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Aliases for SPESP1 Gene

Aliases for SPESP1 Gene

  • Sperm Equatorial Segment Protein 1 2 3 5
  • Glycosylated 38 KDa Sperm Protein C-7/8 3 4
  • Equatorial Segment Protein 3 4
  • SP-ESP 3 4
  • ESP 3 4

External Ids for SPESP1 Gene

Previous GeneCards Identifiers for SPESP1 Gene

  • GC00U990975
  • GC15P066802
  • GC15P066938
  • GC15P067010
  • GC15P067011
  • GC15P069224
  • GC15P046056
  • GC15P069112

Summaries for SPESP1 Gene

Entrez Gene Summary for SPESP1 Gene

  • The encoded protein is a human alloantigen involved in sperm-egg binding and fusion. [provided by RefSeq, Apr 2010]

GeneCards Summary for SPESP1 Gene

SPESP1 (Sperm Equatorial Segment Protein 1) is a Protein Coding gene. Diseases associated with SPESP1 include Andersen Syndrome.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPESP1 Gene

Genomics for SPESP1 Gene

Regulatory Elements for SPESP1 Gene

Enhancers for SPESP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G068777 1.2 Ensembl ENCODE dbSUPER 10.7 -42.2 -42179 1.5 PAF1 BCOR ZNF175 ZMYM3 CEBPG ZNF518A NR2F2 TCF12 ZNF335 ZNF589 ANP32A SPESP1 ENSG00000137808 NOX5 MIR4312 CARSP1
GH15G068725 1.1 Ensembl ENCODE 10.5 -92.1 -92095 0.9 HDAC1 ZFP64 ZNF766 SCRT2 SP5 CEBPB ZEB2 ZNF592 TGIF2 NFIL3 ANP32A SPESP1 ENSG00000137808 NOX5 GC15P068742 GC15M068584
GH15G069012 1 dbSUPER 10.9 +197.8 197841 7.1 ZFP64 SIN3A ZNF766 FOS MCM3 SP5 ZNF623 ZNF592 NFIL3 MIER3 NOX5 ENSG00000137808 SPESP1 PIR33809 GC15P068964
GH15G068729 1 Ensembl ENCODE 10.5 -87.6 -87568 2.1 CTCF KLF1 ZSCAN26 ZSCAN4 KLF17 ZNF384 RAD21 ZFHX2 GATA3 SMC3 ANP32A SPESP1 ENSG00000137808 NOX5 SKOR1 GC15P068742 GC15M068584
GH15G068899 0.8 ENCODE 12.3 +81.7 81686 1.5 SOX13 TFAP4 FOXA2 CEBPG ZNF644 THRB TEAD3 NR2F6 THAP11 SOX5 NOX5 ENSG00000137808 SPESP1 ANP32A LOC390600
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPESP1 on UCSC Golden Path with GeneCards custom track

Promoters for SPESP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000078568 400 1000 MAZ PKNOX1 ZNF687 RFX1 NRF1 SIN3A MAX MNT ZBTB40 ZNF592

Genomic Location for SPESP1 Gene

68,818,221 bp from pter
68,946,811 bp from pter
128,591 bases
Plus strand

Genomic View for SPESP1 Gene

Genes around SPESP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPESP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPESP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPESP1 Gene

Proteins for SPESP1 Gene

  • Protein details for SPESP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sperm equatorial segment protein 1
    Protein Accession:
    Secondary Accessions:
    • Q8NG22
    • Q8WVH8

    Protein attributes for SPESP1 Gene

    350 amino acids
    Molecular mass:
    38931 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPESP1 Gene

Post-translational modifications for SPESP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPESP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPESP1 Gene

Domains & Families for SPESP1 Gene

Protein Domains for SPESP1 Gene


Suggested Antigen Peptide Sequences for SPESP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPESP1 family.
  • Belongs to the SPESP1 family.
genes like me logo Genes that share domains with SPESP1: view

No data available for Gene Families for SPESP1 Gene

Function for SPESP1 Gene

genes like me logo Genes that share phenotypes with SPESP1: view

Animal Models for SPESP1 Gene

MGI Knock Outs for SPESP1:

Animal Model Products

CRISPR Products

miRNA for SPESP1 Gene

miRTarBase miRNAs that target SPESP1

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPESP1 Gene

Localization for SPESP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPESP1 Gene

Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Small proacrosomal granules (during the Golgi phase), enlarged acrosomal vesicles (during the cap phase), acrosome (during the elongating phase), equatorial segment of the acrosome (during the maturation phase).

