Aliases for SPDL1 Gene
External Ids for SPDL1 Gene
Previous Symbols for SPDL1 Gene
GeneCards Summary for SPDL1 Gene
SPDL1 (Spindle Apparatus Coiled-Coil Protein 1) is a Protein Coding gene. Diseases associated with SPDL1 include rhabdomyosarcoma. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include kinetochore binding.
UniProtKB/Swiss-Prot for SPDL1 Gene
Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment.