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SPERT Gene

protein-coding   GIFtS: 41

GC13P045175
spermatid associated
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    

Aliases &
Descriptions
for SPERT

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
CBY2 1, 2, 3
FLJ35810 2
NURIT 1, 2
OTTHUMP00000018354 2
OTTHUMP00000018355 2
Descriptions
Protein chibby homolog 2 3
chibby homolog 2 2
novel leucine zipper testicular protein 2
spermatid associated 2
spermatid flower-like structure protein 2
testis specific leucine zipper protein nurit 2
testis-specific leucine zipper protein nurit 2
External Ids
HGNC: 307201
Entrez Gene: 2200822
UniProtKB: Q8NA613
Ensembl: ENSG000001740157
Search outside databases for aliases for SPERT gene

Summaries
for SPERT

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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   --

Genomic Location
for SPERT

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the SPERT gene  

Entrez Gene cytogenetic band: 13q14.12   Ensembl cytogenetic band:  13q14.12   HGNC cytogenetic band: 13q14.13

SPERT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P045175:     (about GC identifiers)

Start:
 45,174,447 bp from pter
End:
 45,186,694 bp from pter
Size:
 12,248 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000013.9  NT_024524.13  

Proteins
for SPERT

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: SPERT_HUMAN, Q8NA61 (See protein sequence)
Recommended Name: Spermatid-associated protein  
Size: 448 amino acids; 51570 Da
Subunit: Homodimer. Binds to NEK1 (By similarity)
Secondary accessions: A8K8I5 Q8NHV2
Alternative splicing: 2 isoforms:  Q8NA61-1   Q8NA61-2   

REFSEQ proteins: NP_689932.1  

ENSEMBL proteins: 
ENSP00000368249 ENSP00000309189 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Human Recombinant Proteins from Abnova (SPERT)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0016023 cytoplasmic membrane-bounded vesicle ISS12204287
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Antibodies for SPERT: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for SPERT

Assays for SPERT: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for SPERT

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q8NA61

UniProtKB/Swiss-Prot: SPERT_HUMAN, Q8NA61
Similarity: Belongs to the chibby family. SPERT subfamily

Gene Function
for SPERT

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (SPERT)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_152719

              Applied Biosystems Silencer® siRNAs for SPERT

              Sigma-Aldrich siRNA for SPERT  
                     Sigma-Aldrich shRNA for SPERT  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for SPERT
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_152719
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_152719
                                 untagged cDNA clone in CMV expression vector: NM_152719 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_152719

Pathways & Interactions
for SPERT

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


  --

Drugs & Compounds
for SPERT

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for SPERT
1 Novoseek chemical compound relationship for SPERT gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
leucine 69.56 6 8288566 (1), 10944455 (1), 12351190 (1), 9214634 (1) (see all 6)
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Transcripts
for SPERT

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (SPERT)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_152719

              Sigma-Aldrich siRNA for SPERT  
                     Sigma-Aldrich shRNA for SPERT  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_152719  

REFSEQ mRNAs for SPERT gene: 

NM_152719.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_152719  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_152719
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_152719
                                 untagged cDNA clone in CMV expression vector: NM_152719 

Additional cDNA sequence: 

AK093129.1 AK292350.1 BC027609.2 

2 DOTS entries:

DT.99999245  DT.75187731 

10 AceView cDNA sequences:

BC027609 BI825284 BI462342 AX747942 AK093129 AI611034 NM_152719 BG723733 
CD359993 BI465179 

highest scoring ESTs for SPERT:

AI611034 AK093129 BC027609 BG723733 BI462342 BI465179 BI825284 CD359993 NM_152719 AX747942 

Unigene Cluster for SPERT:

Spermatid associated
Hs.186363  [show with all ESTs]
Unigene Representative Sequence: AK292350


GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for SPERT

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1:                    -                     
SP2:              -     -                     
SP3:                                          

About this scheme

ECgene alternative splicing isoforms for SPERT

2 Ensembl transcripts including schematic representations:
ENST00000378966  ENST00000310521  

Expression
for SPERT

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

SPERT expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for SPERT

1 / 2

2 probe-sets matching SPERT gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

