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Aliases for SPIN1 Gene

Aliases for SPIN1 Gene

  • Spindlin 1 2 3
  • Ovarian Cancer-Related Protein 3 4
  • Spindlin1 3 4
  • SPIN 3 4
  • Spindlin-1 3
  • Spindlin 2
  • SPIN, 6
  • OCR 4

External Ids for SPIN1 Gene

Previous Symbols for SPIN1 Gene

  • SPIN

Summaries for SPIN1 Gene

GeneCards Summary for SPIN1 Gene

SPIN1 (Spindlin 1) is a Protein Coding gene. GO annotations related to this gene include methylated histone binding. An important paralog of this gene is SPIN2B.

UniProtKB/Swiss-Prot for SPIN1 Gene

  • Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at Lys-4 and asymmetrically dimethylated at Arg-8 (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway dowstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.

Gene Wiki entry for SPIN1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPIN1 Gene

Genomics for SPIN1 Gene

Genomic Location for SPIN1 Gene

Start:
88,388,382 bp from pter
End:
88,478,708 bp from pter
Size:
90,327 bases
Orientation:
Plus strand

Genomic View for SPIN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPIN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPIN1 Gene

Regulatory Elements for SPIN1 Gene

Proteins for SPIN1 Gene

  • Protein details for SPIN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y657-SPIN1_HUMAN
    Recommended name:
    Spindlin-1
    Protein Accession:
    Q9Y657
    Secondary Accessions:
    • A8K0X6
    • B3KRQ4
    • Q7KZJ8
    • Q9GZT2
    • Q9H0N7

    Protein attributes for SPIN1 Gene

    Size:
    262 amino acids
    Molecular mass:
    29601 Da
    Quaternary structure:
    • Homodimer; may form higher-order oligomers (PubMed:17082182). Interacts with TCF7L2/TCF4; the interaction is direct. Interacts with HABP4 and SERBP1.
    SequenceCaution:
    • Sequence=AAD43035.1; Type=Frameshift; Positions=21; Evidence={ECO:0000305}; Sequence=AAG38112.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAG48367.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB66653.1; Type=Erroneous termination; Positions=171; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=CAG38515.1; Type=Erroneous termination; Positions=171; Note=Translated as Glu.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SPIN1 Gene

neXtProt entry for SPIN1 Gene

Proteomics data for SPIN1 Gene at MOPED

Post-translational modifications for SPIN1 Gene

Other Protein References for SPIN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPIN1 Gene

Domains for SPIN1 Gene

Protein Domains for SPIN1 Gene

UniProtKB/Swiss-Prot:

SPIN1_HUMAN
Domain:
  • The 3 tudor-like domains (also named Spin/Ssty repeats) specifically recognize and bind methylated histones (PubMed:23077255, PubMed:24589551). H3K4me3 and H3R8me2a are recognized by tudor-like domains 2 and 1, respectively (PubMed:24589551).:
    • Q9Y657
Family:
  • Belongs to the SPIN/STSY family.:
    • Q9Y657
genes like me logo Genes that share domains with SPIN1: view

No data available for Gene Families for SPIN1 Gene

Function for SPIN1 Gene

Molecular function for SPIN1 Gene

UniProtKB/Swiss-Prot Function: Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at Lys-4 and asymmetrically dimethylated at Arg-8 (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway dowstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.

Gene Ontology (GO) - Molecular Function for SPIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24589551
GO:0035064 methylated histone binding IDA 21029866
genes like me logo Genes that share ontologies with SPIN1: view

Phenotypes for SPIN1 Gene

genes like me logo Genes that share phenotypes with SPIN1: view

miRNA for SPIN1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SPIN1 Gene

Localization for SPIN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPIN1 Gene

Nucleus. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPIN1 Gene COMPARTMENTS Subcellular localization image for SPIN1 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for SPIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA 21960006
GO:0005819 spindle IEA --
genes like me logo Genes that share ontologies with SPIN1: view

Pathways for SPIN1 Gene

SuperPathways for SPIN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0007276 gamete generation IEA --
GO:0009303 rRNA transcription IDA 21960006
GO:0016055 Wnt signaling pathway IEA --
GO:0016568 chromatin modification IEA --
genes like me logo Genes that share ontologies with SPIN1: view

