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Aliases for SPDYA Gene

Aliases for SPDYA Gene

  • Speedy/RINGO Cell Cycle Regulator Family Member A 2 3
  • SPY1 3 4 6
  • Rapid Inducer Of G2/M Progression In Oocytes A 3 4
  • HSpy/Ringo A 3 4
  • Speedy-1 3 4
  • RINGO A 3 4
  • RINGOA 3 6
  • SPDY1 3 4
  • Speedy Homolog A (Xenopus Laevis) 2
  • Speedy Homolog 1 (Drosophila) 2
  • Speedy Homolog A 3
  • Speedy Protein A 3
  • RINGO3 3

External Ids for SPDYA Gene

Previous HGNC Symbols for SPDYA Gene

  • SPDY1

Previous GeneCards Identifiers for SPDYA Gene

  • GC02P028828
  • GC02P029007

Summaries for SPDYA Gene

GeneCards Summary for SPDYA Gene

SPDYA (Speedy/RINGO Cell Cycle Regulator Family Member A) is a Protein Coding gene. Among its related pathways are Oocyte meiosis and Oocyte meiosis. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is SPDYE3.

UniProtKB/Swiss-Prot for SPDYA Gene

  • Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1, CDK2 and CDKN1B/KIP1. Can activate CDK2 without promoting CDK2 phosphorylation. Mediates cell survival during the DNA damage process through activation of CDK2.

Gene Wiki entry for SPDYA Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPDYA Gene

Genomics for SPDYA Gene

Regulatory Elements for SPDYA Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SPDYA Gene

Start:
28,782,517 bp from pter
End:
28,850,611 bp from pter
Size:
68,095 bases
Orientation:
Plus strand

Genomic View for SPDYA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPDYA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPDYA Gene

Proteins for SPDYA Gene

  • Protein details for SPDYA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5MJ70-SPDYA_HUMAN
    Recommended name:
    Speedy protein A
    Protein Accession:
    Q5MJ70
    Secondary Accessions:
    • Q53R05
    • Q5MJ69

    Protein attributes for SPDYA Gene

    Size:
    313 amino acids
    Molecular mass:
    36463 Da
    Quaternary structure:
    • Interacts with CDK1, CDK2 and CDKN1B/KIP1. Found in a complex with both CDK2 and CDKN1B/KIP1.

    Alternative splice isoforms for SPDYA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPDYA Gene

Proteomics data for SPDYA Gene at MOPED

Post-translational modifications for SPDYA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPDYA Gene

No data available for DME Specific Peptides for SPDYA Gene

Domains for SPDYA Gene

Gene Families for SPDYA Gene

HGNC:
  • SPDY :Speedy homologs

Protein Domains for SPDYA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPDYA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5MJ70

UniProtKB/Swiss-Prot:

SPDYA_HUMAN :
  • Q5MJ70
Domain:
  • The C-terminus is required for CDK2-activation, but not CDK2-binding.
Family:
  • Belongs to the Speedy/Ringo family.
genes like me logo Genes that share domains with SPDYA: view

Function for SPDYA Gene

Molecular function for SPDYA Gene

UniProtKB/Swiss-Prot Function: Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1, CDK2 and CDKN1B/KIP1. Can activate CDK2 without promoting CDK2 phosphorylation. Mediates cell survival during the DNA damage process through activation of CDK2.

Gene Ontology (GO) - Molecular Function for SPDYA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IPI 11980914
genes like me logo Genes that share ontologies with SPDYA: view

Phenotypes for SPDYA Gene

GenomeRNAi human phenotypes for SPDYA:
genes like me logo Genes that share phenotypes with SPDYA: view

Animal Model Products

CRISPR Products

miRNA for SPDYA Gene

miRTarBase miRNAs that target SPDYA

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPDYA

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SPDYA Gene

Localization for SPDYA Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPDYA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPDYA Gene COMPARTMENTS Subcellular localization image for SPDYA gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2
extracellular 1
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SPDYA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11980914
genes like me logo Genes that share ontologies with SPDYA: view

Pathways for SPDYA Gene

SuperPathways for SPDYA Gene

genes like me logo Genes that share pathways with SPDYA: view

Pathways by source for SPDYA Gene

Gene Ontology (GO) - Biological Process for SPDYA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IDA 11980914
GO:0006974 cellular response to DNA damage stimulus IDA 12839962
GO:0007140 male meiosis ISS --
GO:0007275 multicellular organismal development IEA --
GO:0008284 positive regulation of cell proliferation IDA 11980914
genes like me logo Genes that share ontologies with SPDYA: view

Transcripts for SPDYA Gene

Unigene Clusters for SPDYA Gene

Speedy homolog A (Xenopus laevis):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPDYA

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SPDYA

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPDYA Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - -
SP7: - - -
SP8: - - - -
SP9: - -
SP10:
SP11: -
SP12:
SP13:

ExUns: 13a · 13b ^ 14a · 14b · 14c
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - -
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for SPDYA Gene

GeneLoc Exon Structure for
SPDYA
ECgene alternative splicing isoforms for
SPDYA

Expression for SPDYA Gene

mRNA expression in normal human tissues for SPDYA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPDYA Gene

This gene is overexpressed in Testis (26.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SPDYA Gene

SOURCE GeneReport for Unigene cluster for SPDYA Gene Hs.511956

mRNA Expression by UniProt/SwissProt for SPDYA Gene

Q5MJ70-SPDYA_HUMAN
Tissue specificity: Highly expressed in testis. Expressed at a low level in wide range of tissues including bone marrow, brain, heart, kidney, colon, liver, placenta, spleen, skeletal muscle, salivary gland, thyroid gland, thymus, trachea and uterus. Expressed at a slightly higher level in adrenal gland, cerebellum, small intestine, lung, prostate and trachea. Expression is cell cycle-dependent, being restricted to cells in G1/S phase.
genes like me logo Genes that share expressions with SPDYA: view

In Situ Assay Products

Orthologs for SPDYA Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPDYA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPDYA 35
  • 99.68 (n)
  • 99.68 (a)
SPDYA 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPDYA 35
  • 92.52 (n)
  • 88.78 (a)
SPDYA 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPDYA 35
  • 92.45 (n)
  • 90.29 (a)
SPDYA 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spdya 35
  • 88.06 (n)
  • 84.19 (a)
Spdya 16
Spdya 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPDYA 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spdya 35
  • 89.64 (n)
  • 86.22 (a)
chicken
(Gallus gallus)
Aves SPDYA 35
  • 70.71 (n)
  • 64.59 (a)
SPDYA 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPDYA 36
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ls27 35
tropical clawed frog
(Silurana tropicalis)
Amphibia spdya 35
  • 66.34 (n)
  • 64.82 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13761 35
zebrafish
(Danio rerio)
Actinopterygii Dr.15895 35
spdya 35
  • 67.92 (n)
  • 73.12 (a)
spdya 36
  • 53 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
Species with no ortholog for SPDYA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPDYA Gene

ENSEMBL:
Gene Tree for SPDYA (if available)
TreeFam:
Gene Tree for SPDYA (if available)

Paralogs for SPDYA Gene

Paralogs for SPDYA Gene

Selected SIMAP similar genes for SPDYA Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SPDYA: view

Variants for SPDYA Gene

Sequence variations from dbSNP and Humsavar for SPDYA Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs3924633 -- 28,821,290(+) cgcct(C/T)ccggg intron-variant
rs4436918 -- 28,822,457(+) ATATA(C/T)ATTAC intron-variant
rs4611608 -- 28,841,670(+) CTAAG(A/G)TTCTT intron-variant
rs4643492 -- 28,822,605(+) TCCTT(A/T)TTTAT intron-variant
rs6547881 -- 28,809,880(+) TATTA(C/T)GCAGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SPDYA Gene

Variant ID Type Subtype PubMed ID
nsv819532 CNV Loss 19587683

Relevant External Links for SPDYA Gene

HapMap Linkage Disequilibrium report
SPDYA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPDYA Gene

Disorders for SPDYA Gene

No disorders were found for SPDYA Gene.

No data available for UniProtKB/Swiss-Prot for SPDYA Gene

Publications for SPDYA Gene

  1. Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins. (PMID: 15611625) Cheng A. … Solomon M.J. (Cell Cycle 2005) 2 3 4
  2. Human Speedy: a novel cell cycle regulator that enhances proliferation through activation of Cdk2. (PMID: 11980914) Porter L.A. … Donoghue D.J. (J. Cell Biol. 2002) 2 3 4
  3. Human Spy1 promotes survival of mammalian cells following DNA damage. (PMID: 12839962) Barnes E.A. … Donoghue D.J. (Cancer Res. 2003) 2 3 4
  4. Spy1 interacts with p27Kip1 to allow G1/S progression. (PMID: 12972555) Porter L.A. … Donoghue D.J. (Mol. Biol. Cell 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SPDYA Gene

Sources for SPDYA Gene

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