Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SPDEF Gene

Aliases for SPDEF Gene

  • SAM Pointed Domain Containing ETS Transcription Factor 2 3
  • PDEF 3 4 6
  • Prostate Epithelium-Specific Ets Transcription Factor 3 4
  • Prostate-Derived Ets Factor 3 4
  • Prostate-Specific Ets 3 4
  • SAM Pointed Domain-Containing Ets Transcription Factor 3
  • BA375E1.3 3
  • PSE 4

External Ids for SPDEF Gene

Summaries for SPDEF Gene

Entrez Gene Summary for SPDEF Gene

  • The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for SPDEF Gene

SPDEF (SAM Pointed Domain Containing ETS Transcription Factor) is a Protein Coding gene. Diseases associated with SPDEF include prostate cancer. Among its related pathways are Regulation of Androgen receptor activity. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is ELF4.

UniProtKB/Swiss-Prot for SPDEF Gene

  • May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5-GGAT-3 DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter.

Gene Wiki entry for SPDEF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPDEF Gene

Genomics for SPDEF Gene

Genomic Location for SPDEF Gene

Start:
34,537,802 bp from pter
End:
34,556,333 bp from pter
Size:
18,532 bases
Orientation:
Minus strand

Genomic View for SPDEF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPDEF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPDEF Gene

Regulatory Elements for SPDEF Gene

Proteins for SPDEF Gene

  • Protein details for SPDEF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95238-SPDEF_HUMAN
    Recommended name:
    SAM pointed domain-containing Ets transcription factor
    Protein Accession:
    O95238
    Secondary Accessions:
    • B4DWH8
    • F5H778

    Protein attributes for SPDEF Gene

    Size:
    335 amino acids
    Molecular mass:
    37518 Da
    Quaternary structure:
    • Interacts with the DNA-binding domain of the androgen receptor. Interacts with NKX3-1.

    Three dimensional structures from OCA and Proteopedia for SPDEF Gene

    Alternative splice isoforms for SPDEF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPDEF Gene

Proteomics data for SPDEF Gene at MOPED

Post-translational modifications for SPDEF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPDEF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPDEF Gene

Domains for SPDEF Gene

Protein Domains for SPDEF Gene

UniProtKB/Swiss-Prot:

SPDEF_HUMAN
Domain:
  • Contains 1 ETS DNA-binding domain.:
    • O95238
  • Contains 1 PNT (pointed) domain.:
    • O95238
Family:
  • Belongs to the ETS family.:
    • O95238
genes like me logo Genes that share domains with SPDEF: view

No data available for Gene Families for SPDEF Gene

Function for SPDEF Gene

Molecular function for SPDEF Gene

UniProtKB/Swiss-Prot Function: May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5-GGAT-3 DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter.

Gene Ontology (GO) - Molecular Function for SPDEF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with SPDEF: view
genes like me logo Genes that share phenotypes with SPDEF: view

Animal Models for SPDEF Gene

MGI Knock Outs for SPDEF:

miRNA for SPDEF Gene

miRTarBase miRNAs that target SPDEF
Targeting motifs for SPDEF Gene
HOMER Transcription Factor Regulatory Elements motif SPDEF
  • Consensus sequence: ACATCCTGGT Submotif: canonical Cell Type: VCaP GeoId: SRA014231

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for SPDEF Gene

Localization for SPDEF Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPDEF Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPDEF Gene COMPARTMENTS Subcellular localization image for SPDEF gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for SPDEF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with SPDEF: view

Pathways for SPDEF Gene

genes like me logo Genes that share pathways with SPDEF: view

Pathways by source for SPDEF Gene

1 BioSystems pathway for SPDEF Gene

Gene Ontology (GO) - Biological Process for SPDEF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 21656828
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter IBA --
GO:0007275 multicellular organismal development TAS 10625666
GO:0010454 negative regulation of cell fate commitment IEA --
genes like me logo Genes that share ontologies with SPDEF: view

Compounds for SPDEF Gene

(5) Novoseek inferred chemical compound relationships for SPDEF Gene

Compound -log(P) Hits PubMed IDs
silymarin 52.7 3
dihydrotestosterone 44.7 2
testosterone 32.5 5
estrogen 7.03 2
serine 0 2
genes like me logo Genes that share compounds with SPDEF: view

Transcripts for SPDEF Gene

Unigene Clusters for SPDEF Gene

SAM pointed domain containing ets transcription factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPDEF Gene

No ASD Table

Relevant External Links for SPDEF Gene

GeneLoc Exon Structure for
SPDEF
ECgene alternative splicing isoforms for
SPDEF

Expression for SPDEF Gene

mRNA expression in normal human tissues for SPDEF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPDEF Gene

This gene is overexpressed in Prostate (17.7), Minor Salivary Gland (11.5), Breast - Mammary Tissue (4.6), Stomach (4.5), and Colon - Transverse (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPDEF Gene

SOURCE GeneReport for Unigene cluster for SPDEF Gene Hs.485158

mRNA Expression by UniProt/SwissProt for SPDEF Gene

O95238-SPDEF_HUMAN
Tissue specificity: Expressed in a very restricted set of primarily hormone-regulated epithelial tissues with particularly high expression in the prostate gland. Significantly lower expression is seen in other hormone regulated tissues such as mammary gland, salivary gland, and ovary. Expressed in prostate carcinoma cells.
genes like me logo Genes that share expressions with SPDEF: view

Orthologs for SPDEF Gene

This gene was present in the common ancestor of animals.

