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Aliases for SPCS2 Gene

Aliases for SPCS2 Gene

  • Signal Peptidase Complex Subunit 2 2 3 5
  • Signal Peptidase Complex Subunit 2 Homolog (S. Cerevisiae) 2
  • Microsomal Signal Peptidase 25 KDa Subunit 4
  • Signal Peptidase 25kDa Subunit 2
  • SPase 25 KDa Subunit 4
  • EC 3.4.-.- 4
  • KIAA0102 4
  • SPC25 4

External Ids for SPCS2 Gene

Previous GeneCards Identifiers for SPCS2 Gene

  • GC11P074339
  • GC11P074660
  • GC11P070957
  • GC11P074955
  • GC11P074978
  • GC11P075000
  • GC11P075119

Summaries for SPCS2 Gene

GeneCards Summary for SPCS2 Gene

SPCS2 (Signal Peptidase Complex Subunit 2) is a Protein Coding gene. Among its related pathways are Incretin synthesis, secretion, and inactivation and Peptide hormone metabolism. GO annotations related to this gene include peptidase activity.

UniProtKB/Swiss-Prot for SPCS2 Gene

  • Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPCS2 Gene

Genomics for SPCS2 Gene

Regulatory Elements for SPCS2 Gene

Enhancers for SPCS2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F075022 1.3 Ensembl ENCODE 11.1 +74.1 74128 2.1 ATF1 MLX ARID4B DMAP1 BRCA1 ZNF2 ZNF48 SLC30A9 ZNF143 DEK SPCS2 XRRA1 OR2AT4 SLCO2B1 ENSG00000254429 NEU3 PIR50270 PIR37723
GH11F074988 1 ENCODE 11.6 +39.9 39889 2.0 HDGF ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF263 SP3 SP5 GTF2B XRRA1 POLD3 SPCS2 RNF169 ENSG00000206913 RPS12P22 NEU3 PIRC52
GH11F075049 0.5 ENCODE 10.3 +100.9 100910 1.6 MTA2 IKZF1 NBN XRRA1 SLCO2B1 SPCS2 PIR37723 OR2AT2P
GH11F074459 1.5 FANTOM5 ENCODE 2.8 -487.5 -487452 4.1 HDGF PKNOX1 ARNT MLX ARID4B SIN3A DMAP1 YBX1 YY1 ZNF143 RNF169 ENSG00000206913 KCNE3 POLD3 COA4 ENSG00000254974 SPCS2 C2CD3 ENSG00000254928
GH11F075327 1.8 FANTOM5 Ensembl ENCODE 2.3 +391.2 391240 26.4 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 GDPD5 ARRB1 SNORD15B KLHL35 NEU3 RPS3 ENSG00000254974 UVRAG SPCS2 DGAT2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPCS2 on UCSC Golden Path with GeneCards custom track

Promoters for SPCS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000565424 53 2601 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for SPCS2 Gene

Chromosome:
11
Start:
74,949,247 bp from pter
End:
74,979,031 bp from pter
Size:
29,785 bases
Orientation:
Plus strand

Genomic View for SPCS2 Gene

Genes around SPCS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPCS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPCS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPCS2 Gene

Proteins for SPCS2 Gene

  • Protein details for SPCS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15005-SPCS2_HUMAN
    Recommended name:
    Signal peptidase complex subunit 2
    Protein Accession:
    Q15005
    Secondary Accessions:
    • Q15507
    • Q3KQT0
    • Q641R4
    • Q6FG65
    • Q6IRX0
    • Q6P1P4
    • Q96HU9

    Protein attributes for SPCS2 Gene

    Size:
    226 amino acids
    Molecular mass:
    25003 Da
    Quaternary structure:
    • Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3.
    SequenceCaution:
    • Sequence=AAH08063.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH70276.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH82231.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA03492.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SPCS2 Gene

Post-translational modifications for SPCS2 Gene

  • Ubiquitination at Lys 191 and Lys 195
  • Modification sites at PhosphoSitePlus

Other Protein References for SPCS2 Gene

No data available for DME Specific Peptides for SPCS2 Gene

Domains & Families for SPCS2 Gene

Protein Domains for SPCS2 Gene

Suggested Antigen Peptide Sequences for SPCS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15005

UniProtKB/Swiss-Prot:

SPCS2_HUMAN :
  • Belongs to the SPCS2 family.
Family:
  • Belongs to the SPCS2 family.
genes like me logo Genes that share domains with SPCS2: view

No data available for Gene Families for SPCS2 Gene

Function for SPCS2 Gene

Molecular function for SPCS2 Gene

UniProtKB/Swiss-Prot Function:
Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.

