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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPIB Gene

protein-coding   GIFtS: 54
GCID: GC19P050922

Spi-B Transcription Factor (Spi-1/PU.1 Related)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Spi-B Transcription Factor (Spi-1/PU.1 Related)1 2
SPI-B2
Transcription Factor Spi-B2

External Ids:    HGNC: 112421   Entrez Gene: 66892   Ensembl: ENSG000002694047   OMIM: 6068025   UniProtKB: Q018923   

Export aliases for SPIB gene to outside databases

Previous GC identifers: GC19P051551 GC19P051283 GC19P055598 GC19P055614 GC19P047261


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SPIB Gene:
The protein encoded by this gene is a transcriptional activator that binds to the PU-box (5'-GAGGAA-3') and acts
as a lymphoid-specific enhancer. Four transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Sep 2011)

GeneCards Summary for SPIB Gene: 
SPIB (Spi-B transcription factor (Spi-1/PU.1 related)) is a protein-coding gene. Diseases associated with SPIB include progressive multifocal leukoencephalopathy, and primary biliary cirrhosis. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is SPIC.

UniProtKB/Swiss-Prot: SPIB_HUMAN, Q01892
Function: Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence
(5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells
(pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells
have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell
receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation

Gene Wiki entry for SPIB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPIB gene promoter:
         AhR   GR   AML1a   GATA-3   STAT5A   Arnt   ARP-1   GR-alpha   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPIB promoter sequence
   Search SABiosciences Chromatin IP Primers for SPIB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPIB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3-q13.4   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3-q13.4

SPIB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPIB gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P050922:  view genomic region     (about GC identifiers)

Start:
50,922,195 bp from pter      End:
50,934,570 bp from pter
Size:
12,376 bases      Orientation:
plus strand

1 alternative location:
Chr19+ 50,919,056-50,931,844     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SPIB_HUMAN, Q01892 (See protein sequence)
Recommended Name: Transcription factor Spi-B  
Size: 262 amino acids; 28819 Da
Subunit: Can form homotypic interactions. Interacts with IRF4. May also interact with CREBBP, EP300, SPI1/PU.1
related, JUN and TBP
Subcellular location: Isoform 1: Nucleus
Subcellular location: Isoform 2: Cytoplasm
Secondary accessions: A8K9C9 B4DUG6 Q15359
Alternative splicing: 3 isoforms:  Q01892-1   Q01892-2   Q01892-3   

Explore the universe of human proteins at neXtProt for SPIB: NX_Q01892

Explore proteomics data for SPIB at MOPED 

SPIB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

SPIB Protein Expression

REFSEQ proteins (4 alternative transcripts): 
NP_001230927.1  NP_001230928.1  NP_001230929.1  NP_003112.2  

ENSEMBL proteins: 
 ENSP00000471921   ENSP00000469023   ENSP00000470970   ENSP00000472626   ENSP00000270632  

Human Recombinant Protein Products for SPIB: 
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OriGene Protein Over-expression Lysate for SPIB
OriGene Custom MassSpec 
OriGene Custom Protein Services for SPIB
GenScript Custom Purified and Recombinant Proteins Services for SPIB
Novus Biologicals SPIB Protein
Novus Biologicals SPIB Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for SPIB 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--
GO:0005737cytoplasm TAS8670269
GO:0015630microtubule cytoskeleton IDA--

SPIB for ontologies           About GeneDecksing



SPIB Antibody Products: 
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Abcam antibodies for SPIB
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ThermoFisher Antibody for SPIB
LSBio Antibodies in human, mouse, rat for SPIB 

Assay Products for SPIB: 
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Cloud-Clone Corp. ELISAs for SPIB 
Cloud-Clone Corp. CLIAs for SPIB


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
2 InterPro protein domains:
 IPR011991 WHTH_DNA-bd_dom
 IPR000418 Ets_dom

