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SPIC Gene

protein-coding GIFtS: 47
GCID: GC12P101870

Spi-C Transcription Factor (Spi-1/PU.1 Related)

See SPIC-related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Spi-C Transcription Factor (Spi-1/PU.1 Related)¹ ²
SPI-C²
Transcription Factor Spi-C²

External Ids:	HGNC: 29549¹	Entrez Gene: 121599²	Ensembl: ENSG00000166211⁷	OMIM: 612568⁵	UniProtKB: Q8N5J4³

Export aliases for SPIC gene to outside databases

Previous GC identifers: GC12P101853 GC12P100371 GC12P100393 GC12P098930

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SPIC Gene:

SPIC (Spi-C transcription factor (Spi-1/PU.1 related)) is a protein-coding gene. Diseases associated with SPIC include wolman disease, and lipomatosis. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ENSG00000142539.

UniProtKB/Swiss-Prot: SPIC_HUMAN, Q8N5J4

Function: Controls the development of red pulp macrophages required for red blood cells recycling and iron

homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can

act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000012.11 NT_029419.13 NC_018923.2

Regulatory elements:

Regulatory transcription factor binding sites in the SPIC gene promoter:
STAT5B Elk-1 MEF-2 CREB MEF-2A POU2F1 deltaCREB POU2F1a aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SPIC promoter sequence

Search Chromatin IP Primers for SPIC

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPIC

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.2 Ensembl cytogenetic band: 12q23.2 HGNC cytogenetic band: 12q23

SPIC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPIC gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P101870: view genomic region (about GC identifiers)

Start:	101,869,199 bp from pter	End:	101,880,775 bp from pter
Size:	11,577 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: SPIC_HUMAN, Q8N5J4 (See protein sequence)

Recommended Name: Transcription factor Spi-C

Size: 248 amino acids; 29180 Da

Subunit: Binds DNA as a monomer

Explore the universe of human proteins at neXtProt for SPIC: NX_Q8N5J4

Explore proteomics data for SPIC at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See SPIC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_689536.1

ENSEMBL proteins:

ENSP00000448580 ENSP00000299272

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

2 InterPro protein domains:

IPR011991 WHTH_DNA-bd_dom

IPR000418 Ets_dom

Graphical View of Domain Structure for InterPro Entry Q8N5J4

ProtoNet protein and cluster: Q8N5J4

UniProtKB/Swiss-Prot: SPIC_HUMAN, Q8N5J4

Similarity: Belongs to the ETS family

Similarity: Contains 1 ETS DNA-binding domain

Find genes that share domains with SPIC About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SPIC_HUMAN, Q8N5J4

Function: Controls the development of red pulp macrophages required for red blood cells recycling and iron

homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can

act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity)

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	IBA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	--	--
GO:0043565	sequence-specific DNA binding	IEA	--

Find genes that share ontologies with SPIC About GenesLikeMe

Phenotypes:
1 GenomeRNAi human phenotype for SPIC:

Increased S DNA content, incre

4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Spic):

hematopoietic system

homeostasis/metabolism

immune system

mortality/aging

Find genes that share phenotypes with SPIC About GenesLikeMe

Animal Models:
MGI mouse knock-out Spic^tm1.1Kmm for SPIC

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

SPIC_HUMAN, Q8N5J4: Nucleus (Probable)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	4
cytosol	2
golgi apparatus	1
plasma membrane	1

About this image

Gene Ontology (GO): 1 cellular component term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IBA	--

Find genes that share ontologies with SPIC About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for SPIC
Interactions:

Search GeneGlobe Interaction Network for SPIC

Gene Ontology (GO): Selected biological process terms (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001824	blastocyst development	IEA	--
GO:0006351	transcription, DNA-templated	--	--
GO:0006355	regulation of transcription, DNA-templated	--	--
GO:0006357	regulation of transcription from RNA polymerase II promoter	IBA	--
GO:0006366	transcription from RNA polymerase II promoter	IBA	--

Find genes that share ontologies with SPIC About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for SPIC gene (5 alternative transcripts):

NM_152323.1 XM_005268646.1 XM_005268647.1 XM_006719238.1 XM_006719239.1

Unigene Cluster for SPIC:

Spi-C transcription factor (Spi-1/PU.1 related)

Hs.577097 [show with all ESTs]

Unigene Representative Sequence: AF518404

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000551346(uc001tid.3 uc010svp.2 uc009zua.3 uc021rcq.1)

ENST00000299272

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Additional mRNA sequence:

AF518404.1 BC032317.1

1 DOTS entry:

DT.100015091

7 AceView cDNA sequences:

NM_152323 BC032317 BI770622 AF518404 BG567207 BI838200 R10669

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SPIC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ATTGCTAAAT

