SPDYE1 Gene
protein-coding GIFtS: 37
GCID: GC07P044040
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speedy homolog E1 (Xenopus laevis)(Previous name: Williams Beuren syndrome chromosome region 19 )
(Previous symbol: WBSCR19)
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Aliases
for SPDYE1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Speedy Homolog E1 (Xenopus Laevis)1 2 | | Williams Beuren Syndrome Chromosome Region 191 | | WBSCR191 2 3 | | Putative WBSCR19-Like Protein 62 | | Ringo11 2 | | Speedy E2 | | SPDYE1 2 | | Speedy Protein E12 | | Williams-Beuren Syndrome Chromosomal Region 19 Protein2 3 | | Williams Beuren Syndrome Chromosome Region 19 Protein2 |
Export aliases for SPDYE1 gene to outside databasesPrevious GC identifer: GC07P044009 |
Summaries
for SPDYE1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SPDYE1:
This gene is located at chromosome 7p13 which is close to the Williams Beuren syndrome chromosome region 7q11.23.(provided by RefSeq, Jul 2008)
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Genomic Views
for SPDYE1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPDYE1 gene promoter:
RFX1 Tal-1 AML1a SREBP-1c NRSF form 1 NRSF form 2 SREBP-1b Evi-1 AREB6 SREBP-1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPDYE1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPDYE1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p13 Ensembl cytogenetic band: 7p13 HGNC cytogenetic band: 7q11.23SPDYE1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P044040: view genomic region
(about GC identifiers)
Start:
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44,040,488 bp from pter |
End:
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44,049,723 bp from pter |
Size:
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9,236 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 44,079,983-44,089,217 |
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Proteins
for SPDYE1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPDE1_HUMAN, Q8NFV5 (See
protein sequence)Recommended Name: Speedy protein E1 Size: 336 amino acids; 40668 Da
Secondary accessions: Q9NTH5Explore the universe of human proteins at neXtProt for SPDYE1: NX_Q8NFV5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NFV5
SPDYE1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_778234.2
ENSEMBL proteins: ENSP00000258704
Human Recombinant Protein Products:
SPDYE1 Antibody Products:
Assay Products for SPDYE1: |
Protein
Domains /
Families
for SPDYE1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SPDYE1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8NFV5ProtoNet protein and cluster: Q8NFV5 UniProtKB/Swiss-Prot: SPDE1_HUMAN, Q8NFV5Similarity: Belongs to the Speedy/Ringo family |
Function
for SPDYE1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPDYE1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPDYE1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SPDYE1 (NM_175064) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPDYE1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPDYE1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPDYE1 |
|
Pathways & Interactions
for SPDYE1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPDYE1
|
Drugs & Compounds
for SPDYE1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPDYE1
Search CenterWatch for drugs/clinical trials and news about SPDYE1 / SPDE1
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Transcripts
for SPDYE1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPDYE1 gene: NM_175064.2 Unigene Cluster for SPDYE1: Speedy homolog E1 (Xenopus laevis) Hs.645483 [show with all ESTs]Unigene Representative Sequence: AF4120271 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000258704(uc003tjf.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPDYE1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPDYE1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SPDYE1 (NM_175064) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPDYE1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPDYE1 |
Additional cDNA sequence: AF412027.1 AL137266.1 18 DOTS entries: DT.95329841 DT.100017842 DT.121041107 DT.92004896 DT.121122643 DT.121124701 DT.75111632 DT.92419247 DT.121040225 DT.121040300 DT.91902173 DT.95143635 DT.95364332 DT.102840208 DT.121040967 DT.121116310 DT.121116628 DT.95290341 22 AceView cDNA sequences: AL137266 NM_175064 BI041149 AF412027 BI041151 AW851554 BI039248 BF912966 AA584098 AA076958 BX398924 AA077685 AA076853 T11673 BE154255 BI039471 AA076806 BF920212 BG008359 BQ375005 BF897198 AW393752
GeneLoc Exon Structure
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Expression
for SPDYE1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPDYE1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCTGTGTGT
About this image
See SPDYE1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPDYE1
SOURCE GeneReport for Unigene cluster: Hs.645483
SABiosciences Custom PCR Arrays for SPDYE1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPDYE1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SPDYE1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPDYE1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPDYE1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPDYE1 |
Orthologs
for SPDYE1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for SPDYE1 (if available)
TreeFam Gene Tree for SPDYE1 (if available) |
Paralogs
for SPDYE1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SPDYE1 gene
- SPDYA2 SPDYE42 SPDYC2 SPDYE32 SPDYE2L2 SPDYE22
9 SIMAP similar genes for SPDYE1 using alignment to 1 protein entry: SPDE1_HUMAN:SPDYE5 SPDYB2-L1 SPDYE2 SPDYE2L SPDYE6 SPDYE7P
SPDYE3 SPDYE4 SPY1
SPDYE1 for paralogs About GeneDecksing
5/9 Pseudogenes.org Pseudogenes for SPDYE1 (see all 9)
PGOHUM00000237116 PGOHUM00000237117 PGOHUM00000232575 PGOHUM00000232862 PGOHUM00000250887
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Genomic Variants
for SPDYE1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for SPDYE1 (44040488 - 44049723 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for SPDYE1
8 CNVs: 81923 4531 3677 94462 7628 69864 81922 31342 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPDYE1 |
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Disorders
/ Diseases
for SPDYE1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SPDYE1 for disorders About GeneDecksing
UniProtKB/Swiss-Prot: SPDE1_HUMAN, Q8NFV5
Note=SPDYE1 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygousdeletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over betweenhighly homologous low-copy repeat sequences flanking the deleted region
1  disease for SPDYE1: About MalaCardswilliams-beuren syndrome
Export disorders for SPDYE1 gene to outside databases
|
Publications
for SPDYE1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPDYE1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SPDYE1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of additional transcripts in the Williams-Beuren syndrome critical region. (PubMed id 12073013)1, 2, 3 Merla G....Reymond A. (2002)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Characterization of a new family of cyclin-dependent kinase activators. (PubMed id 15574121)1 Dinarina A....Nebreda A.R. (2005)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
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External Searches for SPDYE1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SPDYE1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing SPDYE1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPDYE1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SPDYE1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for SPDYE1 gene:
Search GeneIP for patents involving SPDYE1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPDYE1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPDYE1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPDYE1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPDYE1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPDYE1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPDYE1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SPDYE1 | | OriGene Custom Protein Services for SPDYE1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPDYE1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPDYE1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPDYE1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPDYE1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPDYE1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPDYE1 |
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| | | | Search Tocris compounds for SPDYE1 |
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 | | | SPDYE1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPDYE1 |
|  |  |  | | | | Search ThermoFisher Antibodies for SPDYE1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPDYE1 |
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