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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPDEF Gene

protein-coding   GIFtS: 56
GCID: GC06M034505

SAM Pointed Domain Containing ETS Transcription Factor

(Previous name: SAM pointed domain containing ets transcription factor)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SAM Pointed Domain Containing ETS Transcription Factor1 2     RP11-375E1__A.32
PDEF2 3 5     bA375E1.32
Prostate Epithelium-Specific Ets Transcription Factor2 3     SAM Pointed Domain-Containing Ets Transcription Factor2
Prostate-Derived Ets Factor2 3     PSE3
Prostate-Specific Ets2 3     

External Ids:    HGNC: 172571   Entrez Gene: 258032   Ensembl: ENSG000001246647   OMIM: 6081445   UniProtKB: O952383   

Export aliases for SPDEF gene to outside databases

Previous GC identifers: GC06M034552 GC06M034613 GC06M034228


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SPDEF Gene:
The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the
prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen
(PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian
tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other
cancer-associated molecules, making it a more suitable target for developing specific cancer therapies.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Nov 2011)

GeneCards Summary for SPDEF Gene: 
SPDEF (SAM pointed domain containing ETS transcription factor) is a protein-coding gene. Diseases associated with SPDEF include prostatitis, and prostate cancer, progression of. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ELF3.

UniProtKB/Swiss-Prot: SPDEF_HUMAN, O95238
Function: May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter.
Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer
development. Acts as a transcriptional activator for SERPINB5 promoter

Gene Wiki entry for SPDEF Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPDEF gene promoter:
         Max1   SRF   NF-1   NF-1/L   SRF (504 AA)   NF-kappaB   NF-kappaB2   NF-kappaB1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPDEF promoter sequence
   Search SABiosciences Chromatin IP Primers for SPDEF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPDEF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21.3

SPDEF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPDEF gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M034505:  view genomic region     (about GC identifiers)

Start:
34,505,579 bp from pter      End:
34,524,110 bp from pter
Size:
18,532 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SPDEF_HUMAN, O95238 (See protein sequence)
Recommended Name: SAM pointed domain-containing Ets transcription factor  
Size: 335 amino acids; 37518 Da
Subunit: Interacts with the DNA-binding domain of the androgen receptor. Interacts with NKX3-1
Subcellular location: Nucleus (Probable)
2 PDB 3D structures from and Proteopedia for SPDEF:
1YO5 (3D)        2DKX (3D)    
Secondary accessions: B4DWH8 F5H778
Alternative splicing: 2 isoforms:  O95238-1   O95238-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SPDEF: NX_O95238

Explore proteomics data for SPDEF at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95238

  • SPDEF Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SPDEF Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001239223.1  NP_036523.1  

    ENSEMBL proteins: 
     ENSP00000363149   ENSP00000442715  

    Human Recombinant Protein Products for SPDEF: 
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    Novus Biologicals SPDEF Proteins
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    Cloud-Clone Corp. Proteins for SPDEF 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    SPDEF for ontologies           About GeneDecksing



    SPDEF Antibody Products: 
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    Cloud-Clone Corp. CLIAs for SPDEF


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR003118 Pointed_dom
     IPR013761 SAM/pointed
     IPR000418 Ets_dom

    Graphical View of Domain Structure for InterPro Entry O95238

    ProtoNet protein and cluster: O95238

    1 Blocks protein domain: IPB003118 Sterile alpha motif (SAM)/Pointed domain

    UniProtKB/Swiss-Prot: SPDEF_HUMAN, O95238
    Similarity: Belongs to the ETS family
    Similarity: Contains 1 ETS DNA-binding domain
    Similarity: Contains 1 PNT (pointed) domain


    SPDEF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPDEF_HUMAN, O95238
    Function: May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter.
    Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer
    development. Acts as a transcriptional activator for SERPINB5 promoter

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    SPDEF for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Spdef):
     digestive/alimentary  endocrine/exocrine gland  immune system  mortality/aging  respiratory system 

    SPDEF for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SPDEF: Spdeftm1.2Cle Spdeftm1Shiv Spdeftm1.1Cle

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SPDEF 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SPDEF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPDEF 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPDEF 

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    miRTarBase miRNAs that target SPDEF:
    hsa-mir-510 (MIRT005338), hsa-mir-204 (MIRT005337)

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPDEF


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SPDEF About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of Androgen receptor activity
    Regulation of Androgen receptor activity


