Aliases for SPIN1 Gene
External Ids for SPIN1 Gene
Previous HGNC Symbols for SPIN1 Gene
Previous GeneCards Identifiers for SPIN1 Gene
GeneCards Summary for SPIN1 Gene
SPIN1 (Spindlin 1) is a Protein Coding gene. GO annotations related to this gene include methylated histone binding. An important paralog of this gene is SPIN3.
UniProtKB/Swiss-Prot for SPIN1 Gene
Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at Lys-4 and asymmetrically dimethylated at Arg-8 (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.