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Aliases for SPEF1 Gene

Aliases for SPEF1 Gene

  • Sperm Flagellar 1 2 3
  • C20orf28 3 4 6
  • Calponin-Homology And Microtubule-Associated Protein 3
  • Chromosome 20 Open Reading Frame 28 2
  • Sperm Flagellar Protein 1 3
  • SPEF1A 3
  • CLAMP, 6
  • CLAMP 3

External Ids for SPEF1 Gene

Previous Symbols for SPEF1 Gene

  • C20orf28

Summaries for SPEF1 Gene

GeneCards Summary for SPEF1 Gene

SPEF1 (Sperm Flagellar 1) is a Protein Coding gene.

Gene Wiki entry for SPEF1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPEF1 Gene

Genomics for SPEF1 Gene

Genomic Location for SPEF1 Gene

Start:
3,777,504 bp from pter
End:
3,781,466 bp from pter
Size:
3,963 bases
Orientation:
Minus strand

Genomic View for SPEF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPEF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPEF1 Gene

Regulatory Elements for SPEF1 Gene

Proteins for SPEF1 Gene

  • Protein details for SPEF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4P9-SPEF1_HUMAN
    Recommended name:
    Sperm flagellar protein 1
    Protein Accession:
    Q9Y4P9
    Secondary Accessions:
    • A5YM71
    • D3DVY0
    • Q5JX78

    Protein attributes for SPEF1 Gene

    Size:
    236 amino acids
    Molecular mass:
    26987 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SPEF1 Gene

    Alternative splice isoforms for SPEF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPEF1 Gene

Proteomics data for SPEF1 Gene at MOPED

Post-translational modifications for SPEF1 Gene

No Post-translational modifications

Other Protein References for SPEF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPEF1 Gene

Domains for SPEF1 Gene

Protein Domains for SPEF1 Gene

genes like me logo Genes that share domains with SPEF1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SPEF1 Gene

Function for SPEF1 Gene

Gene Ontology (GO) - Molecular Function for SPEF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SPEF1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SPEF1 Gene

Localization for SPEF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPEF1 Gene

Cytoplasm. Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, cilium axoneme. Note=Present in the tails of developing and epididymal sperm, internal to the fibrous sheath and around the outer dense fibers of the sperm flagellum. Also found at the apical tip of cilia (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPEF1 Gene COMPARTMENTS Subcellular localization image for SPEF1 gene
Compartment Confidence
cytoskeleton 3
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for SPEF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm --
GO:0005856 cytoskeleton IEA --
GO:0005930 axoneme ISS --
GO:0031514 motile cilium IEA --
genes like me logo Genes that share ontologies with SPEF1: view

Pathways for SPEF1 Gene

SuperPathways for SPEF1 Gene

No Data Available

Interacting Proteins for SPEF1 Gene

Gene Ontology (GO) - Biological Process for SPEF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SPEF1: view

No data available for Pathways by source for SPEF1 Gene

Transcripts for SPEF1 Gene

mRNA/cDNA for SPEF1 Gene

Unigene Clusters for SPEF1 Gene

Sperm flagellar 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPEF1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2: -
SP3:
SP4:

Relevant External Links for SPEF1 Gene

GeneLoc Exon Structure for
SPEF1
ECgene alternative splicing isoforms for
SPEF1

Expression for SPEF1 Gene

mRNA expression in normal human tissues for SPEF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPEF1 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (9.3), Brain - Caudate (basal ganglia) (7.8), Brain - Nucleus accumbens (basal ganglia) (7.5), and Testis (4.4).

SOURCE GeneReport for Unigene cluster for SPEF1 Gene Hs.72620

genes like me logo Genes that share expressions with SPEF1: view

Orthologs for SPEF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPEF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPEF1 36
  • 99.29 (n)
  • 99.58 (a)
SPEF1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPEF1 36
  • 88.98 (n)
  • 91.1 (a)
SPEF1 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPEF1 36
  • 89.27 (n)
  • 90.68 (a)
SPEF1 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spef1 36
  • 85.61 (n)
  • 88.89 (a)
Spef1 16
Spef1 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPEF1 37
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spef1 36
  • 85.69 (n)
  • 87.98 (a)
chicken
(Gallus gallus)
Aves SPEF1 37
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPEF1 37
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spef1 36
  • 62.03 (n)
  • 60.54 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 36
SPEF1 37
  • 44 (a)
OneToOne
zgc:66426 36
  • 51.6 (n)
  • 46.12 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008402 36
  • 58.16 (n)
  • 40.82 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12395 37
  • 23 (a)
OneToMany
CG16719 37
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 46 (a)
OneToOne
Species with no ortholog for SPEF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPEF1 Gene

ENSEMBL:
Gene Tree for SPEF1 (if available)
TreeFam:
Gene Tree for SPEF1 (if available)

Paralogs for SPEF1 Gene

No data available for Paralogs for SPEF1 Gene

Variants for SPEF1 Gene

Sequence variations from dbSNP and Humsavar for SPEF1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs579111 -- 3,783,225(-) CCAGC(A/G)GTTCC upstream-variant-2KB
rs910654 -- 3,777,779(-) ATCCA(C/G)GCTAG utr-variant-3-prime
rs1968648 -- 3,782,702(-) GACGA(A/G)TTACT upstream-variant-2KB
rs1968649 -- 3,782,185(-) gaaac(A/C)gtgtt upstream-variant-2KB
rs2017118 -- 3,782,383(-) tcttt(C/T)ttttt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SPEF1 Gene

Variant ID Type Subtype PubMed ID
nsv833899 CNV Loss 17160897
nsv912617 CNV Loss 21882294
nsv828673 CNV Gain 20364138
nsv912618 CNV Loss 21882294
dgv4522n71 CNV Loss 21882294
nsv912621 CNV Loss 21882294

Relevant External Links for SPEF1 Gene

HapMap Linkage Disequilibrium report
SPEF1

Disorders for SPEF1 Gene

No disorders were found for SPEF1 Gene.

No data available for UniProtKB/Swiss-Prot for SPEF1 Gene

Publications for SPEF1 Gene

  1. Spef1, a conserved novel testis protein found in mouse sperm flagella. (PMID: 15979255) Chan S.W. … Kalitsis P. (Gene 2005) 2 3 4
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SPEF1 Gene

Sources for SPEF1 Gene

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