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Aliases for SPDYE2 Gene

Aliases for SPDYE2 Gene

  • Speedy/RINGO Cell Cycle Regulator Family Member E2 2 3 5
  • Speedy Homolog E2 (Xenopus Laevis) 2
  • Putative Speedy Protein E2 3
  • Speedy Homolog E2 3
  • Speedy Protein E2 3
  • Speedy B2-Like 1 3
  • SPDYB2-L1 3

External Ids for SPDYE2 Gene

Previous GeneCards Identifiers for SPDYE2 Gene

  • GC07P101985
  • GC07P102191
  • GC07M096582

Summaries for SPDYE2 Gene

GeneCards Summary for SPDYE2 Gene

SPDYE2 (Speedy/RINGO Cell Cycle Regulator Family Member E2) is a Protein Coding gene. Among its related pathways are Oocyte meiosis. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is SPDYE2B.

Additional gene information for SPDYE2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPDYE2 Gene

Genomics for SPDYE2 Gene

GeneHancer (GH) Regulatory Elements for SPDYE2 Gene

Promoters and enhancers for SPDYE2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I102551 Promoter 0.5 EPDnew 550.8 +0.5 509 0.1 SPDYE2 PIR51443 POLR2J3 ENSG00000270249
GH07I102748 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 17.9 +198.4 198367 1.8 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A ZNF2 YY1 POLR2B E2F8 FAM185A POLR2J2 RASA4DP SPDYE2 RASA4 DNAJC2 ARMC10 FBXL13 CRYZP1 ENSG00000213385
GH07I102463 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.3 -85.7 -85696 2.1 HDGF PKNOX1 ARID4B SIN3A ZBTB7B YY1 POLR2B ZNF766 E2F8 ZNF207 ALKBH4 GC07P102467 MIR5090 PIR43748 LRWD1 ENSG00000272949 POLR2J ORAI2 SPDYE2 RASA4DP
GH07I102972 Enhancer 1.4 Ensembl ENCODE dbSUPER 12.2 +422.9 422879 3.2 HDGF PKNOX1 SMAD1 ARNT YBX1 ZBTB7B POLR2B E2F8 REST ZNF592 NFE4 CRYZP1 ENSG00000213385 SPDYE2 DNAJC2 PMPCB FBXL13 ARMC10 RPL23AP95 GC07P103004
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPDYE2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPDYE2 gene promoter:

Genomic Locations for SPDYE2 Gene

Genomic Locations for SPDYE2 Gene
11,885 bases
Plus strand

Genomic View for SPDYE2 Gene

Genes around SPDYE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPDYE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPDYE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPDYE2 Gene

Proteins for SPDYE2 Gene

  • Protein details for SPDYE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Speedy protein E2
    Protein Accession:
    Secondary Accessions:
    • B4DY11

    Protein attributes for SPDYE2 Gene

    402 amino acids
    Molecular mass:
    48300 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPDYE2 Gene


neXtProt entry for SPDYE2 Gene

Post-translational modifications for SPDYE2 Gene

No Post-translational modifications

Other Protein References for SPDYE2 Gene

No data available for DME Specific Peptides for SPDYE2 Gene

Domains & Families for SPDYE2 Gene

Gene Families for SPDYE2 Gene

Protein Domains for SPDYE2 Gene


Suggested Antigen Peptide Sequences for SPDYE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Speedy/Ringo family.
  • Belongs to the Speedy/Ringo family.
genes like me logo Genes that share domains with SPDYE2: view

Function for SPDYE2 Gene

Gene Ontology (GO) - Molecular Function for SPDYE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0019901 protein kinase binding IBA --
genes like me logo Genes that share ontologies with SPDYE2: view

Phenotypes for SPDYE2 Gene

GenomeRNAi human phenotypes for SPDYE2:
genes like me logo Genes that share phenotypes with SPDYE2: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPDYE2 Gene

Localization for SPDYE2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPDYE2 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SPDYE2 Gene

Pathways & Interactions for SPDYE2 Gene

SuperPathways for SPDYE2 Gene

SuperPathway Contained pathways
1 Oocyte meiosis
genes like me logo Genes that share pathways with SPDYE2: view

Pathways by source for SPDYE2 Gene

Interacting Proteins for SPDYE2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000421686 Q495Y8-SPDE2_HUMAN for SPDYE2 Gene via STRING UniProtKB IID

Gene Ontology (GO) - Biological Process for SPDYE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045859 regulation of protein kinase activity IBA --
genes like me logo Genes that share ontologies with SPDYE2: view

No data available for SIGNOR curated interactions for SPDYE2 Gene

Drugs & Compounds for SPDYE2 Gene

No Compound Related Data Available

Transcripts for SPDYE2 Gene

mRNA/cDNA for SPDYE2 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPDYE2 Gene

Speedy homolog E2 (Xenopus laevis):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPDYE2 Gene

No ASD Table

Relevant External Links for SPDYE2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPDYE2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPDYE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPDYE2 Gene

This gene is overexpressed in Testis (x10.0).

