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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPECC1 Gene

protein-coding   GIFtS: 49
GCID: GC17P019914

sperm antigen with calponin homology and coiled-coil domains...
 Explore 4 diseases affiliated with
SPECC1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SPECC1    

Aliases
for SPECC1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Sperm Antigen With Calponin Homology And Coiled-Coil Domains 11 2 3     HCMOGT12
CYTSB1 2 3     Cytokinesis And Spindle Organization B2
HCMOGT-11 2     Cytospin-B1
NSP1 2     Sperm Antigen With Calponin-Like And Coiled Coil Domains 12
Nuclear Structure Protein 52 3     Structure Protein NSP5a3a2
Sperm Antigen HCMOGT-12 3     Structure Protein NSP5a3b2
NSP52 3     Structure Protein NSP5b3a2
FLJ369551     Structure Protein NSP5b3b2

External Ids:    HGNC: 306151   Entrez Gene: 925212   Ensembl: ENSG000001284877   OMIM: 6087935   UniProtKB: Q5M7753   

Export aliases for SPECC1 gene to outside databases

Previous GC identifers: GC17P019931 GC17P019853 GC17P019369


Summaries
for SPECC1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SPECC1:
The protein encoded by this gene belongs to the cytospin-A family. It is localized in the nucleus, and highly expressed
in testis and some cancer cell lines. A chromosomal translocation involving this gene and platelet-derived growth
factor receptor, beta gene (PDGFRB) may be a cause of juvenile myelomonocytic leukemia. Alternatively spliced
transcript variants encoding different isoforms have been described for this gene. (provided by RefSeq, Aug 2011)

Gene Wiki entry for SPECC1


Genomic Views
for SPECC1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SPECC1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SPECC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SPECC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPECC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p11.2

SPECC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPECC1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P019914:  view genomic region     (about GC identifiers)

Start:
 19,912,657 bp from pter      End:
 20,222,339 bp from pter
Size:
 309,683 bases      Orientation:
 plus strand

Proteins
for SPECC1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CYTSB_HUMAN, Q5M775 (See protein sequence)
Recommended Name: Cytospin-B  
Size: 1068 amino acids; 118585 Da
Subcellular location: Nucleus
Sequence caution: Sequence=AAH33618.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB16440.1; Type=Frameshift; Positions=8;
Secondary accessions: B4DHH0 B7WNS8 Q5IBP1 Q5IBP2 Q5IBP3 Q5IBP4 Q5M772 Q5M773 Q5M774 Q86XT8 Q8N4U4
Q8WU84 Q9HCQ3
Alternative splicing: 5 isoforms:  Q5M775-1   Q5M775-2   Q5M775-3   Q5M775-4   Q5M775-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SPECC1: NX_Q5M775

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5M775

    • SPECC1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (6 alternative transcripts): 
    NP_001028725.1  NP_001028726.1  NP_001028727.1  NP_001230367.1  NP_001230368.1  NP_690868.3  

    ENSEMBL proteins: 
     ENSP00000378898   ENSP00000463006   ENSP00000461918   ENSP00000464489   ENSP00000462266  
     ENSP00000464639   ENSP00000378900   ENSP00000261503   ENSP00000464341   ENSP00000461944  
     ENSP00000378901   ENSP00000463130   ENSP00000378893   ENSP00000378896   ENSP00000462471  
     ENSP00000462092   ENSP00000463799   ENSP00000462987   ENSP00000438294  

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    Novus Biologicals SPECC1 Proteins
    Novus Biologicals SPECC1 Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SPECC1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    SPECC1 for ontologies           About GeneDecksing



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    ThermoFisher Antibodies for SPECC1

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    Uscn ELISAs and CLIAs for SPECC1

    Protein Domains /
    Families
    for SPECC1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SPECC1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001715 CH-domain

    Graphical View of Domain Structure for InterPro Entry Q5M775

    ProtoNet protein and cluster: Q5M775

    1 Blocks protein family: IPB001715 Calponin-like actin-binding

    UniProtKB/Swiss-Prot: CYTSB_HUMAN, Q5M775
    Similarity: Belongs to the cytospin-A family
    Similarity: Contains 1 CH (calponin-homology) domain


    Function
    for SPECC1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPECC1
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate SPECC1:
    hsa-miR-579 hsa-miR-515-5p hsa-miR-31 hsa-miR-519e*
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): SPECC1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPECC1 (see all 7)
    OriGene shRNA RFP: SPECC1
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for SPECC1

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPECC1

    1 GenomeRNAi human phenotype for SPECC1:
     Synthetic lethal with Ras 


    Pathways & Interactions
    for SPECC1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPECC1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for SPECC1 (Q5M7753 ENSP000002615034) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    CBX7ENSP000002161334STRING: ENSP00000216133
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IDA--


    SPECC1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SPECC1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPECC1
    Search CenterWatch for drugs/clinical trials and news about SPECC1 / CYTSB 

    Transcripts
    for SPECC1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SPECC1 gene (6 alternative transcripts): 
    NM_001033553.2  NM_001033554.2  NM_001033555.2  NM_001243438.1  NM_001243439.1  NM_152904.4  

    Unigene Cluster for SPECC1:

    Sperm antigen with calponin homology and coiled-coil domains 1
    Hs.431045  [show with all ESTs]
    Unigene Representative Sequence: NM_152904
    18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000472876 ENST00000395527 ENST00000583482 ENST00000583528 ENST00000583463
    ENST00000578321 ENST00000582604 ENST00000413167 ENST00000395529(uc010cqx.3 uc002gwr.3 uc002gwu.3 uc002gwt.3)
    ENST00000261503(uc002gwq.3 uc002gws.3) ENST00000581973 ENST00000580934
    ENST00000582063 ENST00000579688 ENST00000395530(uc002gwv.3 uc010vzf.2)
    ENST00000467722 ENST00000395522 ENST00000395525

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPECC1
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate SPECC1:
    hsa-miR-579 hsa-miR-515-5p hsa-miR-31 hsa-miR-519e*
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): SPECC1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPECC1 (see all 7)
    OriGene shRNA RFP: SPECC1
    OriGene siRNA: SPECC1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPECC1
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SPECC1 (NM_001145468)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPECC1 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPECC1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPECC1

    Additional cDNA sequence: 

    AB041533.1 AK295093.1 AK295811.1 AK298601.1 AK301318.1 AK304186.1 AK314341.1 AY816326.1 
    AY816327.1 AY816328.1 AY816329.1 BC021123.1 BC033618.1 BC037532.1 BC050058.1 

    20 DOTS entries:

    DT.100788816  DT.427887  DT.307603  DT.99979848  DT.120916487  DT.100788815  DT.101972521  DT.100687808 
    DT.120916480  DT.120916556  DT.91928102  DT.100788819  DT.105917  DT.120916483  DT.120916553  DT.40198548 
    DT.40296455  DT.92430871  DT.95262607  DT.97786511 

    24/167 AceView cDNA sequences (see all 167):

    F26933 AW160798 BE892615 CF132177 AI817406 AI369680 AA489648 AI863341 
    BU620252 CR613965 CR623676 AI590214 AW054800 AW161631 BE501245 AI400557 
    BG249150 AW381570 BG700098 BE242496 BM839442 BF203527 BX406831 AI791316 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SPECC1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                                        -                                             
    SP2:                                                                                                      
    SP3:                                                                                                      
    SP4:                    -     -                                                                           
    SP5:              -                                                                                       


    ECgene alternative splicing isoforms for SPECC1

    Expression
    for SPECC1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPECC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SPECC1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartDorsal AortaHeart
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SPECC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPECC1

    SOURCE GeneReport for Unigene cluster: Hs.431045

    UniProtKB/Swiss-Prot: CYTSB_HUMAN, Q5M775
    Tissue specificity: Highly expressed in testis. Barely detectable in other tissues. Also highly expressed in some
    cancer cell lines

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    In Situ
    Assay Products:     
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    Orthologs
    for SPECC1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SPECC1 gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SPECC11 sperm antigen with calponin homology and coiled-coil more 72.05(n)
    72.74(a)    		   417595  XM_415840.3  XP_415840.3 
    African clawed frog
    (Xenopus laevis)    		 Amphibia LOC3987952 hypothetical protein LOC398795 78.09(n)    BC060019.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii specc11 sperm antigen with calponin homology and coiled-coil more 58.7(n)
    55.01(a)    		   562343  XM_685735.4  XP_690827.4 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG133666
    		 --
    		 21(a)
    		 1 → many
    		 X(504579-514228)
    worm
    (Caenorhabditis elegans)    		 Secernentea ehbp-16
    		 EH (Eps-15-homology) domain Binding Protein family...
    		 5(a)
    		 possible ortholog
    		 V(9550620-9556005)


    ENSEMBL Gene Tree for SPECC1 (if available)
    TreeFam Gene Tree for SPECC1 (if available) 

    Paralogs
    for SPECC1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPECC1 gene
    SMTNL22  SMTN2  SPECC1L2  SMTNL12  
    4 SIMAP similar genes for SPECC1 using alignment to 14 protein entries:     CYTSB_HUMAN (see all proteins):
    DMD    ACTN1    SPECC1L    CYTSA

    SPECC1 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for SPECC1
    PGOHUM00000262969 PGOHUM00000262974 PGOHUM00000262975 PGOHUM00000237300


    Genomic Variants
    for SPECC1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5155 NCBI SNPs in SPECC1 are shown (see all 5155)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs98946661,2
    		C,F,--19289693(+) AGAAAC/TTTTTC 1 -- us2k16Minor allele frequency- T:0.11NA WA EA 380
    rs99126481,2
    		C,F,A,--19289837(+) AAACAT/CGCCCA 1 -- us2k12Minor allele frequency- C:0.16WA EA 238
    rs748777851,2
    		F,--19290043(+) ATCAAT/CGCAAA 1 -- us2k11Minor allele frequency- C:0.09EA 120
    rs783314441,2
    		--19290209(+) CGTCCT/CTACAG 1 -- us2k11Minor allele frequency- C:0.01EA 120
    rs749676821,2
    		--19290534(+) CAACAC/GCGGCC 1 -- us2k11Minor allele frequency- G:0.01EA 120
    rs286535611,2
    		C,F,--19290573(+) CCCCTC/GTACCT 1 -- us2k12Minor allele frequency- G:0.12WA EA 238
    rs1112496501,2
    		C,--19290575(+) CCTCTA/TCCTGG 1 -- us2k14Minor allele frequency- T:0.09NA CSA EA 243
    rs785322871,2
    		C,--19291424(+) GCATCG/AGTGAG 1 -- ut511Minor allele frequency- A:0.50NA 2
    rs80675451,2
    		C,A,--19291455(+) GGGGGT/CTGCGG 1 -- ut514Minor allele frequency- C:0.33NA EA 244
    rs594126161,2
    		--19292200(+) GTGCTC/TGCTTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for SPECC1 (19912657 - 20162657 bp, first 250kb of SPECC1)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SPECC1: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for SPECC1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SPECC1 for disorders           About GeneDecksing

    OMIM gene information: 608793    OMIM disorders: --

    UniProtKB/Swiss-Prot: CYTSB_HUMAN, Q5M775
  • Note=A chromosomal aberration involving CYTSB may be a cause of juvenile myelomonocytic leukemia.
    • Translocation t(5;17)(q33;p11.2) with PDGFRB

    4 diseases for SPECC1:    About MalaCards
    juvenile myelomonocytic leukemia    myelomonocytic leukemia    leukemia    carcinoma


    Export disorders for SPECC1 gene to outside databases

    Publications
    for SPECC1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPECC1 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with SPECC1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A gene highly expressed in tumor cells encodes novel structure proteins. (PubMed id 15602574)1, 2, 3 Sang N.... Giordano A. (2004)
    2. HCMOGT-1 is a novel fusion partner to PDGFRB in juvenile myelomonocytic leukemia with t(5;17)(q33;p11.2). (PubMed id 15087372)1, 2, 3 Morerio C....Panarello C. (2004)
    3. Possible functional role of NSPs in cancer. (PubMed id 18763323)1, 3, 9 D'Agostino L. and Giordano A. (2008)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    9. A novel dual signaling axis for NSP 5a3a induced apopt osis in head and neck carcinoma. (PubMed id 22170762)1 D'Agostino L. and Giordano A. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    External Searches for SPECC1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing SPECC1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 92521 HGNC: 30615 AceView: HCMOGT-1 Ensembl:ENSG00000128487 euGenes: HUgn92521
    ECgene: SPECC1 H-InvDB: SPECC1

    Other Databases showing SPECC1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SPECC1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPECC1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SPECC1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SPECC1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SPECC1 gene:
    Search GeneIP for patents involving SPECC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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