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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPCS2 Gene

protein-coding   GIFtS: 49
GCID: GC11P074660

signal peptidase complex subunit 2 homolog (S. cerevisiae)

  Search for SPCS2
in our new
 Human Malady Compendium 
Biological research products
for SPCS2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Signal Peptidase Complex Subunit 2 Homolog (S. Cerevisiae)1 2     Signal Peptidase 25kDa Subunit2
KIAA01021 3     Signal Peptidase Complex Subunit 22
Microsomal Signal Peptidase 25 KDa Subunit2 3     EC 3.4.-.-3
SPase 25 KDa Subunit2 3     SPC253

External Ids:    HGNC: 289621   Entrez Gene: 97892   Ensembl: ENSG000001183637   UniProtKB: Q150053   

Export aliases for SPCS2 gene to outside databases

Previous GC identifers: GC11P074339 GC11P070957


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SPCS2_HUMAN, Q15005
Function: Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as
they are translocated into the lumen of the endoplasmic reticulum (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPCS2 gene promoter:
         COUP-TF1   E2F-3a   E2F-4   E2F-5   COUP   Nkx2-5   E2F-2   E2F-1   E2F   COUP-TF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPCS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SPCS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPCS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.4   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13.4

SPCS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPCS2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P074660:  view genomic region     (about GC identifiers)

Start:
74,660,292 bp from pter      End:
74,690,076 bp from pter
Size:
29,785 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SPCS2_HUMAN, Q15005 (See protein sequence)
Recommended Name: Signal peptidase complex subunit 2  
Size: 226 amino acids; 25003 Da
Subunit: Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1,
SPCS2 and SPCS3 (By similarity)
Subcellular location: Microsome membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum membrane;
Multi-pass membrane protein (By similarity)
Sequence caution: Sequence=AAH08063.3; Type=Erroneous initiation; Sequence=AAH70276.2; Type=Erroneous initiation;
Sequence=AAH82231.2; Type=Erroneous initiation; Sequence=BAA03492.1; Type=Erroneous initiation;
Secondary accessions: Q15507 Q3KQT0 Q641R4 Q6FG65 Q6IRX0 Q6P1P4 Q96HU9

Explore the universe of human proteins at neXtProt for SPCS2: NX_Q15005

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15005

  • SPCS2 Protein expression data from MOPED and PaxDb:    About this image 
    SPCS2 Protein Expression
    REFSEQ proteins: NP_055567.2  
    ENSEMBL proteins: 
     ENSP00000263672   ENSP00000433439   ENSP00000434248   ENSP00000436759   ENSP00000434706  
    Reactome Protein details: Q15005
    Human Recombinant Protein Products for SPCS2: 
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    OriGene Protein Over-expression Lysate: SPCS2
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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SPCS2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005787signal peptidase complex IEA--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005792microsome ----
    GO:0016021integral to membrane IEA--

    SPCS2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SPCS2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR009582 SigPept_cplx_su2

    Graphical View of Domain Structure for InterPro Entry Q15005

    ProtoNet protein and cluster: Q15005

    1 Blocks protein family: IPB009582 Microsomal signal peptidase 25 kDa subunit

    UniProtKB/Swiss-Prot: SPCS2_HUMAN, Q15005
    Similarity: Belongs to the SPCS2 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPCS2_HUMAN, Q15005
    Function: Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as
    they are translocated into the lumen of the endoplasmic reticulum (By similarity)

         Enzyme Number (IUBMB): EC 3.4.-.-1

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008233peptidase activity IEA--
         
    SPCS2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SPCS2 

    miRNA
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    Browse 3'-UTR reporter clones for miRNA target validation
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPCS2
    8/65 QIAGEN miScript miRNA Assays for microRNAs that regulate SPCS2 (see all 65):
    hsa-miR-411* hsa-miR-548j hsa-miR-485-3p hsa-miR-890 hsa-miR-548a-5p hsa-miR-3148 hsa-miR-761 hsa-miR-34c-5p
    SwitchGear 3'UTR luciferase reporter plasmidSPCS2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPCS2 (see all 4)
    OriGene shRNA RFP: SPCS2
    OriGene siRNA: SPCS2
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    Sirion Biotech Custom design and validation of potent shRNA sequences against SPCS2 

    Gene Editing
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPCS2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
    Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)1.00
    Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)0.78
    Incretin Synthesis, Secretion, and Inactivation0.89
    Synthesis, Secretion, and Deacylation of Ghrelin0.46
    2Synthesis of PB1-F2
    SRP-dependent cotranslational protein targeting to membrane0.77
    Translation0.57
    3Protein export
    Protein export1.00
    4Generic Transcription Pathway
    Gene Expression0.46
    5Insulin Processing
    Peptide hormone metabolism0.39

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/9        Reactome Pathways for SPCS2 (see all 9)
        Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
    Incretin Synthesis, Secretion, and Inactivation
    Translation
    SRP-dependent cotranslational protein targeting to membrane
    Synthesis, Secretion, and Deacylation of Ghrelin


    1         Kegg Pathway  (Kegg details for SPCS2):
        Protein export


    SPCS2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPCS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/89 Interacting proteins for SPCS2 (Q150052, 3 ENSP000002636724) via UniProtKB, MINT, STRING, and/or I2D (see all 89)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STMN3Q9NZ722, 3, ENSP000003590704MINT-64586 I2D: score=4 STRING: ENSP00000359070
    TEFMQ96QE52, 3, ENSP000003065744MINT-64585 I2D: score=4 STRING: ENSP00000306574
    TNFRSF14Q929563, ENSP000003479484I2D: score=1 STRING: ENSP00000347948
    DDX56Q9NY933, ENSP000002587724I2D: score=1 STRING: ENSP00000258772
    EGFRP005333, ENSP000002754934I2D: score=2 STRING: ENSP00000275493
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006412translation TAS--
    GO:0006465signal peptide processing IEA--
    GO:0006508proteolysis IEA--
    GO:0006614SRP-dependent cotranslational protein targeting to membrane TAS--

    SPCS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPCS2
    Search CenterWatch for drugs/clinical trials and news about SPCS2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SPCS2 gene: 
    NM_014752.2  

    Unigene Clusters for SPCS2:

    Signal peptidase complex subunit 2 homolog (S. cerevisiae)
    Hs.282700  [show with all ESTs], Hs.719927  [show with all ESTs]
    Unigene Representative Sequences: AK091429, BF214514
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263672(uc001ovu.2) ENST00000530257 ENST00000526361 ENST00000532972
    ENST00000527290 ENST00000528265 ENST00000527225 ENST00000526883

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPCS2
    8/65 QIAGEN miScript miRNA Assays for microRNAs that regulate SPCS2 (see all 65):
    hsa-miR-411* hsa-miR-548j hsa-miR-485-3p hsa-miR-890 hsa-miR-548a-5p hsa-miR-3148 hsa-miR-761 hsa-miR-34c-5p
    SwitchGear 3'UTR luciferase reporter plasmidSPCS2 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPCS2 (see all 4)
    OriGene shRNA RFP: SPCS2
    OriGene siRNA: SPCS2
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    Clone
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    GenScript: all cDNA clones in your preferred vector: SPCS2 (NM_014752)
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPCS2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPCS2

    Additional cDNA sequence: 

    AK293128.1 CR542233.1 CR542243.1 

    24/25 DOTS entries (see all 25):

    DT.95316846  DT.100714192  DT.455684  DT.100714178  DT.95333722  DT.91767197  DT.100714216  DT.121422454 
    DT.97852195  DT.91825887  DT.121422493  DT.100857611  DT.91789272  DT.100045563  DT.305999  DT.100714193 
    DT.100851201  DT.120758619  DT.120758682  DT.121422428  DT.91767209  DT.91814713  DT.91767175  DT.91947861 

    24/525 AceView cDNA sequences (see all 525):

    BU688721 CR619893 BP338843 BQ020752 AI285055 AW026942 BC008063 AI888237 
    AA487265 AA854551 BM971075 CR616868 CD723188 BQ719525 BU631133 AI273154 
    BM664722 BE909026 BU156244 CD723184 BF477504 BP346859 AA960846 BM452455 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPCS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACAGTCTTGC
    SPCS2 Expression
    About this image
    See SPCS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPCS2

