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SPI1 Gene

protein-coding GIFtS: 62

GC11M047332

spleen focus forming virus (SFFV) proviral integration oncogene spi1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
OF ^¹, ²
PU.1 ^¹, ²
SFPI1 ^¹, ², ⁵
SPI-1 ^¹, ²
SPI-A ^¹, ²

Descriptions
31 kDa transforming protein ^²
31 kDa-transforming protein ^³
SPI-1 proto-oncogene ^²
hematopoietic transcription factor PU.1 ^²
spleen focus forming virus (SFFV) proviral integration oncogene spi1 ^²
spleen focus forming virus proviral integration oncogene spi1 ^¹

External Ids
HGNC: 11241¹
Entrez Gene: 6688²
UniProtKB: P17947³
Ensembl: ENSG00000066336⁷

Search outside databases for aliases for SPI1 gene

Previous GC identifers: GC11M049316 GC11M048254 GC11M047408 GC11M047340

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for SPI1:

This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid

and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the

PU-box found near the promoters of target genes, and regulates their expression in coordination

with other transcription factors and cofactors. The protein can also regulate alternative splicing

of target genes. Multiple transcript variants encoding different isoforms have been found for this

gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: SPI1_HUMAN, P17947

Function: Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a

lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically

involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may

modulate pre-mRNA splicing (By similarity)

Gene Wiki entry for SPI1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SPI1 gene

Entrez Gene cytogenetic band: 11p11.2 Ensembl cytogenetic band: 11p11.2 HGNC cytogenetic band: 11p12-p11.22

SPI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M047332: (about GC identifiers)

Start:	47,332,985 bp from pter
End:	47,356,703 bp from pter
Size:	23,719 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000011.8 NT_009237.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: SPI1_HUMAN, P17947 (See protein sequence)

Recommended Name: Transcription factor PU.1

Size: 270 amino acids; 31083 Da

Subunit: Binds DNA as a monomer. Interacts with RUNX1 and SPIB. Interacts with CEBPD and NONO (By

similarity)

Subcellular location: Nucleus

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001074016.1 NP_003111.2

ENSEMBL proteins:

ENSP00000367799 ENSP00000227163

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (PU.1/Spi1)
	Human Recombinant Proteins from Abnova (SPI1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

About this table

Antibodies for SPI1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for SPI1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for SPI1 (PU.1)
	Antibodies from Abcam (PU.1/Spi1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (SPI1)
	Novus Biologicals Antibodies for SPI1

Assays for SPI1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P17947

ProtoNet protein and cluster: P17947

UniProtKB/Swiss-Prot: SPI1_HUMAN, P17947

Similarity: Belongs to the ETS family

Similarity: Contains 1 ETS DNA-binding domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SPI1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SPI1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003120

Applied Biosystems Silencer® siRNAs for SPI1

Sigma-Aldrich siRNA for SPI1

Sigma-Aldrich shRNA for SPI1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001080547
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001080547
untagged cDNA clones in CMV expression vector (see all 3): NM_001080547

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001080547

UniProtKB/Swiss-Prot: SPI1_HUMAN, P17947

Function: Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a

lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically

involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may

modulate pre-mRNA splicing (By similarity)

Induction: Highly expressed in both FV-P and FV-A-induced erythro-leukemia cell lines that have

undergone rearrangements of the Spi-1 gene due to the insertion of SFFV

Genatlas biochemistry entry for SPI1:

spleen focus forming virus (SFFV) proviral integration oncogene spi1,Pu-1 homolog,expressed in

various hemapoietic cell lines,required for the development of both myeloid and lymphoid lineages

15/16 MGI mutant phenotypes (inferred from 16 alleles) (MGI details for Sfpi1) (see all 16 ):

cellular	craniofacial	growth/size	hematopoietic system	homeostasis/metabolism
immune system	lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging	liver/biliary system
nervous system	no phenotypic analysis	normal	skeleton	tumorigenesis

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	TAS	2180582 10867017
GO:0003723	RNA binding	IEA	--
GO:0005515	protein binding	IPI	10207087
GO:0043565	sequence-specific DNA binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for SPI1 (Your Favorite Gene powered by Ingenuity)

Acute Myeloid Leukemia Signaling
IL-12 Signaling and Production in Macrophages

GeneDecks SPI1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for SPI1

5/119 Interacting proteins for SPI1 (ENSP00000367799³) via UniProtKB, MINT, and/or STRING (see all 119 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IRF8	ENSP00000268638³	STRING (score=.996)
GATA1	ENSP00000365858³	STRING (score=.993)
GATA2	ENSP00000345681³	STRING (score=.993)
RUNX1	ENSP00000300305³	STRING (score=.993)
FLT3	ENSP00000370369³	STRING (score=.99)

About this table

5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	TAS	10867017
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0043193	positive regulation of gene-specific transcription	IDA	12833137
GO:0045646	regulation of erythrocyte differentiation	IMP	12833137

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for SPI1
3 Novoseek chemical compound relationships for SPI1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	17.77	6	18794139 (1), 7478542 (1), 17361223 (1), 11865067 (1)
leucine	13.17	1	16931285 (1)
proline	0.00	2	11823535 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SPI1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SPI1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003120

