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Aliases for SPDYE2 Gene

Aliases for SPDYE2 Gene

  • Speedy/RINGO Cell Cycle Regulator Family Member E2 2 3 5
  • Speedy Homolog E2 (Xenopus Laevis) 2
  • Putative Speedy Protein E2 3
  • Speedy Homolog E2 3
  • Speedy Protein E2 3
  • Speedy B2-Like 1 3
  • SPDYB2-L1 3

External Ids for SPDYE2 Gene

Previous GeneCards Identifiers for SPDYE2 Gene

  • GC07P101985
  • GC07P102191
  • GC07M096582

Summaries for SPDYE2 Gene

GeneCards Summary for SPDYE2 Gene

SPDYE2 (Speedy/RINGO Cell Cycle Regulator Family Member E2) is a Protein Coding gene. Among its related pathways are Oocyte meiosis. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is SPDYE2B.

Additional gene information for SPDYE2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPDYE2 Gene

Genomics for SPDYE2 Gene

Regulatory Elements for SPDYE2 Gene

Enhancers for SPDYE2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H101855 2 FANTOM5 Ensembl ENCODE dbSUPER 10 -693.2 -693171 4.8 HNRNPUL1 HDGF FOXA2 PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 ZNF2 CUX1 SRRT SPDYE2B SPDYE2 SH2B2 PRKRIP1 GC07P101859 ENSG00000259294
GH07H102748 1.1 ENCODE 17.9 +198.3 198337 1.7 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF207 ZNF143 FOS POLR2J2 RASA4DP SPDYE2 RASA4 DNAJC2 ARMC10 FBXL13 POLR2J FAM185A RPL7AP39
GH07H102008 1 ENCODE dbSUPER 10 -541.5 -541493 1.7 NFIB SIN3A CEBPG E2F1 MTA3 CTBP1 GATA3 HSF1 FOS RCOR1 CUX1 SPDYE2B SPDYE2 RASA4DP GC07M102004 GC07M101947
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPDYE2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SPDYE2 Gene

Genomic Locations for SPDYE2 Gene
chr7:102,550,749-102,562,633
(GRCh38/hg38)
Size:
11,885 bases
Orientation:
Plus strand
chr7:102,191,679-102,202,757
(GRCh37/hg19)

Genomic View for SPDYE2 Gene

Genes around SPDYE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPDYE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPDYE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPDYE2 Gene

Proteins for SPDYE2 Gene

  • Protein details for SPDYE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q495Y8-SPDE2_HUMAN
    Recommended name:
    Speedy protein E2
    Protein Accession:
    Q495Y8
    Secondary Accessions:
    • B4DY11

    Protein attributes for SPDYE2 Gene

    Size:
    402 amino acids
    Molecular mass:
    48300 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPDYE2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPDYE2 Gene

Post-translational modifications for SPDYE2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPDYE2 Gene

No data available for DME Specific Peptides for SPDYE2 Gene

Domains & Families for SPDYE2 Gene

Gene Families for SPDYE2 Gene

Protein Domains for SPDYE2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPDYE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q495Y8

UniProtKB/Swiss-Prot:

SPDE2_HUMAN :
  • Belongs to the Speedy/Ringo family.
Family:
  • Belongs to the Speedy/Ringo family.
genes like me logo Genes that share domains with SPDYE2: view

Function for SPDYE2 Gene

Phenotypes From GWAS Catalog for SPDYE2 Gene

Gene Ontology (GO) - Molecular Function for SPDYE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0019901 protein kinase binding IBA --
genes like me logo Genes that share ontologies with SPDYE2: view

Phenotypes for SPDYE2 Gene

GenomeRNAi human phenotypes for SPDYE2:
genes like me logo Genes that share phenotypes with SPDYE2: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPDYE2 Gene

Localization for SPDYE2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPDYE2 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SPDYE2 Gene

Pathways & Interactions for SPDYE2 Gene

SuperPathways for SPDYE2 Gene

SuperPathway Contained pathways
1 Oocyte meiosis
genes like me logo Genes that share pathways with SPDYE2: view

Pathways by source for SPDYE2 Gene

Interacting Proteins for SPDYE2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000421686%0d%0a9606.ENSP00000321656%0d%0a9606.ENSP00000364721%0d%0a
Selected Interacting proteins: Q495Y8-SPDE2_HUMAN ENSP00000421686 for SPDYE2 Gene via IID UniProtKB STRING

Gene Ontology (GO) - Biological Process for SPDYE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045859 regulation of protein kinase activity IBA --
genes like me logo Genes that share ontologies with SPDYE2: view

No data available for SIGNOR curated interactions for SPDYE2 Gene

Drugs & Compounds for SPDYE2 Gene

No Compound Related Data Available

Transcripts for SPDYE2 Gene

mRNA/cDNA for SPDYE2 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPDYE2 Gene

Speedy homolog E2 (Xenopus laevis):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPDYE2 Gene

No ASD Table

Relevant External Links for SPDYE2 Gene

GeneLoc Exon Structure for
SPDYE2
ECgene alternative splicing isoforms for
SPDYE2

Expression for SPDYE2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPDYE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPDYE2 Gene

This gene is overexpressed in Testis (x10.0).

