Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SPDL1 Gene

Aliases for SPDL1 Gene

  • Spindle Apparatus Coiled-Coil Protein 1 2 3
  • Spindle Apparatus Coiled-Coil Domain-Containing Protein 1 3 4
  • Coiled-Coil Domain-Containing Protein 99 3 4
  • Rhabdomyosarcoma Antigen MU-RMS-40.4A 3 4
  • Coiled-Coil Domain Containing 99 2 3
  • Arsenite-Related Gene 1 Protein 3 4
  • HSpindly 3 4
  • CCDC99 3 4
  • Rrhabdomyosarcoma Antigen Protein MU-RMS-40.4A 3
  • Spindly Homolog (Drosophila) 2
  • Protein Spindly 3
  • Spindly Homolog 3

External Ids for SPDL1 Gene

Previous HGNC Symbols for SPDL1 Gene

  • CCDC99

Previous GeneCards Identifiers for SPDL1 Gene

  • GC05P169011

Summaries for SPDL1 Gene

GeneCards Summary for SPDL1 Gene

SPDL1 (Spindle Apparatus Coiled-Coil Protein 1) is a Protein Coding gene. Diseases associated with SPDL1 include rhabdomyosarcoma. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include kinetochore binding.

UniProtKB/Swiss-Prot for SPDL1 Gene

  • Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPDL1 Gene

Genomics for SPDL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SPDL1 Gene

Start:
169,583,634 bp from pter
End:
169,604,778 bp from pter
Size:
21,145 bases
Orientation:
Plus strand

Genomic View for SPDL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPDL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPDL1 Gene

No data available for Regulatory Elements for SPDL1 Gene

Proteins for SPDL1 Gene

  • Protein details for SPDL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EA4-SPDLY_HUMAN
    Recommended name:
    Protein Spindly
    Protein Accession:
    Q96EA4
    Secondary Accessions:
    • B4E393
    • C9JS47
    • Q8TEC8
    • Q9HD44
    • Q9NX97

    Protein attributes for SPDL1 Gene

    Size:
    605 amino acids
    Molecular mass:
    70172 Da
    Quaternary structure:
    • Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect.
    SequenceCaution:
    • Sequence=AAG01408.1; Type=Frameshift; Positions=604; Evidence={ECO:0000305}; Sequence=BAA91119.1; Type=Frameshift; Positions=412; Evidence={ECO:0000305}; Sequence=BAB85022.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SPDL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPDL1 Gene

Proteomics data for SPDL1 Gene at MOPED

Post-translational modifications for SPDL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SPDL1 Gene

Domains for SPDL1 Gene

Protein Domains for SPDL1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96EA4

UniProtKB/Swiss-Prot:

SPDLY_HUMAN :
  • Q96EA4
Family:
  • Belongs to the Spindly family.
genes like me logo Genes that share domains with SPDL1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for SPDL1 Gene

Function for SPDL1 Gene

Molecular function for SPDL1 Gene

UniProtKB/Swiss-Prot Function: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment.

Gene Ontology (GO) - Molecular Function for SPDL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19468067
GO:0019899 enzyme binding IPI 23382074
GO:0043515 kinetochore binding IDA 19468067
genes like me logo Genes that share ontologies with SPDL1: view

Phenotypes for SPDL1 Gene

genes like me logo Genes that share phenotypes with SPDL1: view

Animal Model Products

CRISPR Products

miRNA for SPDL1 Gene

miRTarBase miRNAs that target SPDL1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPDL1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SPDL1 Gene

Localization for SPDL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPDL1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the nucleus in interphase and to the kinetochore in early prometaphase. Relocalizes to the mitotic spindle pole before metaphase and is subsequently lost from the spindle poles after chromosome congression is completed. Removal of this protein from the kinetochore requires the dynein/dynactin complex.

