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Aliases for SPDYE2 Gene

Aliases for SPDYE2 Gene

  • Speedy/RINGO Cell Cycle Regulator Family Member E2 2 3
  • Speedy Homolog E2 (Xenopus Laevis) 2
  • Putative Speedy Protein E2 3
  • Speedy Homolog E2 3
  • Speedy Protein E2 3
  • Speedy B2-Like 1 3
  • SPDYB2-L1 3

External Ids for SPDYE2 Gene

Summaries for SPDYE2 Gene

GeneCards Summary for SPDYE2 Gene

SPDYE2 (Speedy/RINGO Cell Cycle Regulator Family Member E2) is a Protein Coding gene. An important paralog of this gene is SPDYE3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPDYE2 Gene

Genomics for SPDYE2 Gene

Genomic Location for SPDYE2 Gene

Start:
102,551,232 bp from pter
End:
102,563,876 bp from pter
Size:
12,645 bases
Orientation:
Plus strand

Genomic View for SPDYE2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPDYE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPDYE2 Gene

Regulatory Elements for SPDYE2 Gene

Proteins for SPDYE2 Gene

  • Protein details for SPDYE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q495Y8-SPDE2_HUMAN
    Recommended name:
    Speedy protein E2
    Protein Accession:
    Q495Y8
    Secondary Accessions:
    • B4DY11

    Protein attributes for SPDYE2 Gene

    Size:
    402 amino acids
    Molecular mass:
    48300 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPDYE2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPDYE2 Gene

Proteomics data for SPDYE2 Gene at MOPED

Post-translational modifications for SPDYE2 Gene

No Post-translational modifications

Other Protein References for SPDYE2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPDYE2 Gene

Domains for SPDYE2 Gene

Gene Families for SPDYE2 Gene

HGNC:
  • SPDY :Speedy homologs

Protein Domains for SPDYE2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

SPDE2_HUMAN
Family:
  • Belongs to the Speedy/Ringo family.:
    • Q495Y8
genes like me logo Genes that share domains with SPDYE2: view

Function for SPDYE2 Gene

Gene Ontology (GO) - Molecular Function for SPDYE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0019901 protein kinase binding IBA --
genes like me logo Genes that share ontologies with SPDYE2: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SPDYE2 Gene

Localization for SPDYE2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPDYE2 Gene COMPARTMENTS Subcellular localization image for SPDYE2 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for SPDYE2 Gene

Pathways for SPDYE2 Gene

SuperPathways for SPDYE2 Gene

No Data Available

Interacting Proteins for SPDYE2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000421686%0d%0a9606.ENSP00000364721%0d%0a
Selected Interacting proteins: ENSP00000421686 Q495Y8-SPDE2_HUMAN for SPDYE2 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for SPDYE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045859 regulation of protein kinase activity IBA --
genes like me logo Genes that share ontologies with SPDYE2: view

No data available for Pathways by source for SPDYE2 Gene

Transcripts for SPDYE2 Gene

mRNA/cDNA for SPDYE2 Gene

(5) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPDYE2 Gene

Speedy homolog E2 (Xenopus laevis):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPDYE2 Gene

No ASD Table

Relevant External Links for SPDYE2 Gene

GeneLoc Exon Structure for
SPDYE2
ECgene alternative splicing isoforms for
SPDYE2

Expression for SPDYE2 Gene

mRNA expression in normal human tissues for SPDYE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPDYE2 Gene

This gene is overexpressed in Testis (10.0).

SOURCE GeneReport for Unigene cluster for SPDYE2 Gene Hs.656428

genes like me logo Genes that share expressions with SPDYE2: view

Orthologs for SPDYE2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPDYE2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 90 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 37
  • 49 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 66 (a)
ManyToMany
-- 37
  • 66 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia 4933411G11Rik 37
  • 49 (a)
ManyToMany
Spdyb 37
  • 48 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 52 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 33 (a)
ManyToMany
-- 37
  • 34 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 20 (a)
OneToMany
Species with no ortholog for SPDYE2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPDYE2 Gene

ENSEMBL:
Gene Tree for SPDYE2 (if available)
TreeFam:
Gene Tree for SPDYE2 (if available)

Paralogs for SPDYE2 Gene

Paralogs for SPDYE2 Gene

Selected SIMAP similar genes for SPDYE2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SPDYE2 Gene

genes like me logo Genes that share paralogs with SPDYE2: view

Variants for SPDYE2 Gene

Structural Variations from Database of Genomic Variants (DGV) for SPDYE2 Gene

Variant ID Type Subtype PubMed ID
nsv428182 CNV Gain 18775914
nsv831083 CNV Loss 17160897
dgv7412n71 CNV Loss 21882294
nsv5879 CNV Loss 18451855
nsv8192 CNV Gain 18304495
esv27624 CNV Gain+Loss 19812545
nsv888836 CNV Loss 21882294
dgv7414n71 CNV Gain+Loss 21882294
dgv7415n71 CNV Gain+Loss 21882294
dgv7416n71 CNV Gain 21882294
dgv7417n71 CNV Gain 21882294
nsv888845 CNV Gain 21882294
dgv23n31 CNV Duplication 19718026
nsv499529 CNV Loss 21111241
nsv433392 CNV Gain 18776910
nsv436086 CNV Insertion 17901297
nsv436552 CNV Deletion 17901297
dgv7418n71 CNV Gain 21882294
esv2734946 CNV Deletion 23290073
nsv888865 CNV Loss 21882294
dgv7419n71 CNV Loss 21882294
dgv7420n71 CNV Gain 21882294
esv7079 CNV Loss 19470904
nsv888868 CNV Loss 21882294
dgv7421n71 CNV Gain+Loss 21882294
nsv888872 CNV Gain+Loss 21882294
nsv469682 CNV Complex 16826518
nsv471643 CNV Gain+Loss 15918152
nsv509219 CNV Insertion 20534489
dgv7423n71 CNV Loss 21882294
nsv888877 CNV Loss 21882294
dgv7424n71 CNV Gain 21882294
nsv9 CNV Loss 15895083
nsv499135 CNV Loss 21111241
dgv7428n71 CNV Gain+Loss 21882294
dgv7430n71 CNV Gain+Loss 21882294
dgv7431n71 CNV Loss 21882294
dgv7432n71 CNV Loss 21882294
nsv888907 CNV Gain+Loss 21882294
dgv7433n71 CNV Loss 21882294
dgv7435n71 CNV Gain 21882294
nsv888921 CNV Gain 21882294
nsv482113 CNV Gain 20164927
nsv469620 CNV Loss 16826518

Relevant External Links for SPDYE2 Gene

HapMap Linkage Disequilibrium report
SPDYE2

No data available for Sequence variations from dbSNP and Humsavar for SPDYE2 Gene

Disorders for SPDYE2 Gene

No disorders were found for SPDYE2 Gene.

No data available for UniProtKB/Swiss-Prot for SPDYE2 Gene

Publications for SPDYE2 Gene

  1. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PMID: 10737800) Dias Neto E. … Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Evolution of the Cdk-activator Speedy/RINGO in vertebrates. (PMID: 22763696) Chauhan S. … Kaldis P. (Cell. Mol. Life Sci. 2012) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 4

Products for SPDYE2 Gene

Sources for SPDYE2 Gene

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