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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SPIN1 Gene

protein-coding GIFtS: 51
GCID: GC09P091003

spindlin 1

(Previous name: spindlin )
(Previous symbol: SPIN)

Explore 1 disease affiliated with
SPIN1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Spindlin 1¹ ²
SPIN¹ ² ³ ⁵
Ovarian Cancer-Related Protein² ³
Spindlin¹
Spindlin-1¹
OCR³

External Ids:	HGNC: 11243¹	Entrez Gene: 10927²	Ensembl: ENSG00000106723⁷	OMIM: 609936⁵	UniProtKB: Q9Y657³

Export aliases for SPIN1 gene to outside databases

Previous GC identifers: GC16P028894 GC09P090194 GC09P060869

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SPIN1_HUMAN, Q9Y657

Function: May play a role in cell-cycle regulation during the transition from gamete to embryo (By similarity)

Gene Wiki entry for SPIN1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008470.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SPIN1 gene promoter:
Pbx1a FOXF2 FOXO3 FOXO3b FOXL1 MEF-2A HSF2 FOXO3a aMEF-2 En-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SPIN1 promoter sequence

Search SABiosciences Chromatin IP Primers for SPIN1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPIN1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.1 Ensembl cytogenetic band: 9q22.1 HGNC cytogenetic band: 9q22.1

SPIN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPIN1 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P091003: view genomic region (about GC identifiers)

Start:	91,003,297 bp from pter	End:	91,093,623 bp from pter
Size:	90,327 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SPIN1_HUMAN, Q9Y657 (See protein sequence)

Recommended Name: Spindlin-1

Size: 262 amino acids; 29601 Da

Subunit: Homodimer; may form higher-order oligomers

Subcellular location: Nucleus

Sequence caution: Sequence=AAD43035.1; Type=Frameshift; Positions=21; Sequence=AAG38112.1; Type=Erroneous initiation;

Sequence=AAG48367.1; Type=Erroneous initiation; Sequence=CAB66653.1; Type=Erroneous termination; Positions=171;

Note=Translated as Glu; Sequence=CAG38515.1; Type=Erroneous termination; Positions=171; Note=Translated as Glu;

2 PDB 3D structures from and Proteopedia for SPIN1:

2NS2 (3D)

4H75 (3D)

Secondary accessions: A8K0X6 B3KRQ4 Q7KZJ8 Q9GZT2 Q9H0N7

Explore the universe of human proteins at neXtProt for SPIN1: NX_Q9Y657

Post-translational modifications:

Phosphorylated during oocyte meiotic maturation (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y657

SPIN1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006708.2

ENSEMBL proteins:

ENSP00000365019 ENSP00000441864

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: SPIN1 OriGene Protein Over-expression Lysate: SPIN1 OriGene Custom Protein Services for SPIN1
	GenScript Custom Purified and Recombinant Proteins Services for SPIN1
	Novus Biologicals SPIN1 Proteins Novus Biologicals SPIN1 Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for SPIN1
	Uscn Proteins for SPIN1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005819	spindle	IEA	--

SPIN1 for ontologies About GeneDecksing

SPIN1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for SPIN1
	GenScript Custom Superior Antibodies Services for SPIN1
	Novus Biologicals SPIN1 Antibody
	Search for Antibodies for SPIN1 at Abcam
	Uscn Antibodies for SPIN1
	Search ThermoFisher Antibodies for SPIN1

Assay Products for SPIN1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SPIN1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SPIN1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SPIN1 for domains About GeneDecksing

1 InterPro domain/family:

IPR003671 Spin_Ssty

Graphical View of Domain Structure for InterPro Entry Q9Y657

ProtoNet protein and cluster: Q9Y657

1 Blocks protein family: IPB003671 Spindlin/spermiogenesis-specific protein

UniProtKB/Swiss-Prot: SPIN1_HUMAN, Q9Y657

Similarity: Belongs to the SPIN/STSY family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SPIN1_HUMAN, Q9Y657

Function: May play a role in cell-cycle regulation during the transition from gamete to embryo (By similarity)

miRNA Products:		OriGene 3'-UTR Clone: SPIN1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPIN1
		8/88 QIAGEN miScript miRNA Assays for microRNAs that regulate SPIN1 (see all 88):
		hsa-miR-124* hsa-miR-3678-3p hsa-miR-100* hsa-miR-607 hsa-miR-629 hsa-miR-4325 hsa-miR-489 hsa-miR-3613-3p