Gene Ontology (GO) - Cellular Components for SPDL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 19468067
GO:0000940 condensed chromosome outer kinetochore IDA 19468067
GO:0005634 nucleus IDA 19468067
GO:0005815 microtubule organizing center IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SPDL1: view

No data available for Subcellular locations from COMPARTMENTS for SPDL1 Gene

Pathways for SPDL1 Gene

genes like me logo Genes that share pathways with SPDL1: view

Pathways by source for SPDL1 Gene

Gene Ontology (GO) - Biological Process for SPDL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000132 establishment of mitotic spindle orientation IMP 19468067
GO:0000278 mitotic cell cycle TAS --
GO:0007080 mitotic metaphase plate congression IMP 19468067
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0031577 spindle checkpoint IEA --
genes like me logo Genes that share ontologies with SPDL1: view

Transcripts for SPDL1 Gene

Unigene Clusters for SPDL1 Gene

Spindle apparatus coiled-coil protein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPDL1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPDL1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: -
SP2: - - - -
SP3:
SP4:
SP5: - -
SP6:

Relevant External Links for SPDL1 Gene

GeneLoc Exon Structure for
SPDL1
ECgene alternative splicing isoforms for
SPDL1

Expression for SPDL1 Gene

mRNA expression in normal human tissues for SPDL1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SPDL1 Gene

SOURCE GeneReport for Unigene cluster for SPDL1 Gene Hs.368710

genes like me logo Genes that share expressions with SPDL1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SPDL1 Gene

Orthologs for SPDL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPDL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPDL1 35
  • 99.39 (n)
  • 99.01 (a)
SPDL1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPDL1 35
  • 87.4 (n)
  • 84.08 (a)
SPDL1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPDL1 35
  • 90.22 (n)
  • 87.89 (a)
SPDL1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spdl1 35
  • 77.34 (n)
  • 74.3 (a)
Spdl1 16
Spdl1 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPDL1 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spdl1 35
  • 78.28 (n)
  • 74.41 (a)
chicken
(Gallus gallus)
Aves CCDC99 35
  • 66.94 (n)
  • 60.83 (a)
SPDL1 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPDL1 36
  • 53 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9016 35
tropical clawed frog
(Silurana tropicalis)
Amphibia spdl1 35
  • 61.28 (n)
  • 56.67 (a)
zebrafish
(Danio rerio)
Actinopterygii SPDL1 36
  • 46 (a)
OneToOne
zgc:171223 35
  • 57.07 (n)
  • 50.96 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToOne
Species with no ortholog for SPDL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPDL1 Gene

ENSEMBL:
Gene Tree for SPDL1 (if available)
TreeFam:
Gene Tree for SPDL1 (if available)

Paralogs for SPDL1 Gene

No data available for Paralogs for SPDL1 Gene

Variants for SPDL1 Gene

Sequence variations from dbSNP and Humsavar for SPDL1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs154033 -- 169,584,536(-) tttct(G/T)gttta intron-variant
rs154034 -- 169,584,109(-) CCAAC(C/G)TTCCA intron-variant, utr-variant-5-prime
rs154035 -- 169,582,056(-) TGCTA(C/T)GCAAG upstream-variant-2KB
rs255824 -- 169,587,297(-) TGAAC(A/G)AGTAT intron-variant, utr-variant-5-prime
rs918512 -- 169,599,351(+) TGTGC(A/C)TGAAT intron-variant

Relevant External Links for SPDL1 Gene

HapMap Linkage Disequilibrium report
SPDL1
Human Gene Mutation Database (HGMD)
SPDL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SPDL1 Gene

Disorders for SPDL1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SPDL1 Gene including...

Search for SPDL1 Gene in MalaCards »
genes like me logo Genes that share disorders with SPDL1: view

No data available for UniProtKB/Swiss-Prot for SPDL1 Gene

Publications for SPDL1 Gene

  1. Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly. (PMID: 19468067) Chan Y.W. … Santamaria A. (J. Cell Biol. 2009) 3 4
  2. Spindly/CCDC99 is required for efficient chromosome congression and mitotic checkpoint regulation. (PMID: 20427577) Barisic M. … Geley S. (Mol. Biol. Cell 2010) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3

Products for SPDL1 Gene

Sources for SPDL1 Gene

Back to Top

Content