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SPIDR Gene

protein-coding   GIFtS: 34
GCID: GC08P048174

Scaffolding Protein Involved In DNA Repair

(Previous name: KIAA0146)
(Previous symbol: KIAA0146)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Scaffolding Protein Involved In DNA Repair1 2 3
KIAA01461 2 3 5
DNA Repair-Scaffolding Protein2

External Ids:    HGNC: 289711   Entrez Gene: 235142   Ensembl: ENSG000001648087   OMIM: 6153845   UniProtKB: Q141593   

Export aliases for SPIDR gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SPIDR Gene:
SPIDR (scaffolding protein involved in DNA repair) is a protein-coding gene.

UniProtKB/Swiss-Prot: SPIDR_HUMAN, Q14159
Function: Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a
scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and
recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for SPIDR
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SPIDR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPIDR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q11.21   Ensembl cytogenetic band:  8q11.21   HGNC cytogenetic band: 8q11.21

SPIDR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPIDR gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P048174:  view genomic region     (about GC identifiers)

Start:
48,173,167 bp from pter      End:
48,648,868 bp from pter
Size:
475,702 bases      Orientation:
plus strand

1 alternative location:
Chr8-,NT_113909 12,494-30,258     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SPIDR_HUMAN, Q14159 (See protein sequence)
Recommended Name: DNA repair-scaffolding protein  
Size: 915 amino acids; 100316 Da
Subunit: Found in a complex, at least composed of BLM, RAD51 and SPIDR; the complex formation is mediated by
SPIDR. Interacts (via C-terminus region) with BLM; the interaction is direct. Interacts with RAD51; the
interaction is direct. Interacts (via the C-terminus region) with FIGNL1 (via N-terminus one-half region); the
interaction is direct
Sequence caution: Sequence=BAA09767.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q96BI5

Explore the universe of human proteins at neXtProt for SPIDR: NX_Q14159

Explore proteomics data for SPIDR at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys346
  • Modification sites at PhosphoSitePlus

  • See SPIDR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001073863.1  NP_001269845.1  NP_001269848.1  

    ENSEMBL proteins: 
     ENSP00000297423   ENSP00000428222   ENSP00000429487   ENSP00000430965   ENSP00000430941  
     ENSP00000430664   ENSP00000428287   ENSP00000429997   ENSP00000429805   ENSP00000430091  
     ENSP00000429193   ENSP00000427889   ENSP00000427878   ENSP00000429448   ENSP00000444061  

    SPIDR Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for SPIDR
    OriGene Custom MassSpec
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SPIDR 

    SPIDR Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Search for Antibodies for SPIDR at Abcam
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    ThermoFisher Antibodies for SPIDR
    LSBio Antibodies in human, mouse, rat for SPIDR

    SPIDR Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for SPIDR 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR028032 DUF4503
     IPR028026 DUF4502

    Graphical View of Domain Structure for InterPro Entry Q14159

    ProtoNet protein and cluster: Q14159


    Find genes that share domains with SPIDR           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPIDR_HUMAN, Q14159
    Function: Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a
    scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and
    recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity
    Induction: Up-regulated in vascular endothelial cells treated with IL4. Up-regulated upon human SARS coronavirus
    infection

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with SPIDR           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SPIDR:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPIDR
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SPIDR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPIDR
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPIDR

    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SPIDR

    Gene Editing
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    Clone
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    Sino Biological Human cDNA Clone for SPIDR
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPIDR

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPIDR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPIDR_HUMAN, Q14159: Nucleus. Note=Together with BLM, is redistributed in discrete nuclear DNA damage-induced
    foci following hydroxyurea (HU) or camptothecin (CPT) treatment

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000228nuclear chromosome IDA--

    Find genes that share ontologies with SPIDR           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPIDR
    Interactions:

        Search GeneGlobe Interaction Network for SPIDR

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000724double-strand break repair via homologous recombination IMP--
    GO:0006974cellular response to DNA damage stimulus IDA--
    GO:0010569regulation of double-strand break repair via homologous recombination IDA--
    GO:0031334positive regulation of protein complex assembly IDA--
    GO:0070202regulation of establishment of protein localization to chromosome IDA--

    Find genes that share ontologies with SPIDR           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPIDR



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SPIDR gene (3 alternative transcripts): 
    NM_001080394.3  NM_001282916.1  NM_001282919.1  

    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):
    ENST00000297423(uc011lcz.2 uc011lda.2 uc003xqd.3 uc011ldc.2 uc011ldd.2 uc003xqe.3 uc010lxt.3 uc011ldf.2)
    ENST00000523814 ENST00000518074 ENST00000522900 ENST00000517824 ENST00000521550
    ENST00000524126 ENST00000522222 ENST00000519661 ENST00000524141(uc011ldb.2 uc010lxs.3 uc011lde.1)
    ENST00000524033 ENST00000522117 ENST00000524006 ENST00000521214(uc003xqf.3)
    ENST00000521798 ENST00000521918 ENST00000524157 ENST00000519401
    miRNA
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    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SPIDR
    Predesigned siRNA for gene silencing in human, mouse, rat SPIDR
    Clone
    Products:
         
    OriGene clones in human, mouse for SPIDR (see all 6)
    OriGene ORF clones in mouse, rat for SPIDR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for SPIDR
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPIDR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPIDR
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SPIDR
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat SPIDR
      QuantiTect SYBR Green Assays in human, mouse, rat SPIDR
      QuantiFast Probe-based Assays in human, mouse, rat SPIDR

    Selected AceView cDNA sequences (see all 774):

    AI631938 AI830696 AI341131 AW236007 AK092336 BE500986 BM128572 AI694005 
    AA045033 AI766886 BX376009 AI347518 BU932087 AI762201 AI470599 R68751 
    AI498925 AK026929 BE048559 BE219192 BE551862 AI912982 BI827346 AI431822 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SPIDR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SPIDR Expression
    About this image

    SPIDR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPIDR Protein Expression
        Custom PCR Arrays for SPIDR
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SPIDR
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat SPIDR
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    QuantiFast Probe-based Assays in human, mouse, rat SPIDR
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPIDR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SPIDR gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 2310008H04Rik5
    Spidr1
    RIKEN cDNA 2310008H04 gene5
    scaffolding protein involved i DNA repair1
    75.58(n)1
    66.15(a)1
      16 (10.09 cM)5
    2240081  NM_146068.41  NP_666180.21 
     158892275 
    chicken
    (Gallus gallus)
    Aves LOC4211061 KIAA0146 59.95(n)
    51.08(a)
      421106  XM_004939840.1  XP_004939897.1 
    lizard
    (Anolis carolinensis)
    Reptilia SPIDR6
    scaffolding protein involved in DNA repair
    35(a)
    1 ↔ 1
    GL343207.1(1684082-1892684)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia spidr1 scaffolding protein involved in DNA repair 54.28(n)
    44.83(a)
      100145029  NM_001142908.1  NP_001136380.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005350451 uncharacterized LOC100535045 49.13(n)
    40.04(a)
      100535045  XM_003201338.2  XP_003201386.2 


