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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPDEF Gene

protein-coding   GIFtS: 54
GCID: GC06M034505

SAM pointed domain containing ets transcription factor
 Explore 11 diseases affiliated with
SPDEF via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SPDEF    

Aliases
for SPDEF gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
SAM Pointed Domain Containing Ets Transcription Factor1 2     Prostate-Specific Ets2 3
PDEF1 2 3 5     RP11-375E1__A.32
BA375E1.31     SAM Pointed Domain-Containing Ets Transcription Factor2
Prostate Epithelium-Specific Ets Transcription Factor2 3     PSE3
Prostate-Derived Ets Factor2 3     

External Ids:    HGNC: 172571   Entrez Gene: 258032   Ensembl: ENSG000001246647   OMIM: 6081445   UniProtKB: O952383   

Export aliases for SPDEF gene to outside databases

Previous GC identifers: GC06M034552 GC06M034613 GC06M034228


Summaries
for SPDEF gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SPDEF:
The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the
prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA)
promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared
to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules,
making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Nov 2011)

UniProtKB/Swiss-Prot: SPDEF_HUMAN, O95238
Function: May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds
to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer
development. Acts as a transcriptional activator for SERPINB5 promoter

Gene Wiki entry for SPDEF


Genomic Views
for SPDEF gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPDEF gene promoter:
         Max1   SRF   NF-1   NF-1/L   SRF (504 AA)   NF-kappaB   NF-kappaB2   NF-kappaB1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SPDEF promoter sequence
   Search SABiosciences Chromatin IP Primers for SPDEF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPDEF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21.3

SPDEF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPDEF gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M034505:  view genomic region     (about GC identifiers)

Start:
 34,505,579 bp from pter      End:
 34,524,110 bp from pter
Size:
 18,532 bases      Orientation:
 minus strand

Proteins
for SPDEF gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SPDEF_HUMAN, O95238 (See protein sequence)
Recommended Name: SAM pointed domain-containing Ets transcription factor  
Size: 335 amino acids; 37518 Da
Subunit: Interacts with the DNA-binding domain of the androgen receptor. Interacts with NKX3-1
Subcellular location: Nucleus (Probable)
2 PDB 3D structures from and Proteopedia for SPDEF:
1YO5 (3D)        2DKX (3D)    
Secondary accessions: B4DWH8 F5H778
Alternative splicing: 2 isoforms:  O95238-1   O95238-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SPDEF: NX_O95238

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95238

    • SPDEF Protein expression data from MOPED and PaxDb:    About this image 
    SPDEF Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001239223.1  NP_036523.1  

    ENSEMBL proteins: 
     ENSP00000363149   ENSP00000442715  

    Human Recombinant Protein Products for SPDEF: 
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    OriGene Protein Over-expression Lysate: SPDEF
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    Novus Biologicals SPDEF Proteins
    Novus Biologicals SPDEF Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SPDEF

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    SPDEF for ontologies           About GeneDecksing



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    Assay Products for SPDEF: 
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    Uscn ELISAs and CLIAs for SPDEF

    Protein Domains /
    Families
    for SPDEF gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SPDEF for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom
     IPR003118 Pointed_dom
     IPR013761 SAM/pointed
     IPR000418 Ets_dom

    Graphical View of Domain Structure for InterPro Entry O95238

    ProtoNet protein and cluster: O95238

    1 Blocks protein family: IPB003118 Sterile alpha motif (SAM)/Pointed domain

    UniProtKB/Swiss-Prot: SPDEF_HUMAN, O95238
    Similarity: Belongs to the ETS family
    Similarity: Contains 1 ETS DNA-binding domain
    Similarity: Contains 1 PNT (pointed) domain


    Function
    for SPDEF gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPDEF_HUMAN, O95238
    Function: May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds
    to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer
    development. Acts as a transcriptional activator for SERPINB5 promoter

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    SPDEF for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Spdef):
     digestive/alimentary  endocrine/exocrine gland  immune system  mortality/aging  respiratory system 

    SPDEF for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for SPDEF: Spdeftm1.2Cle Spdeftm1Shiv Spdeftm1.1Cle
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SPDEF 

    miRNA
    Products:            		miRTarBase miRNAs that target SPDEF:
    hsa-mir-510 (MIRT005338), hsa-mir-204 (MIRT005337)

    OriGene 3'-UTR Clone: SPDEF
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPDEF
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    SwitchGear 3'UTR luciferase reporter plasmid: SPDEF 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPDEF (see all 7)
    OriGene shRNA RFP: SPDEF
    OriGene siRNA: SPDEF
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    Sirion Biotech Custom design and validation of potent shRNA sequences against SPDEF 

    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPDEF (see all 3)
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    Cell Line
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    Sirion Biotech Customized inducible overexpressing cell line services for SPDEF

