SPCS3 Gene
protein-coding GIFtS: 50
GCID: GC04P177241
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|
signal peptidase complex subunit 3 homolog (S. cerevisiae)
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Aliases
for SPCS3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Signal Peptidase Complex Subunit 3 Homolog (S. Cerevisiae)1 2 | | FLJ226491 | | SPC22/231 2 3 | | Microsomal Signal Peptidase 23 KDa Subunit2 | | PRO35671 2 | | Signal Peptidase Complex Subunit 32 | | SPC31 2 | | SPase 22 KDa Subunit2 | | YLR066W1 2 | | EC 3.4.-.-3 | | Microsomal Signal Peptidase 22/23 KDa Subunit2 3 | | SPC223 | | SPase 22/23 KDa Subunit2 3 | | |
Export aliases for SPCS3 gene to outside databasesPrevious GC identifers: GC04P177617 GC04P177478 GC04P172992 |
Summaries
for SPCS3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SPCS3_HUMAN, P61009Function: Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins asthey are translocated into the lumen of the endoplasmic reticulum (By similarity)
|
Genomic Views
for SPCS3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPCS3 gene promoter:
LHX3b/Lhx3b Pbx1a MEF-2 Meis-1b MEF-2A S8 LHX3a/Lhx3a Meis-1a aMEF-2 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPCS3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPCS3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q34.2 Ensembl cytogenetic band: 4q34.2 HGNC cytogenetic band: 4q34.2SPCS3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P177241: view genomic region
(about GC identifiers)
Start:
|
177,241,090 bp from pter |
End:
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177,253,396 bp from pter |
Size:
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12,307 bases |
Orientation:
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plus strand |
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Proteins
for SPCS3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPCS3_HUMAN, P61009 (See
protein sequence)Recommended Name: Signal peptidase complex subunit 3 Size: 180 amino acids; 20313 Da
Subunit: Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1,SPCS2 and SPCS3 (By similarity)
Subcellular location: Microsome membrane; Single-pass type II membrane protein (By similarity). Endoplasmic reticulummembrane; Single-pass type II membrane protein (By similarity)
Secondary accessions: P12280 Q9H0S7Explore the universe of human proteins at neXtProt for SPCS3: NX_P61009
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P61009
SPCS3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_068747.1
ENSEMBL proteins: ENSP00000427463 Reactome Protein details: P61009
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
SPCS3 for ontologies About GeneDecksing
SPCS3 Antibody Products:
Assay Products for SPCS3: |
Protein
Domains /
Families
for SPCS3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SPCS3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P61009ProtoNet protein and cluster: P61009 1 Blocks protein family: IPB007653 Signal peptidase subunit
UniProtKB/Swiss-Prot: SPCS3_HUMAN, P61009Similarity: Belongs to the SPCS3 family |
Function
for SPCS3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SPCS3_HUMAN, P61009Function: Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins asthey are translocated into the lumen of the endoplasmic reticulum (By similarity)Enzyme Number (IUBMB): EC 3.4.-.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPCS3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPCS3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SPCS3 (NM_021928) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPCS3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPCS3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPCS3 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008233 | peptidase activity |
IEA | -- |
SPCS3 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SPCS3:
|
Pathways & Interactions
for SPCS3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) | | | 2 | Synthesis of PB1-F2 | | | 3 | Protein export | | | 4 | Generic Transcription Pathway | | | 5 | Insulin Processing | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/9 
Reactome Pathways for SPCS3 (see all 9)
1 
Kegg Pathway (Kegg details for SPCS3):
SPCS3 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPCS3
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006112 | energy reserve metabolic process |
TAS | -- | | GO:0006412 | translation |
TAS | -- | | GO:0006465 | signal peptide processing |
IEA | -- | | GO:0006508 | proteolysis |
IEA | -- | | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane |
TAS | -- |
SPCS3 for ontologies About GeneDecksing
|
Drugs & Compounds
for SPCS3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPCS3
Search CenterWatch for drugs/clinical trials and news about SPCS3
|
Transcripts
for SPCS3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPCS3 gene: NM_021928.3 Unigene Cluster for SPCS3: Signal peptidase complex subunit 3 homolog (S. cerevisiae) Hs.42194 [show with all ESTs]Unigene Representative Sequence: NM_0219284 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000503362(uc003iur.4) ENST00000507678 ENST00000513139 ENST00000507001
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPCS3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPCS3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SPCS3 (NM_021928) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPCS3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPCS3 |
Additional cDNA sequence: AK026302.1 AL136660.1 AY359044.1 BC047290.1 14 DOTS entries: DT.113788 DT.97844495 DT.91963153 DT.86854163 DT.99949409 DT.40295589 DT.75126785 DT.95275395 DT.97844496 DT.100739907 DT.121256623 DT.95165450 DT.97844498 DT.91889751 24/238 AceView cDNA sequences (see all 238): AA101804 AI016013 AK026302 W93981 CR603061 AA926734 CF529375 BC043490 BF002291 BC047290 AW873817 BX494036 AI077414 AI857664 CA867773 AA663063 AA954542 BC053883 AA766881 BQ227903 N29424 AA101782 BU633751 AA411686
GeneLoc Exon Structure
|
Expression
for SPCS3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPCS3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAATACTGA
About this image
See SPCS3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPCS3
SOURCE GeneReport for Unigene cluster: Hs.42194
SABiosciences Custom PCR Arrays for SPCS3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPCS3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPCS3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPCS3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPCS3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPCS3 |
Orthologs
for SPCS3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SPCS3 gene from 9/28 species (see all 28) About this table
ENSEMBL Gene Tree for SPCS3 (if available)
TreeFam Gene Tree for SPCS3 (if available) |
Paralogs
for SPCS3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SPCS3 gene
SPCS3 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SPCS3
PGOHUM00000244456
|
Genomic Variants
for SPCS3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SPCS3
1 CNV: 47949 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPCS3 |
|
Disorders
/ Diseases
for SPCS3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SPCS3 for disorders About GeneDecksing
1  disease for SPCS3: About MalaCardsmalaria
Human Genome Epidemiology (HuGE) Navigator: SPCS3 (1 document)
Export disorders for SPCS3 gene to outside databases
|
Publications
for SPCS3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPCS3 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with SPCS3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
|
External Searches for SPCS3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SPCS3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SPCS3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPCS3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SPCS3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SPCS3 gene:
Search GeneIP for patents involving SPCS3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPCS3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPCS3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPCS3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPCS3 | | | OriGene Protein Over-expression Lysate for SPCS3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPCS3 | | OriGene 3'-UTR Clone for SPCS3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPCS3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPCS3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SPCS3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPCS3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPCS3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPCS3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPCS3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPCS3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPCS3 |
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| | | | Search Tocris compounds for SPCS3 |
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 | | | SPCS3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPCS3 |
|  |  |  | | | | ThermoFisher Antibodies for SPCS3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPCS3 |
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