  • SPIN-2 3 4
  • SPIN2 4 6
  • Spindlin Family, Member 2 Duplicate 3
  • Telomeric SPIN2 Copy 3
  • SPIN2_duplicate 3
  • Spindlin-2B 3
  • DJ323P24.2 3

External Ids for SPIN2B Gene

Previous GeneCards Identifiers for SPIN2B Gene

  • GC0XM057163
  • GC0XM054209

Summaries for SPIN2B Gene

GeneCards Summary for SPIN2B Gene

SPIN2B (Spindlin Family, Member 2B) is a Protein Coding gene. An important paralog of this gene is SPIN3.

UniProtKB/Swiss-Prot for SPIN2B Gene

  • Involved in the regulation of cell cycle progression, this activity is related to the inhibition of apoptosis following the removal of essential growth factors.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPIN2B Gene

Genomics for SPIN2B Gene

Regulatory Elements for SPIN2B Gene

Genomic Location for SPIN2B Gene

57,118,551 bp from pter
57,121,556 bp from pter
3,006 bases
Minus strand

Genomic View for SPIN2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPIN2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPIN2B Gene

Proteins for SPIN2B Gene

  • Protein details for SPIN2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q7Z2M0

    Protein attributes for SPIN2B Gene

    258 amino acids
    Molecular mass:
    29158 Da
    Quaternary structure:
    No Data Available
    • Overexpression in murine myeloid cell line 32Dcl3 causes G2/M arrest

neXtProt entry for SPIN2B Gene

Proteomics data for SPIN2B Gene at MOPED

Post-translational modifications for SPIN2B Gene

  • Ubiquitination at Lys108
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SPIN2B

No data available for DME Specific Peptides for SPIN2B Gene

Domains for SPIN2B Gene

Gene Families for SPIN2B Gene

Protein Domains for SPIN2B Gene

Suggested Antigen Peptide Sequences for SPIN2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPIN/STSY family.
  • Belongs to the SPIN/STSY family.
genes like me logo Genes that share domains with SPIN2B: view

Function for SPIN2B Gene

Molecular function for SPIN2B Gene

UniProtKB/Swiss-Prot Function:
Involved in the regulation of cell cycle progression, this activity is related to the inhibition of apoptosis following the removal of essential growth factors.

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SPIN2B Gene

Localization for SPIN2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPIN2B Gene

Subcellular locations from

Jensen Localization Image for SPIN2B Gene COMPARTMENTS Subcellular localization image for SPIN2B gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SPIN2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SPIN2B: view

Pathways for SPIN2B Gene

SuperPathways for SPIN2B Gene

No Data Available

Interacting Proteins for SPIN2B Gene

Gene Ontology (GO) - Biological Process for SPIN2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007049 cell cycle IEA --
GO:0007276 gamete generation IEA --
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with SPIN2B: view

No data available for Pathways by source for SPIN2B Gene

Transcripts for SPIN2B Gene

mRNA/cDNA for SPIN2B Gene

(11) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPIN2B Gene

Spindlin family, member 2B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPIN2B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPIN2B Gene

No ASD Table

Relevant External Links for SPIN2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPIN2B Gene

mRNA expression in normal human tissues for SPIN2B Gene

Protein differential expression in normal tissues for SPIN2B Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SPIN2B Gene

SOURCE GeneReport for Unigene cluster for SPIN2B Gene Hs.745094

mRNA Expression by UniProt/SwissProt for SPIN2B Gene

Tissue specificity: Detected in all the examined tissues with highest expression in liver, followed by heart, stomach, kidney, skeletal muscle, placenta, and pancreas
genes like me logo Genes that share expressions with SPIN2B: view

Expression partners for SPIN2B Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SPIN2B Gene

Orthologs for SPIN2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPIN2B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SPIN2B 35
  • 87.86 (n)
  • 85.27 (a)
-- 36
  • 95 (a)
-- 36
  • 85 (a)
(Mus musculus)
Mammalia Gm3757 35
  • 73.15 (n)
  • 65.61 (a)
Spin2c 36
  • 82 (a)
(Pan troglodytes)
Mammalia SPIN2A 35
  • 99.1 (n)
  • 98.45 (a)
(Rattus norvegicus)
Mammalia LOC367746 35
  • 81.87 (n)
  • 78.8 (a)
(Canis familiaris)
Mammalia -- 36
  • 97 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 78 (a)
(Gallus gallus)
Aves SPINW 36
  • 70 (a)
  • 77 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 77 (a)
Species with no ortholog for SPIN2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPIN2B Gene

Gene Tree for SPIN2B (if available)
Gene Tree for SPIN2B (if available)

Paralogs for SPIN2B Gene

Paralogs for SPIN2B Gene

(4) SIMAP similar genes for SPIN2B Gene using alignment to 4 proteins: Pseudogenes for SPIN2B Gene

genes like me logo Genes that share paralogs with SPIN2B: view

Variants for SPIN2B Gene

Sequence variations from dbSNP and Humsavar for SPIN2B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs364007 -- 57,119,772(+) TTTCA(A/G)TACAC utr-variant-3-prime
rs409085 -- 57,119,563(+) TCAAT(G/T)TATTC downstream-variant-500B
rs432644 -- 57,121,450(+) CCCCA(A/C/G/T)CGCTT utr-variant-5-prime, upstream-variant-2KB
rs436217 -- 57,119,210(-) GTTCC(A/C)TAGAA downstream-variant-500B
rs707345 -- 57,119,602(-) CAGCT(A/G)TCAGA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SPIN2B Gene

Variant ID Type Subtype PubMed ID
nsv483129 CNV Loss 15286789

Relevant External Links for SPIN2B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPIN2B Gene

Disorders for SPIN2B Gene

No disorders were found for SPIN2B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for SPIN2B Gene

Publications for SPIN2B Gene

  1. Functional cloning of SPIN-2, a nuclear anti-apoptotic protein with roles in cell cycle progression. (PMID: 12145692) Fletcher B.S. … Nolan G.P. (Leukemia 2002) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Blocking the Wnt pathway, a unifying mechanism for an angiogenic inhibitor in the serine proteinase inhibitor family. (PMID: 20351274) Zhang B. … Ma J.X. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3

Products for SPIN2B Gene

Sources for SPIN2B Gene

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