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Aliases for SPERT Gene

Aliases for SPERT Gene

  • Spermatid Associated 2 3 5
  • Spermatid Flower-Like Structure Protein 2 3
  • Protein Chibby Homolog 2 3 4
  • CBY2 3 4
  • Testis Specific Leucine Zipper Protein Nurit 2
  • Testis-Specific Leucine Zipper Protein Nurit 3
  • Novel Leucine Zipper Testicular Protein 3
  • Testicular Tissue Protein Li 182 3
  • Chibby Homolog 2 (Drosophila) 2
  • NURIT 3

External Ids for SPERT Gene

Previous GeneCards Identifiers for SPERT Gene

  • GC13P045175
  • GC13P046276
  • GC13P027073

Summaries for SPERT Gene

GeneCards Summary for SPERT Gene

SPERT (Spermatid Associated) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPERT Gene

Genomics for SPERT Gene

Regulatory Elements for SPERT Gene

Enhancers for SPERT Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SPERT on UCSC Golden Path with GeneCards custom track

Genomic Location for SPERT Gene

45,702,292 bp from pter
45,714,559 bp from pter
12,268 bases
Plus strand

Genomic View for SPERT Gene

Genes around SPERT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPERT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPERT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPERT Gene

Proteins for SPERT Gene

  • Protein details for SPERT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Spermatid-associated protein
    Protein Accession:
    Secondary Accessions:
    • A8K8I5
    • Q8NHV2

    Protein attributes for SPERT Gene

    448 amino acids
    Molecular mass:
    51570 Da
    Quaternary structure:
    • Homodimer. Binds to NEK1 (By similarity).

    Alternative splice isoforms for SPERT Gene


neXtProt entry for SPERT Gene

Proteomics data for SPERT Gene at MOPED

Post-translational modifications for SPERT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPERT Gene

No data available for DME Specific Peptides for SPERT Gene

Domains & Families for SPERT Gene

Protein Domains for SPERT Gene


Suggested Antigen Peptide Sequences for SPERT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the chibby family. SPERT subfamily.
  • Belongs to the chibby family. SPERT subfamily.
genes like me logo Genes that share domains with SPERT: view

No data available for Gene Families for SPERT Gene

Function for SPERT Gene

Phenotypes for SPERT Gene

GenomeRNAi human phenotypes for SPERT:
genes like me logo Genes that share phenotypes with SPERT: view

Animal Model Products

miRNA for SPERT Gene

miRTarBase miRNAs that target SPERT

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPERT Gene

Localization for SPERT Gene

Subcellular locations from

Jensen Localization Image for SPERT Gene COMPARTMENTS Subcellular localization image for SPERT gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SPERT Gene

Pathways & Interactions for SPERT Gene

SuperPathways for SPERT Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPERT Gene


No data available for Pathways by source and SIGNOR curated interactions for SPERT Gene

Drugs & Compounds for SPERT Gene

(1) Drugs for SPERT Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SPERT: view

Transcripts for SPERT Gene

mRNA/cDNA for SPERT Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPERT Gene

Spermatid associated:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPERT Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1: -
SP2: - -

Relevant External Links for SPERT Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPERT Gene

mRNA expression in normal human tissues for SPERT Gene

mRNA differential expression in normal tissues according to GTEx for SPERT Gene

This gene is overexpressed in Testis (x52.2).

Protein differential expression in normal tissues from HIPED for SPERT Gene

This gene is overexpressed in Heart (48.2) and Testis (16.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPERT Gene

SOURCE GeneReport for Unigene cluster for SPERT Gene Hs.186363

genes like me logo Genes that share expression patterns with SPERT: view

Protein tissue co-expression partners for SPERT Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SPERT Gene

Orthologs for SPERT Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPERT Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SPERT 35
  • 86.94 (n)
  • 81.93 (a)
  • 81 (a)
(Canis familiaris)
Mammalia SPERT 35
  • 83.82 (n)
  • 82.55 (a)
  • 80 (a)
(Mus musculus)
Mammalia Spert 35
  • 81.95 (n)
  • 79.55 (a)
Spert 16
Spert 36
  • 78 (a)
(Rattus norvegicus)
Mammalia Spert 35
  • 82.21 (n)
  • 79.37 (a)
(Monodelphis domestica)
Mammalia SPERT 36
  • 56 (a)
(Pan troglodytes)
Mammalia SPERT 36
  • 99 (a)
(Gallus gallus)
Aves SPERT 35
  • 50.29 (n)
  • 36.59 (a)
  • 30 (a)
(Anolis carolinensis)
Reptilia SPERT 36
  • 36 (a)
Species with no ortholog for SPERT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPERT Gene

Gene Tree for SPERT (if available)
Gene Tree for SPERT (if available)

Paralogs for SPERT Gene

No data available for Paralogs for SPERT Gene

Variants for SPERT Gene

Sequence variations from dbSNP and Humsavar for SPERT Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs7317245 - 45,714,010(+) TGCGG(A/G)AGATG reference, missense
rs1886792 -- 45,709,723(-) CAGCT(C/G/T)CACCA intron-variant
rs2031530 -- 45,706,619(+) ACCAG(A/G)AAAGA intron-variant
rs4941529 -- 45,710,563(+) CACAA(C/G)AAAAC intron-variant
rs6561247 -- 45,707,017(+) GCTTG(C/G)CTACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPERT Gene

Variant ID Type Subtype PubMed ID
dgv250e201 CNV Deletion 23290073

Variation tolerance for SPERT Gene

Residual Variation Intolerance Score: 61.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.69; 91.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPERT Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPERT Gene

Disorders for SPERT Gene

Relevant External Links for SPERT

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SPERT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPERT Gene

Publications for SPERT Gene

  1. A genome-wide scan for signatures of recent selection in Holstein cattle. (PMID: 20096028) Qanbari S. … Simianer H. (Anim. Genet. 2010) 2 3 67
  2. Nurit, a novel leucine-zipper protein, expressed uniquely in the spermatid flower-like structure. (PMID: 12204287) Feige E. … Motro B. (Mech. Dev. 2002) 2 3
  3. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3

Products for SPERT Gene

Sources for SPERT Gene