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Aliases for SPDYC Gene

Aliases for SPDYC Gene

  • Speedy/RINGO Cell Cycle Regulator Family Member C 2 3 5
  • Rapid Inducer Of G2/M Progression In Oocytes C 3 4
  • HSpy/Ringo C 3 4
  • RINGO C 3 4
  • Speedy Homolog C (Xenopus Laevis) 2
  • Speedy Homolog C 3
  • Speedy Protein C 3
  • RINGOC 3
  • Ringo2 3

External Ids for SPDYC Gene

Previous GeneCards Identifiers for SPDYC Gene

  • GC11P064694
  • GC11P064937
  • GC11P061264

Summaries for SPDYC Gene

GeneCards Summary for SPDYC Gene

SPDYC (Speedy/RINGO Cell Cycle Regulator Family Member C) is a Protein Coding gene. Among its related pathways are Oocyte meiosis. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is SPDYA.

UniProtKB/Swiss-Prot for SPDYC Gene

  • Promotes progression through the cell cycle via binding and activation of CDK1 and CDK2. Involved in the spindle-assembly checkpoint. Required for recruitment of MAD2L1, BUBR1 and BUB1 to kinetochores. Required for the correct localization of the active form of Aurora B in prometaphase.

Additional gene information for SPDYC Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPDYC Gene

Genomics for SPDYC Gene

GeneHancer (GH) Regulatory Elements for SPDYC Gene

Promoters and enhancers for SPDYC Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I065168 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 578.4 -0.1 -103 2.7 HDGF PKNOX1 SMAD1 ATF1 ARNT ZNF48 TCF12 POLR2B FOS ATF7 SPDYC EIF1AD PCNX3 ZFPL1 SF1 SART1 POLA2 SF3B2 KAT5 PLCB3
GH11I065129 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 33.4 -36.7 -36721 7.2 CLOCK ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC SYVN1 SPDYC LOC728975 SSSCA1 PGAM1P8 CAPN1 ZNHIT2 SF1 POLA2 SCYL1
GH11I065149 Enhancer 1.2 Ensembl ENCODE 22.3 -18.4 -18424 3.4 HDGF PKNOX1 CLOCK ATF1 SIN3A ZNF2 ZNF48 ZNF121 FOS ATF7 SPDYC MRPL49 PGAM1P8 CAPN1 LOC728975 FAU ZNHIT2 POLA2 SF3B2 RNU2-23P
GH11I065288 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11 +125.8 125803 14.5 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 BRCA1 ZNF48 ETS1 ZNF766 FOS POLA2 EHD1 LOC728975 SLC25A45 DPF2 FRMD8 ENSG00000255478 SPDYC CAPN1 PGAM1P8
GH11I065180 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 8.4 +12.8 12786 5.2 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZBTB7B E2F8 ZNF143 ZNF207 LOC728975 CAPN1 SPDYC POLA2 SLC22A20P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPDYC on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPDYC gene promoter:

Genomic Locations for SPDYC Gene

Genomic Locations for SPDYC Gene
chr11:65,169,994-65,173,368
(GRCh38/hg38)
Size:
3,375 bases
Orientation:
Plus strand
chr11:64,937,625-64,940,715
(GRCh37/hg19)

Genomic View for SPDYC Gene

Genes around SPDYC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPDYC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPDYC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPDYC Gene

Proteins for SPDYC Gene

  • Protein details for SPDYC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5MJ68-SPDYC_HUMAN
    Recommended name:
    Speedy protein C
    Protein Accession:
    Q5MJ68
    Secondary Accessions:
    • B2RP32
    • B7ZMH7

    Protein attributes for SPDYC Gene

    Size:
    293 amino acids
    Molecular mass:
    33166 Da
    Quaternary structure:
    • Interacts with CDK1 and CDK2. Interacts with AURKB.

neXtProt entry for SPDYC Gene

Post-translational modifications for SPDYC Gene

No Post-translational modifications

Other Protein References for SPDYC Gene

No data available for DME Specific Peptides for SPDYC Gene

Domains & Families for SPDYC Gene

Gene Families for SPDYC Gene

Protein Domains for SPDYC Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPDYC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5MJ68

UniProtKB/Swiss-Prot:

SPDYC_HUMAN :
  • The C-terminus is required for CDK2-activation, but not CDK2-binding.
  • Belongs to the Speedy/Ringo family.
Domain:
  • The C-terminus is required for CDK2-activation, but not CDK2-binding.
Family:
  • Belongs to the Speedy/Ringo family.
genes like me logo Genes that share domains with SPDYC: view

Function for SPDYC Gene

Molecular function for SPDYC Gene

UniProtKB/Swiss-Prot Function:
Promotes progression through the cell cycle via binding and activation of CDK1 and CDK2. Involved in the spindle-assembly checkpoint. Required for recruitment of MAD2L1, BUBR1 and BUB1 to kinetochores. Required for the correct localization of the active form of Aurora B in prometaphase.

Phenotypes From GWAS Catalog for SPDYC Gene

Gene Ontology (GO) - Molecular Function for SPDYC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IPI 15611625
genes like me logo Genes that share ontologies with SPDYC: view

Phenotypes for SPDYC Gene

GenomeRNAi human phenotypes for SPDYC:
genes like me logo Genes that share phenotypes with SPDYC: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPDYC Gene

Localization for SPDYC Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPDYC Gene

Cytoplasm. Note=Colocalizes with tubulin gamma during interphase. During mitosis, enriched at the spindle poles and the midbody during telophase.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPDYC gene
Compartment Confidence
nucleus 5
extracellular 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SPDYC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SPDYC: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SPDYC Gene

Pathways & Interactions for SPDYC Gene

SuperPathways for SPDYC Gene

SuperPathway Contained pathways
1 Oocyte meiosis
genes like me logo Genes that share pathways with SPDYC: view

Pathways by source for SPDYC Gene

Interacting Proteins for SPDYC Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000366390%0d%0a9606.ENSP00000321656%0d%0a
Selected Interacting proteins: ENSP00000366390 for SPDYC Gene via STRING

Symbol External ID(s) Details
CDC25C

Gene Ontology (GO) - Biological Process for SPDYC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with SPDYC: view

No data available for SIGNOR curated interactions for SPDYC Gene

Drugs & Compounds for SPDYC Gene

No Compound Related Data Available

Transcripts for SPDYC Gene

mRNA/cDNA for SPDYC Gene

(7) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPDYC Gene

Speedy homolog C (Xenopus laevis):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPDYC Gene

No ASD Table

Relevant External Links for SPDYC Gene

GeneLoc Exon Structure for
SPDYC
ECgene alternative splicing isoforms for
SPDYC

Expression for SPDYC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPDYC Gene

mRNA differential expression in normal tissues according to GTEx for SPDYC Gene

This gene is overexpressed in Liver (x20.1), Whole Blood (x11.3), and Testis (x8.9).

NURSA nuclear receptor signaling pathways regulating expression of SPDYC Gene:

SPDYC

SOURCE GeneReport for Unigene cluster for SPDYC Gene:

Hs.450642

mRNA Expression by UniProt/SwissProt for SPDYC Gene:

Q5MJ68-SPDYC_HUMAN
Tissue specificity: Expressed in a variety of tissues including bone marrow, kidney, small intestine, liver, placenta and testis.
genes like me logo Genes that share expression patterns with SPDYC: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPDYC Gene

Orthologs for SPDYC Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPDYC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPDYC 33 34
  • 98.98 (n)
dog
(Canis familiaris)
Mammalia SPDYC 33 34
  • 83.91 (n)
cow
(Bos Taurus)
Mammalia SPDYC 33 34
  • 79.9 (n)
oppossum
(Monodelphis domestica)
Mammalia SPDYC 34
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPDYC 34
  • 52 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm355 34
  • 32 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488624 33
  • 56.82 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
OneToMany
Species where no ortholog for SPDYC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPDYC Gene

ENSEMBL:
Gene Tree for SPDYC (if available)
TreeFam:
Gene Tree for SPDYC (if available)

Paralogs for SPDYC Gene

Paralogs for SPDYC Gene

(1) SIMAP similar genes for SPDYC Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPDYC: view

Variants for SPDYC Gene

Sequence variations from dbSNP and Humsavar for SPDYC Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000401035 -- 65,169,132(+) G/C upstream_transcript_variant
rs1001139298 -- 65,168,321(+) C/T upstream_transcript_variant
rs1002607662 -- 65,171,026(+) A/G 5_prime_UTR_variant, intron_variant
rs1003487679 -- 65,170,681(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1003527877 -- 65,169,880(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SPDYC Gene

Variant ID Type Subtype PubMed ID
nsv509418 CNV insertion 20534489
nsv526181 CNV gain 19592680

Variation tolerance for SPDYC Gene

Residual Variation Intolerance Score: 24.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPDYC Gene

Human Gene Mutation Database (HGMD)
SPDYC
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPDYC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPDYC Gene

Disorders for SPDYC Gene

Additional Disease Information for SPDYC

No disorders were found for SPDYC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPDYC Gene

Publications for SPDYC Gene

  1. Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins. (PMID: 15611625) Cheng A … Solomon MJ (Cell cycle (Georgetown, Tex.) 2005) 2 3 4 58
  2. RINGO C is required to sustain the spindle-assembly checkpoint. (PMID: 20605920) Mourón S … Nebreda AR (Journal of cell science 2010) 3 4 58
  3. Speedy/Ringo C regulates S and G2 phase progression in human cells. (PMID: 18802405) Cheng A … Solomon MJ (Cell cycle (Georgetown, Tex.) 2008) 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for SPDYC Gene

Sources for SPDYC Gene

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