SPDL1 Gene

Aliases
for SPDL1 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Summaries
for SPDL1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for SPDL1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000005.9  NT_023133.14  NC_018916.2  

SwitchGear Promoter luciferase reporter plasmid: SPDL1 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPDL1

SPDL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P169011:  view genomic region     (about GC identifiers)

Proteins
for SPDL1 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for SPDL1: NX_Q96EA4

Explore proteomics data for SPDL1 at MOPED

Post-translational modifications: 

SPDL1 Human Recombinant Protein Products:

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	antibodies-online proteins for SPDL1 (4 products)
	antibodies-online peptides for SPDL1

SPDL1 Antibody Products:

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	antibodies-online antibodies for SPDL1 (27 products)

SPDL1 Assay Products:

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	Search eBioscience for ELISAs for SPDL1
	antibodies-online kits for SPDL1 (8 products)

Domains /
Families
for SPDL1 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q96EA4

Find genes that share domains with SPDL1           About GenesLikeMe

Function
for SPDL1 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for SPDL1

miRNA Products:		miRTarBase miRNAs that target SPDL1: hsa-mir-124-3p (MIRT004899)
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		SwitchGear 3'UTR luciferase reporter plasmid: SPDL1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for SPDL1
		Predesigned siRNA for gene silencing in human, mouse, rat SPDL1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for SPDL1

Clone Products:		OriGene clones in human, mouse for SPDL1 (see all 7) OriGene ORF clones in mouse, rat for SPDL1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPDL1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPDL1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SPDL1
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPDL1

Localization
for SPDL1 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 5 cellular component terms:    About this table

Pathways & Interactions
for SPDL1 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for SPDL1 About     See pathways by source

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	SuperPath	Contained pathways About
1	Mitotic Metaphase and Anaphase	Separation of Sister Chromatids 0.94 Mitotic Metaphase and Anaphase 0.93 Mitotic Anaphase 0.94
2	Cell Cycle, Mitotic	Cell Cycle, Mitotic 0.90 M Phase 0.62 Cell Cycle 0.90
3	Mitotic Prometaphase	Mitotic Prometaphase 0.92 Resolution of Sister Chromatid Cohesion 0.92

3 Reactome Pathways for SPDL1

	Resolution of Sister Chromatid Cohesion
	Mitotic Prometaphase
	Separation of Sister Chromatids

Gene Ontology (GO): 5 biological process terms:    About this table

Drugs & Compounds
for SPDL1 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for SPDL1 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for SPDL1 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SPDL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

Primer Products:		OriGene qPCR primer pairs and template standards for SPDL1 OriGene qSTAR qPCR primer pairs in human, mouse for SPDL1
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		QuantiFast Probe-based Assays in human, mouse, rat SPDL1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPDL1

Orthologs
for SPDL1 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for SPDL1 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Genomic Variants
for SPDL1 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SPDL1 (see all 570)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1453456081,2		--	169008684(+)	GTATTC/TAGGCC	1	--	us2k1		0	--	--	--	--
rs176444171,2	C,F	--	169008697(+)	GGTATG/TCGGAC	1	--	us2k1		6		NA WA	380
rs733124841,2	C,F	--	169008734(+)	TGGTAT/CTGTGA	1	--	us2k1		2		WA	120
rs597160351,2	C,F	--	169008771(+)	AAAGTG/AGAACC	1	--	us2k1		1		WA	2
rs1138898531,2	F	--	169008810(+)	CTAGCG/ATCCAG	1	--	us2k1		1		CSA	2
rs1390614691,2		--	169008907(+)	GCTGTA/CCCCTC	1	--	us2k1		0	--	--	--	--
rs1887663311,2		--	169008908(+)	CTGTCC/TCCTCC	1	--	us2k1		0	--	--	--	--
rs1540351,2	C,F,O,A,H	--	169009060(-)	TGCTAC/TGCAAG	1	--	us2k1		34		NA EA MN NS WA CSA	3341
rs1811582471,2		--	169009336(+)	TTGGCC/GTAAGC	1	--	us2k1		0	--	--	--	--
rs170714741,2	C,F,H	--	169009448(+)	ATGAAT/CGAGCA	1	--	us2k1		10		NA NS	1402

HapMap Linkage Disequilibrium report for SPDL1 (169010638 - 169031782 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for SPDL1: --

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing SPDL1

DNA2.0 Custom Variant and Variant Library Synthesis for SPDL1

Disorders / Diseases
for SPDL1 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for SPDL1 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Spindly/CCDC99 is required for efficient chromosome congression and mitotic checkpoint regulation. (PubMed id 20427577)^{1, 3} Barisic M....Geley S. (Mol. Biol. Cell 2010)
2. Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly. (PubMed id 19468067)^{1, 2} Chan Y.W.... Santamaria A. (J. Cell Biol. 2009)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
5. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. (PubMed id 23382074)¹ Armour S.M....Sinclair D.A. (Mol. Cell. Biol. 2013)
6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)¹ Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
7. A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (Cell 2012)
8. Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks. (PubMed id 22558309)¹ Wong K.A....O'Bryan J.P. (PLoS ONE 2012)
9. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (Nat. Methods 2012)
10. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)² Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)

External Searches for SPDL1 gene

Genome Databases showing SPDL1 gene

Other Databases showing SPDL1 gene

Specialized Databases showing SPDL1 gene

Products
for SPDL1 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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