No data available for Pathways by source for SPIN1 Gene

Transcripts for SPIN1 Gene

Unigene Clusters for SPIN1 Gene

Spindlin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPIN1 Gene

No ASD Table

Relevant External Links for SPIN1 Gene

GeneLoc Exon Structure for
SPIN1
ECgene alternative splicing isoforms for
SPIN1

Expression for SPIN1 Gene

mRNA expression in normal human tissues for SPIN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPIN1 Gene

SOURCE GeneReport for Unigene cluster for SPIN1 Gene Hs.146804

mRNA Expression by UniProt/SwissProt for SPIN1 Gene

Q9Y657-SPIN1_HUMAN
Tissue specificity: Highly expressed in ovarian cancer tissues.
genes like me logo Genes that share expressions with SPIN1: view

Orthologs for SPIN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPIN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPIN1 36
  • 99.87 (n)
  • 100 (a)
SPIN1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPIN1 36
  • 95.04 (n)
  • 99.24 (a)
SPIN1 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPIN1 36
  • 93 (n)
  • 99.24 (a)
SPIN1 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spin1 36
  • 93 (n)
  • 99.24 (a)
Spin1 16
Spin1 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 97 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC100363675 36
  • 92.24 (n)
  • 98.85 (a)
chicken
(Gallus gallus)
Aves SPINW 37
  • 83 (a)
ManyToMany
SPINZ 36
  • 88.42 (n)
  • 96.56 (a)
SPINZ 37
  • 97 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 96 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.20083 36
tropical clawed frog
(Silurana tropicalis)
Amphibia spin1 36
  • 83.84 (n)
  • 94.27 (a)
Str.20395 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4056 36
zebrafish
(Danio rerio)
Actinopterygii LOC792822 36
  • 75.57 (n)
  • 89.69 (a)
Species with no ortholog for SPIN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPIN1 Gene

ENSEMBL:
Gene Tree for SPIN1 (if available)
TreeFam:
Gene Tree for SPIN1 (if available)

Paralogs for SPIN1 Gene

Paralogs for SPIN1 Gene

Selected SIMAP similar genes for SPIN1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPIN1: view

Variants for SPIN1 Gene

Sequence variations from dbSNP and Humsavar for SPIN1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs9665 -- 88,475,836(-) CATGA(C/T)TGACT utr-variant-3-prime
rs1043358 -- 88,477,995(+) GTTTT(C/T)TTTAT utr-variant-3-prime
rs1056657 -- 88,413,942(+) AAATG(C/T)GGAGG intron-variant
rs1134884 -- 88,413,484(+) gttca(A/G)gtgat intron-variant
rs1134886 -- 88,413,517(+) tagct(C/G)gcact intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPIN1 Gene

Variant ID Type Subtype PubMed ID
nsv831649 CNV Loss 17160897
esv23316 CNV Loss 19812545
esv2667394 CNV Deletion 23128226
esv2661430 CNV Deletion 23128226
nsv466432 CNV Gain 19166990
esv2658159 CNV Deletion 23128226

Relevant External Links for SPIN1 Gene

HapMap Linkage Disequilibrium report
SPIN1

Disorders for SPIN1 Gene

Relevant External Links for SPIN1

Genetic Association Database (GAD)
SPIN1
Human Genome Epidemiology (HuGE) Navigator
SPIN1
genes like me logo Genes that share disorders with SPIN1: view

No data available for UniProtKB/Swiss-Prot for SPIN1 Gene

Publications for SPIN1 Gene

  1. Spindlin1, a novel nuclear protein with a role in the transformation of NIH3T3 cells. (PMID: 16098913) Gao Y. … Pei X. (Biochem. Biophys. Res. Commun. 2005) 2 3 4
  2. Nucleolar protein Spindlin1 recognizes H3K4 methylation and stimulates the expression of rRNA genes. (PMID: 21960006) Wang W. … Zhu B. (EMBO Rep. 2011) 3 4
  3. SPINDLIN1 promotes cancer cell proliferation through activation of WNT/TCF-4 signaling. (PMID: 22258766) Wang J.X. … Pei X.T. (Mol. Cancer Res. 2012) 3 4
  4. Distinct mode of methylated lysine-4 of histone H3 recognition by tandem tudor-like domains of Spindlin1. (PMID: 23077255) Yang N. … Xu R.M. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3 4
  5. Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1. (PMID: 24589551) Su X. … Li H. (Genes Dev. 2014) 3 4

Products for SPIN1 Gene

Sources for SPIN1 Gene

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