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPDEF


    Pathways & Interactions
    for SPDEF gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Regulation of Androgen receptor activity
    		Regulation of Androgen receptor activity1.00


    1 BioSystems Pathway for SPDEF 
        Regulation of Androgen receptor activity


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SPDEF

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for SPDEF (O952383 ENSP000003631494) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102753, ENSP000003638224I2D: score=2 STRING: ENSP00000363822
    NKX3-1Q998013, ENSP000003702534I2D: score=2 STRING: ENSP00000370253
    PCGF2P352273, ENSP000003540334I2D: score=1 STRING: ENSP00000354033
    EMX1Q047413I2D: score=1 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0007275multicellular organismal development TAS10625666
    GO:0008634negative regulation of survival gene product expression ----
    GO:0010454negative regulation of cell fate commitment IEA--

    SPDEF for ontologies           About GeneDecksing



    Drugs & Compounds
    for SPDEF gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SPDEF for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPDEF
    5 Novoseek chemical compound relationships for SPDEF gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    silymarin 52.7 4 15124082 (3)
    dihydrotestosterone 44.7 2 15124082 (2)
    testosterone 32.5 10 10625666 (2), 15124082 (1), 17483333 (1), 18676361 (1)
    estrogen 7.03 2 19505923 (2)
    serine 0 2 15169914 (1), 17491012 (1)

    Search CenterWatch for drugs/clinical trials and news about SPDEF 

    Transcripts
    for SPDEF gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SPDEF gene (2 alternative transcripts): 
    NM_001252294.1  NM_012391.2  

    Unigene Cluster for SPDEF:

    SAM pointed domain containing ets transcription factor
    Hs.485158  [show with all ESTs]
    Unigene Representative Sequence: BC021299
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374037(uc003ojq.2 uc011dsq.2) ENST00000544425

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPDEF
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    SwitchGear 3'UTR luciferase reporter plasmid: SPDEF 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPDEF (see all 7)
    OriGene shRNA RFP: SPDEF
    OriGene siRNA: SPDEF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPDEF
    Sirion Biotech Custom design and validation of potent shRNA sequences against SPDEF 
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPDEF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SPDEF (NM_012391)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPDEF 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPDEF
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPDEF

    Additional cDNA sequence: 

    AB031549.1 AF071538.1 AK301543.1 BC021299.2 

    9 DOTS entries:

    DT.95345293  DT.215487  DT.121359044  DT.92423798  DT.100009886  DT.95367968  DT.87079326  DT.121358603 
    DT.92423797 

    24/286 AceView cDNA sequences (see all 286):

    BM757166 BC021299 NM_012391 CB049255 BQ276248 AF071538 AW298436 BI770453 
    BF003063 BI772270 BG179568 CD624498 BF589055 BE563288 CA489714 BU197039 
    CF121194 AA662521 BM798283 AI687669 AI745526 BU675636 AA639821 CA489702 

    GeneLoc Exon Structure


    Expression
    for SPDEF gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPDEF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGCAGGGAG
    SPDEF Expression
    About this image

    SPDEF expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LungRespiratory BronchiolesMucus-producing CellsLung
    Neural TubeDiencephalic Roof PlateNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SPDEF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPDEF

    SOURCE GeneReport for Unigene cluster: Hs.485158

    UniProtKB/Swiss-Prot: SPDEF_HUMAN, O95238
    Tissue specificity: Expressed in a very restricted set of primarily hormone-regulated epithelial tissues with
    particularly high expression in the prostate gland. Significantly lower expression is seen in other hormone regulated
    tissues such as mammary gland, salivary gland, and ovary. Expressed in prostate carcinoma cells

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    In Situ
    Assay Products:     
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    Orthologs
    for SPDEF gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SPDEF gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SPDEF1 SAM pointed domain containing ets transcription factor 79.69(n)
    82.04(a)    		   428271  XM_425831.2  XP_425831.2 
    lizard
    (Anolis carolinensis)    		 Reptilia SPDEF6
    		 --
    		 73(a)
    		 1 ↔ 1
    		 4(121327684-121337078)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.122372 Transcribed sequence with strong similarity to protein more 82.35(n)    BX708245.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1000035431 SAM pointed domain-containing Ets transcription factor-like 62.97(n)
    67.41(a)    		   100003543  XM_001343041.1  XP_001343077.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Ets98B1 Ets at 98B 56.13(n)
    49.35(a)    		   43334  NM_079811.3  NP_524535.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea ets-46
    		 ETS class transcription factor family member (ets-...
    		 19(a)
    		 1 ↔ 1
    		 X(6519070-6522815)


    ENSEMBL Gene Tree for SPDEF (if available)
    TreeFam Gene Tree for SPDEF (if available) 

