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SPIN1 Gene

protein-coding   GIFtS: 54
GCID: GC09P091003

Spindlin 1

(Previous name: spindlin)
(Previous symbol: SPIN)
  See SPIN1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Spindlin 11 2
SPIN1 2 3 5
Ovarian Cancer-Related Protein2 3
spindlin1
spindlin-12
OCR3

External Ids:    HGNC: 112431   Entrez Gene: 109272   Ensembl: ENSG000001067237   OMIM: 6099365   UniProtKB: Q9Y6573   

Export aliases for SPIN1 gene to outside databases

Previous GC identifers: GC16P028894 GC09P090194 GC09P060869


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SPIN1 Gene:
SPIN1 (spindlin 1) is a protein-coding gene. Diseases associated with SPIN1 include ovarian cancer. GO annotations related to this gene include methylated histone residue binding. An important paralog of this gene is SPIN2B.

UniProtKB/Swiss-Prot: SPIN1_HUMAN, Q9Y657
Function: May play a role in cell-cycle regulation during the transition from gamete to embryo (By similarity)

Gene Wiki entry for SPIN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPIN1 gene promoter:
         Pbx1a   FOXF2   FOXO3   FOXO3b   FOXL1   MEF-2A   HSF2   FOXO3a   aMEF-2   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPIN1 promoter sequence
   Search Chromatin IP Primers for SPIN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPIN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.1   Ensembl cytogenetic band:  9q22.1   HGNC cytogenetic band: 9q22.1

SPIN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPIN1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P091003:  view genomic region     (about GC identifiers)

Start:
91,003,297 bp from pter      End:
91,093,623 bp from pter
Size:
90,327 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SPIN1_HUMAN, Q9Y657 (See protein sequence)
Recommended Name: Spindlin-1  
Size: 262 amino acids; 29601 Da
Subunit: Homodimer; may form higher-order oligomers
Sequence caution: Sequence=AAD43035.1; Type=Frameshift; Positions=21; Sequence=AAG38112.1; Type=Erroneous
initiation; Sequence=AAG48367.1; Type=Erroneous initiation; Sequence=CAB66653.1; Type=Erroneous termination;
Positions=171; Note=Translated as Glu; Sequence=CAG38515.1; Type=Erroneous termination; Positions=171;
Note=Translated as Glu;
2 PDB 3D structures from and Proteopedia for SPIN1:
2NS2 (3D)        4H75 (3D)    
Secondary accessions: A8K0X6 B3KRQ4 Q7KZJ8 Q9GZT2 Q9H0N7

Explore the universe of human proteins at neXtProt for SPIN1: NX_Q9Y657

Explore proteomics data for SPIN1 at MOPED

Post-translational modifications: 

  • Phosphorylated during oocyte meiotic maturation (By similarity)1
  • Ubiquitination2 at Lys63
  • Modification sites at PhosphoSitePlus

  • See SPIN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006708.2  
    ENSEMBL proteins: 
     ENSP00000365019   ENSP00000441864  

    SPIN1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SPIN1

     
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    antibodies-online proteins for SPIN1 (5 products) 

     
    antibodies-online peptides for SPIN1

    SPIN1 Antibody Products:

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    antibodies-online antibodies for SPIN1 (31 products) 

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    Cloud-Clone Corp. CLIAs for SPIN1
    Search eBioscience for ELISAs for SPIN1 
    antibodies-online kits for SPIN1 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003671 Spin_Ssty

    Graphical View of Domain Structure for InterPro Entry Q9Y657

    ProtoNet protein and cluster: Q9Y657

    1 Blocks protein domain: IPB003671 Spindlin/spermiogenesis-specific protein

    UniProtKB/Swiss-Prot: SPIN1_HUMAN, Q9Y657
    Similarity: Belongs to the SPIN/STSY family


    Find genes that share domains with SPIN1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPIN1_HUMAN, Q9Y657
    Function: May play a role in cell-cycle regulation during the transition from gamete to embryo (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0035064methylated histone residue binding IDA--
         
    Find genes that share ontologies with SPIN1           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Spin1):
     mortality/aging  reproductive system 