    ENSEMBL Gene Tree for SPIDR (if available)
    TreeFam Gene Tree for SPIDR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SPIDR (see all 7435)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs680186261,2
    C--43869109(+) CATTGGA/-GAGAG 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs1854656531,2
    --48171886(+) CTGTGG/TTGTCT 1 -- us2k10--------
    rs772246281,2
    C,F--48171952(+) GACATG/AGGTTA 1 -- us2k12Minor allele frequency- A:0.04WA EA 238
    rs1156264131,2
    C,F--48172112(+) CTGAGA/GTGGCG 1 -- us2k11Minor allele frequency- G:0.07WA 118
    rs795000541,2
    --48172359(+) CAACTA/CGATTG 1 -- us2k10--------
    rs78414671,2
    C--48172406(+) ATGGCA/TCTAGC 1 -- us2k14Minor allele frequency- T:0.05CSA WA EA 241
    rs1898339181,2
    --48172436(+) AAAGAC/TGGTTT 1 -- us2k10--------
    rs1825252841,2
    --48172467(+) CTGCAC/GAGTGG 1 -- us2k10--------
    rs1477556351,2
    C--48172493(+) CAAGTA/GTCTGC 1 -- us2k10--------
    rs1891300291,2
    --48172739(+) CTCCAC/TGGGAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SPIDR (48173167 - 48423167 bp, first 250kb of SPIDR)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SPIDR: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SPIDR
    DNA2.0 Custom Variant and Variant Library Synthesis for SPIDR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615384    OMIM disorders: --


    Find genes that share disorders with SPIDR           About GenesLikeMe


    Export disorders for SPIDR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SPIDR gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with SPIDR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair. (PubMed id 23509288)1, 2, 3 Wan L....Huang J. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    2. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280)1, 2, 3 Nagase T.... Nomura N. (DNA Res. 1995)
    3. FIGNL1-containing protein complex is required for efficient homologous recombination repair. (PubMed id 23754376)1, 2 Yuan J. and Chen J. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    4. Comparative host gene transcription by microarray analysis early after infection of the Huh7 cell line by severe acute respiratory syndrome coronavirus and human coronavirus 229E. (PubMed id 15858003)1, 2 Tang B.S.F....Yuen K.-Y. (J. Virol. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Gene expression profile in interleukin-4-stimulated human vascular endothelial cells. (PubMed id 15502879)1, 2 Lee Y.W.... Toborek M. (Mol. Med. 2004)
    7. Instability at the FRA8I common fragile site disrupts the genomic integrity of the KIAA0146, CEBPD and PRKDC genes in colorectal cancer. (PubMed id 23603433)1 Brueckner L.M....Savelyeva L. (Cancer Lett. 2013)
    8. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (PLoS Genet. 2012)
    9. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (Nature 2006)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23514 HGNC: 28971 AceView: KIAA0146 Ensembl:ENSG00000164808 euGenes: HUgn23514
    ECgene: SPIDR H-InvDB: SPIDR

    (According to HUGE)
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    HUGE: KIAA0146

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SPIDR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SPIDR gene:
    Search GeneIP for patents involving SPIDR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SPIDR  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SPIDR  
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     OriGene Custom Antibody Services for SPIDR   OriGene Custom Protein Services for SPIDR  

     
     
     Block miRNA regulation of human, mouse, rat SPIDR using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SPIDR
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPIDR Predesigned siRNA for gene silencing in human, mouse, rat SPIDR
     QuantiFast Probe-based Assays in human, mouse, rat SPIDR QuantiTect SYBR Green Assays in human, mouse, rat SPIDR
     Custom PCR Arrays for SPIDR Search Chromatin IP Primers for SPIDR
     Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat SPIDR Search GeneGlobe Interaction Network for SPIDR
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     GenScript Custom Purified and Recombinant Proteins Services for SPIDR GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for SPIDR
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     Search for Antibodies & Assays

     Search Tocris compounds for SPIDR
     Browse Sino Biological Proteins
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
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     Search for Antibodies for SPIDR at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SPIDR
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     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for SPIDR
     Gene Synthesis
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     Browse SwitchGear 3'UTR luciferase reporter plasmids for SPIDR
     Browse SwitchGear Promoter luciferase reporter plasmids for SPIDR
     ThermoFisher Antibodies for SPIDR
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPIDR
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPIDR
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SPIDR
     LSBio Antibodies in human, mouse, rat for SPIDR
    Customized transgenic rodents for:
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     Browse compounds at ApexBio
     Search Addgene for plasmids for SPIDR
      Search eBioscience for proteins for SPIDR
      Search eBioscience for elisas for SPIDR
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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