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Aliases for SPIN2A Gene

Aliases for SPIN2A Gene

  • Spindlin Family Member 2A 2 3 5
  • Spindlin Family, Member 2A 2 3
  • Spindlin-Like Protein 2A 3 4
  • SPIN2 3 4
  • DXF34 3 4
  • Spindlin Family, Member 2 2
  • Spindlin-Like Protein 2 3
  • Centromeric Spin2 Copy 3
  • Spindlin Homolog 2 3
  • Protein DXF34 4
  • DJ323P24.1 3
  • SPIN-2A 4
  • TDRD25 3
  • SPIN-2 4

External Ids for SPIN2A Gene

Previous HGNC Symbols for SPIN2A Gene

  • SPIN2

Previous GeneCards Identifiers for SPIN2A Gene

  • GC0XM057178
  • GC0XM054225

Summaries for SPIN2A Gene

Entrez Gene Summary for SPIN2A Gene

  • This gene encodes one of three members of the DXF34 gene family, located in a 100-kb region of chromosome Xp11.21. [provided by RefSeq, Nov 2009]

GeneCards Summary for SPIN2A Gene

SPIN2A (Spindlin Family Member 2A) is a Protein Coding gene. An important paralog of this gene is SPIN2B.

UniProtKB/Swiss-Prot for SPIN2A Gene

  • May be involved in the regulation of cell cycle progression.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPIN2A Gene

Genomics for SPIN2A Gene

Regulatory Elements for SPIN2A Gene

Enhancers for SPIN2A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SPIN2A on UCSC Golden Path with GeneCards custom track

Promoters for SPIN2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SPIN2A on UCSC Golden Path with GeneCards custom track

Genomic Location for SPIN2A Gene

57,134,530 bp from pter
57,137,644 bp from pter
3,115 bases
Minus strand

Genomic View for SPIN2A Gene

Genes around SPIN2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPIN2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPIN2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPIN2A Gene

Proteins for SPIN2A Gene

  • Protein details for SPIN2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • O75650
    • Q6IPW2
    • Q9UJJ0

    Protein attributes for SPIN2A Gene

    258 amino acids
    Molecular mass:
    29188 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAA70988.1; Type=Frameshift; Positions=10; Evidence={ECO:0000305};

neXtProt entry for SPIN2A Gene

Proteomics data for SPIN2A Gene at MOPED

Post-translational modifications for SPIN2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPIN2A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPIN2A Gene

Domains & Families for SPIN2A Gene

Gene Families for SPIN2A Gene

Protein Domains for SPIN2A Gene

Suggested Antigen Peptide Sequences for SPIN2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPIN/STSY family.
  • Belongs to the SPIN/STSY family.
genes like me logo Genes that share domains with SPIN2A: view

Function for SPIN2A Gene

Molecular function for SPIN2A Gene

UniProtKB/Swiss-Prot Function:
May be involved in the regulation of cell cycle progression.
genes like me logo Genes that share phenotypes with SPIN2A: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPIN2A Gene

Localization for SPIN2A Gene

Subcellular locations from

Jensen Localization Image for SPIN2A Gene COMPARTMENTS Subcellular localization image for SPIN2A gene
Compartment Confidence
nucleus 3
cytosol 2
peroxisome 2
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SPIN2A Gene

Pathways & Interactions for SPIN2A Gene

SuperPathways for SPIN2A Gene

No Data Available

Interacting Proteins for SPIN2A Gene

Gene Ontology (GO) - Biological Process for SPIN2A Gene


No data available for Pathways by source and SIGNOR curated interactions for SPIN2A Gene

Drugs & Compounds for SPIN2A Gene

No Compound Related Data Available

Transcripts for SPIN2A Gene

mRNA/cDNA for SPIN2A Gene

(6) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPIN2A Gene

Spindlin family, member 2A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPIN2A Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3a · 3b · 3c
SP1: - - - -
SP2: -
SP3: - -
SP4: - -

Relevant External Links for SPIN2A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPIN2A Gene

mRNA expression in normal human tissues for SPIN2A Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPIN2A Gene

SOURCE GeneReport for Unigene cluster for SPIN2A Gene Hs.460725

genes like me logo Genes that share expression patterns with SPIN2A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SPIN2A Gene

Orthologs for SPIN2A Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPIN2A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SPIN2B 35
  • 87.6 (n)
  • 84.88 (a)
-- 36
  • 95 (a)
-- 36
  • 85 (a)
(Mus musculus)
Mammalia Gm3757 35
  • 73.15 (n)
  • 66.06 (a)
Gm2854 36
  • 64 (a)
Gm5926 36
  • 62 (a)
Spin2-ps5 36
  • 62 (a)
Spin2-ps6 36
  • 61 (a)
Spin2d 36
  • 64 (a)
Spin2e 36
  • 63 (a)
Spin2f 36
  • 61 (a)
(Pan troglodytes)
Mammalia SPIN2A 35
  • 99.35 (n)
  • 98.84 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC367746 35
  • 81.6 (n)
  • 78.4 (a)
(Canis familiaris)
Mammalia -- 36
  • 97 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 77 (a)
(Gallus gallus)
Aves SPINW 36
  • 70 (a)
  • 77 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 77 (a)
Species with no ortholog for SPIN2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPIN2A Gene

Gene Tree for SPIN2A (if available)
Gene Tree for SPIN2A (if available)

Paralogs for SPIN2A Gene

Paralogs for SPIN2A Gene

(4) SIMAP similar genes for SPIN2A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPIN2A: view

Variants for SPIN2A Gene

Structural Variations from Database of Genomic Variants (DGV) for SPIN2A Gene

Variant ID Type Subtype PubMed ID
nsv483129 CNV Loss 15286789

Variation tolerance for SPIN2A Gene

Residual Variation Intolerance Score: 68.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.84; 34.48% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for SPIN2A Gene

Disorders for SPIN2A Gene

Relevant External Links for SPIN2A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SPIN2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPIN2A Gene

Publications for SPIN2A Gene

  1. The structure of DXF34, a human X-linked sequence family with homology to a transcribed mouse Y-linked repeat. (PMID: 9271673) Laval S.H. … Boyd Y. (Mamm. Genome 1997) 2 3 4 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins. (PMID: 23891004) Stehling O. … Lill R. (Cell Metab. 2013) 3
  4. A catalogue of putative HIV-1 protease host cell substrates. (PMID: 22944692) Impens F. … Gevaert K. (Biol. Chem. 2012) 3
  5. The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus. (PMID: 23084401) Singh G. … Moore M.J. (Cell 2012) 3

Products for SPIN2A Gene

Sources for SPIN2A Gene