Graphical View of Domain Structure for InterPro Entry Q01892

ProtoNet protein and cluster: Q01892

UniProtKB/Swiss-Prot: SPIB_HUMAN, Q01892
Domain: The protein contains a weakly acidic N-terminal transactivation domain (TAD) followed by a second TAD rich
in proline, serine and threonine. Each of these domains may be required for transcriptional activation of a
subset of target genes
Similarity: Belongs to the ETS family
Similarity: Contains 1 ETS DNA-binding domain


SPIB for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: SPIB_HUMAN, Q01892
Function: Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence
(5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells
(pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells
have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell
receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation

     Genatlas biochemistry entry for SPIB:
transcription factor SPI-B,homolog to Spi-1/PU.1 putative oncogene,expressed in various hematopoietic cell lines

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
GO:0043565sequence-specific DNA binding IEA--
     
SPIB for ontologies           About GeneDecksing


Phenotypes:
     5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Spib):
 cellular  digestive/alimentary  hematopoietic system  immune system  mortality/aging 

SPIB for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for SPIB: Spibtm1Ksho Spibtm1Mcs

   inGenious Targeting Laboratory - Custom generated mouse model solutions for SPIB 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SPIB

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPIB 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPIB 

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPIB
5 QIAGEN miScript miRNA Assays for microRNAs that regulate SPIB:
hsa-miR-875-3p hsa-miR-516b hsa-miR-4330 hsa-miR-491-5p hsa-miR-1299
SwitchGear 3'UTR luciferase reporter plasmidSPIB 3' UTR sequence
Inhib. RNA
Products:
    
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OriGene RNAi products in human, mouse, rat for SPIB
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPIB

Gene Editing
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Clone
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OriGene clones in human, mouse for SPIB (see all 9)
OriGene ORF clones in mouse, rat for SPIB
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: SPIB (NM_003121)
Sino Biological Human cDNA Clone for SPIB
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPIB
Sirion Biotech Customized lentivirus for stable overexpression of SPIB 
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Cell Line
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Search LifeMap BioReagents cell lines for SPIB
In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPIB


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section




Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SPIB

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

5/17 Interacting proteins for SPIB (Q018923 ENSP000002706324) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
InteractantInteraction Details
GeneCardExternal ID(s)
JUNP054123, ENSP000003602664I2D: score=2 STRING: ENSP00000360266
SPI1P179473, ENSP000002271634I2D: score=2 STRING: ENSP00000227163
CSNK2A2P197843, ENSP000002625064I2D: score=1 STRING: ENSP00000262506
E2F1Q010943, ENSP000003455714I2D: score=1 STRING: ENSP00000345571
TBPP202263, ENSP000002303544I2D: score=1 STRING: ENSP00000230354
About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-dependent IEA--
GO:0006355regulation of transcription, DNA-dependent ----
GO:0006357regulation of transcription from RNA polymerase II promoter TAS1406622
GO:0030225macrophage differentiation IEA--

SPIB for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SPIB for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SPIB

1 Novoseek inferred chemical compound relationship for SPIB gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine 0 1 12384430 (1)

Search CenterWatch for drugs/clinical trials and news about SPIB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SPIB gene (4 alternative transcripts): 
NM_001243998.1  NM_001243999.1  NM_001244000.1  NM_003121.4  

Unigene Cluster for SPIB:

Spi-B transcription factor (Spi-1/PU.1 related)
Hs.437905  [show with all ESTs]
Unigene Representative Sequence: AK225225
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000595883 ENST00000599923 ENST00000594188 ENST00000597855 ENST00000596074
ENST00000594685 ENST00000270632(uc021uyc.1 uc002psd.3 uc002pse.3 uc010ycc.2)

Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
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5 QIAGEN miScript miRNA Assays for microRNAs that regulate SPIB:
hsa-miR-875-3p hsa-miR-516b hsa-miR-4330 hsa-miR-491-5p hsa-miR-1299
SwitchGear 3'UTR luciferase reporter plasmidSPIB 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for SPIB
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPIB
Clone
Products:
     
