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Aliases for SPDYE3 Gene

Aliases for SPDYE3 Gene

  • Speedy/RINGO Cell Cycle Regulator Family Member E3 2 3 5
  • Speedy Homolog E3 (Xenopus Laevis) 2
  • Putative WBSCR19-Like Protein 7 3
  • Putative Speedy Protein E3 3
  • Speedy Homolog E3 3
  • Speedy Protein E3 3
  • SPDYB2 3

External Ids for SPDYE3 Gene

Previous GeneCards Identifiers for SPDYE3 Gene

  • GC07P099744
  • GC07P099905
  • GC07P094540

Summaries for SPDYE3 Gene

GeneCards Summary for SPDYE3 Gene

SPDYE3 (Speedy/RINGO Cell Cycle Regulator Family Member E3) is a Protein Coding gene. Among its related pathways are Oocyte meiosis. An important paralog of this gene is SPDYE6.

Additional gene information for SPDYE3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPDYE3 Gene

Genomics for SPDYE3 Gene

Regulatory Elements for SPDYE3 Gene

Enhancers for SPDYE3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H101159 1.5 Ensembl ENCODE dbSUPER 10 +855.3 855282 5.5 PKNOX1 ARID4B SIN3A GLI4 ZNF121 GLIS2 FOS KLF7 SP3 TSHZ1 AP1S1 SRRT NAT16 PPP1R35 GIGYF1 ZCWPW1 STAG3L5P MEPCE PCOLCE-AS1 RN7SL750P
GH07H101169 1.5 Ensembl ENCODE dbSUPER 10 +863.3 863288 1.2 ATF1 YBX1 GLI4 ZNF2 ZBTB7B GLIS2 ZNF143 RUNX3 SP3 TSHZ1 SRRT PILRB MEPCE PPP1R35 GIGYF1 STAG3L5P TRIP6 FBXO24 ZCWPW1 SPDYE3
GH07H100475 1.4 ENCODE dbSUPER 10.1 +170.9 170943 4.4 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B ZSCAN25 TRIM4 GIGYF1 ZNF3 ZNF655 SRRT AP4M1 ENSG00000242798 STAG3L5P PILRA
GH07H101116 2 FANTOM5 Ensembl ENCODE dbSUPER 4.9 +816.9 816932 15.1 HDGF FOXA2 MLX ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 FOS ENSG00000242798 GIGYF1 SRRT STAG3L5P PCOLCE-AS1 PILRB PPP1R35 SERPINE1 MBLAC1 MEPCE
GH07H100317 0.4 Ensembl 0.4 +10.9 10889 0.6 POLR2A SPDYE3 ENSG00000201913 GC07M100331
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPDYE3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SPDYE3 Gene

Genomic Locations for SPDYE3 Gene
chr7:100,306,812-100,322,196
(GRCh38/hg38)
Size:
15,385 bases
Orientation:
Plus strand
chr7:99,905,325-99,919,819
(GRCh37/hg19)

Genomic View for SPDYE3 Gene

Genes around SPDYE3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPDYE3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPDYE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPDYE3 Gene

Proteins for SPDYE3 Gene

  • Protein details for SPDYE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NKU9-SPDE3_HUMAN
    Recommended name:
    Speedy protein E3
    Protein Accession:
    A6NKU9
    Secondary Accessions:
    • Q495Y9
    • Q6PHC4

    Protein attributes for SPDYE3 Gene

    Size:
    549 amino acids
    Molecular mass:
    63895 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPDYE3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPDYE3 Gene

Post-translational modifications for SPDYE3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPDYE3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPDYE3 Gene

Domains & Families for SPDYE3 Gene

Gene Families for SPDYE3 Gene

Protein Domains for SPDYE3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPDYE3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NKU9

UniProtKB/Swiss-Prot:

SPDE3_HUMAN :
  • Belongs to the Speedy/Ringo family.
Family:
  • Belongs to the Speedy/Ringo family.
genes like me logo Genes that share domains with SPDYE3: view

Function for SPDYE3 Gene

Phenotypes From GWAS Catalog for SPDYE3 Gene

Gene Ontology (GO) - Molecular Function for SPDYE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IBA --
genes like me logo Genes that share ontologies with SPDYE3: view

Phenotypes for SPDYE3 Gene

genes like me logo Genes that share phenotypes with SPDYE3: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPDYE3 Gene

