SPIN2A Gene
protein-coding GIFtS: 46
GCID: GC0XM057178
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|
spindlin family, member 2A(Previous names: spindlin family, member 2 )
(Previous symbol: SPIN2)
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Aliases
for SPIN2A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Spindlin Family, Member 2A1 2 | | DJ323P24.11 | | DXF341 2 3 | | Spindlin Homolog 22 | | SPIN21 2 3 | | Spindlin-2A1 | | Spindlin-Like Protein 2A2 3 | | Spindlin-Like Protein 22 | | Spindlin Family, Member 21 | | SPIN-23 | | RP3-323P24.22 | | SPIN-2A3 | | Centromeric Spin2 Copy2 | | Protein DXF343 |
Export aliases for SPIN2A gene to outside databasesPrevious GC identifer: GC0XM054225 |
Summaries
for SPIN2A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SPIN2A:
This gene encodes one of three members of the DXF34 gene family, located in a 100-kb region of chromosome Xp11.21.(provided by RefSeq, Nov 2009)
UniProtKB/Swiss-Prot: SPI2A_HUMAN, Q99865Function: May be involved in the regulation of cell cycle progression (By similarity)
|
Genomic Views
for SPIN2A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011630.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPIN2A gene promoter:
SRF GR USF1 HOXA3 USF-1 GR-beta SRF (504 AA) GR-alpha FOXL1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPIN2A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPIN2A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.1 Ensembl cytogenetic band: Xp11.21 HGNC cytogenetic band: Xp11.1SPIN2A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM057178: view genomic region
(about GC identifiers)
Start:
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57,160,963 bp from pter |
End:
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57,164,058 bp from pter |
Size:
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3,096 bases |
Orientation:
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minus strand |
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Proteins
for SPIN2A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPI2A_HUMAN, Q99865 (See
protein sequence)Recommended Name: Spindlin-2A Size: 258 amino acids; 29188 Da
Sequence caution: Sequence=CAA70988.1; Type=Frameshift; Positions=10;
Secondary accessions: O75650 Q6IPW2 Q9UJJ0Explore the universe of human proteins at neXtProt for SPIN2A: NX_Q99865
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q99865
SPIN2A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_061876.3
ENSEMBL proteins: ENSP00000364043 ENSP00000364041
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
SPIN2A for ontologies About GeneDecksing
SPIN2A Antibody Products:
Assay Products for SPIN2A: |
Protein
Domains /
Families
for SPIN2A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SPIN2A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q99865ProtoNet protein and cluster: Q99865 1 Blocks protein family: IPB003671 Spindlin/spermiogenesis-specific protein
UniProtKB/Swiss-Prot: SPI2A_HUMAN, Q99865Similarity: Belongs to the SPIN/STSY family |
Function
for SPIN2A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SPI2A_HUMAN, Q99865Function: May be involved in the regulation of cell cycle progression (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPIN2A (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPIN2A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for SPIN2A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPIN2A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPIN2A |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
SPIN2A for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SPIN2A:
|
Pathways & Interactions
for SPIN2A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPIN2A
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for SPIN2A (ENSP000003640414) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
SPIN2A for ontologies About GeneDecksing
|
Drugs & Compounds
for SPIN2A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPIN2A
Search CenterWatch for drugs/clinical trials and news about SPIN2A / SPI2A
|
Transcripts
for SPIN2A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPIN2A gene: NM_019003.3 Unigene Cluster for SPIN2A: Spindlin family, member 2A Hs.460725 [show with all ESTs]Unigene Representative Sequence: BC0716942 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000374908(uc022bxx.1) ENST00000374906(uc004dvb.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPIN2A (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPIN2A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SPIN2A (NM_019003) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPIN2A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPIN2A |
Additional cDNA sequence: BC071694.1 4 DOTS entries: DT.100755465 DT.75165080 DT.100803394 DT.310824 13 AceView cDNA sequences: BM973025 BU625654 BC071694 BI523896 BX279774 Y09858 NM_019003 BI524653 CD652258 BQ686850 BQ687902 BE731164 BQ889251
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for SPIN2A About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c |
|---|
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| SP1: | | | | | | | | | - | | - | | | | - | | - | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SPIN2A
|
Expression
for SPIN2A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPIN2A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SPIN2A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPIN2A
SOURCE GeneReport for Unigene cluster: Hs.460725
SABiosciences Custom PCR Arrays for SPIN2A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPIN2A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SPIN2A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPIN2A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPIN2A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPIN2A |
Orthologs
for SPIN2A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SPIN2A gene from 3/9 species (see all 9) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SPIN16 |
-- |
57(a) |
1 → many |
W(144388-156199) |
lizard
(Anolis carolinensis) |
Reptilia |
SPIN16 |
-- |
78(a) |
1 → many |
2(37163227-37172835) |
zebrafish
(Danio rerio) |
Actinopterygii |
CU856539.36 |
-- |
73(a) |
1 → many |
10(2595456-2607514) |
ENSEMBL Gene Tree for SPIN2A (if available)
TreeFam Gene Tree for SPIN2A (if available) |
Paralogs
for SPIN2A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SPIN2A gene
- SPIN2B1 2 SPIN12 SPIN42 SPIN32
4 SIMAP similar genes for SPIN2A using alignment to 1 protein entry: SPI2A_HUMAN:SPIN3 SPIN1 SPIN4 SPIN2B
SPIN2A for paralogs About GeneDecksing
|
Genomic Variants
for SPIN2A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SPIN2A (57160963 - 57164058 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SPIN2A
1 CNV: 0243
Locus Specific Mutation Databases (LSDB): SPIN2A
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPIN2A |
|
Disorders
/ Diseases
for SPIN2A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SPIN2A for disorders About GeneDecksing
OMIM gene information: 300621
OMIM disorders: --
1  disease for SPIN2A: About MalaCardsretinitis
Export disorders for SPIN2A gene to outside databases
|
Publications
for SPIN2A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPIN2A gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with SPIN2A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The structure of DXF34, a human X-linked sequence family with homology to a transcribed mouse Y-linked repeat. (PubMed id 9271673)1, 2, 3 Laval S.H.... Boyd Y. (1997)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A catalogue of putative HIV-1 protease host cell subst rates. (PubMed id 22944692)1 Impens F....Gevaert K. (2012)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. (PubMed id 19377476)1 Tarpey P.S.... Stratton M.R. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Functional cloning of SPIN-2, a nuclear anti-apoptotic protein with roles in cell cycle progression. (PubMed id 12145692)1 Fletcher B.S.... Nolan G.P. (2002)
- Expressed sequence tag analysis of human retina for the NEIBank project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts. (PubMed id 12107411)1 Wistow G.... Peterson K. (2002)
|
External Searches for SPIN2A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SPIN2A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SPIN2A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPIN2A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SPIN2A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SPIN2A gene:
Search GeneIP for patents involving SPIN2A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPIN2A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPIN2A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPIN2A | | | OriGene Protein Over-expression Lysate for SPIN2A | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for SPIN2A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPIN2A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPIN2A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SPIN2A | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SPIN2A | | OriGene Custom Protein Services for SPIN2A | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPIN2A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPIN2A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPIN2A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPIN2A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPIN2A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPIN2A |
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 |  |  |  | |
| | | | Search Tocris compounds for SPIN2A |
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 | | | SPIN2A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPIN2A |
|  |  |  | | | | Search ThermoFisher Antibodies for SPIN2A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPIN2A |
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