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Aliases for SPDYE5 Gene

Aliases for SPDYE5 Gene

  • Speedy/RINGO Cell Cycle Regulator Family Member E5 2 3 5
  • Speedy Homolog E5 (Xenopus Laevis) 2

External Ids for SPDYE5 Gene

Previous GeneCards Identifiers for SPDYE5 Gene

  • GC07P074964
  • GC07P075123
  • GC07P074457

Summaries for SPDYE5 Gene

GeneCards Summary for SPDYE5 Gene

SPDYE5 (Speedy/RINGO Cell Cycle Regulator Family Member E5) is a Protein Coding gene. Among its related pathways are Oocyte meiosis. An important paralog of this gene is SPDYE2.

Additional gene information for SPDYE5 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPDYE5 Gene

Genomics for SPDYE5 Gene

GeneHancer (GH) Regulatory Elements for SPDYE5 Gene

Promoters and enhancers for SPDYE5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I074635 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 33.8 -857.1 -857146 2 PKNOX1 FOXA2 ZFP64 ARID4B SIN3A ZNF48 ETS1 FOS ZNF202 REST PMS2P3 STAG3L1 NSUN5P1 MIR590 SPDYE5 METTL27 GTF2IRD2 GTF2IRD2B LOC101926943 BUD23
GH07I076313 Enhancer 1.5 Ensembl ENCODE dbSUPER 31.7 +821.2 821157 1.4 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A ZNF2 IRF4 YY1 STAG3L1 PMS2P3 FAM185BP NSUN5P1 SPDYE18 SPDYE5 POMZP3 PMS2P9 SPDYE17 LOC100422695
GH07I076372 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 24.3 +880.2 880161 1.2 HDGF PKNOX1 ARNT ZNF280A POLR2B ZNF766 ARID2 FOS ATF7 ZNF263 SPDYE5 DTX2P1 PMS2P9 PMS2P3 DTX2 SPDYE17 SPDYE18 NSUN5P1 CCDC146 FAM185BP
GH07I076301 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 15.4 +813.6 813568 10.2 HDGF PKNOX1 FOXA2 CLOCK SMAD1 ARID4B NEUROD1 SIN3A FEZF1 ZBTB7B GC07P076306 HSPB1 POMZP3 PMS2P3 SPDYE5 SPDYE18 STAG3L1 SPDYE17 SRRM3 PMS2P9
GH07I075637 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 22.8 +146.2 146197 3.6 ARNT SIN3A ZNF2 ZBTB7B ZNF766 REST SMARCA4 GLIS1 NBN KDM1A SPDYE5 HIP1 STAG3L1 PMS2P3 NSUN5P1 GTF2IRD2B GTF2IRD2 LOC101926943 TRIM73 DTX2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPDYE5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPDYE5 gene promoter:

Genomic Locations for SPDYE5 Gene

Genomic Locations for SPDYE5 Gene
chr7:75,493,182-75,504,304
(GRCh38/hg38)
Size:
11,123 bases
Orientation:
Plus strand
chr7:75,123,401-75,133,628
(GRCh37/hg19)

Genomic View for SPDYE5 Gene

Genes around SPDYE5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPDYE5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPDYE5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPDYE5 Gene

Proteins for SPDYE5 Gene

  • Protein details for SPDYE5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NIY4-SPDE5_HUMAN
    Recommended name:
    Putative speedy protein E5
    Protein Accession:
    A6NIY4

    Protein attributes for SPDYE5 Gene

    Size:
    337 amino acids
    Molecular mass:
    40483 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPDYE5 Gene

Post-translational modifications for SPDYE5 Gene

No Post-translational modifications

Other Protein References for SPDYE5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPDYE5 Gene

Domains & Families for SPDYE5 Gene

Gene Families for SPDYE5 Gene

Protein Domains for SPDYE5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPDYE5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NIY4

UniProtKB/Swiss-Prot:

SPDE5_HUMAN :
  • Belongs to the Speedy/Ringo family.
Family:
  • Belongs to the Speedy/Ringo family.
genes like me logo Genes that share domains with SPDYE5: view

Function for SPDYE5 Gene

Phenotypes From GWAS Catalog for SPDYE5 Gene

Gene Ontology (GO) - Molecular Function for SPDYE5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IBA --
genes like me logo Genes that share ontologies with SPDYE5: view

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPDYE5 Gene

Localization for SPDYE5 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SPDYE5 Gene

Pathways & Interactions for SPDYE5 Gene

SuperPathways for SPDYE5 Gene

SuperPathway Contained pathways
1 Oocyte meiosis
genes like me logo Genes that share pathways with SPDYE5: view

Pathways by source for SPDYE5 Gene

Interacting Proteins for SPDYE5 Gene

Gene Ontology (GO) - Biological Process for SPDYE5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045859 regulation of protein kinase activity IBA --
genes like me logo Genes that share ontologies with SPDYE5: view

No data available for SIGNOR curated interactions for SPDYE5 Gene

Drugs & Compounds for SPDYE5 Gene

No Compound Related Data Available

Transcripts for SPDYE5 Gene

mRNA/cDNA for SPDYE5 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPDYE5 Gene

Speedy homolog E5 (Xenopus laevis):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPDYE5 Gene

No ASD Table

Relevant External Links for SPDYE5 Gene

GeneLoc Exon Structure for
SPDYE5
ECgene alternative splicing isoforms for
SPDYE5

Expression for SPDYE5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPDYE5 Gene

mRNA expression in normal human tissues for SPDYE5 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPDYE5 Gene:

SPDYE5

SOURCE GeneReport for Unigene cluster for SPDYE5 Gene:

Hs.632298
genes like me logo Genes that share expression patterns with SPDYE5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPDYE5 Gene

Orthologs for SPDYE5 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SPDYE5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC742265 33
  • 98.25 (n)
Species where no ortholog for SPDYE5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPDYE5 Gene

ENSEMBL:
Gene Tree for SPDYE5 (if available)
TreeFam:
Gene Tree for SPDYE5 (if available)

Paralogs for SPDYE5 Gene

Paralogs for SPDYE5 Gene

(9) SIMAP similar genes for SPDYE5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPDYE5: view

Variants for SPDYE5 Gene

Sequence variations from dbSNP and Humsavar for SPDYE5 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs10230587 -- 75,494,283(+) C/A intron_variant
rs10274653 -- 75,491,667(+) C/T upstream_transcript_variant
rs10441325 -- 75,494,456(+) C/A intron_variant
rs1062117 -- 75,493,577(+) G/A upstream_transcript_variant
rs111295044 -- 75,494,029(+) C/A 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for SPDYE5 Gene

Variant ID Type Subtype PubMed ID
dgv120n16 CNV deletion 17901297
dgv3858e59 CNV duplication 20981092
esv21917 CNV gain 19812545
esv3613722 CNV loss 21293372
nsv482105 CNV gain 20164927
nsv528969 CNV gain 19592680
nsv607509 CNV gain 21841781
nsv8157 CNV gain+loss 18304495
nsv831036 CNV loss 17160897
nsv971041 CNV duplication 23825009
nsv981535 CNV duplication 23825009

Additional Variant Information for SPDYE5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPDYE5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SPDYE5 Gene

Disorders for SPDYE5 Gene

Additional Disease Information for SPDYE5

No disorders were found for SPDYE5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPDYE5 Gene

Publications for SPDYE5 Gene

  1. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58

Products for SPDYE5 Gene

Sources for SPDYE5 Gene

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