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SPDL1 Gene

protein-coding   GIFtS: 44
GCID: GC05P169011

Spindle Apparatus Coiled-Coil Protein 1

(Previous name: coiled-coil domain containing 99)
(Previous symbol: CCDC99)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Spindle Apparatus Coiled-Coil Protein 11 2     Spindle Apparatus Coiled-Coil Domain-Containing Protein 12 3
CCDC991 2 3     hSpindly2 3
Coiled-Coil Domain Containing 991 2     Spindly Homolog (Drosophila)1
Arsenite-Related Gene 1 Protein2 3     Protein Spindly2
Coiled-Coil Domain-Containing Protein 992 3     Rrhabdomyosarcoma Antigen Protein MU-RMS-40.4A2
Rhabdomyosarcoma Antigen MU-RMS-40.4A2 3     Spindly Homolog2

External Ids:    HGNC: 260101   Entrez Gene: 549082   Ensembl: ENSG000000402757   UniProtKB: Q96EA43   

Export aliases for SPDL1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SPDL1 Gene:
SPDL1 (spindle apparatus coiled-coil protein 1) is a protein-coding gene. Diseases associated with SPDL1 include rhabdomyosarcoma. GO annotations related to this gene include kinetochore binding.

UniProtKB/Swiss-Prot: SPDLY_HUMAN, Q96EA4
Function: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to
control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the
subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required
for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint
(SAC) proteins from the kinetochore upon bipolar spindle attachment




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_023133.14  NC_018916.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SPDL1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPDL1 promoter sequence
   Search Chromatin IP Primers for SPDL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPDL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.1   Ensembl cytogenetic band:  5q35.1   HGNC cytogenetic band: 5q35.1

SPDL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPDL1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P169011:  view genomic region     (about GC identifiers)

Start:
169,010,638 bp from pter      End:
169,031,782 bp from pter
Size:
21,145 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SPDLY_HUMAN, Q96EA4 (See protein sequence)
Recommended Name: Protein Spindly  
Size: 605 amino acids; 70172 Da
Subunit: Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect
Sequence caution: Sequence=AAG01408.1; Type=Frameshift; Positions=604; Sequence=BAA91119.1; Type=Frameshift;
Positions=412; Sequence=BAB85022.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: C9JS47 Q8TEC8 Q9HD44 Q9NX97
Alternative splicing: 2 isoforms:  Q96EA4-1   Q96EA4-2   

Explore the universe of human proteins at neXtProt for SPDL1: NX_Q96EA4

Explore proteomics data for SPDL1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SPDL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060255.3  
    ENSEMBL proteins: 
     ENSP00000265295   ENSP00000421598   ENSP00000423687   ENSP00000425357   ENSP00000425922  
     ENSP00000422352   ENSP00000427197   ENSP00000426965   ENSP00000427510   ENSP00000426881  
     ENSP00000429470  
    Reactome Protein details: Q96EA4

    SPDL1 Human Recombinant Protein Products:

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    Novus Biologicals SPDL1 Protein
    Novus Biologicals SPDL1 Lysate
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR028593 SPDLY_chordates

    Graphical View of Domain Structure for InterPro Entry Q96EA4

    ProtoNet protein and cluster: Q96EA4

    UniProtKB/Swiss-Prot: SPDLY_HUMAN, Q96EA4
    Similarity: Belongs to the Spindly family


    SPDL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPDLY_HUMAN, Q96EA4
    Function: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to
    control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the
    subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required
    for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint
    (SAC) proteins from the kinetochore upon bipolar spindle attachment

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19468067
    GO:0043515kinetochore binding IDA19468067
         
    SPDL1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SPDL1:
     Decreased Hepatitis C virus re  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPDL1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPDL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPDL1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SPDL1:
    hsa-mir-124-3p (MIRT004899)

    Block miRNA regulation of human, mouse, rat SPDL1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SPDL1
    SwitchGear 3'UTR luciferase reporter plasmidSPDL1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SPDL1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPDL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPDLY_HUMAN, Q96EA4: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere,
    kinetochore. Nucleus. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the nucleus in interphase and to
    the kinetochore in early prometaphase. Relocalizes to the mitotic spindle pole before metaphase and is
    subsequently lost from the spindle poles after chromosome congression is completed. Removal of this protein from
    the kinetochore requires the dynein/dynactin complex

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IDA19468067
    GO:0000940condensed chromosome outer kinetochore IDA19468067
    GO:0005634nucleus IDA19468067
    GO:0005815microtubule organizing center IEA--
    GO:0005829cytosol TAS--

    SPDL1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SPDL1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    3Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Reactome Pathways for SPDL1
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Separation of Sister Chromatids



    SPDL1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPDL1
    Interactions:

        Search GeneGlobe Interaction Network for SPDL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SPDL1 (Q96EA42, 3 ENSP000002652954) via UniProtKB, MINT, STRING, and/or I2D (see all 91)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KIAA1377Q9P2H02, 3, ENSP000002634684MINT-65131 I2D: score=5 STRING: ENSP00000263468
    GPS2Q132272, 3MINT-65130 I2D: score=5 
    AURKBENSP000003139504STRING: ENSP00000313950
    BIRC5ENSP000003016334STRING: ENSP00000301633
    BUB1ENSP000003025304STRING: ENSP00000302530
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000132establishment of mitotic spindle orientation IMP19468067
    GO:0000278mitotic cell cycle TAS--
    GO:0007080mitotic metaphase plate congression IMP19468067
    GO:0031577spindle checkpoint IEA--
    GO:0034501protein localization to kinetochore IMP19468067

    SPDL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPDL1 (SPDLY)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SPDL1 gene: 
    NM_017785.4  

