Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SPDEF Gene

protein-coding   GIFtS: 56
GCID: GC06M034505

SAM Pointed Domain Containing ETS Transcription Factor

(Previous name: SAM pointed domain containing ets transcription factor)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
SAM Pointed Domain Containing ETS Transcription Factor1 2     Prostate-Specific Ets2 3
PDEF2 3 5     bA375E1.32
Prostate Epithelium-Specific Ets Transcription Factor2 3     SAM Pointed Domain-Containing Ets Transcription Factor2
Prostate-Derived Ets Factor2 3     PSE3

External Ids:    HGNC: 172571   Entrez Gene: 258032   Ensembl: ENSG000001246647   OMIM: 6081445   UniProtKB: O952383   

Export aliases for SPDEF gene to outside databases

Previous GC identifers: GC06M034552 GC06M034613 GC06M034228


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SPDEF Gene:
The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the
prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen
(PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian
tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other
cancer-associated molecules, making it a more suitable target for developing specific cancer therapies.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Nov 2011)

GeneCards Summary for SPDEF Gene:
SPDEF (SAM pointed domain containing ETS transcription factor) is a protein-coding gene. Diseases associated with SPDEF include prostatitis, and prostate cancer. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ELK4.

UniProtKB/Swiss-Prot: SPDEF_HUMAN, O95238
Function: May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter.
Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer
development. Acts as a transcriptional activator for SERPINB5 promoter

Gene Wiki entry for SPDEF Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPDEF gene promoter:
         Max1   SRF   NF-1   NF-1/L   SRF (504 AA)   NF-kappaB   NF-kappaB2   NF-kappaB1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPDEF promoter sequence
   Search Chromatin IP Primers for SPDEF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPDEF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21.3

SPDEF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPDEF gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M034505:  view genomic region     (about GC identifiers)

Start:
34,505,579 bp from pter      End:
34,524,110 bp from pter
Size:
18,532 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SPDEF_HUMAN, O95238 (See protein sequence)
Recommended Name: SAM pointed domain-containing Ets transcription factor  
Size: 335 amino acids; 37518 Da
Subunit: Interacts with the DNA-binding domain of the androgen receptor. Interacts with NKX3-1
2 PDB 3D structures from and Proteopedia for SPDEF:
1YO5 (3D)        2DKX (3D)    
Secondary accessions: B4DWH8 F5H778
Alternative splicing: 2 isoforms:  O95238-1   O95238-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SPDEF: NX_O95238

Explore proteomics data for SPDEF at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SPDEF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001239223.1  NP_036523.1  

    ENSEMBL proteins: 
     ENSP00000363149   ENSP00000442715  

    SPDEF Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SPDEF
    OriGene Protein Over-expression Lysate for SPDEF
    OriGene MassSpec for SPDEF
    OriGene Custom Protein Services for SPDEF
    GenScript Custom Purified and Recombinant Proteins Services for SPDEF
    Novus Biologicals SPDEF Proteins
    Novus Biologicals SPDEF Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SPDEF

    SPDEF Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SPDEF
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SPDEF
    OriGene Custom Antibody Services for SPDEF
    Novus Biologicals SPDEF Antibodies
    Abcam antibodies for SPDEF
    Cloud-Clone Corp. Antibodies for SPDEF
    Search ThermoFisher Antibodies for SPDEF
    LSBio Antibodies in human, mouse, rat for SPDEF

    SPDEF Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SPDEF
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SPDEF
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SPDEF
    Cloud-Clone Corp. CLIAs for SPDEF


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR003118 Pointed_dom
     IPR013761 SAM/pointed
     IPR000418 Ets_dom

    Graphical View of Domain Structure for InterPro Entry O95238

    ProtoNet protein and cluster: O95238

    1 Blocks protein domain: IPB003118 Sterile alpha motif (SAM)/Pointed domain

    UniProtKB/Swiss-Prot: SPDEF_HUMAN, O95238
    Similarity: Belongs to the ETS family
    Similarity: Contains 1 ETS DNA-binding domain
    Similarity: Contains 1 PNT (pointed) domain


    SPDEF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPDEF_HUMAN, O95238
    Function: May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter.
    Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer
    development. Acts as a transcriptional activator for SERPINB5 promoter

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IBA--
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0043565sequence-specific DNA binding IEA--
         
    SPDEF for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Spdef):
     digestive/alimentary  endocrine/exocrine gland  immune system  mortality/aging  respiratory system 