    SOURCE GeneReport for Unigene clusters: Hs.282700 Hs.719927
        SABiosciences Custom PCR Arrays for SPCS2

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPCS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SPCS2 gene from 9/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spcs21 , 5 signal peptidase complex subunit 2 homolog (S. cerevisiae)1, 5 90.86(n)1
    95.58(a)1
      7 (54.15 cM)5
    666241  NM_025668.31  NP_079944.11 
     998375695 
    chicken
    (Gallus gallus)
    Aves SPCS21 signal peptidase complex subunit 2 homolog (S. cerevisiae) 79.76(n)
    90.82(a)
      419056  XM_417247.3  XP_417247.2 
    lizard
    (Anolis carolinensis)
    Reptilia SPCS26
    --
    76(a)
    1 ↔ 1
    GL343489.1(432039-449616)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.103442 Transcribed sequence with moderate similarity to protein more 79.05(n)    BX714627.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa12g082 wufa12g08 78.18(n)   335065  57044709 
    fruit fly
    (Drosophila melanogaster)
    Insecta Spase251 Spase 25-subunit 51.71(n)
    41.08(a)
      32095  NM_132495.2  NP_572723.1 
    worm
    (Caenorhabditis elegans)
    Secernentea hpo-211 Protein HPO-21 47.95(n)
    42.11(a)
      176703  NM_067275.5  NP_499676.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G399606
    AT4G042006
    signal peptidase subunit-25
    26(a)
    22(a)
    many → 1
    many → 1
    2(16681474-16683640)
    4(2027165-2028978)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    signal peptidase complex subunit 2, putative, expr...
    signal peptidase complex subunit 2, putative, expr...
    28(a)
    27(a)
    many → 1
    many → 1
    4(22061554-22064598)
    2(21456307-21458651)


    ENSEMBL Gene Tree for SPCS2 (if available)
    TreeFam Gene Tree for SPCS2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPCS2 gene
    1 SIMAP similar gene for SPCS2 using alignment to 5 protein entries:     SPCS2_HUMAN (see all proteins):
    L3MBTL2

    SPCS2 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for SPCS2
    PGOHUM00000238612 PGOHUM00000247099 PGOHUM00000235497


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/531 NCBI SNPs in SPCS2 are shown (see all 531    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1816516231,2
    --74658319(+) TAATCC/TCAGCA 4 -- us2k1 int10--------
    rs1853832141,2
    --74658320(+) AATCCC/TAGCAC 4 -- int1 us2k10--------
    rs1448602491,2
    --74658422(+) AAAAAA/TTAGCC 4 -- int1 us2k10--------
    rs1475306921,2
    --74658513(+) AGGAGA/GCAGAG 4 -- us2k1 int10--------
    rs79316581,2
    C--74658621(+) GCAATG/ACTGTA 4 -- int1 us2k14Minor allele frequency- A:0.07WA CSA 122
    rs1402161421,2
    --74658722(+) CGGATC/TGCTTC 4 -- int1 us2k10--------
    rs1498699771,2
    --74658758(+) TGTTAC/TTGCTA 4 -- int1 us2k10--------
    rs1448989021,2
    --74658763(+) TTGCTA/GTTTAG 4 -- int1 us2k10--------
    rs1913738861,2
    --74659002(+) TGACCC/TCAGGT 4 -- int1 us2k10--------
    rs1176256901,2
    --74659065(+) GATAAT/CTATTT 4 -- int1 us2k11Minor allele frequency- C:0.01NA 120

    HapMap Linkage Disequilibrium report for SPCS2 (74660292 - 74690076 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SPCS2: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPCS2 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with SPCS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7788527)1, 2, 3 Nagase T....Kotani H. (1995)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    4. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. Identification of novel ATP13A2 interactors and their role in a-synuclein misfolding and toxicity. (PubMed id 22645275)1 Usenovic M....Krainc D. (2012)
    7. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9789 HGNC: 28962 AceView: KIAA0102 Ensembl:ENSG00000118363 euGenes: HUgn9789
    ECgene: SPCS2 Kegg: 9789 H-InvDB: SPCS2

    (According to HUGE)
    About This Section
    HUGE: KIAA0102

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPCS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SPCS2 gene:
    Search GeneIP for patents involving SPCS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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