Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SPCS1 Gene

Aliases for SPCS1 Gene

  • Signal Peptidase Complex Subunit 1 2 3
  • Microsomal Signal Peptidase 12 KDa Subunit 3 4
  • SPase 12 KDa Subunit 3 4
  • SPC12 3 4
  • Signal Peptidase Complex Subunit 1 Homolog (S. Cerevisiae) 2
  • Signal Peptidase Complex Subunit 1 Homolog 3
  • Signal Peptidase Complex 12 KDa Subunit 2
  • Signal Peptidase 12kDa 3
  • EC 3.4.-.- 4
  • YJR010C-A 3
  • HSPC033 3
  • SPC1 3

External Ids for SPCS1 Gene

Previous GeneCards Identifiers for SPCS1 Gene

  • GC03P052716
  • GC03P052714
  • GC03P052738
  • GC03P052709

Summaries for SPCS1 Gene

GeneCards Summary for SPCS1 Gene

SPCS1 (Signal Peptidase Complex Subunit 1) is a Protein Coding gene. Diseases associated with SPCS1 include hepatitis c virus. Among its related pathways are Transport to the Golgi and subsequent modification and Gene Expression. GO annotations related to this gene include peptidase activity and ribosome binding.

UniProtKB/Swiss-Prot for SPCS1 Gene

  • Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPCS1 Gene

Genomics for SPCS1 Gene

Regulatory Elements for SPCS1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SPCS1 Gene

Chromosome:
3
Start:
52,704,955 bp from pter
End:
52,711,146 bp from pter
Size:
6,192 bases
Orientation:
Plus strand

Genomic View for SPCS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPCS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPCS1 Gene

Proteins for SPCS1 Gene

  • Protein details for SPCS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6A9-SPCS1_HUMAN
    Recommended name:
    Signal peptidase complex subunit 1
    Protein Accession:
    Q9Y6A9
    Secondary Accessions:
    • B3KNF8
    • Q9BVW1

    Protein attributes for SPCS1 Gene

    Size:
    102 amino acids
    Molecular mass:
    11805 Da
    Quaternary structure:
    • Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3.
    SequenceCaution:
    • Sequence=AAD40380.1; Type=Frameshift; Positions=2; Evidence={ECO:0000305};

neXtProt entry for SPCS1 Gene

Proteomics data for SPCS1 Gene at MOPED

Post-translational modifications for SPCS1 Gene

  • Ubiquitination at Lys 15
  • Modification sites at PhosphoSitePlus

Other Protein References for SPCS1 Gene

No data available for DME Specific Peptides for SPCS1 Gene

Domains & Families for SPCS1 Gene

Protein Domains for SPCS1 Gene

Suggested Antigen Peptide Sequences for SPCS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6A9

UniProtKB/Swiss-Prot:

SPCS1_HUMAN :
  • Belongs to the SPCS1 family.
Family:
  • Belongs to the SPCS1 family.
genes like me logo Genes that share domains with SPCS1: view

No data available for Gene Families for SPCS1 Gene

Function for SPCS1 Gene

Molecular function for SPCS1 Gene

UniProtKB/Swiss-Prot Function:
Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.

Enzyme Numbers (IUBMB) for SPCS1 Gene

Gene Ontology (GO) - Molecular Function for SPCS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 24009510
GO:0008233 peptidase activity IEA --
GO:0043022 ribosome binding --
genes like me logo Genes that share ontologies with SPCS1: view
genes like me logo Genes that share phenotypes with SPCS1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPCS1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for SPCS1 Gene

Localization for SPCS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPCS1 Gene

Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPCS1 Gene COMPARTMENTS Subcellular localization image for SPCS1 gene
Compartment Confidence
endoplasmic reticulum 5

Gene Ontology (GO) - Cellular Components for SPCS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005787 signal peptidase complex TAS 8632014
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016021 integral component of membrane --
GO:0030176 integral component of endoplasmic reticulum membrane IDA 8632014
genes like me logo Genes that share ontologies with SPCS1: view

Pathways & Interactions for SPCS1 Gene

genes like me logo Genes that share pathways with SPCS1: view

Pathways by source for SPCS1 Gene

Interacting Proteins for SPCS1 Gene

Gene Ontology (GO) - Biological Process for SPCS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS --
GO:0006465 signal peptide processing IBA --
GO:0006508 proteolysis TAS 8632014
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with SPCS1: view

