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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPEF2 Gene

protein-coding   GIFtS: 49
GCID: GC05P035654

Sperm Flagellar 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sperm Flagellar 21 2     Sperm Flagellar Protein 22
Cancer/Testis Antigen 1221 2     KIAA17703
KPL22 3     Protein KPL23
CT1222     

External Ids:    HGNC: 262931   Entrez Gene: 799252   Ensembl: ENSG000001525827   OMIM: 6101725   UniProtKB: Q9C0933   

Export aliases for SPEF2 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SPEF2 Gene: 
SPEF2 (sperm flagellar 2) is a protein-coding gene. Diseases associated with SPEF2 include primary ciliary dyskinesia, and infertility. GO annotations related to this gene include nucleobase-containing compound kinase activity and protein dimerization activity.

UniProtKB/Swiss-Prot: SPEF2_HUMAN, Q9C093
Function: Required for correct axoneme development (By similarity)

Gene Wiki entry for SPEF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_006576.16  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPEF2 gene promoter:
         AhR   C/EBPbeta   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   MIF-1   FOXL1   Gfi-1   FOXC1   c-Myb   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPEF2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SPEF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPEF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p13.2   Ensembl cytogenetic band:  5p13.2   HGNC cytogenetic band: 5p13.2

SPEF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPEF2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P035654:  view genomic region     (about GC identifiers)

Start:
35,617,946 bp from pter      End:
35,814,713 bp from pter
Size:
196,768 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SPEF2_HUMAN, Q9C093 (See protein sequence)
Recommended Name: Sperm flagellar protein 2  
Size: 1822 amino acids; 209811 Da
Sequence caution: Sequence=BAB15700.1; Type=Erroneous initiation;
Secondary accessions: Q2TAC9 Q96LL6 Q9H5C7 Q9H5Q7
Alternative splicing: 4 isoforms:  Q9C093-1   Q9C093-2   Q9C093-3   Q9C093-4   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for SPEF2: NX_Q9C093

Explore proteomics data for SPEF2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9C093

  • SPEF2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SPEF2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_079143.3  NP_653323.1  

    ENSEMBL proteins: 
     ENSP00000282469   ENSP00000421593   ENSP00000348314   ENSP00000425448   ENSP00000426259  
     ENSP00000412125   ENSP00000421744   ENSP00000421062   ENSP00000422710   ENSP00000426624  
     ENSP00000423400   ENSP00000303843  

    Human Recombinant Protein Products for SPEF2: 
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    Novus Biologicals SPEF2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SPEF2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002177manchette IEA--
    GO:0005737cytoplasm ----
    GO:0005794Golgi apparatus IEA--
    GO:0097225sperm midpiece IEA--

    SPEF2 for ontologies           About GeneDecksing



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    Assay Products for SPEF2: 
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    Cloud-Clone Corp. ELISAs for SPEF2 
    Cloud-Clone Corp. CLIAs for SPEF2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR001715 CH-domain
     IPR027417 P-loop_NTPase
     IPR000850 Adenylate_kin
     IPR008906 HATC
     IPR010441 DUF1042

    Graphical View of Domain Structure for InterPro Entry Q9C093

    ProtoNet protein and cluster: Q9C093

    1 Blocks protein domain: IPB008906 HAT dimerisation

    UniProtKB/Swiss-Prot: SPEF2_HUMAN, Q9C093
    Similarity: Contains 1 CH (calponin-homology) domain


    SPEF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPEF2_HUMAN, Q9C093
    Function: Required for correct axoneme development (By similarity)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0019205nucleobase-containing compound kinase activity IEA--
    GO:0046983protein dimerization activity IEA--
         
    SPEF2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SPEF2:
     Cells with protrusions 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Spef2):
     craniofacial  immune system  mortality/aging  nervous system  reproductive system 
     respiratory system  skeleton 

    SPEF2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SPEF2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SPEF2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPEF2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPEF2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPEF2
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate SPEF2:
    hsa-miR-3163 hsa-miR-3688-3p hsa-miR-3146 hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidSPEF2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of SPEF2

    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPEF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPEF2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPEF2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPEF2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for SPEF2 (Q9C0933 ENSP000003483144) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APOA1P026473, ENSP000002368504I2D: score=1 STRING: ENSP00000236850
    IGHA1P018763, ENSP000003749894I2D: score=1 STRING: ENSP00000374989
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002520immune system development IEA--
    GO:0006139nucleobase-containing compound metabolic process IEA--
    GO:0007283spermatogenesis IEA--
    GO:0009566fertilization IEA--
    GO:0010259multicellular organismal aging IEA--

    SPEF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPEF2

    Search CenterWatch for drugs/clinical trials and news about SPEF2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SPEF2 gene (2 alternative transcripts): 
    NM_024867.3  NM_144722.3  

    Unigene Cluster for SPEF2:

    Sperm flagellar 2
    Hs.298863  [show with all ESTs]
    Unigene Representative Sequence: AL832607
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000282469(uc003jjn.1) ENST00000509059(uc003jjq.4) ENST00000356031(uc003jjo.3)
    ENST00000505847 ENST00000505088 ENST00000510777 ENST00000440995(uc003jjp.1)
    ENST00000502454 ENST00000503074 ENST00000504054 ENST00000508817 ENST00000506759
    ENST00000506526(uc003jjr.3) ENST00000513078 ENST00000303129
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPEF2
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate SPEF2:
    hsa-miR-3163 hsa-miR-3688-3p hsa-miR-3146 hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidSPEF2 3' UTR sequence
    Inhib. RNA
    Products:
         
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    OriGene clones in human, mouse for SPEF2 (see all 11)
    OriGene ORF clones in mouse, rat for SPEF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SPEF2 (NM_144722)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPEF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPEF2
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPEF2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPEF2

    Additional mRNA sequence: 

    AB051557.1 AK027230.1 AK058124.1 AK094564.1 AK097547.1 AK225586.1 AK225607.1 AL832607.1 
    BC016773.1 BC067761.1 BC110984.1 BX648691.1 EF553528.1 

    11 DOTS entries:

    DT.92015558  DT.100735435  DT.75136694  DT.100016377  DT.100016376  DT.101976363  DT.40276326  DT.100044242 
    DT.120799232  DT.91660533  DT.75127928 

    24/53 AceView cDNA sequences (see all 53):

    NM_144722 AK058124 AW243784 AK026817 AI559708 BP369614 AW516107 BQ576090 
    BQ023272 AB051557 NM_024867 AK097547 BX648691 BC016773 AW768842 BM975758 
    AI979232 BX642562 CA430816 BM804929 AW273539 AW299976 CA944963 AK094564 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for SPEF2 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                          -                                                                                 
    SP5:                                                                                                  -                 -                                       

    ExUns: 21 ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35
    SP1:                                                                                                      
    SP2:                          -     -     -     -     -     -                                             
    SP3:                          -                                                                           
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for SPEF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPEF2 expression in normal human tissues (normalized intensities)      SPEF2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SPEF2 Expression
    About this image


    SPEF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Epithelium (Respiratory System)    fully expand to see all 2 entries
             bronchial epithelial cells   
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...

    See SPEF2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPEF2

    SOURCE GeneReport for Unigene cluster: Hs.298863
        SABiosciences Custom PCR Arrays for SPEF2
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPEF2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPEF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SPEF2 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spef21 , 5 sperm flagellar 21, 5 78.4(n)1
    70.99(a)1
      15 (4.24 cM)5
    3202771  NM_177123.31  NP_796097.21 
     95781935 
    chicken
    (Gallus gallus)
    Aves SPEF21 sperm flagellar 2 63.31(n)
    53.67(a)
      427435  XM_003642976.1  XP_003643024.1 
    lizard
    (Anolis carolinensis)
    Reptilia SPEF26
    Uncharacterized protein
    69(a)
    1 ↔ 1
    GL343241.1(1702929-1757044)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.196232 Transcribed sequence with weak similarity to protein more 73.5(n)    BX781655.1 
    zebrafish
    (Danio rerio)
    Actinopterygii spef21 sperm flagellar 2 51.45(n)
    40.96(a)
      553375  NM_001128232.1  NP_001121704.1 


    ENSEMBL Gene Tree for SPEF2 (if available)
    TreeFam Gene Tree for SPEF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPEF2 gene

    SPEF2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SPEF2
    PGOHUM00000240517


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4233 SNPs in SPEF2 are shown (see all 4233)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs109412511,2
    C,F,A,H--35616001(+) gataaG/Attggc 2 -- us2k120Minor allele frequency- A:0.40NS EA WA NA CSA 2328
    rs1926857031,2
    --35616016(+) CATATA/GCAGAA 2 -- us2k10--------
    rs126579361,2
    C,F,A,H--35616027(+) gagtaG/Aagctg 2 -- us2k124Minor allele frequency- A:0.23NS EA NA WA CSA 2768
    rs1143425711,2
    F--35616052(+) CCACAT/CACACA 2 -- us2k11Minor allele frequency- C:0.01NA 120
    rs785797481,2
    F--35616115(+) AACTAC/TTAGAA 2 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1847207251,2
    --35616199(+) CAACTA/GAAACA 2 -- us2k10--------
    rs1889930951,2
    --35616236(+) AACTAA/GAAAGC 2 -- us2k10--------
    rs1820369161,2
    --35616260(+) ATGAAA/GCAATC 2 -- us2k10--------
    rs1849894631,2
    --35616279(+) GAAGAA/GACAAC 2 -- us2k10--------
    rs1442304311,2
    --35616631(+) TATGAA/CCACTA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SPEF2 (35617946 - 35814713 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/22 variations for SPEF2 (see all 22):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2264320CNV Deletion18987734
    esv2730068CNV Deletion23290073
    esv2730071CNV Deletion23290073
    esv2730069CNV Deletion23290073
    esv2730070CNV Deletion23290073
    esv2001300CNV Deletion18987734
    esv2730067CNV Deletion23290073
    esv2730072CNV Deletion23290073
    esv1699889CNV Insertion17803354
    nsv507244CNV Insertion20534489

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610172    OMIM disorders: --

    2 diseases for SPEF2:    About MalaCards
    primary ciliary dyskinesia    infertility

    1 disease from the University of Copenhagen DISEASES database for SPEF2:
    Primary ciliary dyskinesia

    SPEF2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SPEF2
    Human Genome Epidemiology (HuGE) Navigator: SPEF2 (2 documents)

    Export disorders for SPEF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPEF2 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with SPEF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. Modeling the cumulative genetic risk for multiple scl erosis from genome-wide association data. (PubMed id 21244703)1, 4 Wang J.H....Oksenberg J.R. (2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (2009)
    5. Infertile Finnish Yorkshire boars carry a full-length LINE-1 retrotransposon within the KPL2 gene. (PubMed id 17610085)1, 3 Sironen A....Thomsen B. (2007)
    6. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)1, 2 Denis N.J.... Figeys D. (2007)
    7. An intronic insertion in KPL2 results in aberrant spl icing and causes the immotile short-tail sperm defect in the pig. (PubMed id 16549801)1, 3 Sironen A....Vilkki J. (2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79925 HGNC: 26293 AceView: FLJ23577 Ensembl:ENSG00000152582 euGenes: HUgn79925
    ECgene: SPEF2 H-InvDB: SPEF2

    (According to HUGE)
    About This Section
    HUGE: KIAA1770

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPEF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SPEF2 gene:
    Search GeneIP for patents involving SPEF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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