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SPIB Gene

protein-coding   GIFtS: 53
GCID: GC19P050922

Spi-B Transcription Factor (Spi-1/PU.1 Related)

  See SPIB-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Spi-B Transcription Factor (Spi-1/PU.1 Related)1 2
SPI-B2
Transcription Factor Spi-B2

External Ids:    HGNC: 112421   Entrez Gene: 66892   Ensembl: ENSG000002694047   OMIM: 6068025   UniProtKB: Q018923   

Export aliases for SPIB gene to outside databases

Previous GC identifers: GC19P051551 GC19P051283 GC19P055598 GC19P055614 GC19P047261


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SPIB Gene:
The protein encoded by this gene is a transcriptional activator that binds to the PU-box (5'-GAGGAA-3') and acts
as a lymphoid-specific enhancer. Four transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Sep 2011)

GeneCards Summary for SPIB Gene:
SPIB (Spi-B transcription factor (Spi-1/PU.1 related)) is a protein-coding gene. Diseases associated with SPIB include primary biliary cirrhosis, and blastic plasmacytoid dendritic cell. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ENSG00000142539.

UniProtKB/Swiss-Prot: SPIB_HUMAN, Q01892
Function: Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence
(5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells
(pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells
have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell
receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation

Gene Wiki entry for SPIB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPIB gene promoter:
         AhR   GR   AML1a   GATA-3   STAT5A   Arnt   ARP-1   GR-alpha   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPIB promoter sequence
   Search Chromatin IP Primers for SPIB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPIB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3-q13.4   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3-q13.4

SPIB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPIB gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P050922:  view genomic region     (about GC identifiers)

Start:
50,922,195 bp from pter      End:
50,934,570 bp from pter
Size:
12,376 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SPIB_HUMAN, Q01892 (See protein sequence)
Recommended Name: Transcription factor Spi-B  
Size: 262 amino acids; 28819 Da
Subunit: Can form homotypic interactions. Interacts with IRF4. May also interact with CREBBP, EP300, SPI1/PU.1
related, JUN and TBP
Secondary accessions: A8K9C9 B4DUG6 Q15359
Alternative splicing: 3 isoforms:  Q01892-1   Q01892-2   Q01892-3   

Explore the universe of human proteins at neXtProt for SPIB: NX_Q01892

Explore proteomics data for SPIB at MOPED


See SPIB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (4 alternative transcripts): 
NP_001230927.1  NP_001230928.1  NP_001230929.1  NP_003112.2  

ENSEMBL proteins: 
 ENSP00000471921   ENSP00000469023   ENSP00000470970   ENSP00000472626   ENSP00000270632  
 ENSP00000391877  

SPIB Human Recombinant Protein Products:

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Cloud-Clone Corp. Proteins for SPIB

 
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antibodies-online proteins for SPIB (5 products) 

 
antibodies-online peptides for SPIB

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antibodies-online kits for SPIB (6 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:
 IPR011991 WHTH_DNA-bd_dom
 IPR000418 Ets_dom

Graphical View of Domain Structure for InterPro Entry Q01892

ProtoNet protein and cluster: Q01892

UniProtKB/Swiss-Prot: SPIB_HUMAN, Q01892
Domain: The protein contains a weakly acidic N-terminal transactivation domain (TAD) followed by a second TAD rich
in proline, serine and threonine. Each of these domains may be required for transcriptional activation of a
subset of target genes
Similarity: Belongs to the ETS family
Similarity: Contains 1 ETS DNA-binding domain


Find genes that share domains with SPIB           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: SPIB_HUMAN, Q01892
Function: Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence
(5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells
(pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells
have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell
receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation

     Genatlas biochemistry entry for SPIB:
transcription factor SPI-B,homolog to Spi-1/PU.1 putative oncogene,expressed in various hematopoietic cell lines

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IBA--
GO:0003700sequence-specific DNA binding transcription factor activity ----
GO:0043565sequence-specific DNA binding IEA--
     
Find genes that share ontologies with SPIB           About GenesLikeMe


Phenotypes:
     5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Spib):
 cellular  digestive/alimentary  hematopoietic system  immune system  mortality/aging 

Find genes that share phenotypes with SPIB           About GenesLikeMe

Animal Models:
     MGI mouse knock-outs for SPIB: Spibtm1Ksho Spibtm1Mcs

   genOway: Develop your customized and physiologically relevant rodent model for SPIB

miRNA
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SwitchGear 3'UTR luciferase reporter plasmidSPIB 3' UTR sequence
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
SPIB_HUMAN, Q01892: Isoform 1: Nucleus
SPIB_HUMAN, Q01892: Isoform 2: Cytoplasm
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
cytoskeleton4
plasma membrane1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IBA--
GO:0005737cytoplasm TAS8670269
GO:0015630microtubule cytoskeleton ----

Find genes that share ontologies with SPIB           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPIB
Interactions:

    GeneGlobe Interaction Network for SPIB

STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

Selected Interacting proteins for SPIB (Q018923 ENSP000002706324) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
InteractantInteraction Details
GeneCardExternal ID(s)
JUNP054123, ENSP000003602664I2D: score=2 STRING: ENSP00000360266
SPI1P179473, ENSP000002271634I2D: score=2 STRING: ENSP00000227163
CSNK2A2P197843, ENSP000002625064I2D: score=1 STRING: ENSP00000262506
E2F1Q010943, ENSP000003455714I2D: score=1 STRING: ENSP00000345571
TBPP202263, ENSP000002303544I2D: score=1 STRING: ENSP00000230354
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Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated ----
GO:0006355regulation of transcription, DNA-templated ----
GO:0006357regulation of transcription from RNA polymerase II promoter IBA--
GO:0006366transcription from RNA polymerase II promoter IBA--
GO:0030154cell differentiation IBA--

Find genes that share ontologies with SPIB           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for SPIB

1 Novoseek inferred chemical compound relationship for SPIB gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine 0 1 12384430 (1)



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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for SPIB gene (4 alternative transcripts): 
NM_001243998.1  NM_001243999.1  NM_001244000.1  NM_003121.4  

Unigene Cluster for SPIB:

Spi-B transcription factor (Spi-1/PU.1 related)
Hs.437905  [show with all ESTs]
Unigene Representative Sequence: AK225225
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000595883 ENST00000599923 ENST00000594188 ENST00000597855 ENST00000596074
ENST00000594685 ENST00000270632(uc021uyc.1 uc002psd.3 uc002pse.3 uc010ycc.2)
ENST00000439922
miRNA
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5 qRT-PCR Assays for microRNAs that regulate SPIB:
hsa-miR-875-3p hsa-miR-516b hsa-miR-4330 hsa-miR-491-5p hsa-miR-1299
SwitchGear 3'UTR luciferase reporter plasmidSPIB 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat SPIB
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GenScript: all cDNA clones in your preferred vector: SPIB (NM_003121)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPIB
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPIB
Primer
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OriGene qPCR primer pairs and template standards for SPIB
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPIB
  QuantiTect SYBR Green Assays in human, mouse, rat SPIB
  QuantiFast Probe-based Assays in human, mouse, rat SPIB

Additional mRNA sequence: 

AK025419.1 AK225225.1 AK225720.1 AK292644.1 AK300639.1 BC007921.2 X66079.1 X96998.1 

3 DOTS entries:

DT.408806  DT.121504174  DT.95369332 

Selected AceView cDNA sequences (see all 71):

CR591146 AW474881 BG754034 AW500539 AW500536 AW503820 X66079 NM_003121 
BF794260 BQ057133 BF795477 BM456195 BM152265 AW293044 BM464752 BF663596 
AW182312 BI837556 AW449379 BQ063065 BP368482 BI905846 BM458591 BG025013 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SPIB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGCCTGTACT
SPIB Expression
About this image


SPIB expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 5) fully expand
 
 Blood (Cardiovascular System)    fully expand to see all 5 entries
         Mature B-Cells Peripheral Blood
 
 Adipose (Muscoskeletal System)
         Body Subcutaneous White Adipose
 
 Spleen (Hematopoietic System)
         Conventional Dendritic Cells II Spleen
 
 Tonsil (Hematopoietic System)
 
 Lymph (Hematopoietic System)
SPIB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SPIB Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.437905

UniProtKB/Swiss-Prot: SPIB_HUMAN, Q01892
Tissue specificity: Expressed in plasmacytoid dendritic cells (pDCs) and B-cells, not expressed in T-cells or
granulocytes. May also be enriched in stem cell populations of the liver

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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for SPIB gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Spib1 , 5 Spi-B transcription factor (Spi-1/PU.1 related)1, 5 83.72(n)1
84.73(a)1
  7 (28.83 cM)5
2723821  NM_019866.11  NP_063919.11 
 445259955 
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
36(a)
1 → many
6(79664031-79685740)
African clawed frog
(Xenopus laevis)
Amphibia MGC530202 similar to spleen focus forming virus (SFFV) proviral more 74.47(n)    AF247365.1 
zebrafish
(Danio rerio)
Actinopterygii spi1a6
spleen focus forming virus (SFFV) proviral integra...
36(a)
1 → many
25(36640987-36659690) ENSDARG00000067797