NURSA nuclear receptor signaling pathways regulating expression of SPDYE2 Gene:

SPDYE2

SOURCE GeneReport for Unigene cluster for SPDYE2 Gene:

Hs.656428

Evidence on tissue expression from TISSUES for SPDYE2 Gene

  • Nervous system(2)
genes like me logo Genes that share expression patterns with SPDYE2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPDYE2 Gene

Orthologs for SPDYE2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPDYE2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 90 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 66 (a)
ManyToMany
-- 34
  • 66 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 52 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 49 (a)
OneToMany
mouse
(Mus musculus)
Mammalia 4933411G11Rik 34
  • 49 (a)
ManyToMany
Spdyb 34
  • 48 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 34 (a)
ManyToMany
-- 34
  • 33 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 20 (a)
OneToMany
Species where no ortholog for SPDYE2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPDYE2 Gene

ENSEMBL:
Gene Tree for SPDYE2 (if available)
TreeFam:
Gene Tree for SPDYE2 (if available)

Paralogs for SPDYE2 Gene

Paralogs for SPDYE2 Gene

(9) SIMAP similar genes for SPDYE2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SPDYE2 Gene

genes like me logo Genes that share paralogs with SPDYE2: view

Variants for SPDYE2 Gene

Sequence variations from dbSNP and Humsavar for SPDYE2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1002471973 -- 102,550,291(+) TTACA(C/G)GCATG intron-variant, upstream-variant-2KB
rs1002503265 -- 102,554,940(+) AAACC(C/T)TGTGT intron-variant
rs1005063621 -- 102,549,933(+) AGTCA(C/T)CCTCC intron-variant, upstream-variant-2KB
rs1011487240 -- 102,550,573(+) CAGCC(C/G/T)GGAGT intron-variant, upstream-variant-2KB
rs1011929442 -- 102,555,405(+) GCCAG(C/G)AGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPDYE2 Gene

Variant ID Type Subtype PubMed ID
nsv981678 CNV duplication 23825009
nsv981563 CNV duplication 23825009
nsv981562 CNV duplication 23825009
nsv970921 CNV duplication 23825009
nsv970563 CNV duplication 23825009
nsv970562 CNV duplication 23825009
nsv967349 CNV duplication 23825009
nsv9 CNV deletion 15895083
nsv831083 CNV loss 17160897
nsv8192 CNV gain 18304495
nsv608055 CNV gain 21841781
nsv608054 CNV loss 21841781
nsv608046 CNV loss 21841781
nsv608005 CNV gain 21841781
nsv5879 CNV deletion 18451855
nsv509219 CNV insertion 20534489
nsv499529 CNV loss 21111241
nsv499135 CNV loss 21111241
nsv482113 CNV gain 20164927
nsv471643 CNV gain+loss 15918152
nsv469682 CNV gain+loss 16826518
nsv469620 CNV loss 16826518
nsv436552 CNV deletion 17901297
nsv436086 CNV insertion 17901297
nsv433392 CNV gain 18776910
nsv428182 CNV gain 18775914
nsv1149718 CNV duplication 26484159
nsv1139905 CNV duplication 24896259
nsv1119231 CNV duplication 24896259
nsv1110493 CNV duplication 24896259
nsv1034233 CNV loss 25217958
nsv1027221 CNV loss 25217958
esv7079 CNV loss 19470904
esv3891171 CNV loss 25118596
esv3891169 CNV gain+loss 25118596
esv3891168 CNV gain+loss 25118596
esv3424897 CNV duplication 20981092
esv3400561 CNV duplication 20981092
esv3377591 CNV duplication 20981092
esv3343524 CNV duplication 20981092
esv3335589 CNV duplication 20981092
esv3327844 CNV duplication 20981092
esv2764015 CNV loss 21179565
esv27624 CNV gain+loss 19812545
esv2734946 CNV deletion 23290073
dgv6541n100 CNV gain 25217958
dgv6540n100 CNV gain 25217958
dgv6539n100 CNV gain 25217958
dgv6538n100 CNV gain 25217958
dgv3906e59 CNV duplication 20981092
dgv3904e59 CNV duplication 20981092
dgv3900e59 CNV duplication 20981092
dgv3899e59 CNV duplication 20981092
dgv3894e59 CNV duplication 20981092
dgv23n31 CNV gain 19718026
dgv1944e212 CNV loss 25503493
dgv11550n54 CNV loss 21841781
dgv11548n54 CNV loss 21841781
dgv11545n54 CNV loss 21841781
dgv11544n54 CNV loss 21841781
dgv11543n54 CNV loss 21841781
dgv11542n54 CNV loss 21841781
dgv11541n54 CNV loss 21841781

Variation tolerance for SPDYE2 Gene

Gene Damage Index Score: 0.09; 1.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPDYE2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPDYE2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPDYE2 Gene

Disorders for SPDYE2 Gene

Relevant External Links for SPDYE2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPDYE2

No disorders were found for SPDYE2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPDYE2 Gene

Publications for SPDYE2 Gene

  1. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  2. Evolution of the Cdk-activator Speedy/RINGO in vertebrates. (PMID: 22763696) Chauhan S … Kaldis P (Cellular and molecular life sciences : CMLS 2012) 3 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 4 60

Products for SPDYE2 Gene

Sources for SPDYE2 Gene

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