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Aliases for SPCS2 Gene

Aliases for SPCS2 Gene

  • Signal Peptidase Complex Subunit 2 2 3 5
  • Signal Peptidase Complex Subunit 2 Homolog (S. Cerevisiae) 2
  • Microsomal Signal Peptidase 25 KDa Subunit 4
  • Signal Peptidase 25kDa Subunit 2
  • SPase 25 KDa Subunit 4
  • EC 3.4.-.- 4
  • KIAA0102 4
  • SPC25 4

External Ids for SPCS2 Gene

Previous GeneCards Identifiers for SPCS2 Gene

  • GC11P074339
  • GC11P074660
  • GC11P070957
  • GC11P074955
  • GC11P074978

Summaries for SPCS2 Gene

GeneCards Summary for SPCS2 Gene

SPCS2 (Signal Peptidase Complex Subunit 2) is a Protein Coding gene. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include peptidase activity.

UniProtKB/Swiss-Prot for SPCS2 Gene

  • Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPCS2 Gene

Genomics for SPCS2 Gene

Regulatory Elements for SPCS2 Gene

Promoters for SPCS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SPCS2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPCS2 Gene

Chromosome:
11
Start:
74,949,247 bp from pter
End:
74,979,031 bp from pter
Size:
29,785 bases
Orientation:
Plus strand

Genomic View for SPCS2 Gene

Genes around SPCS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPCS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPCS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPCS2 Gene

Proteins for SPCS2 Gene

  • Protein details for SPCS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15005-SPCS2_HUMAN
    Recommended name:
    Signal peptidase complex subunit 2
    Protein Accession:
    Q15005
    Secondary Accessions:
    • Q15507
    • Q3KQT0
    • Q641R4
    • Q6FG65
    • Q6IRX0
    • Q6P1P4
    • Q96HU9

    Protein attributes for SPCS2 Gene

    Size:
    226 amino acids
    Molecular mass:
    25003 Da
    Quaternary structure:
    • Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3.
    SequenceCaution:
    • Sequence=AAH08063.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH70276.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH82231.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA03492.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SPCS2 Gene

Proteomics data for SPCS2 Gene at MOPED

Post-translational modifications for SPCS2 Gene

  • Ubiquitination at Lys 191 and Lys 195
  • Modification sites at PhosphoSitePlus

Other Protein References for SPCS2 Gene

No data available for DME Specific Peptides for SPCS2 Gene

Domains & Families for SPCS2 Gene

Protein Domains for SPCS2 Gene

Suggested Antigen Peptide Sequences for SPCS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15005

UniProtKB/Swiss-Prot:

SPCS2_HUMAN :
  • Belongs to the SPCS2 family.
Family:
  • Belongs to the SPCS2 family.
genes like me logo Genes that share domains with SPCS2: view

No data available for Gene Families for SPCS2 Gene

Function for SPCS2 Gene

Molecular function for SPCS2 Gene

UniProtKB/Swiss-Prot Function:
Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.

Enzyme Numbers (IUBMB) for SPCS2 Gene

genes like me logo Genes that share phenotypes with SPCS2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SPCS2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPCS2 Gene

Localization for SPCS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPCS2 Gene

Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPCS2 Gene COMPARTMENTS Subcellular localization image for SPCS2 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
cytosol 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for SPCS2 Gene

Pathways & Interactions for SPCS2 Gene

genes like me logo Genes that share pathways with SPCS2: view

Pathways by source for SPCS2 Gene

Gene Ontology (GO) - Biological Process for SPCS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006465 signal peptide processing IEA,IBA --
GO:0044267 cellular protein metabolic process TAS --
GO:0045047 protein targeting to ER IBA --
genes like me logo Genes that share ontologies with SPCS2: view

No data available for SIGNOR curated interactions for SPCS2 Gene

Drugs & Compounds for SPCS2 Gene

No Compound Related Data Available

Transcripts for SPCS2 Gene

Unigene Clusters for SPCS2 Gene

Signal peptidase complex subunit 2 homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPCS2 Gene

