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Aliases for SPIN2B Gene

Aliases for SPIN2B Gene

  • Spindlin Family Member 2B 2 3 5
  • Spindlin-Like Protein 2B 3 4
  • SPIN-2B 3 4
  • SPIN-2 3 4
  • Spindlin Family, Member 2 Duplicate 3
  • Spindlin Family, Member 2B 2
  • Telomeric SPIN2 Copy 3
  • SPIN2_duplicate 3
  • Spindlin-2B 3
  • DJ323P24.2 3
  • TDRD26 3
  • SPIN2 4

External Ids for SPIN2B Gene

Previous GeneCards Identifiers for SPIN2B Gene

  • GC0XM057163
  • GC0XM054209

Summaries for SPIN2B Gene

GeneCards Summary for SPIN2B Gene

SPIN2B (Spindlin Family Member 2B) is a Protein Coding gene. An important paralog of this gene is SPIN2A.

UniProtKB/Swiss-Prot for SPIN2B Gene

  • Involved in the regulation of cell cycle progression, this activity is related to the inhibition of apoptosis following the removal of essential growth factors (PubMed:12145692). Exhibits H3K4me3-binding activity (PubMed:29061846).

Additional gene information for SPIN2B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPIN2B Gene

Genomics for SPIN2B Gene

GeneHancer (GH) Regulatory Elements for SPIN2B Gene

Promoters and enhancers for SPIN2B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI057120 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 575.7 +0.1 55 2.2 HDGF ATF1 ARID4B SIN3A ZNF2 YY1 POLR2B GLIS2 ZNF207 ATF7 SPIN2B ENSG00000226310 FAAH2 MTHFD1P1 PIR45844
GH0XI056562 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 17 +556.6 556562 4.8 HDGF PKNOX1 ATF1 ARNT ARID4B SIN3A DMAP1 ZNF48 YY1 POLR2B UBQLN2 SPIN2B ENSG00000230105
GH0XI056761 Enhancer 1.3 Ensembl ENCODE dbSUPER 21.4 +356.2 356165 7.2 HDGF PKNOX1 FOXA2 ZSCAN4 FEZF1 YBX1 BATF IRF4 RAD21 YY1 SPIN2B MTHFD1P1 UQCRBP1 NBDY ENSG00000224799
GH0XI056728 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE 17.3 +391.7 391655 2.6 HDGF PKNOX1 SIN3A ZNF335 POLR3A EGR1 ZNF366 ZSCAN5C ZNF143 ATF7 NBDY SPIN2B MTHFD1P1 UBQLN2 ENSG00000226310 GC0XP056733
GH0XI056811 Enhancer 1.1 Ensembl ENCODE dbSUPER 20.4 +308.2 308222 3.1 HDGF PKNOX1 IRF2 MAX ZFHX2 CTBP1 GATA3 POLR2A FOS RUNX3 SPIN2B UQCRBP1 NBDY ENSG00000224799
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPIN2B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPIN2B gene promoter:

Genomic Locations for SPIN2B Gene

Genomic Locations for SPIN2B Gene
chrX:57,118,551-57,121,556
(GRCh38/hg38)
Size:
3,006 bases
Orientation:
Minus strand
chrX:57,144,984-57,147,980
(GRCh37/hg19)

Genomic View for SPIN2B Gene

Genes around SPIN2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPIN2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPIN2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPIN2B Gene

Proteins for SPIN2B Gene

  • Protein details for SPIN2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BPZ2-SPI2B_HUMAN
    Recommended name:
    Spindlin-2B
    Protein Accession:
    Q9BPZ2
    Secondary Accessions:
    • Q7Z2M0

    Protein attributes for SPIN2B Gene

    Size:
    258 amino acids
    Molecular mass:
    29158 Da
    Quaternary structure:
    • Interacts with C11orf84/SPINDOC (PubMed:29061846).
    Miscellaneous:
    • Overexpression in murine myeloid cell line 32Dcl3 causes G2/M arrest.

neXtProt entry for SPIN2B Gene

Post-translational modifications for SPIN2B Gene

No Post-translational modifications

No data available for DME Specific Peptides for SPIN2B Gene

Domains & Families for SPIN2B Gene

Gene Families for SPIN2B Gene

Protein Domains for SPIN2B Gene

Suggested Antigen Peptide Sequences for SPIN2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BPZ2

UniProtKB/Swiss-Prot:

SPI2B_HUMAN :
  • Belongs to the SPIN/STSY family.
Family:
  • Belongs to the SPIN/STSY family.
genes like me logo Genes that share domains with SPIN2B: view

Function for SPIN2B Gene

Molecular function for SPIN2B Gene

UniProtKB/Swiss-Prot Function:
Involved in the regulation of cell cycle progression, this activity is related to the inhibition of apoptosis following the removal of essential growth factors (PubMed:12145692). Exhibits H3K4me3-binding activity (PubMed:29061846).