ENSEMBL Gene Tree for SPIB (if available)
TreeFam Gene Tree for SPIB (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SPIB gene
ENSG000001425392  SPIC2  SPI12  
2 SIMAP similar genes for SPIB using alignment to 4 protein entries:     SPIB_HUMAN (see all proteins):
SPI1    SPIC

Find genes that share paralogs with SPIB           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SPIB (see all 271)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs801986141,2
F--50921783(+) CCTCCC/TGTCAC 4 -- us2k11Minor allele frequency- T:0.03WA 118
rs1143774341,2
F--50921784(+) CTCCCG/ATCACC 4 -- us2k11Minor allele frequency- A:0.02WA 118
rs1463028001,2
--50921803(+) CCCCCA/GGGGAG 4 -- us2k10--------
rs743943251,2
F--50921804(+) CCCCGG/AGGAGA 4 -- us2k11Minor allele frequency- A:0.07WA 118
rs1855186231,2
--50921874(+) AGATCC/TTCCGT 4 -- us2k10--------
rs1903300581,2
--50921932(+) CAGGGC/TTCCCC 4 -- us2k10--------
rs777798591,2
C,F--50922030(+) GGCCCG/ACCATC 4 -- us2k13Minor allele frequency- A:0.08CSA WA NA 240
rs1807135591,2
--50922034(+) CGCCAC/TCCCTG 4 -- us2k10--------
rs1854361581,2
C--50922276(+) GGGGTC/TCCCAC 4 -- int10--------
rs24632371,2
C,F,A--50922369(-) AGGGCG/AGACCC 4 -- int11Minor allele frequency- A:0.04WA 118

HapMap Linkage Disequilibrium report for SPIB (50922195 - 50934570 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for SPIB:    About this table    
Variant IDTypeSubtypePubMed ID
esv2661463CNV Deletion23128226
nsv912281CNV Loss21882294
dgv3976n71CNV Loss21882294
nsv912282CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 606802    OMIM disorders: --

2 diseases for SPIB:    
About MalaCards
primary biliary cirrhosis    blastic plasmacytoid dendritic cell

1 disease from the University of Copenhagen DISEASES database for SPIB:
Progressive multifocal leukoencephalopathy

Find genes that share disorders with SPIB           About GenesLikeMe

1 Novoseek inferred disease relationship for SPIB gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia 0.696 2 11841448 (1), 15611260 (1)

Genetic Association Database (GAD): SPIB

Export disorders for SPIB gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SPIB gene, integrated from 10 sources (see all 49):
(articles sorted by number of sources associating them with SPIB)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1. (PubMed id 1406622)1, 2, 3, 9 Ray D....Moreau-Gachelin F. (Mol. Cell. Biol. 1992)
  2. The transcription factor Spi-B is expressed in plasmacytoid DC precursors and inhibits T-, B-, and NK-cell development. (PubMed id 12393575)1, 2, 9 Schotte R.... Spits H. (Blood 2003)
  3. Interaction between the hematopoietic Ets transcription factor Spi-B and the coactivator CREB-binding protein associated with negative cross-talk with c-Myb. (PubMed id 11864910)1, 2, 9 Yamamoto H....Oikawa T. (Cell Growth Differ. 2002)
  4. An alternatively spliced isoform of the Spi-B transcription factor. (PubMed id 8670269)1, 2, 9 Ray-Gallet D.... Moreau-Gachelin F. (Biochem. Biophys. Res. Commun. 1996)
  5. The ETS transcription factor Spi-B is required for human plasmacytoid dendritic cell development. (PubMed id 15583020)1, 2, 9 Schotte R.... Blom B. (J. Exp. Med. 2004)
  6. Expression of transcription factors Pu.1, Spi-B, Blimp-1, BSAP and oct-2 in normal human plasma cells and in multiple myeloma cells. (PubMed id 11841448)1, 2, 9 Nagy M.... Matthes T. (Br. J. Haematol. 2002)
  7. Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. (PubMed id 21399635)1, 4 Mells G.F....Anderson C.A. (Nat. Genet. 2011)
  8. Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis. (PubMed id 20639880)1, 4 Liu X....Seldin M.F. (Nat. Genet. 2010)
  9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  10. SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1. (PubMed id 10196196)1, 2 Rao S.... Simon M.C. (J. Biol. Chem. 1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6689 HGNC: 11242 AceView: SPIB Ensembl:ENSG00000269404 euGenes: HUgn6689
ECgene: SPIB H-InvDB: SPIB

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for SPIB Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SPIB Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SPIB gene:
Search GeneIP for patents involving SPIB

GeneCards and IP:
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