Aliases for SPIC Gene
Aliases for SPIC Gene
External Ids for SPIC Gene
- HGNC: 29549
- Entrez Gene: 121599
- Ensembl: ENSG00000166211
- OMIM: 612568
- UniProtKB: Q8N5J4
Previous GeneCards Identifiers for SPIC Gene
- GC12P101853
- GC12P100371
- GC12P100393
- GC12P101870
- GC12P098930
Summaries for SPIC Gene
-
The protein encoded by this gene regulates the development of red pulp macrophages, which are necessary for iron homeostasis and the recycling of red blood cells. [provided by RefSeq, Aug 2016]
GeneCards Summary for SPIC Gene
SPIC (Spi-C Transcription Factor) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is SPIB.
UniProtKB/Swiss-Prot for SPIC Gene
-
Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5-GAGGA[AT]-3) that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity).
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPIC Gene
Genomics for SPIC Gene
GeneHancer (GH) Regulatory Elements for SPIC Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH12I101475 | Promoter | 0.5 | EPDnew | 550.8 | 0.0 | -6 | 0.1 | SPIC RNA5SP367 | ||
GH12I101582 | Enhancer | 0.4 | ENCODE dbSUPER | 10.5 | +108.5 | 108525 | 2.7 | CHPT1 SPIC RNA5SP367 RNU5E-5P SYCP3 RNU6-101P MYBPC1 LOC105369938 |
Regulatory Element Products
Genomic Locations for SPIC Gene
- chr12:101,475,323-101,487,566
- (GRCh38/hg38)
- Size:
- 12,244 bases
- Orientation:
- Plus strand
- chr12:101,869,199-101,880,775
- (GRCh37/hg19)
Genomic View for SPIC Gene
- Cytogenetic band:
-
- 12q23.2 by Ensembl
- 12q23.2 by Entrez Gene
- 12q23.2 by HGNC


RefSeq DNA sequence for SPIC Gene
Proteins for SPIC Gene
-
Protein details for SPIC Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N5J4-SPIC_HUMAN
- Recommended name:
- Transcription factor Spi-C
- Protein Accession:
- Q8N5J4
Protein attributes for SPIC Gene
- Size:
- 248 amino acids
- Molecular mass:
- 29180 Da
- Quaternary structure:
-
- Binds DNA as a monomer.
Protein Expression for SPIC Gene
Post-translational modifications for SPIC Gene
Other Protein References for SPIC Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for SPIC
-
Abcam antibodies for SPIC
- Invitrogen Antibodies for SPIC
- GeneTex SPIC antibody for SPIC
-
Santa Cruz Biotechnology (SCBT) Antibodies for SPIC
Protein Products
-
OriGene Purified Proteins for SPIC
- Search Origene for MassSpec and Protein Over-expression Lysates for SPIC
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- antibodies-online: Search results for 6 available SPIC Proteins ranked by validation data
- Compare Top SPIC Proteins
-
Quality Products:
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-
Abcam proteins for SPIC
Assay Products
- antibodies-online: Search results for 1 available SPIC Elisa Kits ranked by validation data
- Compare Top SPIC Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for SPIC Gene
Domains & Families for SPIC Gene
Gene Families for SPIC Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for SPIC Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SPIC Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8N5J4- Family:
-
- Belongs to the ETS family.
Function for SPIC Gene
Molecular function for SPIC Gene
- UniProtKB/Swiss-Prot Function:
- Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5-GAGGA[AT]-3) that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity).
Phenotypes From GWAS Catalog for SPIC Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | IBA | -- |
GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
GO:0003677 | DNA binding | IEA | -- |
GO:0003700 | DNA binding transcription factor activity | IEA | -- |
Phenotypes for SPIC Gene
- MGI mutant phenotypes for SPIC:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for SPIC:
Animal Models for SPIC Gene
- MGI Knock Outs for SPIC:
-
- Spic tm1.1Kmm
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for SPIC gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SPIC gene
- Search ViGene Biosciences for SPIC
CRISPR Products
-
OriGene CRISPR knockouts for SPIC
- genomics-online: gRNA clones - Search results for available SPIC gene related products
- Applied Biological Materials CRISPR for SPIC
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPIC
- GenScript: Design CRISPR guide RNA sequences for SPIC
miRNA for SPIC Gene
- miRTarBase miRNAs that target SPIC
-
- hsa-mir-335-5p (MIRT018368)
- hsa-mir-6885-3p (MIRT525468)
- hsa-mir-1238-3p (MIRT525469)
- hsa-mir-670-3p (MIRT525470)
- hsa-mir-6881-3p (MIRT525471)
- hsa-mir-6780a-3p (MIRT525472)
- hsa-mir-7111-3p (MIRT525473)
- hsa-mir-4775 (MIRT525474)
- hsa-mir-877-3p (MIRT525475)
- hsa-mir-5590-3p (MIRT525476)
- hsa-mir-142-5p (MIRT525477)
- hsa-mir-561-3p (MIRT525478)
- hsa-mir-548at-5p (MIRT525479)
- hsa-mir-4668-5p (MIRT617249)
- hsa-mir-3613-3p (MIRT617250)
- hsa-mir-382-5p (MIRT617251)
- hsa-mir-495-5p (MIRT617252)
- hsa-mir-590-3p (MIRT640289)
- hsa-mir-498 (MIRT678010)
- hsa-mir-6778-3p (MIRT678011)
- hsa-mir-4279 (MIRT678012)
- hsa-mir-5186 (MIRT678013)
- hsa-mir-1976 (MIRT678014)
- hsa-mir-3653-5p (MIRT678015)
- hsa-mir-150-5p (MIRT678016)
- hsa-mir-6747-3p (MIRT678017)
- hsa-mir-6727-3p (MIRT678018)
- hsa-mir-4722-3p (MIRT678019)
- hsa-mir-6814-5p (MIRT678020)
- hsa-mir-5697 (MIRT678021)
- hsa-mir-562 (MIRT678022)
miRNA Products
- Search ViGene Biosciences for SPIC
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SPIC
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- genomics-online: shRNA clones - Search results for available SPIC gene related products
-
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Clone Products
- Sino Biological Human cDNA Clone for SPIC
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- genomics-online: cdna clones - Search results for available SPIC gene related products
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- Applied Biological Materials Clones for SPIC
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for SPIC
-
ViGene Biosciences adenoviral particle packaged cDNA for SPIC gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SPIC gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SPIC gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPIC Gene
Localization for SPIC Gene
Subcellular locations from UniProtKB/Swiss-Prot for SPIC Gene
- Nucleus.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for SPIC Gene
Pathways & Interactions for SPIC Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001824 | blastocyst development | IEA | -- |
GO:0006351 | transcription, DNA-templated | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | IBA | -- |
GO:0006366 | transcription by RNA polymerase II | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for SPIC Gene
Transcripts for SPIC Gene
mRNA/cDNA for SPIC Gene
- (3) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (7) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SPIC Gene
CRISPR Products
-
OriGene CRISPR knockouts for SPIC
- genomics-online: gRNA clones - Search results for available SPIC gene related products
- Applied Biological Materials CRISPR for SPIC
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPIC
- GenScript: Design CRISPR guide RNA sequences for SPIC
miRNA Products
- Search ViGene Biosciences for SPIC
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SPIC
- Browse OriGene Inhibitory RNA Products For SPIC
- genomics-online: shRNA clones - Search results for available SPIC gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SPIC gene
Clone Products
- Sino Biological Human cDNA Clone for SPIC
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- genomics-online: cdna clones - Search results for available SPIC gene related products
- orf clones - Search results for available SPIC gene related products
- Applied Biological Materials Clones for SPIC
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for SPIC Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
-
Heart (Cardiovascular System)
- Mature Cardiac Fibroblasts Myocardium
-
Fibroblasts
- Mature Cardiac Fibroblasts Myocardium
- Liver (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for SPIC Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPIC Gene
NURSA nuclear receptor signaling pathways regulating expression of SPIC Gene:
SPICSOURCE GeneReport for Unigene cluster for SPIC Gene:
Hs.577097mRNA Expression by UniProt/SwissProt for SPIC Gene:
Q8N5J4-SPIC_HUMANEvidence on tissue expression from TISSUES for SPIC Gene
- Pancreas(4)
- Spleen(2.5)
Primer Products
-
OriGene qPCR primer pairs for SPIC
-
OriGene qPCR primer pairs and template standards for SPIC
- genomics-online: primer clones - Search results for available SPIC gene related products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SPIC Gene
Orthologs for SPIC Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | SPIC 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | SPIC 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | SPIC 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Spic 33 |
|
||
mouse (Mus musculus) |
Mammalia | Spic 33 16 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | SPIC 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | SPIC 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | SPIC 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | SPIC 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | spic 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | spic 33 34 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for SPIC was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for SPIC Gene
(3) SIMAP similar genes for SPIC Gene using alignment to 1 proteins:
Pseudogenes.org Pseudogenes for SPIC Gene
Variants for SPIC Gene
SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000266836 | -- | 101,478,343(+) | TTTAATTTAATTT/TTTAATTT | intron_variant | |
rs1000468963 | -- | 101,485,299(+) | G/T | intron_variant | |
rs1000496178 | -- | 101,480,449(+) | T/C | intron_variant | |
rs1000597179 | -- | 101,486,258(+) | T/A/C | intron_variant | |
rs1000632210 | -- | 101,480,182(+) | C/T | intron_variant |
Additional Variant Information for SPIC Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SPIC
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPIC Gene
Disorders for SPIC Gene
Additional Disease Information for SPIC
No disorders were found for SPIC Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPIC Gene
Publications for SPIC Gene
- Genomic structure of mouse SPI-C and genomic structure and expression pattern of human SPI-C. (PMID: 12459275) Carlsson R … Leanderson T (Gene 2002) 2 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases. (PMID: 24709693) Cobb J … Thomson W (The pharmacogenomics journal 2014) 3 58
- Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 58
- SPI-C and STAT6 can cooperate to stimulate IgE germline transcription. (PMID: 16647686) Carlsson R … Leanderson T (Biochemical and biophysical research communications 2006) 3 58
Products for SPIC Gene
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- Novus Biologicals proteins and lysates for SPIC
- Novus Biologicals
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- Abcam antibodies for SPIC
- Abcam proteins for SPIC
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- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for SPIC
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- antibodies-online: Search results for 22 available SPIC Antibodies ranked by validation data
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- antibodies-online: Search results for 1 available SPIC Elisa Kits ranked by validation data
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- Quality Products:
- antibodies-online: Search results for 6 available SPIC Proteins ranked by validation data
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- GeneTex SPIC antibody for SPIC
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- Horizon Cell Lines for SPIC
- genomics-online: cdna clones - Search results for available SPIC gene related products
- orf clones - Search results for available SPIC gene related products
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Sources for SPIC Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew