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Aliases for SPDYE1 Gene

Aliases for SPDYE1 Gene

  • Speedy/RINGO Cell Cycle Regulator Family Member E1 2 3 5
  • Williams-Beuren Syndrome Chromosomal Region 19 Protein 3 4
  • Speedy E 2 3
  • WBSCR19 3 4
  • Williams Beuren Syndrome Chromosome Region 19 Protein 3
  • Williams Beuren Syndrome Chromosome Region 19 2
  • Speedy Homolog E1 (Xenopus Laevis) 2
  • Speedy Homolog E1 3
  • Speedy Protein E1 3
  • Ringo1 3
  • SPDYE 3

External Ids for SPDYE1 Gene

Previous HGNC Symbols for SPDYE1 Gene

  • WBSCR19

Previous GeneCards Identifiers for SPDYE1 Gene

  • GC07P044009
  • GC07P044040

Summaries for SPDYE1 Gene

Entrez Gene Summary for SPDYE1 Gene

  • This gene is located at chromosome 7p13 which is close to the Williams Beuren syndrome chromosome region 7q11.23. [provided by RefSeq, Jul 2008]

GeneCards Summary for SPDYE1 Gene

SPDYE1 (Speedy/RINGO Cell Cycle Regulator Family Member E1) is a Protein Coding gene. Diseases associated with SPDYE1 include williams-beuren syndrome. Among its related pathways are Oocyte meiosis. An important paralog of this gene is SPDYE2B.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPDYE1 Gene

Genomics for SPDYE1 Gene

Regulatory Elements for SPDYE1 Gene

Genomic Location for SPDYE1 Gene

43,997,440 bp from pter
44,010,124 bp from pter
12,685 bases
Plus strand

Genomic View for SPDYE1 Gene

Genes around SPDYE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPDYE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPDYE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPDYE1 Gene

Proteins for SPDYE1 Gene

  • Protein details for SPDYE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Speedy protein E1
    Protein Accession:
    Secondary Accessions:
    • Q9NTH5

    Protein attributes for SPDYE1 Gene

    336 amino acids
    Molecular mass:
    40668 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPDYE1 Gene

Proteomics data for SPDYE1 Gene at MOPED

Post-translational modifications for SPDYE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPDYE1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPDYE1 Gene

Domains & Families for SPDYE1 Gene

Gene Families for SPDYE1 Gene

Protein Domains for SPDYE1 Gene


Suggested Antigen Peptide Sequences for SPDYE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Speedy/Ringo family.
  • Belongs to the Speedy/Ringo family.
genes like me logo Genes that share domains with SPDYE1: view

Function for SPDYE1 Gene

Phenotypes for SPDYE1 Gene

genes like me logo Genes that share phenotypes with SPDYE1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPDYE1 Gene

Localization for SPDYE1 Gene

Subcellular locations from

Jensen Localization Image for SPDYE1 Gene COMPARTMENTS Subcellular localization image for SPDYE1 gene
Compartment Confidence
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SPDYE1 Gene

Pathways & Interactions for SPDYE1 Gene

SuperPathways for SPDYE1 Gene

genes like me logo Genes that share pathways with SPDYE1: view

Pathways by source for SPDYE1 Gene

Interacting Proteins for SPDYE1 Gene

Gene Ontology (GO) - Biological Process for SPDYE1 Gene


No data available for SIGNOR curated interactions for SPDYE1 Gene

Drugs & Compounds for SPDYE1 Gene

No Compound Related Data Available

Transcripts for SPDYE1 Gene

mRNA/cDNA for SPDYE1 Gene

(9) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPDYE1 Gene

Speedy homolog E1 (Xenopus laevis):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPDYE1 Gene

No ASD Table

Relevant External Links for SPDYE1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPDYE1 Gene

mRNA expression in normal human tissues for SPDYE1 Gene

mRNA differential expression in normal tissues according to GTEx for SPDYE1 Gene

This gene is overexpressed in Testis (x14.7).

SOURCE GeneReport for Unigene cluster for SPDYE1 Gene Hs.645483

genes like me logo Genes that share expression patterns with SPDYE1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SPDYE1 Gene

Orthologs for SPDYE1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPDYE1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC100615808 35
  • 97.82 (n)
  • 95.24 (a)
-- 36
  • 92 (a)
-- 36
  • 92 (a)
(Bos Taurus)
Mammalia -- 36
  • 47 (a)
(Canis familiaris)
Mammalia -- 36
  • 62 (a)
-- 36
  • 62 (a)
(Mus musculus)
Mammalia 4933411G11Rik 36
  • 50 (a)
Spdyb 36
  • 47 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 33 (a)
-- 36
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
Species with no ortholog for SPDYE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPDYE1 Gene

Gene Tree for SPDYE1 (if available)
Gene Tree for SPDYE1 (if available)

Paralogs for SPDYE1 Gene

Paralogs for SPDYE1 Gene

(9) SIMAP similar genes for SPDYE1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPDYE1: view

Variants for SPDYE1 Gene

Structural Variations from Database of Genomic Variants (DGV) for SPDYE1 Gene

Variant ID Type Subtype PubMed ID
nsv428165 CNV Gain 18775914
nsv830980 CNV Loss 17160897
dgv2079e1 CNV Complex 17122850
nsv8082 CNV Gain 18304495
esv27186 CNV Gain 19812545
esv33894 CNV Loss 17666407
nsv887996 CNV Loss 21882294

Variation tolerance for SPDYE1 Gene

Residual Variation Intolerance Score: 91.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.85; 73.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPDYE1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for SPDYE1 Gene

Disorders for SPDYE1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SPDYE1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
williams-beuren syndrome
  • fanconi schlesinger syndrome
- elite association - COSMIC cancer census association via MalaCards


  • Note=SPDYE1 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region (PubMed:12073013). {ECO:0000269 PubMed:12073013}.

Relevant External Links for SPDYE1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SPDYE1: view

No data available for Genatlas for SPDYE1 Gene

Publications for SPDYE1 Gene

  1. Identification of additional transcripts in the Williams-Beuren syndrome critical region. (PMID: 12073013) Merla G. … Reymond A. (Hum. Genet. 2002) 2 3 4 67
  2. Characterization of a new family of cyclin-dependent kinase activators. (PMID: 15574121) Dinarina A. … Nebreda A.R. (Biochem. J. 2005) 3

Products for SPDYE1 Gene

Sources for SPDYE1 Gene

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