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Aliases for SPICE1 Gene

Aliases for SPICE1 Gene

  • Spindle And Centriole Associated Protein 1 2 3
  • CCDC52 3 4 6
  • Coiled-Coil Domain-Containing Protein 52 3 4
  • Coiled-Coil Domain Containing 52 2 3
  • Spindle And Centriole Protein 2 3
  • SPICE 3 4
  • Spindle And Centriole-Associated Protein 1 3
  • Spindle And Centriole-Associated Protein 4

External Ids for SPICE1 Gene

Previous HGNC Symbols for SPICE1 Gene

  • CCDC52

Previous GeneCards Identifiers for SPICE1 Gene

  • GC03M113162
  • GC03M110536

Summaries for SPICE1 Gene

GeneCards Summary for SPICE1 Gene

SPICE1 (Spindle And Centriole Associated Protein 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SPICE1 Gene

  • Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPICE1 Gene

Genomics for SPICE1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SPICE1 Gene

Start:
113,442,718 bp from pter
End:
113,515,187 bp from pter
Size:
72,470 bases
Orientation:
Minus strand

Genomic View for SPICE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPICE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPICE1 Gene

No data available for Regulatory Elements for SPICE1 Gene

Proteins for SPICE1 Gene

  • Protein details for SPICE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0Z3-SPICE_HUMAN
    Recommended name:
    Spindle and centriole-associated protein 1
    Protein Accession:
    Q8N0Z3
    Secondary Accessions:
    • D3DN72
    • Q8WUX6

    Protein attributes for SPICE1 Gene

    Size:
    855 amino acids
    Molecular mass:
    96264 Da
    Quaternary structure:
    • Interacts with CEP120.

neXtProt entry for SPICE1 Gene

Proteomics data for SPICE1 Gene at MOPED

Post-translational modifications for SPICE1 Gene

  • Ubiquitination at Lys260, Lys546, Lys683, and Lys744
  • Modification sites at PhosphoSitePlus

Other Protein References for SPICE1 Gene

No data available for DME Specific Peptides for SPICE1 Gene

Domains for SPICE1 Gene

Protein Domains for SPICE1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for SPICE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPICE1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SPICE1 Gene

Function for SPICE1 Gene

Molecular function for SPICE1 Gene

UniProtKB/Swiss-Prot Function: Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis.

Animal Model Products

CRISPR Products

miRNA for SPICE1 Gene

miRTarBase miRNAs that target SPICE1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SPICE1 Gene

Localization for SPICE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPICE1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPICE1 Gene COMPARTMENTS Subcellular localization image for SPICE1 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SPICE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA --
GO:0005814 centriole IDA 20736305
GO:0005819 spindle IDA 20736305
genes like me logo Genes that share ontologies with SPICE1: view

Pathways for SPICE1 Gene

SuperPathways for SPICE1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPICE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046599 regulation of centriole replication IMP 20736305
GO:0051301 cell division IEA --
GO:0051310 metaphase plate congression IMP 20736305
GO:0090307 mitotic spindle assembly IMP 20736305
genes like me logo Genes that share ontologies with SPICE1: view

No data available for Pathways by source for SPICE1 Gene

Transcripts for SPICE1 Gene

Unigene Clusters for SPICE1 Gene

Spindle and centriole associated protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPICE1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPICE1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19
SP1: - - -
SP2:
SP3: - -
SP4:

Relevant External Links for SPICE1 Gene

GeneLoc Exon Structure for
SPICE1
ECgene alternative splicing isoforms for
SPICE1

Expression for SPICE1 Gene

mRNA expression in normal human tissues for SPICE1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPICE1 Gene

SOURCE GeneReport for Unigene cluster for SPICE1 Gene Hs.477144

genes like me logo Genes that share expressions with SPICE1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SPICE1 Gene

Orthologs for SPICE1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPICE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPICE1 35
  • 99.42 (n)
  • 98.95 (a)
SPICE1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPICE1 35
  • 85.94 (n)
  • 81.79 (a)
SPICE1 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPICE1 35
  • 87.6 (n)
  • 82.51 (a)
SPICE1 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spice1 35
  • 80.89 (n)
  • 77.67 (a)
Spice1 16
Spice1 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPICE1 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPICE1 36
  • 46 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spice1 35
  • 81.37 (n)
  • 76.94 (a)
chicken
(Gallus gallus)
Aves SPICE1 35
  • 60.58 (n)
  • 49.1 (a)
SPICE1 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPICE1 36
  • 36 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spice1 35
  • 52.24 (n)
  • 42.3 (a)
zebrafish
(Danio rerio)
Actinopterygii spice1 35
  • 49.97 (n)
  • 39.86 (a)
spice1 36
  • 31 (a)
OneToOne
Species with no ortholog for SPICE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPICE1 Gene

ENSEMBL:
Gene Tree for SPICE1 (if available)
TreeFam:
Gene Tree for SPICE1 (if available)

Paralogs for SPICE1 Gene

No data available for Paralogs for SPICE1 Gene

Variants for SPICE1 Gene

Sequence variations from dbSNP and Humsavar for SPICE1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs629892 -- 113,459,178(+) AAGGG(A/C/G/T)AGTGC intron-variant, nc-transcript-variant
rs722392 -- 113,509,447(+) TAAAA(A/G)GTAGA intron-variant
rs869342 -- 113,507,483(+) AAGTA(C/T)TTTTT intron-variant
rs869343 -- 113,507,858(+) ACAAA(C/T)GAGAA intron-variant
rs1463639 -- 113,455,960(-) TTTAT(A/C)TTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPICE1 Gene

Variant ID Type Subtype PubMed ID
dgv5232n71 CNV Loss 21882294
nsv237228 CNV Loss 16902084
nsv509846 CNV Loss 20534489

Relevant External Links for SPICE1 Gene

HapMap Linkage Disequilibrium report
SPICE1
Human Gene Mutation Database (HGMD)
SPICE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPICE1 Gene

Disorders for SPICE1 Gene

No disorders were found for SPICE1 Gene.

No data available for UniProtKB/Swiss-Prot for SPICE1 Gene

Publications for SPICE1 Gene

  1. SPICE -- a previously uncharacterized protein required for centriole duplication and mitotic chromosome congression. (PMID: 20736305) Archinti M. … Luders J. (J. Cell Sci. 2010) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 3

Products for SPICE1 Gene

  • antibodies-online peptides for SPICE1
  • antibodies-online antibodies for SPICE1
  • antibodies-online kits for SPICE1

Sources for SPICE1 Gene

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