OriGene clones in human, mouse for SPIB (see all 9)
OriGene ORF clones in mouse, rat for SPIB
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: SPIB (NM_003121)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPIB
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPIB
Sirion Biotech Customized lentivirus for stable overexpression of SPIB 
                     Customized lentivirus expression plasmids for stable overexpression of SPIB 
Primer
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OriGene qPCR primer pairs and template standards for SPIB
OriGene qSTAR qPCR primer pairs in human, mouse for SPIB
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPIB
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPIB
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPIB

Additional mRNA sequence: 

AK025419.1 AK225225.1 AK225720.1 AK292644.1 AK300639.1 BC007921.2 X66079.1 X96998.1 

3 DOTS entries:

DT.408806  DT.121504174  DT.95369332 

24/71 AceView cDNA sequences (see all 71):

CR591146 AW474881 BM464752 BF794260 AW449379 AW500536 BF663596 X66079 
BQ063065 AW503820 BG754034 AW403726 AL582076 BF795477 AW500539 BM152265 
BI837556 BM456195 BP368482 BI905846 BM458591 BG025013 AW404895 X96998 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SPIB expression in normal human tissues (normalized intensities)      SPIB embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGCCTGTACT
SPIB Expression
About this image


SPIB expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/5 selected tissues (see all 5) fully expand
 
 Blood (Hematopoietic System)    fully expand to see all 5 entries
         Plasmacytoid Dendritic cells Peripheral Blood
         b cells   
 
 Lymph (Hematopoietic System)    fully expand to see all 2 entries
         LYMPH NODE   
 
 Adipose (Muscoskeletal System)
         Body Subcutaneous White Adipose
 
 Spleen (Hematopoietic System)
         Conventional Dendritic Cells II Spleen
 
 Tonsil (Hematopoietic System)

See SPIB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPIB

SOURCE GeneReport for Unigene cluster: Hs.437905

UniProtKB/Swiss-Prot: SPIB_HUMAN, Q01892
Tissue specificity: Expressed in plasmacytoid dendritic cells (pDCs) and B-cells, not expressed in T-cells or
granulocytes. May also be enriched in stem cell populations of the liver

    SABiosciences Custom PCR Arrays for SPIB
Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPIB
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPIB

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for SPIB gene from 4/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Spib1 , 5 Spi-B transcription factor (Spi-1/PU.1 related)1, 5 83.72(n)1
85.38(a)1
  7 (28.83 cM)5
2723821  NM_019866.11  NP_063919.11 
 445259955 
lizard
(Anolis carolinensis)
Reptilia --
--
32(a)
1 → many
6(79664031-79685740)
African clawed frog
(Xenopus laevis)
Amphibia MGC530202 similar to spleen focus forming virus (SFFV) proviral more 74.47(n)    AF247365.1 
zebrafish
(Danio rerio)
Actinopterygii spi1a6
CT868708.16
Uncharacterized protein
36(a)
30(a)
many → 1
possible ortholog
25(36640987-36659668)
4(16869976-16873104)


ENSEMBL Gene Tree for SPIB (if available)
TreeFam Gene Tree for SPIB (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for SPIB gene
SPIC2  SPI12  
3 SIMAP similar genes for SPIB using alignment to 5 protein entries:     SPIB_HUMAN (see all proteins):
POLD1    SPI1    SPIC

