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Aliases for SPDYC Gene

Aliases for SPDYC Gene

  • Speedy/RINGO Cell Cycle Regulator Family Member C 2 3 5
  • Rapid Inducer Of G2/M Progression In Oocytes C 3 4
  • HSpy/Ringo C 3 4
  • RINGO C 3 4
  • Speedy Homolog C (Xenopus Laevis) 2
  • Speedy Homolog C 3
  • Speedy Protein C 3
  • Speedy C 3
  • RINGOC 3
  • Ringo2 3

External Ids for SPDYC Gene

Previous GeneCards Identifiers for SPDYC Gene

  • GC11P064694
  • GC11P064937
  • GC11P061264

Summaries for SPDYC Gene

GeneCards Summary for SPDYC Gene

SPDYC (Speedy/RINGO Cell Cycle Regulator Family Member C) is a Protein Coding gene. Among its related pathways are Oocyte meiosis. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is SPDYA.

UniProtKB/Swiss-Prot for SPDYC Gene

  • Promotes progression through the cell cycle via binding and activation of CDK1 and CDK2. Involved in the spindle-assembly checkpoint. Required for recruitment of MAD2L1, BUBR1 and BUB1 to kinetochores. Required for the correct localization of the active form of Aurora B in prometaphase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPDYC Gene

Genomics for SPDYC Gene

Regulatory Elements for SPDYC Gene

Enhancers for SPDYC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F065129 0.8 ENCODE 33.3 -36.7 -36721 7.2 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 SPDYC LOC728975 PGAM1P8 CAPN1 NEAT1 KAT5 SSSCA1-AS1 ENSG00000254501 TM7SF2 VPS51
GH11F065168 0.7 Ensembl ENCODE 28.4 -0.1 -104 2.7 ATF1 PKNOX1 SIN3A ARID4B ZNF48 FOS SP5 GTF2B MXD4 MIER2 SPDYC LOC728975 ZFPL1 EIF1AD PCNX3 TRMT112 FRMD8 PLCB3 KAT5 FAU
GH11F065149 0.8 Ensembl ENCODE 22.3 -18.7 -18664 3.9 HDGF PKNOX1 ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF766 ZNF143 FOS SPDYC MRPL49 PGAM1P8 CAPN1 LOC728975 FAU ZNHIT2 POLA2 SF3B2 RNU2-23P
GH11F065211 1 Ensembl ENCODE 11.1 +43.0 43045 3.1 MAX ZIC2 JUND POLR2A IKZF1 GLIS1 MYC MAFK LOC728975 POLA2 CAPN1 PGAM1P8 CDC42EP2 SPDYC ZFPL1 CDCA5 VPS51 RNU2-23P
GH11F065219 1.2 Ensembl ENCODE 11.1 +50.0 50032 0.8 HDAC1 TFAP4 MAX GABPA OSR2 GATA3 SCRT2 GABPB1 PRDM10 MYC POLA2 LOC728975 CAPN1 PGAM1P8 CDC42EP2 SPDYC ENSG00000255173 ZNHIT2 HIGD1AP10 RNU2-23P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SPDYC on UCSC Golden Path with GeneCards custom track

Genomic Location for SPDYC Gene

Chromosome:
11
Start:
65,169,994 bp from pter
End:
65,173,368 bp from pter
Size:
3,375 bases
Orientation:
Plus strand

Genomic View for SPDYC Gene

Genes around SPDYC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPDYC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPDYC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPDYC Gene

Proteins for SPDYC Gene

  • Protein details for SPDYC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5MJ68-SPDYC_HUMAN
    Recommended name:
    Speedy protein C
    Protein Accession:
    Q5MJ68
    Secondary Accessions:
    • B2RP32
    • B7ZMH7

    Protein attributes for SPDYC Gene

    Size:
    293 amino acids
    Molecular mass:
    33166 Da
    Quaternary structure:
    • Interacts with CDK1 and CDK2. Interacts with AURKB.

neXtProt entry for SPDYC Gene

Post-translational modifications for SPDYC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPDYC Gene

No data available for DME Specific Peptides for SPDYC Gene

Domains & Families for SPDYC Gene

Gene Families for SPDYC Gene

Protein Domains for SPDYC Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPDYC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5MJ68

UniProtKB/Swiss-Prot:

SPDYC_HUMAN :
  • The C-terminus is required for CDK2-activation, but not CDK2-binding.
  • Belongs to the Speedy/Ringo family.
Domain:
  • The C-terminus is required for CDK2-activation, but not CDK2-binding.
Family:
  • Belongs to the Speedy/Ringo family.
genes like me logo Genes that share domains with SPDYC: view

Function for SPDYC Gene

Molecular function for SPDYC Gene

UniProtKB/Swiss-Prot Function:
Promotes progression through the cell cycle via binding and activation of CDK1 and CDK2. Involved in the spindle-assembly checkpoint. Required for recruitment of MAD2L1, BUBR1 and BUB1 to kinetochores. Required for the correct localization of the active form of Aurora B in prometaphase.

