SPESP1 Gene
protein-coding GIFtS: 34
GCID: GC15P069112
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sperm equatorial segment protein 1
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Aliases
for SPESP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sperm Equatorial Segment Protein 11 2 | | SP-ESP1 2 3 | | Equatorial Segment Protein2 3 | | Glycosylated 38 KDa Sperm Protein C-7/82 3 | | ESP2 3 |
Export aliases for SPESP1 gene to outside databasesPrevious GC identifers: GC00U990975 GC15P066802 GC15P066938 GC15P067010 GC15P067011 GC15P069224 GC15P046056 |
Summaries
for SPESP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SPESP1:
The encoded protein is a human alloantigen involved in sperm-egg binding and fusion. (provided by RefSeq, Apr 2010)
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Genomic Views
for SPESP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPESP1 gene promoter:
RFX1 MIF-1 HNF-4alpha2 Evi-1 HNF-4alpha1 POU2F1 POU2F1b POU2F1a HOXA5 POU2F1c
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPESP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPESP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q23 Ensembl cytogenetic band: 15q23 HGNC cytogenetic band: 15q22.31SPESP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P069112: view genomic region
(about GC identifiers)
Start:
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69,110,560 bp from pter |
End:
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69,239,150 bp from pter |
Size:
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128,591 bases |
Orientation:
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plus strand |
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Proteins
for SPESP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPESP_HUMAN, Q6UW49 (See
protein sequence)Recommended Name: Sperm equatorial segment protein 1 precursor Size: 350 amino acids; 38931 Da
Subcellular location: Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Small proacrosomal granules (during theGolgi phase), enlarged acrosomal vesicles (during the cap phase), acrosome (during the elongating phase), equatorialsegment of the acrosome (during the maturation phase)
Secondary accessions: Q8NG22 Q8WVH8Explore the universe of human proteins at neXtProt for SPESP1: NX_Q6UW49
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6UW49
SPESP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_663633.1
ENSEMBL proteins: ENSP00000312284
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001669 | acrosomal vesicle |
IEA | -- |
SPESP1 for ontologies About GeneDecksing
SPESP1 Antibody Products:
Assay Products for SPESP1: |
Protein
Domains /
Families
for SPESP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SPESP1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6UW49ProtoNet protein and cluster: Q6UW49 UniProtKB/Swiss-Prot: SPESP_HUMAN, Q6UW49Similarity: Belongs to the SPESP1 family |
Function
for SPESP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPESP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPESP1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SPESP1 (NM_145658) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPESP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPESP1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPESP1 |
1 GenomeRNAi human phenotype for SPESP1:
Animal Models:
Mouse knock-out Spesp1tm1Osb for SPESP1
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Spesp1):
SPESP1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SPESP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPESP1
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0007340 | acrosome reaction |
IEA | -- | | GO:0007342 | fusion of sperm to egg plasma membrane |
IEA | -- |
SPESP1 for ontologies About GeneDecksing
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Drugs & Compounds
for SPESP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPESP1
Search CenterWatch for drugs/clinical trials and news about SPESP1 / SPESP
|
Transcripts
for SPESP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPESP1 gene: NM_145658.3 3 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000560188 ENST00000310673(uc002arn.2) ENST00000561467
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPESP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPESP1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SPESP1 (NM_145658) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPESP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPESP1 |
24/94 AceView cDNA sequences (see all 94): CD107927 BU625703 AI797949 AY166601 BQ215955 BE045942 AI990773 BQ013471 AI652853 BC017998 AF353088 BF434176 BM564110 NM_024505 NM_145658 BM929516 BI826643 AF325189 AF325190 CR610432 AY358983 H52859 AF353089 AW340601
GeneLoc Exon Structure
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Expression
for SPESP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPESP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SPESP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPESP1
UniProtKB/Swiss-Prot: SPESP_HUMAN, Q6UW49Tissue specificity: Highly expressed in testis, where it is localized in the acrosome of postmeiotic stages ofspermiogenesis (round and elongating spermatids and in ejaculated spermatozoa) (at protein level). Poorly expressed inplacenta and fetal lung
SABiosciences Custom PCR Arrays for SPESP1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPESP1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPESP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPESP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPESP1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPESP1 |
Orthologs
for SPESP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for SPESP1 gene from 1/7 species (see all 7) About this table
ENSEMBL Gene Tree for SPESP1 (if available)
TreeFam Gene Tree for SPESP1 (if available) |
Paralogs
for SPESP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SPESP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for SPESP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SPESP1 for disorders About MalaCards
SPESP1 for disorders About GeneDecksing
OMIM gene information: 609399
OMIM disorders: --
Export disorders for SPESP1 gene to outside databases
|
Publications
for SPESP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPESP1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SPESP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Equatorial segment protein defines a discrete acrosomal subcompartment persisting throughout acrosomal biogenesis. (PubMed id 12773409)1, 2, 3, 9 Wolkowicz M.J.... Herr J.C. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Equatorial segment protein (ESP) is a human alloantigen involved in sperm-egg binding and fusion. (PubMed id 17978344)1, 9 Wolkowicz M.J....Herr J.C. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Immunogenicity of a multi-component recombinant human acrosomal protein vaccine in female Macaca fascicularis. (PubMed id 17643494)9 Kurth B.E....Herr J.C. (2008)
- Genogrouping and incidence of virulence factors of Enterococcus faecalis in liver transplant patients differ from blood culture and fecal isolates. (PubMed id 11930322)9 Waar K....Degener J.E. (2002)
- A novel putative enterococcal pathogenicity island linked to the esp virulence gene of Enterococcus faecium and associated with epidemicity. (PubMed id 14729692)9 Leavis H....Willems R.J. (2004)
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External Searches for SPESP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SPESP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SPESP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPESP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SPESP1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for SPESP1 gene:
Search GeneIP for patents involving SPESP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPESP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPESP1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPESP1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPESP1 | | | OriGene Protein Over-expression Lysate for SPESP1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPESP1 | | OriGene 3'-UTR Clone for SPESP1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPESP1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPESP1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SPESP1 | | OriGene Custom Protein Services for SPESP1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPESP1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPESP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPESP1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPESP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPESP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPESP1 |
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 |  |  |  | |
| | | | Search Tocris compounds for SPESP1 |
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 | | | SPESP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPESP1 |
|  |  |  | | | | Search ThermoFisher Antibodies for SPESP1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPESP1 |
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