SPHAR Gene
protein-coding GIFtS: 30
GCID: GC01P229440
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S-phase response (cyclin related)
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Aliases
for SPHAR gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| S-Phase Response (Cyclin Related)1 2 | | S-Phase Response Protein2 3 | | RP4-803J11.42 | | Protein SPHAR2 | | S-Phase Response (Cyclin-Related)2 |
Export aliases for SPHAR gene to outside databasesPrevious GC identifers: GC01P227887 GC01M225134 GC01P225840 GC01P226401 GC01P225748 GC01P227506 GC01P199930 |
Summaries
for SPHAR gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SPHAR gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPHAR gene promoter:
Bach1 AML1a NF-YA Tal-1beta NF-YB CBF-A CBF-B CP1A NF-Y CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPHAR
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPHAR |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q42.13 Ensembl cytogenetic band: 1q42.13 HGNC cytogenetic band: 1q42.13SPHAR Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P229440: view genomic region
(about GC identifiers)
Start:
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229,440,129 bp from pter |
End:
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229,441,251 bp from pter |
Size:
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1,123 bases |
Orientation:
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plus strand |
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Proteins
for SPHAR gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPHAR_HUMAN, Q15513 (See
protein sequence)Recommended Name: Protein SPHAR Size: 63 amino acids; 7515 Da
Secondary accessions: Q4EW09 Q6NSB9Explore the universe of human proteins at neXtProt for SPHAR: NX_Q15513
SPHAR Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006533.1
ENSEMBL proteins: ENSP00000355649
Human Recombinant Protein Products:
SPHAR Antibody Products:
Assay Products for SPHAR: |
Protein
Domains /
Families
for SPHAR gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q15513 |
Function
for SPHAR gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPHAR
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPHAR
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SPHAR (NM_006542) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPHAR | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPHAR |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPHAR |
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Pathways & Interactions
for SPHAR gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPHAR
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
SPHAR for ontologies About GeneDecksing
|
Drugs & Compounds
for SPHAR gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPHAR
Search CenterWatch for drugs/clinical trials and news about SPHAR
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Transcripts
for SPHAR gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPHAR gene: NM_006542.3 1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000366688(uc001htk.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPHAR
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPHAR
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SPHAR (NM_006542) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPHAR | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPHAR |
24/226 AceView cDNA sequences (see all 226): CB529964 AA099743 BE350016 BM927705 CD516788 AI479971 BQ416747 AI274226 BQ055622 AI015648 AI803193 BQ650239 CR615332 CR602754 BE904815 F01612 NM_004578 AF498934 AW054692 CD672077 AI394208 AA652902 AW510865 CR604213
GeneLoc Exon Structure
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Expression
for SPHAR gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPHAR expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SPHAR Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPHAR
SABiosciences Custom PCR Arrays for SPHAR
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPHAR
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SPHAR | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPHAR | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPHAR | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPHAR |
Orthologs
for SPHAR gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for SPHAR (if available)
TreeFam Gene Tree for SPHAR (if available) |
Paralogs
for SPHAR gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SPHAR gene
SPHAR for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SPHAR
PGOHUM00000249315
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Genomic Variants
for SPHAR gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for SPHAR (229440129 - 229441251 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SPHAR: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for SPHAR gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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SPHAR for disorders About GeneDecksing
2  diseases for SPHAR: About MalaCardsfanconi's anemia anemia
Export disorders for SPHAR gene to outside databases
|
Publications
for SPHAR gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPHAR gene integrated from 9 sources:
(articles sorted by number of sources associating them with SPHAR) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Irreversible repression of DNA synthesis in Fanconi anemia cells is alleviated by the product of a novel cyclin-related gene. (PubMed id 7799938)1, 2, 3 Digweed M....Sperling K. (1995)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for SPHAR gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SPHAR gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing SPHAR gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPHAR gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SPHAR | Pharmacogenomics, SNPs, Pathways | | NIEHS-SNPs | http://egp.gs.washington.edu/data/sphar/ |
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About This Section
| Patent Information for SPHAR gene:
Search GeneIP for patents involving SPHAR
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPHAR gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPHAR | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPHAR | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPHAR | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPHAR | | OriGene 3'-UTR Clone for SPHAR | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPHAR | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPHAR | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SPHAR | | OriGene Custom Protein Services for SPHAR | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPHAR | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPHAR | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPHAR | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPHAR | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPHAR | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPHAR |
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 | | | SPHAR Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPHAR |
|  |  |  | | | | Search ThermoFisher Antibodies for SPHAR |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPHAR |
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