About this image

SPIC expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 4) fully expand


Inner Cell Mass (Early Embryonic Tissues) fully expand to see all 2 entries
Inner Cell Mass Cells Inner Cell Mass
Blimp1- mVenus and stella-ECFP genetically modified stem cells

Heart (Cardiovascular System)
Mature Cardiac Fibroblasts Myocardium

Fibroblasts
Mature Cardiac Fibroblasts Myocardium

Liver (Hepatobiliary System)
Liver Lobule

SPIC Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

SPIC Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.577097

UniProtKB/Swiss-Prot: SPIC_HUMAN, Q8N5J4

Tissue specificity: Preferentially detected in fetal and adult spleen, lymph nodes and at lower levels in bone

marrow and fetal liver

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for SPIC gene from Selected species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Spic^{1 , 5}	Spi-C transcription factor (Spi-1/PU.1 related)^{1, 5}	77.73(n)¹ 68.07(a)¹		10 (44.14 cM)⁵ 20728¹ NM_011461.3¹ NP_035591.3¹ 88674772⁵
chicken (Gallus gallus)	Aves	SPIC¹	Spi-C transcription factor (Spi-1/PU.1 related)	70.57(n) 67.36(a)		427915 XM_425488.3 XP_425488.3
lizard (Anolis carolinensis)	Reptilia	SPIC⁶	Spi-C transcription factor (Spi-1/PU.1 related)	58(a)	1 ↔ 1	5(17189308-17198320)
tropical clawed frog (Xenopus tropicalis)	Amphibia	spic¹	Spi-C transcription factor (Spi-1/PU.1 related)	64.89(n) 64(a)		100488046 XM_002936839.1 XP_002936885.1
zebrafish (Danio rerio)	Actinopterygii	spic¹	Spi-C transcription factor (Spi-1/PU.1 related)	53.06(n) 50.51(a)		447882 NM_001004621.2 NP_001004621.1

ENSEMBL Gene Tree for SPIC (if available)
TreeFam Gene Tree for SPIC (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for SPIC gene

ENSG00000142539² SPIB² SPI1²

3 SIMAP similar genes for SPIC using alignment to 1 protein entry: SPIC_HUMAN:

SPI1 ELF5 SPIB

Find genes that share paralogs with SPIC About GenesLikeMe

5 Pseudogenes.org Pseudogenes for SPIC
PGOHUM00000242206 PGOHUM00000236914 PGOHUM00000237363 PGOHUM00000245808 PGOHUM00000235494

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs79321567^1,2	C,F	--	101868727(+)	`AGACCG/AATTTG`	1	--	us2k¹		2		WA EA	238
rs182342217^1,2		--	101868795(+)	`GAATTC/GGGAGA`	1	--	us2k¹		0	--	--	--	--
rs7309447^1,2	C,F,A,H	--	101868843(+)	`GTTGCA/CTGGGT`	1	--	us2k¹		19		NA NS EA WA CSA	906
rs35264029^1,2	C,F	--	101868895(+)	`CCTAAG/ATTGGG`	1	--	us2k¹		9		NA WA CSA	252
rs114922626^1,2	C,F	--	101868899(+)	`AGTTGG/AGCGGG`	1	--	us2k¹		1		WA	118
rs186695246^1,2		--	101869075(+)	`TCCTTA/CAAAAC`	1	--	us2k¹		0	--	--	--	--
rs7310163^1,2	C,F,H	--	101869220(+)	`CTACCG/ATTGAA`	1	--	us2k¹ ese³		4		NS EA	420
rs115725226^1,2	F	--	101869279(+)	`CTTCCC/TGGTAA`	1	--	us2k¹		1		WA	118
rs139275704^1,2	C	--	101869324(+)	`TCACTA/GTTCAT`	1	--	us2k¹		0	--	--	--	--
rs189930279^1,2		--	101869452(+)	`CTTGTA/CATAGC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SPIC (101869199 - 101880775 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for SPIC: About this table

Variant ID	Type	Subtype	PubMed ID
nsv507669	CNV	Insertion	20534489

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing SPIC

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

OMIM gene information: 612568 OMIM disorders: --

2 diseases for SPIC:
About MalaCards

wolman disease lipomatosis

3 inferred disease relationships from the University of Copenhagen DISEASES database for SPIC:

Wolman disease Dilated cardiomyopathy Lipomatosis

Find genes that share disorders with SPIC About GenesLikeMe

Export disorders for SPIC gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SPIC gene integrated from 10 sources:
(articles sorted by number of sources associating them with SPIC)

Utopia: connect your pdf to the dynamic
world of online information

Genomic structure of mouse SPI-C and genomic structure and expression pattern of human SPI-C. (PubMed id 12459275)^{1, 2, 3} Carlsson R.... Leanderson T. (Gene 2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
SPI-C and STAT6 can cooperate to stimulate IgE germline transcription. (PubMed id 16647686)¹ Carlsson R....Leanderson T. (Biochem. Biophys. Res. Commun. 2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 121599	HGNC: 29549	AceView: SPIC	Ensembl:ENSG00000166211	euGenes: HUgn121599
ECgene: SPIC	H-InvDB: SPIC