1553847_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

1553846_at2 U133Plus2 2 1.00 0.95 -- -- -- -- -- -- --
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: CCGGCCAGGA

SOURCE GeneReport for Unigene cluster: Hs.186363

Orthologs
for SPERT

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for SPERT gene from 5/6 species (see all 6 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 SPERT1   -- spermatid associated 83.82(n)
82.55(a)		 476922  XM_534125.2  XP_534125.2 
chimpanzee
(Pan troglodytes)		 SPERT1   -- spermatid associated 98.21(n)
97.97(a)		 742441  XM_001158682.1  XP_001158682.1 
cow
(Bos taurus)		 SPERT1   -- spermatid associated 87.99(n)
83.56(a)		 616053  XM_868017.2  XP_873110.1 
rat
(Rattus norvegicus)		 Spert1   -- spermatid associated 82.21(n)
79.37(a)		 498572  NM_001017506.1  NP_001017506.1 
mouse
(Mus musculus)		 Spert1, 5 145
 spermatid associated1, 5 80.46(n)1
78.17(a)1		 679261  NM_026457.11  NP_080733.11 
 AC1252055  AI4278885  (see all 12)
About this table        Species with no ortholog for SPERT

ENSEMBL Gene Tree for SPERT

Paralogs
for SPERT

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --

SNPs/Variants
for SPERT

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/88 NCBI SNPs in SPERT are shown (see all 88 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 84)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 13 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs15361821,2
A,C,F,H45173416(+) tagaaG/Accaac 1 -- ng514Minor allele frequency- A:0.11EU EA WA 420
rs15361811,2
A,C,F,H45172639(+) attcaT/Gagtag 1 -- ng518Minor allele frequency- G:0.44EU EA WA 836
rs15708821,2
A,C,F,H45173302(+) ATCAGT/GGCAGG 1 -- ng514Minor allele frequency- G:0.43EU EA WA 418
rs8725561,2
C,F,H,O45174504(+) GCCCTG/CAAAAA 1 -- ut51 ese37Minor allele frequency- C:0.11EU EA WA NA 558
rs19520981,2
A,C,F,H45174072(-) gaagcC/Aaatac 1 -- ng514Minor allele frequency- A:0.18EU EA WA 418
rs73172451,2
C,F,H45186146(+) TGCGGG/AAGATG 1 E/K mis1 ese37Minor allele frequency- A:0.34EU EA WA NA 554
rs79880941,2
A,H45172848(+) TCTTTG/AACCTC 1 -- ng51 tfbs34Minor allele frequency- A:0.00EU EA WA 420
rs79892761,2
A,H45172952(+) AGTATT/CGCCTT 1 -- ng514Minor allele frequency- C:0.00EU EA WA 416
rs79845531,2
F,H45174416(+) GACCAG/ACCAAG 1 -- ng514Minor allele frequency- A:0.01EU EA WA 418
rs79885651,2
A,H45173380(+) tgttaA/Tcaagc 1 -- ng514Minor allele frequency- T:0.00EU EA WA 420
About this table

HapMap Linkage Disequilibrium images for SPERT (up to first 250kb)

Disorders & Mutations
for SPERT

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

   --

Medical News
for SPERT

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for SPERT

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/12 PubMed articles for SPERT gene (see all 12 ):

Search for SPERT

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing SPERT

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 220082 HGNC: 30720 AceView: NURIT Ensembl:ENSG00000174015 euGenes: HUgn220082
ECgene: SPERT H-InvDB: SPERT

Other Databases showing SPERT

(According to HUGE)
About This Section

   --

Specialized Databases showing SPERT

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for SPERT

(Available from WIS Yeda, Salk, Tufts)
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  --

Services
for SPERT

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for SPERT:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for SPERT-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for SPERT Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for SPERT Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant Proteins (SPERT)
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 Search Tocris compounds for SPERT




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Search Novus for antibodies for SPERT

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