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SPDYA Gene

protein-coding   GIFtS: 52
GCID: GC02P029007

Speedy/RINGO Cell Cycle Regulator Family Member A

(Previous names: speedy homolog 1 (Drosophila), speedy homolog A (Xenopus...)
(Previous symbol: SPDY1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Speedy/RINGO Cell Cycle Regulator Family Member A1 2     Speedy Homolog A (Xenopus Laevis)1
SPDY11 2 3     RINGO32
SPY12 3 5     Speedy Homolog A2
Rapid Inducer Of G2/M Progression In Oocytes A2 3     Speedy Protein A2
HSpy/Ringo A2 3     speedy-12
RINGO A2 3     Speedy-13
RINGOA2 5     Spy13
Speedy Homolog 1 (Drosophila)1     

External Ids:    HGNC: 306131   Entrez Gene: 2457112   Ensembl: ENSG000001638067   OMIM: 6140295   UniProtKB: Q5MJ703   

Export aliases for SPDYA gene to outside databases

Previous GC identifers: GC02P028828 GC02P028858


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SPDYA Gene:
SPDYA (speedy/RINGO cell cycle regulator family member A) is a protein-coding gene. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is SPDYE2B.

UniProtKB/Swiss-Prot: SPDYA_HUMAN, Q5MJ70
Function: Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1, CDK2 and
CDKN1B/KIP1. Can activate CDK2 without promoting CDK2 phosphorylation. Mediates cell survival during the DNA
damage process through activation of CDK2

Gene Wiki entry for SPDYA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPDYA gene promoter:
         E2F-3a   E2F-4   E2F-5   SREBP-1a   E2F-1   E2F   HNF-1   E2F-2   HNF-1A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPDYA promoter sequence
   Search Chromatin IP Primers for SPDYA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPDYA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.2   Ensembl cytogenetic band:  2p23.2   HGNC cytogenetic band: 2p23

SPDYA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPDYA gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P029007:  view genomic region     (about GC identifiers)

Start:
29,005,383 bp from pter      End:
29,073,477 bp from pter
Size:
68,095 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SPDYA_HUMAN, Q5MJ70 (See protein sequence)
Recommended Name: Speedy protein A  
Size: 313 amino acids; 36463 Da
Subunit: Interacts with CDK1, CDK2 and CDKN1B/KIP1. Found in a complex with both CDK2 and CDKN1B/KIP1
Secondary accessions: Q53R05 Q5MJ69
Alternative splicing: 2 isoforms:  Q5MJ70-2   Q5MJ70-1   

Explore the universe of human proteins at neXtProt for SPDYA: NX_Q5MJ70

Explore proteomics data for SPDYA at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SPDYA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001008779.1  NP_001136106.1  NP_877433.2  

    ENSEMBL proteins: 
     ENSP00000368898   ENSP00000335628   ENSP00000414086   ENSP00000395240  

    SPDYA Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SPDYA

     
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    antibodies-online proteins for SPDYA (4 products) 

     
    antibodies-online peptides for SPDYA

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SPDY: Speedy homologs

    1 InterPro protein domain:
     IPR020984 Cell_cycle_regulatory_Spy1

    Graphical View of Domain Structure for InterPro Entry Q5MJ70

    ProtoNet protein and cluster: Q5MJ70

    UniProtKB/Swiss-Prot: SPDYA_HUMAN, Q5MJ70
    Domain: The C-terminus is required for CDK2-activation, but not CDK2-binding (By similarity)
    Similarity: Belongs to the Speedy/Ringo family


    Find genes that share domains with SPDYA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPDYA_HUMAN, Q5MJ70
    Function: Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1, CDK2 and
    CDKN1B/KIP1. Can activate CDK2 without promoting CDK2 phosphorylation. Mediates cell survival during the DNA
    damage process through activation of CDK2

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019901protein kinase binding IPI11980914
         
    Find genes that share ontologies with SPDYA           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SPDYA:
     Cell division defect  Increased G1 DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SPDYA

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    miRTarBase miRNAs that target SPDYA:
    hsa-mir-335-5p (MIRT018986)

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    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): SPDYA 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPDYA_HUMAN, Q5MJ70: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion2
    extracellular1
    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11980914

    Find genes that share ontologies with SPDYA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SPDYA About    
    See pathways by source

    SuperPathContained pathways About
    1Oocyte meiosis
    Oocyte meiosis0.35
    Progesterone-mediated oocyte maturation0.35


