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Aliases for SPIN1 Gene

Aliases for SPIN1 Gene

  • Spindlin 1 2 3 5
  • Ovarian Cancer-Related Protein 3 4
  • Spindlin1 3 4
  • SPIN 3 4
  • Spindlin 2
  • TDRD24 3
  • OCR 4

External Ids for SPIN1 Gene

Previous HGNC Symbols for SPIN1 Gene

  • SPIN

Previous GeneCards Identifiers for SPIN1 Gene

  • GC16P028894
  • GC09P090194
  • GC09P091003
  • GC09P060869

Summaries for SPIN1 Gene

GeneCards Summary for SPIN1 Gene

SPIN1 (Spindlin 1) is a Protein Coding gene. Diseases associated with SPIN1 include ovarian cancer. GO annotations related to this gene include methylated histone binding. An important paralog of this gene is SPIN2B.

UniProtKB/Swiss-Prot for SPIN1 Gene

  • Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at Lys-4 and asymmetrically dimethylated at Arg-8 (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway dowstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.

Gene Wiki entry for SPIN1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPIN1 Gene

Genomics for SPIN1 Gene

Regulatory Elements for SPIN1 Gene

Promoters for SPIN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SPIN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPIN1 Gene

Chromosome:
9
Start:
88,388,382 bp from pter
End:
88,478,708 bp from pter
Size:
90,327 bases
Orientation:
Plus strand

Genomic View for SPIN1 Gene

Genes around SPIN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPIN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPIN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPIN1 Gene

Proteins for SPIN1 Gene

  • Protein details for SPIN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y657-SPIN1_HUMAN
    Recommended name:
    Spindlin-1
    Protein Accession:
    Q9Y657
    Secondary Accessions:
    • A8K0X6
    • B3KRQ4
    • Q7KZJ8
    • Q9GZT2
    • Q9H0N7

    Protein attributes for SPIN1 Gene

    Size:
    262 amino acids
    Molecular mass:
    29601 Da
    Quaternary structure:
    • Homodimer; may form higher-order oligomers (PubMed:17082182). Interacts with TCF7L2/TCF4; the interaction is direct. Interacts with HABP4 and SERBP1.
    SequenceCaution:
    • Sequence=AAD43035.1; Type=Frameshift; Positions=21; Evidence={ECO:0000305}; Sequence=AAG38112.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAG48367.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB66653.1; Type=Erroneous termination; Positions=171; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=CAG38515.1; Type=Erroneous termination; Positions=171; Note=Translated as Glu.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SPIN1 Gene

neXtProt entry for SPIN1 Gene

Proteomics data for SPIN1 Gene at MOPED

Post-translational modifications for SPIN1 Gene

Other Protein References for SPIN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SPIN1 Gene

Domains & Families for SPIN1 Gene

Gene Families for SPIN1 Gene

Protein Domains for SPIN1 Gene

Suggested Antigen Peptide Sequences for SPIN1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y657

UniProtKB/Swiss-Prot:

SPIN1_HUMAN :
  • The 3 tudor-like domains (also named Spin/Ssty repeats) specifically recognize and bind methylated histones (PubMed:23077255, PubMed:24589551). H3K4me3 and H3R8me2a are recognized by tudor-like domains 2 and 1, respectively (PubMed:24589551).
  • Belongs to the SPIN/STSY family.
Domain:
  • The 3 tudor-like domains (also named Spin/Ssty repeats) specifically recognize and bind methylated histones (PubMed:23077255, PubMed:24589551). H3K4me3 and H3R8me2a are recognized by tudor-like domains 2 and 1, respectively (PubMed:24589551).
Family:
  • Belongs to the SPIN/STSY family.
genes like me logo Genes that share domains with SPIN1: view

Function for SPIN1 Gene

Molecular function for SPIN1 Gene

UniProtKB/Swiss-Prot Function:
Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at Lys-4 and asymmetrically dimethylated at Arg-8 (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway dowstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.
genes like me logo Genes that share phenotypes with SPIN1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SPIN1

miRNA for SPIN1 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPIN1 Gene

Localization for SPIN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPIN1 Gene

Nucleus. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPIN1 Gene COMPARTMENTS Subcellular localization image for SPIN1 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
mitochondrion 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for SPIN1 Gene

Pathways & Interactions for SPIN1 Gene

SuperPathways for SPIN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0009303 rRNA transcription IDA 21960006
GO:0030177 positive regulation of Wnt signaling pathway IDA 24589551
genes like me logo Genes that share ontologies with SPIN1: view

No data available for Pathways by source and SIGNOR curated interactions for SPIN1 Gene

