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Aliases for SPCS2 Gene

Aliases for SPCS2 Gene

  • Signal Peptidase Complex Subunit 2 Homolog (S. Cerevisiae) 2 3
  • Microsomal Signal Peptidase 25 KDa Subunit 4
  • SPase 25 KDa Subunit 4
  • EC 3.4.-.- 4
  • KIAA0102 4
  • SPC25 4

External Ids for SPCS2 Gene

Summaries for SPCS2 Gene

GeneCards Summary for SPCS2 Gene

SPCS2 (Signal Peptidase Complex Subunit 2 Homolog (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include peptidase activity.

UniProtKB/Swiss-Prot for SPCS2 Gene

  • Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPCS2 Gene

Genomics for SPCS2 Gene

Genomic Location for SPCS2 Gene

Start:
74,949,247 bp from pter
End:
74,979,031 bp from pter
Size:
29,785 bases
Orientation:
Plus strand

Genomic View for SPCS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPCS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPCS2 Gene

Regulatory Elements for SPCS2 Gene

Proteins for SPCS2 Gene

  • Protein details for SPCS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15005-SPCS2_HUMAN
    Recommended name:
    Signal peptidase complex subunit 2
    Protein Accession:
    Q15005
    Secondary Accessions:
    • Q15507
    • Q3KQT0
    • Q641R4
    • Q6FG65
    • Q6IRX0
    • Q6P1P4
    • Q96HU9

    Protein attributes for SPCS2 Gene

    Size:
    226 amino acids
    Molecular mass:
    25003 Da
    Quaternary structure:
    • Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3.
    SequenceCaution:
    • Sequence=AAH08063.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH70276.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH82231.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA03492.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SPCS2 Gene

Proteomics data for SPCS2 Gene at MOPED

Post-translational modifications for SPCS2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys191 and Lys195

Other Protein References for SPCS2 Gene

No data available for DME Specific Peptides for SPCS2 Gene

Domains for SPCS2 Gene

Protein Domains for SPCS2 Gene

UniProtKB/Swiss-Prot:

SPCS2_HUMAN
Family:
  • Belongs to the SPCS2 family.:
    • Q15005
genes like me logo Genes that share domains with SPCS2: view

No data available for Gene Families for SPCS2 Gene

Function for SPCS2 Gene

Molecular function for SPCS2 Gene

UniProtKB/Swiss-Prot Function: Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.

Enzyme Numbers (IUBMB) for SPCS2 Gene

Gene Ontology (GO) - Molecular Function for SPCS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA --
genes like me logo Genes that share ontologies with SPCS2: view

miRNA for SPCS2 Gene

miRTarBase miRNAs that target SPCS2

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SPCS2 Gene

Localization for SPCS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPCS2 Gene

Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPCS2 Gene COMPARTMENTS Subcellular localization image for SPCS2 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SPCS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005787 signal peptidase complex IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SPCS2: view

Pathways for SPCS2 Gene

genes like me logo Genes that share pathways with SPCS2: view

Pathways by source for SPCS2 Gene

1 KEGG pathway for SPCS2 Gene

Gene Ontology (GO) - Biological Process for SPCS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS --
GO:0006465 signal peptide processing IEA --
GO:0006508 proteolysis --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with SPCS2: view

Transcripts for SPCS2 Gene

Unigene Clusters for SPCS2 Gene

Signal peptidase complex subunit 2 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPCS2 Gene

No ASD Table

Relevant External Links for SPCS2 Gene

GeneLoc Exon Structure for
SPCS2
ECgene alternative splicing isoforms for
SPCS2

Expression for SPCS2 Gene

mRNA expression in normal human tissues for SPCS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPCS2 Gene

SOURCE GeneReport for Unigene cluster for SPCS2 Gene Hs.282700

genes like me logo Genes that share expressions with SPCS2: view

Orthologs for SPCS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPCS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPCS2 36
  • 99.71 (n)
  • 99.56 (a)
SPCS2 37
  • 88 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPCS2 36
  • 91.49 (n)
  • 98.96 (a)
SPCS2 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPCS2 36
  • 92.48 (n)
  • 95.13 (a)
SPCS2 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spcs2 36
  • 90.86 (n)
  • 95.58 (a)
Spcs2 16
Spcs2 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPCS2 37
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPCS2 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spcs2 36
  • 89.82 (n)
  • 95.13 (a)
chicken
(Gallus gallus)
Aves SPCS2 36
  • 79.76 (n)
  • 90.82 (a)
SPCS2 37
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPCS2 37
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10344 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9720 36
zebrafish
(Danio rerio)
Actinopterygii spcs2 36
  • 70.05 (n)
  • 72.08 (a)
spcs2 37
  • 69 (a)
OneToOne
wufa12g08 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011842 36
  • 54.88 (n)
  • 47.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta Spase25 36
  • 51.35 (n)
  • 41.08 (a)
Spase25 37
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea hpo-21 36
  • 48.15 (n)
  • 42.11 (a)
hpo-21 37
  • 38 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4833 37
  • 51 (a)
OneToOne
Species with no ortholog for SPCS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPCS2 Gene

ENSEMBL:
Gene Tree for SPCS2 (if available)
TreeFam:
Gene Tree for SPCS2 (if available)

Paralogs for SPCS2 Gene

Selected SIMAP similar genes for SPCS2 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for SPCS2 Gene

genes like me logo Genes that share paralogs with SPCS2: view

No data available for Paralogs for SPCS2 Gene

Variants for SPCS2 Gene

Sequence variations from dbSNP and Humsavar for SPCS2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs487226 -- 74,976,296(-) ACTAC(G/T)TTCTT intron-variant
rs493001 -- 74,967,158(+) acatt(G/T)ccccc intron-variant
rs496698 -- 74,967,530(-) tcaag(C/T)gattc intron-variant
rs503994 -- 74,961,765(-) ggatc(A/G)tttga intron-variant
rs511021 -- 74,965,374(-) AATTT(G/T)ATTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPCS2 Gene

Variant ID Type Subtype PubMed ID
nsv832210 CNV Gain+Loss 17160897

Relevant External Links for SPCS2 Gene

HapMap Linkage Disequilibrium report
SPCS2

Disorders for SPCS2 Gene

No disorders were found for SPCS2 Gene.

No data available for UniProtKB/Swiss-Prot for SPCS2 Gene

Publications for SPCS2 Gene

  1. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7788527) Nagase T. … Nomura N. (DNA Res. 1995) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6. (PMID: 20029029) Deribe Y.L. … Dikic I. (Sci Signal 2009) 3

Products for SPCS2 Gene

Sources for SPCS2 Gene

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