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SPHKAP Gene

protein-coding   GIFtS: 49
GCID: GC02M228844

SPHK1 Interactor, AKAP Domain Containing

  Search for SPHKAP
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SPHK1 Interactor, AKAP Domain Containing1 2     KIAA16783 5
Sphingosine Kinase Type 1-Interacting Protein1 2 3     A-Kinase Anchor Protein SPHKAP2
SKIP2 3 5     SPHK1 (Sphingosine Kinase Type 1) Interacting Protein2
SPHK1-Interactor And AKAP Domain-Containing Protein2 3     

External Ids:    HGNC: 306191   Entrez Gene: 803092   Ensembl: ENSG000001538207   OMIM: 6116465   UniProtKB: Q2M3C73   

Export aliases for SPHKAP gene to outside databases

Previous GC identifers: GC02M228553 GC02M220686


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SPHKAP Gene:
SPHKAP (SPHK1 interactor, AKAP domain containing) is a protein-coding gene. GO annotations related to this gene include protein kinase A binding. An important paralog of this gene is AKAP11.

UniProtKB/Swiss-Prot: SPKAP_HUMAN, Q2M3C7
Function: Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein
kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking
cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPHKAP gene promoter:
         AP-2rep   LHX3b/Lhx3b   FOXD3   LUN-1   POU2F1   POU2F1a   Chx10   LHX3a/Lhx3a   LyF-1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPHKAP promoter sequence
   Search Chromatin IP Primers for SPHKAP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPHKAP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q36   Ensembl cytogenetic band:  2q36.3   HGNC cytogenetic band: 2q36.3

SPHKAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPHKAP gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M228844:  view genomic region     (about GC identifiers)

Start:
228,844,666 bp from pter      End:
229,046,361 bp from pter
Size:
201,696 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SPKAP_HUMAN, Q2M3C7 (See protein sequence)
Recommended Name: A-kinase anchor protein SPHKAP  
Size: 1700 amino acids; 186456 Da
Subunit: Interacts (via the PKA-RII subunit binding domain) with the RI subunit of PKA. Interacts with SPHK1; the
interaction greatly reduces SPHK1 activity
Sequence caution: Sequence=CAH18152.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q68DA3 Q68DR8 Q9C0I5
Alternative splicing: 2 isoforms:  Q2M3C7-1   Q2M3C7-2   

Explore the universe of human proteins at neXtProt for SPHKAP: NX_Q2M3C7

Explore proteomics data for SPHKAP at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SPHKAP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001136116.1  NP_085126.2  

    ENSEMBL proteins: 
     ENSP00000375909   ENSP00000339886  

    SPHKAP Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
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    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for SPHKAP 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AKAP: A-kinase anchor proteins

    2 InterPro protein domains:
     IPR018292 AKAP_110_C
     IPR008382 SPHK1-interactor_AKAP_110

    Graphical View of Domain Structure for InterPro Entry Q2M3C7

    ProtoNet protein and cluster: Q2M3C7

    UniProtKB/Swiss-Prot: SPKAP_HUMAN, Q2M3C7
    Domain: RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein
    interactions with a complementary surface on the R-subunit dimer (By similarity)
    Similarity: Belongs to the AKAP110 family


    Find genes that share domains with SPHKAP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPKAP_HUMAN, Q2M3C7
    Function: Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein
    kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking
    cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12080051
    GO:0051018protein kinase A binding IDA--
         
    Find genes that share ontologies with SPHKAP           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPHKAP
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    miRNA
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    hsa-miR-30c hsa-miR-2052 hsa-miR-148b* hsa-miR-607 hsa-miR-4254 hsa-miR-4307 hsa-miR-30d hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidSPHKAP 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPKAP_HUMAN, Q2M3C7: Cytoplasm. Note=Colocalizes with SPHK1 in the cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3
    mitochondrion2
    cytoskeleton1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0030018Z disc IEA--

    Find genes that share ontologies with SPHKAP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPHKAP
    Interactions:

        Search GeneGlobe Interaction Network for SPHKAP

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SPHKAP (Q2M3C71, 3 ENSP000003759094) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SPHK1Q9NYA11, 3, ENSP000003136814EBI-1803914,EBI-985303 I2D: score=2 STRING: ENSP00000313681
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPHKAP (SPKAP)

    1 HMDB Compound for SPHKAP    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SPHKAP gene (2 alternative transcripts): 
    NM_001142644.1  NM_030623.3  

    Unigene Cluster for SPHKAP:

    SPHK1 interactor, AKAP domain containing
    Hs.436306  [show with all ESTs]
    Unigene Representative Sequence: NM_001142644
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392056(uc002vpq.2 uc002vpp.2 uc010zlx.1) ENST00000344657
    ENST00000490603
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SPHKAP (see all 20):
    hsa-miR-30c hsa-miR-2052 hsa-miR-148b* hsa-miR-607 hsa-miR-4254 hsa-miR-4307 hsa-miR-30d hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidSPHKAP 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat SPHKAP
      QuantiFast Probe-based Assays in human, mouse, rat SPHKAP

    Additional mRNA sequence: 

    AB051465.1 AK090876.1 AK095042.1 AK125481.1 AK127071.1 BC104954.1 BC104956.1 BC143408.1 
    CR749297.1 CR749494.1 

    6 DOTS entries:

    DT.110691  DT.100016439  DT.101960528  DT.432624  DT.65287977  DT.100655174 

    Selected AceView cDNA sequences (see all 38):

    AK090876 AX746659 AA907283 Z41011 AA910564 Z32823 CR749297 AI290868 
    AL134539 AB051465 AK095042 AL601181 AK127071 AA326580 BE670171 AA461162 
    BM805697 CB117706 AL601117 BE549786 Z45301 AK125481 W61242 AW207414 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SPHKAP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATGAAGTT
    SPHKAP Expression
    About this image


    SPHKAP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 4 entries
             Endocrine Progenitor Cells Ventral Pancreatic Bud
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Heart (Cardiovascular System)
     
     Lung (Respiratory System)
    SPHKAP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPHKAP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436306

    UniProtKB/Swiss-Prot: SPKAP_HUMAN, Q2M3C7
    Tissue specificity: Highly expressed in heart. Both isoforms abundantly expressed in ventricle. Also expressed in
    spleen, ovary and brain

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SPHKAP gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sphkap1 , 5 SPHK1 interactor, AKAP domain containing1, 5 78.59(n)1
    72.8(a)1
      1 (42.73 cM)5
    776291  NM_172430.31  NP_766018.31 
     832541395 
    chicken
    (Gallus gallus)
    Aves SPHKAP1 SPHK1 interactor, AKAP domain containing 64.94(n)
    57.49(a)
      424789  NM_001177532.2  NP_001171003.1 
    lizard
    (Anolis carolinensis)
    Reptilia SPHKAP6
    SPHK1 interactor, AKAP domain containing
    53(a)
    1 ↔ 1
    3(23168501-23256972)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sphkap1 SPHK1 interactor, AKAP domain containing 58.09(n)
    49.45(a)
      100490077  XM_002933367.2  XP_002933413.2 
    zebrafish
    (Danio rerio)
    Actinopterygii sphkap1 SPHK1 interactor, AKAP domain containing 55.66(n)
    49.2(a)
      100034387  NM_001083045.1  NP_001076514.1 


    ENSEMBL Gene Tree for SPHKAP (if available)
    TreeFam Gene Tree for SPHKAP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SPHKAP gene
    AKAP112  

    Find genes that share paralogs with SPHKAP           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SPHKAP (see all 4508)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs58392501,2
    C--220688549(+) GTGAA-/TT/TTT
            
    TTTTT
    2 -- int11CSA 2
    rs560314181,2
    C--220730853(+) TTTTT-/A/AA/ 
    TAA
    /TTTT
    AAATC
    4 -- int1 cds10--------
    rs752531781,2
    C--228335651(+) TTTTT-/GT/TG 
            
    TTTGT
    2 -- int10--------
    rs616000061,2
    C--228335652(+) TTTTT-/G/GT  
      
    /GTTTG
    TTGTT
    2 -- int11NA 2
    rs1118019551,2
    C,F--228844177(+) ATGCCC/AGGTTT 2 -- ds50011Minor allele frequency- A:0.02NA 120
    rs770728251,2
    C,F--228844211(+) TAGGCG/AGCTGA 2 -- ds50011Minor allele frequency- A:0.14WA 118
    rs1883307391,2
    --228844223(+) GGCACA/GTCCTC 2 -- ds50010--------
    rs1159842541,2
    C,F--228844251(+) GACTCA/GGGCCC 2 -- ds50011Minor allele frequency- G:0.06WA 118
    rs1471544631,2
    --228844322(+) GGGGAC/TATTTG 2 -- ds50010--------
    rs1922169471,2
    --228844463(+) TGGTCA/CCAAAT 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for SPHKAP (228844666 - 229046361 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for SPHKAP:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2721569CNV Deletion23290073
    esv2721568CNV Deletion23290073
    esv2529771CNV Deletion19546169
    esv2678612CNV Deletion23128226
    esv2721570CNV Deletion23290073
    nsv875926CNV Loss21882294
    nsv10222CNV Loss18304495
    nsv875927CNV Loss21882294
    nsv10221CNV Loss18304495
    dgv1290e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611646    OMIM disorders: --


    Find genes that share disorders with SPHKAP           About GenesLikeMe

    Genetic Association Database (GAD): SPHKAP
    Human Genome Epidemiology (HuGE) Navigator: SPHKAP (1 document)

    Export disorders for SPHKAP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SPHKAP gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with SPHKAP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a protein kinase A anchoring protein (AKAP)-related protein that interacts with and regulates sphingosine kinase 1 activity. (PubMed id 12080051)1, 2, 3 Lacana E.... Spiegel S. (J. Biol. Chem. 2002)
    2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    3. Sphingosine kinase interacting protein is an A-kinase anchoring protein specific for type I cAMP-dependent protein kinase. (PubMed id 20394097)1, 2, 9 Kovanich D....Scholten A. (ChemBioChem 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Genetic variants associated with disordered eating. (PubMed id 23568457)1 Wade T.D....Martin N.G. (Int J Eat Disord 2013)
    6. Genome wide analysis of acute myeloid leukemia reveal leukemia specific methylome and subtype specific hypomethylation of repeats. (PubMed id 22479372)1 Saied M.H....Young B.D. (PLoS ONE 2012)
    7. An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria. (PubMed id 22084075)1 Means C.K....Scott J.D. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    8. Sphingosine kinase 1 is up-regulated during hypoxia in U87MG glioma cells. Role of hypoxia-inducible factors 1 and 2. (PubMed id 18055454)1 Anelli V....Obeid L.M. (J. Biol. Chem. 2008)
    9. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    10. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80309 HGNC: 30619 AceView: SKIP.1 Ensembl:ENSG00000153820 euGenes: HUgn80309
    ECgene: SPHKAP H-InvDB: SPHKAP

    (According to HUGE)
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    HUGE: KIAA1678

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SPHKAP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SPHKAP gene:
    Search GeneIP for patents involving SPHKAP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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