    Find genes that share phenotypes with SPIN1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SPIN1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SPIN1:
    hsa-mir-124-3p (MIRT022322), hsa-mir-155-5p (MIRT020543), hsa-mir-21-5p (MIRT030784), hsa-mir-598-3p (MIRT040485)

    Block miRNA regulation of human, mouse, rat SPIN1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SPIN1 (see all 88):
    hsa-miR-124* hsa-miR-3678-3p hsa-miR-100* hsa-miR-607 hsa-miR-629 hsa-miR-4325 hsa-miR-489 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidSPIN1 3' UTR sequence
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPIN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPIN1

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPIN1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPIN1_HUMAN, Q9Y657: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton2
    mitochondrion2
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005819spindle IEA--

    Find genes that share ontologies with SPIN1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPIN1
    Interactions:

        Search GeneGlobe Interaction Network for SPIN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for SPIN1 (Q9Y6572, 3 ENSP000003650194) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTNP212462, 3MINT-64750 I2D: score=4 
    AGO3Q9H9G73, ENSP000003622874I2D: score=2 STRING: ENSP00000362287
    ARRB1P494073I2D: score=1 
    ARRB2P321213I2D: score=1 
    LSM8ENSP000002492994STRING: ENSP00000249299
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007049cell cycle IEA--
    GO:0007275multicellular organismal development IEA--
    GO:0007276gamete generation IEA--

    Find genes that share ontologies with SPIN1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPIN1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SPIN1 gene: 
    NM_006717.2  

    Unigene Cluster for SPIN1:

    Spindlin 1
    Hs.146804  [show with all ESTs]
    Unigene Representative Sequence: NM_006717
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375859(uc010mqj.3 uc004apy.3 uc004apz.3 uc010mqk.3)
    ENST00000485804 ENST00000469017 ENST00000462844 ENST00000485565 ENST00000483785
    ENST00000541629
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SPIN1 (see all 88):
    hsa-miR-124* hsa-miR-3678-3p hsa-miR-100* hsa-miR-607 hsa-miR-629 hsa-miR-4325 hsa-miR-489 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidSPIN1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SPIN1
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    GenScript: all cDNA clones in your preferred vector: SPIN1 (NM_006717)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPIN1
    Primer
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    OriGene qPCR primer pairs and template standards for SPIN1
    OriGene qSTAR qPCR primer pairs in human, mouse for SPIN1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SPIN1
      QuantiTect SYBR Green Assays in human, mouse, rat SPIN1
      QuantiFast Probe-based Assays in human, mouse, rat SPIN1

    Additional mRNA sequence: 

    AF087864.1 AF106682.1 AF317228.2 AJ420427.1 AK024590.1 AK027044.1 AK092017.1 AK289691.1 
    AK290009.1 AK315854.1 AL136719.1 BC114515.1 BC114565.1 BT007314.1 CR533484.1 

    24 DOTS entries:

    DT.100797415  DT.100797398  DT.118972  DT.100797394  DT.95097040  DT.100797416  DT.95354983  DT.100797419 
    DT.97855040  DT.121161252  DT.121161317  DT.91762559  DT.99982992  DT.102833565  DT.121161237  DT.121161272 
    DT.121161311  DT.121161327  DT.75141648  DT.91762549  DT.100797417  DT.100819189  DT.121161291  DT.92015963 

    Selected AceView cDNA sequences (see all 433):

    CD677802 BX104249 AA722432 AI989916 BQ632665 BT007314 F02450 AI698374 
    CD676984 BQ425311 H88245 BM710692 AL541249 BU741763 Z41615 CA314010 
    BM454499 AI457693 AI799316 AA461287 BU623192 BQ774489 AA332788 AL045235 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SPIN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGCATTTGA
    SPIN1 Expression
    About this image


    SPIN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Zygote (Early Embryonic Tissues)    fully expand to see all 2 entries
             2-Cell Embryo Zygote
     
     Inner Cell Mass (Early Embryo)    fully expand to see all 2 entries
             2-Cell Embryo Zygote
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             2-Cell Embryo Zygote
     