SPIB for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/271 SNPs in SPIB are shown (see all 271)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs801986141,2
F--50921783(+) CCTCCC/TGTCAC 4 -- us2k11Minor allele frequency- T:0.03WA 118
rs1143774341,2
F--50921784(+) CTCCCG/ATCACC 4 -- us2k11Minor allele frequency- A:0.02WA 118
rs1463028001,2
--50921803(+) CCCCCA/GGGGAG 4 -- us2k10--------
rs743943251,2
F--50921804(+) CCCCGG/AGGAGA 4 -- us2k11Minor allele frequency- A:0.07WA 118
rs1855186231,2
--50921874(+) AGATCC/TTCCGT 4 -- us2k10--------
rs1903300581,2
--50921932(+) CAGGGC/TTCCCC 4 -- us2k10--------
rs777798591,2
C,F--50922030(+) GGCCCG/ACCATC 4 -- us2k13Minor allele frequency- A:0.08CSA WA NA 240
rs1807135591,2
--50922034(+) CGCCAC/TCCCTG 4 -- us2k10--------
rs1854361581,2
C--50922276(+) GGGGTC/TCCCAC 4 -- int10--------
rs24632371,2
C,F,A--50922369(-) AGGGCG/AGACCC 4 -- int11Minor allele frequency- A:0.04WA 118

HapMap Linkage Disequilibrium report for SPIB (50922195 - 50934570 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for SPIB:    About this table     
Variant IDTypeSubtypePubMed ID
esv2661463CNV Deletion23128226
nsv912281CNV Loss21882294
dgv3976n71CNV Loss21882294
nsv912282CNV Loss21882294

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SeqTarget long-range PCR primers for resequencing SPIB
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 606802    OMIM disorders: --

8 diseases for SPIB:    About MalaCards
progressive multifocal leukoencephalopathy    primary biliary cirrhosis    burkitt's lymphoma    multiple myeloma
myeloma    diffuse large b-cell lymphoma    b-cell lymphomas    leukemia

1 disease from the University of Copenhagen DISEASES database for SPIB:
Progressive multifocal leukoencephalopathy

SPIB for disorders           About GeneDecksing

1 Novoseek inferred disease relationship for SPIB gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia 0.696 2 11841448 (1), 15611260 (1)

Genetic Association Database (GAD): SPIB

Export disorders for SPIB gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for SPIB gene, integrated from 9 sources (see all 49):
(articles sorted by number of sources associating them with SPIB)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1. (PubMed id 1406622)1, 2, 3, 9 Ray D....Moreau-Gachelin F. (1992)
  2. The transcription factor Spi-B is expressed in plasmacytoid DC precursors and inhibits T-, B-, and NK-cell development. (PubMed id 12393575)1, 2, 9 Schotte R.... Spits H. (2003)
  3. Interaction between the hematopoietic Ets transcription factor Spi-B and the coactivator CREB-binding protein associated with negative cross-talk with c-Myb. (PubMed id 11864910)1, 2, 9 Yamamoto H....Oikawa T. (2002)
  4. An alternatively spliced isoform of the Spi-B transcription factor. (PubMed id 8670269)1, 2, 9 Ray-Gallet D.... Moreau-Gachelin F. (1996)
  5. The ETS transcription factor Spi-B is required for human plasmacytoid dendritic cell development. (PubMed id 15583020)1, 2, 9 Schotte R.... Blom B. (2004)
  6. Expression of transcription factors Pu.1, Spi-B, Blimp-1, BSAP and oct-2 in normal human plasma cells and in multiple myeloma cells. (PubMed id 11841448)1, 2, 9 Nagy M.... Matthes T. (2002)
  7. Genome-wide association study identifies 12 new susce ptibility loci for primary biliary cirrhosis. (PubMed id 21399635)1, 4 Mells G.F....Anderson C.A. (2011)
  8. Genome-wide meta-analyses identify three loci associa ted with primary biliary cirrhosis. (PubMed id 20639880)1, 4 Liu X....Seldin M.F. (2010)
  9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  10. SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1. (PubMed id 10196196)1, 2 Rao S.... Simon M.C. (1999)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6689 HGNC: 11242 AceView: SPIB Ensembl:ENSG00000269404 euGenes: HUgn6689
ECgene: SPIB H-InvDB: SPIB

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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NameDescription
PharmGKB entry for SPIB Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SPIB Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
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