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Aliases for SPDYE2 Gene

Aliases for SPDYE2 Gene

  • Speedy/RINGO Cell Cycle Regulator Family Member E2 2 3 5
  • Speedy Homolog E2 (Xenopus Laevis) 2
  • Putative Speedy Protein E2 3
  • Speedy Homolog E2 3
  • Speedy Protein E2 3
  • Speedy B2-Like 1 3
  • SPDYB2-L1 3

External Ids for SPDYE2 Gene

Previous GeneCards Identifiers for SPDYE2 Gene

  • GC07P101985
  • GC07P102191
  • GC07M096582

Summaries for SPDYE2 Gene

GeneCards Summary for SPDYE2 Gene

SPDYE2 (Speedy/RINGO Cell Cycle Regulator Family Member E2) is a Protein Coding gene. Among its related pathways are Oocyte meiosis. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is SPDYE2B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPDYE2 Gene

Genomics for SPDYE2 Gene

Regulatory Elements for SPDYE2 Gene

Enhancers for SPDYE2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F102572 0.2 ENCODE 12.3 +21.9 21932 1.2 CREB3L1 SIN3A FEZF1 ZNF2 ZNF416 ZNF143 ZNF207 SP3 REST ZFP41 CRYZP1 ENSG00000213385 FAM185A PMPCB ENSG00000236226 S100A11P1 LRWD1 SPDYE2 ENSG00000239486 UPK3BL
GH07F102931 0.4 ENCODE 12 +381.2 381220 0.2 CREB3L1 SIN3A FEZF1 ZNF2 ZNF143 ZNF416 ZNF207 SP3 REST ZFP41 CRYZP1 ENSG00000239486 ENSG00000236226 S100A11P1 PMPCB LRWD1 FAM185A SPDYE2 PRKRIP1 FBXL13
GH07F102008 1.3 Ensembl ENCODE 10 -541.5 -541493 1.7 SIN3A CEBPG RAD21 E2F1 GATA3 CTBP1 HSF1 RCOR1 STAT1 ZNF687 CUX1 SPDYE2 RASA4DP GC07M102004 GC07M101947
GH07F101608 0.6 ENCODE 10 -941.8 -941838 1.0 PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 GIGYF1 MIR6875 SPDYE2 EPHB4 GC07P101590 MYL10
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SPDYE2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPDYE2 Gene

102,550,749 bp from pter
102,562,633 bp from pter
11,885 bases
Plus strand

Genomic View for SPDYE2 Gene

Genes around SPDYE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPDYE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPDYE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPDYE2 Gene

Proteins for SPDYE2 Gene

  • Protein details for SPDYE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Speedy protein E2
    Protein Accession:
    Secondary Accessions:
    • B4DY11

    Protein attributes for SPDYE2 Gene

    402 amino acids
    Molecular mass:
    48300 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPDYE2 Gene


neXtProt entry for SPDYE2 Gene

Post-translational modifications for SPDYE2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPDYE2 Gene

No data available for DME Specific Peptides for SPDYE2 Gene

Domains & Families for SPDYE2 Gene

Gene Families for SPDYE2 Gene

Protein Domains for SPDYE2 Gene


Suggested Antigen Peptide Sequences for SPDYE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Speedy/Ringo family.
  • Belongs to the Speedy/Ringo family.
genes like me logo Genes that share domains with SPDYE2: view

Function for SPDYE2 Gene

Gene Ontology (GO) - Molecular Function for SPDYE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SPDYE2: view

Phenotypes for SPDYE2 Gene

GenomeRNAi human phenotypes for SPDYE2:
genes like me logo Genes that share phenotypes with SPDYE2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPDYE2 Gene

Localization for SPDYE2 Gene

Subcellular locations from

Jensen Localization Image for SPDYE2 Gene COMPARTMENTS Subcellular localization image for SPDYE2 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SPDYE2 Gene

Pathways & Interactions for SPDYE2 Gene

SuperPathways for SPDYE2 Gene

SuperPathway Contained pathways
1 Oocyte meiosis
genes like me logo Genes that share pathways with SPDYE2: view

Pathways by source for SPDYE2 Gene

Interacting Proteins for SPDYE2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000421686 Q495Y8-SPDE2_HUMAN for SPDYE2 Gene via STRING IID UniProtKB

Gene Ontology (GO) - Biological Process for SPDYE2 Gene


No data available for SIGNOR curated interactions for SPDYE2 Gene

Transcripts for SPDYE2 Gene

mRNA/cDNA for SPDYE2 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPDYE2 Gene

Speedy homolog E2 (Xenopus laevis):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPDYE2 Gene

No ASD Table

Relevant External Links for SPDYE2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPDYE2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPDYE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPDYE2 Gene

This gene is overexpressed in Testis (x10.0).

NURSA nuclear receptor signaling pathways regulating expression of SPDYE2 Gene:


SOURCE GeneReport for Unigene cluster for SPDYE2 Gene:

genes like me logo Genes that share expression patterns with SPDYE2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SPDYE2 Gene

Orthologs for SPDYE2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPDYE2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 35
  • 90 (a)
(Canis familiaris)
Mammalia -- 35
  • 66 (a)
-- 35
  • 66 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 52 (a)
(Bos Taurus)
Mammalia -- 35
  • 49 (a)
(Mus musculus)
Mammalia 4933411G11Rik 35
  • 49 (a)
Spdyb 35
  • 48 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 34 (a)
-- 35
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 20 (a)
Species where no ortholog for SPDYE2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPDYE2 Gene

Gene Tree for SPDYE2 (if available)
Gene Tree for SPDYE2 (if available)

Paralogs for SPDYE2 Gene

Paralogs for SPDYE2 Gene

(9) SIMAP similar genes for SPDYE2 Gene using alignment to 1 proteins: Pseudogenes for SPDYE2 Gene

genes like me logo Genes that share paralogs with SPDYE2: view

Variants for SPDYE2 Gene

Sequence variations from dbSNP and Humsavar for SPDYE2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10259412 -- 102,550,215(+) cacca(C/T)gttgg intron-variant, upstream-variant-2KB
rs10266347 -- 102,564,415(+) CTCAC(A/C)CCCTC intron-variant, utr-variant-3-prime
rs1054292 -- 102,563,080(-) AAATA(C/G)CAGTA intron-variant, utr-variant-3-prime
rs112527352 -- 102,552,583(+) GCAGA(C/G)GACGT intron-variant
rs112777636 -- 102,554,560(+) CAAGG(A/G)CTTCA intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SPDYE2 Gene

Variant ID Type Subtype PubMed ID
dgv11541n54 CNV loss 21841781
dgv11542n54 CNV loss 21841781
dgv11543n54 CNV loss 21841781
dgv11544n54 CNV loss 21841781
dgv11545n54 CNV loss 21841781
dgv11548n54 CNV loss 21841781
dgv11550n54 CNV loss 21841781
dgv1944e212 CNV loss 25503493
dgv23n31 CNV gain 19718026
dgv3894e59 CNV duplication 20981092
dgv3899e59 CNV duplication 20981092
dgv3900e59 CNV duplication 20981092
dgv3904e59 CNV duplication 20981092
dgv3906e59 CNV duplication 20981092
dgv6538n100 CNV gain 25217958
dgv6539n100 CNV gain 25217958
dgv6540n100 CNV gain 25217958
dgv6541n100 CNV gain 25217958
esv2734946 CNV deletion 23290073
esv27624 CNV gain+loss 19812545
esv2764015 CNV loss 21179565
esv3327844 CNV duplication 20981092
esv3335589 CNV duplication 20981092
esv3343524 CNV duplication 20981092
esv3377591 CNV duplication 20981092
esv3400561 CNV duplication 20981092
esv3424897 CNV duplication 20981092
esv3891168 CNV gain+loss 25118596
esv3891169 CNV gain+loss 25118596
esv3891171 CNV loss 25118596
esv7079 CNV loss 19470904
nsv1027221 CNV loss 25217958
nsv1034233 CNV loss 25217958
nsv1110493 CNV duplication 24896259
nsv1119231 CNV duplication 24896259
nsv1139905 CNV duplication 24896259
nsv1149718 CNV duplication 26484159
nsv428182 CNV gain 18775914
nsv433392 CNV gain 18776910
nsv436086 CNV insertion 17901297
nsv436552 CNV deletion 17901297
nsv469620 CNV loss 16826518
nsv469682 CNV gain+loss 16826518
nsv471643 CNV gain+loss 15918152
nsv482113 CNV gain 20164927
nsv499135 CNV loss 21111241
nsv499529 CNV loss 21111241
nsv509219 CNV insertion 20534489
nsv5879 CNV deletion 18451855
nsv608005 CNV gain 21841781
nsv608046 CNV loss 21841781
nsv608054 CNV loss 21841781
nsv608055 CNV gain 21841781
nsv8192 CNV gain 18304495
nsv831083 CNV loss 17160897
nsv9 CNV deletion 15895083
nsv967349 CNV duplication 23825009
nsv970562 CNV duplication 23825009
nsv970563 CNV duplication 23825009
nsv970921 CNV duplication 23825009
nsv981562 CNV duplication 23825009
nsv981563 CNV duplication 23825009
nsv981678 CNV duplication 23825009

Variation tolerance for SPDYE2 Gene

Gene Damage Index Score: 0.09; 1.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPDYE2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPDYE2 Gene

Disorders for SPDYE2 Gene

Relevant External Links for SPDYE2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SPDYE2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPDYE2 Gene

Publications for SPDYE2 Gene

  1. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  2. Evolution of the Cdk-activator Speedy/RINGO in vertebrates. (PMID: 22763696) Chauhan S. … Kaldis P. (Cell. Mol. Life Sci. 2012) 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 4 64

Products for SPDYE2 Gene

Sources for SPDYE2 Gene

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