Gene Ontology (GO) - Molecular Function for SPIN2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 29061846
GO:0035064 methylated histone binding IDA 29061846
genes like me logo Genes that share ontologies with SPIN2B: view

Phenotypes for SPIN2B Gene

GenomeRNAi human phenotypes for SPIN2B:
genes like me logo Genes that share phenotypes with SPIN2B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPIN2B Gene

Localization for SPIN2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPIN2B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPIN2B gene
Compartment Confidence
nucleus 5
cytosol 5
peroxisome 2
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SPIN2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with SPIN2B: view

Pathways & Interactions for SPIN2B Gene

SuperPathways for SPIN2B Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPIN2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007049 cell cycle IEA --
GO:0007276 gamete generation IEA --
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with SPIN2B: view

No data available for Pathways by source and SIGNOR curated interactions for SPIN2B Gene

Drugs & Compounds for SPIN2B Gene

No Compound Related Data Available

Transcripts for SPIN2B Gene

mRNA/cDNA for SPIN2B Gene

(11) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPIN2B Gene

Spindlin family, member 2B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPIN2B Gene

No ASD Table

Relevant External Links for SPIN2B Gene

GeneLoc Exon Structure for
SPIN2B
ECgene alternative splicing isoforms for
SPIN2B

Expression for SPIN2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPIN2B Gene

Protein differential expression in normal tissues from HIPED for SPIN2B Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPIN2B Gene



Protein tissue co-expression partners for SPIN2B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SPIN2B Gene:

SPIN2B

SOURCE GeneReport for Unigene cluster for SPIN2B Gene:

Hs.745094

mRNA Expression by UniProt/SwissProt for SPIN2B Gene:

Q9BPZ2-SPI2B_HUMAN
Tissue specificity: Detected in all the examined tissues with highest expression in liver, followed by heart, stomach, kidney, skeletal muscle, placenta, and pancreas.
genes like me logo Genes that share expression patterns with SPIN2B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPIN2B Gene

Orthologs for SPIN2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPIN2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPIN2A 33
  • 99.1 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 97 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 95 (a)
ManyToMany
SPIN2B 33
  • 87.86 (n)
-- 34
  • 85 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Spin2c 34
  • 82 (a)
ManyToMany
Gm3757 33
  • 73.15 (n)
Spin2-ps4 16
rat
(Rattus norvegicus)
Mammalia LOC367746 33
  • 81.87 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 78 (a)
OneToMany
chicken
(Gallus gallus)
Aves SPINZ 34
  • 77 (a)
ManyToMany
SPINW 34
  • 70 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 77 (a)
OneToMany
Species where no ortholog for SPIN2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPIN2B Gene

ENSEMBL:
Gene Tree for SPIN2B (if available)
TreeFam:
Gene Tree for SPIN2B (if available)

Paralogs for SPIN2B Gene

Paralogs for SPIN2B Gene

(4) SIMAP similar genes for SPIN2B Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for SPIN2B Gene

genes like me logo Genes that share paralogs with SPIN2B: view

Variants for SPIN2B Gene

Sequence variations from dbSNP and Humsavar for SPIN2B Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000255672 -- 57,114,083(-) /T genic_downstream_transcript_variant, intron_variant
rs1000574954 -- 57,116,506(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000606061 -- 57,116,222(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000667621 -- 57,121,046(-) T/C intron_variant
rs1001205815 -- 57,121,486(-) G/C 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant

Variation tolerance for SPIN2B Gene

Residual Variation Intolerance Score: 58.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.01; 0.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPIN2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPIN2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SPIN2B Gene

Disorders for SPIN2B Gene

Additional Disease Information for SPIN2B

No disorders were found for SPIN2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPIN2B Gene

Publications for SPIN2B Gene

  1. Functional cloning of SPIN-2, a nuclear anti-apoptotic protein with roles in cell cycle progression. (PMID: 12145692) Fletcher BS … Nolan GP (Leukemia 2002) 2 3 4 58
  2. A transcriptional coregulator, SPIN·DOC, attenuates the coactivator activity of Spindlin1. (PMID: 29061846) Bae N … Bedford MT (The Journal of biological chemistry 2017) 3 4 58
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for SPIN2B Gene

Sources for SPIN2B Gene

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