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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SPDL1 Gene

protein-coding GIFtS: 45
GCID: GC05P169011

Spindle Apparatus Coiled-Coil Protein 1

(Previous name: coiled-coil domain containing 99)
(Previous symbol: CCDC99)

1 related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Spindle Apparatus Coiled-Coil Protein 1¹ ²		Spindle Apparatus Coiled-Coil Domain-Containing Protein 1² ³
CCDC99¹ ² ³		hSpindly² ³
Coiled-Coil Domain Containing 99¹ ²		Spindly Homolog (Drosophila)¹
Arsenite-Related Gene 1 Protein² ³		Protein Spindly²
Coiled-Coil Domain-Containing Protein 99² ³		Rrhabdomyosarcoma Antigen Protein MU-RMS-40.4A²
Rhabdomyosarcoma Antigen MU-RMS-40.4A² ³		Spindly Homolog²

External Ids:	HGNC: 26010¹	Entrez Gene: 54908²	Ensembl: ENSG00000040275⁷	UniProtKB: Q96EA4³

Export aliases for SPDL1 gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SPDL1 Gene:

SPDL1 (spindle apparatus coiled-coil protein 1) is a protein-coding gene. Diseases associated with SPDL1 include rhabdomyosarcoma, and among its related super-pathways are Mitotic Anaphase and Mitotic Prometaphase. GO annotations related to this gene include protein binding and kinetochore binding.

UniProtKB/Swiss-Prot: SPDLY_HUMAN, Q96EA4

Function: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to

control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the

subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required

for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint

(SAC) proteins from the kinetochore upon bipolar spindle attachment

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NT_023133.13 NC_018916.2

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for SPDL1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SPDL1 promoter sequence

Search SABiosciences Chromatin IP Primers for SPDL1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPDL1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.1 Ensembl cytogenetic band: 5q35.1 HGNC cytogenetic band: 5q35.1

SPDL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPDL1 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P169011: view genomic region (about GC identifiers)

Start:	169,010,638 bp from pter	End:	169,031,782 bp from pter
Size:	21,145 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SPDLY_HUMAN, Q96EA4 (See protein sequence)

Recommended Name: Protein Spindly

Size: 605 amino acids; 70172 Da

Subunit: Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect

Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere,

kinetochore. Nucleus. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the nucleus in interphase and to

the kinetochore in early prometaphase. Relocalizes to the mitotic spindle pole before metaphase and is

subsequently lost from the spindle poles after chromosome congression is completed. Removal of this protein from

the kinetochore requires the dynein/dynactin complex

Sequence caution: Sequence=AAG01408.1; Type=Frameshift; Positions=604; Sequence=BAA91119.1; Type=Frameshift;

Positions=412; Sequence=BAB85022.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: C9JS47 Q8TEC8 Q9HD44 Q9NX97

Alternative splicing: 2 isoforms: Q96EA4-1 Q96EA4-2

Explore the universe of human proteins at neXtProt for SPDL1: NX_Q96EA4

Explore proteomics data for SPDL1 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q96EA4

SPDL1 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_060255.3

ENSEMBL proteins:

ENSP00000265295 ENSP00000421598 ENSP00000423687 ENSP00000425357 ENSP00000425922

ENSP00000422352 ENSP00000427197 ENSP00000426965 ENSP00000427510 ENSP00000426881

ENSP00000429470

Reactome Protein details: Q96EA4
Human Recombinant Protein Products for SPDL1:

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	Browse Proteins at Cloud-Clone Corp.

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000922	spindle pole	IDA	19468067
GO:0000940	condensed chromosome outer kinetochore	IDA	19468067
GO:0005634	nucleus	IDA	19468067
GO:0005815	microtubule organizing center	IEA	--
GO:0005829	cytosol	TAS	--

SPDL1 for ontologies About GeneDecksing

SPDL1 Antibody Products:

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	Novus Biologicals SPDL1 Antibodies
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	LSBio Antibodies in human, mouse, rat for SPDL1

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	Browse Kits and Assays available from EMD Millipore
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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q96EA4

UniProtKB/Swiss-Prot: SPDLY_HUMAN, Q96EA4

Similarity: Belongs to the Spindly family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SPDLY_HUMAN, Q96EA4

Function: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to

control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the

subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required

for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint

(SAC) proteins from the kinetochore upon bipolar spindle attachment

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	19468067
GO:0043515	kinetochore binding	IDA	19468067

SPDL1 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for SPDL1:

Decreased Hepatitis C virus re

Increased gamma-H2AX phosphory

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for SPDL1

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SPDL1

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPDL1

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPDL1

miRNA Products:		miRTarBase miRNAs that target SPDL1: hsa-mir-124 (MIRT004899)

