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SPDYE7P Gene

pseudogene   GIFtS: 25
GCID: GC07M072334

Speedy/RINGO Cell Cycle Regulator Family Member E7, Pseudogene

(Previous names: speedy homolog E7 (Xenopus laevis), pseudogene)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Speedy/RINGO Cell Cycle Regulator Family Member E7, Pseudogene1 2
Speedy Homolog E7 (Xenopus Laevis), Pseudogene1
Speedy Protein E7 Pseudogene3

External Ids:    HGNC: 354661   Entrez Gene: 4412512   Ensembl: ENSG000001799947   UniProtKB: Q495Y73   

Export aliases for SPDYE7P gene to outside databases

Previous GC identifer: GC07M071973


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SPDYE7P Gene:
SPDYE7P (speedy/RINGO cell cycle regulator family member E7, pseudogene) is a pseudogene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPDYE7P gene promoter:
         RFX1   AML1a   Pax-6   E47   Arnt   Evi-1   PPAR-gamma1   Hand1   PPAR-gamma2   Meis-1a   
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPDYE7P


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.23   Ensembl cytogenetic band:  7q11.23   HGNC cytogenetic band: 7q11.23

SPDYE7P Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPDYE7P gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M072334:  view genomic region     (about GC identifiers)

Start:
72,333,318 bp from pter      End:
72,341,076 bp from pter
Size:
7,759 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 71,666,140-71,672,477     
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for SPDYE7P

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SPDE7_HUMAN, Q495Y7 (See protein sequence)
Recommended Name: Putative speedy protein E7  
Size: 208 amino acids; 25253 Da
Caution: Could be the product of a pseudogene

Explore the universe of human proteins at neXtProt for SPDYE7P: NX_Q495Y7


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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
SPDY: Speedy homologs

1 InterPro protein domain:
 IPR020984 Cell_cycle_regulatory_Spy1

Graphical View of Domain Structure for InterPro Entry Q495Y7

ProtoNet protein and cluster: Q495Y7

UniProtKB/Swiss-Prot: SPDE7_HUMAN, Q495Y7
Similarity: Belongs to the Speedy/Ringo family


Find genes that share domains with SPDYE7P           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     1 GenomeRNAi human phenotype for SPDYE7P:
 Increased HPV18 LCR reporter a 

Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPDYE7P
Interactions:

    Search GeneGlobe Interaction Network for SPDYE7P

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for SPDYE7P (SPDE7)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for SPDYE7P gene: 
NM_001034844.1  

Unigene Cluster for SPDYE7P:

Speedy homolog E7 (Xenopus laevis), pseudogene
Hs.591819
Unigene Representative Sequence: BC100974
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000355920 ENST00000420373
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Additional mRNA sequence: BC100974.2 

1 DOTS entry:

DT.121057996 

1 AceView cDNA sequence:

AW393752 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SPDYE7P expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTGTCCTACC
SPDYE7P Expression
About this image

SPDYE7P Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.591819
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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ENSEMBL Gene Tree for SPDYE7P (if available)
TreeFam Gene Tree for SPDYE7P (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SPDYE7P gene
9 SIMAP similar genes for SPDYE7P using alignment to 1 protein entry:     SPDE7_HUMAN:
SPDYE3    SPDYE1    SPDYE5    SPDYE4    SPDYB2-L1    SPDYE2
SPDYE2B    SPDYE6    SPY1

Find genes that share paralogs with SPDYE7P           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SPDYE7P (see all 199)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs40864821,2
--72332818(-) TTCCCT/CACCAG 1 -- ds50012Minor allele frequency- C:0.00NA 4
rs1481487201,2
--72332987(+) CTTTAG/TGTATA 1 -- ds50010--------
rs1852349471,2
--72333214(+) TGTGCC/TTTCAA 1 -- ds50010--------
rs1504371631,2
C--72333248(+) AGTCCA/GTAAGA 1 -- ds50010--------
rs1382646401,2
--72333324(+) CGCAGG/TAAAGG 1 -- nc-transcript-variant0--------
rs1897423791,2
--72333330(+) AAAGGA/GTGGAA 1 -- nc-transcript-variant0--------
rs1829145261,2
--72333362(+) TACTTC/TTCTCC 1 -- nc-transcript-variant0--------
rs1430014491,2
C--72333455(+) TGGTCC/TAGGTT 1 -- nc-transcript-variant0--------
rs1461523731,2
--72333538(+) CTGCTA/GAAAAT 1 -- nc-transcript-variant0--------
rs1390177051,2
--72333559(+) CCTGGA/GTCCGG 1 -- nc-transcript-variant0--------

HapMap Linkage Disequilibrium report for SPDYE7P (72333318 - 72341076 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for SPDYE7P (see all 13):    About this table    
Variant IDTypeSubtypePubMed ID
nsv8133CNV Gain18304495
esv34349CNV Gain17911159
nsv428171CNV Gain18775914
dgv1116n67CNV Gain20364138
nsv469793CNV Gain16826518
esv23205CNV Gain19812545
nsv888362CNV Gain21882294
nsv520573CNV Gain+Loss19592680
dgv2095e1CNV Complex17122850
dgv2099e1CNV Complex17122850

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SPDYE7P gene integrated from 10 sources:
(articles sorted by number of sources associating them with SPDYE7P)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  2. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (Nature 2003)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 441251 HGNC: 35466 AceView: LOC441251.1 Ensembl:ENSG00000179994 euGenes: HUgn441251
ECgene: SPDYE7P H-InvDB: SPDYE7P

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SPDYE7P gene:
Search GeneIP for patents involving SPDYE7P

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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