Enzyme Numbers (IUBMB) for SPCS2 Gene

Gene Ontology (GO) - Molecular Function for SPCS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 contributes_to peptidase activity IEA,IBA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with SPCS2: view
genes like me logo Genes that share phenotypes with SPCS2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPCS2 Gene

Localization for SPCS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPCS2 Gene

Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPCS2 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SPCS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005787 signal peptidase complex IEA,IBA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031090 organelle membrane IEA --
genes like me logo Genes that share ontologies with SPCS2: view

Pathways & Interactions for SPCS2 Gene

genes like me logo Genes that share pathways with SPCS2: view

Gene Ontology (GO) - Biological Process for SPCS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006465 signal peptide processing IEA,IBA --
GO:0006508 proteolysis IEA --
GO:0045047 protein targeting to ER IBA --
genes like me logo Genes that share ontologies with SPCS2: view

No data available for SIGNOR curated interactions for SPCS2 Gene

Transcripts for SPCS2 Gene

Unigene Clusters for SPCS2 Gene

Signal peptidase complex subunit 2 homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPCS2 Gene

No ASD Table

Relevant External Links for SPCS2 Gene

GeneLoc Exon Structure for
SPCS2
ECgene alternative splicing isoforms for
SPCS2

Expression for SPCS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPCS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SPCS2 Gene

This gene is overexpressed in Nasal epithelium (28.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SPCS2 Gene



Protein tissue co-expression partners for SPCS2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SPCS2 Gene:

SPCS2

SOURCE GeneReport for Unigene cluster for SPCS2 Gene:

Hs.282700
genes like me logo Genes that share expression patterns with SPCS2: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SPCS2 Gene

Orthologs for SPCS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPCS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPCS2 34 35
  • 99.71 (n)
dog
(Canis familiaris)
Mammalia SPCS2 34 35
  • 92.48 (n)
cow
(Bos Taurus)
Mammalia SPCS2 34 35
  • 91.49 (n)
mouse
(Mus musculus)
Mammalia Spcs2 34 16 35
  • 90.86 (n)
rat
(Rattus norvegicus)
Mammalia Spcs2 34
  • 89.82 (n)
oppossum
(Monodelphis domestica)
Mammalia SPCS2 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPCS2 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPCS2 34 35
  • 79.76 (n)
lizard
(Anolis carolinensis)
Reptilia SPCS2 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10344 34
zebrafish
(Danio rerio)
Actinopterygii spcs2 34 35
  • 70.05 (n)
wufa12g08 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9720 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011842 34
  • 54.88 (n)
fruit fly
(Drosophila melanogaster)
Insecta Spase25 34 35
  • 51.35 (n)
worm
(Caenorhabditis elegans)
Secernentea hpo-21 34 35
  • 48.15 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4833 35
  • 51 (a)
OneToOne
Species where no ortholog for SPCS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPCS2 Gene

ENSEMBL:
Gene Tree for SPCS2 (if available)
TreeFam:
Gene Tree for SPCS2 (if available)

Paralogs for SPCS2 Gene

(1) SIMAP similar genes for SPCS2 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for SPCS2 Gene

genes like me logo Genes that share paralogs with SPCS2: view

No data available for Paralogs for SPCS2 Gene

Variants for SPCS2 Gene

Sequence variations from dbSNP and Humsavar for SPCS2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10706086 -- 74,948,251(+) GTAGT(-/T)CCACC intron-variant, upstream-variant-2KB
rs10708446 -- 74,962,549(+) GAGGC(-/A)AAAAA intron-variant
rs111306834 -- 74,968,816(+) CACCA(C/T)GCCTA intron-variant
rs111335058 -- 74,958,345(+) AAAAT(-/A)GATTG intron-variant
rs111440928 -- 74,950,272(+) TCTGC(-/AAAGTG)AGAGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SPCS2 Gene

Variant ID Type Subtype PubMed ID
nsv832210 CNV gain+loss 17160897
nsv972047 CNV duplication 23825009

Variation tolerance for SPCS2 Gene

Residual Variation Intolerance Score: 56.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPCS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPCS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPCS2 Gene

Disorders for SPCS2 Gene

Relevant External Links for SPCS2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPCS2

No disorders were found for SPCS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPCS2 Gene

Publications for SPCS2 Gene

  1. Defective minor spliceosome mRNA processing results in isolated familial growth hormone deficiency. (PMID: 24480542) Argente J. … PAcrez-Jurado L.A. (EMBO Mol Med 2014) 2 3 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Membrane topology of the 12- and the 25-kDa subunits of the mammalian signal peptidase complex. (PMID: 8632014) Kalies K.-U. … Hartmann E. (J. Biol. Chem. 1996) 2 3 64
  4. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7788527) Nagase T. … Nomura N. (DNA Res. 1995) 3 4 64
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 64

Products for SPCS2 Gene

Sources for SPCS2 Gene

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