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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPDYC Gene

protein-coding   GIFtS: 40
GCID: GC11P064937

Speedy/RINGO Cell Cycle Regulator Family Member C

(Previous name: speedy homolog C (Xenopus laevis))
  Search for SPDYC
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Speedy/RINGO Cell Cycle Regulator Family Member C1 2     RINGOC2
Rapid Inducer Of G2/M Progression In Oocytes C2 3     Ringo22
HSpy/Ringo C2 3     Speedy C2
RINGO C2 3     Speedy Homolog C2
Speedy Homolog C (Xenopus Laevis)1     Speedy Protein C2

External Ids:    HGNC: 326811   Entrez Gene: 3877782   Ensembl: ENSG000002047107   OMIM: 6140305   UniProtKB: Q5MJ683   

Export aliases for SPDYC gene to outside databases

Previous GC identifers: GC11P064694 GC11P061264


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SPDYC Gene: 
SPDYC (speedy/RINGO cell cycle regulator family member C) is a protein-coding gene. Among its related super-pathways are Progesterone-mediated oocyte maturation. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is SPDYE2B.

UniProtKB/Swiss-Prot: SPDYC_HUMAN, Q5MJ68
Function: Promotes progression through the cell cycle via binding and activation of CDK1 and CDK2. Involved in the
spindle-assembly checkpoint. Required for recruitment of MAD2L1, BUBR1 and BUB1 to kinetochores. Required for the
correct localization of the active form of Aurora B in prometaphase




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPDYC gene promoter:
         GATA-3   Tal-1beta   CBF-C   GATA-2   CBF-A   CBF-B   CP1C   CP1A   ITF-2   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPDYC promoter sequence
   Search SABiosciences Chromatin IP Primers for SPDYC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPDYC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13.1

SPDYC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPDYC gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P064937:  view genomic region     (about GC identifiers)

Start:
64,937,625 bp from pter      End:
64,940,715 bp from pter
Size:
3,091 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SPDYC_HUMAN, Q5MJ68 (See protein sequence)
Recommended Name: Speedy protein C  
Size: 293 amino acids; 33166 Da
Subunit: Interacts with CDK1 and CDK2. Interacts with AURKB
Subcellular location: Cytoplasm. Note=Colocalizes with tubulin gamma during interphase. During mitosis, enriched
at the spindle poles and the midbody during telophase
Secondary accessions: B2RP32 B7ZMH7

Explore the universe of human proteins at neXtProt for SPDYC: NX_Q5MJ68

Explore proteomics data for SPDYC at MOPED 

SPDYC Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

SPDYC Protein Expression

REFSEQ proteins: NP_001008778.1  
ENSEMBL proteins: 
 ENSP00000366390  

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus ISS--
GO:0005737cytoplasm IEA--

SPDYC for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
SPDY: Speedy homologs

1 InterPro protein domain:
 IPR020984 Cell_cycle_regulatory_Spy1

Graphical View of Domain Structure for InterPro Entry Q5MJ68

ProtoNet protein and cluster: Q5MJ68

UniProtKB/Swiss-Prot: SPDYC_HUMAN, Q5MJ68
Domain: The C-terminus is required for CDK2-activation, but not CDK2-binding (By similarity)
Similarity: Belongs to the Speedy/Ringo family


SPDYC for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: SPDYC_HUMAN, Q5MJ68
Function: Promotes progression through the cell cycle via binding and activation of CDK1 and CDK2. Involved in the
spindle-assembly checkpoint. Required for recruitment of MAD2L1, BUBR1 and BUB1 to kinetochores. Required for the
correct localization of the active form of Aurora B in prometaphase

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0019901protein kinase binding IPI15611625
     
SPDYC for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for SPDYC About                                                                                                See pathways by source

SuperPathContained pathways About
1Oocyte meiosis
Progesterone-mediated oocyte maturation0.35
Oocyte meiosis0.35

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



2         Kegg Pathways  (Kegg details for SPDYC):
    Oocyte meiosis
Progesterone-mediated oocyte maturation


SPDYC for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPDYC

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for SPDYC (ENSP000003663904) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
CDC25CENSP000003216564STRING: ENSP00000321656
CDK2ENSP000002669704STRING: ENSP00000266970
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007049cell cycle IEA--

SPDYC for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for SPDYC

Search CenterWatch for drugs/clinical trials and news about SPDYC

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SPDYC gene: 
NM_001008778.1  

Unigene Cluster for SPDYC:

Speedy homolog C (Xenopus laevis)
Hs.450642  [show with all ESTs]
Unigene Representative Sequence: BC137246
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000377185(uc010rnz.2)
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Additional mRNA sequence: 

