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Aliases for SPICE1 Gene

Aliases for SPICE1 Gene

  • Spindle And Centriole Associated Protein 1 2 3 5
  • Coiled-Coil Domain-Containing Protein 52 3 4
  • CCDC52 3 4
  • SPICE 3 4
  • Spindle And Centriole-Associated Protein 1 3
  • Spindle And Centriole-Associated Protein 4
  • Coiled-Coil Domain Containing 52 2
  • Spindle And Centriole Protein 2

External Ids for SPICE1 Gene

Previous HGNC Symbols for SPICE1 Gene

  • CCDC52

Previous GeneCards Identifiers for SPICE1 Gene

  • GC03M113162
  • GC03M110536

Summaries for SPICE1 Gene

GeneCards Summary for SPICE1 Gene

SPICE1 (Spindle And Centriole Associated Protein 1) is a Protein Coding gene. Diseases associated with SPICE1 include Occupational Dermatitis and Monkeypox.

UniProtKB/Swiss-Prot for SPICE1 Gene

  • Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis.

Additional gene information for SPICE1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPICE1 Gene

Genomics for SPICE1 Gene

Regulatory Elements for SPICE1 Gene

Enhancers for SPICE1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H114446 1.4 Ensembl ENCODE dbSUPER 26 -936.7 -936700 11 PKNOX1 BMI1 BATF ZNF23 ZNF366 ETV6 RUNX3 IKZF2 ZNF202 ZNF362 SPICE1 QTRT2 ENSG00000259976 USF3 ZBTB20-AS5 GC03P114568
GH03H112634 1.8 FANTOM5 Ensembl ENCODE dbSUPER 18.3 +875.6 875593 10 PKNOX1 ZNF133 SIN3A ZNF2 ZNF143 FOS RUNX3 DEK GTF2B REST SPICE1 NEPRO CD200R1 ENSG00000242770 C3orf52 MIR567 CCDC80 SLC35A5 LINC01279
GH03H113742 1.4 ENCODE dbSUPER 16.3 -231.1 -231109 8 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 ZNF143 NEPRO SPICE1 LOC101180897 CFAP44 BOC QTRT2 USF3 ATP6V1A NAA50 ENSG00000239280
GH03H112559 1.1 ENCODE 16.3 +953.6 953583 4 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 SLC35A5 NEPRO SPICE1 LOC101180897 CFAP44 BOC CCDC80 MIR567 C3orf52 ENSG00000279349
GH03H112615 1 ENCODE dbSUPER 16.3 +899.4 899352 1 BACH1 ZNF175 PYGO2 ZNF644 RELA IRF9 DIDO1 NFE2 ZNF639 RFX1 NEPRO SPICE1 LOC101180897 CFAP44 BOC CCDC80 LINC01279
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPICE1 on UCSC Golden Path with GeneCards custom track

Promoters for SPICE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000156705 87 2201 ATF1 ARID4B SIN3A ZNF2 ELK1 ATF7 RUNX3 SP5 MXD4 ZNF518A

Genomic Location for SPICE1 Gene

Chromosome:
3
Start:
113,442,718 bp from pter
End:
113,515,187 bp from pter
Size:
72,470 bases
Orientation:
Minus strand

Genomic View for SPICE1 Gene

Genes around SPICE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPICE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPICE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPICE1 Gene

Proteins for SPICE1 Gene

  • Protein details for SPICE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0Z3-SPICE_HUMAN
    Recommended name:
    Spindle and centriole-associated protein 1
    Protein Accession:
    Q8N0Z3
    Secondary Accessions:
    • D3DN72
    • Q8WUX6

    Protein attributes for SPICE1 Gene

    Size:
    855 amino acids
    Molecular mass:
    96264 Da
    Quaternary structure:
    • Interacts with CEP120.

neXtProt entry for SPICE1 Gene

Post-translational modifications for SPICE1 Gene

  • Ubiquitination at posLast=260260, posLast=546546, Lys683, and posLast=744744
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SPICE1 Gene

Domains & Families for SPICE1 Gene

Gene Families for SPICE1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPICE1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPICE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPICE1: view

No data available for UniProtKB/Swiss-Prot for SPICE1 Gene

Function for SPICE1 Gene

Molecular function for SPICE1 Gene

UniProtKB/Swiss-Prot Function:
Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis.

