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SPICE1 Gene

protein-coding   GIFtS: 47
GCID: GC03M113162

Spindle And Centriole Associated Protein 1

(Previous name: coiled-coil domain containing 52)
(Previous symbol: CCDC52)
  Search for SPICE1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Spindle And Centriole Associated Protein 11 2     Coiled-Coil Domain-Containing Protein 522 3
CCDC521 2 3 5     SPICE2 3
Coiled-Coil Domain Containing 521 2     Spindle And Centriole-Associated Protein 12
Spindle And Centriole Protein1 2     Spindle And Centriole-Associated Protein3

External Ids:    HGNC: 250831   Entrez Gene: 1521852   Ensembl: ENSG000001636117   OMIM: 6134475   UniProtKB: Q8N0Z33   

Export aliases for SPICE1 gene to outside databases

Previous GC identifer: GC03M110536


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SPICE1 Gene:
SPICE1 (spindle and centriole associated protein 1) is a protein-coding gene.

UniProtKB/Swiss-Prot: SPICE_HUMAN, Q8N0Z3
Function: Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome
congression in mitosis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SPICE1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPICE1 promoter sequence
   Search Chromatin IP Primers for SPICE1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPICE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.2   Ensembl cytogenetic band:  3q13.2   HGNC cytogenetic band: 3q13.2

SPICE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPICE1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M113162:  view genomic region     (about GC identifiers)

Start:
113,161,565 bp from pter      End:
113,234,034 bp from pter
Size:
72,470 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SPICE_HUMAN, Q8N0Z3 (See protein sequence)
Recommended Name: Spindle and centriole-associated protein 1  
Size: 855 amino acids; 96264 Da
Subunit: Interacts with CEP120 (By similarity)
Secondary accessions: D3DN72 Q8WUX6

Explore the universe of human proteins at neXtProt for SPICE1: NX_Q8N0Z3

Explore proteomics data for SPICE1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys260, Lys546, Lys683, Lys744
  • Modification sites at PhosphoSitePlus

  • See SPICE1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_653319.1  
    ENSEMBL proteins: 
     ENSP00000295872   ENSP00000420363   ENSP00000417944   ENSP00000418681   ENSP00000417137  

    SPICE1 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SPICE1 

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    Abcam antibodies for SPICE1
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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for SPICE1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q8N0Z3


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPICE_HUMAN, Q8N0Z3
    Function: Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome
    congression in mitosis

    Animal Models:

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPICE1
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    miRNA
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    miRTarBase miRNAs that target SPICE1:
    hsa-mir-27a-3p (MIRT028713)

    Block miRNA regulation of human, mouse, rat SPICE1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SPICE1 (see all 21):
    hsa-miR-607 hsa-miR-3200-5p hsa-miR-495 hsa-miR-125a-3p hsa-miR-4251 hsa-miR-513a-5p hsa-miR-2115 hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmidSPICE1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SPICE1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: SPICE1 (NM_144718)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPICE1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPICE1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPICE_HUMAN, Q8N0Z3: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm,
    cytoskeleton, spindle
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus3
    cytosol1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005813centrosome IDA--
    GO:0005814centriole IDA--
    GO:0005819spindle IDA--

    Find genes that share ontologies with SPICE1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPICE1
    Interactions:

        Search GeneGlobe Interaction Network for SPICE1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for SPICE1 (Q8N0Z32, 3 ENSP000002958724) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ESRRAP114743, ENSP000000004424I2D: score=1 STRING: ENSP00000000442
    GSK3AP498403, ENSP000002223304I2D: score=1 STRING: ENSP00000222330
    GSK3BP498413, ENSP000003248064I2D: score=1 STRING: ENSP00000324806
    UBCENSP000003448184STRING: ENSP00000344818
    --Q9WMX22MINT-7049842
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046599regulation of centriole replication IMP--
    GO:0051310metaphase plate congression IMP--
    GO:0090307spindle assembly involved in mitosis IMP--

    Find genes that share ontologies with SPICE1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPICE1 (SPICE)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SPICE1 gene: 
    NM_144718.3  

    Unigene Cluster for SPICE1:

    Spindle and centriole associated protein 1
    Hs.477144  [show with all ESTs]
    Unigene Representative Sequence: NM_144718
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295872(uc003eaf.4 uc003eag.4) ENST00000467618 ENST00000496105(uc003eah.1)
    ENST00000495812 ENST00000480527 ENST00000460832(uc011bie.1 uc003eai.1)
    ENST00000496859
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SPICE1 (see all 21):
    hsa-miR-607 hsa-miR-3200-5p hsa-miR-495 hsa-miR-125a-3p hsa-miR-4251 hsa-miR-513a-5p hsa-miR-2115 hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmidSPICE1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SPICE1
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SPICE1 (NM_144718)
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    Primer
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    OriGene qPCR primer pairs and template standards for SPICE1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPICE1
      QuantiTect SYBR Green Assays in human, mouse, rat SPICE1
      QuantiFast Probe-based Assays in human, mouse, rat SPICE1

