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SPEN Gene

protein-coding GIFtS: 57

GC01P016047

spen homolog, transcriptional regulator (Drosophila)
(Previous names: SPEN homolog, transcriptional regulator (Drosophila) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
KIAA0929 ^¹, ², ³
MINT ^¹, ², ³
OTT ^⁵
OTTHUMP00000010982 ^²
OTTHUMP00000044600 ^²
RBM15 ^⁵
RBM15C ^¹, ²
RP1-134O19.1 ^²
SHARP ^¹, ², ³

Descriptions
Msx2 interacting nuclear target (MINT) homolog ^²
SMART/HDAC1 associated repressor protein ^²
SMART/HDAC1-associated repressor protein ^³
SPEN homolog ^³
nuclear receptor transcription cofactor ^²
spen homolog, transcriptional regulator ^²
spen homolog, transcriptional regulator (Drosophila) ^¹, ²

External Ids
HGNC: 17575¹
Entrez Gene: 23013²
UniProtKB: Q96T58³
Ensembl: ENSG00000065526⁷

Search outside databases for aliases for SPEN gene

Previous GC identifer: GC01P015920

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for SPEN:

This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by

this gene product can occur through interactions with other repressors, by the recruitment of

proteins involved in histone deacetylation, or through sequestration of transcriptional

activators. The product of this gene contains a carboxy-terminal domain that permits binding to

other corepressor proteins. This domain also permits interaction with members of the NuRD complex,

a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this

repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA

coactivator; this binding can modulate the activity of both liganded and nonliganded steroid

receptors. [provided by RefSeq]

UniProtKB/Swiss-Prot: MINT_HUMAN, Q96T58

Function: Essential corepressor protein, which probably regulates different key pathways such as

the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which

prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation

activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone

B-cells. Probably represses transcription via the recruitment of large complexes containing

histone deacetylase proteins. May bind both to DNA and RNA

Gene Wiki entry for SPEN

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SPEN gene

Entrez Gene cytogenetic band: 1p36.33-p36.11 Ensembl cytogenetic band: 1p36.21 HGNC cytogenetic band: 1p36

SPEN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P016047: (about GC identifiers)

Start:	16,046,946 bp from pter
End:	16,139,537 bp from pter
Size:	92,592 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_004873.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MINT_HUMAN, Q96T58 (See protein sequence)

Recommended Name: Msx2-interacting protein

Size: 3664 amino acids; 402248 Da

Subunit: Interacts with MSX2 (By similarity). Interacts with NCOR2, HDAC1, HDAC2, RBBP4, MBD3 and

MTA1L1. Interacts with RBPSUH; this interaction may prevent the interaction between RBPSUH and

NOTCH1. Interacts with the nuclear receptors RAR and PPARD. Interacts with RAR in absence of

ligand. Bind to the steroid receptor RNA coactivator SRA. Interacts with Epstein-Barr virus

BSFL2/BMLF1

Subcellular location: Nucleus. Note=Associates with chromatin

PDB structures from and Proteopedia :

1OW1 (3D)

Secondary accessions: Q9H9A8 Q9NWH5 Q9UQ01 Q9Y556

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_055816.2

ENSEMBL proteins:

ENSP00000364906 ENSP00000364912

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (SPEN)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

About this table

Antibodies for SPEN:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for SPEN
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (SPEN), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (SPEN)
	Novus Biologicals Antibodies for SPEN

Assays for SPEN:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q96T58

ProtoNet protein and cluster: Q96T58

2 Blocks protein families:

IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

IPB012921 SPOC

UniProtKB/Swiss-Prot: MINT_HUMAN, Q96T58

Domain: The RID domain mediates the interaction with nuclear receptors (By similarity)

Domain: The SPOC domain, which mediates the interaction with NCOR2, is essential for the repressive

activity

Similarity: Belongs to the RRM Spen family

Similarity: Contains 1 RID (receptor interacting) domain

Similarity: Contains 4 RRM (RNA recognition motif) domains

Similarity: Contains 1 SPOC domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SPEN)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SPEN)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015001

Applied Biosystems Silencer® siRNAs for SPEN

Sigma-Aldrich siRNA for SPEN

Sigma-Aldrich shRNA for SPEN

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_015001
Myc/DDK tagged cDNA clone in CMV expression vector: NM_015001
untagged cDNA clone in CMV expression vector: NM_015001

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_015001

UniProtKB/Swiss-Prot: MINT_HUMAN, Q96T58

Function: Essential corepressor protein, which probably regulates different key pathways such as

the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which

prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation

activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone

B-cells. Probably represses transcription via the recruitment of large complexes containing

histone deacetylase proteins. May bind both to DNA and RNA

Induction: By hormone 17-beta-estradiol (E2)