Phenotypes From GWAS Catalog for SPICE1 Gene

Gene Ontology (GO) - Molecular Function for SPICE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23455924
genes like me logo Genes that share ontologies with SPICE1: view

Phenotypes for SPICE1 Gene

genes like me logo Genes that share phenotypes with SPICE1: view

Animal Models for SPICE1 Gene

MGI Knock Outs for SPICE1:

Animal Model Products

CRISPR Products

miRNA for SPICE1 Gene

miRTarBase miRNAs that target SPICE1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SPICE1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPICE1 Gene

Localization for SPICE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPICE1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPICE1 gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 3
extracellular 2
mitochondrion 2
plasma membrane 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SPICE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
GO:0005814 centriole IDA,IEA 20736305
GO:0005819 spindle IEA,IDA 20736305
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with SPICE1: view

Pathways & Interactions for SPICE1 Gene

SuperPathways for SPICE1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPICE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0046599 regulation of centriole replication IMP 20736305
GO:0051301 cell division IEA --
GO:0051310 metaphase plate congression IMP 20736305
GO:0090307 mitotic spindle assembly IEA,IMP 20736305
genes like me logo Genes that share ontologies with SPICE1: view

No data available for Pathways by source and SIGNOR curated interactions for SPICE1 Gene

Drugs & Compounds for SPICE1 Gene

No Compound Related Data Available

Transcripts for SPICE1 Gene

Unigene Clusters for SPICE1 Gene

Spindle and centriole associated protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SPICE1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SPICE1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19
SP1: - - -
SP2:
SP3: - -
SP4:

Relevant External Links for SPICE1 Gene

GeneLoc Exon Structure for
SPICE1
ECgene alternative splicing isoforms for
SPICE1

Expression for SPICE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPICE1 Gene

Protein differential expression in normal tissues from HIPED for SPICE1 Gene

This gene is overexpressed in Heart (30.5), Fetal Brain (8.5), Lung (8.3), and Testis (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SPICE1 Gene



NURSA nuclear receptor signaling pathways regulating expression of SPICE1 Gene:

SPICE1

SOURCE GeneReport for Unigene cluster for SPICE1 Gene:

Hs.477144

Evidence on tissue expression from TISSUES for SPICE1 Gene

  • Nervous system(4.6)
  • Liver(2.6)
  • Intestine(2.4)
  • Stomach(2.4)
  • Blood(2.2)
  • Kidney(2.1)
  • Skin(2)
genes like me logo Genes that share expression patterns with SPICE1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPICE1 Gene

Orthologs for SPICE1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPICE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPICE1 33 34
  • 99.42 (n)
dog
(Canis familiaris)
Mammalia SPICE1 33 34
  • 87.6 (n)
cow
(Bos Taurus)
Mammalia SPICE1 33 34
  • 85.94 (n)
rat
(Rattus norvegicus)
Mammalia Spice1 33
  • 81.37 (n)
mouse
(Mus musculus)
Mammalia Spice1 33 16 34
  • 80.89 (n)
oppossum
(Monodelphis domestica)
Mammalia SPICE1 34
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPICE1 34
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPICE1 33 34
  • 60.58 (n)
lizard
(Anolis carolinensis)
Reptilia SPICE1 34
  • 36 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spice1 33
  • 52.24 (n)
zebrafish
(Danio rerio)
Actinopterygii spice1 33 34
  • 49.97 (n)
Species where no ortholog for SPICE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPICE1 Gene

ENSEMBL:
Gene Tree for SPICE1 (if available)
TreeFam:
Gene Tree for SPICE1 (if available)

Paralogs for SPICE1 Gene

No data available for Paralogs for SPICE1 Gene

Variants for SPICE1 Gene

Sequence variations from dbSNP and Humsavar for SPICE1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000041775 -- 113,454,993(+) TTATT(C/G)ATCCT intron-variant
rs1000064088 -- 113,495,050(+) CTGTG(C/T)TTAAA intron-variant
rs1000067093 -- 113,445,183(+) TTCAT(C/T)AGTAC intron-variant, nc-transcript-variant, utr-variant-3-prime, utr-variant-5-prime
rs1000074581 -- 113,454,765(+) TGACT(G/T)TATCA intron-variant
rs1000081788 -- 113,487,379(+) AAATA(A/G)ACAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPICE1 Gene

Variant ID Type Subtype PubMed ID
esv3597439 CNV loss 21293372
nsv1013506 CNV gain 25217958
nsv1124874 CNV duplication 24896259
nsv237228 CNV deletion 16902084
nsv509846 OTHER sequence alteration 20534489

Variation tolerance for SPICE1 Gene

Residual Variation Intolerance Score: 51.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.51; 64.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPICE1 Gene

Human Gene Mutation Database (HGMD)
SPICE1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPICE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPICE1 Gene

Disorders for SPICE1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SPICE1 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
occupational dermatitis
  • occupational allergic contact dermatitis
monkeypox
  • monkeypox virus infection
variola minor
  • alastrim
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SPICE1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPICE1
genes like me logo Genes that share disorders with SPICE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPICE1 Gene

Publications for SPICE1 Gene

  1. SPICE--a previously uncharacterized protein required for centriole duplication and mitotic chromosome congression. (PMID: 20736305) Archinti M … Lüders J (Journal of cell science 2010) 2 3 4 60
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. (PMID: 27880917) St-Denis N … Gingras AC (Cell reports 2016) 3 60

Products for SPICE1 Gene

Sources for SPICE1 Gene

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