    Additional mRNA sequence: 

    AK026251.1 AK057966.1 AK126897.1 AK129575.1 AK296160.1 AL832148.1 AL832327.2 AY099107.1 
    BC019232.1 BC036951.1 BC038595.1 U79249.1 

    5 DOTS entries:

    DT.456202  DT.100745474  DT.95158257  DT.75108959  DT.75174179 

    Selected AceView cDNA sequences (see all 83):

    BF513868 AY099107 AI264430 AK129575 BG541539 AA805594 AA668779 AA465148 
    BM719204 BP341373 AL524841 CA430116 AW268461 AA161372 BX341057 AI921629 
    AW402739 Z44182 U79249 BF725648 BG399774 AL832327 AA355820 Z40161 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SPICE1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19
    SP1:                    -                             -                                                                             -                     
    SP2:                                                                                                                                                      
    SP3:              -     -                                                                                                                                 
    SP4:                                                                                                                                                      


    ECgene alternative splicing isoforms for SPICE1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SPICE1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SPICE1 Expression
    About this image

    SPICE1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPICE1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.477144
        Custom PCR Arrays for SPICE1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPICE1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SPICE1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spice11 , 5 spindle and centriole associated protein 11, 5 80.89(n)1
    77.67(a)1
      16 (28.67 cM)5
    2125141  NM_144550.41  NP_653133.31 
     443471215 
    chicken
    (Gallus gallus)
    Aves SPICE11 spindle and centriole associated protein 1 60.58(n)
    49.1(a)
      418322  XM_416545.4  XP_416545.4 
    lizard
    (Anolis carolinensis)
    Reptilia SPICE16
    spindle and centriole associated protein 1
    36(a)
    1 ↔ 1
    GL343473.1(154175-193417)
    African clawed frog
    (Xenopus laevis)
    Amphibia BU911647.12   -- 75.57(n)    BU911647.1 
    zebrafish
    (Danio rerio)
    Actinopterygii spice11 spindle and centriole associated protein 1 49.97(n)
    39.86(a)
      494093  NM_001008636.1  NP_001008636.1 


    ENSEMBL Gene Tree for SPICE1 (if available)
    TreeFam Gene Tree for SPICE1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SPICE1 (see all 1639)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs748986601,2
    C,F--113162370(+) ATAGGT/CCTACT 1 -- ut311Minor allele frequency- C:0.07WA 118
    rs1509101541,2
    --113162409(+) CCACAA/GCTTAT 1 -- ut310--------
    rs1857326461,2
    --113162449(+) ATAAGG/TAACAG 1 -- ut310--------
    rs1392416041,2
    --113162537(+) ATAGGC/TTTTGG 1 -- ut310--------
    rs119266871,2
    C,F,A,H--113162570(+) TTCTAA/GTGCCA 1 -- ut3119Minor allele frequency- G:0.09NS EA NA CSA WA 2348
    rs1442219551,2
    C--113162674(+) TGTCAC/TGAAGC 1 -- ut310--------
    rs119231281,2
    C,F,A,H--113162699(+) CAATAT/GTGCCT 1 -- ut3122Minor allele frequency- G:0.09NS EA NA CSA WA 2488
    rs1905447751,2
    --113162779(+) TTATAC/TGATAA 1 -- ut310--------
    rs67661861,2
    C,F,A,H--113162889(+) CTGGAG/AAAGTC 1 -- ut31 ese36Minor allele frequency- A:0.04NS EA CSA WA 538
    rs1465743471,2
    --113162925(+) AAACAC/TAAGTA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SPICE1 (113161565 - 113234034 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SPICE1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv237228CNV Loss16902084
    nsv509846CNV Loss20534489
    dgv5232n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SPICE1
    DNA2.0 Custom Variant and Variant Library Synthesis for SPICE1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613447    OMIM disorders: --


    Find genes that share disorders with SPICE1           About GenesLikeMe


    Export disorders for SPICE1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SPICE1 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with SPICE1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SPICE -- a previously uncharacterized protein required for centriole duplication and mitotic chromosome congression. (PubMed id 20736305)1, 2, 3 Archinti M.... Luders J. (J. Cell Sci. 2010)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. CEP120 and SPICE1 cooperate with CPAP in centriole elongation. (PubMed id 23810536)1 Comartin D....Pelletier L. (Curr. Biol. 2013)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (Nat. Genet. 2013)
    7. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    8. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 152185 HGNC: 25083 AceView: LOC152185 Ensembl:ENSG00000163611 euGenes: HUgn152185
    ECgene: SPICE1 H-InvDB: SPICE1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SPICE1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SPICE1 gene:
    Search GeneIP for patents involving SPICE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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