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SPDYE2 Gene

protein-coding   GIFtS: 32
GCID: GC07P102191

Speedy/RINGO Cell Cycle Regulator Family Member E2

(Previous name: speedy homolog E2 (Xenopus laevis))
  Search for SPDYE2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Speedy/RINGO Cell Cycle Regulator Family Member E21 2     Speedy B2-Like 12
Speedy Homolog E2 (Xenopus Laevis)1     Speedy Homolog E22
SPDYB2-L12     Speedy Protein E22
Putative Speedy Protein E22     

External Ids:    HGNC: 338411   Entrez Gene: 4412732   Ensembl: ENSG000002052387   UniProtKB: Q495Y83   

Export aliases for SPDYE2 gene to outside databases

Previous GC identifers: GC07P101985 GC07M096582


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SPDYE2 Gene:
SPDYE2 (speedy/RINGO cell cycle regulator family member E2) is a protein-coding gene. An important paralog of this gene is SPDYE2B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPDYE2 gene promoter:
         RFX1   Tal-1   p53   AML1a   SREBP-1c   SREBP-1b   Evi-1   AREB6   SREBP-1a   SEF-1 (1)   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPDYE2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

SPDYE2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPDYE2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P102191:  view genomic region     (about GC identifiers)

Start:
102,191,679 bp from pter      End:
102,202,757 bp from pter
Size:
11,079 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 101,552,074-101,563,151     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SPDE2_HUMAN, Q495Y8 (See protein sequence)
Recommended Name: Speedy protein E2  
Size: 402 amino acids; 48300 Da
Secondary accessions: B4DY11
Alternative splicing: 2 isoforms:  Q495Y8-1   Q495Y8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SPDYE2: NX_Q495Y8

Explore proteomics data for SPDYE2 at MOPED


See SPDYE2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001026789.2  
ENSEMBL proteins: 
 ENSP00000421686   ENSP00000342628   ENSP00000395689  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
SPDY: Speedy homologs

1 InterPro protein domain:
 IPR020984 Cell_cycle_regulatory_Spy1

Graphical View of Domain Structure for InterPro Entry Q495Y8

ProtoNet protein and cluster: Q495Y8

UniProtKB/Swiss-Prot: SPDE2_HUMAN, Q495Y8
Similarity: Belongs to the Speedy/Ringo family


SPDYE2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPDYE2
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3
cytosol2

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPDYE2
Interactions:

    Search GeneGlobe Interaction Network for SPDYE2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for SPDYE2 (SPDE2)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for SPDYE2 gene: 
NM_001031618.3  

Unigene Cluster for SPDYE2:

Speedy homolog E2 (Xenopus laevis)
Hs.656428  [show with all ESTs]
Unigene Representative Sequence: NM_001146210
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000507918(uc011kkx.2) ENST00000341656 ENST00000432940
miRNA
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Additional mRNA sequence: 

AK096084.1 AK302217.1 BC100973.1 JQ023160.1 

15 DOTS entries:

DT.100813174  DT.95081870  DT.92469765  DT.121040225  DT.121040300  DT.95202758  DT.437901  DT.121116988 
DT.91859702  DT.102843969  DT.111122  DT.121040496  DT.121124699  DT.40239389  DT.92430851 

2 AceView cDNA sequences:

BI009552 BF333800 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SPDYE2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGCTGCAGGG
SPDYE2 Expression
About this image


SPDYE2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Adipose (Muscoskeletal System)
         Mesenchymal Stem Cells Subcutaneous White Adipose
 
 Mesenchymal Stem Cells
         Mesenchymal Stem Cells Subcutaneous White Adipose
SPDYE2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SPDYE2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.656428
    Custom PCR Arrays for SPDYE2
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPDYE2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

ENSEMBL Gene Tree for SPDYE2 (if available)
TreeFam Gene Tree for SPDYE2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SPDYE2 gene
SPDYE2B1 2  SPDYE6  SPDYE42  SPDYA2  SPDYC2  SPDYE12  SPDYE32  
9 SIMAP similar genes for SPDYE2 using alignment to 1 protein entry:     SPDE2_HUMAN:
SPDYB2-L1    SPDYE2B    SPDYE6    SPDYE1    SPDYE5    SPDYE7P
SPDYE3    SPY1    SPDYE4

SPDYE2 for paralogs           About GeneDecksing


2 Pseudogenes.org Pseudogenes for SPDYE2
PGOHUM00000260198 PGOHUM00000233210


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Structural Variations
     Database of Genomic Variants (DGV) Selected variations for SPDYE2 (see all 44):    About this table    
Variant IDTypeSubtypePubMed ID
nsv436552CNV Deletion17901297
esv2734946CNV Deletion23290073
dgv23n31CNV Duplication19718026
nsv509219CNV Insertion20534489
nsv436086CNV Insertion17901297
nsv5879CNV Loss18451855
nsv888877CNV Loss21882294
nsv469620CNV Loss16826518
dgv7412n71CNV Loss21882294
nsv888836CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SPDYE2 gene integrated from 10 sources:
(articles sorted by number of sources associating them with SPDYE2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Evolution of the Cdk-activator Speedy/RINGO in vertebrates. (PubMed id 22763696)1 Chauhan S....Kaldis P. (Cell. Mol. Life Sci. 2012)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (Nature 2003)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  6. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 441273 HGNC: 33841 AceView: LOC441273 Ensembl:ENSG00000205238 euGenes: HUgn441273
ECgene: SPDYE2 H-InvDB: SPDYE2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for SPDYE2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SPDYE2 gene:
Search GeneIP for patents involving SPDYE2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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