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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPDYA Gene

protein-coding   GIFtS: 53
GCID: GC02P029007

speedy homolog A (Xenopus laevis)

(Previous name: speedy homolog 1 (Drosophila) )
(Previous symbol: SPDY1)
 Explore 4 diseases affiliated with
SPDYA via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SPDYA    

Aliases
for SPDYA gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Speedy Homolog A (Xenopus Laevis)1 2     Speedy Homolog 1 (Drosophila)1
SPDY11 2 3     RINGO32
SPY11 2 3     RINGOA2
Rapid Inducer Of G2/M Progression In Oocytes A2 3     Speedy Protein A2
HSpy/Ringo A2 3     Speedy-13
RINGO A2 3     Speedy-13
Ringo31     Spy13

External Ids:    HGNC: 306131   Entrez Gene: 2457112   Ensembl: ENSG000001638067   OMIM: 6140295   UniProtKB: Q5MJ703   

Export aliases for SPDYA gene to outside databases

Previous GC identifers: GC02P028828 GC02P028858


Summaries
for SPDYA gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: SPDYA_HUMAN, Q5MJ70
Function: Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1, CDK2 and CDKN1B/KIP1.
Can activate CDK2 without promoting CDK2 phosphorylation. Mediates cell survival during the DNA damage process through
activation of CDK2

Gene Wiki entry for SPDYA


Genomic Views
for SPDYA gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPDYA gene promoter:
         E2F-3a   E2F-4   E2F-5   SREBP-1a   E2F-1   E2F   HNF-1   E2F-2   HNF-1A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SPDYA promoter sequence
   Search SABiosciences Chromatin IP Primers for SPDYA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPDYA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.2   Ensembl cytogenetic band:  2p23.2   HGNC cytogenetic band: 2p23

SPDYA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPDYA gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P029007:  view genomic region     (about GC identifiers)

Start:
 29,005,383 bp from pter      End:
 29,073,477 bp from pter
Size:
 68,095 bases      Orientation:
 plus strand

Proteins
for SPDYA gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SPDYA_HUMAN, Q5MJ70 (See protein sequence)
Recommended Name: Speedy protein A  
Size: 313 amino acids; 36463 Da
Subunit: Interacts with CDK1, CDK2 and CDKN1B/KIP1. Found in a complex with both CDK2 and CDKN1B/KIP1
Subcellular location: Nucleus
Secondary accessions: Q53R05 Q5MJ69
Alternative splicing: 2 isoforms:  Q5MJ70-2   Q5MJ70-1   

Explore the universe of human proteins at neXtProt for SPDYA: NX_Q5MJ70

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5MJ70

    • SPDYA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001008779.1  NP_001136106.1  NP_877433.2  

    ENSEMBL proteins: 
     ENSP00000368898   ENSP00000335628   ENSP00000414086   ENSP00000395240  

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    Novus Biologicals SPDYA Proteins
    Novus Biologicals SPDYA Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SPDYA

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11980914


    SPDYA for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for SPDYA gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SPDYA for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR020984 Cell_cycle_regulatory_Spy1

    Graphical View of Domain Structure for InterPro Entry Q5MJ70

    ProtoNet protein and cluster: Q5MJ70

    UniProtKB/Swiss-Prot: SPDYA_HUMAN, Q5MJ70
    Domain: The C-terminus is required for CDK2-activation, but not CDK2-binding (By similarity)
    Similarity: Belongs to the Speedy/Ringo family


    Function
    for SPDYA gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SPDYA_HUMAN, Q5MJ70
    Function: Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1, CDK2 and CDKN1B/KIP1.
    Can activate CDK2 without promoting CDK2 phosphorylation. Mediates cell survival during the DNA damage process through
    activation of CDK2

    miRNA
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    Inhib. RNA
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    OriGene shRNA RFP: SPDYA
    OriGene siRNA: SPDYA
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    Gene Editing
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    Clone
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    In Situ Assay
    Products:       
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019901protein kinase binding IPI12839962


    SPDYA for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for SPDYA:
     Cell division defect  Increased G1 DNA content 


    Pathways & Interactions
    for SPDYA gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Oocyte meiosis
    		Oocyte meiosis1.00
    		Progesterone-mediated oocyte maturation0.35

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    2         Kegg Pathways  (Kegg details for SPDYA):
        Oocyte meiosis
    Progesterone-mediated oocyte maturation