Gene Ontology (GO) - Cellular Components for SPESP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IBA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with SPESP1: view

No data available for Subcellular locations from COMPARTMENTS for SPESP1 Gene

Pathways & Interactions for SPESP1 Gene

SuperPathways for SPESP1 Gene

No Data Available

Interacting Proteins for SPESP1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000312284 Q6UW49-SPESP_HUMAN for SPESP1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SPESP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007340 acrosome reaction IBA --
GO:0007342 fusion of sperm to egg plasma membrane IBA --
genes like me logo Genes that share ontologies with SPESP1: view

No data available for Pathways by source and SIGNOR curated interactions for SPESP1 Gene

Drugs & Compounds for SPESP1 Gene

No Compound Related Data Available

Transcripts for SPESP1 Gene

mRNA/cDNA for SPESP1 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPESP1 Gene

No ASD Table

Relevant External Links for SPESP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPESP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPESP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPESP1 Gene

This gene is overexpressed in Testis (x17.8).

Protein differential expression in normal tissues from HIPED for SPESP1 Gene

This gene is overexpressed in Testis (44.8) and Heart (24.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPESP1 Gene

Protein tissue co-expression partners for SPESP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SPESP1 Gene:


mRNA Expression by UniProt/SwissProt for SPESP1 Gene:

Tissue specificity: Highly expressed in testis, where it is localized in the acrosome of postmeiotic stages of spermiogenesis (round and elongating spermatids and in ejaculated spermatozoa) (at protein level). Poorly expressed in placenta and fetal lung.

Evidence on tissue expression from TISSUES for SPESP1 Gene

  • Skin(4)
genes like me logo Genes that share expression patterns with SPESP1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SPESP1 Gene

Orthologs for SPESP1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPESP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPESP1 34 35
  • 99.12 (n)
(Bos Taurus)
Mammalia SPESP1 34 35
  • 78.31 (n)
(Canis familiaris)
Mammalia SPESP1 34 35
  • 78.02 (n)
(Rattus norvegicus)
Mammalia Spesp1 34
  • 60.74 (n)
(Mus musculus)
Mammalia Spesp1 34 16 35
  • 59.21 (n)
(Ornithorhynchus anatinus)
Mammalia SPESP1 35
  • 28 (a)
Species where no ortholog for SPESP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPESP1 Gene

Gene Tree for SPESP1 (if available)
Gene Tree for SPESP1 (if available)

Paralogs for SPESP1 Gene

No data available for Paralogs for SPESP1 Gene

Variants for SPESP1 Gene

Sequence variations from dbSNP and Humsavar for SPESP1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000107522 -- 68,944,900(+) GGAAA(-/CT)CTGAT intron-variant
rs1000132071 -- 68,939,082(+) GAAGT(A/G)CAGGC intron-variant
rs1000145988 -- 68,929,681(+) TATTT(C/T)TAGTA upstream-variant-2KB
rs1000342206 -- 68,942,500(+) GTATT(C/T)TTATC intron-variant
rs1000415861 -- 68,942,231(+) TTATA(G/T)CTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPESP1 Gene

Variant ID Type Subtype PubMed ID
nsv1584 CNV deletion 18451855

Variation tolerance for SPESP1 Gene

Residual Variation Intolerance Score: 34.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.22; 62.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPESP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPESP1 Gene

Disorders for SPESP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SPESP1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
andersen syndrome
  • andersen cardiodysrhythmic periodic paralysis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SPESP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SPESP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPESP1 Gene

Publications for SPESP1 Gene

  1. Equatorial segment protein defines a discrete acrosomal subcompartment persisting throughout acrosomal biogenesis. (PMID: 12773409) Wolkowicz M.J. … Herr J.C. (Biol. Reprod. 2003) 2 3 4 22 64
  2. Equatorial segment protein (ESP) is a human alloantigen involved in sperm-egg binding and fusion. (PMID: 17978344) Wolkowicz M.J. … Herr J.C. (J. Androl. 2008) 3 22 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  5. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PMID: 23503679) Zhu J. … Elledge S.J. (Nat. Biotechnol. 2013) 3 64

Products for SPESP1 Gene

Sources for SPESP1 Gene

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