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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SPEF2 Gene

protein-coding GIFtS: 50
GCID: GC05P035654

sperm flagellar 2

Explore 3 diseases affiliated with
SPEF2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sperm Flagellar 2¹ ²		Cancer/Testis Antigen 122²
KPL2¹ ² ³		Sperm Flagellar Protein 2²
CT122¹ ²		KIAA1770³
FLJ23577¹		Protein KPL2³

External Ids:	HGNC: 26293¹	Entrez Gene: 79925²	Ensembl: ENSG00000152582⁷	OMIM: 610172⁵	UniProtKB: Q9C093³

Export aliases for SPEF2 gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SPEF2_HUMAN, Q9C093

Function: Required for correct axoneme development (By similarity)

Gene Wiki entry for SPEF2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_006576.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SPEF2 gene promoter:
AhR C/EBPbeta POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) MIF-1 FOXL1 Gfi-1 FOXC1 c-Myb RSRFC4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SPEF2 promoter sequence

Search SABiosciences Chromatin IP Primers for SPEF2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPEF2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p13.2 Ensembl cytogenetic band: 5p13.2 HGNC cytogenetic band: 5p13.2

SPEF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPEF2 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P035654: view genomic region (about GC identifiers)

Start:	35,617,946 bp from pter	End:	35,814,713 bp from pter
Size:	196,768 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SPEF2_HUMAN, Q9C093 (See protein sequence)

Recommended Name: Sperm flagellar protein 2

Size: 1822 amino acids; 209811 Da

Sequence caution: Sequence=BAB15700.1; Type=Erroneous initiation;

Secondary accessions: Q2TAC9 Q96LL6 Q9H5C7 Q9H5Q7

Alternative splicing: 4 isoforms: Q9C093-1 Q9C093-2 Q9C093-3 Q9C093-4 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for SPEF2: NX_Q9C093

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9C093

SPEF2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_079143.3 NP_653323.1

ENSEMBL proteins:

ENSP00000282469 ENSP00000348314 ENSP00000421593 ENSP00000425448 ENSP00000426259

ENSP00000412125 ENSP00000421744 ENSP00000421062 ENSP00000422710 ENSP00000426624

ENSP00000423400 ENSP00000303843

Human Recombinant Protein Products:

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	GenScript Custom Purified and Recombinant Proteins Services for SPEF2
	Novus Biologicals SPEF2 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SPEF2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002177	manchette	IEA	--
GO:0005794	Golgi apparatus	IEA	--
GO:0097225	sperm midpiece	IEA	--

SPEF2 for ontologies About GeneDecksing

SPEF2 Antibody Products:

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	Novus Biologicals SPEF2 Antibodies
	Search for Antibodies for SPEF2 at Abcam
	Uscn Antibodies for SPEF2
	Search ThermoFisher Antibodies for SPEF2

Assay Products for SPEF2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	GenScript Custom Assay Services for SPEF2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SPEF2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SPEF2 for domains About GeneDecksing

4 InterPro domains/families:

IPR001715 CH-domain

IPR000850 Adenylate_kin

IPR008906 HATC

IPR010441 DUF1042

Graphical View of Domain Structure for InterPro Entry Q9C093

ProtoNet protein and cluster: Q9C093

1 Blocks protein family: IPB008906 HAT dimerisation

UniProtKB/Swiss-Prot: SPEF2_HUMAN, Q9C093

Similarity: Contains 1 CH (calponin-homology) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SPEF2_HUMAN, Q9C093

Function: Required for correct axoneme development (By similarity)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SPEF2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPEF2
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate SPEF2:
		hsa-miR-3163 hsa-miR-3688-3p hsa-miR-3146 hsa-miR-664
		SwitchGear 3'UTR luciferase reporter plasmid: SPEF2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPEF2 (see all 4) OriGene shRNA RFP: SPEF2 OriGene siRNA: SPEF2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPEF2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SPEF2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPEF2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPEF2 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): SPEF2 (NM_144722)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPEF2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPEF2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SPEF2
		Search LifeMap BioReagents cell lines for SPEF2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPEF2

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005524	ATP binding	IEA	--
GO:0019205	nucleobase-containing compound kinase activity	IEA	--
GO:0046983	protein dimerization activity	IEA	--

