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Aliases for SPIN2A Gene

Aliases for SPIN2A Gene

  • Spindlin Family, Member 2A 2 3
  • Spindlin-Like Protein 2A 3 4
  • SPIN2 3 4
  • DXF34 3 4
  • Spindlin Family, Member 2 2
  • Spindlin-Like Protein 2 3
  • Centromeric Spin2 Copy 3
  • Spindlin Homolog 2 3
  • Protein DXF34 4
  • Spindlin-2A 3
  • DJ323P24.1 3
  • SPIN-2A 4
  • SPIN-2 4
  • DSF34 6

External Ids for SPIN2A Gene

Previous HGNC Symbols for SPIN2A Gene

  • SPIN2

Previous GeneCards Identifiers for SPIN2A Gene

  • GC0XM057178
  • GC0XM054225

Summaries for SPIN2A Gene

Entrez Gene Summary for SPIN2A Gene

  • This gene encodes one of three members of the DXF34 gene family, located in a 100-kb region of chromosome Xp11.21. [provided by RefSeq, Nov 2009]

GeneCards Summary for SPIN2A Gene

SPIN2A (Spindlin Family, Member 2A) is a Protein Coding gene. An important paralog of this gene is SPIN2B.

UniProtKB/Swiss-Prot for SPIN2A Gene

  • May be involved in the regulation of cell cycle progression.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPIN2A Gene

Genomics for SPIN2A Gene

Regulatory Elements for SPIN2A Gene

Genomic Location for SPIN2A Gene

57,134,530 bp from pter
57,137,625 bp from pter
3,096 bases
Minus strand

Genomic View for SPIN2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPIN2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPIN2A Gene

Proteins for SPIN2A Gene

  • Protein details for SPIN2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • O75650
    • Q6IPW2
    • Q9UJJ0

    Protein attributes for SPIN2A Gene

    258 amino acids
    Molecular mass:
    29188 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAA70988.1; Type=Frameshift; Positions=10; Evidence={ECO:0000305};

neXtProt entry for SPIN2A Gene

Proteomics data for SPIN2A Gene at MOPED

Post-translational modifications for SPIN2A Gene

  • Ubiquitination at Lys108
  • Modification sites at PhosphoSitePlus

Other Protein References for SPIN2A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPIN2A Gene

Domains for SPIN2A Gene

Protein Domains for SPIN2A Gene

Suggested Antigen Peptide Sequences for SPIN2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q99865
  • Belongs to the SPIN/STSY family.
genes like me logo Genes that share domains with SPIN2A: view

No data available for Gene Families for SPIN2A Gene

Function for SPIN2A Gene

Molecular function for SPIN2A Gene

UniProtKB/Swiss-Prot Function:
May be involved in the regulation of cell cycle progression.

Gene Ontology (GO) - Molecular Function for SPIN2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SPIN2A: view

Phenotypes for SPIN2A Gene

genes like me logo Genes that share phenotypes with SPIN2A: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SPIN2A Gene

Localization for SPIN2A Gene

Subcellular locations from

Jensen Localization Image for SPIN2A Gene COMPARTMENTS Subcellular localization image for SPIN2A gene
Compartment Confidence
cytosol 2
nucleus 2
peroxisome 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SPIN2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SPIN2A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SPIN2A Gene

Pathways for SPIN2A Gene

SuperPathways for SPIN2A Gene

No Data Available

Interacting Proteins for SPIN2A Gene

Gene Ontology (GO) - Biological Process for SPIN2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007276 gamete generation IEA --
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with SPIN2A: view

No data available for Pathways by source for SPIN2A Gene

Transcripts for SPIN2A Gene

mRNA/cDNA for SPIN2A Gene

(13) Selected AceView cDNA sequences:
(6) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPIN2A Gene

Spindlin family, member 2A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPIN2A

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPIN2A Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3a · 3b · 3c
SP1: - - - -
SP2: -
SP3: - -
SP4: - -

Relevant External Links for SPIN2A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPIN2A Gene

mRNA expression in normal human tissues for SPIN2A Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPIN2A Gene

SOURCE GeneReport for Unigene cluster for SPIN2A Gene Hs.460725

genes like me logo Genes that share expressions with SPIN2A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for SPIN2A Gene

Orthologs for SPIN2A Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPIN2A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SPIN2B 35
  • 87.6 (n)
  • 84.88 (a)
-- 36
  • 95 (a)
-- 36
  • 85 (a)
(Mus musculus)
Mammalia Gm3757 35
  • 73.15 (n)
  • 66.06 (a)
Spin2 16
Gm2854 36
  • 64 (a)
Gm5926 36
  • 62 (a)
Spin2-ps5 36
  • 62 (a)
Spin2-ps6 36
  • 61 (a)
Spin2d 36
  • 64 (a)
Spin2e 36
  • 63 (a)
Spin2f 36
  • 61 (a)
(Pan troglodytes)
Mammalia SPIN2A 35
  • 99.35 (n)
  • 98.84 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC367746 35
  • 81.6 (n)
  • 78.4 (a)
(Canis familiaris)
Mammalia -- 36
  • 97 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 77 (a)
(Gallus gallus)
Aves SPINW 36
  • 70 (a)
  • 77 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 77 (a)
Species with no ortholog for SPIN2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPIN2A Gene

Gene Tree for SPIN2A (if available)
Gene Tree for SPIN2A (if available)

Paralogs for SPIN2A Gene

Paralogs for SPIN2A Gene

Selected SIMAP similar genes for SPIN2A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPIN2A: view

Variants for SPIN2A Gene

Sequence variations from dbSNP and Humsavar for SPIN2A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs909654 -- 57,135,423(-) GCTTA(A/G)GAAGA downstream-variant-500B
rs2003812 -- 57,136,462(-) AGCCC(C/T)GCAGG reference, missense
rs2020223 -- 57,136,466(+) CGGGG(C/T)TGGGA synonymous-codon, reference
rs2020226 -- 57,135,842(-) GTCTA(C/T)GATTT reference, synonymous-codon
rs4266782 -- 57,136,480(+) AGGTC(G/T)GCCTC synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for SPIN2A Gene

Variant ID Type Subtype PubMed ID
nsv483129 CNV Loss 15286789

Relevant External Links for SPIN2A Gene

HapMap Linkage Disequilibrium report
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPIN2A Gene

Disorders for SPIN2A Gene

No disorders were found for SPIN2A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for SPIN2A Gene

Publications for SPIN2A Gene

  1. The structure of DXF34, a human X-linked sequence family with homology to a transcribed mouse Y-linked repeat. (PMID: 9271673) Laval S.H. … Boyd Y. (Mamm. Genome 1997) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. (PMID: 19377476) Tarpey P.S. … Stratton M.R. (Nat. Genet. 2009) 3

Products for SPIN2A Gene

Sources for SPIN2A Gene

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