AY820305.1 BC137244.1 BC137246.1 BC144548.1 

1 DOTS entry:

DT.91749748 

4 AceView cDNA sequences:

BE280100 BE279406 BE903325 BF132909 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SPDYC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GTGGGGTTCA
SPDYC Expression
About this image


See SPDYC Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.450642

UniProtKB/Swiss-Prot: SPDYC_HUMAN, Q5MJ68
Tissue specificity: Expressed in a variety of tissues including bone marrow, kidney, small intestine, liver,
placenta and testis

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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for SPDYC gene from 2/7 species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia SPDYC1 speedy homolog C (Xenopus laevis) 79.6(n)
72.76(a)
  476026  XM_533235.3  XP_533235.3 
tropical clawed frog
(Xenopus tropicalis)
Amphibia AL862447.22   -- 73.53(n)    AL862447.2 


ENSEMBL Gene Tree for SPDYC (if available)
TreeFam Gene Tree for SPDYC (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for SPDYC gene
SPDYE2B2  SPDYE42  SPDYA2  SPDYE12  SPDYE32  SPDYE22  
1 SIMAP similar gene for SPDYC using alignment to 1 protein entry:     SPDYC_HUMAN:
SPDYA

SPDYC for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/146 SNPs in SPDYC are shown (see all 146)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs714686941,2
C,F--64935715(+) CCCAGA/GCCTGA 1 -- us2k12Minor allele frequency- G:0.02NA 122
rs1142457731,2
C,F--64935727(+) AATATG/ATTATC 1 -- us2k11Minor allele frequency- A:0.14WA 118
rs65911771,2
C,F,A,H--64935751(+) AAGACT/ATTGCA 1 -- us2k19Minor allele frequency- A:0.12NS EA NA 932
rs1849657501,2
--64936149(+) AGGCTC/GGGCAT 1 -- us2k10--------
rs1136347071,2
C,F--64936254(+) ATGGCG/AGCACA 1 -- us2k11Minor allele frequency- A:0.50WA 2
rs1886547171,2
--64936281(+) TACTCA/GGGAGG 1 -- us2k10--------
rs79261311,2
C,F,H--64936650(+) AGCGTC/TCAGGA 1 -- us2k16Minor allele frequency- T:0.05NS EA WA 536
rs122926931,2
C,F,H--64936719(+) ACTCTA/CTCTCT 1 -- us2k1 tfbs320Minor allele frequency- C:0.12NS EA NA WA 2466
rs11959581,2
C,F,O,H--64936810(+) GCTGAT/CAAAAT 1 -- us2k131Minor allele frequency- C:0.31EA NA NS WA CSA 2749
rs1511923231,2
C--64936905(+) AGCAGC/TAGGTG 1 -- us2k10--------

HapMap Linkage Disequilibrium report for SPDYC (64937625 - 64940715 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for SPDYC:    About this table     
Variant IDTypeSubtypePubMed ID
nsv509418CNV Insertion20534489
nsv897713CNV Loss21882294
nsv526181CNV Gain19592680

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SPDYC for disorders           About MalaCards
OMIM gene information: 614030    OMIM disorders: --


SPDYC for disorders           About GeneDecksing


Export disorders for SPDYC gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for SPDYC gene integrated from 9 sources:
(articles sorted by number of sources associating them with SPDYC)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins. (PubMed id 15611625)1, 2, 3 Cheng A.... Solomon M.J. (2005)
  2. RINGO C is required to sustain the spindle-assembly c heckpoint. (PubMed id 20605920)1, 2 MourA^n S....Nebreda A.R. (2010)
  3. Speedy/Ringo C regulates S and G2 phase progression in human cells. (PubMed id 18802405)1 Cheng A. and Solomon M.J. (2008)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 387778 HGNC: 32681 AceView: LOC387778 Ensembl:ENSG00000204710 euGenes: HUgn387778
ECgene: SPDYC Kegg: 387778 H-InvDB: SPDYC

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for SPDYC Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for SPDYC gene:
Search GeneIP for patents involving SPDYC

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 Regulatory tfbs in SPDYC promoter
 Search Chromatin IP Primers for SPDYC
 RT2 qPCR Primer Assay in human, mouse / rat SPDYC
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 Search Tocris compounds for SPDYC
 Browse Sino Biological Proteins and Antibodies
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
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 Proteins for SPDYC
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 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPDYC
 inGenious Targeting Laboratory - Custom generated mouse model solutions for SPDYC
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Customized transgenic rodents for:
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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