		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPDL1
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		SwitchGear 3'UTR luciferase reporter plasmid: SPDL1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for SPDL1
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SPDL1
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPDL1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for SPDL1 About

See pathways by source

SuperPath

Contained pathways About

M Phase

Mitotic Anaphase	0.94	M Phase	0.88
Separation of Sister Chromatids	0.94	Mitotic M-M/G1 phases	0.88
Mitotic Metaphase and Anaphase	0.94

Resolution of Sister Chromatid Cohesion

Resolution of Sister Chromatid Cohesion

0.93

Mitotic Prometaphase

0.93

Cell Cycle

Cell Cycle, Mitotic

0.84

Cell Cycle

0.84

Pathways by source See SuperPaths
Show all pathways

5/9 Reactome Pathways for SPDL1 (see all 9)

	Mitotic Metaphase and Anaphase
	Mitotic Prometaphase
	Resolution of Sister Chromatid Cohesion
	Mitotic Anaphase
	Cell Cycle

SPDL1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SPDL1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/76 Interacting proteins for SPDL1 (Q96EA4^{2, 3} ENSP00000265295⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 76)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KIAA1377	Q9P2H0²^,³, ENSP00000263468⁴	MINT-65131 I2D: score=5 STRING: ENSP00000263468
GPS2	Q13227²^,³	MINT-65130 I2D: score=5
AURKB	ENSP00000313950⁴	STRING: ENSP00000313950
BIRC5	ENSP00000301633⁴	STRING: ENSP00000301633
BUB1	ENSP00000302530⁴	STRING: ENSP00000302530

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000132	establishment of mitotic spindle orientation	IMP	19468067
GO:0000278	mitotic cell cycle	TAS	--
GO:0007080	mitotic metaphase plate congression	IMP	19468067
GO:0034501	protein localization to kinetochore	IMP	19468067
GO:0051301	cell division	IEA	--

SPDL1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SPDL1 (SPDLY)

Search CenterWatch for drugs/clinical trials and news about SPDL1 / SPDLY

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SPDL1 gene:

NM_017785.4

Unigene Cluster for SPDL1:

Spindle apparatus coiled-coil protein 1

Hs.368710 [show with all ESTs]

Unigene Representative Sequence: NM_017785

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000265295(uc003mae.4 uc011deq.2 uc010jjk.3) ENST00000506574

ENST00000515224 ENST00000507232(uc010jjj.3) ENST00000510751 ENST00000508247

ENST00000503209 ENST00000513941 ENST00000509785 ENST00000512028 ENST00000513795

ENST00000508837 ENST00000503871 ENST00000505977 ENST00000523518

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPDL1
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Search SABiosciences RT² qPCR Primer Assays in human, mouse, rat SPDL1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPDL1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPDL1

Additional mRNA sequence:

AF269167.1 AK000371.1 AK074227.1 AK304623.1 AK308835.1 AK310442.1 AY517557.1 BC012568.1

10 DOTS entries:

DT.444072 DT.100787970 DT.403971 DT.100787968 DT.120844459 DT.120844464 DT.120844471 DT.95102763

DT.97767556 DT.99998497

24/109 AceView cDNA sequences (see all 109):

CB120621 BQ893070 AI696342 BP363070 AA748832 AL601942 AI553994 CB143878

BU188489 AI281372 AW103190 BM474437 AW449119 AI080472 BF980745 AI467913

AW513433 AI753556 AI083567 BF435797 AW025690 AA258189 AI217414 AL705318

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SPDL1 (see all 6) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	·	7c	·	7d	^	8	^	9	^	10a	·	10b	^	11	^	12	^	13	^	14	^	15
SP1:									-
SP2:									-												-		-		-
SP3:
SP4:
SP5:							-		-

ECgene alternative splicing isoforms for SPDL1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SPDL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

See SPDL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPDL1

SOURCE GeneReport for Unigene cluster: Hs.368710

SABiosciences Custom PCR Arrays for SPDL1

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPDL1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SPDL1 gene from 6/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Spdl1⁵ Ccdc99¹	coiled-coil domain containing 99^{1, 5}	77.11(n)¹ 74.3(a)¹		11 (19.90 cM)⁵ 70385¹ NM_027411.2¹ NP_081687.2¹ 34809190⁵
chicken (Gallus gallus)	Aves	CCDC99¹	coiled-coil domain containing 99	66.89(n) 60.83(a)		416172 XM_414505.3 XP_414505.1
lizard (Anolis carolinensis)	Reptilia	SPDL1⁶	spindle apparatus coiled-coil protein 1	52(a)	1 ↔ 1	2(120099637-120126544)
African clawed frog (Xenopus laevis)	Amphibia	Xl.9016²	Xenopus laevis transcribed sequence with weak similarity more	76(n)		CA972378.1
zebrafish (Danio rerio)	Actinopterygii	zgc:171223¹	zgc:171223	55.8(n) 48.54(a)		568360 NM_001104942.1 NP_001098412.1
fruit fly (Drosophila melanogaster)	Insecta	Spindly⁶	Spindly	9(a)	1 ↔ 1	2L(3527387-3530317)

