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SPEF2 Gene

protein-coding   GIFtS: 50
GCID: GC05P035654

Sperm Flagellar 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sperm Flagellar 21 2     CT1222
KPL22 3 5     Sperm Flagellar Protein 22
Cancer/Testis Antigen 1221 2     Protein KPL23
KIAA17703 5     

External Ids:    HGNC: 262931   Entrez Gene: 799252   Ensembl: ENSG000001525827   OMIM: 6101725   UniProtKB: Q9C0933   

Export aliases for SPEF2 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SPEF2 Gene:
SPEF2 (sperm flagellar 2) is a protein-coding gene. GO annotations related to this gene include nucleobase-containing compound kinase activity and protein dimerization activity.

UniProtKB/Swiss-Prot: SPEF2_HUMAN, Q9C093
Function: Required for correct axoneme development (By similarity)

Gene Wiki entry for SPEF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_006576.17  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPEF2 gene promoter:
         AhR   C/EBPbeta   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   MIF-1   FOXL1   Gfi-1   FOXC1   c-Myb   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPEF2 promoter sequence
   Search Chromatin IP Primers for SPEF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPEF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p13.2   Ensembl cytogenetic band:  5p13.2   HGNC cytogenetic band: 5p13.2

SPEF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPEF2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P035654:  view genomic region     (about GC identifiers)

Start:
35,617,946 bp from pter      End:
35,814,713 bp from pter
Size:
196,768 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SPEF2_HUMAN, Q9C093 (See protein sequence)
Recommended Name: Sperm flagellar protein 2  
Size: 1822 amino acids; 209811 Da
Sequence caution: Sequence=BAB15700.1; Type=Erroneous initiation;
Secondary accessions: Q2TAC9 Q96LL6 Q9H5C7 Q9H5Q7
Alternative splicing: 4 isoforms:  Q9C093-1   Q9C093-2   Q9C093-3   Q9C093-4   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for SPEF2: NX_Q9C093

Explore proteomics data for SPEF2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys982
  • Modification sites at PhosphoSitePlus

  • See SPEF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_079143.3  NP_653323.1  

    ENSEMBL proteins: 
     ENSP00000282469   ENSP00000421593   ENSP00000348314   ENSP00000425448   ENSP00000426259  
     ENSP00000412125   ENSP00000421744   ENSP00000421062   ENSP00000422710   ENSP00000426624  
     ENSP00000423400   ENSP00000303843  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001715 CH-domain
     IPR027417 P-loop_NTPase
     IPR008906 HATC_dom_C
     IPR010441 DUF1042

    Graphical View of Domain Structure for InterPro Entry Q9C093

    ProtoNet protein and cluster: Q9C093

    1 Blocks protein domain: IPB008906 HAT dimerisation

    UniProtKB/Swiss-Prot: SPEF2_HUMAN, Q9C093
    Similarity: Contains 1 CH (calponin-homology) domain


    Find genes that share domains with SPEF2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPEF2_HUMAN, Q9C093
    Function: Required for correct axoneme development (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0005515protein binding ----
    GO:0046983protein dimerization activity IEA--
         
    Find genes that share ontologies with SPEF2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SPEF2:
     Cells with protrusions 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Spef2):
     craniofacial  immune system  mortality/aging  nervous system  reproductive system 
     respiratory system  skeleton 

    Find genes that share phenotypes with SPEF2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPEF2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPEF2
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    hsa-miR-3163 hsa-miR-3688-3p hsa-miR-3146 hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidSPEF2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    cytoskeleton2
    golgi apparatus2
    nucleus2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002177manchette IEA--
    GO:0005737cytoplasm ----
    GO:0005794Golgi apparatus IEA--
    GO:0097225sperm midpiece IEA--

    Find genes that share ontologies with SPEF2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPEF2
    Interactions:

        Search GeneGlobe Interaction Network for SPEF2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for SPEF2 (Q9C0933 ENSP000003483144) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APOA1P026473, ENSP000002368504I2D: score=1 STRING: ENSP00000236850
    IGHA1P018763, ENSP000003749894I2D: score=1 STRING: ENSP00000374989
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002520immune system development IEA--
    GO:0007283spermatogenesis IEA--
    GO:0009566fertilization IEA--
    GO:0010259multicellular organismal aging IEA--
    GO:0035082axoneme assembly IEA--

    Find genes that share ontologies with SPEF2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPEF2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SPEF2 gene (2 alternative transcripts): 
    NM_024867.3  NM_144722.3  

    Unigene Cluster for SPEF2:

    Sperm flagellar 2
    Hs.298863  [show with all ESTs]
    Unigene Representative Sequence: AL832607
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000282469(uc003jjn.1) ENST00000509059(uc003jjq.4) ENST00000356031(uc003jjo.3)
    ENST00000505847 ENST00000505088 ENST00000510777 ENST00000440995(uc003jjp.1)
    ENST00000502454 ENST00000503074 ENST00000504054 ENST00000508817 ENST00000506759
    ENST00000506526(uc003jjr.3) ENST00000513078 ENST00000303129
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate SPEF2:
    hsa-miR-3163 hsa-miR-3688-3p hsa-miR-3146 hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidSPEF2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): SPEF2 (NM_144722)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPEF2
      QuantiTect SYBR Green Assays in human, mouse, rat SPEF2
      QuantiFast Probe-based Assays in human, mouse, rat SPEF2

    Additional mRNA sequence: 

    AB051557.1 AK027230.1 AK058124.1 AK094564.1 AK097547.1 AK225586.1 AK225607.1 AL832607.1 
    BC016773.1 BC067761.1 BC110984.1 BX648691.1 EF553528.1 

    11 DOTS entries:

    DT.92015558  DT.100735435  DT.75136694  DT.100016377  DT.100016376  DT.101976363  DT.40276326  DT.100044242 
    DT.120799232  DT.91660533  DT.75127928 

    Selected AceView cDNA sequences (see all 53):

    AK058124 NM_144722 AI559708 AK026817 AW516107 BQ576090 AB051557 AW243784 
    NM_024867 BQ023272 BP369614 AK097547 AW768842 AI650342 BC016773 BM804929 
    AI277977 BC067761 BX642562 AW299976 CA944963 AK027230 BU685390 AK094564 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SPEF2 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                          -                                                                                 
    SP5:                                                                                                  -                 -                                       

    ExUns: 21 ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35
    SP1:                                                                                                      
    SP2:                          -     -     -     -     -     -                                             
    SP3:                          -                                                                           
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for SPEF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SPEF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SPEF2 Expression
    About this image

    SPEF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPEF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.298863
        Custom PCR Arrays for SPEF2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPEF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SPEF2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spef21 , 5 sperm flagellar 21, 5 78.38(n)1
    71.5(a)1
      15 (4.24 cM)5
    3202771  NM_177123.31  NP_796097.21 
     95781935 
    chicken
    (Gallus gallus)
    Aves SPEF21 sperm flagellar 2 63.86(n)
    54.06(a)
      427435  XM_003642976.2  XP_003643024.2 
    lizard
    (Anolis carolinensis)
    Reptilia SPEF26
    sperm flagellar 2
    69(a)
    1 ↔ 1
    GL343241.1(1702929-1757044)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.196232 Transcribed sequence with weak similarity to protein more 73.5(n)    BX781655.1 
    zebrafish
    (Danio rerio)
    Actinopterygii spef21 sperm flagellar 2 52.54(n)
    42.77(a)
      553375  NM_001128232.1  NP_001121704.1 


    ENSEMBL Gene Tree for SPEF2 (if available)
    TreeFam Gene Tree for SPEF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SPEF2 gene

    Find genes that share paralogs with SPEF2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SPEF2
    PGOHUM00000240517


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SPEF2 (see all 4233)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs109412511,2
    C,F,A,H--35616001(+) gataaG/Attggc 2 -- us2k120Minor allele frequency- A:0.40NS EA WA NA CSA 2328
    rs1926857031,2
    --35616016(+) CATATA/GCAGAA 2 -- us2k10--------
    rs126579361,2
    C,F,A,H--35616027(+) gagtaG/Aagctg 2 -- us2k124Minor allele frequency- A:0.23NS EA NA WA CSA 2768
    rs1143425711,2
    F--35616052(+) CCACAT/CACACA 2 -- us2k11Minor allele frequency- C:0.01NA 120
    rs785797481,2
    F--35616115(+) AACTAC/TTAGAA 2 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1847207251,2
    --35616199(+) CAACTA/GAAACA 2 -- us2k10--------
    rs1889930951,2
    --35616236(+) AACTAA/GAAAGC 2 -- us2k10--------
    rs1820369161,2
    --35616260(+) ATGAAA/GCAATC 2 -- us2k10--------
    rs1849894631,2
    --35616279(+) GAAGAA/GACAAC 2 -- us2k10--------
    rs1442304311,2
    --35616631(+) TATGAA/CCACTA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SPEF2 (35617946 - 35814713 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SPEF2 (see all 22):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2264320CNV Deletion18987734
    esv2730068CNV Deletion23290073
    esv2730071CNV Deletion23290073
    esv2730069CNV Deletion23290073
    esv2730070CNV Deletion23290073
    esv2001300CNV Deletion18987734
    esv2730067CNV Deletion23290073
    esv2730072CNV Deletion23290073
    esv1699889CNV Insertion17803354
    nsv507244CNV Insertion20534489

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610172    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for SPEF2:
    Primary ciliary dyskinesia

    Find genes that share disorders with SPEF2           About GenesLikeMe

    Genetic Association Database (GAD): SPEF2
    Human Genome Epidemiology (HuGE) Navigator: SPEF2 (2 documents)

    Export disorders for SPEF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SPEF2 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with SPEF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    2. Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data. (PubMed id 21244703)1, 4 Wang J.H....Oksenberg J.R. (Genome Med 2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    5. Infertile Finnish Yorkshire boars carry a full-length LINE-1 retrotransposon within the KPL2 gene. (PubMed id 17610085)1, 3 Sironen A....Thomsen B. (Mol. Genet. Genomics 2007)
    6. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)1, 2 Denis N.J.... Figeys D. (Proteomics 2007)
    7. An intronic insertion in KPL2 results in aberrant splicing and causes the immotile short-tail sperm defect in the pig. (PubMed id 16549801)1, 3 Sironen A....Vilkki J. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PubMed id 23648065)1 Low S.K....Nakamura Y. (Cancer Sci. 2013)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79925 HGNC: 26293 AceView: FLJ23577 Ensembl:ENSG00000152582 euGenes: HUgn79925
    ECgene: SPEF2 H-InvDB: SPEF2

    (According to HUGE)
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    HUGE: KIAA1770

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SPEF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SPEF2 gene:
    Search GeneIP for patents involving SPEF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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