SPIB Gene

Aliases
for SPIB gene

Previous GC identifers: GC19P051551 GC19P051283 GC19P055598 GC19P055614 GC19P047261

Summaries
for SPIB gene

Genomic Views
for SPIB gene

RefSeq DNA sequence:

NC_000019.9  NC_018930.1  NT_011109.16  

SwitchGear Promoter luciferase reporter plasmid: SPIB promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPIB

SPIB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P050922:  view genomic region     (about GC identifiers)

Proteins
for SPIB gene

Explore the universe of human proteins at neXtProt for SPIB: NX_Q01892

SPIB Protein expression data from MOPED and PaxDb:    About this image 

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: SPIB OriGene Custom Protein Services for SPIB
	GenScript Custom Purified and Recombinant Proteins Services for SPIB
	Novus Biologicals SPIB Protein Novus Biologicals SPIB Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SPIB

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for SPIB (Spi-B)
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	GenScript Custom Superior Antibodies Services for SPIB
	Novus Biologicals SPIB Antibody
	Search for Antibodies for SPIB at Abcam
	Uscn Antibodies for SPIB
	ThermoFisher Antibodies for SPIB

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SPIB
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SPIB

Protein Domains /
Families
for SPIB gene

ProtoNet protein and cluster: Q01892

Function
for SPIB gene

miRNA Products:		OriGene 3'-UTR Clone: SPIB Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPIB
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate SPIB:
		hsa-miR-875-3p hsa-miR-516b hsa-miR-4330 hsa-miR-491-5p hsa-miR-1299
		SwitchGear 3'UTR luciferase reporter plasmid: SPIB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPIB (see all 7) OriGene shRNA RFP: SPIB OriGene siRNA: SPIB
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPIB

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for SPIB

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPIB (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPIB (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SPIB (NM_003121)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPIB
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPIB

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SPIB
		Search LifeMap BioReagents cell lines for SPIB

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPIB

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

(inferred from 2 alleles) (MGI details for Spib)

Pathways & Interactions
for SPIB gene

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for SPIB gene

Transcripts
for SPIB gene

Expression
for SPIB gene

SPIB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCCTGTACT

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	AdiposeBody Subcutaneous White Adipose			Adipose
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPIB Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPIB
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPIB
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPIB

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPIB

Orthologs
for SPIB gene

Paralogs
for SPIB gene

Paralogs for SPIB gene

SPI1²  SPIC²  

2 SIMAP similar genes for SPIB using alignment to 5 protein entries:     SPIB_HUMAN (see all proteins):

SPI1    SPIC

SPIB for paralogs           About GeneDecksing

Genomic Variants
for SPIB gene

10/205 NCBI SNPs in SPIB are shown (see all 205)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs801986141,2	F,	--	50921783(+)	CCTCCC/TGTCAC	4	--	us2k1		1		WA	118
rs1143774341,2	F,	--	50921784(+)	CTCCCG/ATCACC	4	--	us2k1		1		WA	118
rs1463028001,2		--	50921803(+)	CCCCCA/GGGGAG	4	--	us2k1		0	--	--	--	--
rs743943251,2	F,	--	50921804(+)	CCCCGG/AGGAGA	4	--	us2k1		1		WA	118
rs1855186231,2		--	50921874(+)	AGATCC/TTCCGT	4	--	us2k1		0	--	--	--	--
rs1903300581,2		--	50921932(+)	CAGGGC/TTCCCC	4	--	us2k1		0	--	--	--	--
rs777798591,2		--	50922030(+)	GGCCCG/ACCATC	4	--	us2k1		3		CSA WA NA	240
rs1807135591,2		--	50922034(+)	CGCCAC/TCCCTG	4	--	us2k1		0	--	--	--	--
rs1854361581,2	C,	--	50922276(+)	GGGGTC/TCCCAC	4	--	int1		0	--	--	--	--
rs24632371,2	C,F,A,	--	50922369(-)	AGGGCG/AGACCC	4	--	int1		1		WA	118

HapMap Linkage Disequilibrium report for SPIB (50922195 - 50932250 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for SPIB: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPIB

DNA2.0 Custom Variant and Variant Library Synthesis for SPIB

Disorders / Diseases
for SPIB gene

6 diseases for SPIB

1 Novoseek disease relationship for SPIB gene    About this table

Publications
for SPIB gene

PubMed articles for SPIB gene, integrated from 9 sources (see all 45): (articles sorted by number of sources associating them with SPIB)

Utopia: connect your pdf to the dynamic world of online information

1. Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1. (PubMed id 1406622)^{1, 2, 3, 9} Ray D....Moreau-Gachelin F. (1992)
2. The transcription factor Spi-B is expressed in plasmacytoid DC precursors and inhibits T-, B-, and NK-cell development. (PubMed id 12393575)^{1, 2, 9} Schotte R.... Spits H. (2003)
3. Interaction between the hematopoietic Ets transcription factor Spi-B and the coactivator CREB-binding protein associated with negative cross-talk with c-Myb. (PubMed id 11864910)^{1, 2, 9} Yamamoto H....Oikawa T. (2002)
4. An alternatively spliced isoform of the Spi-B transcription factor. (PubMed id 8670269)^{1, 2, 9} Ray-Gallet D.... Moreau-Gachelin F. (1996)
5. The ETS transcription factor Spi-B is required for human plasmacytoid dendritic cell development. (PubMed id 15583020)^{1, 2, 9} Schotte R.... Blom B. (2004)
6. Expression of transcription factors Pu.1, Spi-B, Blimp-1, BSAP and oct-2 in normal human plasma cells and in multiple myeloma cells. (PubMed id 11841448)^{1, 2, 9} Nagy M.... Matthes T. (2002)
7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
8. SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1. (PubMed id 10196196)^{1, 2} Rao S.... Simon M.C. (1999)
9. Differential phosphorylations of Spi-B and Spi-1 transcription factors. (PubMed id 8632909)^{1, 9} Mao C....Moreau-Gachelin F. (1996)
10. Phosphorylation of the Spi-B transcription factor reduces its intrinsic stability. (PubMed id 10618498)^{1, 9} Ray-Gallet D. and Moreau-Gachelin F. (1999)

External Searches for SPIB gene

Genome Databases showing SPIB gene

Other Databases showing SPIB gene

Specialized Databases showing SPIB gene

Products
for SPIB gene