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Aliases for SPCS3 Gene

Aliases for SPCS3 Gene

  • Signal Peptidase Complex Subunit 3 2 3 5
  • Microsomal Signal Peptidase 22/23 KDa Subunit 3 4
  • SPase 22/23 KDa Subunit 3 4
  • SPC22/23 3 4
  • Signal Peptidase Complex Subunit 3 Homolog (S. Cerevisiae) 2
  • Microsomal Signal Peptidase 23 KDa Subunit 3
  • Signal Peptidase Complex Subunit 3 Homolog 3
  • SPase 22 KDa Subunit 3
  • EC 3.4.-.- 4
  • PRO3567 3
  • YLR066W 3
  • SPC22 4
  • SPC3 3

External Ids for SPCS3 Gene

Previous GeneCards Identifiers for SPCS3 Gene

  • GC04P177617
  • GC04P177478
  • GC04P177241
  • GC04P172992

Summaries for SPCS3 Gene

GeneCards Summary for SPCS3 Gene

SPCS3 (Signal Peptidase Complex Subunit 3) is a Protein Coding gene. Among its related pathways are Protein export and Gene Expression. GO annotations related to this gene include peptidase activity.

UniProtKB/Swiss-Prot for SPCS3 Gene

  • Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPCS3 Gene

Genomics for SPCS3 Gene

Regulatory Elements for SPCS3 Gene

Enhancers for SPCS3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SPCS3 on UCSC Golden Path with GeneCards custom track

Promoters for SPCS3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SPCS3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPCS3 Gene

Chromosome:
4
Start:
176,319,939 bp from pter
End:
176,332,245 bp from pter
Size:
12,307 bases
Orientation:
Plus strand

Genomic View for SPCS3 Gene

Genes around SPCS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPCS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPCS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPCS3 Gene

Proteins for SPCS3 Gene

  • Protein details for SPCS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61009-SPCS3_HUMAN
    Recommended name:
    Signal peptidase complex subunit 3
    Protein Accession:
    P61009
    Secondary Accessions:
    • P12280
    • Q9H0S7

    Protein attributes for SPCS3 Gene

    Size:
    180 amino acids
    Molecular mass:
    20313 Da
    Quaternary structure:
    • Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3.

neXtProt entry for SPCS3 Gene

Proteomics data for SPCS3 Gene at MOPED

Post-translational modifications for SPCS3 Gene

  • Ubiquitination at Lys 49, Lys 117, and Lys 137
  • Glycosylation at Asn 141
  • Modification sites at PhosphoSitePlus

Other Protein References for SPCS3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SPCS3 Gene

Domains & Families for SPCS3 Gene

Protein Domains for SPCS3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SPCS3 Gene

Graphical View of Domain Structure for InterPro Entry

P61009

UniProtKB/Swiss-Prot:

SPCS3_HUMAN :
  • Belongs to the SPCS3 family.
Family:
  • Belongs to the SPCS3 family.
genes like me logo Genes that share domains with SPCS3: view

No data available for Gene Families for SPCS3 Gene

Function for SPCS3 Gene

Molecular function for SPCS3 Gene

UniProtKB/Swiss-Prot Function:
Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.

Enzyme Numbers (IUBMB) for SPCS3 Gene

genes like me logo Genes that share phenotypes with SPCS3: view

Animal Model Products

miRNA for SPCS3 Gene

miRTarBase miRNAs that target SPCS3

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPCS3 Gene

Localization for SPCS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPCS3 Gene

Microsome membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPCS3 Gene COMPARTMENTS Subcellular localization image for SPCS3 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SPCS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with SPCS3: view

Pathways & Interactions for SPCS3 Gene

genes like me logo Genes that share pathways with SPCS3: view

Interacting Proteins for SPCS3 Gene

Gene Ontology (GO) - Biological Process for SPCS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006465 signal peptide processing IEA --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with SPCS3: view

No data available for SIGNOR curated interactions for SPCS3 Gene

Drugs & Compounds for SPCS3 Gene

No Compound Related Data Available

Transcripts for SPCS3 Gene

Unigene Clusters for SPCS3 Gene

Signal peptidase complex subunit 3 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPCS3 Gene