NURSA nuclear receptor signaling pathways regulating expression of SPDYE2 Gene:


SOURCE GeneReport for Unigene cluster for SPDYE2 Gene:


Evidence on tissue expression from TISSUES for SPDYE2 Gene

  • Nervous system(2)
genes like me logo Genes that share expression patterns with SPDYE2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPDYE2 Gene

Orthologs for SPDYE2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPDYE2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 90 (a)
(Canis familiaris)
Mammalia -- 34
  • 66 (a)
-- 34
  • 66 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 52 (a)
(Bos Taurus)
Mammalia -- 34
  • 49 (a)
(Mus musculus)
Mammalia 4933411G11Rik 34
  • 49 (a)
Spdyb 34
  • 48 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 34 (a)
-- 34
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 20 (a)
Species where no ortholog for SPDYE2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPDYE2 Gene

Gene Tree for SPDYE2 (if available)
Gene Tree for SPDYE2 (if available)

Paralogs for SPDYE2 Gene

Paralogs for SPDYE2 Gene

(9) SIMAP similar genes for SPDYE2 Gene using alignment to 1 proteins: Pseudogenes for SPDYE2 Gene

genes like me logo Genes that share paralogs with SPDYE2: view

Variants for SPDYE2 Gene

Sequence variations from dbSNP and Humsavar for SPDYE2 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1002471973 -- 102,550,291(+) G/C upstream_transcript_variant
rs1002503265 -- 102,554,940(+) C/T intron_variant
rs1005063621 -- 102,549,933(+) T/C upstream_transcript_variant
rs1011487240 -- 102,550,573(+) T/C/G upstream_transcript_variant
rs1011929442 -- 102,555,405(+) G/A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SPDYE2 Gene

Variant ID Type Subtype PubMed ID
dgv11541n54 CNV loss 21841781
dgv11542n54 CNV loss 21841781
dgv11543n54 CNV loss 21841781
dgv11544n54 CNV loss 21841781
dgv11545n54 CNV loss 21841781
dgv11548n54 CNV loss 21841781
dgv11550n54 CNV loss 21841781
dgv1944e212 CNV loss 25503493
dgv23n31 CNV gain 19718026
dgv3894e59 CNV duplication 20981092
dgv3899e59 CNV duplication 20981092
dgv3900e59 CNV duplication 20981092
dgv3904e59 CNV duplication 20981092
dgv3906e59 CNV duplication 20981092
dgv6538n100 CNV gain 25217958
dgv6539n100 CNV gain 25217958
dgv6540n100 CNV gain 25217958
dgv6541n100 CNV gain 25217958
esv2734946 CNV deletion 23290073
esv27624 CNV gain+loss 19812545
esv2764015 CNV loss 21179565
esv3327844 CNV duplication 20981092
esv3335589 CNV duplication 20981092
esv3343524 CNV duplication 20981092
esv3377591 CNV duplication 20981092
esv3400561 CNV duplication 20981092
esv3424897 CNV duplication 20981092
esv3891168 CNV gain+loss 25118596
esv3891169 CNV gain+loss 25118596
esv3891171 CNV loss 25118596
esv7079 CNV loss 19470904
nsv1027221 CNV loss 25217958
nsv1034233 CNV loss 25217958
nsv1110493 CNV duplication 24896259
nsv1119231 CNV duplication 24896259
nsv1139905 CNV duplication 24896259
nsv1149718 CNV duplication 26484159
nsv428182 CNV gain 18775914
nsv433392 CNV gain 18776910
nsv436086 CNV insertion 17901297
nsv436552 CNV deletion 17901297
nsv469620 CNV loss 16826518
nsv469682 CNV gain+loss 16826518
nsv471643 CNV gain+loss 15918152
nsv482113 CNV gain 20164927
nsv499135 CNV loss 21111241
nsv499529 CNV loss 21111241
nsv509219 CNV insertion 20534489
nsv5879 CNV deletion 18451855
nsv608005 CNV gain 21841781
nsv608046 CNV loss 21841781
nsv608054 CNV loss 21841781
nsv608055 CNV gain 21841781
nsv8192 CNV gain 18304495
nsv831083 CNV loss 17160897
nsv9 CNV deletion 15895083
nsv967349 CNV duplication 23825009
nsv970562 CNV duplication 23825009
nsv970563 CNV duplication 23825009
nsv970921 CNV duplication 23825009
nsv981562 CNV duplication 23825009
nsv981563 CNV duplication 23825009
nsv981678 CNV duplication 23825009

Variation tolerance for SPDYE2 Gene

Gene Damage Index Score: 0.09; 1.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPDYE2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPDYE2 Gene

Disorders for SPDYE2 Gene

Additional Disease Information for SPDYE2

No disorders were found for SPDYE2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPDYE2 Gene

Publications for SPDYE2 Gene

  1. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  2. Evolution of the Cdk-activator Speedy/RINGO in vertebrates. (PMID: 22763696) Chauhan S … Kaldis P (Cellular and molecular life sciences : CMLS 2012) 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 4 58

Products for SPDYE2 Gene

Sources for SPDYE2 Gene

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