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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SPHKAP Gene

protein-coding GIFtS: 47
GCID: GC02M228844

SPHK1 interactor, AKAP domain containing

Explore 2 diseases affiliated with
SPHKAP via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
SPHK1 Interactor, AKAP Domain Containing¹ ²		KIAA1678³ ⁵
SKIP¹ ² ³ ⁵		A-Kinase Anchor Protein SPHKAP²
Sphingosine Kinase Type 1-Interacting Protein² ³		SPHK1 (Sphingosine Kinase Type 1) Interacting Protein²
SPHK1-Interactor And AKAP Domain-Containing Protein² ³

External Ids:	HGNC: 30619¹	Entrez Gene: 80309²	Ensembl: ENSG00000153820⁷	OMIM: 611646⁵	UniProtKB: Q2M3C7³

Export aliases for SPHKAP gene to outside databases

Previous GC identifers: GC02M228553 GC02M220686

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SPKAP_HUMAN, Q2M3C7

Function: Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein

kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP

and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SPHKAP gene promoter:
AP-2rep LHX3b/Lhx3b FOXD3 LUN-1 POU2F1 POU2F1a Chx10 LHX3a/Lhx3a LyF-1 RSRFC4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SPHKAP promoter sequence

Search SABiosciences Chromatin IP Primers for SPHKAP

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPHKAP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q36 Ensembl cytogenetic band: 2q36.3 HGNC cytogenetic band: 2q36.3

SPHKAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPHKAP gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M228844: view genomic region (about GC identifiers)

Start:	228,844,666 bp from pter	End:	229,046,361 bp from pter
Size:	201,696 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SPKAP_HUMAN, Q2M3C7 (See protein sequence)

Recommended Name: A-kinase anchor protein SPHKAP

Size: 1700 amino acids; 186456 Da

Subunit: Interacts (via the PKA-RII subunit binding domain) with the RI subunit of PKA. Interacts with SPHK1; the

interaction greatly reduces SPHK1 activity

Subcellular location: Cytoplasm. Note=Colocalizes with SPHK1 in the cytoplasm

Sequence caution: Sequence=CAH18152.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: Q68DA3 Q68DR8 Q9C0I5

Alternative splicing: 2 isoforms: Q2M3C7-1 Q2M3C7-2

Explore the universe of human proteins at neXtProt for SPHKAP: NX_Q2M3C7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q2M3C7

SPHKAP Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001136116.1 NP_085126.2

ENSEMBL proteins:

ENSP00000375909 ENSP00000339886

Human Recombinant Protein Products:

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	Uscn Proteins for SPHKAP

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	--	--
GO:0005739	mitochondrion	IEA	--
GO:0030018	Z disc	IEA	--

SPHKAP for ontologies About GeneDecksing

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Assay Products for SPHKAP:

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	GenScript Custom Assay Services for SPHKAP
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	Uscn ELISAs and CLIAs for SPHKAP

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SPHKAP for domains About GeneDecksing

2 InterPro domains/families:

IPR018292 AKAP_110_C

IPR008382 SPHK1-interactor_AKAP_110

Graphical View of Domain Structure for InterPro Entry Q2M3C7

ProtoNet protein and cluster: Q2M3C7

UniProtKB/Swiss-Prot: SPKAP_HUMAN, Q2M3C7

Domain: RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions

with a complementary surface on the R-subunit dimer (By similarity)

Similarity: Belongs to the AKAP110 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SPKAP_HUMAN, Q2M3C7

Function: Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein

kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP

and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SPHKAP Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPHKAP
		8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate SPHKAP (see all 20):
		hsa-miR-30c hsa-miR-2052 hsa-miR-148b* hsa-miR-607 hsa-miR-4254 hsa-miR-4307 hsa-miR-30d hsa-miR-30a

		SwitchGear 3'UTR luciferase reporter plasmid: SPHKAP 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPHKAP (see all 4) OriGene shRNA RFP: SPHKAP OriGene siRNA: SPHKAP
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SPHKAP

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		GenScript: all cDNA clones in your preferred vector (see all 2): SPHKAP (NM_001142644)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPHKAP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPHKAP

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SPHKAP
		Search LifeMap BioReagents cell lines for SPHKAP

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPHKAP

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	12080051
GO:0051018	protein kinase A binding	IDA	--

SPHKAP for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SPHKAP

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for SPHKAP (Q2M3C7^{1, 3} ENSP00000375909⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SPHK1	Q9NYA1¹^,³, ENSP00000313681⁴	EBI-1803914,EBI-985303 I2D: score=2 STRING: ENSP00000313681

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SPHKAP

1 HMDB Compound for SPHKAP About this table

Compound	Synonyms	CAS #	PubMed Ids
Cyclic AMP	Cyclic AMP (see all 19)	60-92-4	--

Search CenterWatch for drugs/clinical trials and news about SPHKAP / SPKAP

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SPHKAP gene (2 alternative transcripts):

NM_001142644.1 NM_030623.3

Unigene Cluster for SPHKAP:

SPHK1 interactor, AKAP domain containing

Hs.436306 [show with all ESTs]

Unigene Representative Sequence: NM_001142644

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000392056(uc002vpq.2 uc002vpp.2 uc010zlx.1) ENST00000344657

ENST00000490603

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SPHKAP Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPHKAP
		8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate SPHKAP (see all 20):
		hsa-miR-30c hsa-miR-2052 hsa-miR-148b* hsa-miR-607 hsa-miR-4254 hsa-miR-4307 hsa-miR-30d hsa-miR-30a

		SwitchGear 3'UTR luciferase reporter plasmid: SPHKAP 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPHKAP (see all 4) OriGene shRNA RFP: SPHKAP OriGene siRNA: SPHKAP
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPHKAP

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPHKAP (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPHKAP (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): SPHKAP (NM_001142644)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPHKAP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPHKAP

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPHKAP Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SPHKAP
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPHKAP
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPHKAP

Additional cDNA sequence:

AB051465.1 AK090876.1 AK095042.1 AK125481.1 AK127071.1 BC104954.1 BC104956.1 BC143408.1

CR749297.1 CR749494.1

6 DOTS entries:

DT.110691 DT.100016439 DT.101960528 DT.432624 DT.65287977 DT.100655174

24/38 AceView cDNA sequences (see all 38):

AI290868 AK090876 AA907283 AB051465 Z41011 Z32823 AA910564 CR749297

AX746659 AL134539 AL601181 AK095042 AA461162 AW207414 AK127071 W61242

AA326580 BE670171 BE549786 BI912915 CR749494 Z45301 CB117706 AK125481

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SPHKAP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGATGAAGTT

About this image

SPHKAP expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Cerebral Cortex

Brain

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SPHKAP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPHKAP

SOURCE GeneReport for Unigene cluster: Hs.436306

UniProtKB/Swiss-Prot: SPKAP_HUMAN, Q2M3C7

Tissue specificity: Highly expressed in heart. Both isoforms abundantly expressed in ventricle. Also expressed in

spleen, ovary and brain

SABiosciences Custom PCR Arrays for SPHKAP

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPHKAP Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SPHKAP
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPHKAP
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPHKAP

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPHKAP

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for SPHKAP gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SPHKAP¹	SPHK1 interactor, AKAP domain containing	64.7(n) 57.2(a)		424789 NM_001177532.1 NP_001171003.1
lizard (Anolis carolinensis)	Reptilia	SPHKAP⁶	--	53(a)	1 ↔ 1	3(23234526-23252518)
zebrafish (Danio rerio)	Actinopterygii	sphkap¹	SPHK1 interactor, AKAP domain containing	53.23(n) 45.73(a)		100034387 NM_001083045.1 NP_001076514.1

ENSEMBL Gene Tree for SPHKAP (if available)
TreeFam Gene Tree for SPHKAP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SPHKAP gene

AKAP11²

SPHKAP for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs111801955^1,2	C,F,	--	228844177(+)	`ATGCCC/AGGTTT`	2	--	ds500¹		1		NA	120
rs77072825^1,2	F,	--	228844211(+)	`TAGGCG/AGCTGA`	2	--	ds500¹		1		WA	118
rs188330739^1,2		--	228844223(+)	`GGCACA/GTCCTC`	2	--	ds500¹		0	--	--	--	--
rs115984254^1,2	F,	--	228844251(+)	`GACTCA/GGGCCC`	2	--	ds500¹		1		WA	118
rs147154463^1,2		--	228844322(+)	`GGGGAC/TATTTG`	2	--	ds500¹		0	--	--	--	--
rs192216947^1,2		--	228844463(+)	`TGGTCA/CCAAAT`	2	--	ds500¹		0	--	--	--	--
rs183562096^1,2		--	228844633(+)	`TCTATA/GAGGTG`	2	--	ds500¹		0	--	--	--	--
rs200641860^1,2		--	228844911(+)	`GGCAT-/TTAG TTAAT`	2	--	ut3¹		0	--	--	--	--
rs115518414^1,2		--	228844942(+)	`ATAACC/ATAAAT`	2	--	ut3¹		1		WA	118
rs188291162^1,2		--	228845090(+)	`TCATGG/TTATGG`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SPHKAP (228844666 - 229046361 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for SPHKAP
4 CNVs: 32395 98159 2426 32396

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPHKAP

DNA2.0 Custom Variant and Variant Library Synthesis for SPHKAP

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SPHKAP for disorders           About GeneDecksing

OMIM gene information: 611646    OMIM disorders: --

2 diseases for SPHKAP:    About MalaCards

hyperglycemia hypoxia

Human Genome Epidemiology (HuGE) Navigator: SPHKAP (1 document)

Export disorders for SPHKAP gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SPHKAP gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with SPHKAP)

Utopia: connect your pdf to the dynamic
world of online information

Cloning and characterization of a protein kinase A anchoring protein (AKAP)-related protein that interacts with and regulates sphingosine kinase 1 activity. (PubMed id 12080051)^{1, 2, 3} Lacana E.... Spiegel S. (2002)
Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)^{1, 2, 3} Nagase T.... Ohara O. (2000)
Sphingosine kinase interacting protein is an A-kinase anchoring protein specific for type I cAMP-dependent protein kinase. (PubMed id 20394097)^{1, 2, 9} Kovanich D....Scholten A. (2010)
Genome wide analysis of acute myeloid leukemia reveal leukemia specific methylome and subtype specific hypomethylation of repeats. (PubMed id 22479372)¹ Saied M.H....Young B.D. (2012)
An entirely specific type I A-kinase anchoring protei n that can sequester two molecules of protein kinase A at mitochondria. (PubMed id 22084075)¹ Means C.K....Scott J.D. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Sphingosine kinase 1 is up-regulated during hypoxia in U87MG glioma cells. Role of hypoxia-inducible factors 1 and 2. (PubMed id 18055454)¹ Anelli V....Obeid L.M. (2008)
Activation of sphingosine kinase-1 mediates inhibition of vascular smooth muscle cell apoptosis by hyperglycemia. (PubMed id 17325258)¹ You B....Sun J. (2007)
Progesterone-induced sphingosine kinase-1 expression in the rat uterus during pregnancy and signaling consequences. (PubMed id 17164439)¹ Jeng Y.J....Soloff M.S. (2007)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 80309	HGNC: 30619	AceView: SKIP.1	Ensembl:ENSG00000153820	euGenes: HUgn80309
ECgene: SPHKAP	H-InvDB: SPHKAP

(According to HUGE)
About This Section

HUGE: KIAA1678

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SPHKAP	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SPHKAP gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SPHKAP gene:
Search GeneIP for patents involving SPHKAP

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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	Browse OriGene Antibodies		OriGene shRNA RFP for SPHKAP
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPHKAP		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPHKAP
	OriGene Protein Over-expression Lysate for SPHKAP		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for SPHKAP		OriGene 3'-UTR Clone for SPHKAP
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPHKAP		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPHKAP
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SPHKAP		OriGene Custom Protein Services for SPHKAP
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPHKAP
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPHKAP
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPHKAP
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPHKAP
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPHKAP
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPHKAP

	GenScript Custom Purified and Recombinant Proteins Services for SPHKAP		GenScript cDNA clones with any tag delivered in your preferred vector for SPHKAP
	GenScript Custom Assay Services for SPHKAP		GenScript Custom Superior Antibodies Services for SPHKAP
	GenScript Custom overexpressing Cell Line Services for SPHKAP		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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	Regulatory tfbs in SPHKAP promoter
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	Search for Antibodies for SPHKAP at Abcam
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SPHKAP Proteins, Antibodies, CLIAs, and ELISAs

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPHKAP

	SwitchGear 3'UTR luciferase reporter plasmids for SPHKAP
	SwitchGear Promoter luciferase reporter plasmids for SPHKAP

Search ThermoFisher Antibodies for SPHKAP

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPHKAP

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SPHKAP gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

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Export list of displayed genes

SPHKAP Gene

SPHK1 interactor, AKAP domain containing

Aliases
for SPHKAP gene

Summaries
for SPHKAP gene

Genomic Views
for SPHKAP gene

Proteins
for SPHKAP gene

Protein Domains /
Families
for SPHKAP gene

Function
for SPHKAP gene

Pathways & Interactions
for SPHKAP gene

Drugs & Compounds
for SPHKAP gene

Transcripts
for SPHKAP gene

Expression
for SPHKAP gene

Orthologs
for SPHKAP gene

Paralogs
for SPHKAP gene

Genomic Variants
for SPHKAP gene

Disorders / Diseases
for SPHKAP gene

Publications
for SPHKAP gene

External Searches for SPHKAP gene

Genome Databases showing SPHKAP gene

Other Databases showing SPHKAP gene

Specialized Databases showing SPHKAP gene

Intellectual Property
for SPHKAP gene

Products
for SPHKAP gene

View Random Gene

Advanced Search

Export list of displayed genes

SPHKAP Gene

SPHK1 interactor, AKAP domain containing

Aliasesfor SPHKAP gene

Summariesfor SPHKAP gene

Genomic Viewsfor SPHKAP gene

Proteinsfor SPHKAP gene

Protein Domains /Familiesfor SPHKAP gene

Functionfor SPHKAP gene

Pathways & Interactionsfor SPHKAP gene

Drugs & Compoundsfor SPHKAP gene

Transcriptsfor SPHKAP gene

Expression for SPHKAP gene

Orthologsfor SPHKAP gene

Paralogsfor SPHKAP gene

Genomic Variantsfor SPHKAP gene

Disorders / Diseasesfor SPHKAP gene

Publicationsfor SPHKAP gene

External Searches for SPHKAP gene

Genome Databases showing SPHKAP gene

Other Databases showing SPHKAP gene

Specialized Databases showing SPHKAP gene

Intellectual Propertyfor SPHKAP gene

Productsfor SPHKAP gene

View Random Gene

Aliases
for SPHKAP gene

Summaries
for SPHKAP gene

Genomic Views
for SPHKAP gene

Proteins
for SPHKAP gene

Protein Domains /
Families
for SPHKAP gene

Function
for SPHKAP gene

Pathways & Interactions
for SPHKAP gene

Drugs & Compounds
for SPHKAP gene

Transcripts
for SPHKAP gene

Expression
for SPHKAP gene

Orthologs
for SPHKAP gene

Paralogs
for SPHKAP gene

Genomic Variants
for SPHKAP gene

Disorders / Diseases
for SPHKAP gene

Publications
for SPHKAP gene

Intellectual Property
for SPHKAP gene

Products
for SPHKAP gene