External Ids for SPIB Gene
Previous GeneCards Identifiers for SPIB Gene
The protein encoded by this gene is a transcriptional activator that binds to the PU-box (5'-GAGGAA-3') and acts as a lymphoid-specific enhancer. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
GeneCards Summary for SPIB Gene
SPIB (Spi-B Transcription Factor (Spi-1/PU.1 Related)) is a Protein Coding gene. Diseases associated with SPIB include primary biliary cirrhosis and blastic plasmacytoid dendritic cell. Among its related pathways are NF-kappaB Signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is SPI1.
UniProtKB/Swiss-Prot for SPIB Gene
Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5-GAGGAA-3) that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation.