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Aliases for SPECC1 Gene

Aliases for SPECC1 Gene

  • Sperm Antigen With Calponin Homology And Coiled-Coil Domains 1 2 3 4
  • Cytokinesis And Spindle Organization B 2 3
  • Nuclear Structure Protein 5 3 4
  • Sperm Antigen HCMOGT-1 3 4
  • HCMOGT1 3 6
  • CYTSB 3 4
  • NSP5 3 4
  • NSP 3 6
  • Sperm Antigen With Calponin-Like And Coiled Coil Domains 1 3
  • Structure Protein NSP5a3a 3
  • Structure Protein NSP5a3b 3
  • Structure Protein NSP5b3a 3
  • Structure Protein NSP5b3b 3
  • Sperm Antigen HCMOGT 1 2
  • Cytospin B 2
  • Cytospin-B 3
  • HCMOGT-1 3

External Ids for SPECC1 Gene

Previous GeneCards Identifiers for SPECC1 Gene

  • GC17P019931
  • GC17P019853
  • GC17P019369
  • GC17P019914

Summaries for SPECC1 Gene

Entrez Gene Summary for SPECC1 Gene

  • The protein encoded by this gene belongs to the cytospin-A family. It is localized in the nucleus, and highly expressed in testis and some cancer cell lines. A chromosomal translocation involving this gene and platelet-derived growth factor receptor, beta gene (PDGFRB) may be a cause of juvenile myelomonocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for SPECC1 Gene

SPECC1 (Sperm Antigen With Calponin Homology And Coiled-Coil Domains 1) is a Protein Coding gene. An important paralog of this gene is SMTNL2.

Gene Wiki entry for SPECC1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPECC1 Gene

Genomics for SPECC1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SPECC1 Gene

Start:
20,009,336 bp from pter
End:
20,319,026 bp from pter
Size:
309,691 bases
Orientation:
Plus strand

Genomic View for SPECC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPECC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPECC1 Gene

No data available for Regulatory Elements for SPECC1 Gene

Proteins for SPECC1 Gene

  • Protein details for SPECC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5M775-CYTSB_HUMAN
    Recommended name:
    Cytospin-B
    Protein Accession:
    Q5M775
    Secondary Accessions:
    • B4DHH0
    • B7WNS8
    • Q5IBP1
    • Q5IBP2
    • Q5IBP3
    • Q5IBP4
    • Q5M772
    • Q5M773
    • Q5M774
    • Q86XT8
    • Q8N4U4
    • Q8WU84
    • Q9HCQ3

    Protein attributes for SPECC1 Gene

    Size:
    1068 amino acids
    Molecular mass:
    118585 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH33618.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB16440.1; Type=Frameshift; Positions=8; Evidence={ECO:0000305};

    Alternative splice isoforms for SPECC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPECC1 Gene

Proteomics data for SPECC1 Gene at MOPED

Post-translational modifications for SPECC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SPECC1 Gene

Domains for SPECC1 Gene

Protein Domains for SPECC1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SPECC1 Gene

Graphical View of Domain Structure for InterPro Entry

Q5M775

UniProtKB/Swiss-Prot:

CYTSB_HUMAN :
  • Q5M775
Domain:
  • Contains 1 CH (calponin-homology) domain.
Family:
  • Belongs to the cytospin-A family.
genes like me logo Genes that share domains with SPECC1: view

No data available for Gene Families for SPECC1 Gene

Function for SPECC1 Gene

Gene Ontology (GO) - Molecular Function for SPECC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SPECC1: view

Phenotypes for SPECC1 Gene

GenomeRNAi human phenotypes for SPECC1:
genes like me logo Genes that share phenotypes with SPECC1: view

Animal Model Products

CRISPR Products

miRNA for SPECC1 Gene

miRTarBase miRNAs that target SPECC1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SPECC1 Gene

Localization for SPECC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPECC1 Gene

Gene Ontology (GO) - Cellular Components for SPECC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SPECC1: view

No data available for Subcellular locations from COMPARTMENTS for SPECC1 Gene

Pathways for SPECC1 Gene

SuperPathways for SPECC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPECC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IDA 21703590
genes like me logo Genes that share ontologies with SPECC1: view

No data available for Pathways by source for SPECC1 Gene

Transcripts for SPECC1 Gene

Unigene Clusters for SPECC1 Gene

Sperm antigen with calponin homology and coiled-coil domains 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPECC1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SPECC1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPECC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: -
SP2:
SP3:
SP4: - -
SP5: -

Relevant External Links for SPECC1 Gene

GeneLoc Exon Structure for
SPECC1
ECgene alternative splicing isoforms for
SPECC1

Expression for SPECC1 Gene

mRNA expression in normal human tissues for SPECC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPECC1 Gene

SOURCE GeneReport for Unigene cluster for SPECC1 Gene Hs.431045

mRNA Expression by UniProt/SwissProt for SPECC1 Gene

Q5M775-CYTSB_HUMAN
Tissue specificity: Highly expressed in testis. Barely detectable in other tissues. Also highly expressed in some cancer cell lines.
genes like me logo Genes that share expressions with SPECC1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SPECC1 Gene

Orthologs for SPECC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPECC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPECC1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPECC1 35
  • 78.67 (n)
  • 80.72 (a)
SPECC1 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPECC1 35
  • 85.33 (n)
  • 87.54 (a)
SPECC1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Specc1 35
  • 83.82 (n)
  • 85.71 (a)
Specc1 16
Specc1 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPECC1 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPECC1 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Specc1 35
  • 82.73 (n)
  • 84.7 (a)
chicken
(Gallus gallus)
Aves SPECC1 35
  • 72.05 (n)
  • 72.74 (a)
SPECC1 36
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398795 35
tropical clawed frog
(Silurana tropicalis)
Amphibia specc1 35
  • 65.36 (n)
  • 62.43 (a)
Str.17349 35
zebrafish
(Danio rerio)
Actinopterygii specc1 35
  • 58.68 (n)
  • 55.06 (a)
specc1 36
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13366 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3677 36
  • 28 (a)
OneToMany
Species with no ortholog for SPECC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPECC1 Gene

ENSEMBL:
Gene Tree for SPECC1 (if available)
TreeFam:
Gene Tree for SPECC1 (if available)

Paralogs for SPECC1 Gene

Pseudogenes.org Pseudogenes for SPECC1 Gene

genes like me logo Genes that share paralogs with SPECC1: view

Variants for SPECC1 Gene

Sequence variations from dbSNP and Humsavar for SPECC1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs16711 -- 20,179,106(-) TTATT(-/TTTCTTCCTA)AGCCA intron-variant
rs733794 -- 20,254,644(-) CACAT(A/G)GACAC intron-variant
rs757494 -- 20,247,027(-) GCTGA(A/G)TGGAG intron-variant
rs757495 -- 20,246,705(-) TCTTC(G/T)ATTTG intron-variant
rs767751 -- 20,297,175(+) AAGTA(G/T)AAGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPECC1 Gene

Variant ID Type Subtype PubMed ID
nsv907868 CNV Gain 21882294
nsv907869 CNV Loss 21882294
nsv833394 CNV Gain 17160897
nsv907870 CNV Gain 21882294
nsv907871 CNV Loss 21882294
nsv907872 CNV Loss 21882294
nsv833395 CNV Loss 17160897
nsv833396 CNV Gain 17160897
nsv2003 CNV Loss 18451855
esv2673344 CNV Deletion 23128226
esv271574 CNV Insertion 20981092
nsv520772 CNV Loss 19592680
esv2715739 CNV Deletion 23290073
esv2102373 CNV Deletion 18987734
esv2715741 CNV Deletion 23290073
nsv521025 CNV Gain 19592680

Relevant External Links for SPECC1 Gene

HapMap Linkage Disequilibrium report
SPECC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPECC1 Gene

Disorders for SPECC1 Gene

UniProtKB/Swiss-Prot

CYTSB_HUMAN
  • Note=A chromosomal aberration involving CYTSB may be a cause of juvenile myelomonocytic leukemia. Translocation t(5;17)(q33;p11.2) with PDGFRB.

No disorders were found for SPECC1 Gene.

Publications for SPECC1 Gene

  1. Possible functional role of NSPs in cancer. (PMID: 18763323) D'Agostino L. … Giordano A. (Cell Cycle 2008) 2 3 23
  2. HCMOGT-1 is a novel fusion partner to PDGFRB in juvenile myelomonocytic leukemia with t(5;17)(q33;p11.2). (PMID: 15087372) Morerio C. … Panarello C. (Cancer Res. 2004) 2 3 4
  3. A gene highly expressed in tumor cells encodes novel structure proteins. (PMID: 15602574) Sang N. … Giordano A. (Oncogene 2004) 2 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SPECC1 Gene

Sources for SPECC1 Gene

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