SPEF2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for SPEF2:

Cells with protrusions

Animal Models:
7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Spef2):

craniofacial	immune system	mortality/aging	nervous system	reproductive system
respiratory system	skeleton

SPEF2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SPEF2

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for SPEF2 (Q9C093³ ENSP00000348314⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APOA1	P02647³, ENSP00000236850⁴	I2D: score=1 STRING: ENSP00000236850
IGHA1	P01876³, ENSP00000374989⁴	I2D: score=1 STRING: ENSP00000374989

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006139	nucleobase-containing compound metabolic process	IEA	--

SPEF2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SPEF2
Search CenterWatch for drugs/clinical trials and news about SPEF2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SPEF2 gene (2 alternative transcripts):

NM_024867.3 NM_144722.3

Unigene Cluster for SPEF2:

Sperm flagellar 2

Hs.298863 [show with all ESTs]

Unigene Representative Sequence: AL832607

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000282469(uc003jjn.1) ENST00000356031(uc003jjo.3) ENST00000509059(uc003jjq.4)

ENST00000505847 ENST00000505088 ENST00000510777 ENST00000440995(uc003jjp.1)

ENST00000502454 ENST00000503074 ENST00000504054 ENST00000508817 ENST00000506759

ENST00000506526(uc003jjr.3) ENST00000513078 ENST00000303129

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SPEF2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPEF2
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate SPEF2:
		hsa-miR-3163 hsa-miR-3688-3p hsa-miR-3146 hsa-miR-664
		SwitchGear 3'UTR luciferase reporter plasmid: SPEF2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPEF2 (see all 4) OriGene shRNA RFP: SPEF2 OriGene siRNA: SPEF2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPEF2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPEF2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPEF2 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): SPEF2 (NM_144722)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPEF2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPEF2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPEF2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SPEF2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPEF2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPEF2

Additional cDNA sequence:

AB051557.1 AK027230.1 AK058124.1 AK094564.1 AK097547.1 AK225586.1 AK225607.1 AL832607.1

BC016773.1 BC067761.1 BC110984.1 BX648691.1 EF553528.1

11 DOTS entries:

DT.92015558 DT.100735435 DT.75136694 DT.100016377 DT.100016376 DT.101976363 DT.40276326 DT.100044242

DT.120799232 DT.91660533 DT.75127928

24/53 AceView cDNA sequences (see all 53):

NM_144722 BP369614 BQ023272 AW243784 AI559708 BQ576090 AK058124 AW516107

AB051557 NM_024867 AK026817 AW273539 BM804929 AI277977 AL832607 BU685390

CA944963 AK027230 AI979232 AK094564 BX648691 AI631784 BI561473 BI520300

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for SPEF2 (see all 10) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14a	·	14b	^	15	^	16	^	17	^	18	^	19	^	20	^
SP1:
SP2:
SP3:
SP4:																									-
SP5:																																	-						-

ExUns:	21	^	22	^	23a	·	23b	^	24a	·	24b	^	25	^	26	^	27	^	28	^	29	^	30	^	31	^	32	^	33	^	34	^	35
SP1:
SP2:									-		-		-		-		-		-
SP3:									-
SP4:
SP5:

ECgene alternative splicing isoforms for SPEF2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SPEF2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

SPEF2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SPEF2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPEF2

SOURCE GeneReport for Unigene cluster: Hs.298863

SABiosciences Custom PCR Arrays for SPEF2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPEF2 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPEF2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPEF2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SPEF2 gene from 6/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Spef2^{1 , 5}	sperm flagellar 2^{1, 5}	78.4(n)¹ 70.99(a)¹		15 (4.24 cM)⁵ 320277¹ NM_177123.3¹ NP_796097.2¹ 9578193⁵
chicken (Gallus gallus)	Aves	SPEF2¹	sperm flagellar 2	63.31(n) 53.67(a)		427435 XM_003642976.1 XP_003643024.1
lizard (Anolis carolinensis)	Reptilia	SPEF2⁶	--	69(a)	1 ↔ 1	GL343241.1(1728548-1736124)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.19623²	Transcribed sequence with weak similarity to protein more	73.5(n)		BX781655.1
zebrafish (Danio rerio)	Actinopterygii	spef2¹	sperm flagellar 2	51.45(n) 40.96(a)		553375 NM_001128232.1 NP_001121704.1
honey bee (Apis mellifera)	Insecta	--	--	16(a)	1 ↔ 1	GroupUn.855(18806-34737)

ENSEMBL Gene Tree for SPEF2 (if available)
TreeFam Gene Tree for SPEF2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SPEF2 gene

SPEF2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for SPEF2
PGOHUM00000240517

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs10941251^1,2	C,F,A,H,	--	35616001(+)	`GATAAG/ATTGGC`	2	--	us2k¹		20		NS EA WA NA CSA	2328
rs192685703^1,2		--	35616016(+)	`CATATA/GCAGAA`	2	--	us2k¹		0	--	--	--	--
rs12657936^1,2	C,F,A,H,	--	35616027(+)	`GAGTAG/AAGCTG`	2	--	us2k¹		24		NS EA NA WA CSA	2768
rs114342571^1,2		--	35616052(+)	`CCACAT/CACACA`	2	--	us2k¹		1		NA	120
rs78579748^1,2		--	35616115(+)	`AACTAC/TTAGAA`	2	--	us2k¹		1		NA	120
rs184720725^1,2		--	35616199(+)	`CAACTA/GAAACA`	2	--	us2k¹		0	--	--	--	--
rs188993095^1,2		--	35616236(+)	`AACTAA/GAAAGC`	2	--	us2k¹		0	--	--	--	--
rs182036916^1,2		--	35616260(+)	`ATGAAA/GCAATC`	2	--	us2k¹		0	--	--	--	--
rs184989463^1,2		--	35616279(+)	`GAAGAA/GACAAC`	2	--	us2k¹		0	--	--	--	--
rs144230431^1,2		--	35616631(+)	`TATGAA/CCACTA`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SPEF2 (35617946 - 35814713 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for SPEF2
4 CNVs: 51689 36410 69054 0062
2 Indels: 99111 40750

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPEF2

DNA2.0 Custom Variant and Variant Library Synthesis for SPEF2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SPEF2 for disorders           About GeneDecksing

OMIM gene information: 610172    OMIM disorders: --

3 diseases for SPEF2:    About MalaCards

ciliary dyskinesia primary ciliary dyskinesia infertility

1 disease from the University of Copenhagen DISEASES database for SPEF2:

Primary ciliary dyskinesia

Human Genome Epidemiology (HuGE) Navigator: SPEF2 (2 documents)

Export disorders for SPEF2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SPEF2 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with SPEF2)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)^{1, 2, 3} Nagase T.... Ohara O. (2000)
Infertile Finnish Yorkshire boars carry a full-length LINE-1 retrotransposon within the KPL2 gene. (PubMed id 17610085)^{1, 3} Sironen A....Thomsen B. (2007)
An intronic insertion in KPL2 results in aberrant spl icing and causes the immotile short-tail sperm defect in the pig. (PubMed id 16549801)^{1, 3} Sironen A....Vilkki J. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Modeling the cumulative genetic risk for multiple scl erosis from genome-wide association data. (PubMed id 21244703)¹ Wang J.H....Oksenberg J.R. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)¹ Trynka G....Wijmenga C. (2009)
Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)² Denis N.J.... Figeys D. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

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Aliases
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Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 79925	HGNC: 26293	AceView: FLJ23577	Ensembl:ENSG00000152582	euGenes: HUgn79925
ECgene: SPEF2	H-InvDB: SPEF2

(According to HUGE)
About This Section

HUGE: KIAA1770

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SPEF2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SPEF2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SPEF2 gene:
Search GeneIP for patents involving SPEF2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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sperm flagellar 2

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for SPEF2 gene

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for SPEF2 gene

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for SPEF2 gene

Pathways & Interactions
for SPEF2 gene

Drugs & Compounds
for SPEF2 gene

Transcripts
for SPEF2 gene

Expression
for SPEF2 gene

Orthologs
for SPEF2 gene

Paralogs
for SPEF2 gene

Genomic Variants
for SPEF2 gene

Disorders / Diseases
for SPEF2 gene

Publications
for SPEF2 gene

Intellectual Property
for SPEF2 gene

Products
for SPEF2 gene