    Unigene Cluster for SPDL1:

    Spindle apparatus coiled-coil protein 1
    Hs.368710  [show with all ESTs]
    Unigene Representative Sequence: NM_017785
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265295(uc003mae.4 uc011deq.2 uc010jjk.3) ENST00000506574
    ENST00000515224 ENST00000507232(uc010jjj.3) ENST00000510751 ENST00000508247
    ENST00000503209 ENST00000513941 ENST00000509785 ENST00000512028 ENST00000513795
    ENST00000508837 ENST00000503871 ENST00000505977 ENST00000523518
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidSPDL1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SPDL1
    Predesigned siRNA for gene silencing in human, mouse, rat SPDL1
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    Primer
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    OriGene qPCR primer pairs and template standards for SPDL1
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    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat SPDL1
      QuantiTect SYBR Green Assays in human, mouse, rat SPDL1
      QuantiFast Probe-based Assays in human, mouse, rat SPDL1

    Additional mRNA sequence: 

    AF269167.1 AK000371.1 AK074227.1 AK304623.1 AK308835.1 AK310442.1 AY517557.1 BC012568.1 

    10 DOTS entries:

    DT.444072  DT.100787970  DT.403971  DT.100787968  DT.120844459  DT.120844464  DT.120844471  DT.95102763 
    DT.97767556  DT.99998497 

    Selected AceView cDNA sequences (see all 109):

    AI217414 AA258189 AI080472 BP363070 AI553994 AW025690 BQ230141 AI467913 
    BF435797 BQ893070 AI281372 AL705318 BF980745 AI753556 AW449119 CB120621 
    AI083567 AL601942 AW103190 AW513433 BU188489 AI696342 AA748832 CB143878 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SPDL1 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                          -                                                                                       
    SP2:                          -                                   -     -     -                                       
    SP3:                                                                                                                  
    SP4:                                                                                                                  
    SP5:                    -     -                                                                                       


    ECgene alternative splicing isoforms for SPDL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SPDL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SPDL1 Expression
    About this image

    SPDL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPDL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.368710
        Custom PCR Arrays for SPDL1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPDL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SPDL1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spdl11 , 5 coiled-coil domain containing 995
    spindle apparatus coiled-coil protein 11
    77.34(n)1
    74.3(a)1
      11 (19.90 cM)5
    703851  NM_027411.21  NP_081687.21 
     348091905 
    chicken
    (Gallus gallus)
    Aves CCDC991 coiled-coil domain containing 99 66.94(n)
    60.83(a)
      416172  XM_004944788.1  XP_004944845.1 
    lizard
    (Anolis carolinensis)
    Reptilia SPDL16
    spindle apparatus coiled-coil protein 1
    53(a)
    1 ↔ 1
    2(120099637-120126544)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.90162 Xenopus laevis transcribed sequence with weak similarity more 76(n)    CA972378.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1712231 zgc:171223 57.07(n)
    50.96(a)
      568360  NM_001104942.1  NP_001098412.1 


    ENSEMBL Gene Tree for SPDL1 (if available)
    TreeFam Gene Tree for SPDL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SPDL1 (see all 570)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1453456081,2
    --169008684(+) GTATTC/TAGGCC 1 -- us2k10--------
    rs176444171,2
    C,F--169008697(+) GGTATG/TCGGAC 1 -- us2k16Minor allele frequency- T:0.04NA WA 380
    rs733124841,2
    C,F--169008734(+) TGGTAT/CTGTGA 1 -- us2k12Minor allele frequency- C:0.06WA 120
    rs597160351,2
    C,F--169008771(+) AAAGTG/AGAACC 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1138898531,2
    F--169008810(+) CTAGCG/ATCCAG 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1390614691,2
    --169008907(+) GCTGTA/CCCCTC 1 -- us2k10--------
    rs1887663311,2
    --169008908(+) CTGTCC/TCCTCC 1 -- us2k10--------
    rs1540351,2
    C,F,O,A,H--169009060(-) TGCTAC/TGCAAG 1 -- us2k134Minor allele frequency- T:0.38NA EA MN NS WA CSA 3341
    rs1811582471,2
    --169009336(+) TTGGCC/GTAAGC 1 -- us2k10--------
    rs170714741,2
    C,F,H--169009448(+) ATGAAT/CGAGCA 1 -- us2k110Minor allele frequency- C:0.03NA NS 1402

    HapMap Linkage Disequilibrium report for SPDL1 (169010638 - 169031782 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SPDL1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SPDL1
    DNA2.0 Custom Variant and Variant Library Synthesis for SPDL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for SPDL1:    About MalaCards
    rhabdomyosarcoma


    SPDL1 for disorders           About GeneDecksing


    Export disorders for SPDL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SPDL1 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with SPDL1)
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    1. Spindly/CCDC99 is required for efficient chromosome congression and mitotic checkpoint regulation. (PubMed id 20427577)1, 3 Barisic M....Geley S. (Mol. Biol. Cell 2010)
    2. Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly. (PubMed id 19468067)1, 2 Chan Y.W.... Santamaria A. (J. Cell Biol. 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. (PubMed id 23382074)1 Armour S.M....Sinclair D.A. (Mol. Cell. Biol. 2013)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks. (PubMed id 22558309)1 Wong K.A....O'Bryan J.P. (PLoS ONE 2012)
    9. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    10. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54908 HGNC: 26010 AceView: FLJ20364 Ensembl:ENSG00000040275 euGenes: HUgn54908
    ECgene: SPDL1 H-InvDB: SPDL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SPDL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SPDL1 gene:
    Search GeneIP for patents involving SPDL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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