SPDYE2 Gene
protein-coding GIFtS: 35
GCID: GC07P102191
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speedy homolog E2 (Xenopus laevis)
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Aliases
for SPDYE2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Speedy Homolog E2 (Xenopus Laevis)1 2 | | MGC1192951 | | SPDYB2-L12 | | Putative Speedy Protein E22 | | Speedy B2-Like 12 | | Speedy Protein E22 |
Export aliases for SPDYE2 gene to outside databasesPrevious GC identifers: GC07P101985 GC07M096582 |
Summaries
for SPDYE2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
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Genomic Views
for SPDYE2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NT_007933.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPDYE2 gene promoter:
RFX1 Tal-1 p53 AML1a SREBP-1c SREBP-1b Evi-1 AREB6 SREBP-1a SEF-1 (1)
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPDYE2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPDYE2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q22.1 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q22.1SPDYE2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P102191: view genomic region
(about GC identifiers)
Start:
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102,191,679 bp from pter |
End:
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102,202,757 bp from pter |
Size:
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11,079 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 101,651,141-101,662,216 |
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Proteins
for SPDYE2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPDE2_HUMAN, Q495Y8 (See
protein sequence)Recommended Name: Speedy protein E2 Size: 402 amino acids; 48300 Da
Secondary accessions: B4DY11Alternative splicing: 2 isoforms: Q495Y8-1 Q495Y8-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SPDYE2: NX_Q495Y8
SPDYE2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001026789.2
ENSEMBL proteins: ENSP00000421686 ENSP00000342628 ENSP00000395689
Human Recombinant Protein Products:
SPDYE2 Antibody Products:
Assay Products for SPDYE2: |
Protein
Domains /
Families
for SPDYE2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SPDYE2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q495Y8ProtoNet protein and cluster: Q495Y8 UniProtKB/Swiss-Prot: SPDE2_HUMAN, Q495Y8Similarity: Belongs to the Speedy/Ringo family |
Function
for SPDYE2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPDYE2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPDYE2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SPDYE2 (NM_001031618) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPDYE2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPDYE2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPDYE2 |
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Pathways & Interactions
for SPDYE2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPDYE2
|
Drugs & Compounds
for SPDYE2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPDYE2
Search CenterWatch for drugs/clinical trials and news about SPDYE2 / SPDE2
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Transcripts
for SPDYE2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPDYE2 gene: NM_001031618.3 Unigene Cluster for SPDYE2: Speedy homolog E2 (Xenopus laevis) Hs.656428 [show with all ESTs]Unigene Representative Sequence: NM_0011462103 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000507918(uc011kkx.2) ENST00000341656 ENST00000432940
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPDYE2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPDYE2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SPDYE2 (NM_001031618) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPDYE2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPDYE2 |
Additional cDNA sequence: AK096084.1 AK302217.1 BC100973.1 JQ023160.1 15 DOTS entries: DT.100813174 DT.95081870 DT.92469765 DT.121040225 DT.121040300 DT.95202758 DT.437901 DT.121116988 DT.91859702 DT.102843969 DT.111122 DT.121040496 DT.121124699 DT.40239389 DT.92430851 2 AceView cDNA sequences: BI009552 BF333800
GeneLoc Exon Structure
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Expression
for SPDYE2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPDYE2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCTGCAGGG
About this image
See SPDYE2 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.656428
SABiosciences Custom PCR Arrays for SPDYE2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPDYE2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SPDYE2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPDYE2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPDYE2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPDYE2 |
Orthologs
for SPDYE2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for SPDYE2 (if available)
TreeFam Gene Tree for SPDYE2 (if available) |
Paralogs
for SPDYE2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SPDYE2 gene
- SPDYE2L1 2 SPDYE6 SPDYA2 SPDYE42 SPDYC2 SPDYE12 SPDYE32
9 SIMAP similar genes for SPDYE2 using alignment to 1 protein entry: SPDE2_HUMAN:SPDYB2-L1 SPDYE2L SPDYE6 SPDYE1 SPDYE5 SPDYE7P
SPDYE3 SPY1 SPDYE4
SPDYE2 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for SPDYE2
PGOHUM00000260198 PGOHUM00000233210
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Genomic Variants
for SPDYE2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for SPDYE2 (102191679 - 102202757 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 26 variations for SPDYE2
15/26 CNVs (see all 26): 2105 22940 36591 36594 70020 36595 36588 36585 82125 0618 4553 82122 2106 0724 36593 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for SPDYE2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for SPDYE2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPDYE2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SPDYE2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Evolution of the Cdk-activator Speedy/RINGO in vertebr ates. (PubMed id 22763696)1 Chauhan S....Kaldis P. (2012)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (2000)
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External Searches for SPDYE2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SPDYE2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SPDYE2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPDYE2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SPDYE2 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for SPDYE2 gene:
Search GeneIP for patents involving SPDYE2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPDYE2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPDYE2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPDYE2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPDYE2 | | | OriGene Protein Over-expression Lysate for SPDYE2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPDYE2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPDYE2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPDYE2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SPDYE2 | | OriGene Custom Protein Services for SPDYE2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPDYE2 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPDYE2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPDYE2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPDYE2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPDYE2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPDYE2 |
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 |  |  |  | |
| | | | Search Tocris compounds for SPDYE2 |
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 | | | SPDYE2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPDYE2 |
|  |  |  | | | | Search ThermoFisher Antibodies for SPDYE2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPDYE2 |
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