    1 BioSystems Pathway for SPDEF
        Regulation of Androgen receptor activity


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SPDEF

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for SPDEF (O952383 ENSP000003631494) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102753, ENSP000003638224I2D: score=2 STRING: ENSP00000363822
    NKX3-1Q998013, ENSP000003702534I2D: score=2 STRING: ENSP00000370253
    PCGF2P352273, ENSP000003540334I2D: score=1 STRING: ENSP00000354033
    EMX1Q047413I2D: score=1 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007275multicellular organismal development TAS10625666
    GO:0010454negative regulation of cell fate commitment IEA--

    SPDEF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SPDEF for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPDEF

    5 Novoseek inferred chemical compound relationships for SPDEF gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    silymarin 52.7 4 15124082 (3)
    dihydrotestosterone 44.7 2 15124082 (2)
    testosterone 32.5 10 10625666 (2), 15124082 (1), 17483333 (1), 18676361 (1)
    estrogen 7.03 2 19505923 (2)
    serine 0 2 15169914 (1), 17491012 (1)

    Search CenterWatch for drugs/clinical trials and news about SPDEF

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SPDEF gene (2 alternative transcripts): 
    NM_001252294.1  NM_012391.2  

    Unigene Cluster for SPDEF:

    SAM pointed domain containing ets transcription factor
    Hs.485158  [show with all ESTs]
    Unigene Representative Sequence: BC021299
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374037(uc003ojq.2 uc011dsq.2) ENST00000544425
    miRNA
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPDEF
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPDEF

    Additional mRNA sequence: 

    AB031549.1 AF071538.1 AK301543.1 BC021299.2 

    9 DOTS entries:

    DT.95345293  DT.215487  DT.121359044  DT.92423798  DT.100009886  DT.95367968  DT.87079326  DT.121358603 
    DT.92423797 

    24/286 AceView cDNA sequences (see all 286):

    BI772270 BF003063 NM_012391 BC021299 AW298436 BQ276248 CD624498 AF071538 
    BM757166 BI770453 CB049255 BG179568 CF121194 AI745526 AB031549 CA489702 
    BU197039 BQ689034 BM798283 BM853102 BE563288 AA639821 AI687669 CD624499 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPDEF expression in normal human tissues (normalized intensities)      SPDEF embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCAGGGAG
    SPDEF Expression
    About this image


    SPDEF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
             brain/midbrain   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Membranous Facial Bones
             skeleton/cranium   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Diencephalic Roof Plate
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Pancreas (Endocrine System)
             visceral organ/gut/foregut-midgut junction   

    See SPDEF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPDEF

    SOURCE GeneReport for Unigene cluster: Hs.485158

    UniProtKB/Swiss-Prot: SPDEF_HUMAN, O95238
    Tissue specificity: Expressed in a very restricted set of primarily hormone-regulated epithelial tissues with
    particularly high expression in the prostate gland. Significantly lower expression is seen in other hormone
    regulated tissues such as mammary gland, salivary gland, and ovary. Expressed in prostate carcinoma cells

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SPDEF gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spdef1 , 5 SAM pointed domain containing ets transcription factor1, 5 82.77(n)1
    88.31(a)1
      17 (14.59 cM)5
    300511  NM_013891.41  NP_038919.11 
     277143525 
    chicken
    (Gallus gallus)
    Aves SPDEF1 SAM pointed domain containing ets transcription factor 79.69(n)
    82.04(a)
      428271  XM_425831.2  XP_425831.2 
    lizard
    (Anolis carolinensis)
    Reptilia SPDEF6
    SAM pointed domain containing ets transcription fa...
    67(a)
    1 ↔ 1
    4(121296072-121340577)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.122372 Transcribed sequence with strong similarity to protein more 82.35(n)    BX708245.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000035431 SAM pointed domain-containing Ets transcription factor-like 62.97(n)
    67.41(a)
      100003543  XM_001343041.1  XP_001343077.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ets98B1 Ets at 98B 56.13(n)
    49.35(a)
      43334  NM_079811.3  NP_524535.2 
    worm
    (Caenorhabditis elegans)
    Secernentea ets-46
    Protein ETS-4, isoform b
    24(a)
    1 ↔ 1
    X(6519107-6522852)