ENSEMBL Gene Tree for SPDL1 (if available)
TreeFam Gene Tree for SPDL1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs145345608^1,2		--	169008684(+)	`GTATTC/TAGGCC`	1	--	us2k¹		0	--	--	--	--
rs17644417^1,2	C,F	--	169008697(+)	`GGTATG/TCGGAC`	1	--	us2k¹		6		NA WA	380
rs73312484^1,2	C,F	--	169008734(+)	`TGGTAT/CTGTGA`	1	--	us2k¹		2		WA	120
rs59716035^1,2	C,F	--	169008771(+)	`AAAGTG/AGAACC`	1	--	us2k¹		1		WA	2
rs113889853^1,2	F	--	169008810(+)	`CTAGCG/ATCCAG`	1	--	us2k¹		1		CSA	2
rs139061469^1,2		--	169008907(+)	`GCTGTA/CCCCTC`	1	--	us2k¹		0	--	--	--	--
rs188766331^1,2		--	169008908(+)	`CTGTCC/TCCTCC`	1	--	us2k¹		0	--	--	--	--
rs154035^1,2	C,F,O,A,H	--	169009060(-)	`TGCTAC/TGCAAG`	1	--	us2k¹		34		NA EA MN NS WA CSA	3341
rs181158247^1,2		--	169009336(+)	`TTGGCC/GTAAGC`	1	--	us2k¹		0	--	--	--	--
rs17071474^1,2	C,F,H	--	169009448(+)	`ATGAAT/CGAGCA`	1	--	us2k¹		10		NA NS	1402

HapMap Linkage Disequilibrium report for SPDL1 (169010638 - 169031782 bp)

Structural Variations
Database of Genomic Variants (DGV) variations for SPDL1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPDL1

DNA2.0 Custom Variant and Variant Library Synthesis for SPDL1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

2 diseases for SPDL1: About MalaCards

rhabdomyosarcoma

SPDL1 for disorders About GeneDecksing

Export disorders for SPDL1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SPDL1 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with SPDL1)

Utopia: connect your pdf to the dynamic
world of online information

Spindly/CCDC99 is required for efficient chromosome c ongression and mitotic checkpoint regulation. (PubMed id 20427577)^{1, 3} Barisic M....Geley S. (2010)
Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly. (PubMed id 19468067)^{1, 2} Chan Y.W.... Santamaria A. (2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. (PubMed id 23382074)¹ Armour S.M....Sinclair D.A. (2013)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Intersectin (ITSN) family of scaffolds function as mol ecular hubs in protein interaction networks. (PubMed id 22558309)¹ Wong K.A....O'Bryan J.P. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 54908	HGNC: 26010	AceView: FLJ20364	Ensembl:ENSG00000040275	euGenes: HUgn54908
ECgene: SPDL1	H-InvDB: SPDL1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SPDL1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SPDL1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SPDL1 gene:
Search GeneIP for patents involving SPDL1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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SPDL1 Gene

Spindle Apparatus Coiled-Coil Protein 1

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SPDL1 Gene

Spindle Apparatus Coiled-Coil Protein 1

Aliasesfor SPDL1 gene

Summariesfor SPDL1 gene

Genomic Viewsfor SPDL1 gene

Proteinsfor SPDL1 gene

Protein Domains /Familiesfor SPDL1 gene

Functionfor SPDL1 gene

Pathways & Interactionsfor SPDL1 gene

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for SPDL1 gene

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for SPDL1 gene

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for SPDL1 gene

Pathways & Interactions
for SPDL1 gene

Drugs & Compounds
for SPDL1 gene

Transcripts
for SPDL1 gene

Expression
for SPDL1 gene

Orthologs
for SPDL1 gene

Paralogs
for SPDL1 gene

Genomic Variants
for SPDL1 gene

Disorders / Diseases
for SPDL1 gene

Publications
for SPDL1 gene

Intellectual Property
for SPDL1 gene

Products
for SPDL1 gene