    SPDEF for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SPDEF: Spdeftm1.2Cle Spdeftm1Shiv Spdeftm1.1Cle

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPDEF
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SPDEF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPDEF
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPDEF

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  ACATCCTGGT 

    miRNA
    Products:
        
    miRTarBase miRNAs that target SPDEF:
    hsa-mir-335-5p (MIRT018698), hsa-mir-510-5p (MIRT005338), hsa-mir-204-5p (MIRT005337)

    Block miRNA regulation of human, mouse, rat SPDEF using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SPDEF
    SwitchGear 3'UTR luciferase reporter plasmidSPDEF 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SPDEF
    Predesigned siRNA for gene silencing in human, mouse, rat SPDEF

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SPDEF

    Clone
    Products:
         
    OriGene clones in human, mouse for SPDEF (see all 6)
    OriGene ORF clones in mouse, rat for SPDEF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SPDEF (NM_012391)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPDEF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPDEF

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SPDEF
    Browse ESI BIO Cell Lines and PureStem Progenitors for SPDEF 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPDEF


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SPDEF_HUMAN, O95238: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IBA--

    SPDEF for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SPDEF About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of Androgen receptor activity
    Regulation of Androgen receptor activity


    1 BioSystems Pathway for SPDEF
        Regulation of Androgen receptor activity


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPDEF
    Interactions:

        GeneGlobe Interaction Network for SPDEF

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for SPDEF (O952383 ENSP000003631494) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102753, ENSP000003638224I2D: score=2 STRING: ENSP00000363822
    NKX3-1Q998013, ENSP000003702534I2D: score=2 STRING: ENSP00000370253
    PCGF2P352273, ENSP000003540334I2D: score=1 STRING: ENSP00000354033
    EMX1Q047413I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA--
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter IBA--
    GO:0007275multicellular organismal development TAS10625666

    SPDEF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPDEF

    5 Novoseek inferred chemical compound relationships for SPDEF gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    silymarin 52.7 4 15124082 (3)
    dihydrotestosterone 44.7 2 15124082 (2)
    testosterone 32.5 10 10625666 (2), 15124082 (1), 17483333 (1), 18676361 (1)
    estrogen 7.03 2 19505923 (2)
    serine 0 2 15169914 (1), 17491012 (1)



    SPDEF for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SPDEF gene (2 alternative transcripts): 
    NM_001252294.1  NM_012391.2  

    Unigene Cluster for SPDEF:

    SAM pointed domain containing ets transcription factor
    Hs.485158  [show with all ESTs]
    Unigene Representative Sequence: BC021299
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374037(uc003ojq.2 uc011dsq.2) ENST00000544425
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SPDEF using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SPDEF
    SwitchGear 3'UTR luciferase reporter plasmidSPDEF 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SPDEF
    Predesigned siRNA for gene silencing in human, mouse, rat SPDEF
    Clone
    Products:
         
    OriGene clones in human, mouse for SPDEF (see all 6)
    OriGene ORF clones in mouse, rat for SPDEF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SPDEF (NM_012391)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPDEF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPDEF
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SPDEF
    OriGene qSTAR qPCR primer pairs in human, mouse for SPDEF
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPDEF
      QuantiTect SYBR Green Assays in human, mouse, rat SPDEF
      QuantiFast Probe-based Assays in human, mouse, rat SPDEF

    Additional mRNA sequence: 

    AB031549.1 AF071538.1 AK301543.1 BC021299.2 

    9 DOTS entries:

    DT.95345293  DT.215487  DT.121359044  DT.92423798  DT.100009886  DT.95367968  DT.87079326  DT.121358603 
    DT.92423797 

    Selected AceView cDNA sequences (see all 286):

    BM757166 BF003063 BQ276248 BG179568 CD624498 AW298436 BI770453 AF071538 
    CB049255 NM_012391 BC021299 BI772270 AB031549 BQ689034 BM006343 BU197039 
    AI687669 CD624499 AI979170 BU675636 BM798283 CF146817 CA489714 BF589055 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SPDEF expression in normal human tissues (normalized intensities)      SPDEF embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCAGGGAG
    SPDEF Expression
    About this image


    SPDEF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Diencephalic Roof Plate
     
     Epithelial Cells
             Mucus-producing Cells Respiratory Bronchioles
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
     
