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Aliases for SPECC1L-ADORA2A Gene

Subcategory (RNA class) for SPECC1L-ADORA2A Gene


Quality Score for this RNA gene is


Aliases for SPECC1L-ADORA2A Gene

  • SPECC1L-ADORA2A Readthrough (NMD Candidate) 2 3
  • ADORA2A 4
  • ADORA2 4

External Ids for SPECC1L-ADORA2A Gene

Previous GeneCards Identifiers for SPECC1L-ADORA2A Gene

  • GC22U900941
  • GC22P024740

Summaries for SPECC1L-ADORA2A Gene

Entrez Gene Summary for SPECC1L-ADORA2A Gene

  • This locus represents naturally occurring readthrough transcription between the neighboring SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) genes on chromosome 22. The readthrough transcript is a candidate for nonsense-mediated mRNA decay (NMD) and is unlikely to produce a protein product. [provided by RefSeq, Jun 2013]

GeneCards Summary for SPECC1L-ADORA2A Gene

SPECC1L-ADORA2A (SPECC1L-ADORA2A Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the ncRNA class. An important paralog of this gene is SMTNL2.

UniProtKB/Swiss-Prot for SPECC1L-ADORA2A Gene

  • Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPECC1L-ADORA2A Gene

Genomics for SPECC1L-ADORA2A Gene

Genomic Location for SPECC1L-ADORA2A Gene

24,270,817 bp from pter
24,442,360 bp from pter
171,544 bases
Plus strand

Genomic View for SPECC1L-ADORA2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPECC1L-ADORA2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPECC1L-ADORA2A Gene

No data available for Regulatory Elements for SPECC1L-ADORA2A Gene

Proteins for SPECC1L-ADORA2A Gene

  • Protein details for SPECC1L-ADORA2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adenosine receptor A2a
    Protein Accession:
    Secondary Accessions:
    • B2R7E0

    Protein attributes for SPECC1L-ADORA2A Gene

    412 amino acids
    Molecular mass:
    44707 Da
    Quaternary structure:
    • Interacts (via cytoplasmic C-terminal domain) with USP4; the interaction is direct. May interact with DRD4.
    • Sequence=AAA58356.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SPECC1L-ADORA2A Gene

neXtProt entry for SPECC1L-ADORA2A Gene

Proteomics data for SPECC1L-ADORA2A Gene at MOPED

Post-translational modifications for SPECC1L-ADORA2A Gene

  • Ubiquitinated. Deubiquitinated by USP4; leading to stabilization and expression at the cell surface.
  • Glycosylation at Asn154
  • Modification sites at PhosphoSitePlus

Other Protein References for SPECC1L-ADORA2A Gene

ENSEMBL proteins:
Reactome Protein details:

No data available for DME Specific Peptides for SPECC1L-ADORA2A Gene

Domains for SPECC1L-ADORA2A Gene

Graphical View of Domain Structure for InterPro Entry



  • P29274
  • The cytoplasmic C-terminal domain is necessary for targeting the non-ubiquitinated form of this protein to the cell surface
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with SPECC1L-ADORA2A: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for SPECC1L-ADORA2A Gene

Function for SPECC1L-ADORA2A Gene

Molecular function for SPECC1L-ADORA2A Gene

UniProtKB/Swiss-Prot Function:
Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase

Gene Ontology (GO) - Molecular Function for SPECC1L-ADORA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001609 G-protein coupled adenosine receptor activity --
GO:0004930 G-protein coupled receptor activity --
GO:0005515 protein binding --
GO:0019899 enzyme binding --
GO:0042802 identical protein binding --
genes like me logo Genes that share ontologies with SPECC1L-ADORA2A: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SPECC1L-ADORA2A Gene

Localization for SPECC1L-ADORA2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPECC1L-ADORA2A Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SPECC1L-ADORA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane --
GO:0005887 integral component of plasma membrane --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SPECC1L-ADORA2A: view

No data available for Subcellular locations from COMPARTMENTS for SPECC1L-ADORA2A Gene

Pathways for SPECC1L-ADORA2A Gene

SuperPathways for SPECC1L-ADORA2A Gene

No Data Available

Interacting Proteins for SPECC1L-ADORA2A Gene

Gene Ontology (GO) - Biological Process for SPECC1L-ADORA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001973 adenosine receptor signaling pathway --
GO:0006171 cAMP biosynthetic process --
GO:0006909 phagocytosis --
GO:0006915 apoptotic process --
GO:0006954 inflammatory response --
genes like me logo Genes that share ontologies with SPECC1L-ADORA2A: view

No data available for Pathways by source for SPECC1L-ADORA2A Gene

Transcripts for SPECC1L-ADORA2A Gene


(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SPECC1L-ADORA2A Gene

No ASD Table

Relevant External Links for SPECC1L-ADORA2A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPECC1L-ADORA2A Gene

mRNA expression in normal human tissues for SPECC1L-ADORA2A Gene

genes like me logo Genes that share expressions with SPECC1L-ADORA2A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for SPECC1L-ADORA2A Gene

Orthologs for SPECC1L-ADORA2A Gene

This gene was present in the common ancestor of animals.

Orthologs for SPECC1L-ADORA2A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 36
  • 73 (a)
(Canis familiaris)
Mammalia SPECC1L 36
  • 78 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 51 (a)
(Mus musculus)
Mammalia Specc1l 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
(Gallus gallus)
Aves SPECC1L 36
  • 70 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
(Danio rerio)
Actinopterygii specc1la 36
  • 54 (a)
specc1lb 36
  • 50 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13366 36
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3677 36
  • 22 (a)
Species with no ortholog for SPECC1L-ADORA2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPECC1L-ADORA2A Gene

Gene Tree for SPECC1L-ADORA2A (if available)
Gene Tree for SPECC1L-ADORA2A (if available)

Paralogs for SPECC1L-ADORA2A Gene

Paralogs for SPECC1L-ADORA2A Gene

Selected SIMAP similar genes for SPECC1L-ADORA2A Gene using alignment to 1 proteins: Pseudogenes for SPECC1L-ADORA2A Gene

genes like me logo Genes that share paralogs with SPECC1L-ADORA2A: view

Variants for SPECC1L-ADORA2A Gene

Sequence variations from dbSNP and Humsavar for SPECC1L-ADORA2A Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs738815 -- 24,420,385(+) GAAGC(C/T)GGGGC intron-variant
rs5751869 -- 24,419,320(+) AGACC(A/G)GGCAC intron-variant
rs5760408 -- 24,419,283(+) GGGGA(A/G)CCTGC intron-variant
rs5760409 -- 24,419,383(+) TTTTG(A/T)CTGCA intron-variant
rs5760410 -- 24,419,438(+) TTAAG(A/G)GCCAA intron-variant

Relevant External Links for SPECC1L-ADORA2A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SPECC1L-ADORA2A Gene

Disorders for SPECC1L-ADORA2A Gene

No disorders were found for SPECC1L-ADORA2A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for SPECC1L-ADORA2A Gene

Publications for SPECC1L-ADORA2A Gene

  1. Evidence for transcript networks composed of chimeric RNAs in human cells. (PMID: 22238572) Djebali S. … Gingeras T.R. (PLoS ONE 2012) 3
  2. Molecular characterization of a human brain adenosine A2 receptor. (PMID: 1331670) Furlong T.J. … Shine J. (Brain Res. Mol. Brain Res. 1992) 4
  3. Site-directed mutagenesis identifies residues involved in ligand recognition in the human A2a adenosine receptor. (PMID: 7775460) Kim J. … Jacobson K.A. (J. Biol. Chem. 1995) 4
  4. Characterization and chromosomal localization of the human A2a adenosine receptor gene: ADORA2A. (PMID: 8670304) Le F. … Schofield P.R. (Biochem. Biophys. Res. Commun. 1996) 4
  5. Characterization of single-nucleotide polymorphisms in coding regions of human genes. (PMID: 10391209) Cargill M. … Lander E.S. (Nat. Genet. 1999) 4

Products for SPECC1L-ADORA2A Gene

Sources for SPECC1L-ADORA2A Gene

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