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Aliases for SPHKAP Gene

Aliases for SPHKAP Gene

  • SPHK1 Interactor, AKAP Domain Containing 2 3
  • Sphingosine Kinase Type 1-Interacting Protein 2 3 4
  • SKIP 3 4 6
  • SPHK1-Interactor And AKAP Domain-Containing Protein 3 4
  • KIAA1678 4 6
  • SPHK1 (Sphingosine Kinase Type 1) Interacting Protein 3
  • A-Kinase Anchor Protein SPHKAP 3

External Ids for SPHKAP Gene

Summaries for SPHKAP Gene

GeneCards Summary for SPHKAP Gene

SPHKAP (SPHK1 Interactor, AKAP Domain Containing) is a Protein Coding gene. GO annotations related to this gene include protein kinase A binding. An important paralog of this gene is AKAP11.

UniProtKB/Swiss-Prot for SPHKAP Gene

  • Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPHKAP Gene

Genomics for SPHKAP Gene

Genomic Location for SPHKAP Gene

227,979,950 bp from pter
228,181,962 bp from pter
202,013 bases
Minus strand

Genomic View for SPHKAP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPHKAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPHKAP Gene

Regulatory Elements for SPHKAP Gene

Proteins for SPHKAP Gene

  • Protein details for SPHKAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    A-kinase anchor protein SPHKAP
    Protein Accession:
    Secondary Accessions:
    • Q68DA3
    • Q68DR8
    • Q9C0I5

    Protein attributes for SPHKAP Gene

    1700 amino acids
    Molecular mass:
    186456 Da
    Quaternary structure:
    • Interacts (via the PKA-RII subunit binding domain) with the RI subunit of PKA. Interacts with SPHK1; the interaction greatly reduces SPHK1 activity.
    • Sequence=CAH18152.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SPHKAP Gene


neXtProt entry for SPHKAP Gene

Proteomics data for SPHKAP Gene at MOPED

Post-translational modifications for SPHKAP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPHKAP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPHKAP Gene

Domains for SPHKAP Gene

Gene Families for SPHKAP Gene

  • AKAP :A-kinase anchor proteins

Protein Domains for SPHKAP Gene


  • RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.:
    • Q2M3C7
  • Belongs to the AKAP110 family.:
    • Q2M3C7
genes like me logo Genes that share domains with SPHKAP: view

Function for SPHKAP Gene

Molecular function for SPHKAP Gene

UniProtKB/Swiss-Prot Function: Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1.

Gene Ontology (GO) - Molecular Function for SPHKAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12080051
GO:0051018 protein kinase A binding IDA 20394097
genes like me logo Genes that share ontologies with SPHKAP: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SPHKAP Gene

Localization for SPHKAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPHKAP Gene

Cytoplasm. Note=Colocalizes with SPHK1 in the cytoplasm.

Subcellular locations from

Jensen Localization Image for SPHKAP Gene COMPARTMENTS Subcellular localization image for SPHKAP gene
Compartment Confidence
cytosol 3
nucleus 3
mitochondrion 2
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SPHKAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IBA --
GO:0030018 Z disc IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SPHKAP: view

Pathways for SPHKAP Gene

SuperPathways for SPHKAP Gene

No Data Available

Interacting Proteins for SPHKAP Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000375909 Q2M3C7-SPKAP_HUMAN for SPHKAP Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for SPHKAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010738 regulation of protein kinase A signaling IBA --
genes like me logo Genes that share ontologies with SPHKAP: view

No data available for Pathways by source for SPHKAP Gene

Compounds for SPHKAP Gene

(1) HMDB Compounds for SPHKAP Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP
genes like me logo Genes that share compounds with SPHKAP: view

Transcripts for SPHKAP Gene

Unigene Clusters for SPHKAP Gene

SPHK1 interactor, AKAP domain containing:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPHKAP Gene

No ASD Table

Relevant External Links for SPHKAP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPHKAP Gene

mRNA expression in normal human tissues for SPHKAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPHKAP Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (12.3), Brain - Cerebellum (9.7), Heart - Left Ventricle (7.9), and Brain - Hippocampus (5.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SPHKAP Gene

SOURCE GeneReport for Unigene cluster for SPHKAP Gene Hs.436306

mRNA Expression by UniProt/SwissProt for SPHKAP Gene

Tissue specificity: Highly expressed in heart. Both isoforms abundantly expressed in ventricle. Also expressed in spleen, ovary and brain.
genes like me logo Genes that share expressions with SPHKAP: view

Orthologs for SPHKAP Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPHKAP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPHKAP 36
  • 99.22 (n)
  • 98.71 (a)
  • 99 (a)
(Bos Taurus)
Mammalia SPHKAP 36
  • 82.32 (n)
  • 76.17 (a)
  • 75 (a)
(Canis familiaris)
Mammalia SPHKAP 36
  • 82.99 (n)
  • 77.36 (a)
  • 77 (a)
(Mus musculus)
Mammalia Sphkap 36
  • 78.59 (n)
  • 72.8 (a)
Sphkap 16
Sphkap 37
  • 72 (a)
(Monodelphis domestica)
Mammalia SPHKAP 37
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia SPHKAP 37
  • 45 (a)
(Rattus norvegicus)
Mammalia Sphkap 36
  • 78.56 (n)
  • 73.16 (a)
(Gallus gallus)
Aves SPHKAP 36
  • 64.94 (n)
  • 57.49 (a)
  • 50 (a)
(Anolis carolinensis)
Reptilia SPHKAP 37
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sphkap 36
  • 58.09 (n)
  • 49.45 (a)
(Danio rerio)
Actinopterygii sphkap 36
  • 55.66 (n)
  • 49.2 (a)
sphkap 37
  • 40 (a)
Species with no ortholog for SPHKAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPHKAP Gene

Gene Tree for SPHKAP (if available)
Gene Tree for SPHKAP (if available)

Paralogs for SPHKAP Gene

Paralogs for SPHKAP Gene

genes like me logo Genes that share paralogs with SPHKAP: view

Variants for SPHKAP Gene

Sequence variations from dbSNP and Humsavar for SPHKAP Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1011343 -- 227,982,053(-) AAAAA(A/T)ATTCA intron-variant
rs1011344 -- 227,982,047(-) ATTCA(C/G)TTGAT intron-variant
rs1343845 -- 227,992,443(+) TGATT(G/T)CTTGG intron-variant
rs2069255 -- 228,154,180(-) TGTCT(G/T)TCGTT intron-variant
rs2069256 -- 228,154,071(-) TAAAA(C/T)CTGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPHKAP Gene

Variant ID Type Subtype PubMed ID
nsv10221 CNV Loss 18304495
nsv875926 CNV Loss 21882294
nsv10222 CNV Loss 18304495
dgv1290e1 CNV Complex 17122850
nsv875927 CNV Loss 21882294
esv2678612 CNV Deletion 23128226
esv2721568 CNV Deletion 23290073
esv2721569 CNV Deletion 23290073
esv2721570 CNV Deletion 23290073
esv2529771 CNV Deletion 19546169

Relevant External Links for SPHKAP Gene

HapMap Linkage Disequilibrium report

Disorders for SPHKAP Gene

Relevant External Links for SPHKAP

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SPHKAP: view

No data available for UniProtKB/Swiss-Prot for SPHKAP Gene

Publications for SPHKAP Gene

  1. Sphingosine kinase interacting protein is an A-kinase anchoring protein specific for type I cAMP-dependent protein kinase. (PMID: 20394097) Kovanich D. … Scholten A. (ChemBioChem 2010) 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  3. Cloning and characterization of a protein kinase A anchoring protein (AKAP)-related protein that interacts with and regulates sphingosine kinase 1 activity. (PMID: 12080051) Lacana E. … Spiegel S. (J. Biol. Chem. 2002) 2 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  5. An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria. (PMID: 22084075) Means C.K. … Scott J.D. (Proc. Natl. Acad. Sci. U.S.A. 2011) 3

Products for SPHKAP Gene

  • antibodies-online peptides for SPHKAP
  • antibodies-online antibodies for SPHKAP
  • antibodies-online kits for SPHKAP

Sources for SPHKAP Gene

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