		SwitchGear 3'UTR luciferase reporter plasmid: SPIN1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPIN1 (see all 7) OriGene shRNA RFP: SPIN1 OriGene siRNA: SPIN1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPIN1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SPIN1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPIN1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPIN1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SPIN1 (NM_006717)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPIN1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPIN1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SPIN1
		Search LifeMap BioReagents cell lines for SPIN1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPIN1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0035064	methylated histone residue binding	IDA	--

SPIN1 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SPIN1

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

5/15 Interacting proteins for SPIN1 (Q9Y657^{2, 3} ENSP00000365019⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 15)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PTN	P21246²^,³	MINT-64750 I2D: score=4
AGO3	Q9H9G7³, ENSP00000362287⁴	I2D: score=2 STRING: ENSP00000362287
ARRB1	P49407³	I2D: score=1
ARRB2	P32121³	I2D: score=1
NAA38	ENSP00000249299⁴	STRING: ENSP00000249299

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007049	cell cycle	IEA	--
GO:0007275	multicellular organismal development	IEA	--
GO:0007276	gamete generation	IEA	--

SPIN1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SPIN1
Search CenterWatch for drugs/clinical trials and news about SPIN1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SPIN1 gene:

NM_006717.2

Unigene Cluster for SPIN1:

Spindlin 1

Hs.146804 [show with all ESTs]

Unigene Representative Sequence: NM_006717

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000375859(uc010mqj.3 uc004apy.3 uc004apz.3 uc010mqk.3)

ENST00000485804 ENST00000462844 ENST00000485565 ENST00000483785 ENST00000469017

ENST00000541629

miRNA Products:		OriGene 3'-UTR Clone: SPIN1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPIN1
		8/88 QIAGEN miScript miRNA Assays for microRNAs that regulate SPIN1 (see all 88):
		hsa-miR-124* hsa-miR-3678-3p hsa-miR-100* hsa-miR-607 hsa-miR-629 hsa-miR-4325 hsa-miR-489 hsa-miR-3613-3p

		SwitchGear 3'UTR luciferase reporter plasmid: SPIN1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPIN1 (see all 7) OriGene shRNA RFP: SPIN1 OriGene siRNA: SPIN1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPIN1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPIN1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPIN1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SPIN1 (NM_006717)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPIN1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPIN1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPIN1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat SPIN1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPIN1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPIN1

Additional cDNA sequence:

AF087864.1 AF106682.1 AF317228.2 AJ420427.1 AK024590.1 AK027044.1 AK092017.1 AK289691.1

AK290009.1 AK315854.1 AL136719.1 BC114515.1 BC114565.1 BT007314.1 CR533484.1

24 DOTS entries:

DT.100797415 DT.100797398 DT.118972 DT.100797394 DT.95097040 DT.100797416 DT.95354983 DT.100797419

DT.97855040 DT.121161252 DT.91762559 DT.99982992 DT.102833565 DT.121161237 DT.121161272 DT.121161311

DT.121161317 DT.121161327 DT.75141648 DT.91762549 DT.100797417 DT.100819189 DT.121161291 DT.92015963

24/433 AceView cDNA sequences (see all 433):

BQ774489 AA332788 AL045235 AI799316 CA308854 AW615078 BQ009386 CD679588

BX957158 AI689007 BT007314 AL541249 AI457572 Z41615 AA337558 F02450

H88245 AA461287 AF317228 AK024590 BQ425311 BF589334 BQ632665 AI457693

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SPIN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGCATTTGA

About this image

SPIN1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Early Embryo (Zygote)

Zygote

2-Cell Embryo

Early Embryo

Early Embryo (Zygote)

Early Embryo

Female Gametocytes, Germ Cells

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SPIN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPIN1

SOURCE GeneReport for Unigene cluster: Hs.146804

SABiosciences Custom PCR Arrays for SPIN1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPIN1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat SPIN1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPIN1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPIN1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPIN1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for SPIN1 gene from 5/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Spin1^{1 , 5}	spindlin 1^{1, 5}	93(n)¹ 99.24(a)¹		13 (26.04 cM)⁵ 20729¹ NM_146043.3¹ NP_666155.1¹ 51100898⁵
chicken (Gallus gallus)	Aves	SPINZ¹	spindlin 1	88.42(n) 96.56(a)		395344 NM_204633.1 NP_989964.1
lizard (Anolis carolinensis)	Reptilia	SPIN1⁶	--	96(a)	1 → many	2(37163227-37172835)
African clawed frog (Xenopus laevis)	Amphibia	Xl.20083²	Xenopus laevis transcribed sequence with strong similarity more	82.54(n)		BJ041975.1
zebrafish (Danio rerio)	Actinopterygii	LOC792822¹	spindlin-Z-like	75.57(n) 89.69(a)		792822 XM_001331747.2 XP_001331783.2

