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Aliases for SPDYE2 Gene

Aliases for SPDYE2 Gene

  • Speedy/RINGO Cell Cycle Regulator Family Member E2 2 3 5
  • Speedy Homolog E2 (Xenopus Laevis) 2
  • Putative Speedy Protein E2 3
  • Speedy Homolog E2 3
  • Speedy B2-Like 1 3
  • SPDYB2-L1 3

External Ids for SPDYE2 Gene

Previous GeneCards Identifiers for SPDYE2 Gene

  • GC07P101985
  • GC07P102191
  • GC07M096582

Summaries for SPDYE2 Gene

GeneCards Summary for SPDYE2 Gene

SPDYE2 (Speedy/RINGO Cell Cycle Regulator Family Member E2) is a Protein Coding gene. Among its related pathways are Oocyte meiosis. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is SPDYE2B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPDYE2 Gene

Genomics for SPDYE2 Gene

Regulatory Elements for SPDYE2 Gene

Enhancers for SPDYE2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SPDYE2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPDYE2 Gene

Chromosome:
7
Start:
102,550,749 bp from pter
End:
102,562,633 bp from pter
Size:
11,885 bases
Orientation:
Plus strand

Genomic View for SPDYE2 Gene

Genes around SPDYE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPDYE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPDYE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPDYE2 Gene

Proteins for SPDYE2 Gene

  • Protein details for SPDYE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q495Y8-SPDE2_HUMAN
    Recommended name:
    Speedy protein E2
    Protein Accession:
    Q495Y8
    Secondary Accessions:
    • B4DY11

    Protein attributes for SPDYE2 Gene

    Size:
    402 amino acids
    Molecular mass:
    48300 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPDYE2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPDYE2 Gene

Proteomics data for SPDYE2 Gene at MOPED

Post-translational modifications for SPDYE2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPDYE2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPDYE2 Gene

Domains & Families for SPDYE2 Gene

Gene Families for SPDYE2 Gene

Protein Domains for SPDYE2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPDYE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q495Y8

UniProtKB/Swiss-Prot:

SPDE2_HUMAN :
  • Belongs to the Speedy/Ringo family.
Family:
  • Belongs to the Speedy/Ringo family.
genes like me logo Genes that share domains with SPDYE2: view

Function for SPDYE2 Gene

Phenotypes for SPDYE2 Gene

GenomeRNAi human phenotypes for SPDYE2:
genes like me logo Genes that share phenotypes with SPDYE2: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPDYE2 Gene

Localization for SPDYE2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPDYE2 Gene COMPARTMENTS Subcellular localization image for SPDYE2 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SPDYE2 Gene

Pathways & Interactions for SPDYE2 Gene

SuperPathways for SPDYE2 Gene

genes like me logo Genes that share pathways with SPDYE2: view

Pathways by source for SPDYE2 Gene

Interacting Proteins for SPDYE2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000421686%0d%0a9606.ENSP00000364721%0d%0a
Selected Interacting proteins: Q495Y8-SPDE2_HUMAN ENSP00000421686 for SPDYE2 Gene via UniProtKB STRING

Gene Ontology (GO) - Biological Process for SPDYE2 Gene

None

No data available for SIGNOR curated interactions for SPDYE2 Gene

Drugs & Compounds for SPDYE2 Gene

No Compound Related Data Available

Transcripts for SPDYE2 Gene

mRNA/cDNA for SPDYE2 Gene

(5) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPDYE2 Gene

Speedy homolog E2 (Xenopus laevis):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPDYE2 Gene

No ASD Table

Relevant External Links for SPDYE2 Gene

GeneLoc Exon Structure for
SPDYE2
ECgene alternative splicing isoforms for
SPDYE2

Expression for SPDYE2 Gene

mRNA expression in normal human tissues for SPDYE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPDYE2 Gene

This gene is overexpressed in Testis (x10.0).

