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SPDYC Gene

protein-coding   GIFtS: 41
GCID: GC11P064937

Speedy/RINGO Cell Cycle Regulator Family Member C

(Previous name: speedy homolog C (Xenopus laevis))
  Search for SPDYC
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Speedy/RINGO Cell Cycle Regulator Family Member C1 2     Speedy Homolog C (Xenopus Laevis)1
Rapid Inducer Of G2/M Progression In Oocytes C2 3     Ringo22
HSpy/Ringo C2 3     Speedy C2
RINGO C2 3     Speedy Homolog C2
RINGOC2 5     Speedy Protein C2

External Ids:    HGNC: 326811   Entrez Gene: 3877782   Ensembl: ENSG000002047107   OMIM: 6140305   UniProtKB: Q5MJ683   

Export aliases for SPDYC gene to outside databases

Previous GC identifers: GC11P064694 GC11P061264


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SPDYC Gene:
SPDYC (speedy/RINGO cell cycle regulator family member C) is a protein-coding gene. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is SPDYE2B.

UniProtKB/Swiss-Prot: SPDYC_HUMAN, Q5MJ68
Function: Promotes progression through the cell cycle via binding and activation of CDK1 and CDK2. Involved in the
spindle-assembly checkpoint. Required for recruitment of MAD2L1, BUBR1 and BUB1 to kinetochores. Required for the
correct localization of the active form of Aurora B in prometaphase




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPDYC gene promoter:
         GATA-3   Tal-1beta   CBF-C   GATA-2   CBF-A   CBF-B   CP1C   CP1A   ITF-2   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPDYC promoter sequence
   Search Chromatin IP Primers for SPDYC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPDYC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13.1

SPDYC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPDYC gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P064937:  view genomic region     (about GC identifiers)

Start:
64,937,625 bp from pter      End:
64,940,715 bp from pter
Size:
3,091 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SPDYC_HUMAN, Q5MJ68 (See protein sequence)
Recommended Name: Speedy protein C  
Size: 293 amino acids; 33166 Da
Subunit: Interacts with CDK1 and CDK2. Interacts with AURKB
Secondary accessions: B2RP32 B7ZMH7

Explore the universe of human proteins at neXtProt for SPDYC: NX_Q5MJ68

Explore proteomics data for SPDYC at MOPED


See SPDYC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001008778.1  
ENSEMBL proteins: 
 ENSP00000366390  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
SPDY: Speedy homologs

1 InterPro protein domain:
 IPR020984 Cell_cycle_regulatory_Spy1

Graphical View of Domain Structure for InterPro Entry Q5MJ68

ProtoNet protein and cluster: Q5MJ68

UniProtKB/Swiss-Prot: SPDYC_HUMAN, Q5MJ68
Domain: The C-terminus is required for CDK2-activation, but not CDK2-binding (By similarity)
Similarity: Belongs to the Speedy/Ringo family


SPDYC for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: SPDYC_HUMAN, Q5MJ68
Function: Promotes progression through the cell cycle via binding and activation of CDK1 and CDK2. Involved in the
spindle-assembly checkpoint. Required for recruitment of MAD2L1, BUBR1 and BUB1 to kinetochores. Required for the
correct localization of the active form of Aurora B in prometaphase

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0019901protein kinase binding IPI15611625
     
SPDYC for ontologies           About GeneDecksing


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
SPDYC_HUMAN, Q5MJ68: Cytoplasm. Note=Colocalizes with tubulin gamma during interphase. During mitosis, enriched
at the spindle poles and the midbody during telophase
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus4
cytosol1
extracellular1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus ISS--
GO:0005737cytoplasm IEA--

SPDYC for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for SPDYC About    
See pathways by source

SuperPathContained pathways About
1Oocyte meiosis
Oocyte meiosis0.35
Progesterone-mediated oocyte maturation0.35

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



2 Kegg Pathways  (Kegg details for SPDYC):
    Oocyte meiosis
Progesterone-mediated oocyte maturation


SPDYC for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPDYC
Interactions:

    Search GeneGlobe Interaction Network for SPDYC

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for SPDYC (ENSP000003663904) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
CDC25CENSP000003216564STRING: ENSP00000321656
CDK2ENSP000002669704STRING: ENSP00000266970
About this table

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007049cell cycle IEA--

SPDYC for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for SPDYC



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for SPDYC gene: 
NM_001008778.1  

Unigene Cluster for SPDYC:

Speedy homolog C (Xenopus laevis)
Hs.450642  [show with all ESTs]
Unigene Representative Sequence: BC137246
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000377185(uc010rnz.2)
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Additional mRNA sequence: 

AY820305.1 BC137244.1 BC137246.1 BC144548.1 

1 DOTS entry:

DT.91749748 

4 AceView cDNA sequences:

BE279406 BE280100 BE903325 BF132909 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SPDYC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GTGGGGTTCA
SPDYC Expression
About this image

SPDYC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SPDYC Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.450642

UniProtKB/Swiss-Prot: SPDYC_HUMAN, Q5MJ68
Tissue specificity: Expressed in a variety of tissues including bone marrow, kidney, small intestine, liver,
placenta and testis

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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for SPDYC gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
tropical clawed frog
(Xenopus tropicalis)
Amphibia AL862447.22   -- 73.53(n)    AL862447.2 
        Species with no ortholog for SPDYC

ENSEMBL Gene Tree for SPDYC (if available)
TreeFam Gene Tree for SPDYC (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SPDYC gene
SPDYE2B2  SPDYE42  SPDYA2  SPDYE12  SPDYE32  SPDYE22  
1 SIMAP similar gene for SPDYC using alignment to 1 protein entry:     SPDYC_HUMAN:
SPDYA

SPDYC for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SPDYC (see all 146)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs714686941,2
C,F--64935715(+) CCCAGA/GCCTGA 1 -- us2k12Minor allele frequency- G:0.02NA 122
rs1142457731,2
C,F--64935727(+) AATATG/ATTATC 1 -- us2k11Minor allele frequency- A:0.14WA 118
rs65911771,2
C,F,A,H--64935751(+) AAGACT/ATTGCA 1 -- us2k19Minor allele frequency- A:0.12NS EA NA 932
rs1849657501,2
--64936149(+) AGGCTC/GGGCAT 1 -- us2k10--------
rs1136347071,2
C,F--64936254(+) ATGGCG/AGCACA 1 -- us2k11Minor allele frequency- A:0.50WA 2
rs1886547171,2
--64936281(+) TACTCA/GGGAGG 1 -- us2k10--------
rs79261311,2
C,F,H--64936650(+) AGCGTC/TCAGGA 1 -- us2k16Minor allele frequency- T:0.05NS EA WA 536
rs122926931,2
C,F,H--64936719(+) ACTCTA/CTCTCT 1 -- us2k1 tfbs320Minor allele frequency- C:0.12NS EA NA WA 2466
rs11959581,2
C,F,O,H--64936810(+) GCTGAT/CAAAAT 1 -- us2k131Minor allele frequency- C:0.31EA NA NS WA CSA 2749
rs1511923231,2
C--64936905(+) AGCAGC/TAGGTG 1 -- us2k10--------

HapMap Linkage Disequilibrium report for SPDYC (64937625 - 64940715 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for SPDYC:    About this table    
Variant IDTypeSubtypePubMed ID
nsv509418CNV Insertion20534489
nsv897713CNV Loss21882294
nsv526181CNV Gain19592680

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 614030    OMIM disorders: --


SPDYC for disorders           About GeneDecksing


Export disorders for SPDYC gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SPDYC gene integrated from 10 sources:
(articles sorted by number of sources associating them with SPDYC)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins. (PubMed id 15611625)1, 2, 3 Cheng A.... Solomon M.J. (Cell Cycle 2005)
  2. RINGO C is required to sustain the spindle-assembly checkpoint. (PubMed id 20605920)1, 2 Mouron S....Nebreda A.R. (J. Cell Sci. 2010)
  3. Speedy/Ringo C regulates S and G2 phase progression in human cells. (PubMed id 18802405)1 Cheng A. and Solomon M.J. (Cell Cycle 2008)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 387778 HGNC: 32681 AceView: LOC387778 Ensembl:ENSG00000204710 euGenes: HUgn387778
ECgene: SPDYC Kegg: 387778 H-InvDB: SPDYC

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for SPDYC Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SPDYC gene:
Search GeneIP for patents involving SPDYC

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
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 See all of Abcam's Antibodies, Kits and Proteins for SPDYC
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 Browse ProSpec Recombinant Proteins
 Proteins for SPDYC
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 Browse ESI BIO Cell Lines and PureStem Progenitors for SPDYC
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPDYC
 Browse SwitchGear 3'UTR luciferase reporter plasmids for SPDYC
 SwitchGear Promoter luciferase reporter plasmids for SPDYC
 Search ThermoFisher Antibodies for SPDYC
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPDYC
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPDYC
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SPDYC
 LSBio Antibodies in human, mouse, rat for SPDYC
Customized transgenic rodents for:
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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