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Aliases for SPCS3 Gene

Aliases for SPCS3 Gene

  • Signal Peptidase Complex Subunit 3 2 3 5
  • Microsomal Signal Peptidase 22/23 KDa Subunit 3 4
  • SPase 22/23 KDa Subunit 3 4
  • SPC22/23 3 4
  • Signal Peptidase Complex Subunit 3 Homolog (S. Cerevisiae) 2
  • Microsomal Signal Peptidase 23 KDa Subunit 3
  • Signal Peptidase Complex Subunit 3 Homolog 3
  • SPase 22 KDa Subunit 3
  • EC 3.4.-.- 4
  • PRO3567 3
  • YLR066W 3
  • SPC22 4
  • SPC3 3

External Ids for SPCS3 Gene

Previous GeneCards Identifiers for SPCS3 Gene

  • GC04P177617
  • GC04P177478
  • GC04P177241
  • GC04P172992

Summaries for SPCS3 Gene

GeneCards Summary for SPCS3 Gene

SPCS3 (Signal Peptidase Complex Subunit 3) is a Protein Coding gene. Among its related pathways are Incretin synthesis, secretion, and inactivation and Peptide hormone metabolism. GO annotations related to this gene include peptidase activity.

UniProtKB/Swiss-Prot for SPCS3 Gene

  • Component of the microsomal signal peptidase complex which removes signal peptides and other N-terminal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPCS3 Gene

Genomics for SPCS3 Gene

Regulatory Elements for SPCS3 Gene

Enhancers for SPCS3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F176267 1.7 FANTOM5 Ensembl ENCODE 5.2 -48.7 -48728 8.1 PKNOX1 INSM2 SIN3A RAD21 ZBTB40 ZEB1 ZNF366 RCOR1 FOS ZNF263 ASB5 SPCS3 GC04M176057
GH04F176358 0.2 ENCODE 4.8 +38.2 38226 0.2 JUNB WDR17 SPCS3 ENSG00000248980 LOC100421630
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SPCS3 on UCSC Golden Path with GeneCards custom track

Promoters for SPCS3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001254780 861 4001 PKNOX1 ATF1 ARID4B SIN3A FEZF1 DMAP1 ZNF48 YY1 ELK1 GATA2

Genomic Location for SPCS3 Gene

Chromosome:
4
Start:
176,319,939 bp from pter
End:
176,332,245 bp from pter
Size:
12,307 bases
Orientation:
Plus strand

Genomic View for SPCS3 Gene

Genes around SPCS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPCS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPCS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPCS3 Gene

Proteins for SPCS3 Gene

  • Protein details for SPCS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61009-SPCS3_HUMAN
    Recommended name:
    Signal peptidase complex subunit 3
    Protein Accession:
    P61009
    Secondary Accessions:
    • P12280
    • Q9H0S7

    Protein attributes for SPCS3 Gene

    Size:
    180 amino acids
    Molecular mass:
    20313 Da
    Quaternary structure:
    • Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3.

neXtProt entry for SPCS3 Gene

Post-translational modifications for SPCS3 Gene

  • Ubiquitination at Lys 49, Lys 117, and Lys 137
  • Glycosylation at Asn 141
  • Modification sites at PhosphoSitePlus

Other Protein References for SPCS3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for SPCS3
  • Santa Cruz Biotechnology (SCBT) Antibodies for SPCS3

No data available for DME Specific Peptides for SPCS3 Gene

Domains & Families for SPCS3 Gene

Protein Domains for SPCS3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SPCS3 Gene

Graphical View of Domain Structure for InterPro Entry

P61009

UniProtKB/Swiss-Prot:

SPCS3_HUMAN :
  • Belongs to the SPCS3 family.
Family:
  • Belongs to the SPCS3 family.
genes like me logo Genes that share domains with SPCS3: view

No data available for Gene Families for SPCS3 Gene

Function for SPCS3 Gene

Molecular function for SPCS3 Gene

UniProtKB/Swiss-Prot Function:
Component of the microsomal signal peptidase complex which removes signal peptides and other N-terminal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.