    Paralogs
    for SPDEF gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPDEF gene
    ELF32  ELF42  ELF12  ELF52  ETV72  ETV62  ELF22  EHF2  
    1 SIMAP similar gene for SPDEF using alignment to 1 protein entry:     SPDEF_HUMAN:
    ELF5

    SPDEF for paralogs           About GeneDecksing



    Genomic Variants
    for SPDEF gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/425 NCBI SNPs in SPDEF are shown (see all 425)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs9130131,2
    		C,A,H--34505121(-) CCGTGC/TGTGAT 2 -- ds500116Minor allele frequency- T:0.01EA NA WA CSA 417
    rs1921407991,2
    		--34505125(+) CACACA/GGGGGT 2 -- ds50010--------
    rs1419025221,2
    		--34505146(+) CTCACA/GGGAGC 2 -- ds50010--------
    rs77540381,2
    		C,F,A,H--34505194(+) AAACAT/GAAACA 2 -- ds500124Minor allele frequency- G:0.13NA NS EA CSA WA 2898
    rs1506319341,2
    		--34505246(+) CCTGCA/TCTGCA 2 -- ds50010--------
    rs1396961481,2
    		--34505445(+) CCTTGC/TCCTTT 2 -- ds50010--------
    rs1493377171,2
    		--34505470(+) GCCACC/TTCCTC 2 -- ds50010--------
    rs1463001321,2
    		--34505585(+) CAGTTC/GTCTAG 2 -- ut310--------
    rs1841861981,2
    		--34505618(+) GGGCAC/GTCCTG 2 -- ut310--------
    rs1902389281,2
    		--34505767(+) TCTGGA/GAATGC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SPDEF (34505579 - 34524110 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SPDEF
         1 CNV: 3605

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPDEF
    DNA2.0 Custom Variant and Variant Library Synthesis for SPDEF

    Disorders / Diseases
    for SPDEF gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SPDEF for disorders           About GeneDecksing

    OMIM gene information: 608144    OMIM disorders: --

    11 diseases for SPDEF:    About MalaCards
    prostatitis    female breast cancer    prostate cancer    breast cancer
    prostate cancer, progression of    colon cancer    ovarian cancer    retinoblastoma
    prostate carcinoma    retinitis    carcinoma

    5 Novoseek disease relationships for SPDEF gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 53 31 16897429 (6), 17308102 (4), 19505923 (3), 20461080 (2) (see all 11)
    cancer 34.6 5 16897429 (2), 18922924 (1), 15124082 (1)
    prostate cancer 34.5 10 17483333 (4), 10625666 (1), 17521701 (1), 11953821 (1)
    tumors 15.2 44 18567002 (6), 16897429 (6), 17521701 (4), 19505923 (4) (see all 10)
    metastasis 7.58 1 19505923 (1)


    Export disorders for SPDEF gene to outside databases

    Publications
    for SPDEF gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPDEF gene, integrated from 9 sources (see all 62):
    (articles sorted by number of sources associating them with SPDEF)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. PDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression. (PubMed id 10625666)1, 2, 3, 9 Oettgen P.... Libermann T.A. (2000)
    2. NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter. (PubMed id 11809674)1, 2, 9 Chen H.... Bieberich C.J. (2002)
    3. Cloning and expression of the mouse Pse gene encoding a novel Ets family member. (PubMed id 10675039)1, 2, 9 Yamada N.... Nozaki M. (2000)
    4. Analysis of the 2.0 A crystal structure of the protein-DNA complex of the human PDEF Ets domain bound to the prostate specific antigen regulatory site. (PubMed id 15882048)1, 2 Wang Y....Gulick A.M. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    7. Electron micrographs in five minutes. (PubMed id 6857767)1, 3 Johannessen J.V. and Finseth I. (1983)
    8. PDEF is a negative regulator of colon cancer cell gro wth and migration. (PubMed id 19830706)1, 9 Moussa O....Watson D.K. (2009)
    9. Novel role for PDEF in epithelial cell migration and invasion. (PubMed id 16357167)1, 9 Gunawardane R.N....Brugge J.S. (2005)
    10. Expression characteristics of prostate-derived Ets fa ctor support a role in breast and prostate cancer progression. (PubMed id 17521701)1, 9 Sood A.K....Geradts J. (2007)

    External Searches for SPDEF gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing SPDEF gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25803 HGNC: 17257 AceView: SPDEF Ensembl:ENSG00000124664 euGenes: HUgn25803
    ECgene: SPDEF H-InvDB: SPDEF

    Other Databases showing SPDEF gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SPDEF gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPDEF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SPDEF Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SPDEF gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SPDEF gene:
    Search GeneIP for patents involving SPDEF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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