Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SPEF2 Gene

Aliases for SPEF2 Gene

  • Sperm Flagellar 2 2 3 5
  • Cancer/Testis Antigen 122 2 3
  • KPL2 3 4
  • Testis Tissue Sperm-Binding Protein Li 47a 3
  • Protein KPL2 4
  • KIAA1770 4
  • CT122 3

External Ids for SPEF2 Gene

Summaries for SPEF2 Gene

GeneCards Summary for SPEF2 Gene

SPEF2 (Sperm Flagellar 2) is a Protein Coding gene. GO annotations related to this gene include protein dimerization activity.

UniProtKB/Swiss-Prot for SPEF2 Gene

  • Required for correct axoneme development.

Gene Wiki entry for SPEF2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPEF2 Gene

Genomics for SPEF2 Gene

Regulatory Elements for SPEF2 Gene

Enhancers for SPEF2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SPEF2 on UCSC Golden Path with GeneCards custom track

Promoters for SPEF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SPEF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPEF2 Gene

Chromosome:
5
Start:
35,617,779 bp from pter
End:
35,814,611 bp from pter
Size:
196,833 bases
Orientation:
Plus strand

Genomic View for SPEF2 Gene

Genes around SPEF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPEF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPEF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPEF2 Gene

Proteins for SPEF2 Gene

  • Protein details for SPEF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C093-SPEF2_HUMAN
    Recommended name:
    Sperm flagellar protein 2
    Protein Accession:
    Q9C093
    Secondary Accessions:
    • Q2TAC9
    • Q96LL6
    • Q9H5C7
    • Q9H5Q7

    Protein attributes for SPEF2 Gene

    Size:
    1822 amino acids
    Molecular mass:
    209811 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15700.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SPEF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPEF2 Gene

Proteomics data for SPEF2 Gene at MOPED

Post-translational modifications for SPEF2 Gene

  • Ubiquitination at Lys 982
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SPEF2 Gene

Domains & Families for SPEF2 Gene

Protein Domains for SPEF2 Gene

Suggested Antigen Peptide Sequences for SPEF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9C093

UniProtKB/Swiss-Prot:

SPEF2_HUMAN :
  • Contains 1 CH (calponin-homology) domain.
Domain:
  • Contains 1 CH (calponin-homology) domain.
genes like me logo Genes that share domains with SPEF2: view

No data available for Gene Families for SPEF2 Gene

Function for SPEF2 Gene

Molecular function for SPEF2 Gene

UniProtKB/Swiss-Prot Function:
Required for correct axoneme development.
genes like me logo Genes that share phenotypes with SPEF2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPEF2 Gene

Localization for SPEF2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPEF2 Gene COMPARTMENTS Subcellular localization image for SPEF2 gene
Compartment Confidence
cytosol 3
golgi apparatus 3
cytoskeleton 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SPEF2 Gene

Pathways & Interactions for SPEF2 Gene

SuperPathways for SPEF2 Gene

No Data Available

Interacting Proteins for SPEF2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000348314%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000348314 Q9C093-SPEF2_HUMAN for SPEF2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SPEF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002520 immune system development IEA --
GO:0007283 spermatogenesis IEA --
GO:0009566 fertilization IEA --
GO:0010259 multicellular organism aging IEA --
GO:0060541 respiratory system development IEA --
genes like me logo Genes that share ontologies with SPEF2: view

No data available for Pathways by source and SIGNOR curated interactions for SPEF2 Gene

Drugs & Compounds for SPEF2 Gene

No Compound Related Data Available

Transcripts for SPEF2 Gene

Unigene Clusters for SPEF2 Gene

Sperm flagellar 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPEF2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1:
SP2:
SP3:
SP4: -
SP5: - -
SP6: -
SP7: - -
SP8: - -
SP9: -
SP10:

ExUns: 21 ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35
SP1:
SP2: - - - - - -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for SPEF2 Gene

GeneLoc Exon Structure for
SPEF2
ECgene alternative splicing isoforms for
SPEF2

Expression for SPEF2 Gene

mRNA expression in normal human tissues for SPEF2 Gene

Protein differential expression in normal tissues from HIPED for SPEF2 Gene

This gene is overexpressed in Fetal Brain (41.1), Platelet (17.2), and Fetal ovary (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPEF2 Gene



SOURCE GeneReport for Unigene cluster for SPEF2 Gene Hs.298863

genes like me logo Genes that share expression patterns with SPEF2: view

Protein tissue co-expression partners for SPEF2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SPEF2 Gene

Orthologs for SPEF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPEF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SPEF2 35
  • 83.68 (n)
  • 79.47 (a)
SPEF2 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPEF2 35
  • 86.99 (n)
  • 82.19 (a)
SPEF2 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spef2 35
  • 78.38 (n)
  • 71.5 (a)
Spef2 16
Spef2 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SPEF2 35
  • 98.86 (n)
  • 97.63 (a)
SPEF2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spef2 35
  • 78.58 (n)
  • 73.74 (a)
oppossum
(Monodelphis domestica)
Mammalia SPEF2 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 76 (a)
OneToMany
-- 36
  • 49 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
-- 36
  • 55 (a)
OneToMany
-- 36
  • 55 (a)
OneToMany
chicken
(Gallus gallus)
Aves SPEF2 35
  • 63.86 (n)
  • 54.06 (a)
SPEF2 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPEF2 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spef2 35
  • 59.41 (n)
  • 52.49 (a)
Str.19623 35
zebrafish
(Danio rerio)
Actinopterygii spef2 35
  • 52.54 (n)
  • 42.77 (a)
spef2 36
  • 39 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToOne
Species with no ortholog for SPEF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPEF2 Gene

ENSEMBL:
Gene Tree for SPEF2 (if available)
TreeFam:
Gene Tree for SPEF2 (if available)

Paralogs for SPEF2 Gene

Pseudogenes.org Pseudogenes for SPEF2 Gene

genes like me logo Genes that share paralogs with SPEF2: view

No data available for Paralogs for SPEF2 Gene

Variants for SPEF2 Gene

Sequence variations from dbSNP and Humsavar for SPEF2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs6897513 - 35,641,480(+) CACTT(A/C)ACCTT nc-transcript-variant, reference, missense, utr-variant-5-prime
rs34307272 - 35,641,489(+) TTCTG(A/G)GTGTG nc-transcript-variant, reference, missense, utr-variant-5-prime
rs16902381 - 35,659,137(+) AAACA(A/G)AATTT nc-transcript-variant, reference, missense
rs34852821 - 35,667,244(+) CTATC(A/G)AATGT nc-transcript-variant, reference, missense
rs34708521 - 35,670,201(+) TGCTA(A/G)ATACC nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SPEF2 Gene

Variant ID Type Subtype PubMed ID
nsv525477 CNV Loss 19592680
dgv6033n71 CNV Loss 21882294
esv2730067 CNV Deletion 23290073
esv2001300 CNV Deletion 18987734
esv2730068 CNV Deletion 23290073
esv2730069 CNV Deletion 23290073
esv2730070 CNV Deletion 23290073
esv270434 CNV Insertion 20981092
nsv509064 CNV Insertion 20534489
nsv515831 CNV Gain 19592680
esv2487237 CNV Insertion 19546169
nsv507244 CNV Insertion 20534489
esv26311 CNV Gain 19812545
esv2264320 CNV Deletion 18987734
esv2730071 CNV Deletion 23290073
esv2730072 CNV Deletion 23290073
esv1699889 CNV Insertion 17803354
esv1009459 CNV Insertion 20482838
esv1670180 CNV Insertion 17803354
nsv329452 CNV Insertion 16902084
nsv483069 CNV Gain 15286789
nsv4793 CNV Insertion 18451855

Variation tolerance for SPEF2 Gene

Residual Variation Intolerance Score: 98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.95; 95.98% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SPEF2 Gene

Disorders for SPEF2 Gene

Relevant External Links for SPEF2

Genetic Association Database (GAD)
SPEF2
Human Genome Epidemiology (HuGE) Navigator
SPEF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPEF2

No disorders were found for SPEF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPEF2 Gene

Publications for SPEF2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. Infertile Finnish Yorkshire boars carry a full-length LINE-1 retrotransposon within the KPL2 gene. (PMID: 17610085) Sironen A. … Thomsen B. (Mol. Genet. Genomics 2007) 2 3
  3. An intronic insertion in KPL2 results in aberrant splicing and causes the immotile short-tail sperm defect in the pig. (PMID: 16549801) Sironen A. … Vilkki J. (Proc. Natl. Acad. Sci. U.S.A. 2006) 2 3
  4. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PMID: 23648065) Low S.K. … Nakamura Y. (Cancer Sci. 2013) 3
  5. Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data. (PMID: 21244703) Wang J.H. … Oksenberg J.R. (Genome Med 2011) 3

Products for SPEF2 Gene

Sources for SPEF2 Gene

Content