12 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Spen):

	behavior/neurological	digestive/alimentary	endocrine/exocrine gland	growth/size
hematopoietic system	immune system	lethality-prenatal/perinatal	life span-post-weaning/aging	liver/biliary system
nervous system	skin/coat/nails

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003697	single-stranded DNA binding	IEA	--
GO:0003700	transcription factor activity	IEA	--
GO:0003714	transcription corepressor activity	IEA	--
GO:0003723	RNA binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for SPEN (Your Favorite Gene powered by Ingenuity)

Estrogen Receptor Signaling

GeneDecks SPEN for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for SPEN

5/16 Interacting proteins for SPEN (Q96T58¹ ENSP00000364912³) via UniProtKB, MINT, and/or STRING (see all 16 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CRK	P46108¹	EBI-765739, EBI-886
GRB2	P62993¹	EBI-765739, EBI-401755
NCK1	P16333¹	EBI-765739, EBI-389883
PIK3R1	P27986¹	EBI-765739, EBI-79464
PLCG1	P19174¹	EBI-765739, EBI-79387

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006357	regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0007219	Notch signaling pathway	IEA	--
GO:0045892	negative regulation of transcription, DNA-dependent	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for SPEN

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SPEN)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SPEN)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015001

Sigma-Aldrich siRNA for SPEN

Sigma-Aldrich shRNA for SPEN

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_015001

REFSEQ mRNAs for SPEN gene:

NM_015001.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_015001

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015001
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_015001
                                 untagged cDNA clone in CMV expression vector: NM_015001

Additional cDNA sequence:

AB023146.1 AF085964.1 AF356524.1 AK000882.1 AK022949.1 AK092332.1 AK127577.1 AL096858.1

CR620882.1

11 DOTS entries:

DT.446133 DT.91754742 DT.97846453 DT.40208796 DT.100778078 DT.426835 DT.92064564 DT.86996218

DT.95173478 DT.95356844 DT.95137800

24/290 AceView cDNA sequences (see all 290 ):

BU631715 CD172437 AI668831 AW469387 BM832329 AI261236 AK000882 CA419912

AI693158 BE219154 AI538488 AL096858 BU631681 AK022949 AB023146 BF195793

AI221483 BM831808 BU624742 AI554308 BE931618 NM_015001 T87389 BX956403

highest scoring ESTs for SPEN:

AL096858 AA004363 AA096228 AA099616 AA171695 AA249191 AA262827 AA291162 AA295573 AA384953

Unigene Cluster for SPEN:

Spen homolog, transcriptional regulator (Drosophila)

Hs.558463 [show with all ESTs]

Unigene Representative Sequence: NM_015001

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SPEN (see all 7 )

ExUns:	1	^	2	^	3	^	4a	·	4b	·	4c	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18a	·	18b	^	19a	·	19b
SP1:													-		-
SP2:													-		-
SP3:
SP4:																																									-
SP5:													-		-

About this scheme

ECgene alternative splicing isoforms for SPEN

2 Ensembl transcripts including schematic representations:

ENST00000375753 ENST00000375759

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

SPEN expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SPEN

¹ / ² / ³

7 probe-sets matching SPEN gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32172_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AL096858	1.00	0.90	0.95	1
201996_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AL524033	0.60	1.00	0.82	1
201997_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_015001	0.60	1.00	0.82	1
201996_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201997_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1556058_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1556059_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GACTCGCAGA

SOURCE GeneReport for Unigene cluster: Hs.558463
UniProtKB/Swiss-Prot: MINT_HUMAN, Q96T58
Tissue specificity: Expressed at high level in brain, testis, spleen and thymus. Expressed at
intermediate level in kidney, liver, mammary gland and skin

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SPEN gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
cow (Bos taurus)	SPEN¹	--	spen homolog, transcriptional regulator (Drosophila)	87.67(n) 88.91(a)	513692 XM_591419.3 XP_591419.3
rat (Rattus norvegicus)	Spen¹	--	SPEN homolog, transcriptional regulator (Drosophila)	91.82(n) 96.86(a)	365981 XM_345315.3 XP_345316.3
mouse (Mus musculus)	Spen^{1, 5}	4⁵	SPEN homolog, transcriptional regulator (Drosophila)^{1, 5}	81.27(n)¹ 82.79(a)¹	56381¹ NM_019763.2¹ NP_062737.2¹ AB055980⁵ AF156529⁵ (see all 15)
chicken (Gallus gallus)	SPEN¹	--	spen homolog, transcriptional regulator (Drosophila)	70.99(n) 70.47(a)	419460 XM_417618.2 XP_417618.2
zebrafish (Danio rerio)	57050981²	--	--	77.3(n)	322667 57050981

About this table Species with no ortholog for SPEN

ENSEMBL Gene Tree for SPEN

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for SPEN gene

RBM15B² RBM15²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/403 NCBI SNPs in SPEN are shown (see all 403 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 110)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs848209^1,2	A,C,F,H,O	16128594(+)	`AGAACC/TAGCAG`	1	L/P	mis¹		17	EA NA EU WA	1274
	rs848208^1,2	A,C,F,H,O	16128231(+)	`GCCTGC/TAGATG`	1	A/V	mis¹ ese³		19	NS MN EU EA WA	1722
	rs848210^1,2	C,F,H,O	16132400(+)	`AATCCG/AACCAA`	1	D/N	mis¹ ese³		13	MN EU EA WA	1440
	rs6668183^1,2	A,C,F,H	16046401(+)	`TAGGGC/GACAGG`	1	--	ng5¹		6	EU EA WA MN	1666
	rs848215^1,2	A,C,F,H	16139734(+)	`TGTCAC/TGGACA`	1	--	ng3¹		11	EU EA WA NA	888
	rs12095818^1,2	C,F,H	16129411(+)	`AGAGAT/GAGCCT`	1	E/D	mis¹		4	EU EA WA	406
	rs698889^1,2	A,C,F	16139627(-)	`GGGGAT/GCAAAA`	1	--	ng3¹		3	MN EA	364
	rs698890^1,2	A,C,F	16139958(-)	`CCCAGC/GAGGCC`	1	--	ng3¹		3	MN EA NA	228
	rs1045264^1,2	H	16132595(+)	`CCAAAG/TCATCT`	1	A/S	mis¹ ese³		3	EA WA	274
	rs9725423^1,2	H	16137801(+)	`TCAGGT/GGGAGA`	1	G/V	mis¹		4	EU EA WA	416

About this table

HapMap Linkage Disequilibrium images for SPEN (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 606077

1 Novoseek disease relationship for SPEN gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	0.00	2	17234755 (1), 15824732 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/29 PubMed articles for SPEN gene (see all 29 ):

Sharp, an inducible cofactor that integrates nuclear receptor repression and activation. (PubMed id 11331609)^{1, 2, 3, 4} Shi Y....Evans R.M. (2001)
A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling. (PubMed id 12897056)^{1, 3, 4} Ariyoshi M. and Schwabe J.W.R. (2003)
The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling. (PubMed id 11867749)^{1, 3, 4} Shi Y.... Evans R.M. (2002)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway. (PubMed id 12374742)^{3, 4} Oswald F....Schmid R.M. (2002)
Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)^{3, 4} Nagase T....Ohara O. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 23013	HGNC: 17575	AceView: SHARP	Ensembl:ENSG00000065526	euGenes: HUgn23013
ECgene: SPEN	H-InvDB: SPEN

(According to HUGE)
About This Section

HUGE: KIAA0929

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for SPEN	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for SPEN
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for SPEN:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SPEN-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SPEN		Antibodies for SPEN
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for SPEN		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (SPEN)
	Antibodies (SPEN)

Search OriGene for SPEN

Search Tocris compounds for SPEN

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for SPEN

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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SPEN Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for SPEN

Summaries
for SPEN

Genomic Location
for SPEN

Proteins
for SPEN

Protein Domains/
Families
for SPEN

Gene Function
for SPEN

Pathways & Interactions
for SPEN

Drugs & Compounds
for SPEN

Transcripts
for SPEN

Expression
for SPEN

Orthologs
for SPEN

Paralogs
for SPEN

SNPs/Variants
for SPEN

Disorders & Mutations
for SPEN

Medical News
for SPEN

Publications
for SPEN

Search for SPEN

Genome Databases showing SPEN

Other Databases showing SPEN

Specialized Databases showing SPEN

Licensable Technologies
for SPEN

Services
for SPEN

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SPEN Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor SPEN

Summariesfor SPEN

Genomic Locationfor SPEN

Proteinsfor SPEN

Protein Domains/Familiesfor SPEN

Gene Functionfor SPEN

Pathways & Interactionsfor SPEN

Drugs & Compoundsfor SPEN

Transcriptsfor SPEN

Expression for SPEN

Orthologsfor SPEN

Paralogsfor SPEN

SNPs/Variantsfor SPEN

Disorders & Mutationsfor SPEN

Medical Newsfor SPEN

Publicationsfor SPEN

Search for SPEN

Genome Databases showing SPEN

Other Databases showing SPEN

Specialized Databases showing SPEN

Licensable Technologiesfor SPEN

Servicesfor SPEN

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SPEN

Summaries
for SPEN

Genomic Location
for SPEN

Proteins
for SPEN

Protein Domains/
Families
for SPEN

Gene Function
for SPEN

Pathways & Interactions
for SPEN

Drugs & Compounds
for SPEN

Transcripts
for SPEN

Expression
for SPEN

Orthologs
for SPEN

Paralogs
for SPEN

SNPs/Variants
for SPEN

Disorders & Mutations
for SPEN

Medical News
for SPEN

Publications
for SPEN

Licensable Technologies
for SPEN

Services
for SPEN