Sigma-Aldrich siRNA for SPI1

Sigma-Aldrich shRNA for SPI1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001080547 NM_003120

REFSEQ mRNAs for SPI1 gene (2 alternative transcripts):

NM_001080547.1 NM_003120.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001080547 NM_003120

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001080547
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001080547
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001080547

Additional cDNA sequence:

AK310065.1 CR599683.1 CR606393.1 CR613003.1 CR615071.1 CR625357.1 X52056.1

10 DOTS entries:

DT.212447 DT.95110804 DT.91688064 DT.100814731 DT.86855596 DT.91889222 DT.95329601 DT.91688065

DT.92034201 DT.92059421

24/114 AceView cDNA sequences (see all 114 ):

BI909431 CR613003 CR599683 BQ231837 CR625357 BI909430 CR615071 BM726188

BM701185 CD368540 BQ055885 BM994691 CA306592 N98848 CA308306 NM_003120

CD368431 AW404793 CD365998 BM919205 BI908495 CD370153 BI906692 CD743247

highest scoring ESTs for SPI1:

X52056 AA227631 AA236102 AL547039 AL547842 AL552267 AW404793 AW976120 BE396543 BF903119

Unigene Cluster for SPI1:

Spleen focus forming virus (SFFV) proviral integration oncogene spi1

Hs.502511 [show with all ESTs]

Unigene Representative Sequence: NM_001080547

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for SPI1

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5a	·	5b	^	6	^	7a	·	7b
SP1:
SP2:
SP3:					-		-

About this scheme

ECgene alternative splicing isoforms for SPI1

2 Ensembl transcripts including schematic representations:

ENST00000378538 ENST00000227163

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

SPI1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SPI1

¹ / ² / ³

3 probe-sets matching SPI1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1341_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X52056	1.00	1.00	1.00	1
205312_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003120	0.60	1.00	0.82	1
205312_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAGGACAGCA

SOURCE GeneReport for Unigene cluster: Hs.502511
Expression variation in blood from EXPOLDB for SPI1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SPI1 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SPI1¹	--	spleen focus forming virus (SFFV) proviral integration more	91.73(n) 96.67(a)	611255 XM_848897.1 XP_853990.1
cow (Bos taurus)	SPI1¹	--	spleen focus forming virus (SFFV) proviral integration more	92.94(n) 95.91(a)	507100 XM_583654.3 XP_583654.3
rat (Rattus norvegicus)	Sfpi1¹	--	SFFV proviral integration 1	88.27(n) 89.26(a)	366126 NM_001005892.2 NP_001005892.1
mouse (Mus musculus)	Sfpi1^{1, 5}	2 (47.50 cM)⁵	SFFV proviral integration 1^{1, 5}	88.02(n)¹ 88.52(a)¹	20375¹ NM_011355.1¹ NP_035485.1¹ AK142246⁵ AK153524⁵ (see all 13)
chicken (Gallus gallus)	SPI1¹	--	spleen focus forming virus (SFFV) proviral integration more	77.73(n) 83.2(a)	395879 NM_205023.1 NP_990354.1

About this table Species with no ortholog for SPI1

ENSEMBL Gene Tree for SPI1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for SPI1 gene

SPIB² SPIC²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/180 NCBI SNPs in SPI1 are shown (see all 180 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 70)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1057233^1,2	A,C,F,H	47333024(-)	`ATTAAT/CCTCCT`	2	--	ut3¹		5		EA EU WA	1696
--	rs11601603^1,2	C,F,H	47357747(+)	`aacccA/Ctccat`	2	--	ng3¹ tfbs³		1		EU	120
	rs3740686^1,2	A,C,F	47332939(+)	`GGCCAG/AAAGAG`	2	--	ng5¹		1		EA	1300
	rs3758675^1,2	C,F	47357178(+)	`GCATAG/ATGCTG`	2	--	ng3¹		2		NA	182
--	rs11607981^1,2	C	47357636(+)	`ACAATG/Tccatc`	2	--	ng3¹		0	--	--	--	--
--	rs3197824^1,2	H	47333571(-)	`CACCTT/GCCAGT`	2	C/F	mis¹		4		EU EA WA	404
--	rs11601173^1,2	C	47357634(+)	`CCACAA/GTtcca`	2	--	ng3¹		0	--	--	--	--
	rs896817^1,2	A,C,F,H,O	47350881(-)	`AGGACG/AAGGCC`	2	--	int¹		8		EU EA WA NA	774
	rs4752830^1,2	A,C,F,H	47353279(+)	`gccacG/Agttag`	2	--	int¹		4		EU EA WA	412
	rs10838698^1,2	A,C,F,H	47342499(+)	`TAACAA/GGATCC`	2	--	int¹		4		EU EA WA	392

About this table

HapMap Linkage Disequilibrium images for SPI1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 165170

