Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPHK1 Gene

protein-coding   GIFtS: 68
GCID: GC17P074380

Sphingosine Kinase 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sphingosine Kinase 11 2
SPHK2 3
SK 12 3
SPK 12 3
EC 2.7.1.913
SPK3

External Ids:    HGNC: 112401   Entrez Gene: 88772   Ensembl: ENSG000001761707   OMIM: 6037305   UniProtKB: Q9NYA13   

Export aliases for SPHK1 gene to outside databases

Previous GC identifers: GC17U990140 GC17P077371 GC17P074843 GC17P074977 GC17P071890 GC17P069809


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SPHK1 Gene:
The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate
(S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates
proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors.
This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway
important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Sep 2011)

GeneCards Summary for SPHK1 Gene: 
SPHK1 (sphingosine kinase 1) is a protein-coding gene. Diseases associated with SPHK1 include hereditary neuralgic amyotrophy, and large granular lymphocyte leukemia, and among its related super-pathways are Sphingolipid metabolism and Metabolic pathways. GO annotations related to this gene include magnesium ion binding and protein phosphatase 2A binding. An important paralog of this gene is CERKL.

UniProtKB/Swiss-Prot: SPHK1_HUMAN, Q9NYA1
Function: Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator
with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent
sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol,
ceramide, or phosphatidylinositol

summary for SPHK1 Gene:
Sphingosine kinase (SphK) mediates the conversion of sphingosine to sphingosine-1-phosphate, a key
sphingolipid signaling molecule involved in cell growth, survival, differentiation and motility. SphK
constitutes an important checkpoint in the regulation of circulating levels of ceramide, sphingosine and
sphingosine-1-phosphate. Two mammalian isoforms have been cloned - SPHK1 and SPHK2.

Gene Wiki entry for SPHK1 (Sphingosine kinase 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPHK1 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): SPHK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SPHK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPHK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.2   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.2

SPHK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPHK1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P074380:  view genomic region     (about GC identifiers)

Start:
74,372,665 bp from pter      End:
74,383,941 bp from pter
Size:
11,277 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SPHK1_HUMAN, Q9NYA1 (See protein sequence)
Recommended Name: Sphingosine kinase 1  
Size: 384 amino acids; 42518 Da
Cofactor: Magnesium
Subunit: Interacts with ACY1 (By similarity). Binds to calmodulin. Interacts with SPHKAP
Subcellular location: Cytoplasm. Nucleus
Miscellaneous: Sphingosine 1-phosphate stimulates TRAF2 E3 ubiquitin ligase activity, and promotes activation of
NF-kappa-B in response to TNF signaling
3 PDB 3D structures from and Proteopedia for SPHK1:
3VZB (3D)        3VZC (3D)        3VZD (3D)    
Secondary accessions: Q8N632 Q96GK1 Q9HD92 Q9NY70 Q9NYL3
Alternative splicing: 3 isoforms:  Q9NYA1-1   Q9NYA1-2   Q9NYA1-3   (Variant in position: 34:A->T (in dbSNP:rs346803))

Explore the universe of human proteins at neXtProt for SPHK1: NX_Q9NYA1

Explore proteomics data for SPHK1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NYA1

  • SPHK1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SPHK1 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001136073.1  NP_001136074.1  NP_068807.2  NP_892010.2  

    ENSEMBL proteins: 
     ENSP00000468474   ENSP00000440970   ENSP00000466422   ENSP00000465002   ENSP00000465726  
     ENSP00000468547   ENSP00000313681   ENSP00000376285  
    Reactome Protein details: Q9NYA1
    Human Recombinant Protein Products for SPHK1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for SPHK1 (Sphingosine Kinase 1/SPHK1)
    Enzo Life Sciences proteins for SPHK1
    OriGene Purified Protein for SPHK1
    OriGene Protein Over-expression Lysate for SPHK1
    OriGene MassSpec for SPHK1 
    OriGene Custom Protein Services for SPHK1
    GenScript Custom Purified and Recombinant Proteins Services for SPHK1
    Novus Biologicals SPHK1 Proteins
    Novus Biologicals SPHK1 Lysates
    Sino Biological Recombinant Protein for SPHK1
    Sino Biological Cell Lysate for SPHK1 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SPHK1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA15623571
    GO:0005829cytosol TAS10863092
    GO:0005886plasma membrane IDA--

    SPHK1 for ontologies           About GeneDecksing



    SPHK1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for SPHK1 (Sphingosine Kinase 1/SPHK1)
    Cell Signaling Technology (CST) Antibodies for SPHK1 
    OriGene Antibodies for SPHK1
    OriGene Custom Antibody Services for SPHK1
    GenScript Custom Superior Antibodies Services for SPHK1
    Novus Biologicals SPHK1 Antibodies
    Abcam antibodies for SPHK1
    Cloud-Clone Corp. Antibodies for SPHK1 
    ThermoFisher Antibody for SPHK1
    LSBio Antibodies in human, mouse, rat for SPHK1 

    Assay Products for SPHK1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SPHK1
    R&D Systems ELISAs for SPHK1 (Sphingosine Kinase 1/SPHK1)
    GenScript Custom Assay Services for SPHK1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SPHK1 
    Cloud-Clone Corp. CLIAs for SPHK1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: sphingosine kinase 1 
    Sphingosine kinase family

    1 InterPro protein domain:
     IPR001206 Diacylglycerol_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9NYA1

    ProtoNet protein and cluster: Q9NYA1

    UniProtKB/Swiss-Prot: SPHK1_HUMAN, Q9NYA1
    Similarity: Contains 1 DAGKc domain


    SPHK1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPHK1_HUMAN, Q9NYA1
    Function: Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator
    with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent
    sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol,
    ceramide, or phosphatidylinositol
    Catalytic activity: ATP + sphinganine = ADP + sphinganine 1-phosphate
    Catalytic activity: ATP + sphingosine = ADP + sphingosine 1-phosphate
    Biophysicochemical properties: Kinetic parameters: KM=14 uM for sphingosine; KM=20 uM for dihydrosphingosine;
    KM=77 uM for ATP; pH dependence: Optimum pH is 7.4;

         Enzyme Number (IUBMB): EC 2.7.1.911

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding ISS--
    GO:0003677DNA binding IDA12393916
    GO:0003951NAD+ kinase activity IEA--
    GO:0004143diacylglycerol kinase activity IEA--
    GO:0005515protein binding IPI12080051
         
    SPHK1 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for SPHK1:
     Decreased CYP1A1 activity afte  Decreased number of cells in m  Increased HPV18 LCR reporter a  Increased apoptosis 
     Synthetic lethal with Ras 

         10 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Sphk1):
     cardiovascular system  cellular  embryogenesis  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  muscle  nervous system  normal 

    SPHK1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SPHK1: Sphk1tm1Rlp Sphk1tm1Npa Sphk1tm1.1Cgh

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SPHK1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SPHK1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPHK1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPHK1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPHK1
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate SPHK1:
    hsa-miR-124 hsa-miR-3176 hsa-miR-506 hsa-miR-3922-3p
    SwitchGear 3'UTR luciferase reporter plasmidSPHK1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SPHK1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPHK1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SPHK1
    Sirion Biotech Customized adenovirus for overexpression of SPHK1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SPHK1 (see all 24)
    OriGene ORF clones in mouse, rat for SPHK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): SPHK1 (NM_182965)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPHK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPHK1
    Sirion Biotech Customized lentivirus for stable overexpression of SPHK1 
                         Customized lentivirus expression plasmids for stable overexpression of SPHK1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SPHK1
    Search LifeMap BioReagents cell lines for SPHK1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPHK1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SPHK1 About   (see all 18)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Sphingolipid metabolism
    Sphingolipid metabolism0.63
    Sphingolipid de novo biosynthesis0.47
    Sphingolipid metabolism0.63
    Sphingolipid Metabolism0.42
    2Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40
    3Development VEGF signaling via VEGFR2 - generic cascades
    Development VEGF signaling via VEGFR2 - generic cascades0.75
    VEGF - VEGF R2 Signaling Pathways 0.39
    Development VEGF signaling and activation0.75
    4Immune response Fc epsilon RI pathway
    VEGF signaling pathway0.39
    Fc-epsilon receptor I signaling in mast cells0.33
    5Chaperonin-mediated protein folding
    Chaperonin-mediated protein folding0.91
    Association of TriC/CCT with target proteins during biosynthesis0.60
    Protein folding0.91

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for SPHK1
        Development VEGF signaling and activation
    Development VEGF signaling via VEGFR2 - generic cascades

    1 R&D Systems Pathway for SPHK1
        VEGF - VEGF R2 Signaling Pathways

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SPHK1
        Ceramide Pathway
    S-1P Stimulated Signaling
    TNF-Induced Apoptosis Implicating Sphingolipids
    Human Embryonic Stem Cell Pluripotency
    VEGF and S-1P Signaling

    1 Cell Signaling Technology (CST) Pathway for SPHK1
        Ca, cAMP and Lipid Signaling

    2 GeneGo (Thomson Reuters) Pathways for SPHK1
        Development VEGF signaling via VEGFR2 - generic cascades
    Development VEGF signaling and activation

    5/7 BioSystems Pathways for SPHK1 (see all 7)
        Signal Transduction of S1P Receptor
    Sphingolipid Metabolism
    sphingosine and sphingosine-1-phosphate metabolism
    Fc-epsilon receptor I signaling in mast cells
    PDGFR-beta signaling pathway


    5/8        Reactome Pathways for SPHK1 (see all 8)
        Association of TriC/CCT with target proteins during biosynthesis
    Chaperonin-mediated protein folding
    Sphingolipid metabolism
    Metabolism
    Protein folding


    5/6         Kegg Pathways  (Kegg details for SPHK1) (see all 6):
        Sphingolipid metabolism
    Metabolic pathways
    Calcium signaling pathway
    VEGF signaling pathway
    Fc gamma R-mediated phagocytosis


    SPHK1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SPHK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/51 Interacting proteins for SPHK1 (Q9NYA11, 2, 3 ENSP000003136814) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTSBP078582, 3, ENSP000003420704MINT-3974266 MINT-3974278 MINT-3974294 MINT-3974318 I2D: score=2 STRING: ENSP00000342070
    TRAF6Q9Y4K32, 3MINT-4050292 MINT-4050310 I2D: score=2 
    EEF1A1P681041, 3, ENSP000003300544EBI-985303,EBI-352162 I2D: score=1 STRING: ENSP00000330054
    FHL2Q141921, 3, ENSP000003229094EBI-985303,EBI-701903 I2D: score=3 STRING: ENSP00000322909
    SPHKAPQ2M3C71, 3, ENSP000003759094EBI-985303,EBI-1803914 I2D: score=2 STRING: ENSP00000375909
    About this table

    Gene Ontology (GO): 5/28 biological process terms (GO ID links to tree view) (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001568blood vessel development IEA--
    GO:0006457protein folding TAS--
    GO:0006665sphingolipid metabolic process TAS--
    GO:0006670sphingosine metabolic process IDA--
    GO:0006954inflammatory response IEA--

    SPHK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SPHK1 for compounds           About GeneDecksing

    EMD Millipore small molecules for SPHK1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for SPHK1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    N,N-Dimethylsphingosine Sphingosine kinase inhibitor[119567-63-4]
    SK1-ISphingosine kinase 1 (SphK1) inhibitor; antiproliferative[1072443-89-0]

