Aliases for SPHK2 Gene
External Ids for SPHK2 Gene
Previous GeneCards Identifiers for SPHK2 Gene
This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
GeneCards Summary for SPHK2 Gene
SPHK2 (Sphingosine Kinase 2) is a Protein Coding gene. Diseases associated with SPHK2 include breast cancer. Among its related pathways are Sphingolipid metabolism and Sphingolipid metabolism. GO annotations related to this gene include NAD+ kinase activity and Ras GTPase binding. An important paralog of this gene is AGK.
UniProtKB/Swiss-Prot for SPHK2 Gene
Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides.
Sphingosine kinase (SphK) mediates the conversion of sphingosine to sphingosine-1-phosphate, a key sphingolipid signaling molecule involved in cell growth, survival, differentiation and motility. SphK constitutes an important checkpoint in the regulation of circulating levels of ceramide, sphingosine and sphingosine-1-phosphate. Two mammalian isoforms have been cloned - SPHK1 and SPHK2