    SPDYA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SPDYA

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/7 Interacting proteins for SPDYA (Q5MJ702, 3 ENSP000003356284) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKP2Q133092, 3, ENSP000002742554MINT-7226431 MINT-7226448 I2D: score=1 STRING: ENSP00000274255
    UBCP0CG482, 3, ENSP000003448184MINT-7226413 I2D: score=1 STRING: ENSP00000344818
    CDK2P249413, ENSP000002669704I2D: score=2 STRING: ENSP00000266970
    CDKN1BP465273, ENSP000002288724I2D: score=2 STRING: ENSP00000228872
    CRKP461083I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle IDA11980914
    GO:0006974response to DNA damage stimulus IDA12839962
    GO:0007140male meiosis ISS--
    GO:0007275multicellular organismal development IEA--
    GO:0008284positive regulation of cell proliferation IDA11980914


    SPDYA for ontologies           About GeneDecksing



    Drugs & Compounds
    for SPDYA gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPDYA
    Search CenterWatch for drugs/clinical trials and news about SPDYA 

    Transcripts
    for SPDYA gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SPDYA gene (3 alternative transcripts): 
    NM_001008779.1  NM_001142634.1  NM_182756.3  

    Unigene Cluster for SPDYA:

    Speedy homolog A (Xenopus laevis)
    Hs.511956  [show with all ESTs]
    Unigene Representative Sequence: NM_182756
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000462832(uc002rmi.3 uc002rml.3) ENST00000379579(uc002rmk.3)
    ENST00000491044 ENST00000334056(uc002rmj.3) ENST00000449210 ENST00000439646
    ENST00000467226

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
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    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): SPDYA 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPDYA (see all 7)
    OriGene shRNA RFP: SPDYA
    OriGene siRNA: SPDYA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPDYA
    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPDYA

    Additional cDNA sequence: 

    AY820303.1 AY820304.1 BC047224.1 BC093005.1 

    15 DOTS entries:

    DT.120950860  DT.100745480  DT.40111965  DT.95234781  DT.121643516  DT.40261214  DT.100702139  DT.95268879 
    DT.100806312  DT.40312749  DT.95268878  DT.97823319  DT.100712294  DT.100788641  DT.313043 

    24/727 AceView cDNA sequences (see all 727):

    AA251856 AA768732 AA280351 BE670191 F06377 CR601128 AA251855 AI093310 
    AA281847 BI830280 AI432419 AA292890 BM701727 AI470737 BE047297 CA310789 
    AA595792 AA437249 BU507955 BU678895 CD722576 AI650961 AU137881 C20702 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for SPDYA (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^
    SP1:                                      -                       -           -     -     -                       -                 -     -                     
    SP2:                                -     -                       -           -     -     -                       -                 -     -                     
    SP3:                                -     -     -     -     -     -           -     -     -                       -                 -     -                     
    SP4:                    -     -     -     -                       -           -     -     -                                                                     
    SP5:                                -     -     -     -     -     -           -           -                                                                     

    ExUns: 13a · 13b ^ 14a · 14b · 14c
    SP1:  -                           
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for SPDYA

    Expression
    for SPDYA gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPDYA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGCTTTAGGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SPDYA expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryOvigerous CordXX Germ CellsFemale Gametocytes, Germ Cells
    OvaryOvigerous CordOvary
    Reproductive SystemMesonephrosReproductive System
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SPDYA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPDYA

    SOURCE GeneReport for Unigene cluster: Hs.511956

    UniProtKB/Swiss-Prot: SPDYA_HUMAN, Q5MJ70
    Tissue specificity: Highly expressed in testis. Expressed at a low level in wide range of tissues including bone
    marrow, brain, heart, kidney, colon, liver, placenta, spleen, skeletal muscle, salivary gland, thyroid gland, thymus,
    trachea and uterus. Expressed at a slightly higher level in adrenal gland, cerebellum, small intestine, lung, prostate
    and trachea. Expression is cell cycle-dependent, being restricted to cells in G1/S phase

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    In Situ
    Assay Products:     
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    Orthologs
    for SPDYA gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for SPDYA gene from 4/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SPDYA6
    		 Uncharacterized protein
    		 64(a)
    		 1 ↔ 1
    		 3(8547370-8552674)
    lizard
    (Anolis carolinensis)    		 Reptilia SPDYA6
    		 --
    		 74(a)
    		 1 ↔ 1
    		 1(248297006-248301696)
    African clawed frog
    (Xenopus laevis)    		 Amphibia ls272 p33 ringo 75.53(n)    AJ133500.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.158952 Transcribed sequence with weak similarity to protein more 75.21(n)    BI979855.1 


