SPDYC Gene
protein-coding GIFtS: 40
GCID: GC11P064937
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|
speedy homolog C (Xenopus laevis)
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Aliases
for SPDYC gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Speedy Homolog C (Xenopus Laevis)1 2 | | RINGO C2 3 | | Ringo21 2 | | RINGOC2 | | Rapid Inducer Of G2/M Progression In Oocytes C2 3 | | Speedy C2 | | HSpy/Ringo C2 3 | | Speedy Protein C2 |
Export aliases for SPDYC gene to outside databasesPrevious GC identifers: GC11P064694 GC11P061264 |
Summaries
for SPDYC gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SPDYC_HUMAN, Q5MJ68Function: Promotes progression through the cell cycle via binding and activation of CDK1 and CDK2. Involved in thespindle-assembly checkpoint. Required for recruitment of MAD2L1, BUBR1 and BUB1 to kinetochores. Required for thecorrect localization of the active form of Aurora B in prometaphase
|
Genomic Views
for SPDYC gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPDYC gene promoter:
GATA-3 Tal-1beta CBF-C GATA-2 CBF-A CBF-B CP1C CP1A ITF-2 CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPDYC
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPDYC |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13.1 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13.1SPDYC Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P064937: view genomic region
(about GC identifiers)
Start:
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64,937,625 bp from pter |
End:
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64,940,715 bp from pter |
Size:
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3,091 bases |
Orientation:
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plus strand |
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Proteins
for SPDYC gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPDYC_HUMAN, Q5MJ68 (See
protein sequence)Recommended Name: Speedy protein C Size: 293 amino acids; 33166 Da
Subunit: Interacts with CDK1 and CDK2. Interacts with AURKB
Subcellular location: Cytoplasm. Note=Colocalizes with tubulin gamma during interphase. During mitosis, enriched at thespindle poles and the midbody during telophase
Secondary accessions: B2RP32 B7ZMH7Explore the universe of human proteins at neXtProt for SPDYC: NX_Q5MJ68
SPDYC Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001008778.1
ENSEMBL proteins: ENSP00000366390
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SPDYC for ontologies About GeneDecksing
SPDYC Antibody Products:
Assay Products for SPDYC: |
Protein
Domains /
Families
for SPDYC gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SPDYC for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5MJ68ProtoNet protein and cluster: Q5MJ68 UniProtKB/Swiss-Prot: SPDYC_HUMAN, Q5MJ68Domain: The C-terminus is required for CDK2-activation, but not CDK2-binding (By similarity)Similarity: Belongs to the Speedy/Ringo family |
Function
for SPDYC gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SPDYC_HUMAN, Q5MJ68Function: Promotes progression through the cell cycle via binding and activation of CDK1 and CDK2. Involved in thespindle-assembly checkpoint. Required for recruitment of MAD2L1, BUBR1 and BUB1 to kinetochores. Required for thecorrect localization of the active form of Aurora B in prometaphase
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPDYC
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPDYC
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SPDYC (NM_001008778) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPDYC | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPDYC |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPDYC |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
SPDYC for ontologies About GeneDecksing
|
Pathways & Interactions
for SPDYC gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Oocyte meiosis | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Kegg Pathways (Kegg details for SPDYC):
SPDYC for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPDYC
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for SPDYC (ENSP000003663904) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007049 | cell cycle |
IEA | -- |
SPDYC for ontologies About GeneDecksing
|
Drugs & Compounds
for SPDYC gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPDYC
Search CenterWatch for drugs/clinical trials and news about SPDYC
|
Transcripts
for SPDYC gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPDYC gene: NM_001008778.1 Unigene Cluster for SPDYC: Speedy homolog C (Xenopus laevis) Hs.450642 [show with all ESTs]Unigene Representative Sequence: BC1372461 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000377185(uc010rnz.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPDYC
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPDYC
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SPDYC (NM_001008778) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPDYC | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPDYC |
Additional cDNA sequence: AY820305.1 BC137244.1 BC137246.1 BC144548.1 1 DOTS entry: DT.91749748 4 AceView cDNA sequences: BE279406 BE280100 BE903325 BF132909
GeneLoc Exon Structure
|
Expression
for SPDYC gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPDYC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGGGTTCA
About this image
See SPDYC Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.450642
UniProtKB/Swiss-Prot: SPDYC_HUMAN, Q5MJ68Tissue specificity: Expressed in a variety of tissues including bone marrow, kidney, small intestine, liver, placentaand testis
SABiosciences Custom PCR Arrays for SPDYC
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPDYC
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SPDYC | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPDYC | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPDYC | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPDYC |
Orthologs
for SPDYC gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SPDYC gene from 1/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
AL862447.22 |
-- |
73.53(n) |
|
AL862447.2 |
ENSEMBL Gene Tree for SPDYC (if available)
TreeFam Gene Tree for SPDYC (if available) |
Paralogs
for SPDYC gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SPDYC gene
- SPDYA2 SPDYE42 SPDYE12 SPDYE32 SPDYE2L2 SPDYE22
1 SIMAP similar gene for SPDYC using alignment to 1 protein entry: SPDYC_HUMAN:SPDYA
SPDYC for paralogs About GeneDecksing
|
Genomic Variants
for SPDYC gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SPDYC (64937625 - 64940715 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SPDYC: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPDYC |
|
Disorders
/ Diseases
for SPDYC gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SPDYC for disorders About MalaCards
SPDYC for disorders About GeneDecksing
OMIM gene information: 614030
OMIM disorders: --
Export disorders for SPDYC gene to outside databases
|
Publications
for SPDYC gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPDYC gene integrated from 9 sources:
(articles sorted by number of sources associating them with SPDYC) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins. (PubMed id 15611625)1, 2, 3 Cheng A.... Solomon M.J. (2005)
- RINGO C is required to sustain the spindle-assembly c heckpoint. (PubMed id 20605920)1, 2 MourA^n S....Nebreda A.R. (2010)
- Speedy/Ringo C regulates S and G2 phase progression in human cells. (PubMed id 18802405)1 Cheng A. and Solomon M.J. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for SPDYC gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SPDYC gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SPDYC gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPDYC gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SPDYC | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SPDYC gene:
Search GeneIP for patents involving SPDYC
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPDYC gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPDYC | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPDYC | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPDYC | | | OriGene Protein Over-expression Lysate for SPDYC | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPDYC | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPDYC | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPDYC | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SPDYC | | OriGene Custom Protein Services for SPDYC | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPDYC | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPDYC | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPDYC | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPDYC | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPDYC | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPDYC |
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 |  |  |  | |
| | | | Search Tocris compounds for SPDYC |
| |  |  |  |  | | | | |
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 | | | SPDYC Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPDYC |
|  |  |  | | | | Search ThermoFisher Antibodies for SPDYC |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPDYC |
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