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Aliases for SPHK2 Gene

Aliases for SPHK2 Gene

  • Sphingosine Kinase 2 2 3
  • SPK 2 3 4
  • SK 2 3 4
  • Sphingosine Kinase Type 2 3
  • EC 2.7.1.91 4
  • SPK-2 3
  • SK-2 3

External Ids for SPHK2 Gene

Summaries for SPHK2 Gene

Entrez Gene Summary for SPHK2 Gene

  • This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for SPHK2 Gene

SPHK2 (Sphingosine Kinase 2) is a Protein Coding gene. Diseases associated with SPHK2 include breast cancer. Among its related pathways are Sphingolipid metabolism and Sphingolipid metabolism. GO annotations related to this gene include NAD+ kinase activity and Ras GTPase binding. An important paralog of this gene is AGK.

UniProtKB/Swiss-Prot for SPHK2 Gene

  • Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides.

Tocris Summary for SPHK2 Gene

  • Sphingosine kinase (SphK) mediates the conversion of sphingosine to sphingosine-1-phosphate, a key sphingolipid signaling molecule involved in cell growth, survival, differentiation and motility. SphK constitutes an important checkpoint in the regulation of circulating levels of ceramide, sphingosine and sphingosine-1-phosphate. Two mammalian isoforms have been cloned - SPHK1 and SPHK2.

Gene Wiki entry for SPHK2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPHK2 Gene

Genomics for SPHK2 Gene

Genomic Location for SPHK2 Gene

Start:
48,619,291 bp from pter
End:
48,630,717 bp from pter
Size:
11,427 bases
Orientation:
Plus strand

Genomic View for SPHK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPHK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPHK2 Gene

Regulatory Elements for SPHK2 Gene

Proteins for SPHK2 Gene

  • Protein details for SPHK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRA0-SPHK2_HUMAN
    Recommended name:
    Sphingosine kinase 2
    Protein Accession:
    Q9NRA0
    Secondary Accessions:
    • A0T4C8
    • B4DU87
    • Q9BRN1
    • Q9H0Q2
    • Q9NWU7

    Protein attributes for SPHK2 Gene

    Size:
    654 amino acids
    Molecular mass:
    69217 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPHK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPHK2 Gene

Proteomics data for SPHK2 Gene at MOPED

Post-translational modifications for SPHK2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SPHK2 Gene

Domains for SPHK2 Gene

Gene Families for SPHK2 Gene

Protein Domains for SPHK2 Gene

UniProtKB/Swiss-Prot:

SPHK2_HUMAN
Domain:
  • Contains 1 DAGKc domain.:
    • Q9NRA0
genes like me logo Genes that share domains with SPHK2: view

Function for SPHK2 Gene

Molecular function for SPHK2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=3.4 uM for sphingosine {ECO:0000269 PubMed:10751414}; pH dependence: Optimum pH is 7.5. {ECO:0000269 PubMed:10751414};
UniProtKB/Swiss-Prot CatalyticActivity: ATP + sphinganine = ADP + sphinganine 1-phosphate.
UniProtKB/Swiss-Prot CatalyticActivity: ATP + sphingosine = ADP + sphingosine 1-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by sulfatide.
UniProtKB/Swiss-Prot Function: Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides.

Enzyme Numbers (IUBMB) for SPHK2 Gene

Gene Ontology (GO) - Molecular Function for SPHK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003951 NAD+ kinase activity IEA --
GO:0004143 diacylglycerol kinase activity IEA --
GO:0005515 protein binding IPI 11777919
GO:0005524 ATP binding IEA --
GO:0008481 sphinganine kinase activity NAS 10751414
genes like me logo Genes that share ontologies with SPHK2: view
genes like me logo Genes that share phenotypes with SPHK2: view

Animal Models for SPHK2 Gene

MGI Knock Outs for SPHK2:

miRNA for SPHK2 Gene

miRTarBase miRNAs that target SPHK2

No data available for Transcription Factor Targeting and HOMER Transcription for SPHK2 Gene

Localization for SPHK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPHK2 Gene

Isoform 1: Cytoplasm. Membrane.
Isoform 2: Lysosome membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPHK2 Gene COMPARTMENTS Subcellular localization image for SPHK2 gene
Compartment Confidence
cytosol 5
lysosome 5
vacuole 5
nucleus 3
endoplasmic reticulum 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SPHK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 17897319
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 10751414
genes like me logo Genes that share ontologies with SPHK2: view

Pathways for SPHK2 Gene

genes like me logo Genes that share pathways with SPHK2: view

Gene Ontology (GO) - Biological Process for SPHK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001568 blood vessel development IEA --
GO:0003376 sphingosine-1-phosphate signaling pathway IMP 23106337
GO:0006665 sphingolipid metabolic process TAS --
GO:0006669 sphinganine-1-phosphate biosynthetic process NAS 10751414
GO:0006670 sphingosine metabolic process --
genes like me logo Genes that share ontologies with SPHK2: view

Compounds for SPHK2 Gene

(2) Tocris Compounds for SPHK2 Gene

Compound Action Cas Number
N,N-Dimethylsphingosine Sphingosine kinase inhibitor [119567-63-4]
SK1-I Sphingosine kinase 1 (SphK1) inhibitor; antiproliferative [1072443-89-0]

(7) HMDB Compounds for SPHK2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4
Sphinganine
  • 2-amino-D-erythro-1,3-Octadecanediol
764-22-7
Sphinganine 1-phosphate
  • 2-amino-3-hydroxyoctadecyl dihydrogen phosphate
19794-97-9