    ENSEMBL Gene Tree for SPDYA (if available)
    TreeFam Gene Tree for SPDYA (if available) 

    Paralogs
    for SPDYA gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPDYA gene
    SPDYE42  SPDYC2  SPDYE12  SPDYE32  SPDYE2L2  SPDYE22  
    2 SIMAP similar genes for SPDYA using alignment to 3 protein entries:     SPDYA_HUMAN (see all proteins):
    SPY1    SPDYC

    SPDYA for paralogs           About GeneDecksing



    Genomic Variants
    for SPDYA gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/637 NCBI SNPs in SPDYA are shown (see all 637)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1868689571,2
    		--29031704(+) AAATTC/TGCCCC 2 -- us2k10--------
    rs1929000501,2
    		--29031732(+) AGGTGG/TTATCA 2 -- us2k10--------
    rs1149640991,2
    		F,--29031872(+) CACACC/AAACAT 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1398140971,2
    		--29031913(+) AGAACA/GCTCAA 2 -- us2k10--------
    rs1431567001,2
    		--29032012(+) ATTTGC/GTGGCT 2 -- us2k10--------
    rs777006811,2
    		C,F,--29032136(+) CTCACT/CGTGCC 2 -- us2k11Minor allele frequency- C:0.02WA 118
    rs76014131,2
    		C,F,A,H,--29032238(+) TCTGTG/ATTTTT 2 -- us2k128Minor allele frequency- A:0.29NA NS EA WA 2906
    rs780720751,2
    		F,--29032251(+) TGTAGC/GGGACA 2 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1844506831,2
    		--29032301(+) TTAATA/CATCAC 2 -- us2k10--------
    rs803195991,2
    		C,F,--29032314(+) CACCGG/TTACCT 2 -- us2k11Minor allele frequency- T:0.16WA 118

    HapMap Linkage Disequilibrium report for SPDYA (29005383 - 29073477 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SPDYA
         1 Indel: 58979

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    Disorders / Diseases
    for SPDYA gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SPDYA for disorders           About GeneDecksing

    OMIM gene information: 614029    OMIM disorders: --

    4 diseases for SPDYA:    About MalaCards
    hepatocellular carcinoma    thyroiditis    carcinoma    prostatitis


    Export disorders for SPDYA gene to outside databases

    Publications
    for SPDYA gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPDYA gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with SPDYA)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins. (PubMed id 15611625)1, 2, 3 Cheng A.... Solomon M.J. (2005)
    2. Human Spy1 promotes survival of mammalian cells following DNA damage. (PubMed id 12839962)1, 2, 3 Barnes E.A....Donoghue D.J. (2003)
    3. Human Speedy: a novel cell cycle regulator that enhances proliferation through activation of Cdk2. (PubMed id 11980914)1, 2, 3 Porter L.A.... Donoghue D.J. (2002)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Spy1 interacts with p27Kip1 to allow G1/S progression. (PubMed id 12972555)1, 2 Porter L.A.... Donoghue D.J. (2003)
    7. Expression and prognostic role of Spy1 as a novel cel l cycle protein in hepatocellular carcinoma. (PubMed id 19686732)1 Ke Q....Shen A. (2009)
    8. Cell cycle regulation of the mammalian CDK activator RINGO/Speedy A. (PubMed id 19622356)1 Dinarina A....Nebreda A.R. (2009)
    9. The atypical CDK activator Spy1 regulates the intrinsic DNA damage response and is dependent upon p53 to inhibit apoptosis. (PubMed id 19106603)1 McAndrew C.W....Donoghue D.J. (2009)
    10. Spy1 enhances phosphorylation and degradation of the cell cycle inhibitor p27. (PubMed id 17671428)1 McAndrew C.W....Donoghue D.J. (2007)

    External Searches for SPDYA gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SPDYA gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 245711 HGNC: 30613 AceView: PPP1CBandSPDY1 Ensembl:ENSG00000163806 euGenes: HUgn245711
    ECgene: SPDYA Kegg: 245711 H-InvDB: SPDYA

    Other Databases showing SPDYA gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SPDYA gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPDYA Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SPDYA gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SPDYA gene:
    Search GeneIP for patents involving SPDYA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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