No data available for SIGNOR curated interactions for SPCS1 Gene

Drugs & Compounds for SPCS1 Gene

(2) Additional Compounds for SPCS1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Biocytin
  • Biotinyl-L-lysine
  • epsilon-N-Biotinyl-L-lysine
  • H-Lys(biotinyl)-OH
  • N-epsilon-Biotin-L-lysine
  • N6-D-Biotinyl-L-lysine
576-19-2
N6,N6,N6-Trimethyl-L-lysine
  • (S)-2-amino-6-(trimethylammonio)hexanoate
  • (S)-2-amino-6-(trimethylammonio)hexanoic acid
  • delta-Trimethyllysine
  • epsilon-N-Trimethyl-L-lysine
  • epsilon-Trimethyl-L-lysine
19253-88-4
genes like me logo Genes that share compounds with SPCS1: view

Transcripts for SPCS1 Gene

mRNA/cDNA for SPCS1 Gene

Unigene Clusters for SPCS1 Gene

Signal peptidase complex subunit 1 homolog (S. cerevisiae):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPCS1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPCS1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d
SP1: - -
SP2: - -
SP3: - - -
SP4: -
SP5: -

Relevant External Links for SPCS1 Gene

GeneLoc Exon Structure for
SPCS1
ECgene alternative splicing isoforms for
SPCS1

Expression for SPCS1 Gene

mRNA expression in normal human tissues for SPCS1 Gene

Protein differential expression in normal tissues from HIPED for SPCS1 Gene

This gene is overexpressed in Placenta (7.0) and Testis (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPCS1 Gene



SOURCE GeneReport for Unigene cluster for SPCS1 Gene Hs.11125

genes like me logo Genes that share expression patterns with SPCS1: view

Protein tissue co-expression partners for SPCS1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SPCS1 Gene

Orthologs for SPCS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPCS1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SPCS1 35
  • 95.1 (n)
  • 96.08 (a)
-- 36
  • 73 (a)
OneToMany
SPCS1 36
  • 96 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SPCS1 35
  • 94.44 (n)
  • 96.08 (a)
SPCS1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spcs1 35
  • 79.17 (n)
  • 75.62 (a)
Spcs1 16
Spcs1 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SPCS1 35
  • 99.01 (n)
  • 98.22 (a)
SPCS1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spcs1 35
  • 92.81 (n)
  • 95.1 (a)
oppossum
(Monodelphis domestica)
Mammalia SPCS1 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 72 (a)
OneToMany
-- 36
  • 57 (a)
OneToMany
chicken
(Gallus gallus)
Aves SPCS1 35
  • 76.67 (n)
  • 78.18 (a)
SPCS1 36
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPCS1 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spcs1 35
  • 70.07 (n)
  • 75.51 (a)
Str.20031 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.25542 35
zebrafish
(Danio rerio)
Actinopterygii spcs1 35
  • 60.88 (n)
  • 63.27 (a)
spcs1 36
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Spase12 36
  • 43 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C34B2.10 36
  • 31 (a)
OneToOne
Species with no ortholog for SPCS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPCS1 Gene

ENSEMBL:
Gene Tree for SPCS1 (if available)
TreeFam:
Gene Tree for SPCS1 (if available)

Paralogs for SPCS1 Gene

Pseudogenes.org Pseudogenes for SPCS1 Gene

genes like me logo Genes that share paralogs with SPCS1: view

No data available for Paralogs for SPCS1 Gene

Variants for SPCS1 Gene

Sequence variations from dbSNP and Humsavar for SPCS1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs12486554 -- 52,708,521(+) TAATT(A/T)AAATT downstream-variant-500B
rs34017441 -- 52,708,397(+) GACTT(C/T)GTTTT downstream-variant-500B
rs139388579 -- 52,708,346(+) ATGGT(A/G)TGTAA downstream-variant-500B
rs145663312 -- 52,708,417(+) TGTCT(A/G)CCCAG downstream-variant-500B
rs145894928 -- 52,708,290(+) CACTT(-/GAG)GAGGC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SPCS1 Gene

Variant ID Type Subtype PubMed ID
nsv508219 CNV Loss 20534489

Variation tolerance for SPCS1 Gene

Residual Variation Intolerance Score: 62.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.88; 83.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPCS1 Gene

HapMap Linkage Disequilibrium report
SPCS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPCS1 Gene

Disorders for SPCS1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SPCS1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hepatitis c virus
  • hepatitic c virus
- elite association
Search SPCS1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SPCS1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPCS1
genes like me logo Genes that share disorders with SPCS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPCS1 Gene

Publications for SPCS1 Gene

  1. Signal peptidase complex subunit 1 participates in the assembly of hepatitis C virus through an interaction with E2 and NS2. (PMID: 24009510) Suzuki R. … Suzuki T. (PLoS Pathog. 2013) 2 67
  2. Membrane topology of the 12- and the 25-kDa subunits of the mammalian signal peptidase complex. (PMID: 8632014) Kalies K.-U. … Hartmann E. (J. Biol. Chem. 1996) 2 67
  3. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67

Products for SPCS1 Gene

Sources for SPCS1 Gene

Back to Top

Content