    ENSEMBL Gene Tree for SPDEF (if available)
    TreeFam Gene Tree for SPDEF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPDEF gene
    ELF32  ELF42  ELF12  ELF52  ETV72  EHF2  ELF22  ETV62  
    1 SIMAP similar gene for SPDEF using alignment to 1 protein entry:     SPDEF_HUMAN:
    ELF5

    SPDEF for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/542 SNPs in SPDEF are shown (see all 542)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs9130131,2
    C,A,H--34505121(-) CCGTGC/TGTGAT 2 -- ds500116Minor allele frequency- T:0.01EA NA WA CSA 417
    rs1921407991,2
    --34505125(+) CACACA/GGGGGT 2 -- ds50010--------
    rs1419025221,2
    --34505146(+) CTCACA/GGGAGC 2 -- ds50010--------
    rs77540381,2
    C,F,A,H--34505194(+) AAACAT/GAAACA 2 -- ds500124Minor allele frequency- G:0.13NA NS EA CSA WA 2898
    rs1506319341,2
    --34505246(+) CCTGCA/TCTGCA 2 -- ds50010--------
    rs1396961481,2
    --34505445(+) CCTTGC/TCCTTT 2 -- ds50010--------
    rs1493377171,2
    --34505470(+) GCCACC/TTCCTC 2 -- ds50010--------
    rs1463001321,2
    C--34505585(+) CAGTTC/GTCTAG 2 -- ut310--------
    rs1841861981,2
    --34505618(+) GGGCAC/GTCCTG 2 -- ut310--------
    rs1902389281,2
    --34505767(+) TCTGGA/GAATGC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SPDEF (34505579 - 34524110 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SPDEF:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv516578CNV Loss19592680
    nsv885786CNV Loss21882294
    dgv6833n71CNV Loss21882294
    dgv6832n71CNV Gain21882294
    nsv885792CNV Gain21882294
    dgv6831n71CNV Gain21882294
    dgv1938e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608144    OMIM disorders: --

    8 diseases for SPDEF:    About MalaCards
    prostatitis    prostate cancer, progression of    prostate cancer    breast cancer
    retinoblastoma    colon cancer    retinitis    ovarian cancer


    SPDEF for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for SPDEF gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 53 31 16897429 (6), 17308102 (4), 19505923 (3), 20461080 (2) (see all 11)
    cancer 34.6 5 16897429 (2), 18922924 (1), 15124082 (1)
    prostate cancer 34.5 10 17483333 (4), 10625666 (1), 17521701 (1), 11953821 (1)
    tumors 15.2 44 18567002 (6), 16897429 (6), 17521701 (4), 19505923 (4) (see all 10)
    metastasis 7.58 1 19505923 (1)

    Genetic Association Database (GAD): SPDEF

    Export disorders for SPDEF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPDEF gene, integrated from 9 sources (see all 67):
    (articles sorted by number of sources associating them with SPDEF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression. (PubMed id 10625666)1, 2, 3, 9 Oettgen P.... Libermann T.A. (2000)
    2. NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter. (PubMed id 11809674)1, 2, 9 Chen H.... Bieberich C.J. (2002)
    3. Cloning and expression of the mouse Pse gene encoding a novel Ets family member. (PubMed id 10675039)1, 2, 9 Yamada N.... Nozaki M. (2000)
    4. Analysis of the 2.0 A crystal structure of the protein-DNA complex of the human PDEF Ets domain bound to the prostate specific antigen regulatory site. (PubMed id 15882048)1, 2 Wang Y....Gulick A.M. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    7. Electron micrographs in five minutes. (PubMed id 6857767)1, 3 Johannessen J.V. and Finseth I. (1983)
    8. PDEF is a negative regulator of colon cancer cell gro wth and migration. (PubMed id 19830706)1, 9 Moussa O....Watson D.K. (2009)
    9. Novel role for PDEF in epithelial cell migration and invasion. (PubMed id 16357167)1, 9 Gunawardane R.N....Brugge J.S. (2005)
    10. Expression characteristics of prostate-derived Ets fa ctor support a role in breast and prostate cancer progression. (PubMed id 17521701)1, 9 Sood A.K....Geradts J. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25803 HGNC: 17257 AceView: SPDEF Ensembl:ENSG00000124664 euGenes: HUgn25803
    ECgene: SPDEF H-InvDB: SPDEF

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPDEF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SPDEF Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SPDEF gene:
    Search GeneIP for patents involving SPDEF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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