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Aliases for SPDYE4 Gene

Aliases for SPDYE4 Gene

  • Speedy/RINGO Cell Cycle Regulator Family Member E4 2 3 5
  • Speedy Homolog E4 (Xenopus Laevis) 2

External Ids for SPDYE4 Gene

Previous GeneCards Identifiers for SPDYE4 Gene

  • GC17M008599

Summaries for SPDYE4 Gene

GeneCards Summary for SPDYE4 Gene

SPDYE4 (Speedy/RINGO Cell Cycle Regulator Family Member E4) is a Protein Coding gene. Among its related pathways are Oocyte meiosis. An important paralog of this gene is SPDYE16.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPDYE4 Gene

Genomics for SPDYE4 Gene

Regulatory Elements for SPDYE4 Gene

Enhancers for SPDYE4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F008364 1.5 FANTOM5 Ensembl ENCODE 46.5 +393.4 393436 2.4 STAT1 ZNF366 POLR2A SMARCA4 JUN ZNF600 ODF4 CCDC42 SPDYE4 LOC105371523 ENSG00000212206 ENSG00000226871 RNF222 NDEL1 MFSD6L CNTROB
GH17F008933 1.2 FANTOM5 Ensembl ENCODE 13.9 -175.7 -175660 2.3 SRF ZBED1 JUNB USF2 REST ZNF48 RELA SREBF1 ZFHX2 RAD51 PIK3R5 SPDYE4 NTN1 NDEL1 GC17M008877
GH17F008782 0.9 Ensembl ENCODE 11.5 -23.0 -22990 0.8 ZBTB11 MFSD6L CCDC42 SPDYE4 RNF222 LOC105371530 GC17P008796
GH17F008785 0.8 Ensembl ENCODE 11.5 -26.6 -26599 0.8 ZSCAN5A CTCF ZNF654 TRIM22 REST ZNF2 RAD21 ZBTB48 ZNF143 SMC3 MFSD6L CCDC42 SPDYE4 GC17P008796 LOC105371530
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SPDYE4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPDYE4 Gene

8,746,868 bp from pter
8,759,412 bp from pter
12,545 bases
Minus strand

Genomic View for SPDYE4 Gene

Genes around SPDYE4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPDYE4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPDYE4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPDYE4 Gene

Proteins for SPDYE4 Gene

  • Protein details for SPDYE4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Speedy protein E4
    Protein Accession:
    Secondary Accessions:
    • B2RUZ6

    Protein attributes for SPDYE4 Gene

    237 amino acids
    Molecular mass:
    27806 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPDYE4 Gene

Post-translational modifications for SPDYE4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPDYE4 Gene

No data available for DME Specific Peptides for SPDYE4 Gene

Domains & Families for SPDYE4 Gene

Gene Families for SPDYE4 Gene

Protein Domains for SPDYE4 Gene


Suggested Antigen Peptide Sequences for SPDYE4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Speedy/Ringo family.
  • Belongs to the Speedy/Ringo family.
genes like me logo Genes that share domains with SPDYE4: view

Function for SPDYE4 Gene

Gene Ontology (GO) - Molecular Function for SPDYE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IBA --
genes like me logo Genes that share ontologies with SPDYE4: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPDYE4 Gene

Localization for SPDYE4 Gene

Subcellular locations from

Jensen Localization Image for SPDYE4 Gene COMPARTMENTS Subcellular localization image for SPDYE4 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SPDYE4 Gene

Pathways & Interactions for SPDYE4 Gene

SuperPathways for SPDYE4 Gene

SuperPathway Contained pathways
1 Oocyte meiosis
genes like me logo Genes that share pathways with SPDYE4: view

Pathways by source for SPDYE4 Gene

Interacting Proteins for SPDYE4 Gene

Gene Ontology (GO) - Biological Process for SPDYE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045859 regulation of protein kinase activity IBA --
genes like me logo Genes that share ontologies with SPDYE4: view

No data available for SIGNOR curated interactions for SPDYE4 Gene

Transcripts for SPDYE4 Gene

mRNA/cDNA for SPDYE4 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPDYE4 Gene

Speedy homolog E4 (Xenopus laevis):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPDYE4 Gene

No ASD Table

Relevant External Links for SPDYE4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPDYE4 Gene

mRNA expression in normal human tissues for SPDYE4 Gene

mRNA differential expression in normal tissues according to GTEx for SPDYE4 Gene

This gene is overexpressed in Testis (x41.3).

NURSA nuclear receptor signaling pathways regulating expression of SPDYE4 Gene:


SOURCE GeneReport for Unigene cluster for SPDYE4 Gene:

genes like me logo Genes that share expression patterns with SPDYE4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SPDYE4 Gene

Orthologs for SPDYE4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPDYE4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPDYE4 34 35
  • 98.47 (n)
(Canis familiaris)
Mammalia LOC607286 34
  • 80.21 (n)
-- 35
  • 76 (a)
-- 35
  • 76 (a)
(Bos Taurus)
Mammalia -- 35
  • 56 (a)
(Mus musculus)
Mammalia 4933411G11Rik 35
  • 54 (a)
Spdyb 35
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 36 (a)
-- 35
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 21 (a)
Species where no ortholog for SPDYE4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPDYE4 Gene

Gene Tree for SPDYE4 (if available)
Gene Tree for SPDYE4 (if available)

Paralogs for SPDYE4 Gene

Paralogs for SPDYE4 Gene

(9) SIMAP similar genes for SPDYE4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SPDYE4: view

Variants for SPDYE4 Gene

Sequence variations from dbSNP and Humsavar for SPDYE4 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs111500769 -- 8,757,630(+) CACCT(-/TTCTCC)TTCTC intron-variant
rs111535957 -- 8,757,284(+) GCCTC(A/G)TGGTG intron-variant, reference, synonymous-codon
rs112115935 -- 8,749,406(+) CTACA(A/G)GCGCA intron-variant, downstream-variant-500B
rs112312955 -- 8,756,239(+) CAAAA(C/T)GTGGG intron-variant
rs113027375 -- 8,750,711(+) CTCAA(-/AAAC)AAACA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SPDYE4 Gene

Variant ID Type Subtype PubMed ID
esv2761945 CNV loss 21179565
esv3639890 CNV gain 21293372
nsv518675 CNV gain 19592680
nsv960406 CNV duplication 23825009

Variation tolerance for SPDYE4 Gene

Residual Variation Intolerance Score: 62.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.21; 52.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPDYE4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPDYE4 Gene

Disorders for SPDYE4 Gene

Relevant External Links for SPDYE4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SPDYE4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPDYE4 Gene

Publications for SPDYE4 Gene

  1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for SPDYE4 Gene

Sources for SPDYE4 Gene

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