10/13 Novoseek disease relationships for SPI1 gene (see all 13 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
erythroleukemia	72.47	11	8502483 (3), 2338340 (2), 1620109 (1), 2044959 (1) (see all 8)
leukemogenesis	42.94	4	17361223 (1), 15910240 (1)
leukemia	37.62	6	16909135 (1), 16735999 (1), 11841448 (1), 16158816 (1) (see all 6)
microphthalmia	31.16	2	15304486 (1), 16109714 (1)
hodgkin disease	30.77	9	15339679 (4), 11696441 (1), 16648862 (1), 15796964 (1)
myeloid leukemia	29.35	4	9826539 (1), 12393465 (1)
lymphoma b-cell	23.76	6	15339679 (4), 12507907 (1), 15202521 (1)
plasmacytoma	20.60	2	7670114 (1)
leukemia t-cell	16.71	1	9376596 (1)
retinoblastoma	0.34	1	8434021 (1)

About this table

Tumor Gene Database: SPI1

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/193 PubMed articles for SPI1 gene (see all 193 ):

The human homologue of the putative proto-oncogene Spi-1: characterization and expression in tumors. (PubMed id 1693183)^{1, 2, 3, 4} Ray D.... Moreau-Gachelin F. (1990)
Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias. (PubMed id 10207087)^{3, 4} Mao S.... Nimer S.D. (1999)
SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1. (PubMed id 10196196)^{3, 4} Rao S.... Simon M.C. (1999)
The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia. (PubMed id 12393465)^{1, 3} Vangala R.K....Behre G. (2003)
Carrier-independent nuclear import of the transcription factor PU.1 via RanGTP-stimulated binding to Nup153. (PubMed id 15632149)^{1, 3} Zhong H....Yaseen N.R. (2005)
Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1. (PubMed id 10411939)^{1, 3} Zhang P....Sun Z. (1999)
PU.1 regulates the tissue-specific expression of dendritic cell-specific intercellular adhesion molecule (ICAM)-3-grabbing nonintegrin. (PubMed id 16051608)^{1, 3} Dominguez-Soto A....Corbi A.L. (2005)
Localization of the human oncogene SPI1 on chromosome 11, region p11.22. (PubMed id 2338340)^{1, 3} Nguyen V.C....Moreau-Gachelin F. (1990)
Human T-cell leukemia virus type I Tax transactivates the promoter of human prointerleukin-1beta gene through association with two transcription factors, nuclear factor-interleukin-6 and Spi-1. (PubMed id 9376596)^{1, 3} Tsukada J....Eto S. (1997)
Differential phosphorylations of Spi-B and Spi-1 transcription factors. (PubMed id 8632909)^{1, 3} Mao C....Moreau-Gachelin F. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6688	HGNC: 11241	AceView: SPI1	Ensembl:ENSG00000066336	euGenes: HUgn6688
ECgene: SPI1	H-InvDB: SPI1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for SPI1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for SPI1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for SPI1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SPI1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SPI1		Antibodies for SPI1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for SPI1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (SPI1)
	Antibodies (SPI1)
	Chimera RNAi (SPI1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for SPI1 (PU.1)

	Recombinant Proteins (PU.1/Spi1)
	Antibodies (PU.1/Spi1)

Search OriGene for SPI1

Search Tocris compounds for SPI1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for SPI1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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SPI1 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for SPI1

Summaries
for SPI1

Genomic Location
for SPI1

Proteins
for SPI1

Protein Domains/
Families
for SPI1

Gene Function
for SPI1

Pathways & Interactions
for SPI1

Drugs & Compounds
for SPI1

Transcripts
for SPI1

Expression
for SPI1

Orthologs
for SPI1

Paralogs
for SPI1

SNPs/Variants
for SPI1

Disorders & Mutations
for SPI1

Medical News
for SPI1

Publications
for SPI1

Search for SPI1

Genome Databases showing SPI1

Other Databases showing SPI1

Specialized Databases showing SPI1

Licensable Technologies
for SPI1

Services
for SPI1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SPI1 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor SPI1

Summariesfor SPI1

Genomic Locationfor SPI1

Proteinsfor SPI1

Protein Domains/Familiesfor SPI1

Gene Functionfor SPI1

Pathways & Interactionsfor SPI1

Drugs & Compoundsfor SPI1

Transcriptsfor SPI1

Expression for SPI1

Orthologsfor SPI1

Paralogsfor SPI1

SNPs/Variantsfor SPI1

Disorders & Mutationsfor SPI1

Medical Newsfor SPI1

Publicationsfor SPI1

Search for SPI1

Genome Databases showing SPI1

Other Databases showing SPI1

Specialized Databases showing SPI1

Licensable Technologiesfor SPI1

Servicesfor SPI1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SPI1

Summaries
for SPI1

Genomic Location
for SPI1

Proteins
for SPI1

Protein Domains/
Families
for SPI1

Gene Function
for SPI1

Pathways & Interactions
for SPI1

Drugs & Compounds
for SPI1

Transcripts
for SPI1

Expression
for SPI1

Orthologs
for SPI1

Paralogs
for SPI1

SNPs/Variants
for SPI1

Disorders & Mutations
for SPI1

Medical News
for SPI1

Publications
for SPI1

Licensable Technologies
for SPI1

Services
for SPI1