Localization for SPDYE3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPDYE3 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SPDYE3 Gene

Pathways & Interactions for SPDYE3 Gene

SuperPathways for SPDYE3 Gene

SuperPathway Contained pathways
1 Oocyte meiosis
genes like me logo Genes that share pathways with SPDYE3: view

Pathways by source for SPDYE3 Gene

Interacting Proteins for SPDYE3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000329565%0d%0a9606.ENSP00000321656%0d%0a
Selected Interacting proteins: ENSP00000329565 for SPDYE3 Gene via STRING

Symbol External ID(s) Details
CDC25C

Gene Ontology (GO) - Biological Process for SPDYE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045859 regulation of protein kinase activity IBA --
genes like me logo Genes that share ontologies with SPDYE3: view

No data available for SIGNOR curated interactions for SPDYE3 Gene

Drugs & Compounds for SPDYE3 Gene

No Compound Related Data Available

Transcripts for SPDYE3 Gene

mRNA/cDNA for SPDYE3 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPDYE3 Gene

Speedy homolog E3 (Xenopus laevis):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPDYE3 Gene

No ASD Table

Relevant External Links for SPDYE3 Gene

GeneLoc Exon Structure for
SPDYE3
ECgene alternative splicing isoforms for
SPDYE3

Expression for SPDYE3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPDYE3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPDYE3 Gene:

SPDYE3

SOURCE GeneReport for Unigene cluster for SPDYE3 Gene:

Hs.703626

Evidence on tissue expression from TISSUES for SPDYE3 Gene

  • Nervous system(4.3)
  • Blood(3.5)
  • Intestine(3.5)
  • Stomach(3.4)
  • Lung(2.7)
  • Liver(2.5)
genes like me logo Genes that share expression patterns with SPDYE3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPDYE3 Gene

Orthologs for SPDYE3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPDYE3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 81 (a)
OneToMany
-- 34
  • 81 (a)
OneToMany
-- 34
  • 81 (a)
OneToMany
-- 34
  • 81 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 65 (a)
ManyToMany
-- 34
  • 65 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia 4933411G11Rik 34
  • 50 (a)
ManyToMany
Spdyb 34
  • 47 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 49 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 34 (a)
ManyToMany
-- 34
  • 33 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 21 (a)
OneToMany
Species where no ortholog for SPDYE3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPDYE3 Gene

ENSEMBL:
Gene Tree for SPDYE3 (if available)
TreeFam:
Gene Tree for SPDYE3 (if available)

Paralogs for SPDYE3 Gene

Paralogs for SPDYE3 Gene

(9) SIMAP similar genes for SPDYE3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPDYE3: view

Variants for SPDYE3 Gene

Sequence variations from dbSNP and Humsavar for SPDYE3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000234077 -- 100,315,187(+) GACAG(G/T)AGAAT intron-variant
rs1000388372 -- 100,306,028(+) TAAAG(C/T)GTCAT upstream-variant-2KB
rs1000740618 -- 100,305,617(+) ACACC(C/T)AGCTC upstream-variant-2KB
rs1000972591 -- 100,312,891(+) AAAAA(A/G)AGAGG intron-variant
rs1000978959 -- 100,319,238(+) GACAA(A/G)GGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPDYE3 Gene

Variant ID Type Subtype PubMed ID
nsv981559 CNV duplication 23825009
nsv970561 CNV duplication 23825009
nsv967347 CNV duplication 23825009
nsv831071 CNV loss 17160897
nsv8183 CNV gain+loss 18304495
nsv436898 CNV insertion 17901297
nsv428180 CNV gain 18775914
nsv1144193 CNV deletion 24896259
esv3614295 CNV gain 21293372
esv3614293 CNV gain 21293372
esv2734890 CNV deletion 23290073
esv2734888 CNV deletion 23290073
esv26986 CNV gain 19812545
esv1305604 CNV deletion 17803354

Variation tolerance for SPDYE3 Gene

Gene Damage Index Score: 0.27; 6.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPDYE3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPDYE3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPDYE3 Gene

Disorders for SPDYE3 Gene

Relevant External Links for SPDYE3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPDYE3

No disorders were found for SPDYE3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPDYE3 Gene

Publications for SPDYE3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 60
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for SPDYE3 Gene

Sources for SPDYE3 Gene

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