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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPCS3 Gene

protein-coding   GIFtS: 49
GCID: GC04P177241

Signal Peptidase Complex Subunit 3 Homolog (S. Cerevisiae)

  Search for SPCS3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Signal Peptidase Complex Subunit 3 Homolog (S. Cerevisiae)1 2     YLR066W2
Microsomal Signal Peptidase 22/23 KDa Subunit2 3     Microsomal Signal Peptidase 23 KDa Subunit2
SPC22/232 3     Signal Peptidase Complex Subunit 32
SPase 22/23 KDa Subunit2 3     SPase 22 KDa Subunit2
PRO35672     EC 3.4.-.-3
SPC32     SPC223

External Ids:    HGNC: 262121   Entrez Gene: 605592   Ensembl: ENSG000001291287   UniProtKB: P610093   

Export aliases for SPCS3 gene to outside databases

Previous GC identifers: GC04P177617 GC04P177478 GC04P172992


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SPCS3 Gene: 
SPCS3 (signal peptidase complex subunit 3 homolog (S. cerevisiae)) is a protein-coding gene. Among its related super-pathways are Incretin Synthesis, Secretion, and Inactivation and Viral mRNA Translation. GO annotations related to this gene include peptidase activity.

UniProtKB/Swiss-Prot: SPCS3_HUMAN, P61009
Function: Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins
as they are translocated into the lumen of the endoplasmic reticulum (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPCS3 gene promoter:
         LHX3b/Lhx3b   Pbx1a   MEF-2   Meis-1b   MEF-2A   S8   LHX3a/Lhx3a   Meis-1a   aMEF-2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPCS3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SPCS3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPCS3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q34.2   Ensembl cytogenetic band:  4q34.2   HGNC cytogenetic band: 4q34.2

SPCS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPCS3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P177241:  view genomic region     (about GC identifiers)

Start:
177,241,090 bp from pter      End:
177,253,396 bp from pter
Size:
12,307 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SPCS3_HUMAN, P61009 (See protein sequence)
Recommended Name: Signal peptidase complex subunit 3  
Size: 180 amino acids; 20313 Da
Subunit: Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C,
SPCS1, SPCS2 and SPCS3 (By similarity)
Subcellular location: Microsome membrane; Single-pass type II membrane protein (By similarity). Endoplasmic
reticulum membrane; Single-pass type II membrane protein (By similarity)
Secondary accessions: P12280 Q9H0S7

Explore the universe of human proteins at neXtProt for SPCS3: NX_P61009

Explore proteomics data for SPCS3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P61009

  • SPCS3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SPCS3 Protein Expression
    REFSEQ proteins: NP_068747.1  
    ENSEMBL proteins: 
     ENSP00000427463  
    Reactome Protein details: P61009
    Human Recombinant Protein Products for SPCS3: 
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    Novus Biologicals SPCS3 Proteins
    Novus Biologicals SPCS3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SPCS3 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA--
    GO:0005787signal peptidase complex IEA--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral to membrane IEA--

    SPCS3 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for SPCS3 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR007653 SPC22

    Graphical View of Domain Structure for InterPro Entry P61009

    ProtoNet protein and cluster: P61009

    1 Blocks protein domain: IPB007653 Signal peptidase subunit

    UniProtKB/Swiss-Prot: SPCS3_HUMAN, P61009
    Similarity: Belongs to the SPCS3 family


    SPCS3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPCS3_HUMAN, P61009
    Function: Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins
    as they are translocated into the lumen of the endoplasmic reticulum (By similarity)

         Enzyme Number (IUBMB): EC 3.4.-.-1

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008233peptidase activity IEA--
         
    SPCS3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SPCS3:
     Decreased Tat-dependent transc 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SPCS3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SPCS3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPCS3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPCS3 

    miRNA
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    miRTarBase miRNAs that target SPCS3:
    hsa-let-7b (MIRT001589)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPCS3
    8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate SPCS3 (see all 62):
    hsa-miR-142-5p hsa-miR-607 hsa-let-7d hsa-miR-139-5p hsa-miR-16-1* hsa-miR-3653 hsa-miR-30d hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidSPCS3 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPCS3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SPCS3 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
    Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)0.89
    Incretin Synthesis, Secretion, and Inactivation0.89
    Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)0.89
    Synthesis, Secretion, and Deacylation of Ghrelin0.46
    2Viral mRNA Translation
    Translation0.78
    SRP-dependent cotranslational protein targeting to membrane0.77
    3Generic Transcription Pathway
    Gene Expression0.47
    4Insulin Processing
    Peptide hormone metabolism0.39
    5Asparagine N-linked glycosylation
    Metabolism of proteins0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/9        Reactome Pathways for SPCS3 (see all 9)
        Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
    Incretin Synthesis, Secretion, and Inactivation
    Translation
    SRP-dependent cotranslational protein targeting to membrane
    Synthesis, Secretion, and Deacylation of Ghrelin


    1         Kegg Pathway  (Kegg details for SPCS3):
        Protein export


    SPCS3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPCS3

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation TAS--
    GO:0006465signal peptide processing IEA--
    GO:0006508proteolysis IEA--
    GO:0006614SRP-dependent cotranslational protein targeting to membrane TAS--
    GO:0010467gene expression TAS--

    SPCS3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPCS3

    Search CenterWatch for drugs/clinical trials and news about SPCS3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SPCS3 gene: 
    NM_021928.3  

    Unigene Cluster for SPCS3:

    Signal peptidase complex subunit 3 homolog (S. cerevisiae)
    Hs.42194  [show with all ESTs]
    Unigene Representative Sequence: NM_021928
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000503362(uc003iur.4) ENST00000507678 ENST00000513139 ENST00000507001

    miRNA
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    8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate SPCS3 (see all 62):
    hsa-miR-142-5p hsa-miR-607 hsa-let-7d hsa-miR-139-5p hsa-miR-16-1* hsa-miR-3653 hsa-miR-30d hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidSPCS3 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: SPCS3 (NM_021928)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPCS3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPCS3
    Sirion Biotech Customized lentivirus for stable overexpression of SPCS3 
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    Primer
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    OriGene qPCR primer pairs and template standards for SPCS3
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPCS3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPCS3

    Additional mRNA sequence: 

    AK026302.1 AL136660.1 AY359044.1 BC047290.1 

    12 DOTS entries:

    DT.113788  DT.91963153  DT.97844495  DT.99949409  DT.40295589  DT.75126785  DT.95275395  DT.121256623 
    DT.95165450  DT.97844496  DT.97844498  DT.86854163 

    24/238 AceView cDNA sequences (see all 238):

    W93981 AI016013 AK026302 CR603061 BM023480 AA766881 AA101804 N47834 
    AA663063 BC043490 CF529375 BF002291 BQ012244 AI693991 BG164870 BX494036 
    NM_021928 BU633751 AA101782 AW001835 AA954542 AA411686 AW873817 AI077414 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPCS3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAATACTGA
    SPCS3 Expression
    About this image


    See SPCS3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPCS3

    SOURCE GeneReport for Unigene cluster: Hs.42194
        SABiosciences Custom PCR Arrays for SPCS3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPCS3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SPCS3 gene from 10/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spcs31 , 5 signal peptidase complex subunit 3 homolog (S. cerevisiae)1, 5 93.33(n)1
    100(a)1
      8 (29.26 cM)5
    766871  NM_029701.11  NP_083977.11 
     545204335 
    chicken
    (Gallus gallus)
    Aves SPCS31 signal peptidase complex subunit 3 homolog (S. cerevisiae) 85.56(n)
    90(a)
      396234  NM_205297.1  NP_990628.1 
    lizard
    (Anolis carolinensis)
    Reptilia SPCS36
    Uncharacterized protein
    89(a)
    1 ↔ 1
    5(117373798-117390991)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.257762 Xenopus laevis transcribed sequence with moderate similarity more 80.14(n)    CA789769.1 
    zebrafish
    (Danio rerio)
    Actinopterygii spcs31 signal peptidase complex subunit 3 homolog (S. cerevisiae) 76.11(n)
    82.78(a)
      405884  NM_212948.1  NP_998113.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Spase22-231 Spase 22/23-subunit 56.32(n)
    57.47(a)
      42885  NM_142977.4  NP_651234.1 
    worm
    (Caenorhabditis elegans)
    Secernentea K12H4.41 Protein K12H4.4 55.81(n)
    48.88(a)
      176133  NM_066354.3  NP_498755.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SPC36
    Subunit of signal peptidase complex (Spc1p, Spc2p,...
    23(a)
    1 ↔ 1
    XII(267169-267723)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G052301 Signal peptidase complex subunit 3A 51.35(n)
    39.19(a)
      819687  NM_111396.3  NP_566250.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g01318001 hypothetical protein 50.56(n)
    40.83(a)
      4325792  NM_001048462.2  NP_001041927.1 


    ENSEMBL Gene Tree for SPCS3 (if available)
    TreeFam Gene Tree for SPCS3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPCS3 gene

    SPCS3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SPCS3
    PGOHUM00000244456


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/324 SNPs in SPCS3 are shown (see all 324)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38067641,2
    H--177239183(+) TCATTT/CGAGTG 1 -- us2k14Minor allele frequency- C:0.00NS EA 418
    rs1876297421,2
    --177239265(+) GTTTGC/TTTCCG 1 -- us2k10--------
    rs14541621,2
    C,F,O,A,H--177239269(-) ATTTCG/AGAAAC 1 -- us2k132Minor allele frequency- A:0.10NA NS EA WA 3140
    rs14541611,2
    C,F,H--177239305(-) AGTGAA/C/TGGACC 1 -- us2k113NS EA NA WA 1548
    rs176809431,2
    C,F,H--177239322(+) CCACAT/CATAAC 1 -- us2k126Minor allele frequency- C:0.04NA NS EA 2826
    rs14541601,2
    C,F,A,H--177239338(-) AGGCAA/GCCATT 1 -- us2k1 tfbs322Minor allele frequency- G:0.09NS EA NA WA 2400
    rs1916687311,2
    --177239341(+) GGTTGA/CCTGTG 1 -- us2k10--------
    rs1842630361,2
    --177239384(+) ATATAA/GAGTCA 1 -- us2k10--------
    rs1872886011,2
    --177239391(+) GTCAAA/CTTCTT 1 -- us2k10--------
    rs1921052401,2
    C--177239605(+) TGTTGG/TCCCAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SPCS3 (177241090 - 177253396 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SPCS3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2728772CNV Deletion23290073
    esv34137CNV Loss18971310

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SPCS3
    DNA2.0 Custom Variant and Variant Library Synthesis for SPCS3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SPCS3 for disorders           About MalaCards

    SPCS3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SPCS3
    Human Genome Epidemiology (HuGE) Navigator: SPCS3 (1 document)

    Export disorders for SPCS3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SPCS3 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with SPCS3)
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    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    6. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PubMed id 22174851)4 Lingappa J.R....Goldstein D. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 60559 HGNC: 26212 AceView: FLJ22649 Ensembl:ENSG00000129128 euGenes: HUgn60559
    ECgene: SPCS3 Kegg: 60559 H-InvDB: SPCS3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPCS3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SPCS3 gene:
    Search GeneIP for patents involving SPCS3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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