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Aliases for SPESP1 Gene

Aliases for SPESP1 Gene

  • Sperm Equatorial Segment Protein 1 2 3
  • Glycosylated 38 KDa Sperm Protein C-7/8 3 4
  • Equatorial Segment Protein 3 4
  • SP-ESP 3 4
  • ESP 3 4

External Ids for SPESP1 Gene

Previous GeneCards Identifiers for SPESP1 Gene

  • GC00U990975
  • GC15P066802
  • GC15P066938
  • GC15P067010
  • GC15P067011
  • GC15P069224
  • GC15P046056
  • GC15P069112

Summaries for SPESP1 Gene

Entrez Gene Summary for SPESP1 Gene

  • The encoded protein is a human alloantigen involved in sperm-egg binding and fusion. [provided by RefSeq, Apr 2010]

GeneCards Summary for SPESP1 Gene

SPESP1 (Sperm Equatorial Segment Protein 1) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPESP1 Gene

Genomics for SPESP1 Gene

Regulatory Elements for SPESP1 Gene

Genomic Location for SPESP1 Gene

Start:
68,818,221 bp from pter
End:
68,946,811 bp from pter
Size:
128,591 bases
Orientation:
Plus strand

Genomic View for SPESP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPESP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPESP1 Gene

Proteins for SPESP1 Gene

  • Protein details for SPESP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UW49-SPESP_HUMAN
    Recommended name:
    Sperm equatorial segment protein 1
    Protein Accession:
    Q6UW49
    Secondary Accessions:
    • Q8NG22
    • Q8WVH8

    Protein attributes for SPESP1 Gene

    Size:
    350 amino acids
    Molecular mass:
    38931 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPESP1 Gene

Proteomics data for SPESP1 Gene at MOPED

Post-translational modifications for SPESP1 Gene

  • Glycosylation at Asn128
  • Modification sites at PhosphoSitePlus

Other Protein References for SPESP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPESP1 Gene

Domains for SPESP1 Gene

Protein Domains for SPESP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPESP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UW49

UniProtKB/Swiss-Prot:

SPESP_HUMAN :
  • Q6UW49
Family:
  • Belongs to the SPESP1 family.
genes like me logo Genes that share domains with SPESP1: view

No data available for Gene Families for SPESP1 Gene

Function for SPESP1 Gene

Gene Ontology (GO) - Molecular Function for SPESP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SPESP1: view

Phenotypes for SPESP1 Gene

MGI mutant phenotypes for SPESP1:
inferred from 1 alleles
GenomeRNAi human phenotypes for SPESP1:
genes like me logo Genes that share phenotypes with SPESP1: view

Animal Models for SPESP1 Gene

MGI Knock Outs for SPESP1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPESP1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SPESP1 Gene

Localization for SPESP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPESP1 Gene

Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Small proacrosomal granules (during the Golgi phase), enlarged acrosomal vesicles (during the cap phase), acrosome (during the elongating phase), equatorial segment of the acrosome (during the maturation phase).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPESP1 Gene COMPARTMENTS Subcellular localization image for SPESP1 gene
Compartment Confidence
extracellular 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SPESP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
genes like me logo Genes that share ontologies with SPESP1: view

Pathways for SPESP1 Gene

SuperPathways for SPESP1 Gene

No Data Available

Interacting Proteins for SPESP1 Gene

Gene Ontology (GO) - Biological Process for SPESP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0007340 acrosome reaction IEA --
GO:0007342 fusion of sperm to egg plasma membrane IEA --
genes like me logo Genes that share ontologies with SPESP1: view

No data available for Pathways by source for SPESP1 Gene

Transcripts for SPESP1 Gene

mRNA/cDNA for SPESP1 Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPESP1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SPESP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPESP1 Gene

No ASD Table

Relevant External Links for SPESP1 Gene

GeneLoc Exon Structure for
SPESP1
ECgene alternative splicing isoforms for
SPESP1

Expression for SPESP1 Gene

mRNA expression in normal human tissues for SPESP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPESP1 Gene

This gene is overexpressed in Testis (17.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SPESP1 Gene

mRNA Expression by UniProt/SwissProt for SPESP1 Gene

Q6UW49-SPESP_HUMAN
Tissue specificity: Highly expressed in testis, where it is localized in the acrosome of postmeiotic stages of spermiogenesis (round and elongating spermatids and in ejaculated spermatozoa) (at protein level). Poorly expressed in placenta and fetal lung.
genes like me logo Genes that share expressions with SPESP1: view

In Situ Assay Products

Orthologs for SPESP1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPESP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPESP1 35
  • 99.12 (n)
  • 97.89 (a)
SPESP1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPESP1 35
  • 78.31 (n)
  • 62.5 (a)
SPESP1 36
  • 57 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPESP1 35
  • 78.02 (n)
  • 63.09 (a)
SPESP1 36
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spesp1 35
  • 59.21 (n)
  • 47.83 (a)
Spesp1 16
Spesp1 36
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPESP1 36
  • 28 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spesp1 35
  • 60.74 (n)
  • 51.67 (a)
Species with no ortholog for SPESP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPESP1 Gene

ENSEMBL:
Gene Tree for SPESP1 (if available)
TreeFam:
Gene Tree for SPESP1 (if available)

Paralogs for SPESP1 Gene

No data available for Paralogs for SPESP1 Gene

Variants for SPESP1 Gene

Sequence variations from dbSNP and Humsavar for SPESP1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
VAR_023738 -
VAR_031430 -
VAR_056994 -

Structural Variations from Database of Genomic Variants (DGV) for SPESP1 Gene

Variant ID Type Subtype PubMed ID
nsv1584 CNV Loss 18451855

Relevant External Links for SPESP1 Gene

HapMap Linkage Disequilibrium report
SPESP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPESP1 Gene

Disorders for SPESP1 Gene

No disorders were found for SPESP1 Gene.

No data available for UniProtKB/Swiss-Prot for SPESP1 Gene

Publications for SPESP1 Gene

  1. Equatorial segment protein defines a discrete acrosomal subcompartment persisting throughout acrosomal biogenesis. (PMID: 12773409) Wolkowicz M.J. … Herr J.C. (Biol. Reprod. 2003) 2 3 4 23
  2. Equatorial segment protein (ESP) is a human alloantigen involved in sperm-egg binding and fusion. (PMID: 17978344) Wolkowicz M.J. … Herr J.C. (J. Androl. 2008) 3 23
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for SPESP1 Gene

Sources for SPESP1 Gene

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