ENSEMBL Gene Tree for SPIN1 (if available)
TreeFam Gene Tree for SPIN1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SPIN1 gene

SPIN2B² SPIN2A² SPIN4² SPIN3²

4 SIMAP similar genes for SPIN1 using alignment to 1 protein entry: SPIN1_HUMAN:

SPIN3 SPIN2A SPIN4 SPIN2B

SPIN1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs140073265^1,2		--	91001439(+)	`AAGACA/GTTTTC`	1	--	us2k¹		0	--	--	--	--
rs7864964^1,2	C,F,A,	--	91001440(+)	`AGACGT/GTTTCC`	1	--	us2k¹ tfbs³		4		WA CSA	124
rs115150066^1,2	F,	--	91001468(+)	`GTGTGT/CGCTAC`	1	--	us2k¹		1		WA	118
rs143627243^1,2		--	91001470(+)	`GTGTGC/TTACTG`	1	--	us2k¹		0	--	--	--	--
rs186410361^1,2		--	91001546(+)	`TGAAAA/GGATTA`	1	--	us2k¹		0	--	--	--	--
rs73498070^1,2	C,	--	91001567(+)	`AAAGCC/TAACAC`	1	--	us2k¹		2		WA	120
rs190022292^1,2		--	91001592(+)	`AACCCA/GGGGAT`	1	--	us2k¹		0	--	--	--	--
rs7852530^1,2	C,	--	91001604(+)	`TCGCCA/GATGAG`	1	--	us2k¹		2		WA	120
rs146781318^1,2		--	91001679(+)	`GATGAC/TCCCAC`	1	--	us2k¹		0	--	--	--	--
rs7852802^1,2	C,	--	91001797(+)	`ggccaA/Gcatgg`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SPIN1 (91003297 - 91093623 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SPIN1
1 Indel: 70761

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPIN1

DNA2.0 Custom Variant and Variant Library Synthesis for SPIN1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SPIN1 for disorders           About GeneDecksing

OMIM gene information: 609936    OMIM disorders: --

1 disease for SPIN1:    About MalaCards

ovarian cancer

Human Genome Epidemiology (HuGE) Navigator: SPIN1 (1 document)

Export disorders for SPIN1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SPIN1 gene, integrated from 9 sources (see all 32):
(articles sorted by number of sources associating them with SPIN1)

Utopia: connect your pdf to the dynamic
world of online information

Spindlin1, a novel nuclear protein with a role in the transformation of NIH3T3 cells. (PubMed id 16098913)^{1, 2, 3} Gao Y.... Pei X. (2005)
Structure of human spindlin1. Tandem tudor-like domains for cell cycle regulation. (PubMed id 17082182)^{1, 2} Zhao Q....Rao Z. (2007)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2} Wiemann S.... Poustka A. (2001)
Biochemical and phosphoproteomic analysis of the helix -loop-helix protein E47. (PubMed id 22354994)¹ Teachenor R....Murre C. (2012)
Targeted ubiquitination and degradation of G-protein-c oupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)¹ Wu Z....Ma L. (2012)
SPINDLIN1 promotes cancer cell proliferation through a ctivation of WNT/TCF-4 signaling. (PubMed id 22258766)¹ Wang J.X....Pei X.T. (2012)
Distinct mode of methylated lysine-4 of histone H3 recognition by tandem tudor-like domains of Spindlin1. (PubMed id 23077255)¹ Yang N.... Xu R.M. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10927	HGNC: 11243	AceView: SPIN	Ensembl:ENSG00000106723	euGenes: HUgn10927
ECgene: SPIN1	H-InvDB: SPIN1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SPIN1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SPIN1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SPIN1 gene:
Search GeneIP for patents involving SPIN1

GeneCards and IP:
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPIN1

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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPIN1

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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spindlin 1

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SPIN1 Gene

spindlin 1

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