    Find genes that share SuperPaths with SPDYA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Kegg Pathways  (Kegg details for SPDYA):
        Oocyte meiosis
    Progesterone-mediated oocyte maturation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPDYA
    Interactions:

        GeneGlobe Interaction Network for SPDYA

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for SPDYA (Q5MJ702, 3 ENSP000003356284) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKP2Q133092, 3, ENSP000002742554MINT-7226431 MINT-7226448 I2D: score=1 STRING: ENSP00000274255
    UBCP0CG482, 3, ENSP000003448184MINT-7226413 I2D: score=1 STRING: ENSP00000344818
    CDK2P249413, ENSP000002669704I2D: score=2 STRING: ENSP00000266970
    CDKN1BP465273, ENSP000002288724I2D: score=2 STRING: ENSP00000228872
    CRKP461083I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle IDA11980914
    GO:0006974cellular response to DNA damage stimulus IDA12839962
    GO:0007140male meiosis ISS--
    GO:0007275multicellular organismal development IEA--
    GO:0008284positive regulation of cell proliferation IDA11980914

    Find genes that share ontologies with SPDYA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPDYA



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SPDYA gene (3 alternative transcripts): 
    NM_001008779.1  NM_001142634.1  NM_182756.3  

    Unigene Cluster for SPDYA:

    Speedy homolog A (Xenopus laevis)
    Hs.511956  [show with all ESTs]
    Unigene Representative Sequence: NM_182756
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000462832(uc002rmi.3 uc002rml.3) ENST00000379579(uc002rmk.3)
    ENST00000491044 ENST00000334056(uc002rmj.3) ENST00000449210 ENST00000439646
    ENST00000467226
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat SPDYA

    Additional mRNA sequence: 

    AY820303.1 AY820304.1 BC047224.1 BC093005.1 

    15 DOTS entries:

    DT.120950860  DT.100745480  DT.40111965  DT.95234781  DT.121643516  DT.40261214  DT.100702139  DT.95268879 
    DT.100806312  DT.40312749  DT.95268878  DT.97823319  DT.100712294  DT.100788641  DT.313043 

    Selected AceView cDNA sequences (see all 727):

    BM932305 AI093310 AI470737 BU678895 BE047297 CR593644 AA292890 AI627415 
    AA760857 F06377 BE670191 AA280351 CD722576 CR601128 AA281847 AI432419 
    AU137304 BQ946172 AA825575 X80910 BQ436946 BG616739 AI678473 BM701727 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SPDYA (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^
    SP1:                                      -                       -           -     -     -                       -                 -     -                     
    SP2:                                -     -                       -           -     -     -                       -                 -     -                     
    SP3:                                -     -     -     -     -     -           -     -     -                       -                 -     -                     
    SP4:                    -     -     -     -                       -           -     -     -                                                                     
    SP5:                                -     -     -     -     -     -           -           -                                                                     

    ExUns: 13a · 13b ^ 14a · 14b · 14c
    SP1:  -                           
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for SPDYA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SPDYA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTTTAGGG
    SPDYA Expression
    About this image


    SPDYA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             XX Germ Cells Ovigerous Cord
             Ovigerous Cord
     
     Intermediate Mesoderm (Gastrulation Derivatives)
             Mesonephros
     
     Gonad
             XX Germ Cells Ovigerous Cord
     
     Testis (Reproductive System)
    SPDYA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPDYA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.511956

    UniProtKB/Swiss-Prot: SPDYA_HUMAN, Q5MJ70
    Tissue specificity: Highly expressed in testis. Expressed at a low level in wide range of tissues including bone
    marrow, brain, heart, kidney, colon, liver, placenta, spleen, skeletal muscle, salivary gland, thyroid gland,
    thymus, trachea and uterus. Expressed at a slightly higher level in adrenal gland, cerebellum, small intestine,
    lung, prostate and trachea. Expression is cell cycle-dependent, being restricted to cells in G1/S phase

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SPDYA gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spdya1 , 5 speedy homolog A (Xenopus laevis)1, 5 88.06(n)1
    84.19(a)1
      17 (41.87 cM)5
    708911  NM_029254.11  NP_083530.11 
     715520615 
    chicken
    (Gallus gallus)
    Aves SPDYA1 speedy/RINGO cell cycle regulator family member A 70.71(n)
    64.59(a)
      101748777  XM_004940195.1  XP_004940252.1 
    lizard
    (Anolis carolinensis)
    Reptilia SPDYA6
    speedy/RINGO cell cycle regulator family member A
    76(a)
    1 ↔ 1
    1(248297006-248301696)
    African clawed frog
    (Xenopus laevis)
    Amphibia ls272 p33 ringo 75.53(n)    AJ133500.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.158952 Transcribed sequence with weak similarity to protein more 75.21(n)    BI979855.1 


