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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPIN2B Gene

protein-coding   GIFtS: 40
GCID: GC0XM057163

spindlin family, member 2B
  Search for SPIN2B
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SPIN2B    

Aliases
for SPIN2B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Spindlin Family, Member 2B1 2     DJ323P24.21
SPIN-21 2 3     Spindlin Family, Member 2 Duplicate2
Spindlin-Like Protein 2B2 3     Spindlin-2B1
SPIN-2B2 3     Telomeric SPIN2 Copy2
SPIN2_duplicate2     SPIN23

External Ids:    HGNC: 331471   Entrez Gene: 4743432   Ensembl: ENSG000001867877   OMIM: 3005175   UniProtKB: Q9BPZ23   

Export aliases for SPIN2B gene to outside databases

Previous GC identifer: GC0XM054209


Summaries
for SPIN2B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: SPI2B_HUMAN, Q9BPZ2
Function: Involved in the regulation of cell cycle progression, this activity is related to the inhibition of apoptosis
following the removal of essential growth factors




Genomic Views
for SPIN2B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011630.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPIN2B gene promoter:
         GR   SRF   HOXA3   SRF (504 AA)   GR-beta   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SPIN2B promoter sequence
   Search SABiosciences Chromatin IP Primers for SPIN2B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPIN2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.1   Ensembl cytogenetic band:  Xp11.21   HGNC cytogenetic band: Xp11.1

SPIN2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPIN2B gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM057163:  view genomic region     (about GC identifiers)

Start:
 57,144,984 bp from pter      End:
 57,147,980 bp from pter
Size:
 2,997 bases      Orientation:
 minus strand

Proteins
for SPIN2B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SPI2B_HUMAN, Q9BPZ2 (See protein sequence)
Recommended Name: Spindlin-2B  
Size: 258 amino acids; 29158 Da
Subcellular location: Nucleus
Miscellaneous: Overexpression in murine myeloid cell line 32Dcl3 causes G2/M arrest
Secondary accessions: Q7Z2M0

Explore the universe of human proteins at neXtProt for SPIN2B: NX_Q9BPZ2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BPZ2

    • SPIN2B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001006682.1  NP_001006683.1  NP_001006684.1  

    ENSEMBL proteins: 
     ENSP00000275988   ENSP00000364047   ENSP00000364045   ENSP00000404314   ENSP00000335008  

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    Uscn Proteins for SPIN2B

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    SPIN2B for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for SPIN2B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SPIN2B for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR003671 Spin_Ssty

    Graphical View of Domain Structure for InterPro Entry Q9BPZ2

    ProtoNet protein and cluster: Q9BPZ2

    1 Blocks protein family: IPB003671 Spindlin/spermiogenesis-specific protein

    UniProtKB/Swiss-Prot: SPI2B_HUMAN, Q9BPZ2
    Similarity: Belongs to the SPIN/STSY family


    Function
    for SPIN2B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SPI2B_HUMAN, Q9BPZ2
    Function: Involved in the regulation of cell cycle progression, this activity is related to the inhibition of apoptosis
    following the removal of essential growth factors

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Pathways & Interactions
    for SPIN2B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPIN2B

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0007049cell cycle IEA--
    GO:0007276gamete generation IEA--


    SPIN2B for ontologies           About GeneDecksing



    Drugs & Compounds
    for SPIN2B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPIN2B
    Search CenterWatch for drugs/clinical trials and news about SPIN2B / SPI2B 

    Transcripts
    for SPIN2B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section
    REFSEQ mRNAs for SPIN2B gene (3 alternative transcripts): 
    NM_001006681.1  NM_001006682.1  NM_001006683.1  

    Unigene Cluster for SPIN2B:

    Spindlin family, member 2B
    Hs.460717  [show with all ESTs]
    Unigene Representative Sequence: NM_001006681
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000460948 ENST00000275988 ENST00000374912(uc004duy.3 uc004duz.3)
    ENST00000374910 ENST00000434397 ENST00000333933(uc004dva.3)

    miRNA
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    hsa-miR-3618 hsa-miR-934 hsa-miR-1283 hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmid: SPIN2B 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF356353.1 AK311172.1 BC000044.2 BC071974.1 

    5 DOTS entries:

    DT.100755466  DT.310824  DT.95259847  DT.92013557  DT.100803394 

    GeneLoc Exon Structure


    Expression
    for SPIN2B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPIN2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SPIN2B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor W8 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SPIN2B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPIN2B

    SOURCE GeneReport for Unigene cluster: Hs.460717

    UniProtKB/Swiss-Prot: SPI2B_HUMAN, Q9BPZ2
    Tissue specificity: Detected in all the examined tissues with highest expression in liver, followed by heart, stomach,
    kidney, skeletal muscle, placenta, and pancreas

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPIN2B

    Orthologs
    for SPIN2B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for SPIN2B gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SPIN16
    		 --
    		 57(a)
    		 1 → many
    		 W(144388-156199)
    lizard
    (Anolis carolinensis)    		 Reptilia SPIN16
    		 --
    		 78(a)
    		 1 → many
    		 2(37163227-37172835)
    zebrafish
    (Danio rerio)    		 Actinopterygii CU856539.36
    		 --
    		 74(a)
    		 1 → many
    		 10(2595456-2607514)


    ENSEMBL Gene Tree for SPIN2B (if available)
    TreeFam Gene Tree for SPIN2B (if available) 

    Paralogs
    for SPIN2B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPIN2B gene
    SPIN2A1 2  SPIN12  SPIN42  SPIN32  
    4 SIMAP similar genes for SPIN2B using alignment to 4 protein entries:     SPI2B_HUMAN (see all proteins):
    SPIN2A    SPIN3    SPIN1    SPIN4

    SPIN2B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SPIN2B
    PGOHUM00000241343


    Genomic Variants
    for SPIN2B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/33 NCBI SNPs in SPIN2B are shown (see all 33)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1873983091,2
    		--57145627(+) CCTTGC/TCAGAA 3 -- ds50010--------
    rs4362171,2
    		C,H--57145643(-) GTTCCC/ATAGAA 3 -- ds50015Minor allele frequency- A:0.00NS EA NA 422
    rs4090851,2
    		H--57145996(+) TCAATT/GTATTC 3 -- ds50014Minor allele frequency- G:0.00NS EA 418
    rs1478507091,2
    		--57146032(+) CTCTCC/TGATAG 3 -- ds50010--------
    rs7073451,2
    		C,F,H,--57146035(-) CAGCTA/GTCAGA 3 -- ds500114Minor allele frequency- G:0.04NS EA WA NA CSA 433
    rs17368641,2
    		--57146122(-) TGTGTA/GTACAT 3 -- ut31 ese30--------
    rs17368631,2
    		C,--57146123(-) TTGTGA/TGTACA 3 -- ut31 ese30--------
    rs17368621,2
    		--57146129(-) ACAAAC/TTTGTG 3 -- ut31 ese33Minor allele frequency- T:0.05MN NA 188
    rs3640071,2
    		--57146205(+) TTTCAA/GTACAC 3 -- ut315Minor allele frequency- G:0.00NA EA 256
    rs734946401,2
    		--57147733(+) CGCTGC/TTGCCT 3 -- ut510--------

    HapMap Linkage Disequilibrium report for SPIN2B (57144984 - 57147980 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SPIN2B
         1 CNV: 0243

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    Disorders / Diseases
    for SPIN2B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SPIN2B for disorders           About MalaCards

    SPIN2B for disorders           About GeneDecksing

    OMIM gene information: 300517    OMIM disorders: --


    Export disorders for SPIN2B gene to outside databases

    Publications
    for SPIN2B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPIN2B gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SPIN2B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional cloning of SPIN-2, a nuclear anti-apoptotic protein with roles in cell cycle progression. (PubMed id 12145692)1, 2, 3 Fletcher B.S.... Nolan G.P. (2002)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Blocking the Wnt pathway, a unifying mechanism for an angiogenic inhibitor in the serine proteinase inhibitor family. (PubMed id 20351274)1 Zhang B....Ma J.X. (2010)
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for SPIN2B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SPIN2B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 474343 HGNC: 33147 Ensembl:ENSG00000186787 euGenes: HUgn474343 ECgene: SPIN2B
    H-InvDB: SPIN2B

    Other Databases showing SPIN2B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SPIN2B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPIN2B Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SPIN2B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SPIN2B gene:
    Search GeneIP for patents involving SPIN2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SPIN2B gene

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    About This Section

     
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    VWF
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    von Willebrand factor
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