Enzyme Numbers (IUBMB) for SPCS3 Gene

Gene Ontology (GO) - Molecular Function for SPCS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with SPCS3: view
genes like me logo Genes that share phenotypes with SPCS3: view

Animal Model Products

miRNA for SPCS3 Gene

miRTarBase miRNAs that target SPCS3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPCS3 Gene

Localization for SPCS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPCS3 Gene

Microsome membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPCS3 Gene COMPARTMENTS Subcellular localization image for SPCS3 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SPCS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0005787 signal peptidase complex IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SPCS3: view

Pathways & Interactions for SPCS3 Gene

genes like me logo Genes that share pathways with SPCS3: view

Gene Ontology (GO) - Biological Process for SPCS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006465 signal peptide processing IEA --
GO:0006508 proteolysis IEA,IDA 27499293
genes like me logo Genes that share ontologies with SPCS3: view

No data available for SIGNOR curated interactions for SPCS3 Gene

Transcripts for SPCS3 Gene

Unigene Clusters for SPCS3 Gene

Signal peptidase complex subunit 3 homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPCS3 Gene

No ASD Table

Relevant External Links for SPCS3 Gene

GeneLoc Exon Structure for
SPCS3
ECgene alternative splicing isoforms for
SPCS3

Expression for SPCS3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPCS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SPCS3 Gene

This gene is overexpressed in Nasal epithelium (17.8) and Tlymphocyte (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SPCS3 Gene



Protein tissue co-expression partners for SPCS3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SPCS3 Gene:

SPCS3

SOURCE GeneReport for Unigene cluster for SPCS3 Gene:

Hs.42194
genes like me logo Genes that share expression patterns with SPCS3: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SPCS3 Gene

Orthologs for SPCS3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SPCS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPCS3 34 35
  • 99.44 (n)
cow
(Bos Taurus)
Mammalia SPCS3 34 35
  • 96.11 (n)
oppossum
(Monodelphis domestica)
Mammalia SPCS3 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPCS3 34 35
  • 95.74 (n)
rat
(Rattus norvegicus)
Mammalia Spcs3 34
  • 93.52 (n)
mouse
(Mus musculus)
Mammalia Spcs3 34 16 35
  • 93.33 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SPCS3 35
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPCS3 34 35
  • 85.56 (n)
lizard
(Anolis carolinensis)
Reptilia SPCS3 35
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spcs3 34
  • 78.15 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25776 34
zebrafish
(Danio rerio)
Actinopterygii spcs3 34 35
  • 76.11 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8388 34
fruit fly
(Drosophila melanogaster)
Insecta Spase22-23 34 35
  • 56.12 (n)
worm
(Caenorhabditis elegans)
Secernentea K12H4.4 34 35
  • 55.81 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPC3 35
  • 23 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G05230 34
  • 51.35 (n)
rice
(Oryza sativa)
Liliopsida Os01g0131800 34
  • 50.56 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5835 35
  • 53 (a)
OneToOne
Species where no ortholog for SPCS3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPCS3 Gene

ENSEMBL:
Gene Tree for SPCS3 (if available)
TreeFam:
Gene Tree for SPCS3 (if available)

Paralogs for SPCS3 Gene

Pseudogenes.org Pseudogenes for SPCS3 Gene

genes like me logo Genes that share paralogs with SPCS3: view

No data available for Paralogs for SPCS3 Gene

Variants for SPCS3 Gene

Sequence variations from dbSNP and Humsavar for SPCS3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10013572 -- 176,332,270(+) GACCA(A/C)ACCAT downstream-variant-500B
rs10520344 -- 176,328,894(+) AATAC(C/T)TGTTT utr-variant-3-prime
rs10520345 -- 176,331,073(+) GTCTC(A/G)TCAGC utr-variant-3-prime
rs1053243 -- 176,332,092(+) AGTTA(C/T)ACTTA utr-variant-3-prime
rs111259291 -- 176,323,768(+) GCATA(C/T)TGTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPCS3 Gene

Variant ID Type Subtype PubMed ID
esv2728772 CNV deletion 23290073
esv34137 CNV loss 18971310
esv3603274 CNV gain 21293372
esv3894072 CNV loss 25118596

Variation tolerance for SPCS3 Gene

Residual Variation Intolerance Score: 55.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPCS3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPCS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPCS3 Gene

Disorders for SPCS3 Gene

Relevant External Links for SPCS3

Genetic Association Database (GAD)
SPCS3
Human Genome Epidemiology (HuGE) Navigator
SPCS3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPCS3

No disorders were found for SPCS3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPCS3 Gene

Publications for SPCS3 Gene

  1. Inverting the Topology of a Transmembrane Protein by Regulating the Translocation of the First Transmembrane Helix. (PMID: 27499293) Chen Q. … Ye J. (Mol. Cell 2016) 3 4 64
  2. Defective minor spliceosome mRNA processing results in isolated familial growth hormone deficiency. (PMID: 24480542) Argente J. … PAcrez-Jurado L.A. (EMBO Mol Med 2014) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for SPCS3 Gene

Sources for SPCS3 Gene

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