No ASD Table

Relevant External Links for SPCS2 Gene

GeneLoc Exon Structure for
SPCS2
ECgene alternative splicing isoforms for
SPCS2

Expression for SPCS2 Gene

mRNA expression in normal human tissues for SPCS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SPCS2 Gene

This gene is overexpressed in Nasal epithelium (28.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPCS2 Gene



SOURCE GeneReport for Unigene cluster for SPCS2 Gene Hs.282700

genes like me logo Genes that share expression patterns with SPCS2: view

Protein tissue co-expression partners for SPCS2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SPCS2 Gene

Orthologs for SPCS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPCS2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SPCS2 35
  • 91.49 (n)
  • 98.96 (a)
SPCS2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPCS2 35
  • 92.48 (n)
  • 95.13 (a)
SPCS2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spcs2 35
  • 90.86 (n)
  • 95.58 (a)
Spcs2 16
Spcs2 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SPCS2 35
  • 99.71 (n)
  • 99.56 (a)
SPCS2 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spcs2 35
  • 89.82 (n)
  • 95.13 (a)
oppossum
(Monodelphis domestica)
Mammalia SPCS2 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPCS2 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPCS2 35
  • 79.76 (n)
  • 90.82 (a)
SPCS2 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPCS2 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10344 35
zebrafish
(Danio rerio)
Actinopterygii spcs2 35
  • 70.05 (n)
  • 72.08 (a)
wufa12g08 35
spcs2 36
  • 69 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9720 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011842 35
  • 54.88 (n)
  • 47.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta Spase25 35
  • 51.35 (n)
  • 41.08 (a)
Spase25 36
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea hpo-21 35
  • 48.15 (n)
  • 42.11 (a)
hpo-21 36
  • 38 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4833 36
  • 51 (a)
OneToOne
Species with no ortholog for SPCS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPCS2 Gene

ENSEMBL:
Gene Tree for SPCS2 (if available)
TreeFam:
Gene Tree for SPCS2 (if available)

Paralogs for SPCS2 Gene

(1) SIMAP similar genes for SPCS2 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for SPCS2 Gene

genes like me logo Genes that share paralogs with SPCS2: view

No data available for Paralogs for SPCS2 Gene

Variants for SPCS2 Gene

Sequence variations from dbSNP and Humsavar for SPCS2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs496698 -- 74,967,530(-) tcaag(C/T)gattc intron-variant
rs487226 -- 74,976,296(-) ACTAC(G/T)TTCTT intron-variant
rs519741 -- 74,958,349(-) ATTTC(A/C)ATCTA intron-variant
rs511021 -- 74,965,374(-) AATTT(G/T)ATTAT intron-variant
rs511890 -- 74,965,467(-) TCTCA(A/C)CCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPCS2 Gene

Variant ID Type Subtype PubMed ID
nsv832210 CNV Gain+Loss 17160897

Variation tolerance for SPCS2 Gene

Residual Variation Intolerance Score: 56.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPCS2 Gene

HapMap Linkage Disequilibrium report
SPCS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPCS2 Gene

Disorders for SPCS2 Gene

Relevant External Links for SPCS2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPCS2

No disorders were found for SPCS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPCS2 Gene

Publications for SPCS2 Gene

  1. Defective minor spliceosome mRNA processing results in isolated familial growth hormone deficiency. (PMID: 24480542) Argente J. … PAcrez-Jurado L.A. (EMBO Mol Med 2014) 2 3 67
  2. Membrane topology of the 12- and the 25-kDa subunits of the mammalian signal peptidase complex. (PMID: 8632014) Kalies K.-U. … Hartmann E. (J. Biol. Chem. 1996) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Identifying protein partners of CLN8, an ER-resident protein involved in neuronal ceroid lipofuscinosis. (PMID: 23142642) Passantino R. … Guarneri P. (Biochim. Biophys. Acta 2013) 3

Products for SPCS2 Gene

Sources for SPCS2 Gene

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