SPDYE3 Gene
protein-coding GIFtS: 33
GCID: GC07P099905
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speedy homolog E3 (Xenopus laevis)
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Aliases
for SPDYE3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Speedy Homolog E3 (Xenopus Laevis)1 2 | | Putative Speedy Protein E32 | | Putative WBSCR19-Like Protein 72 | | Speedy Protein E32 |
Export aliases for SPDYE3 gene to outside databasesPrevious GC identifers: GC07P099744 GC07P094540 |
Summaries
for SPDYE3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
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Genomic Views
for SPDYE3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPDYE3 gene promoter:
RFX1 SREBP-1c Pax-2 Pax-2a Evi-1 E47 SREBP-1b Pax-2b SREBP-1a Hand1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPDYE3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPDYE3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q22.1 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q22.1SPDYE3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P099905: view genomic region
(about GC identifiers)
Start:
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99,905,325 bp from pter |
End:
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99,919,819 bp from pter |
Size:
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14,495 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 99,265,411-99,279,905 |
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Proteins
for SPDYE3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPDE3_HUMAN, A6NKU9 (See
protein sequence)Recommended Name: Speedy protein E3 Size: 549 amino acids; 63895 Da
Secondary accessions: Q495Y9 Q6PHC4Alternative splicing: 2 isoforms: A6NKU9-1 A6NKU9-2 Explore the universe of human proteins at neXtProt for SPDYE3: NX_A6NKU9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A6NKU9
SPDYE3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001004351.3
ENSEMBL proteins: ENSP00000329565 ENSP00000401147
Human Recombinant Protein Products:
SPDYE3 Antibody Products:
Assay Products for SPDYE3: |
Protein
Domains /
Families
for SPDYE3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SPDYE3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry A6NKU9ProtoNet protein and cluster: A6NKU9 UniProtKB/Swiss-Prot: SPDE3_HUMAN, A6NKU9Similarity: Belongs to the Speedy/Ringo family |
Function
for SPDYE3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPDYE3
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPDYE3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SPDYE3 (NM_001004351) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPDYE3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPDYE3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPDYE3 |
|
Pathways & Interactions
for SPDYE3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPDYE3
|
Drugs & Compounds
for SPDYE3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPDYE3
Search CenterWatch for drugs/clinical trials and news about SPDYE3 / SPDE3
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Transcripts
for SPDYE3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPDYE3 gene: NM_001004351.4 Unigene Cluster for SPDYE3: Speedy homolog E3 (Xenopus laevis) Hs.703626 [show with all ESTs]Unigene Representative Sequence: BC0566064 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000332397(uc022aij.1) ENST00000380765 ENST00000489778 ENST00000437326
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPDYE3
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPDYE3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SPDYE3 (NM_001004351) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPDYE3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPDYE3 |
Additional cDNA sequence: BC056606.1 BC100972.2 10 DOTS entries: DT.121100018 DT.121099947 DT.102840647 DT.95087746 DT.75102256 DT.95351439 DT.121100011 DT.216323 DT.95144508 DT.97801724 14 AceView cDNA sequences: AA077752 BC056606 NM_001004351 AA078008 AA078438 AA077194 BF379152 BF810684 BF893680 AW867316 CA443731 BG995765 AW878297 AW578673
GeneLoc Exon Structure
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Expression
for SPDYE3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPDYE3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGACGTGAAT
About this image
See SPDYE3 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.703626
SABiosciences Custom PCR Arrays for SPDYE3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPDYE3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SPDYE3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPDYE3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPDYE3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPDYE3 |
Orthologs
for SPDYE3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for SPDYE3 (if available)
TreeFam Gene Tree for SPDYE3 (if available) |
Paralogs
for SPDYE3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SPDYE3 gene
- SPDYA2 SPDYE42 SPDYC2 SPDYE12 SPDYE2L2 SPDYE22
9 SIMAP similar genes for SPDYE3 using alignment to 1 protein entry: SPDE3_HUMAN:SPDYE7P SPDYE1 SPDYE5 SPDYE4 SPDYB2-L1 SPDYE2
SPDYE2L SPDYE6 SPY1
SPDYE3 for paralogs About GeneDecksing
5/8 Pseudogenes.org Pseudogenes for SPDYE3 (see all 8)
PGOHUM00000250874 PGOHUM00000250875 PGOHUM00000250877 PGOHUM00000250888 PGOHUM00000250947
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Genomic Variants
for SPDYE3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for SPDYE3 (99905325 - 99919819 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for SPDYE3
10 CNVs: 94735 82104 32937 94740 31379 64901 94734 23856 82105 70010 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPDYE3 |
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Disorders
/ Diseases
for SPDYE3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for SPDYE3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPDYE3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SPDYE3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1 Scherer S.W.... Tsui L.-C. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for SPDYE3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SPDYE3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SPDYE3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPDYE3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SPDYE3 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SPDYE3 gene:
Search GeneIP for patents involving SPDYE3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPDYE3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPDYE3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPDYE3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPDYE3 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPDYE3 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPDYE3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPDYE3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SPDYE3 | | OriGene Custom Protein Services for SPDYE3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPDYE3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPDYE3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPDYE3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPDYE3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPDYE3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPDYE3 |
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| | | | Search Tocris compounds for SPDYE3 |
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 | | | SPDYE3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPDYE3 |
|  |  |  | | | | ThermoFisher Antibody for SPDYE3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPDYE3 |
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