Drugs & Compounds for SPIN1 Gene

No Compound Related Data Available

Transcripts for SPIN1 Gene

Unigene Clusters for SPIN1 Gene

Spindlin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPIN1 Gene

No ASD Table

Relevant External Links for SPIN1 Gene

GeneLoc Exon Structure for
SPIN1
ECgene alternative splicing isoforms for
SPIN1

Expression for SPIN1 Gene

mRNA expression in normal human tissues for SPIN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SPIN1 Gene

This gene is overexpressed in Uterus (14.9), Fetal testis (11.4), Fetal Brain (9.7), and Fetal ovary (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPIN1 Gene



SOURCE GeneReport for Unigene cluster for SPIN1 Gene Hs.146804

mRNA Expression by UniProt/SwissProt for SPIN1 Gene

Q9Y657-SPIN1_HUMAN
Tissue specificity: Highly expressed in ovarian cancer tissues.
genes like me logo Genes that share expression patterns with SPIN1: view

Protein tissue co-expression partners for SPIN1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SPIN1 Gene

Orthologs for SPIN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPIN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPIN1 35
  • 99.87 (n)
  • 100 (a)
SPIN1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPIN1 36
  • 99 (a)
OneToOne
SPIN1 35
  • 95.04 (n)
  • 99.24 (a)
dog
(Canis familiaris)
Mammalia SPIN1 35
  • 93 (n)
  • 99.24 (a)
SPIN1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spin1 36
  • 99 (a)
OneToOne
Spin1 16
Spin1 35
  • 93 (n)
  • 99.24 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 97 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC100363675 35
  • 92.24 (n)
  • 98.85 (a)
chicken
(Gallus gallus)
Aves SPINW 36
  • 83 (a)
ManyToMany
SPINZ 36
  • 97 (a)
ManyToMany
SPINZ 35
  • 88.42 (n)
  • 96.56 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 96 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.20083 35
tropical clawed frog
(Silurana tropicalis)
Amphibia spin1 35
  • 83.84 (n)
  • 94.27 (a)
Str.20395 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4056 35
zebrafish
(Danio rerio)
Actinopterygii LOC792822 35
  • 75.57 (n)
  • 89.69 (a)
Species with no ortholog for SPIN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPIN1 Gene

ENSEMBL:
Gene Tree for SPIN1 (if available)
TreeFam:
Gene Tree for SPIN1 (if available)

Paralogs for SPIN1 Gene

Paralogs for SPIN1 Gene

(4) SIMAP similar genes for SPIN1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPIN1: view

Variants for SPIN1 Gene

Sequence variations from dbSNP and Humsavar for SPIN1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs34794905 - 88,475,149(+) AATAT(C/G)CCAAA reference, missense
rs1137494 -- 88,411,947(+) cgggc(A/G)gatcg intron-variant
rs1137495 -- 88,411,952(+) ggatc(A/G)cgagg intron-variant
rs1169881 -- 88,461,391(-) TTCTC(C/T)CCTGG intron-variant
rs1169882 -- 88,435,318(-) gattc(A/G)cttga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPIN1 Gene

Variant ID Type Subtype PubMed ID
nsv831649 CNV Loss 17160897
esv23316 CNV Loss 19812545
esv2667394 CNV Deletion 23128226
esv2661430 CNV Deletion 23128226
nsv466432 CNV Gain 19166990
esv2658159 CNV Deletion 23128226

Variation tolerance for SPIN1 Gene

Residual Variation Intolerance Score: 36.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPIN1 Gene

HapMap Linkage Disequilibrium report
SPIN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPIN1 Gene

Disorders for SPIN1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SPIN1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ovarian cancer
  • malignant ovarian tumor
- elite association - COSMIC cancer census association via MalaCards
Search SPIN1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SPIN1

Genetic Association Database (GAD)
SPIN1
Human Genome Epidemiology (HuGE) Navigator
SPIN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPIN1
genes like me logo Genes that share disorders with SPIN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPIN1 Gene

Publications for SPIN1 Gene

  1. Spindlin1, a novel nuclear protein with a role in the transformation of NIH3T3 cells. (PMID: 16098913) Gao Y. … Pei X. (Biochem. Biophys. Res. Commun. 2005) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. (PMID: 26460568) Johnson-Kerner B.L. … Wichterle H. (PLoS ONE 2015) 3
  4. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M. … Rocchi P. (Mol. Cell Proteomics 2014) 3
  5. Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1. (PMID: 24589551) Su X. … Li H. (Genes Dev. 2014) 3

Products for SPIN1 Gene

Sources for SPIN1 Gene

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