SPG21 Gene
protein-coding GIFtS: 51
GCID: GC15M065255
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|
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
| |
Aliases
for SPG21 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Spastic Paraplegia 21 (Autosomal Recessive, Mast Syndrome)1 2 | | Spastic Paraplegia 21 Autosomal Recessive Mast Syndrome Protein2 3 | | ACP331 2 3 5 | | Spastic Paraplegia 21 Protein2 3 | | MAST1 2 5 | | BM-0191 | | GL0101 2 | | MASPARDIN2 | | Acid Cluster Protein 332 3 | | Maspardin1 |
Export aliases for SPG21 gene to outside databasesPrevious GC identifers: GC13U900001 GC15M062972 GC15M063042 GC15M042080 |
Summaries
for SPG21 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SPG21:
The protein encoded by this gene was identified by a two-hybrid screen using CD4 as the bait. It binds to thehydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction withCD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that thisgene product modulates the stimulatory activity of CD4. At least three different transcript variants encoding twodifferent isoforms have been found for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SPG21_HUMAN, Q9NZD8Function: May play a role as a negative regulatory factor in CD4-dependent T-cell activation
Gene Wiki entry for SPG21
|
Genomic Views
for SPG21 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPG21 gene promoter:
AREB6 Max1 NF-kappaB NF-kappaB1 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPG21
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPG21 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q21-q22 Ensembl cytogenetic band: 15q22.31 HGNC cytogenetic band: 15q21-q22SPG21 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M065255: view genomic region
(about GC identifiers)
Start:
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65,255,362 bp from pter |
End:
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65,282,648 bp from pter |
Size:
|
27,287 bases |
Orientation:
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minus strand |
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Proteins
for SPG21 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPG21_HUMAN, Q9NZD8 (See
protein sequence)Recommended Name: Maspardin Size: 308 amino acids; 34960 Da
Subunit: Interacts with CD4. Interacts with ALDH16A1
Subcellular location: Cytoplasm, cytosol. Membrane; Peripheral membrane protein. Endosome membrane; Peripheral membraneprotein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Note=Partially localized in thecytosol but also accumulated on an intracellular vesicular compartment. Colocalizes with CD4 on endosomal/trans-Golginetwork
Secondary accessions: B4DW44 Q6ZMB6Alternative splicing: 2 isoforms: Q9NZD8-1 Q9NZD8-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SPG21: NX_Q9NZD8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NZD8
SPG21 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001121361.1 NP_001121362.1 NP_057714.1
ENSEMBL proteins: ENSP00000204566 ENSP00000456365 ENSP00000404111 ENSP00000452865 ENSP00000394846 ENSP00000452728 ENSP00000453541 ENSP00000453333 ENSP00000453362 ENSP00000453167 ENSP00000453658
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
SPG21 for ontologies About GeneDecksing
SPG21 Antibody Products:
Assay Products for SPG21: |
Protein
Domains /
Families
for SPG21 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SPG21 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NZD8ProtoNet protein and cluster: Q9NZD8 UniProtKB/Swiss-Prot: SPG21_HUMAN, Q9NZD8Similarity: Belongs to the AB hydrolase superfamily |
Function
for SPG21 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SPG21_HUMAN, Q9NZD8Function: May play a role as a negative regulatory factor in CD4-dependent T-cell activation
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPG21 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPG21 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
SPG21 for ontologies About GeneDecksing
|
Pathways & Interactions
for SPG21 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SPG21
STRING Interaction
Network Preview (showing 5 interactants - click image to see 16)
5/25 Interacting proteins for SPG21 (Q9NZD82, 3 ENSP000002045664) via UniProtKB, MINT, STRING, and/or I2D (see all 25)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| RTN4 | Q9NQC32, 3, ENSP000003378384 | MINT-67816 I2D:
score=5 STRING: ENSP00000337838 | | CTPS2 | Q9NRF82, 3, ENSP000003522224 | MINT-66818 I2D:
score=5 STRING: ENSP00000352222 | | GGA2 | Q9UJY42, 3, ENSP000003119624 | MINT-66286 I2D:
score=5 STRING: ENSP00000311962 | | ZNF263 | O149782, 3, ENSP000002190694 | MINT-67414 I2D:
score=5 STRING: ENSP00000219069 | | CUTC | Q9NTM92, 3, ENSP000003595074 | MINT-67609 I2D:
score=4 STRING: ENSP00000359507 |
About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
SPG21 for ontologies About GeneDecksing
|
Drugs & Compounds
for SPG21 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPG21
Search CenterWatch for drugs/clinical trials and news about SPG21
|
Transcripts
for SPG21 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPG21 gene (3 alternative transcripts): NM_001127889.1 NM_001127890.1 NM_016630.3 Unigene Cluster for SPG21: Spastic paraplegia 21 (autosomal recessive, Mast syndrome) Hs.242458 [show with all ESTs]Unigene Representative Sequence: AL13731214 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000204566(uc002aoe.3 uc010bhb.3) ENST00000559199 ENST00000433215(uc002aod.3)
ENST00000561078 ENST00000416889 ENST00000558765 ENST00000557795 ENST00000560564
ENST00000559677 ENST00000558943 ENST00000558415 ENST00000560878 ENST00000558339
ENST00000561088
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPG21 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPG21 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): SPG21 (NM_001127889) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPG21 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPG21 |
Additional cDNA sequence: AF208861.1 AF212231.1 AK123725.1 AK172849.1 AK225527.1 AK301362.1 AK312943.1 AL137312.1 BC000244.1 14 DOTS entries: DT.454639 DT.91762304 DT.91832373 DT.95138500 DT.91762303 DT.100820989 DT.100820993 DT.91844063 DT.91697318 DT.95121964 DT.100029158 DT.100820992 DT.70101577 DT.91762313 24/349 AceView cDNA sequences (see all 349): BU195993 AA370209 CD251190 NM_016630 AA761084 CA447603 BM729181 BU857034 AA370208 BQ631586 BQ425838 AA452340 BU631376 CN482514 BU150007 R81568 BF087712 BP378141 BM666585 BU631471 CR597831 AA463198 BM682107 AA953985
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SPG21 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
|---|
|
| SP1: | | | | | - | | - | | - | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SPG21
|
Expression
for SPG21 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPG21 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCACTACCC
About this image
See SPG21 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPG21
SOURCE GeneReport for Unigene cluster: Hs.242458
UniProtKB/Swiss-Prot: SPG21_HUMAN, Q9NZD8Tissue specificity: Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle,kidney and pancreas. Expressed in J.CaM1.6, HuT 78 and HeLa cell lines (at protein level)
SABiosciences Custom PCR Arrays for SPG21
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPG21
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPG21 |
Orthologs
for SPG21 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SPG21 gene from 8/24 species (see all 24) About this table
ENSEMBL Gene Tree for SPG21 (if available)
TreeFam Gene Tree for SPG21 (if available) |
Paralogs
for SPG21 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SPG21 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SPG21 (65255362 - 65282648 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SPG21: --
Human Gene Mutation Database (HGMD): SPG21
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPG21 |
|
Disorders
/ Diseases
for SPG21 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SPG21 for disorders About GeneDecksing
OMIM gene information: 608181
OMIM disorders: 248900
UniProtKB/Swiss-Prot: SPG21_HUMAN, Q9NZD8
Defects in SPG21 are the cause of spastic paraplegia autosomal recessive type 21 (SPG21) [MIM:248900]; alsoknown as Mast syndrome. Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual,progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quitevariable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, anddragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, orthe weakness and stiffness may spread to other parts of the body. SPG21 is associated with dementia and other centralnervous system abnormalities. Subtle childhood abnormalities may be present, but the main features develop in earlyadulthood. The disease is slowly progressive, and cerebellar and extrapyramidal signs are also found in patients withadvanced disease. Patients have a thin corpus callosum and white-matter abnormalities
19  diseases for SPG21: About MalaCardsspastic paraplegia mast syndrome paraplegia spasticity
ruptured abdominal aortic aneurysm abdominal aortic aneurysm aortic aneurysm hereditary spastic paraplegia
substance abuse corpus callosum cerebrovascular accident compartment syndrome
gonorrhea multiple sclerosis hepatitis b rhinitis
dementia hepatitis malaria
1 disease from the University of Copenhagen DISEASES database for SPG21:Paraplegia Export disorders for SPG21 gene to outside databases
|
Publications
for SPG21 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPG21 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with SPG21) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning of ACP33 as a novel intracellular ligand of CD4. (PubMed id 11113139)1, 2, 3, 9 Zeitlmann L.... Kolanus W. (2001)
- Maspardin is mutated in Mast syndrome, a complicated form of hereditary spastic paraplegia associated with dementia. (PubMed id 14564668)1, 2, 3, 9 Simpson M.A.... Crosby A.H. (2003)
- Interaction of the SPG21 protein ACP33/maspardin with the aldehyde dehydrogenase ALDH16A1. (PubMed id 19184135)1, 2, 9 Hanna M.C. and Blackstone C. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for SPG21 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SPG21 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SPG21 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPG21 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SPG21 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SPG21 gene:
Search GeneIP for patents involving SPG21
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPG21 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPG21 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPG21 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPG21 | | | OriGene Protein Over-expression Lysate for SPG21 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPG21 | | OriGene 3'-UTR Clone for SPG21 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPG21 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPG21 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SPG21 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPG21 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPG21 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPG21 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPG21 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPG21 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPG21 |
| |
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| |  |  |  |  | | | | | | Recombinant Protein for SPG21 |
|
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 | | | SPG21 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPG21 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPG21 |
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