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SPIC Gene

protein-coding   GIFtS: 47
GCID: GC12P101870

Spi-C Transcription Factor (Spi-1/PU.1 Related)

  See SPIC-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Spi-C Transcription Factor (Spi-1/PU.1 Related)1 2
SPI-C2
Transcription Factor Spi-C2

External Ids:    HGNC: 295491   Entrez Gene: 1215992   Ensembl: ENSG000001662117   OMIM: 6125685   UniProtKB: Q8N5J43   

Export aliases for SPIC gene to outside databases

Previous GC identifers: GC12P101853 GC12P100371 GC12P100393 GC12P098930


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SPIC Gene:
SPIC (Spi-C transcription factor (Spi-1/PU.1 related)) is a protein-coding gene. Diseases associated with SPIC include wolman disease, and lipomatosis. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ENSG00000142539.

UniProtKB/Swiss-Prot: SPIC_HUMAN, Q8N5J4
Function: Controls the development of red pulp macrophages required for red blood cells recycling and iron
homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can
act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPIC gene promoter:
         STAT5B   Elk-1   MEF-2   CREB   MEF-2A   POU2F1   deltaCREB   POU2F1a   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPIC promoter sequence
   Search Chromatin IP Primers for SPIC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPIC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.2   Ensembl cytogenetic band:  12q23.2   HGNC cytogenetic band: 12q23

SPIC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPIC gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P101870:  view genomic region     (about GC identifiers)

Start:
101,869,199 bp from pter      End:
101,880,775 bp from pter
Size:
11,577 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SPIC_HUMAN, Q8N5J4 (See protein sequence)
Recommended Name: Transcription factor Spi-C  
Size: 248 amino acids; 29180 Da
Subunit: Binds DNA as a monomer

Explore the universe of human proteins at neXtProt for SPIC: NX_Q8N5J4

Explore proteomics data for SPIC at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SPIC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689536.1  
    ENSEMBL proteins: 
     ENSP00000448580   ENSP00000299272  

    SPIC Human Recombinant Protein Products:

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    Novus Biologicals SPIC Protein
    Novus Biologicals SPIC Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SPIC

     
    Search eBioscience for Proteins for SPIC 

     
    antibodies-online proteins for SPIC (2 products) 

     
    antibodies-online peptides for SPIC

    SPIC Antibody Products:

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    ThermoFisher Antibodies for SPIC
    antibodies-online antibodies for SPIC (22 products) 

    SPIC Assay Products:

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    Cloud-Clone Corp. ELISAs for SPIC
    Cloud-Clone Corp. CLIAs for SPIC
    Search eBioscience for ELISAs for SPIC 
    antibodies-online kits for SPIC (17 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR000418 Ets_dom

    Graphical View of Domain Structure for InterPro Entry Q8N5J4

    ProtoNet protein and cluster: Q8N5J4

    UniProtKB/Swiss-Prot: SPIC_HUMAN, Q8N5J4
    Similarity: Belongs to the ETS family
    Similarity: Contains 1 ETS DNA-binding domain


    Find genes that share domains with SPIC           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPIC_HUMAN, Q8N5J4
    Function: Controls the development of red pulp macrophages required for red blood cells recycling and iron
    homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can
    act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IBA--
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with SPIC           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SPIC:
     Increased S DNA content, incre 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Spic):
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 

    Find genes that share phenotypes with SPIC           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Spictm1.1Kmm for SPIC

       genOway: Develop your customized and physiologically relevant rodent model for SPIC

    miRNA
    Products:
        
    miRTarBase miRNAs that target SPIC:
    hsa-mir-335-5p (MIRT018368)

    Block miRNA regulation of human, mouse, rat SPIC using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SPIC
    SwitchGear 3'UTR luciferase reporter plasmidSPIC 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SPIC
    Predesigned siRNA for gene silencing in human, mouse, rat SPIC

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SPIC

    Clone
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    OriGene ORF clones in mouse, rat for SPIC
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    GenScript: all cDNA clones in your preferred vector: SPIC (NM_152323)
    Sino Biological Human cDNA Clone for SPIC
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPIC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPIC

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPIC


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPIC_HUMAN, Q8N5J4: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IBA--

    Find genes that share ontologies with SPIC           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPIC
    Interactions:

        Search GeneGlobe Interaction Network for SPIC

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001824blastocyst development IEA--
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter IBA--
    GO:0006366transcription from RNA polymerase II promoter IBA--

    Find genes that share ontologies with SPIC           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPIC



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SPIC gene: 
    NM_152323.1  

    Unigene Cluster for SPIC:

    Spi-C transcription factor (Spi-1/PU.1 related)
    Hs.577097  [show with all ESTs]
    Unigene Representative Sequence: AF518404
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000551346(uc001tid.3 uc010svp.2 uc009zua.3 uc021rcq.1)
    ENST00000299272
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SPIC using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidSPIC 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SPIC
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    GenScript: all cDNA clones in your preferred vector: SPIC (NM_152323)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPIC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPIC
    Primer
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    OriGene qPCR primer pairs and template standards for SPIC
    OriGene qSTAR qPCR primer pairs in human, mouse for SPIC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPIC
      QuantiTect SYBR Green Assays in human, mouse, rat SPIC
      QuantiFast Probe-based Assays in human, mouse, rat SPIC

    Additional mRNA sequence: 

    AF518404.1 BC032317.1 

    1 DOTS entry:

    DT.100015091 

    7 AceView cDNA sequences:

    NM_152323 BC032317 BI770622 AF518404 BG567207 BI838200 R10669 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SPIC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTGCTAAAT
    SPIC Expression
    About this image


    SPIC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Inner Cell Mass Cells Inner Cell Mass
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
     
     Heart (Cardiovascular System)
             Mature Cardiac Fibroblasts Myocardium
     
     Fibroblasts
             Mature Cardiac Fibroblasts Myocardium
     
     Liver (Hepatobiliary System)
             Liver Lobule
    SPIC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPIC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.577097

    UniProtKB/Swiss-Prot: SPIC_HUMAN, Q8N5J4
    Tissue specificity: Preferentially detected in fetal and adult spleen, lymph nodes and at lower levels in bone
    marrow and fetal liver

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPIC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SPIC gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spic1 , 5 Spi-C transcription factor (Spi-1/PU.1 related)1, 5 77.73(n)1
    68.07(a)1
      10 (44.14 cM)5
    207281  NM_011461.31  NP_035591.31 
     886747725 
    chicken
    (Gallus gallus)
    Aves SPIC1 Spi-C transcription factor (Spi-1/PU.1 related) 70.57(n)
    67.36(a)
      427915  XM_425488.3  XP_425488.3 
    lizard
    (Anolis carolinensis)
    Reptilia SPIC6
    Spi-C transcription factor (Spi-1/PU.1 related)
    58(a)
    1 ↔ 1
    5(17189308-17198320)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia spic1 Spi-C transcription factor (Spi-1/PU.1 related) 64.89(n)
    64(a)
      100488046  XM_002936839.1  XP_002936885.1 
    zebrafish
    (Danio rerio)
    Actinopterygii spic1 Spi-C transcription factor (Spi-1/PU.1 related) 53.06(n)
    50.51(a)
      447882  NM_001004621.2  NP_001004621.1 


    ENSEMBL Gene Tree for SPIC (if available)
    TreeFam Gene Tree for SPIC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SPIC gene
    ENSG000001425392  SPIB2  SPI12  
    3 SIMAP similar genes for SPIC using alignment to 1 protein entry:     SPIC_HUMAN:
    SPI1    ELF5    SPIB

    Find genes that share paralogs with SPIC           About GenesLikeMe


    5 Pseudogenes.org Pseudogenes for SPIC
    PGOHUM00000242206 PGOHUM00000236914 PGOHUM00000237363 PGOHUM00000245808 PGOHUM00000235494