No ASD Table

Relevant External Links for SPCS3 Gene

GeneLoc Exon Structure for
SPCS3
ECgene alternative splicing isoforms for
SPCS3

Expression for SPCS3 Gene

mRNA expression in normal human tissues for SPCS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SPCS3 Gene

This gene is overexpressed in Nasal epithelium (17.8) and Tlymphocyte (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPCS3 Gene



SOURCE GeneReport for Unigene cluster for SPCS3 Gene Hs.42194

genes like me logo Genes that share expression patterns with SPCS3: view

Protein tissue co-expression partners for SPCS3 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SPCS3 Gene

Orthologs for SPCS3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SPCS3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SPCS3 35
  • 96.11 (n)
  • 100 (a)
SPCS3 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPCS3 35
  • 95.74 (n)
  • 100 (a)
SPCS3 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spcs3 35
  • 93.33 (n)
  • 100 (a)
Spcs3 16
Spcs3 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SPCS3 35
  • 99.44 (n)
  • 99.44 (a)
SPCS3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spcs3 35
  • 93.52 (n)
  • 99.44 (a)
oppossum
(Monodelphis domestica)
Mammalia SPCS3 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPCS3 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPCS3 35
  • 85.56 (n)
  • 90 (a)
SPCS3 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPCS3 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spcs3 35
  • 78.15 (n)
  • 86.11 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25776 35
zebrafish
(Danio rerio)
Actinopterygii spcs3 35
  • 76.11 (n)
  • 82.78 (a)
spcs3 36
  • 83 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8388 35
fruit fly
(Drosophila melanogaster)
Insecta Spase22-23 35
  • 56.12 (n)
  • 56.5 (a)
Spase22-23 36
  • 56 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea K12H4.4 35
  • 55.81 (n)
  • 48.88 (a)
K12H4.4 36
  • 48 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPC3 36
  • 23 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G05230 35
  • 51.35 (n)
  • 39.19 (a)
rice
(Oryza sativa)
Liliopsida Os01g0131800 35
  • 50.56 (n)
  • 40.83 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5835 36
  • 53 (a)
OneToOne
Species with no ortholog for SPCS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPCS3 Gene

ENSEMBL:
Gene Tree for SPCS3 (if available)
TreeFam:
Gene Tree for SPCS3 (if available)

Paralogs for SPCS3 Gene

Pseudogenes.org Pseudogenes for SPCS3 Gene

genes like me logo Genes that share paralogs with SPCS3: view

No data available for Paralogs for SPCS3 Gene

Variants for SPCS3 Gene

Sequence variations from dbSNP and Humsavar for SPCS3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs14237 -- 176,320,130(+) AGCGT(A/G)ATGGC reference, synonymous-codon
rs1132720 -- 176,332,164(+) TGTCA(A/G)ATTTA utr-variant-3-prime
rs1053243 -- 176,332,092(+) AGTTA(C/G/T)ACTTA utr-variant-3-prime
rs1454160 -- 176,318,187(-) AGGCA(A/G)CCATT upstream-variant-2KB
rs1454161 -- 176,318,154(-) AGTGA(A/C/T)GGACC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SPCS3 Gene

Variant ID Type Subtype PubMed ID
esv2728772 CNV Deletion 23290073
esv34137 CNV Loss 18971310

Variation tolerance for SPCS3 Gene

Residual Variation Intolerance Score: 55.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPCS3 Gene

HapMap Linkage Disequilibrium report
SPCS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPCS3 Gene

Disorders for SPCS3 Gene

Relevant External Links for SPCS3

Genetic Association Database (GAD)
SPCS3
Human Genome Epidemiology (HuGE) Navigator
SPCS3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPCS3

No disorders were found for SPCS3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPCS3 Gene

Publications for SPCS3 Gene

  1. Defective minor spliceosome mRNA processing results in isolated familial growth hormone deficiency. (PMID: 24480542) Argente J. … PAcrez-Jurado L.A. (EMBO Mol Med 2014) 2 3 67
  2. Membrane topology of the 12- and the 25-kDa subunits of the mammalian signal peptidase complex. (PMID: 8632014) Kalies K.-U. … Hartmann E. (J. Biol. Chem. 1996) 2 3
  3. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3

Products for SPCS3 Gene

Sources for SPCS3 Gene

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