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Aliases for SPDYE4 Gene

Aliases for SPDYE4 Gene

  • Speedy/RINGO Cell Cycle Regulator Family Member E4 2 3 5
  • Speedy Homolog E4 (Xenopus Laevis) 2

External Ids for SPDYE4 Gene

Previous GeneCards Identifiers for SPDYE4 Gene

  • GC17M008599

Summaries for SPDYE4 Gene

GeneCards Summary for SPDYE4 Gene

SPDYE4 (Speedy/RINGO Cell Cycle Regulator Family Member E4) is a Protein Coding gene. Among its related pathways are Oocyte meiosis. An important paralog of this gene is SPDYE5.

Additional gene information for SPDYE4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPDYE4 Gene

Genomics for SPDYE4 Gene

GeneHancer (GH) Regulatory Elements for SPDYE4 Gene

Promoters and enhancers for SPDYE4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I008758 Promoter 0.6 EPDnew 550.8 +0.9 918 0.1 ATF2 SPDYE4 CCDC42
GH17I008364 Enhancer 0.9 FANTOM5 Ensembl ENCODE 46.5 +393.4 393436 2.4 STAT1 POLR2A JUN ZNF600 ATF2 ENSG00000265749 ODF4 CCDC42 SPDYE4 ENSG00000212206 ENSG00000226871 RNF222 NDEL1 MFSD6L CNTROB
GH17I008744 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 18.8 +13.8 13817 1.9 HDGF ARID4B SIN3A DMAP1 ZNF48 GLIS2 ZNF213 ZNF143 KLF13 SP3 CCDC42 LOC105371529 SPDYE4 ODF4 MFSD6L
GH17I008962 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.6 -205.8 -205801 4.6 PKNOX1 RB1 SIN3A BATF KLF5 GLIS2 ZNF207 ZNF143 ATF7 IKZF2 PIK3R5 CTB-41I6.1 ENSG00000266389 SPDYE4 ENSG00000265975 GC17M008877
GH17I008933 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 13.9 -175.7 -175659 2.3 SRF RFX1 ZBED1 JUNB REST BATF ATF2 RELA IKZF1 NFATC1 PIK3R5 SPDYE4 NTN1 NDEL1 GC17M008877
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPDYE4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPDYE4 gene promoter:

Genomic Locations for SPDYE4 Gene

Genomic Locations for SPDYE4 Gene
chr17:8,746,868-8,759,412
(GRCh38/hg38)
Size:
12,545 bases
Orientation:
Minus strand
chr17:8,656,424-8,661,877
(GRCh37/hg19)

Genomic View for SPDYE4 Gene

Genes around SPDYE4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPDYE4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPDYE4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPDYE4 Gene

Proteins for SPDYE4 Gene

  • Protein details for SPDYE4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NLX3-SPDE4_HUMAN
    Recommended name:
    Speedy protein E4
    Protein Accession:
    A6NLX3
    Secondary Accessions:
    • B2RUZ6

    Protein attributes for SPDYE4 Gene

    Size:
    237 amino acids
    Molecular mass:
    27806 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPDYE4 Gene

Post-translational modifications for SPDYE4 Gene

No Post-translational modifications

Other Protein References for SPDYE4 Gene

No data available for DME Specific Peptides for SPDYE4 Gene

Domains & Families for SPDYE4 Gene

Gene Families for SPDYE4 Gene

Protein Domains for SPDYE4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPDYE4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NLX3

UniProtKB/Swiss-Prot:

SPDE4_HUMAN :
  • Belongs to the Speedy/Ringo family.
Family:
  • Belongs to the Speedy/Ringo family.
genes like me logo Genes that share domains with SPDYE4: view

Function for SPDYE4 Gene

Gene Ontology (GO) - Molecular Function for SPDYE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IBA --
genes like me logo Genes that share ontologies with SPDYE4: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPDYE4 Gene

Localization for SPDYE4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPDYE4 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SPDYE4 Gene

Pathways & Interactions for SPDYE4 Gene

SuperPathways for SPDYE4 Gene

SuperPathway Contained pathways
1 Oocyte meiosis
genes like me logo Genes that share pathways with SPDYE4: view

Pathways by source for SPDYE4 Gene

Interacting Proteins for SPDYE4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000329522%0d%0a9606.ENSP00000321656%0d%0a
Selected Interacting proteins: ENSP00000329522 for SPDYE4 Gene via STRING

Symbol External ID(s) Details
CDC25C

Gene Ontology (GO) - Biological Process for SPDYE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045859 regulation of protein kinase activity IBA --
genes like me logo Genes that share ontologies with SPDYE4: view

No data available for SIGNOR curated interactions for SPDYE4 Gene

Drugs & Compounds for SPDYE4 Gene

No Compound Related Data Available

Transcripts for SPDYE4 Gene

mRNA/cDNA for SPDYE4 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPDYE4 Gene

Speedy homolog E4 (Xenopus laevis):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPDYE4 Gene

No ASD Table

Relevant External Links for SPDYE4 Gene

GeneLoc Exon Structure for
SPDYE4
ECgene alternative splicing isoforms for
SPDYE4

Expression for SPDYE4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPDYE4 Gene

mRNA differential expression in normal tissues according to GTEx for SPDYE4 Gene

This gene is overexpressed in Testis (x41.3).

NURSA nuclear receptor signaling pathways regulating expression of SPDYE4 Gene:

SPDYE4

SOURCE GeneReport for Unigene cluster for SPDYE4 Gene:

Hs.368429
genes like me logo Genes that share expression patterns with SPDYE4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPDYE4 Gene

Orthologs for SPDYE4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPDYE4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPDYE4 33 34
  • 98.47 (n)
dog
(Canis familiaris)
Mammalia LOC607286 33
  • 80.21 (n)
-- 34
  • 76 (a)
ManyToMany
-- 34
  • 76 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 56 (a)
OneToMany
mouse
(Mus musculus)
Mammalia 4933411G11Rik 34
  • 54 (a)
ManyToMany
Spdyb 34
  • 51 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 36 (a)
ManyToMany
-- 34
  • 34 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 21 (a)
OneToMany
Species where no ortholog for SPDYE4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPDYE4 Gene

ENSEMBL:
Gene Tree for SPDYE4 (if available)
TreeFam:
Gene Tree for SPDYE4 (if available)

Paralogs for SPDYE4 Gene

Paralogs for SPDYE4 Gene

(9) SIMAP similar genes for SPDYE4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SPDYE4: view

Variants for SPDYE4 Gene

Sequence variations from dbSNP and Humsavar for SPDYE4 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000397915 -- 8,749,502(-) G/C genic_downstream_transcript_variant, intron_variant
rs1000467774 -- 8,757,934(-) C/T intron_variant
rs1000647533 -- 8,754,878(-) G/A intron_variant
rs1000682732 -- 8,747,693(-) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000740509 -- 8,752,604(-) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SPDYE4 Gene

Variant ID Type Subtype PubMed ID
esv2761945 CNV loss 21179565
esv3639890 CNV gain 21293372
nsv518675 CNV gain 19592680
nsv960406 CNV duplication 23825009

Variation tolerance for SPDYE4 Gene

Residual Variation Intolerance Score: 62.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.21; 52.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPDYE4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPDYE4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPDYE4 Gene

Disorders for SPDYE4 Gene

Additional Disease Information for SPDYE4

No disorders were found for SPDYE4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPDYE4 Gene

Publications for SPDYE4 Gene

  1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for SPDYE4 Gene

Sources for SPDYE4 Gene

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