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Aliases for SPIC Gene

Aliases for SPIC Gene

  • Spi-C Transcription Factor 2 3 5
  • Spi-C Transcription Factor (Spi-1/PU.1 Related) 2 3
  • Transcription Factor Spi-C 3
  • SPI-C 3

External Ids for SPIC Gene

Previous GeneCards Identifiers for SPIC Gene

  • GC12P101853
  • GC12P100371
  • GC12P100393
  • GC12P101870
  • GC12P098930

Summaries for SPIC Gene

Entrez Gene Summary for SPIC Gene

  • The protein encoded by this gene regulates the development of red pulp macrophages, which are necessary for iron homeostasis and the recycling of red blood cells. [provided by RefSeq, Aug 2016]

GeneCards Summary for SPIC Gene

SPIC (Spi-C Transcription Factor) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is SPI1.

UniProtKB/Swiss-Prot for SPIC Gene

  • Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5-GAGGA[AT]-3) that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPIC Gene

Genomics for SPIC Gene

Regulatory Elements for SPIC Gene

Enhancers for SPIC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F101582 0.2 ENCODE 10.5 +108.5 108526 2.7 SIX4 CHPT1 SPIC RNA5SP367 RNU5E-5P SYCP3 ARL1 RNU6-101P MYBPC1 LOC105369938
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SPIC on UCSC Golden Path with GeneCards custom track

Genomic Location for SPIC Gene

Chromosome:
12
Start:
101,475,323 bp from pter
End:
101,487,566 bp from pter
Size:
12,244 bases
Orientation:
Plus strand

Genomic View for SPIC Gene

Genes around SPIC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPIC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPIC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPIC Gene

Proteins for SPIC Gene

  • Protein details for SPIC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5J4-SPIC_HUMAN
    Recommended name:
    Transcription factor Spi-C
    Protein Accession:
    Q8N5J4

    Protein attributes for SPIC Gene

    Size:
    248 amino acids
    Molecular mass:
    29180 Da
    Quaternary structure:
    • Binds DNA as a monomer.

neXtProt entry for SPIC Gene

Post-translational modifications for SPIC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPIC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPIC Gene

Domains & Families for SPIC Gene

Gene Families for SPIC Gene

Protein Domains for SPIC Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPIC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N5J4

UniProtKB/Swiss-Prot:

SPIC_HUMAN :
  • Contains 1 ETS DNA-binding domain.
  • Belongs to the ETS family.
Domain:
  • Contains 1 ETS DNA-binding domain.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with SPIC: view

Function for SPIC Gene

Molecular function for SPIC Gene

UniProtKB/Swiss-Prot Function:
Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5-GAGGA[AT]-3) that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity).

Gene Ontology (GO) - Molecular Function for SPIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with SPIC: view
genes like me logo Genes that share phenotypes with SPIC: view

Animal Models for SPIC Gene

MGI Knock Outs for SPIC:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPIC Gene

Localization for SPIC Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPIC Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPIC Gene COMPARTMENTS Subcellular localization image for SPIC gene
Compartment Confidence
nucleus 5
cytosol 2
endosome 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SPIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
genes like me logo Genes that share ontologies with SPIC: view

Pathways & Interactions for SPIC Gene

SuperPathways for SPIC Gene

No Data Available

Interacting Proteins for SPIC Gene

Selected Interacting proteins: Q8N5J4-SPIC_HUMAN for SPIC Gene via IID

Gene Ontology (GO) - Biological Process for SPIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001824 blastocyst development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with SPIC: view

No data available for Pathways by source and SIGNOR curated interactions for SPIC Gene

Transcripts for SPIC Gene

mRNA/cDNA for SPIC Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPIC Gene

Spi-C transcription factor (Spi-1/PU.1 related):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPIC Gene

No ASD Table

Relevant External Links for SPIC Gene

GeneLoc Exon Structure for
SPIC
ECgene alternative splicing isoforms for
SPIC

Expression for SPIC Gene

mRNA expression in normal human tissues for SPIC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPIC Gene

This gene is overexpressed in Spleen (x49.3).

Protein differential expression in normal tissues from HIPED for SPIC Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPIC Gene



Protein tissue co-expression partners for SPIC Gene

NURSA nuclear receptor signaling pathways regulating expression of SPIC Gene:

SPIC

SOURCE GeneReport for Unigene cluster for SPIC Gene:

Hs.577097

mRNA Expression by UniProt/SwissProt for SPIC Gene:

Q8N5J4-SPIC_HUMAN
Tissue specificity: Preferentially detected in fetal and adult spleen, lymph nodes and at lower levels in bone marrow and fetal liver.
genes like me logo Genes that share expression patterns with SPIC: view

Primer Products

Orthologs for SPIC Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPIC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPIC 34 35
  • 99.73 (n)
cow
(Bos Taurus)
Mammalia SPIC 34 35
  • 90.99 (n)
dog
(Canis familiaris)
Mammalia SPIC 34 35
  • 89.88 (n)
rat
(Rattus norvegicus)
Mammalia Spic 34
  • 80.35 (n)
mouse
(Mus musculus)
Mammalia Spic 34 16 35
  • 77.73 (n)
oppossum
(Monodelphis domestica)
Mammalia SPIC 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPIC 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPIC 34 35
  • 70.57 (n)
lizard
(Anolis carolinensis)
Reptilia SPIC 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spic 34
  • 64.89 (n)
zebrafish
(Danio rerio)
Actinopterygii spic 34 35
  • 53.06 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 15 (a)
OneToMany
Species where no ortholog for SPIC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPIC Gene

ENSEMBL:
Gene Tree for SPIC (if available)
TreeFam:
Gene Tree for SPIC (if available)

Paralogs for SPIC Gene

Paralogs for SPIC Gene

(3) SIMAP similar genes for SPIC Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPIC: view

Variants for SPIC Gene

Sequence variations from dbSNP and Humsavar for SPIC Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10083016 -- 101,475,735(+) AATAT(G/T)TAATT intron-variant
rs10683589 -- 101,479,834(+) TTTTT(-/T)GAGAT intron-variant
rs10778120 -- 101,481,363(+) TAAAT(A/T)TAAAT intron-variant
rs10860738 -- 101,474,219(+) GATCT(A/G)CATAT upstream-variant-2KB
rs10860739 -- 101,477,986(+) TCCAG(A/G)ATAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPIC Gene

Variant ID Type Subtype PubMed ID
dgv86e215 CNV deletion 23714750
nsv1113514 CNV deletion 24896259
nsv507669 OTHER sequence alteration 20534489
nsv973109 CNV duplication 23825009

Variation tolerance for SPIC Gene

Residual Variation Intolerance Score: 78.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.85; 58.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPIC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPIC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPIC Gene

Disorders for SPIC Gene

Relevant External Links for SPIC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPIC

No disorders were found for SPIC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPIC Gene

Publications for SPIC Gene

  1. Genomic structure of mouse SPI-C and genomic structure and expression pattern of human SPI-C. (PMID: 12459275) Carlsson R. … Leanderson T. (Gene 2002) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases. (PMID: 24709693) Cobb J. … Thomson W. (Pharmacogenomics J. 2014) 3 64
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64
  5. SPI-C and STAT6 can cooperate to stimulate IgE germline transcription. (PMID: 16647686) Carlsson R. … Leanderson T. (Biochem. Biophys. Res. Commun. 2006) 3 64

Products for SPIC Gene

Sources for SPIC Gene

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