(2) Novoseek inferred chemical compound relationships for SPHK2 Gene

Compound -log(P) Hits PubMed IDs
sphingosine 94.2 48
ceramide 72 6
genes like me logo Genes that share compounds with SPHK2: view

Transcripts for SPHK2 Gene

mRNA/cDNA for SPHK2 Gene

Unigene Clusters for SPHK2 Gene

Sphingosine kinase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPHK2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b · 13c ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: -
SP4: - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - - -
SP8:
SP9:
SP10: - - - - - - - - - - - - - - - -
SP11: - - - - - - - -
SP12: - - - -
SP13:
SP14: - - - - - - -
SP15: - - - - - - - -
SP16: - - - - - - - -
SP17: - - - - - -
SP18: - - -
SP19: - -
SP20: - - -

ExUns: 14 ^ 15a · 15b · 15c · 15d ^ 16a · 16b ^ 17a · 17b ^ 18
SP1: -
SP2: -
SP3: -
SP4:
SP5: -
SP6: -
SP7:
SP8: -
SP9: - - -
SP10:
SP11:
SP12:
SP13: - - -
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

Relevant External Links for SPHK2 Gene

GeneLoc Exon Structure for
SPHK2
ECgene alternative splicing isoforms for
SPHK2

Expression for SPHK2 Gene

mRNA expression in normal human tissues for SPHK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPHK2 Gene

SOURCE GeneReport for Unigene cluster for SPHK2 Gene Hs.528006

genes like me logo Genes that share expressions with SPHK2: view

Orthologs for SPHK2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SPHK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPHK2 36
  • 97.49 (n)
  • 96.64 (a)
SPHK2 37
  • 81 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPHK2 36
  • 85.58 (n)
  • 88.14 (a)
SPHK2 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPHK2 36
  • 87.77 (n)
  • 90.83 (a)
SPHK2 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sphk2 36
  • 80.92 (n)
  • 84.03 (a)
Sphk2 16
Sphk2 37
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPHK2 37
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sphk2 36
  • 80.67 (n)
  • 84.67 (a)
lizard
(Anolis carolinensis)
Reptilia SPHK2 37
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sphk2 36
  • 57.41 (n)
  • 57.35 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.12967 36
sphk2 36
  • 58.51 (n)
  • 61.2 (a)
sphk2 37
  • 38 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Sk1 36
  • 49.18 (n)
  • 41.63 (a)
Sk1 37
  • 28 (a)
ManyToMany
Sk2 37
  • 29 (a)
ManyToMany
Sk1 38
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea sphk-1 36
  • 40.16 (n)
  • 32.08 (a)
sphk-1 37
  • 24 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LCB4 37
  • 19 (a)
ManyToMany
LCB5 37
  • 18 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 32 (a)
OneToMany
Species with no ortholog for SPHK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPHK2 Gene

ENSEMBL:
Gene Tree for SPHK2 (if available)
TreeFam:
Gene Tree for SPHK2 (if available)

Paralogs for SPHK2 Gene

Paralogs for SPHK2 Gene

Selected SIMAP similar genes for SPHK2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SPHK2: view

Variants for SPHK2 Gene

Sequence variations from dbSNP and Humsavar for SPHK2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs281410 -- 48,626,588(+) ggcgg(G/T)tggat intron-variant
rs281411 -- 48,626,602(+) ctgag(A/G)tcagg intron-variant
rs386243 -- 48,624,233(+) CCCAG(C/T)TCTCG intron-variant, upstream-variant-2KB
rs510066 -- 48,623,330(+) ccgcc(G/T)cggcc intron-variant, upstream-variant-2KB
rs561395 -- 48,622,051(+) GAGAT(C/T)GAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPHK2 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
dgv3966n71 CNV Loss 21882294
nsv912225 CNV Loss 21882294
dgv3967n71 CNV Loss 21882294
esv1003432 CNV Gain 20482838

Relevant External Links for SPHK2 Gene

HapMap Linkage Disequilibrium report
SPHK2

Disorders for SPHK2 Gene

(1) MalaCards Diseases for SPHK2 Gene

Search for SPHK2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for SPHK2 Gene

(1) Novoseek inferred disease relationships for SPHK2 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 19.1 3

Relevant External Links for SPHK2

Human Genome Epidemiology (HuGE) Navigator
SPHK2
genes like me logo Genes that share disorders with SPHK2: view

No data available for UniProtKB/Swiss-Prot for SPHK2 Gene

Publications for SPHK2 Gene

  1. Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform. (PMID: 10751414) Liu H. … Spiegel S. (J. Biol. Chem. 2000) 2 3 4 23
  2. A lipid binding domain in sphingosine kinase 2. (PMID: 19168031) Don A.S. … Rosen H. (Biochem. Biophys. Res. Commun. 2009) 3 4 23
  3. Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and Akt activation. (PMID: 19240026) Nemoto S. … Banno Y. (J. Biol. Chem. 2009) 3 23
  4. Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells. (PMID: 20197547) Weigert A. … BrA1ne B. (Blood 2010) 3 23
  5. Expression of sphingosine kinase 2 in synovial fibroblasts of rheumatoid arthritis contributing to apoptosis by a sphingosine analogue, FTY720. (PMID: 19490468) Kamada K. … Nose M. (Pathol. Int. 2009) 3 23

Products for SPHK2 Gene

  • Addgene plasmids for SPHK2

Sources for SPHK2 Gene

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