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Aliases for SPCS3 Gene

Aliases for SPCS3 Gene

  • Signal Peptidase Complex Subunit 3 Homolog (S. Cerevisiae) 2 3
  • Microsomal Signal Peptidase 22/23 KDa Subunit 3 4
  • SPase 22/23 KDa Subunit 3 4
  • SPC22/23 3 4
  • Microsomal Signal Peptidase 23 KDa Subunit 3
  • Signal Peptidase Complex Subunit 3 3
  • SPase 22 KDa Subunit 3
  • EC 3.4.-.- 4
  • PRO3567 3
  • YLR066W 3
  • SPC22 4
  • SPC3 3

External Ids for SPCS3 Gene

Previous GeneCards Identifiers for SPCS3 Gene

  • GC04P177617
  • GC04P177478
  • GC04P177241
  • GC04P172992

Summaries for SPCS3 Gene

GeneCards Summary for SPCS3 Gene

SPCS3 (Signal Peptidase Complex Subunit 3 Homolog (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Gene Expression. GO annotations related to this gene include peptidase activity.

UniProtKB/Swiss-Prot for SPCS3 Gene

  • Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPCS3 Gene

Genomics for SPCS3 Gene

Regulatory Elements for SPCS3 Gene

Genomic Location for SPCS3 Gene

Start:
176,319,939 bp from pter
End:
176,332,245 bp from pter
Size:
12,307 bases
Orientation:
Plus strand

Genomic View for SPCS3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPCS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPCS3 Gene

Proteins for SPCS3 Gene

  • Protein details for SPCS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61009-SPCS3_HUMAN
    Recommended name:
    Signal peptidase complex subunit 3
    Protein Accession:
    P61009
    Secondary Accessions:
    • P12280
    • Q9H0S7

    Protein attributes for SPCS3 Gene

    Size:
    180 amino acids
    Molecular mass:
    20313 Da
    Quaternary structure:
    • Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3.

neXtProt entry for SPCS3 Gene

Proteomics data for SPCS3 Gene at MOPED

Post-translational modifications for SPCS3 Gene

  • Ubiquitination at Lys49, Lys117, and Lys137
  • Glycosylation at Asn141
  • Modification sites at PhosphoSitePlus

Other Protein References for SPCS3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SPCS3 Gene

Domains for SPCS3 Gene

Protein Domains for SPCS3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SPCS3 Gene

Graphical View of Domain Structure for InterPro Entry

P61009

UniProtKB/Swiss-Prot:

SPCS3_HUMAN :
  • P61009
Family:
  • Belongs to the SPCS3 family.
genes like me logo Genes that share domains with SPCS3: view

No data available for Gene Families for SPCS3 Gene

Function for SPCS3 Gene

Molecular function for SPCS3 Gene

UniProtKB/Swiss-Prot Function: Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.

Enzyme Numbers (IUBMB) for SPCS3 Gene

Gene Ontology (GO) - Molecular Function for SPCS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA --
genes like me logo Genes that share ontologies with SPCS3: view

Phenotypes for SPCS3 Gene

GenomeRNAi human phenotypes for SPCS3:
genes like me logo Genes that share phenotypes with SPCS3: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPCS3

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for SPCS3 Gene

Localization for SPCS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPCS3 Gene

Microsome membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPCS3 Gene COMPARTMENTS Subcellular localization image for SPCS3 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SPCS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0005787 signal peptidase complex IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SPCS3: view

Pathways for SPCS3 Gene

genes like me logo Genes that share pathways with SPCS3: view

Pathways by source for SPCS3 Gene

Interacting Proteins for SPCS3 Gene

Gene Ontology (GO) - Biological Process for SPCS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS --
GO:0006465 signal peptide processing IEA --
GO:0006508 proteolysis --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with SPCS3: view

Transcripts for SPCS3 Gene

mRNA/cDNA for SPCS3 Gene

Unigene Clusters for SPCS3 Gene

Signal peptidase complex subunit 3 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPCS3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPCS3 Gene

No ASD Table

Relevant External Links for SPCS3 Gene

GeneLoc Exon Structure for
SPCS3
ECgene alternative splicing isoforms for
SPCS3

Expression for SPCS3 Gene

mRNA expression in normal human tissues for SPCS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPCS3 Gene

SOURCE GeneReport for Unigene cluster for SPCS3 Gene Hs.42194

genes like me logo Genes that share expressions with SPCS3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SPCS3 Gene

Orthologs for SPCS3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SPCS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPCS3 35
  • 99.44 (n)
  • 99.44 (a)
SPCS3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPCS3 35
  • 96.11 (n)
  • 100 (a)
SPCS3 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPCS3 35
  • 95.74 (n)
  • 100 (a)
SPCS3 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spcs3 35
  • 93.33 (n)
  • 100 (a)
Spcs3 16
Spcs3 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPCS3 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPCS3 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spcs3 35
  • 93.52 (n)
  • 99.44 (a)
chicken
(Gallus gallus)
Aves SPCS3 35
  • 85.56 (n)
  • 90 (a)
SPCS3 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPCS3 36
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25776 35
tropical clawed frog
(Silurana tropicalis)
Amphibia spcs3 35
  • 78.15 (n)
  • 86.11 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8388 35
zebrafish
(Danio rerio)
Actinopterygii spcs3 35
  • 76.11 (n)
  • 82.78 (a)
spcs3 36
  • 83 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Spase22-23 35
  • 56.12 (n)
  • 56.5 (a)
Spase22-23 36
  • 56 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea K12H4.4 35
  • 55.81 (n)
  • 48.88 (a)
K12H4.4 36
  • 48 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPC3 36
  • 23 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G05230 35
  • 51.35 (n)
  • 39.19 (a)
rice
(Oryza sativa)
Liliopsida Os01g0131800 35
  • 50.56 (n)
  • 40.83 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5835 36
  • 53 (a)
OneToOne
Species with no ortholog for SPCS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPCS3 Gene

ENSEMBL:
Gene Tree for SPCS3 (if available)
TreeFam:
Gene Tree for SPCS3 (if available)

Paralogs for SPCS3 Gene

Pseudogenes.org Pseudogenes for SPCS3 Gene

genes like me logo Genes that share paralogs with SPCS3: view

No data available for Paralogs for SPCS3 Gene

Variants for SPCS3 Gene

Sequence variations from dbSNP and Humsavar for SPCS3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs14237 -- 176,320,130(+) AGCGT(A/G)ATGGC synonymous-codon, reference
rs1053243 -- 176,332,092(+) AGTTA(C/G/T)ACTTA utr-variant-3-prime
rs1132720 -- 176,332,164(+) TGTCA(A/G)ATTTA utr-variant-3-prime
rs1454160 -- 176,318,187(-) AGGCA(A/G)CCATT upstream-variant-2KB
rs1454161 -- 176,318,154(-) AGTGA(A/C/T)GGACC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SPCS3 Gene

Variant ID Type Subtype PubMed ID
esv2728772 CNV Deletion 23290073
esv34137 CNV Loss 18971310

Relevant External Links for SPCS3 Gene

HapMap Linkage Disequilibrium report
SPCS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPCS3 Gene

Disorders for SPCS3 Gene

Relevant External Links for SPCS3

Genetic Association Database (GAD)
SPCS3
Human Genome Epidemiology (HuGE) Navigator
SPCS3
genes like me logo Genes that share disorders with SPCS3: view

No data available for UniProtKB/Swiss-Prot for SPCS3 Gene

Publications for SPCS3 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4

Products for SPCS3 Gene

Sources for SPCS3 Gene

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