    10/42 HMDB Compounds for SPHK1 (see all 42)    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Cer(d18:0/12:0) ----
    Cer(d18:0/14:0) ----
    Cer(d18:0/16:0) ----
    Cer(d18:0/18:0) ----
    Cer(d18:0/18:1(11Z)) ----
    Cer(d18:0/18:1(9Z)) ----
    Cer(d18:0/20:0) ----
    Cer(d18:0/22:0) ----

    10/25 Novoseek inferred chemical compound relationships for SPHK1 gene (see all 25)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sphingosine 97.7 499 16281067 (6), 18620522 (6), 17643421 (6), 14532121 (4) (see all 99)
    n,n-dimethylsphingosine 93.7 32 15302883 (2), 11418646 (2), 15848761 (1), 15265705 (1) (see all 14)
    ceramide 83.9 68 16357178 (5), 16281067 (4), 19240026 (4), 19765607 (3) (see all 22)
    sphinganine 1-phosphate 80.4 5 18644793 (1), 16278291 (1), 16529909 (1)
    ceramides 55.1 1 18283525 (1)
    lipid 50.8 35 19782042 (2), 18638570 (1), 12954646 (1), 15265705 (1) (see all 20)
    phosphatidylserine 35.9 4 10751414 (1), 19782042 (1)
    camptothecin 32.8 7 16357178 (3), 16516161 (3)
    phosphatidylinositol 31.4 2 19325137 (1), 11418646 (1)
    phorbol 28.5 1 20236935 (1)

    Search CenterWatch for drugs/clinical trials and news about SPHK1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SPHK1 gene (4 alternative transcripts): 
    NM_001142601.1  NM_001142602.1  NM_021972.3  NM_182965.2  

    Unigene Cluster for SPHK1:

    Sphingosine kinase 1
    Hs.68061  [show with all ESTs]
    Unigene Representative Sequence: AK095578
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000591651 ENST00000545180(uc002jrf.1) ENST00000588682 ENST00000591762
    ENST00000590379 ENST00000592299 ENST00000590959 ENST00000323374(uc002jrh.2 uc002jrj.2 uc002jri.2)
    ENST00000392496(uc002jrg.1 uc002jrk.3) ENST00000587167
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPHK1
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate SPHK1:
    hsa-miR-124 hsa-miR-3176 hsa-miR-506 hsa-miR-3922-3p
    SwitchGear 3'UTR luciferase reporter plasmidSPHK1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SPHK1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPHK1
    Clone
    Products:
         
    OriGene clones in human, mouse for SPHK1 (see all 24)
    OriGene ORF clones in mouse, rat for SPHK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): SPHK1 (NM_182965)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPHK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPHK1
    Sirion Biotech Customized lentivirus for stable overexpression of SPHK1 
                         Customized lentivirus expression plasmids for stable overexpression of SPHK1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SPHK1
    OriGene qSTAR qPCR primer pairs in human, mouse for SPHK1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPHK1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPHK1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPHK1

    Additional mRNA sequence: 

    AF200328.1 AF238083.1 AF266756.1 AJ245504.1 AK022402.1 AK023393.1 AK095578.1 AK122781.1 
    AK225250.1 AK225258.1 AK292294.1 AK292614.1 BC004112.2 BC008040.2 BC009419.1 BC014439.1 
    BC030553.1 

    12 DOTS entries:

    DT.97787241  DT.121009204  DT.100818135  DT.100818143  DT.100036081  DT.100818141  DT.121009321  DT.95274954 
    DT.100722931  DT.100818142  DT.100698066  DT.91708490 

    24/113 AceView cDNA sequences (see all 113):

    BU626812 BU630558 AI074186 AK022402 NM_182965 CD366097 BM916526 AI042283 
    BM810136 AA026251 BQ027486 CD369198 CA307119 BX106465 BU728196 BM709951 
    BC004112 BM471470 BC030553 BQ109456 NM_021972 BP364701 BX363408 BM832647 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for SPHK1 (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b
    SP1:        -     -     -     -     -     -     -     -     -           -     -                                               -               
    SP2:                                                  -     -           -     -                                               -               
    SP3:                                                  -     -           -                                                     -               
    SP4:                                                        -           -     -                                               -               
    SP5:              -     -     -     -     -     -     -     -           -     -                                                               


