Aliases for SPIC Gene
Aliases for SPIC Gene
External Ids for SPIC Gene
- HGNC: 29549
- Entrez Gene: 121599
- Ensembl: ENSG00000166211
- OMIM: 612568
- UniProtKB: Q8N5J4
Previous GeneCards Identifiers for SPIC Gene
- GC12P101853
- GC12P100371
- GC12P100393
- GC12P101870
- GC12P098930
Summaries for SPIC Gene
-
The protein encoded by this gene regulates the development of red pulp macrophages, which are necessary for iron homeostasis and the recycling of red blood cells. [provided by RefSeq, Aug 2016]
GeneCards Summary for SPIC Gene
SPIC (Spi-C Transcription Factor) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is SPI1.
UniProtKB/Swiss-Prot for SPIC Gene
-
Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5-GAGGA[AT]-3) that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity).
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPIC Gene
Genomics for SPIC Gene
Regulatory Elements for SPIC Gene
Enhancers for SPIC Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH12G101582 | 0.6 | ENCODE dbSUPER | 10.5 | +108.5 | 108526 | 2.7 | SIX4 | CHPT1 SPIC RNA5SP367 RNU5E-5P SYCP3 ARL1 RNU6-101P MYBPC1 LOC105369938 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around SPIC on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for SPIC Gene
- Chromosome:
- 12
- Start:
- 101,475,323 bp from pter
- End:
- 101,487,566 bp from pter
- Size:
- 12,244 bases
- Orientation:
- Plus strand
Genomic View for SPIC Gene
Genes around SPIC on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q23.2 by Ensembl
- 12q23.2 by Entrez Gene
- 12q23.2 by HGNC
SPIC Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SPIC Gene
Proteins for SPIC Gene
-
Protein details for SPIC Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N5J4-SPIC_HUMAN
- Recommended name:
- Transcription factor Spi-C
- Protein Accession:
- Q8N5J4
Protein attributes for SPIC Gene
- Size:
- 248 amino acids
- Molecular mass:
- 29180 Da
- Quaternary structure:
-
- Binds DNA as a monomer.
Protein Expression for SPIC Gene
Post-translational modifications for SPIC Gene
Other Protein References for SPIC Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for SPIC
- Invitrogen Antibodies for SPIC
- antibodies-online Antibodies for SPIC: See all 26
- GeneTex SPIC antibody for SPIC
-
Santa Cruz Biotechnology (SCBT) Antibodies for SPIC
Protein Products
-
OriGene Purified Proteins for SPIC
- Search Origene for MassSpec and Protein Over-expression Lysates for SPIC
- Origene Custom Protein Services for SPIC
- antibodies-online Proteins for SPIC: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for SPIC
Assay Products
- antibodies-online Kits for SPIC: See all 13
No data available for DME Specific Peptides for SPIC Gene
Domains & Families for SPIC Gene
Gene Families for SPIC Gene
Protein Domains for SPIC Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SPIC Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8N5J4- Family:
-
- Belongs to the ETS family.
Function for SPIC Gene
Molecular function for SPIC Gene
- UniProtKB/Swiss-Prot Function:
- Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5-GAGGA[AT]-3) that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | IEA | -- |
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | IBA | -- |
| GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | IEA | -- |
Phenotypes for SPIC Gene
- MGI mutant phenotypes for SPIC:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for SPIC:
Animal Models for SPIC Gene
- MGI Knock Outs for SPIC:
-
- Spic tm1.1Kmm
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SPIC
-
-
ViGene Biosciences lentiviral particle packaged cDNA for SPIC gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SPIC gene
- Search ViGene Biosciences for SPIC
CRISPR Products
-
OriGene CRISPR knockouts for SPIC
-
Applied Biological Materials CRISPR for SPIC
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPIC
- GenScript: Design CRISPR guide RNA sequences for SPIC
miRNA for SPIC Gene
- miRTarBase miRNAs that target SPIC
-
- hsa-mir-335-5p (MIRT018368)
- hsa-mir-6885-3p (MIRT525468)
- hsa-mir-1238-3p (MIRT525469)
- hsa-mir-670-3p (MIRT525470)
- hsa-mir-6881-3p (MIRT525471)
- hsa-mir-6780a-3p (MIRT525472)
- hsa-mir-7111-3p (MIRT525473)
- hsa-mir-4775 (MIRT525474)
- hsa-mir-877-3p (MIRT525475)
- hsa-mir-5590-3p (MIRT525476)
- hsa-mir-142-5p (MIRT525477)
- hsa-mir-561-3p (MIRT525478)
- hsa-mir-548at-5p (MIRT525479)
- hsa-mir-4668-5p (MIRT617249)
- hsa-mir-3613-3p (MIRT617250)
- hsa-mir-382-5p (MIRT617251)
- hsa-mir-495-5p (MIRT617252)
- hsa-mir-590-3p (MIRT640289)
- hsa-mir-498 (MIRT678010)
- hsa-mir-6778-3p (MIRT678011)
- hsa-mir-4279 (MIRT678012)
- hsa-mir-5186 (MIRT678013)
- hsa-mir-1976 (MIRT678014)
- hsa-mir-3653-5p (MIRT678015)
- hsa-mir-150-5p (MIRT678016)
- hsa-mir-6747-3p (MIRT678017)
- hsa-mir-6727-3p (MIRT678018)
- hsa-mir-4722-3p (MIRT678019)
- hsa-mir-6814-5p (MIRT678020)
- hsa-mir-5697 (MIRT678021)
- hsa-mir-562 (MIRT678022)
miRNA Products
- Search ViGene Biosciences for SPIC
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for SPIC
- Browse OriGene Inhibitory RNA Products For SPIC
-
ViGene Biosciences ready-to-package AAV shRNAs for SPIC gene
Clone Products
- Sino Biological Human cDNA Clone for SPIC
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SPIC
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SPIC
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for SPIC
-
ViGene Biosciences adenoviral particle packaged cDNA for SPIC gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SPIC gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SPIC gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPIC Gene
Localization for SPIC Gene
Subcellular locations from UniProtKB/Swiss-Prot for SPIC Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| endosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA,IEA | -- |
Pathways & Interactions for SPIC Gene
No Data Available
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001824 | blastocyst development | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription from RNA polymerase II promoter | IBA | -- |
| GO:0006366 | transcription from RNA polymerase II promoter | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for SPIC Gene
Transcripts for SPIC Gene
mRNA/cDNA for SPIC Gene
- (3) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (7) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SPIC Gene
CRISPR Products
-
OriGene CRISPR knockouts for SPIC
-
Applied Biological Materials CRISPR for SPIC
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPIC
- GenScript: Design CRISPR guide RNA sequences for SPIC
miRNA Products
- Search ViGene Biosciences for SPIC
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for SPIC
- Browse OriGene Inhibitory RNA Products For SPIC
-
ViGene Biosciences ready-to-package AAV shRNAs for SPIC gene
Clone Products
- Sino Biological Human cDNA Clone for SPIC
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SPIC
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SPIC
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for SPIC Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
-
Heart (Cardiovascular System)
- Mature Cardiac Fibroblasts Myocardium
-
Fibroblasts
- Mature Cardiac Fibroblasts Myocardium
- Liver (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for SPIC Gene
This gene is overexpressed in Spleen (x49.3).
This gene is overexpressed in Heart (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPIC Gene
NURSA nuclear receptor signaling pathways regulating expression of SPIC Gene:
SPICSOURCE GeneReport for Unigene cluster for SPIC Gene:
Hs.577097mRNA Expression by UniProt/SwissProt for SPIC Gene:
Q8N5J4-SPIC_HUMAN
Tissue specificity:
Preferentially detected in fetal and adult spleen, lymph nodes and at lower levels in bone marrow and fetal liver.
Evidence on tissue expression from TISSUES for SPIC Gene
- Pancreas(4)
- Spleen(2.5)
Primer Products
-
OriGene qPCR primer pairs and template standards for SPIC
-
OriGene qPCR primer pairs for SPIC
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SPIC Gene
Orthologs for SPIC Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SPIC 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | SPIC 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | SPIC 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Spic 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Spic 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | SPIC 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | SPIC 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | SPIC 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | SPIC 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | spic 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | spic 34 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for SPIC was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for SPIC Gene
(3) SIMAP similar genes for SPIC Gene using alignment to 1 proteins:
Pseudogenes.org Pseudogenes for SPIC Gene
Variants for SPIC Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000266836 | -- | 101,478,343(+) | TTATC(-/TTTAA)TTTAA | intron-variant | |
| rs1000468963 | -- | 101,485,299(+) | CTTTT(G/T)TTCTC | intron-variant | |
| rs1000496178 | -- | 101,480,449(+) | TTCAT(C/T)GATAT | intron-variant | |
| rs1000597179 | -- | 101,486,258(+) | TTTAA(A/T)TCAGT | intron-variant | |
| rs1000632210 | -- | 101,480,182(+) | ACATG(C/T)TGTTA | intron-variant |
Residual Variation Intolerance Score:
78.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.85;
58.76% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for SPIC Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SPIC
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPIC Gene
Disorders for SPIC Gene
Relevant External Links for SPIC
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- SPIC
No disorders were found for SPIC Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPIC Gene
Publications for SPIC Gene
- Genomic structure of mouse SPI-C and genomic structure and expression pattern of human SPI-C. (PMID: 12459275) Carlsson R. … Leanderson T. (Gene 2002) 2 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases. (PMID: 24709693) Cobb J. … Thomson W. (Pharmacogenomics J. 2014) 3 64
- Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64
- SPI-C and STAT6 can cooperate to stimulate IgE germline transcription. (PMID: 16647686) Carlsson R. … Leanderson T. (Biochem. Biophys. Res. Commun. 2006) 3 64
Products for SPIC Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for SPIC
- Search Origene for MassSpec and Protein Over-expression Lysates for SPIC
- Origene Custom Protein Services for SPIC
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for SPIC
- Browse OriGene Inhibitory RNA Products For SPIC
- OriGene qPCR primer pairs and template standards for SPIC
- OriGene qPCR primer pairs for SPIC
- OriGene CRISPR knockouts for SPIC
- OriGene ORF clones in human for SPIC
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SPIC
- GenScript: Next-day shipping of latest version cDNA ORF clones for SPIC in any vector
- GenScript Custom Purified and Recombinant Proteins Services for SPIC
- GenScript Custom Assay Services for SPIC
- GenScript Custom overexpressing Cell Line Services for SPIC
- GenScript: Design CRISPR guide RNA sequences for SPIC
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for SPIC
- Sino Biological Human cDNA Clone for SPIC
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for SPIC
- Novus Biologicals proteins and lysates for SPIC
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for SPIC
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- antibodies-online Antibodies for SPIC: See all 26
- antibodies-online Kits for SPIC: See all 13
- antibodies-online Proteins for SPIC: See all 5
- Search antibodies-online for peptides
- GeneTex SPIC antibody for SPIC
- Search GeneTex for Proteins for SPIC
- ViGene Biosciences adenoviral particle packaged cDNA for SPIC gene
- ViGene Biosciences lentiviral particle packaged cDNA for SPIC gene
- ViGene Biosciences ready-to-package AAV shRNAs for SPIC gene
- Search ViGene Biosciences for SPIC
- Santa Cruz Biotechnology (SCBT) Antibodies for SPIC
- Search Santa Cruz Biotechnology (SCBT) for SPIC siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SPIC
- Horizon Cell Lines for SPIC
- Cyagen custom Knockout/knockin (KOKI) mouse models for SPIC
- VectorBuilder custom plasmid, inducible vectors for SPIC
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SPIC
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for SPIC Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus Biologicals
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer
- (156) abm
- (157) CrownBio