Orthologs for SPDEF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPDEF 36
  • 99.4 (n)
  • 98.81 (a)
SPDEF 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPDEF 36
  • 89.85 (n)
  • 92.24 (a)
SPDEF 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPDEF 36
  • 91.24 (n)
  • 94.03 (a)
SPDEF 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spdef 36
  • 82.77 (n)
  • 88.31 (a)
Spdef 16
Spdef 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPDEF 37
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPDEF 37
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spdef 36
  • 84.21 (n)
  • 89.54 (a)
chicken
(Gallus gallus)
Aves SPDEF 36
  • 76.87 (n)
  • 78.83 (a)
SPDEF 37
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPDEF 37
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spdef 36
  • 65.71 (n)
  • 72.2 (a)
Str.12237 36
zebrafish
(Danio rerio)
Actinopterygii LOC100003543 36
  • 68.76 (n)
  • 75.65 (a)
SPDEF 37
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ets98B 37
  • 29 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 15 (a)
OneToOne
Species with no ortholog for SPDEF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPDEF Gene

ENSEMBL:
Gene Tree for SPDEF (if available)
TreeFam:
Gene Tree for SPDEF (if available)

Paralogs for SPDEF Gene

Paralogs for SPDEF Gene

Selected SIMAP similar genes for SPDEF Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPDEF: view

Variants for SPDEF Gene

Sequence variations from dbSNP and Humsavar for SPDEF Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs8171 -- 34,537,963(-) GGCAG(C/T)GACTC utr-variant-3-prime
rs15482 -- 34,537,842(-) CCAGG(A/G)GTGCC utr-variant-3-prime
rs15483 -- 34,537,852(-) AGTTG(A/G)GCAGC utr-variant-3-prime
rs707965 -- 34,537,901(+) GTGCA(A/G)AATGG utr-variant-3-prime
rs913013 -- 34,537,344(-) CCGTG(C/T)GTGAT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SPDEF Gene

Variant ID Type Subtype PubMed ID
dgv1938e1 CNV Complex 17122850
dgv6831n71 CNV Gain 21882294
nsv885786 CNV Loss 21882294
dgv6832n71 CNV Gain 21882294
dgv6833n71 CNV Loss 21882294
nsv516578 CNV Loss 19592680
nsv885792 CNV Gain 21882294

Relevant External Links for SPDEF Gene

HapMap Linkage Disequilibrium report
SPDEF

Disorders for SPDEF Gene

(1) MalaCards Diseases for SPDEF Gene

Search for SPDEF Gene in MalaCards »

(5) Novoseek inferred disease relationships for SPDEF Gene

Disease -log(P) Hits PubMed IDs
breast cancer 53 23
cancer 34.6 4
prostate cancer 34.5 7
tumors 15.2 30
metastasis 7.58 1

Relevant External Links for SPDEF

Genetic Association Database (GAD)
SPDEF
genes like me logo Genes that share disorders with SPDEF: view

No data available for UniProtKB/Swiss-Prot for SPDEF Gene

Publications for SPDEF Gene

  1. PDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression. (PMID: 10625666) Oettgen P. … Libermann T.A. (J. Biol. Chem. 2000) 2 3 4 23
  2. NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter. (PMID: 11809674) Chen H. … Bieberich C.J. (Cancer Res. 2002) 3 4 23
  3. Cloning and expression of the mouse Pse gene encoding a novel Ets family member. (PMID: 10675039) Yamada N. … Nozaki M. (Gene 2000) 3 4 23
  4. A small subgroup of operable breast cancer patients with poor prognosis identified by quantitative real-time RT-PCR detection of mammaglobin A and trefoil factor 1 mRNA expression in bone marrow. (PMID: 18846421) Tjensvoll K. … NordgAYrd O. (Breast Cancer Res. Treat. 2009) 3 23
  5. SAM pointed domain ETS factor (SPDEF) regulates terminal differentiation and maturation of intestinal goblet cells. (PMID: 19786015) Noah T.K. … Shroyer N.F. (Exp. Cell Res. 2010) 3 23

Products for SPDEF Gene

Sources for SPDEF Gene

Back to Top

Content