    ENSEMBL Gene Tree for SPDYA (if available)
    TreeFam Gene Tree for SPDYA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SPDYA gene
    SPDYE2B2  SPDYE42  SPDYC2  SPDYE12  SPDYE32  SPDYE22  
    2 SIMAP similar genes for SPDYA using alignment to 3 protein entries:     SPDYA_HUMAN (see all proteins):
    SPY1    SPDYC

    Find genes that share paralogs with SPDYA           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SPDYA (see all 745)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1868689571,2
    --29031704(+) AAATTC/TGCCCC 2 -- us2k10--------
    rs1929000501,2
    --29031732(+) AGGTGG/TTATCA 2 -- us2k10--------
    rs1149640991,2
    C,F--29031872(+) CACACC/AAACAT 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1398140971,2
    --29031913(+) AGAACA/GCTCAA 2 -- us2k10--------
    rs1431567001,2
    --29032012(+) ATTTGC/GTGGCT 2 -- us2k10--------
    rs777006811,2
    C,F--29032136(+) CTCACT/CGTGCC 2 -- us2k11Minor allele frequency- C:0.02WA 118
    rs76014131,2
    C,F,A,H--29032238(+) TCTGTG/ATTTTT 2 -- us2k128Minor allele frequency- A:0.29NA NS EA WA 2906
    rs780720751,2
    C,F--29032251(+) TGTAGC/G/TGGACA 2 -- us2k11WA 118
    rs1844506831,2
    --29032301(+) TTAATA/CATCAC 2 -- us2k10--------
    rs803195991,2
    C,F--29032314(+) CACCGG/TTACCT 2 -- us2k11Minor allele frequency- T:0.16WA 118

    HapMap Linkage Disequilibrium report for SPDYA (29005383 - 29073477 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SPDYA:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv819532CNV Loss19587683

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SPDYA
    DNA2.0 Custom Variant and Variant Library Synthesis for SPDYA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614029    OMIM disorders: --


    Find genes that share disorders with SPDYA           About GenesLikeMe


    Export disorders for SPDYA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SPDYA gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with SPDYA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins. (PubMed id 15611625)1, 2, 3 Cheng A.... Solomon M.J. (Cell Cycle 2005)
    2. Human Spy1 promotes survival of mammalian cells following DNA damage. (PubMed id 12839962)1, 2, 3 Barnes E.A....Donoghue D.J. (Cancer Res. 2003)
    3. Human Speedy: a novel cell cycle regulator that enhances proliferation through activation of Cdk2. (PubMed id 11980914)1, 2, 3 Porter L.A.... Donoghue D.J. (J. Cell Biol. 2002)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Spy1 interacts with p27Kip1 to allow G1/S progression. (PubMed id 12972555)1, 2 Porter L.A.... Donoghue D.J. (Mol. Biol. Cell 2003)
    7. The cyclin-like protein Spy1 regulates growth and division characteristics of the CD133+ population in human glioma. (PubMed id 24434210)1 Lubanska D....Porter L.A. (Cancer Cell 2014)
    8. Expression of Spy1 protein in human non-Hodgkin's lymphomas is correlated with phosphorylation of p27 Kip1 on Thr187 and cell proliferation. (PubMed id 22492278)1 Hang Q....He S. (Med. Oncol. 2012)
    9. Spy1 is frequently overexpressed in malignant gliomas and critically regulates the proliferation of glioma cells. (PubMed id 22447439)1 Zhang L....Cheng C. (J. Mol. Neurosci. 2012)
    10. Expression and prognostic role of Spy1 as a novel cell cycle protein in hepatocellular carcinoma. (PubMed id 19686732)1 Ke Q....Shen A. (Exp. Mol. Pathol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 245711 HGNC: 30613 AceView: PPP1CBandSPDY1 Ensembl:ENSG00000163806 euGenes: HUgn245711
    ECgene: SPDYA Kegg: 245711 H-InvDB: SPDYA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SPDYA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SPDYA gene:
    Search GeneIP for patents involving SPDYA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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