     Ovary (Reproductive System)
             Secondary Oocyte Antral Follicle
     
     Gonad
             Secondary Oocyte Antral Follicle
    SPIN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPIN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.146804
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SPIN1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spin11 , 5 spindlin 11, 5 93(n)1
    99.24(a)1
      13 (26.04 cM)5
    207291  NM_001283028.11  NP_001269957.11 
     511008985 
    chicken
    (Gallus gallus)
    Aves SPINZ1 spindlin 1 88.42(n)
    96.56(a)
      395344  NM_204633.1  NP_989964.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    96(a)
    1 → many
    2(37159109-37173005)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.200832 Xenopus laevis transcribed sequence with strong similarity more 82.54(n)    BJ041975.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7928221 spindlin-Z-like 75.57(n)
    89.69(a)
      792822  XM_001331747.3  XP_001331783.2 


    ENSEMBL Gene Tree for SPIN1 (if available)
    TreeFam Gene Tree for SPIN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SPIN1 gene
    SPIN2B2  SPIN2A2  SPIN42  SPIN32  
    4 SIMAP similar genes for SPIN1 using alignment to 1 protein entry:     SPIN1_HUMAN:
    SPIN3    SPIN2A    SPIN4    SPIN2B

    Find genes that share paralogs with SPIN1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SPIN1 (see all 2038)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1400732651,2
    C--91001439(+) AAGACA/GTTTTC 1 -- us2k10--------
    rs78649641,2
    C,F,A--91001440(+) AGACGT/GTTTCC 1 -- us2k1 tfbs34Minor allele frequency- G:0.36WA CSA 124
    rs1151500661,2
    C,F--91001468(+) GTGTGT/CGCTAC 1 -- us2k11Minor allele frequency- C:0.08WA 118
    rs1436272431,2
    --91001470(+) GTGTGC/TTACTG 1 -- us2k10--------
    rs1864103611,2
    --91001546(+) TGAAAA/GGATTA 1 -- us2k10--------
    rs734980701,2
    C,F--91001567(+) AAAGCC/TAACAC 1 -- us2k12Minor allele frequency- T:0.06WA 120
    rs1900222921,2
    --91001592(+) AACCCA/GGGGAT 1 -- us2k10--------
    rs78525301,2
    C,F--91001604(+) TCGCCA/GATGAG 1 -- us2k12Minor allele frequency- G:0.12WA 120
    rs1467813181,2
    C--91001679(+) GATGAC/TCCCAC 1 -- us2k10--------
    rs78528021,2
    C--91001797(+) ggccaA/Gcatgg 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SPIN1 (91003297 - 91093623 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SPIN1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2658159CNV Deletion23128226
    esv2661430CNV Deletion23128226
    esv2667394CNV Deletion23128226
    nsv831649CNV Loss17160897
    esv23316CNV Loss19812545
    nsv466432CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SPIN1
    DNA2.0 Custom Variant and Variant Library Synthesis for SPIN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609936    OMIM disorders: --

    1 disease for SPIN1:    
    About MalaCards
    ovarian cancer


    Find genes that share disorders with SPIN1           About GenesLikeMe

    Genetic Association Database (GAD): SPIN1
    Human Genome Epidemiology (HuGE) Navigator: SPIN1 (1 document)

    Export disorders for SPIN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SPIN1 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with SPIN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Spindlin1, a novel nuclear protein with a role in the transformation of NIH3T3 cells. (PubMed id 16098913)1, 2, 3 Gao Y.... Pei X. (Biochem. Biophys. Res. Commun. 2005)
    2. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    3. Structure of human spindlin1. Tandem tudor-like domains for cell cycle regulation. (PubMed id 17082182)1, 2 Zhao Q.... Rao Z. (J. Biol. Chem. 2007)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    8. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (J. Proteome Res. 2013)
    9. Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. (PubMed id 23184937)1 Xie Y....Cong F. (J. Biol. Chem. 2013)
    10. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10927 HGNC: 11243 AceView: SPIN Ensembl:ENSG00000106723 euGenes: HUgn10927
    ECgene: SPIN1 H-InvDB: SPIN1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SPIN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SPIN1 gene:
    Search GeneIP for patents involving SPIN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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