Gene Ontology (GO) - Molecular Function for SPDYC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IPI 15611625
genes like me logo Genes that share ontologies with SPDYC: view

Phenotypes for SPDYC Gene

GenomeRNAi human phenotypes for SPDYC:
genes like me logo Genes that share phenotypes with SPDYC: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPDYC Gene

Localization for SPDYC Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPDYC Gene

Cytoplasm. Note=Colocalizes with tubulin gamma during interphase. During mitosis, enriched at the spindle poles and the midbody during telophase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPDYC Gene COMPARTMENTS Subcellular localization image for SPDYC gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for SPDYC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SPDYC: view

Pathways & Interactions for SPDYC Gene

SuperPathways for SPDYC Gene

SuperPathway Contained pathways
1 Oocyte meiosis
genes like me logo Genes that share pathways with SPDYC: view

Pathways by source for SPDYC Gene

Interacting Proteins for SPDYC Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000366390%0d%0a9606.ENSP00000321656%0d%0a
Selected Interacting proteins: ENSP00000366390 for SPDYC Gene via STRING

Symbol External ID(s) Details
CDC25C

Gene Ontology (GO) - Biological Process for SPDYC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with SPDYC: view

No data available for SIGNOR curated interactions for SPDYC Gene

Transcripts for SPDYC Gene

mRNA/cDNA for SPDYC Gene

(7) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPDYC Gene

Speedy homolog C (Xenopus laevis):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPDYC Gene

No ASD Table

Relevant External Links for SPDYC Gene

GeneLoc Exon Structure for
SPDYC
ECgene alternative splicing isoforms for
SPDYC

Expression for SPDYC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPDYC Gene

mRNA differential expression in normal tissues according to GTEx for SPDYC Gene

This gene is overexpressed in Liver (x20.1), Whole Blood (x11.3), and Testis (x8.9).

NURSA nuclear receptor signaling pathways regulating expression of SPDYC Gene:

SPDYC

SOURCE GeneReport for Unigene cluster for SPDYC Gene:

Hs.450642

mRNA Expression by UniProt/SwissProt for SPDYC Gene:

Q5MJ68-SPDYC_HUMAN
Tissue specificity: Expressed in a variety of tissues including bone marrow, kidney, small intestine, liver, placenta and testis.
genes like me logo Genes that share expression patterns with SPDYC: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SPDYC Gene

Orthologs for SPDYC Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPDYC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPDYC 34 35
  • 98.98 (n)
dog
(Canis familiaris)
Mammalia SPDYC 34 35
  • 83.91 (n)
cow
(Bos Taurus)
Mammalia SPDYC 34 35
  • 79.9 (n)
oppossum
(Monodelphis domestica)
Mammalia SPDYC 35
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPDYC 35
  • 52 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm355 35
  • 32 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488624 34
  • 56.82 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
OneToMany
Species where no ortholog for SPDYC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPDYC Gene

ENSEMBL:
Gene Tree for SPDYC (if available)
TreeFam:
Gene Tree for SPDYC (if available)

Paralogs for SPDYC Gene

Paralogs for SPDYC Gene

(1) SIMAP similar genes for SPDYC Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPDYC: view

Variants for SPDYC Gene

Sequence variations from dbSNP and Humsavar for SPDYC Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs111308906 -- 65,172,483(+) GTGAG(A/G)TTTTT reference, missense
rs111611709 -- 65,170,985(+) TTGAC(A/G)ACCGG intron-variant, utr-variant-5-prime
rs113169074 -- 65,173,151(+) GGTTT(C/G)TTCTC intron-variant, reference, missense
rs113634707 -- 65,168,783(+) ATGGC(A/G)GCACA upstream-variant-2KB
rs114245773 -- 65,168,256(+) AATAT(A/G)TTATC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SPDYC Gene

Variant ID Type Subtype PubMed ID
nsv509418 CNV insertion 20534489
nsv526181 CNV gain 19592680

Variation tolerance for SPDYC Gene

Residual Variation Intolerance Score: 24.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPDYC Gene

Human Gene Mutation Database (HGMD)
SPDYC
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPDYC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPDYC Gene

Disorders for SPDYC Gene

Relevant External Links for SPDYC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPDYC

No disorders were found for SPDYC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPDYC Gene

Publications for SPDYC Gene

  1. Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins. (PMID: 15611625) Cheng A. … Solomon M.J. (Cell Cycle 2005) 2 3 4 64
  2. RINGO C is required to sustain the spindle-assembly checkpoint. (PMID: 20605920) Mouron S. … Nebreda A.R. (J. Cell Sci. 2010) 3 4 64
  3. Speedy/Ringo C regulates S and G2 phase progression in human cells. (PMID: 18802405) Cheng A. … Solomon M.J. (Cell Cycle 2008) 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for SPDYC Gene

Sources for SPDYC Gene

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