SOURCE GeneReport for Unigene cluster for SPDYE2 Gene Hs.656428

genes like me logo Genes that share expression patterns with SPDYE2: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SPDYE2 Gene

Orthologs for SPDYE2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPDYE2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 36
  • 49 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 66 (a)
ManyToMany
-- 36
  • 66 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 52 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia 4933411G11Rik 36
  • 49 (a)
ManyToMany
Spdyb 36
  • 48 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 33 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 90 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
OneToMany
Species with no ortholog for SPDYE2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPDYE2 Gene

ENSEMBL:
Gene Tree for SPDYE2 (if available)
TreeFam:
Gene Tree for SPDYE2 (if available)

Paralogs for SPDYE2 Gene

Paralogs for SPDYE2 Gene

(9) SIMAP similar genes for SPDYE2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SPDYE2 Gene

genes like me logo Genes that share paralogs with SPDYE2: view

Variants for SPDYE2 Gene

Structural Variations from Database of Genomic Variants (DGV) for SPDYE2 Gene

Variant ID Type Subtype PubMed ID
nsv428182 CNV Gain 18775914
nsv831083 CNV Loss 17160897
dgv7412n71 CNV Loss 21882294
nsv5879 CNV Loss 18451855
nsv8192 CNV Gain 18304495
esv27624 CNV Gain+Loss 19812545
nsv888836 CNV Loss 21882294
dgv7414n71 CNV Gain+Loss 21882294
dgv7415n71 CNV Gain+Loss 21882294
dgv7416n71 CNV Gain 21882294
dgv7417n71 CNV Gain 21882294
nsv888845 CNV Gain 21882294
dgv23n31 CNV Duplication 19718026
nsv499529 CNV Loss 21111241
nsv433392 CNV Gain 18776910
nsv436086 CNV Insertion 17901297
nsv436552 CNV Deletion 17901297
dgv7418n71 CNV Gain 21882294
esv2734946 CNV Deletion 23290073
nsv888865 CNV Loss 21882294
dgv7419n71 CNV Loss 21882294
dgv7420n71 CNV Gain 21882294
esv7079 CNV Loss 19470904
nsv888868 CNV Loss 21882294
dgv7421n71 CNV Gain+Loss 21882294
nsv888872 CNV Gain+Loss 21882294
nsv469682 CNV Complex 16826518
nsv471643 CNV Gain+Loss 15918152
nsv509219 CNV Insertion 20534489
dgv7423n71 CNV Loss 21882294
nsv888877 CNV Loss 21882294
dgv7424n71 CNV Gain 21882294
nsv9 CNV Loss 15895083
nsv499135 CNV Loss 21111241
dgv7428n71 CNV Gain+Loss 21882294
dgv7430n71 CNV Gain+Loss 21882294
dgv7431n71 CNV Loss 21882294
dgv7432n71 CNV Loss 21882294
nsv888907 CNV Gain+Loss 21882294
dgv7433n71 CNV Loss 21882294
dgv7435n71 CNV Gain 21882294
nsv888921 CNV Gain 21882294
nsv482113 CNV Gain 20164927
nsv469620 CNV Loss 16826518

Variation tolerance for SPDYE2 Gene

Gene Damage Index Score: 0.09; 1.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPDYE2 Gene

HapMap Linkage Disequilibrium report
SPDYE2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for SPDYE2 Gene

Disorders for SPDYE2 Gene

Relevant External Links for SPDYE2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPDYE2

No disorders were found for SPDYE2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPDYE2 Gene

Publications for SPDYE2 Gene

  1. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 67
  2. Evolution of the Cdk-activator Speedy/RINGO in vertebrates. (PMID: 22763696) Chauhan S. … Kaldis P. (Cell. Mol. Life Sci. 2012) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PMID: 10737800) Dias Neto E. … Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3

Products for SPDYE2 Gene

Sources for SPDYE2 Gene

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