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Aliases for SPICE1 Gene

Aliases for SPICE1 Gene

  • Spindle And Centriole Associated Protein 1 2 3 5
  • Coiled-Coil Domain-Containing Protein 52 3 4
  • Coiled-Coil Domain Containing 52 2 3
  • Spindle And Centriole Protein 2 3
  • CCDC52 3 4
  • SPICE 3 4
  • Spindle And Centriole-Associated Protein 4

External Ids for SPICE1 Gene

Previous HGNC Symbols for SPICE1 Gene

  • CCDC52

Previous GeneCards Identifiers for SPICE1 Gene

  • GC03M113162
  • GC03M110536

Summaries for SPICE1 Gene

GeneCards Summary for SPICE1 Gene

SPICE1 (Spindle And Centriole Associated Protein 1) is a Protein Coding gene. Diseases associated with SPICE1 include occupational dermatitis and variola minor.

UniProtKB/Swiss-Prot for SPICE1 Gene

  • Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPICE1 Gene

Genomics for SPICE1 Gene

Regulatory Elements for SPICE1 Gene

Promoters for SPICE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SPICE1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPICE1 Gene

Chromosome:
3
Start:
113,442,718 bp from pter
End:
113,515,187 bp from pter
Size:
72,470 bases
Orientation:
Minus strand

Genomic View for SPICE1 Gene

Genes around SPICE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPICE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPICE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPICE1 Gene

Proteins for SPICE1 Gene

  • Protein details for SPICE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0Z3-SPICE_HUMAN
    Recommended name:
    Spindle and centriole-associated protein 1
    Protein Accession:
    Q8N0Z3
    Secondary Accessions:
    • D3DN72
    • Q8WUX6

    Protein attributes for SPICE1 Gene

    Size:
    855 amino acids
    Molecular mass:
    96264 Da
    Quaternary structure:
    • Interacts with CEP120.

neXtProt entry for SPICE1 Gene

Proteomics data for SPICE1 Gene at MOPED

Post-translational modifications for SPICE1 Gene

  • Ubiquitination at Lys 260, Lys 546, Lys 683, and Lys 744
  • Modification sites at PhosphoSitePlus

Other Protein References for SPICE1 Gene

No data available for DME Specific Peptides for SPICE1 Gene

Domains & Families for SPICE1 Gene

Protein Domains for SPICE1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPICE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPICE1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SPICE1 Gene

Function for SPICE1 Gene

Molecular function for SPICE1 Gene

UniProtKB/Swiss-Prot Function:
Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis.

Phenotypes for SPICE1 Gene

GenomeRNAi human phenotypes for SPICE1:
genes like me logo Genes that share phenotypes with SPICE1: view

Animal Model Products

CRISPR Products

miRNA for SPICE1 Gene

miRTarBase miRNAs that target SPICE1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPICE1 Gene

Localization for SPICE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPICE1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPICE1 Gene COMPARTMENTS Subcellular localization image for SPICE1 gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 3
extracellular 2
mitochondrion 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SPICE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005819 spindle IDA 20736305
genes like me logo Genes that share ontologies with SPICE1: view

Pathways & Interactions for SPICE1 Gene

SuperPathways for SPICE1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPICE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090307 mitotic spindle assembly IEA,IMP 20736305
genes like me logo Genes that share ontologies with SPICE1: view

No data available for Pathways by source and SIGNOR curated interactions for SPICE1 Gene

Drugs & Compounds for SPICE1 Gene

No Compound Related Data Available

Transcripts for SPICE1 Gene

Unigene Clusters for SPICE1 Gene

Spindle and centriole associated protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPICE1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19
SP1: - - -
SP2:
SP3: - -
SP4:

Relevant External Links for SPICE1 Gene

GeneLoc Exon Structure for
SPICE1
ECgene alternative splicing isoforms for
SPICE1

Expression for SPICE1 Gene

mRNA expression in normal human tissues for SPICE1 Gene

Protein differential expression in normal tissues from HIPED for SPICE1 Gene

This gene is overexpressed in Heart (30.5), Fetal Brain (8.5), Lung (8.3), and Testis (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPICE1 Gene



SOURCE GeneReport for Unigene cluster for SPICE1 Gene Hs.477144

genes like me logo Genes that share expression patterns with SPICE1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SPICE1 Gene

Orthologs for SPICE1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPICE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPICE1 35
  • 99.42 (n)
  • 98.95 (a)
SPICE1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPICE1 36
  • 80 (a)
OneToOne
SPICE1 35
  • 85.94 (n)
  • 81.79 (a)
dog
(Canis familiaris)
Mammalia SPICE1 35
  • 87.6 (n)
  • 82.51 (a)
SPICE1 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spice1 16
Spice1 36
  • 77 (a)
OneToOne
Spice1 35
  • 80.89 (n)
  • 77.67 (a)
oppossum
(Monodelphis domestica)
Mammalia SPICE1 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPICE1 36
  • 46 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spice1 35
  • 81.37 (n)
  • 76.94 (a)
chicken
(Gallus gallus)
Aves SPICE1 35
  • 60.58 (n)
  • 49.1 (a)
SPICE1 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPICE1 36
  • 36 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spice1 35
  • 52.24 (n)
  • 42.3 (a)
zebrafish
(Danio rerio)
Actinopterygii spice1 36
  • 31 (a)
OneToOne
spice1 35
  • 49.97 (n)
  • 39.86 (a)
Species with no ortholog for SPICE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPICE1 Gene

ENSEMBL:
Gene Tree for SPICE1 (if available)
TreeFam:
Gene Tree for SPICE1 (if available)

Paralogs for SPICE1 Gene

No data available for Paralogs for SPICE1 Gene

Variants for SPICE1 Gene

Sequence variations from dbSNP and Humsavar for SPICE1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs16861032 - 113,468,828(+) GTCTA(C/G)AGTCT reference, missense
rs7614751 - 113,460,638(+) TCTTC(C/T)ACCTG reference, missense
rs1486894 -- 113,492,666(+) TTTTC(A/G)CACCT intron-variant
rs1486897 -- 113,496,971(+) TGACA(A/G)TACTA intron-variant
rs1463643 -- 113,496,600(+) TTCCC(A/G)TGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPICE1 Gene

Variant ID Type Subtype PubMed ID
dgv5232n71 CNV Loss 21882294
nsv237228 CNV Loss 16902084
nsv509846 CNV Loss 20534489

Variation tolerance for SPICE1 Gene

Residual Variation Intolerance Score: 51.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.51; 64.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPICE1 Gene

HapMap Linkage Disequilibrium report
SPICE1
Human Gene Mutation Database (HGMD)
SPICE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPICE1 Gene

Disorders for SPICE1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SPICE1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
occupational dermatitis
  • occupational allergic contact dermatitis
variola minor
  • alastrim
monkeypox
  • monkeypox virus infection
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SPICE1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPICE1
genes like me logo Genes that share disorders with SPICE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPICE1 Gene

Publications for SPICE1 Gene

  1. SPICE -- a previously uncharacterized protein required for centriole duplication and mitotic chromosome congression. (PMID: 20736305) Archinti M. … Luders J. (J. Cell Sci. 2010) 2 3 4 67
  2. Proximity Interactions among Centrosome Components Identify Regulators of Centriole Duplication. (PMID: 24613305) Firat-Karalar E.N. … Stearns T. (Curr. Biol. 2014) 3
  3. LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. (PMID: 23443559) Fogeron M.L. … Lange B.M. (Nat Commun 2013) 3
  4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3
  5. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 3

Products for SPICE1 Gene

Sources for SPICE1 Gene

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