     Lung (Respiratory System)
             Mucus-producing Cells Respiratory Bronchioles
     
     Brain (Nervous System)
             Cerebral Cortex
    SPDEF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPDEF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.485158

    UniProtKB/Swiss-Prot: SPDEF_HUMAN, O95238
    Tissue specificity: Expressed in a very restricted set of primarily hormone-regulated epithelial tissues with
    particularly high expression in the prostate gland. Significantly lower expression is seen in other hormone
    regulated tissues such as mammary gland, salivary gland, and ovary. Expressed in prostate carcinoma cells

        Custom PCR Arrays for SPDEF
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SPDEF
    OriGene qSTAR qPCR primer pairs in human, mouse for SPDEF
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPDEF
    QuantiTect SYBR Green Assays in human, mouse, rat SPDEF
    QuantiFast Probe-based Assays in human, mouse, rat SPDEF
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPDEF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for SPDEF gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spdef1 , 5 SAM pointed domain containing ets transcription factor1, 5 82.77(n)1
    88.31(a)1
      17 (14.59 cM)5
    300511  NM_013891.41  NP_038919.11 
     277143525 
    chicken
    (Gallus gallus)
    Aves SPDEF1 SAM pointed domain containing ets transcription factor 76.87(n)
    78.83(a)
      428271  XM_425831.3  XP_425831.3 
    lizard
    (Anolis carolinensis)
    Reptilia SPDEF6
    SAM pointed domain containing ETS transcription fa...
    68(a)
    1 ↔ 1
    4(121296072-121340577)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.122372 Transcribed sequence with strong similarity to protein more 82.35(n)    BX708245.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000035431 SAM pointed domain-containing Ets transcription factor-like 68.76(n)
    75.65(a)
      100003543  XM_001343041.2  XP_001343077.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ets98B6
    Ets at 98B
    29(a)
    1 ↔ 1
    3R(23562262-23574089)


    ENSEMBL Gene Tree for SPDEF (if available)
    TreeFam Gene Tree for SPDEF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SPDEF gene
    ELK42  ELF32  ELF42  ELF12  ELF52  ETV72  ELK12  ETV62  
    EHF2  ELF22  ELK32  
    1 SIMAP similar gene for SPDEF using alignment to 1 protein entry:     SPDEF_HUMAN:
    ELF5

    SPDEF for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SPDEF (see all 542)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs9130131,2
    C,A,H--34505121(-) CCGTGC/TGTGAT 2 -- ds500116Minor allele frequency- T:0.01EA NA WA CSA 417
    rs1921407991,2
    --34505125(+) CACACA/GGGGGT 2 -- ds50010--------
    rs1419025221,2
    --34505146(+) CTCACA/GGGAGC 2 -- ds50010--------
    rs77540381,2
    C,F,A,H--34505194(+) AAACAT/GAAACA 2 -- ds500124Minor allele frequency- G:0.13NA NS EA CSA WA 2898
    rs1506319341,2
    --34505246(+) CCTGCA/TCTGCA 2 -- ds50010--------
    rs1396961481,2
    --34505445(+) CCTTGC/TCCTTT 2 -- ds50010--------
    rs1493377171,2
    --34505470(+) GCCACC/TTCCTC 2 -- ds50010--------
    rs1463001321,2
    C--34505585(+) CAGTTC/GTCTAG 2 -- ut310--------
    rs1841861981,2
    --34505618(+) GGGCAC/GTCCTG 2 -- ut310--------
    rs1902389281,2
    --34505767(+) TCTGGA/GAATGC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SPDEF (34505579 - 34524110 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SPDEF:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv516578CNV Loss19592680
    nsv885786CNV Loss21882294
    dgv6833n71CNV Loss21882294
    dgv6832n71CNV Gain21882294
    nsv885792CNV Gain21882294
    dgv6831n71CNV Gain21882294
    dgv1938e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SPDEF
    DNA2.0 Custom Variant and Variant Library Synthesis for SPDEF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608144    OMIM disorders: --

    8 diseases for SPDEF:    About MalaCards
    prostatitis    prostate cancer    bronchiolitis    retinoblastoma
    breast cancer    retinitis    ovarian cancer    cerebritis


