Aliases for SPIC Gene
External Ids for SPIC Gene
Previous GeneCards Identifiers for SPIC Gene
The protein encoded by this gene regulates the development of red pulp macrophages, which are necessary for iron homeostasis and the recycling of red blood cells. [provided by RefSeq, Aug 2016]
GeneCards Summary for SPIC Gene
SPIC (Spi-C Transcription Factor) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is SPI1.
UniProtKB/Swiss-Prot for SPIC Gene
Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5-GAGGA[AT]-3) that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity).