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Aliases for SPHKAP Gene

Aliases for SPHKAP Gene

  • SPHK1 Interactor, AKAP Domain Containing 2 3 5
  • Sphingosine Kinase Type 1-Interacting Protein 2 3 4
  • SPHK1-Interactor And AKAP Domain-Containing Protein 3 4
  • SKIP 3 4
  • SPHK1 (Sphingosine Kinase Type 1) Interacting Protein 3
  • A-Kinase Anchor Protein SPHKAP 3
  • KIAA1678 4

External Ids for SPHKAP Gene

Previous GeneCards Identifiers for SPHKAP Gene

  • GC02M228553
  • GC02M228844
  • GC02M220686

Summaries for SPHKAP Gene

GeneCards Summary for SPHKAP Gene

SPHKAP (SPHK1 Interactor, AKAP Domain Containing) is a Protein Coding gene. GO annotations related to this gene include protein kinase A binding. An important paralog of this gene is AKAP11.

UniProtKB/Swiss-Prot for SPHKAP Gene

  • Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPHKAP Gene

Genomics for SPHKAP Gene

Regulatory Elements for SPHKAP Gene

Enhancers for SPHKAP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F228180 1.3 FANTOM5 Ensembl 11.3 +1.6 1594 0.7 RNF2 EZH2 SPHKAP GC02P228170
GH02F228687 0.2 ENCODE 8.4 -506.5 -506456 1.1 HLF CEBPB CEBPG ZNF644 RAD21 ATF4 ATF3 CEBPA HNF4G ZBTB33 SPHKAP ENSG00000228226 LOC105373920
GH02F228446 0.5 ENCODE 5.8 -265.1 -265077 1.7 RFX1 SMARCA4 POLR2A SPHKAP GC02P228505 LOC646794
GH02F228009 0.3 FANTOM5 3.6 +172.7 172703 0.2 SETDB1 SPHKAP C2orf83 GC02M228005 GC02P227989
GH02F228030 0.3 FANTOM5 1.4 +151.3 151336 0.2 SPHKAP GC02M228005 GC02P227989
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SPHKAP on UCSC Golden Path with GeneCards custom track

Genomic Location for SPHKAP Gene

Chromosome:
2
Start:
227,979,950 bp from pter
End:
228,181,962 bp from pter
Size:
202,013 bases
Orientation:
Minus strand

Genomic View for SPHKAP Gene

Genes around SPHKAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPHKAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPHKAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPHKAP Gene

Proteins for SPHKAP Gene

  • Protein details for SPHKAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2M3C7-SPKAP_HUMAN
    Recommended name:
    A-kinase anchor protein SPHKAP
    Protein Accession:
    Q2M3C7
    Secondary Accessions:
    • Q68DA3
    • Q68DR8
    • Q9C0I5

    Protein attributes for SPHKAP Gene

    Size:
    1700 amino acids
    Molecular mass:
    186456 Da
    Quaternary structure:
    • Interacts (via the PKA-RII subunit binding domain) with the RI subunit of PKA. Interacts with SPHK1; the interaction greatly reduces SPHK1 activity.
    SequenceCaution:
    • Sequence=CAH18152.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SPHKAP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPHKAP Gene

Post-translational modifications for SPHKAP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPHKAP Gene

No data available for DME Specific Peptides for SPHKAP Gene

Domains & Families for SPHKAP Gene

Gene Families for SPHKAP Gene

Protein Domains for SPHKAP Gene

Suggested Antigen Peptide Sequences for SPHKAP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2M3C7

UniProtKB/Swiss-Prot:

SPKAP_HUMAN :
  • RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
  • Belongs to the AKAP110 family.
Domain:
  • RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
Family:
  • Belongs to the AKAP110 family.
genes like me logo Genes that share domains with SPHKAP: view

Function for SPHKAP Gene

Molecular function for SPHKAP Gene

UniProtKB/Swiss-Prot Function:
Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1.

Gene Ontology (GO) - Molecular Function for SPHKAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12080051
GO:0051018 protein kinase A binding IDA 20394097
genes like me logo Genes that share ontologies with SPHKAP: view
genes like me logo Genes that share phenotypes with SPHKAP: view

Animal Model Products

miRNA for SPHKAP Gene

miRTarBase miRNAs that target SPHKAP

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPHKAP Gene

Localization for SPHKAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPHKAP Gene

Cytoplasm. Note=Colocalizes with SPHK1 in the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPHKAP Gene COMPARTMENTS Subcellular localization image for SPHKAP gene
Compartment Confidence
extracellular 5
cytosol 3
mitochondrion 3
nucleus 3

Gene Ontology (GO) - Cellular Components for SPHKAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IBA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SPHKAP: view

Pathways & Interactions for SPHKAP Gene

SuperPathways for SPHKAP Gene

No Data Available

Interacting Proteins for SPHKAP Gene

Gene Ontology (GO) - Biological Process for SPHKAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010738 regulation of protein kinase A signaling IBA --
genes like me logo Genes that share ontologies with SPHKAP: view

No data available for Pathways by source and SIGNOR curated interactions for SPHKAP Gene

Drugs & Compounds for SPHKAP Gene

(1) Drugs for SPHKAP Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
genes like me logo Genes that share compounds with SPHKAP: view

Transcripts for SPHKAP Gene

Unigene Clusters for SPHKAP Gene

SPHK1 interactor, AKAP domain containing:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPHKAP Gene

No ASD Table

Relevant External Links for SPHKAP Gene

GeneLoc Exon Structure for
SPHKAP
ECgene alternative splicing isoforms for
SPHKAP

Expression for SPHKAP Gene

mRNA expression in normal human tissues for SPHKAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPHKAP Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x12.3), Brain - Cerebellum (x9.7), Heart - Left Ventricle (x7.9), and Brain - Hippocampus (x5.6).

Protein differential expression in normal tissues from HIPED for SPHKAP Gene

This gene is overexpressed in Plasma (43.7), Heart (15.1), and Fetal heart (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPHKAP Gene



Protein tissue co-expression partners for SPHKAP Gene

NURSA nuclear receptor signaling pathways regulating expression of SPHKAP Gene:

SPHKAP

SOURCE GeneReport for Unigene cluster for SPHKAP Gene:

Hs.436306

mRNA Expression by UniProt/SwissProt for SPHKAP Gene:

Q2M3C7-SPKAP_HUMAN
Tissue specificity: Highly expressed in heart. Both isoforms abundantly expressed in ventricle. Also expressed in spleen, ovary and brain.
genes like me logo Genes that share expression patterns with SPHKAP: view

Primer Products

Orthologs for SPHKAP Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPHKAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPHKAP 34 35
  • 99.22 (n)
dog
(Canis familiaris)
Mammalia SPHKAP 34 35
  • 82.99 (n)
cow
(Bos Taurus)
Mammalia SPHKAP 34 35
  • 82.32 (n)
mouse
(Mus musculus)
Mammalia Sphkap 34 16 35
  • 78.59 (n)
rat
(Rattus norvegicus)
Mammalia Sphkap 34
  • 78.56 (n)
oppossum
(Monodelphis domestica)
Mammalia SPHKAP 35
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPHKAP 35
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPHKAP 34 35
  • 64.94 (n)
lizard
(Anolis carolinensis)
Reptilia SPHKAP 35
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sphkap 34
  • 58.09 (n)
zebrafish
(Danio rerio)
Actinopterygii sphkap 34 35
  • 55.66 (n)
Species where no ortholog for SPHKAP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPHKAP Gene

ENSEMBL:
Gene Tree for SPHKAP (if available)
TreeFam:
Gene Tree for SPHKAP (if available)

Paralogs for SPHKAP Gene

Paralogs for SPHKAP Gene

genes like me logo Genes that share paralogs with SPHKAP: view

Variants for SPHKAP Gene

Sequence variations from dbSNP and Humsavar for SPHKAP Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1011343 -- 227,982,053(-) AAAAA(A/T)ATTCA intron-variant
rs1011344 -- 227,982,047(-) ATTCA(C/G)TTGAT intron-variant
rs10164825 -- 228,031,025(+) ccaga(C/G)agtgg intron-variant
rs10167964 -- 228,122,065(+) GTACC(C/G)AAAGA intron-variant
rs10168194 -- 228,122,264(+) TATTT(C/G)AAGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPHKAP Gene

Variant ID Type Subtype PubMed ID
esv2529771 CNV deletion 19546169
esv2678612 CNV deletion 23128226
esv2721568 CNV deletion 23290073
esv2721569 CNV deletion 23290073
esv2721570 CNV deletion 23290073
esv2759116 CNV loss 17122850
esv3348593 CNV duplication 20981092
esv3594547 CNV loss 21293372
nsv10221 CNV loss 18304495
nsv10222 CNV loss 18304495
nsv1072078 CNV deletion 25765185
nsv1138897 CNV deletion 24896259
nsv1142363 CNV deletion 24896259
nsv1142368 CNV deletion 24896259

Variation tolerance for SPHKAP Gene

Residual Variation Intolerance Score: 21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.18; 80.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPHKAP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPHKAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPHKAP Gene

Disorders for SPHKAP Gene

Relevant External Links for SPHKAP

Genetic Association Database (GAD)
SPHKAP
Human Genome Epidemiology (HuGE) Navigator
SPHKAP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPHKAP

No disorders were found for SPHKAP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPHKAP Gene

Publications for SPHKAP Gene

  1. Sphingosine kinase interacting protein is an A-kinase anchoring protein specific for type I cAMP-dependent protein kinase. (PMID: 20394097) Kovanich D. … Scholten A. (ChemBioChem 2010) 3 4 22 64
  2. Cloning and characterization of a protein kinase A anchoring protein (AKAP)-related protein that interacts with and regulates sphingosine kinase 1 activity. (PMID: 12080051) Lacana E. … Spiegel S. (J. Biol. Chem. 2002) 2 3 4 64
  3. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd B.J. … Pagliarini D.J. (Mol. Cell 2016) 3 64

Products for SPHKAP Gene

Sources for SPHKAP Gene

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