    ECgene alternative splicing isoforms for SPHK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPHK1 expression in normal human tissues (normalized intensities)      SPHK1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAAGGGCA
    SPHK1 Expression
    About this image


    SPHK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Proerythroblasts Hematopoietic Bone Marrow
             blood outgrowth endothelial cell   
     
     Uncategorized (Uncategorized)    fully expand to see all 2 entries
             PureStem progenitor F15
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             huvec   
     
     Smooth Muscle (Muscoskeletal System)
             Mural Cells Splanchnic Mesoderm
     
     Peripheral Nervous System (Nervous System)
             Human Perineurial Cells (HPC)   

    See SPHK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPHK1

    SOURCE GeneReport for Unigene cluster: Hs.68061

    UniProtKB/Swiss-Prot: SPHK1_HUMAN, Q9NYA1
    Tissue specificity: Widely expressed with highest levels in adult liver, kidney, heart and skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Arrays including SPHK1: 
              Hypertension in human mouse rat
              Endothelial Cell Biology in human mouse rat
              VEGF Signaling in human mouse rat
              Apoptosis 384HT in human mouse rat
              Angiogenesis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SPHK1
    OriGene qSTAR qPCR primer pairs in human, mouse for SPHK1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPHK1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPHK1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPHK1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPHK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SPHK1 gene from 10/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sphk11 , 5 sphingosine kinase 11, 5 79.93(n)1
    81.15(a)1
      11 (81.42 cM)5
    206981  NM_001172472.11  NP_001165943.11 
     1165309255 
    chicken
    (Gallus gallus)
    Aves SPHK11 sphingosine kinase 1 65.53(n)
    59.09(a)
      427803  XM_425374.3  XP_425374.3 
    lizard
    (Anolis carolinensis)
    Reptilia SPHK16
    sphingosine kinase 1
    38(a)
    1 ↔ 1
    2(112293474-112338472)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX706001.12   -- 74.9(n)    BX706001.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003318401 sphingosine kinase 1-like 61.38(n)
    55.39(a)
      100331840  XM_002667539.2  XP_002667585.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sk13 phosphorylation diacylglycerol kinase 42(a)   10B13   --
    worm
    (Caenorhabditis elegans)
    Secernentea C34C6.53 Diacylglycerol kinase catalytic domain
    (presumed)
    28(a)   II(8699253-8701591)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes LCB5(YLR260W)4 Minor sphingoid long-chain base kinase, paralog of more   --   12(665844-667907) 850964  NP_013361.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SPHK11 sphingosine kinase 1 45.78(n)
    39.24(a)
      828239  NM_118274.7  NP_193885.6 
    rice
    (Oryza sativa)
    Liliopsida Os01g07822001 hypothetical protein 45.42(n)
    35.05(a)
      4327845  NM_001050981.1  NP_001044446.1 


    ENSEMBL Gene Tree for SPHK1 (if available)
    TreeFam Gene Tree for SPHK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPHK1 gene
    CERKL2  CERK2  SPHK22  AGK2  
    1 SIMAP similar gene for SPHK1 using alignment to 5 protein entries:     SPHK1_HUMAN (see all proteins):
    SPHK2

    SPHK1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/172 SNPs in SPHK1 are shown (see all 172)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1479095051,2
    C--74378771(+) CAGTGC/TTTCCC 3 -- us2k10--------
    rs3467971,2
    C,F,A,H--74378901(+) CCAGTC/ACCCTC 3 -- us2k126Minor allele frequency- A:0.10NA NS EA WA CSA 3628
    rs1483592461,2
    C--74379060(+) CCCAC-/AGCCGCC 3 -- us2k10--------
    rs1416759661,2
    --74379746(+) CCGCCA/GTAACC 4 -- us2k10--------
    rs1436475231,2
    C--74379899(+) CACGCC/TGAGCC 4 -- us2k10--------
    rs1884854071,2
    --74379961(+) GGCCCC/GCAGGC 4 -- us2k10--------
    rs1931327021,2
    C--74380301(+) TCCCCC/GGGGAG 4 -- us2k10--------
    rs284036081,2
    C--74380574(+) TGGGCA/GCGGGC 4 -- us2k10--------
    rs9087211,2
    C,A--74380786(-) GACTGG/AAGCGC 4 -- ut51 us2k18Minor allele frequency- A:0.09MN EA NA CSA WA 1680
    rs1857145891,2
    --74380842(+) GCCACC/TGTAGG 4 -- ut51 us2k10--------

    HapMap Linkage Disequilibrium report for SPHK1 (74372665 - 74383941 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SPHK1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv23649CNV Loss19812545
    nsv833547CNV Loss17160897
    nsv2145CNV Loss18451855
    nsv833549CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SPHK1
    DNA2.0 Custom Variant and Variant Library Synthesis for SPHK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603730    OMIM disorders: --

    20/50 diseases for SPHK1 (see all 50):    About MalaCards
    hereditary neuralgic amyotrophy    large granular lymphocyte leukemia    glioblastoma    chronic myeloid leukemia
    keloids    estrogen-receptor positive breast cancer    prostate adenocarcinoma    retinal degeneration
    esophageal cancer    oral squamous cell carcinoma    esophagitis    hyperglycemia
    myeloid leukemia    insulinoma    pheochromocytoma    colon cancer
    hypoxia    multiple myeloma    acute myeloid leukemia    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for SPHK1:
    Cancer

    SPHK1 for disorders           About GeneDecksing

    10/17 Novoseek inferred disease relationships for SPHK1 gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioblastoma 44.4 15 19074142 (5), 16106218 (3), 19723667 (2), 17855624 (1) (see all 5)
    glioblastoma multiforme 35.6 4 16106218 (2), 19074142 (1), 19723667 (1)
    renal fibrosis 27 2 19789541 (1), 19657322 (1)
    cancer 25.9 40 18691013 (4), 18638570 (3), 18701480 (3), 18620522 (3) (see all 14)
    tumors 22.4 32 18058224 (5), 20508814 (2), 17699730 (1), 18638570 (1) (see all 11)
    inflammation 18.8 6 17913601 (1), 15191888 (1), 15743396 (1), 19665772 (1) (see all 5)
    necrosis 17.8 6 17699730 (1), 15710602 (1), 20053797 (1), 16269668 (1) (see all 5)
    breast cancer 17.6 15 16194537 (4), 12881510 (2), 18701480 (1), 20110355 (1) (see all 9)
    glioma 9.67 9 19147534 (2), 18055454 (2), 17855624 (2), 17376432 (1)
    colon cancer 8.18 14 18824518 (3), 19240026 (3), 18701480 (1)

    Human Genome Epidemiology (HuGE) Navigator: SPHK1 (1 document)

    Export disorders for SPHK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPHK1 gene, integrated from 9 sources (see all 283):
    (articles sorted by number of sources associating them with SPHK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of functional nuclear export sequences in human sphingosine kinase 1. (PubMed id 14575709)1, 2, 9 Inagaki Y....Igarashi Y. (2003)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Cloning and characterization of a protein kinase A anchoring protein (AKAP)-related protein that interacts with and regulates sphingosine kinase 1 activity. (PubMed id 12080051)1, 2 Lacana E.... Spiegel S. (2002)
    4. Functional characterization of human sphingosine kinase-1. (PubMed id 10802064)1, 2 Nava V.E.... Spiegel S. (2000)
    5. Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes. (PubMed id 10947957)1, 2 Pitson S.M.... Wattenberg B.W. (2000)
    6. Human sphingosine kinase: molecular cloning, functional characterization and tissue distribution. (PubMed id 10863092)1, 2 Melendez A.J.... Takacs L. (2000)
    7. Molecular cloning and functional characterization of murine sphingosine kinase. (PubMed id 9726979)1, 3 Kohama T....Spiegel S. (1998)
    8. Clinical significance of sphingosine kinase-1 expression in human astrocytomas progression and overall patient survival. (PubMed id 18980995)1, 9 Li J....Li M. (2008)
    9. Sphingosine kinase 1 expression is regulated by signaling through PI3K, AKT2, and mTOR in human coronary artery smooth muscle cells. (PubMed id 17482291)1, 9 Francy J.M....Yun J.K. (2007)
    10. Sphingosine kinase 1 localized to the plasma membrane lipid raft microdomain overcomes serum deprivation induced growth inhibition. (PubMed id 19782042)1, 9 Hengst J.A....Yun J.K. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8877 HGNC: 11240 AceView: SPHK1 Ensembl:ENSG00000176170 euGenes: HUgn8877
    ECgene: SPHK1 Kegg: 8877 H-InvDB: SPHK1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPHK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SPHK1 gene:
    Search GeneIP for patents involving SPHK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     EMD Millipore small molecules (inhibitor) for SPHK1
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for SPHK1 (Sphingosine Kinase 1/SPHK1)   Browse Cell Culture Products  
     ELISAs for SPHK1 (Sphingosine Kinase 1/SPHK1)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for SPHK1 (Sphingosine Kinase 1/SPHK1)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SPHK1   OriGene RNAi products in human, mouse, rat for SPHK1  
     OriGene qPCR primer pairs and template standards for SPHK1   OriGene Protein Over-expression Lysate for SPHK1  
     OriGene MassSpec something-or-other for SPHK1   OriGene clones in human, mouse for SPHK1  
     OriGene qSTAR qPCR primer pairs in human, mouse for SPHK1   OriGene Purified Protein for SPHK1  
     OriGene ORF clones in mouse, rat for SPHK1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SPHK1   OriGene Custom Protein Services for SPHK1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPHK1
     QIAGEN SeqTarget long-range PCR primers for resequencing SPHK1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPHK1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPHK1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPHK1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPHK1
     GenScript Custom Purified and Recombinant Proteins Services for SPHK1 GenScript cDNA clones with any tag delivered in your preferred vector for SPHK1
     GenScript Custom Assay Services for SPHK1 GenScript Custom Superior Antibodies Services for SPHK1
     GenScript Custom overexpressing Cell Line Services for SPHK1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for SPHK1 

     Regulatory tfbs in SPHK1 promoter
     Search Chromatin IP Primers for SPHK1
     RT2 qPCR Primer Assay in human, mouse, rat SPHK1
     GNC Network for SPHK1
     SABiosciences PCR Arrays including human, mouse, rat SPHK1
     Tocris compounds for SPHK1
     Proteins and Antibodies for SPHK1
     Cell Lysates for SPHK1
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for SPHK1
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SPHK1 antibodies
     SPHK1 proteins
     SPHK1 lysates
     Antibodies for SPHK1
     See all of Abcam's Antibodies, Kits and Proteins for SPHK1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SPHK1
     Antibodies for SPHK1
     ELISAs for SPHK1
     CLIAs for SPHK1
     Search LifeMap BioReagents cell lines for SPHK1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPHK1
     SwitchGear 3'UTR luciferase reporter plasmids for SPHK1
     SwitchGear Promoter luciferase reporter plasmids for SPHK1
     ThermoFisher Antibody for SPHK1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPHK1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SPHK1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SPHK1
    Customized:
     lentivirus for stable overexpression of SPHK1
     lentivirus expression plasmids for stable overexpression of SPHK1
     adenovirus for overexpression of SPHK1
     LSBio Antibodies in human, mouse, rat for SPHK1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SPHK1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4