SPIC Gene
protein-coding GIFtS : 45
GCID: GC12 P101870
Spi-C transcription factor (Spi-1/PU.1 related)
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Aliasesfor SPIC gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Spi-C Transcription Factor (Spi-1/PU.1 Related) 1 2 SPI-C1 2 MGC406111 Transcription Factor Spi-C2
Export aliases for SPIC gene to outside databases Previous GC identifers: GC12P101853 GC12P100371 GC12P100393 GC12P098930
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Summariesfor SPIC gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: SPIC_HUMAN, Q8N5J4 Function : Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis.Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity)
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Genomic Viewsfor SPIC gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000012.11 NC_018923.1 NT_029419.12 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SPIC gene promoter: STAT5B Elk-1 MEF-2 CREB MEF-2A POU2F1 deltaCREB POU2F1a aMEF-2 Other transcription factors Search SABiosciences Chromatin IP Primers for SPIC Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPIC
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 12q23.2 Ensembl cytogenetic band: 12q23.2 HGNC cytogenetic band: 12q23 SPIC Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12P101870: view genomic region
(about GC identifiers )
Start:
101,869,199 bp from pter
End:
101,880,775 bp from pter
Size:
11,577 bases
Orientation:
plus strand
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Proteinsfor SPIC gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: SPIC_HUMAN, Q8N5J4 (See
protein sequence )Recommended Name: Transcription factor Spi-C Size : 248 amino acids; 29180 Da
Subunit : Binds DNA as a monomer
Subcellular location : Nucleus (Probable)Explore the universe of human proteins at neXtProt for SPIC: NX_Q8N5J4 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8N5J4 SPIC Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_689536.1 ENSEMBL proteins: ENSP00000448580 ENSP00000299272 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
IEA --
SPIC for ontologies About GeneDecksing SPIC Antibody Products: Assay Products for SPIC:
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Protein
Domains / Familiesfor SPIC gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
SPIC for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q8N5J4 ProtoNet protein and cluster: Q8N5J4
UniProtKB/Swiss-Prot: SPIC_HUMAN, Q8N5J4 Similarity : Belongs to the ETS familySimilarity : Contains 1 ETS DNA-binding domain
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Functionfor SPIC gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: SPIC_HUMAN, Q8N5J4 Function : Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis.Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SPIC (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SPICOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SPIC (NM_152323 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPIC Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SPIC
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPIC
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003700 sequence-specific DNA binding transcription factor activity
IEA -- GO:0043565 sequence-specific DNA binding
IEA --
SPIC for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for SPIC :Animal Models: Mouse knock-out Spic tm1.1Kmm for SPIC 4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Spic) :
SPIC for phenotypes About GeneDecksing
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Pathways & Interactionsfor SPIC gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPIC Gene Ontology (GO): 3 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0001824 blastocyst development
IEA -- GO:0006351 transcription, DNA-dependent
IEA -- GO:0045944 positive regulation of transcription from RNA polymerase II promoter
IEA --
SPIC for ontologies About GeneDecksing
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Drugs & Compoundsfor SPIC gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for SPIC Search CenterWatch for drugs/clinical trials and news about SPIC
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Transcriptsfor SPIC gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for SPIC gene: NM_152323.1 Unigene Cluster for SPIC:
Spi-C transcription factor (Spi-1/PU.1 related) Hs.577097 [show with all ESTs ] Unigene Representative Sequence: AF518404 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000551346 (uc001tid.3 uc010svp.2 uc009zua.3 uc021rcq.1 )ENST00000299272 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SPIC (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SPICOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SPIC (NM_152323 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPIC Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SPIC
Additional cDNA sequence: AF518404.1 BC032317.1
1 DOTS entry : DT.100015091
7 AceView cDNA sequences :
BC032317 NM_152323 BG567207 BI770622 BI838200 AF518404 R10669 GeneLoc Exon Structure
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Expression for SPIC gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section SPIC expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: ATTGCTAAAT
About this image SPIC expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See SPIC Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SPIC SOURCE GeneReport for Unigene cluster: Hs.577097 UniProtKB/Swiss-Prot: SPIC_HUMAN, Q8N5J4 Tissue specificity : Preferentially detected in fetal and adult spleen, lymph nodes and at lower levels in bone marrowand fetal liver SABiosciences Custom PCR Arrays for SPIC Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SPICBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat SPIC QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SPIC QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SPIC In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPIC
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Orthologsfor SPIC gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for SPIC gene from 3/11 species (see all 11 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
SPIC1
Spi-C transcription factor (Spi-1/PU.1 related)
69.86(n) 65.83(a)
 
427915 XM_425488.2 XP_425488.2
lizard (Anolis carolinensis)
Reptilia
SPIC6
--
56(a)
1 ↔ 1
5(17190674-17196200)
zebrafish (Danio rerio)
Actinopterygii
spic1
Spi-C transcription factor (Spi-1/PU.1 related)
52.43(n) 50(a)
 
447882 NM_001004621.1 NP_001004621.1
ENSEMBL Gene Tree for SPIC (if available)TreeFam Gene Tree for SPIC (if available)
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Paralogsfor SPIC gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for SPIC gene SPIB 2 SPI1 2 3 SIMAP similar genes for SPIC using alignment to 1 protein entry: SPIC_HUMAN :SPI1 ELF5 SPIB
SPIC for paralogs About GeneDecksing 5 Pseudogenes.org Pseudogenes for SPIC PGOHUM00000242206 PGOHUM00000236914 PGOHUM00000237363 PGOHUM00000245808 PGOHUM00000235494
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Genomic Variantsfor SPIC gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 12 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for SPIC (101869199 - 101880775 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for SPIC: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SPIC
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Disorders
/ Diseasesfor SPIC gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
SPIC for disorders About GeneDecksing
OMIM gene information: 612568
OMIM disorders : --2 diseases for SPIC : About MalaCards wolman disease lipomatosis 3 diseases from the University of Copenhagen DISEASES database for SPIC :Wolman disease Dilated cardiomyopathy Lipomatosis Export disorders for SPIC gene to outside databases
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Publicationsfor SPIC gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for SPIC gene integrated from 9 sources : (articles sorted by number of sources associating them with SPIC) Utopia : connect your pdf to the dynamic world of online information
Genomic structure of mouse SPI-C and genomic structure and expression pattern of human SPI-C. (PubMed id 12459275) 1 , 2 , 3 Carlsson R.... Leanderson T. (2002) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 OlA!h J....OvA!di J. (2011) SPI-C and STAT6 can cooperate to stimulate IgE germline transcription. (PubMed id 16647686) 1 Carlsson R....Leanderson T. (2006) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for SPIC gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing SPIC gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing SPIC gene
(According to HUGE )
About This Section --
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Specialized Databases showing SPIC gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for SPIC Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for SPIC gene: Search GeneIP for patents involving SPIC GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor SPIC gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for SPIC OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for SPIC OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SPIC OriGene Protein Over-expression Lysate for SPIC Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for SPIC Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SPIC OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SPIC Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for SPIC OriGene Custom Protein Services for SPIC OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPIC QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SPIC QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPIC QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat SPIC QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SPIC QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SPIC
Search Tocris compounds for SPIC
SPIC Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPIC
ThermoFisher Antibodies for SPIC
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SPIC
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