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SPIC (see all 316)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs793215671,2
    C,F--101868727(+) AGACCG/AATTTG 1 -- us2k12Minor allele frequency- A:0.05WA EA 238
    rs1823422171,2
    --101868795(+) GAATTC/GGGAGA 1 -- us2k10--------
    rs73094471,2
    C,F,A,H--101868843(+) GTTGCA/CTGGGT 1 -- us2k119Minor allele frequency- C:0.38NA NS EA WA CSA 906
    rs352640291,2
    C,F--101868895(+) CCTAAG/ATTGGG 1 -- us2k19Minor allele frequency- A:0.34NA WA CSA 252
    rs1149226261,2
    C,F--101868899(+) AGTTGG/AGCGGG 1 -- us2k11Minor allele frequency- A:0.09WA 118
    rs1866952461,2
    --101869075(+) TCCTTA/CAAAAC 1 -- us2k10--------
    rs73101631,2
    C,F,H--101869220(+) CTACCG/ATTGAA 1 -- us2k1 ese34Minor allele frequency- A:0.01NS EA 420
    rs1157252261,2
    F--101869279(+) CTTCCC/TGGTAA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1392757041,2
    C--101869324(+) TCACTA/GTTCAT 1 -- us2k10--------
    rs1899302791,2
    --101869452(+) CTTGTA/CATAGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SPIC (101869199 - 101880775 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SPIC:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv507669CNV Insertion20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SPIC
    DNA2.0 Custom Variant and Variant Library Synthesis for SPIC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612568    OMIM disorders: --

    2 diseases for SPIC:    
    About MalaCards
    wolman disease    lipomatosis

    3 diseases from the University of Copenhagen DISEASES database for SPIC:
    Wolman disease     Dilated cardiomyopathy     Lipomatosis

    Find genes that share disorders with SPIC           About GenesLikeMe


    Export disorders for SPIC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SPIC gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SPIC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic structure of mouse SPI-C and genomic structure and expression pattern of human SPI-C. (PubMed id 12459275)1, 2, 3 Carlsson R.... Leanderson T. (Gene 2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    4. SPI-C and STAT6 can cooperate to stimulate IgE germline transcription. (PubMed id 16647686)1 Carlsson R....Leanderson T. (Biochem. Biophys. Res. Commun. 2006)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 121599 HGNC: 29549 AceView: SPIC Ensembl:ENSG00000166211 euGenes: HUgn121599
    ECgene: SPIC H-InvDB: SPIC

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SPIC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SPIC gene:
    Search GeneIP for patents involving SPIC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SPIC   OriGene RNAi products in human, mouse, rat for SPIC  
     OriGene qPCR primer pairs and template standards for SPIC   OriGene Protein Over-expression Lysate for SPIC  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SPIC  
     OriGene qSTAR qPCR primer pairs in human, mouse for SPIC   OriGene Purified Protein for SPIC  
     OriGene ORF clones in mouse, rat for SPIC   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SPIC   OriGene Custom Protein Services for SPIC  

     
     
     Block miRNA regulation of human, mouse, rat SPIC using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SPIC
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPIC Predesigned siRNA for gene silencing in human, mouse, rat SPIC
     QuantiFast Probe-based Assays in human, mouse, rat SPIC QuantiTect SYBR Green Assays in human, mouse, rat SPIC
     Custom PCR Arrays for SPIC Search Chromatin IP Primers for SPIC
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPIC  Search GeneGlobe Interaction Network for SPIC
     Regulatory tfbs in SPIC promoter
     GenScript Custom Purified and Recombinant Proteins Services for SPIC GenScript cDNA clones with any tag delivered in your preferred vector for SPIC
     GenScript Custom Assay Services for SPIC GenScript Custom overexpressing Cell Line Services for SPIC
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
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     Search Tocris compounds for SPIC
     Browse Sino Biological Proteins
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     cDNA Clones for SPIC
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SPIC antibodies
     SPIC proteins
     SPIC lysates
     Antibodies for SPIC
     See all of Abcam's Antibodies, Kits and Proteins for SPIC
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     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SPIC
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     ELISAs for SPIC
     CLIAs for SPIC



     Browse ESI BIO Cell Lines and PureStem Progenitors for SPIC
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPIC
     SwitchGear 3'UTR luciferase reporter plasmids for SPIC
     SwitchGear Promoter luciferase reporter plasmids for SPIC
     ThermoFisher Antibodies for SPIC
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPIC
     Browse compounds at ApexBio
     Search Addgene for plasmids for SPIC
      Search eBioscience for proteins for SPIC
      Search eBioscience for elisas for SPIC
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for SPIC
     antibodies-online antibodies for SPIC (22 products)
     antibodies-online kits for SPIC (17 products)
     antibodies-online peptides for SPIC
     antibodies-online proteins for SPIC (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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