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Aliases for SPEM2 Gene

Aliases for SPEM2 Gene

  • SPEM Family Member 2 2 3
  • C17orf74 3 4 5
  • Chromosome 17 Open Reading Frame 74 2 5
  • Uncharacterized Protein C17orf74 3

External Ids for SPEM2 Gene

Previous HGNC Symbols for SPEM2 Gene

  • C17orf74

Summaries for SPEM2 Gene

GeneCards Summary for SPEM2 Gene

SPEM2 (SPEM Family Member 2) is a Protein Coding gene.

Additional gene information for SPEM2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPEM2 Gene

Genomics for SPEM2 Gene

Regulatory Elements for SPEM2 Gene

Enhancers for SPEM2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H007474 1.8 FANTOM5 ENCODE dbSUPER 11.5 +55.7 55709 12 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC ZFP41 SSRP1 DVL2 PFAS SNORD10 POLR2A SNORA48 CTC1 KCTD11 NEURL4 CHRNB1 CNTROB
GH17H007712 0.7 FANTOM5 29.3 +287.5 287454 0 MXI1 RFX1 BMI1 GLIS2 MYNN GLIS1 ZNF341 EZH2 SPEM1 TMEM95 SPEM2 YBX2 DLG4 SLC35G6 CNTROB ELP5 GC17M007714 DNAH2
GH17H007465 1.3 Ensembl ENCODE dbSUPER 11.4 +42.1 42147 2 HDAC1 ESRRA ZNF175 BCL11B YY1 HIC1 CTBP1 NCOR1 RCOR1 NR2F6 CHRNB1 FGF11 TMEM102 SPEM2 SPEM1 TNFSF12-TNFSF13 TNFSF12 TMEM256 NLGN2 PLSCR3
GH17H007454 1.2 ENCODE dbSUPER 11.4 +31.1 31100 2 HDGF PKNOX1 ATF1 SIN3A FEZF1 YY1 ETS1 ZNF766 GLIS2 ELK1 CHRNB1 FGF11 SPEM2 SPEM1 TNFSF12-TNFSF13 TNFSF12 TMEM256 NLGN2 PLSCR3 ACAP1
GH17H007401 1.1 ENCODE 11.8 -20.8 -20756 4 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF143 ENSG00000262089 EIF4A1 SNORD10 SPEM2 CNTROB POLR2A CHRNB1 TP53 DVL2 ACAP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPEM2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPEM2 Gene

Chromosome:
17
Start:
7,424,881 bp from pter
End:
7,427,568 bp from pter
Size:
2,688 bases
Orientation:
Plus strand

Genomic View for SPEM2 Gene

Genes around SPEM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPEM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPEM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPEM2 Gene

Proteins for SPEM2 Gene

  • Protein details for SPEM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0P670-CQ074_HUMAN
    Recommended name:
    Uncharacterized protein C17orf74
    Protein Accession:
    Q0P670

    Protein attributes for SPEM2 Gene

    Size:
    501 amino acids
    Molecular mass:
    57131 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPEM2 Gene

Post-translational modifications for SPEM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPEM2 Gene

No data available for DME Specific Peptides for SPEM2 Gene

Domains & Families for SPEM2 Gene

Gene Families for SPEM2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SPEM2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPEM2: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SPEM2 Gene

Function for SPEM2 Gene

genes like me logo Genes that share phenotypes with SPEM2: view

Animal Model Products

miRNA for SPEM2 Gene

miRTarBase miRNAs that target SPEM2

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPEM2 Gene

Localization for SPEM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPEM2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPEM2 gene
Compartment Confidence
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SPEM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SPEM2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SPEM2 Gene

Pathways & Interactions for SPEM2 Gene

SuperPathways for SPEM2 Gene

No Data Available

Interacting Proteins for SPEM2 Gene

Gene Ontology (GO) - Biological Process for SPEM2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SPEM2 Gene

Drugs & Compounds for SPEM2 Gene

No Compound Related Data Available

Transcripts for SPEM2 Gene

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPEM2 Gene

No ASD Table

Relevant External Links for SPEM2 Gene

GeneLoc Exon Structure for
SPEM2
ECgene alternative splicing isoforms for
SPEM2

Expression for SPEM2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPEM2 Gene:

SPEM2
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPEM2 Gene

Orthologs for SPEM2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPEM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C17H17orf74 33
  • 97.92 (n)
C17orf74 34
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C5H17orf74 33
  • 76.42 (n)
C17orf74 34
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC497938 33
  • 72.85 (n)
mouse
(Mus musculus)
Mammalia 4933402P03Rik 34 33
  • 72.79 (n)
OneToOne
Spem2 16
Species where no ortholog for SPEM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPEM2 Gene

ENSEMBL:
Gene Tree for SPEM2 (if available)
TreeFam:
Gene Tree for SPEM2 (if available)

Paralogs for SPEM2 Gene

No data available for Paralogs for SPEM2 Gene

Variants for SPEM2 Gene

Sequence variations from dbSNP and Humsavar for SPEM2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1001511596 -- 7,425,541(+) CACAT(G/T)GTGAC upstream-variant-2KB, utr-variant-5-prime
rs1001942494 -- 7,425,305(+) AAAAG(A/G)ACAAT upstream-variant-2KB, utr-variant-5-prime
rs1002372128 -- 7,424,422(+) CCAAC(A/C)TGCCC upstream-variant-2KB
rs1002545419 -- 7,424,038(+) TGAAT(C/T)TACTC upstream-variant-2KB
rs1003361594 -- 7,427,783(+) ATTCT(C/T)CCTGT intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SPEM2 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
esv3639869 CNV loss 21293372
nsv457659 CNV loss 19166990
nsv470575 CNV loss 18288195
nsv523672 CNV loss 19592680
nsv526176 CNV gain 19592680
nsv574322 CNV loss 21841781
nsv952118 CNV deletion 24416366

Variation tolerance for SPEM2 Gene

Residual Variation Intolerance Score: 85.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.71; 73.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPEM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPEM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPEM2 Gene

Disorders for SPEM2 Gene

Relevant External Links for SPEM2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPEM2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPEM2

No disorders were found for SPEM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPEM2 Gene

Publications for SPEM2 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  2. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60

Products for SPEM2 Gene

Sources for SPEM2 Gene

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