    SPDEF for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for SPDEF gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 53 31 16897429 (6), 17308102 (4), 19505923 (3), 20461080 (2) (see all 11)
    cancer 34.6 5 16897429 (2), 18922924 (1), 15124082 (1)
    prostate cancer 34.5 10 17483333 (4), 10625666 (1), 17521701 (1), 11953821 (1)
    tumors 15.2 44 18567002 (6), 16897429 (6), 17521701 (4), 19505923 (4) (see all 10)
    metastasis 7.58 1 19505923 (1)

    Genetic Association Database (GAD): SPDEF

    Export disorders for SPDEF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SPDEF gene, integrated from 10 sources (see all 71):
    (articles sorted by number of sources associating them with SPDEF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression. (PubMed id 10625666)1, 2, 3, 9 Oettgen P.... Libermann T.A. (J. Biol. Chem. 2000)
    2. NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter. (PubMed id 11809674)1, 2, 9 Chen H.... Bieberich C.J. (Cancer Res. 2002)
    3. Cloning and expression of the mouse Pse gene encoding a novel Ets family member. (PubMed id 10675039)1, 2, 9 Yamada N.... Nozaki M. (Gene 2000)
    4. Analysis of the 2.0 A crystal structure of the protein-DNA complex of the human PDEF Ets domain bound to the prostate specific antigen regulatory site. (PubMed id 15882048)1, 2 Wang Y....Gulick A.M. (Biochemistry 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    7. Electron micrographs in five minutes. (PubMed id 6857767)1, 3 Johannessen J.V. and Finseth I. (Ultrastruct Pathol 1983)
    8. PDEF is a negative regulator of colon cancer cell growth and migration. (PubMed id 19830706)1, 9 Moussa O....Watson D.K. (J. Cell. Biochem. 2009)
    9. Novel role for PDEF in epithelial cell migration and invasion. (PubMed id 16357167)1, 9 Gunawardane R.N....Brugge J.S. (Cancer Res. 2005)
    10. Expression characteristics of prostate-derived Ets factor support a role in breast and prostate cancer progression. (PubMed id 17521701)1, 9 Sood A.K....Geradts J. (Hum. Pathol. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 25803 HGNC: 17257 AceView: SPDEF Ensembl:ENSG00000124664 euGenes: HUgn25803
    ECgene: SPDEF H-InvDB: SPDEF

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SPDEF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SPDEF Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SPDEF gene:
    Search GeneIP for patents involving SPDEF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of SPDEF
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SPDEF   OriGene RNAi products in human, mouse, rat for SPDEF  
     OriGene qPCR primer pairs and template standards for SPDEF   OriGene Protein Over-expression Lysate for SPDEF  
     OriGene MassSpec something-or-other for SPDEF   OriGene clones in human, mouse for SPDEF  
     OriGene qSTAR qPCR primer pairs in human, mouse for SPDEF   OriGene Purified Protein for SPDEF  
     OriGene ORF clones in mouse, rat for SPDEF   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SPDEF   OriGene Custom Protein Services for SPDEF  

     
     
     Block miRNA regulation of human, mouse, rat SPDEF using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SPDEF
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPDEF Predesigned siRNA for gene silencing in human, mouse, rat SPDEF
     QuantiFast Probe-based Assays in human, mouse, rat SPDEF QuantiTect SYBR Green Assays in human, mouse, rat SPDEF
     Custom PCR Arrays for SPDEF Search Chromatin IP Primers for SPDEF
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPDEF  GeneGlobe Interaction Network for SPDEF
     Regulatory tfbs in SPDEF promoter
     GenScript Custom Purified and Recombinant Proteins Services for SPDEF GenScript cDNA clones with any tag delivered in your preferred vector for SPDEF
     GenScript Custom Assay Services for SPDEF GenScript Custom overexpressing Cell Line Services for SPDEF
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SPDEF
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SPDEF antibodies
     SPDEF proteins
     SPDEF lysates
     Antibodies for SPDEF
     See all of Abcam's Antibodies, Kits and Proteins for SPDEF
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SPDEF
     Antibodies for SPDEF
     ELISAs for SPDEF
     CLIAs for SPDEF



     Browse ESI BIO Cell Lines and PureStem Progenitors for SPDEF
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPDEF
     SwitchGear 3'UTR luciferase reporter plasmids for SPDEF
     SwitchGear Promoter luciferase reporter plasmids for SPDEF
     Search ThermoFisher Antibodies for SPDEF
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPDEF
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPDEF
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SPDEF
     LSBio Antibodies in human, mouse, rat for SPDEF
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SPDEF gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4