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SPIC	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SPIC gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SPIC gene:
Search GeneIP for patents involving SPIC

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section


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	OriGene Antibodies for SPIC		OriGene RNAi products in human, mouse, rat for SPIC
	OriGene qPCR primer pairs and template standards for SPIC		OriGene Protein Over-expression Lysate for SPIC
	OriGene Custom Mass Spec		OriGene clones in human, mouse for SPIC
	OriGene qSTAR qPCR primer pairs in human, mouse for SPIC		OriGene Purified Protein for SPIC
	OriGene ORF clones in mouse, rat for SPIC		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SPIC		OriGene Custom Protein Services for SPIC

	Block miRNA regulation of human, mouse, rat SPIC using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing SPIC
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPIC		Predesigned siRNA for gene silencing in human, mouse, rat SPIC
	QuantiFast Probe-based Assays in human, mouse, rat SPIC		QuantiTect SYBR Green Assays in human, mouse, rat SPIC
	Custom PCR Arrays for SPIC		Search Chromatin IP Primers for SPIC
	Pre-validated RT² qPCR Primer Assay in human, mouse, rat SPIC		Search GeneGlobe Interaction Network for SPIC
	Regulatory tfbs in SPIC promoter

	GenScript Custom Purified and Recombinant Proteins Services for SPIC		GenScript cDNA clones with any tag delivered in your preferred vector for SPIC
	GenScript Custom Assay Services for SPIC		GenScript Custom overexpressing Cell Line Services for SPIC
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPIC

	SwitchGear 3'UTR luciferase reporter plasmids for SPIC
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ThermoFisher Antibodies for SPIC

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPIC

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genOway: Develop your customized and physiologically relevant rodent model for SPIC

	antibodies-online antibodies for SPIC (22 products)
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Search GeneTex for proteins for SPIC

GeneCards Home - Full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 2 Nov 2014 , 8 Jan 2015 , 3 Feb 2015

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The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SPIC gene at Home site.

Version: 3.12.348 25 Feb 2015
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SPIC Gene

Spi-C Transcription Factor (Spi-1/PU.1 Related)

Aliases
for SPIC gene

Summaries
for SPIC gene

Genomic Views
for SPIC gene

Proteins
for SPIC gene

SPIC Human Recombinant Protein Products:

SPIC Antibody Products:

SPIC Assay Products:

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Families
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for SPIC gene

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Pathways & Interactions
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Drugs & Compounds
for SPIC gene

Transcripts
for SPIC gene

Expression
for SPIC gene

Orthologs
for SPIC gene

Paralogs
for SPIC gene

Genomic Variants
for SPIC gene

Disorders / Diseases
for SPIC gene

Publications
for SPIC gene

External Searches for SPIC gene

Genome Databases showing SPIC gene

Other Databases showing SPIC gene

Specialized Databases showing SPIC gene

Intellectual Property
for SPIC gene

Products
for SPIC gene

View Random Gene

GeneCards Suite

Advanced Search

Export list of displayed genes

SPIC Gene

Spi-C Transcription Factor (Spi-1/PU.1 Related)

Aliasesfor SPIC gene

Summariesfor SPIC gene

Genomic Viewsfor SPIC gene

Proteinsfor SPIC gene

SPIC Human Recombinant Protein Products:

SPIC Antibody Products:

SPIC Assay Products:

Domains /Familiesfor SPIC gene

Functionfor SPIC gene

Localizationfor SPIC gene

Pathways & Interactionsfor SPIC gene

Drugs & Compoundsfor SPIC gene

Transcriptsfor SPIC gene

Expression for SPIC gene

Orthologsfor SPIC gene

Paralogsfor SPIC gene

Genomic Variantsfor SPIC gene

Disorders / Diseasesfor SPIC gene

Publicationsfor SPIC gene

External Searches for SPIC gene

Genome Databases showing SPIC gene

Other Databases showing SPIC gene

Specialized Databases showing SPIC gene

Intellectual Propertyfor SPIC gene

Productsfor SPIC gene

View Random Gene

Aliases
for SPIC gene

Summaries
for SPIC gene

Genomic Views
for SPIC gene

Proteins
for SPIC gene

Domains /
Families
for SPIC gene

Function
for SPIC gene

Localization
for SPIC gene

Pathways & Interactions
for SPIC gene

Drugs & Compounds
for SPIC gene

Transcripts
for SPIC gene

Expression
for SPIC gene

Orthologs
for SPIC gene

Paralogs
for SPIC gene

Genomic Variants
for SPIC gene

Disorders / Diseases
for SPIC gene

Publications
for SPIC gene

Intellectual Property
for SPIC gene

Products
for SPIC gene