Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SPCS1 Gene

Aliases for SPCS1 Gene

  • Signal Peptidase Complex Subunit 1 2 3 5
  • Microsomal Signal Peptidase 12 KDa Subunit 3 4
  • Signal Peptidase Complex 12 KDa Subunit 2 3
  • SPase 12 KDa Subunit 3 4
  • SPC12 3 4
  • Signal Peptidase Complex Subunit 1 Homolog (S. Cerevisiae) 2
  • Signal Peptidase Complex Subunit 1 Homolog 3
  • Signal Peptidase 12kDa 3
  • EC 3.4.-.- 4
  • YJR010C-A 3
  • HSPC033 3
  • SPC1 3

External Ids for SPCS1 Gene

Previous GeneCards Identifiers for SPCS1 Gene

  • GC03P052716
  • GC03P052714
  • GC03P052738
  • GC03P052709
  • GC03P052719
  • GC03P052736
  • GC03P052743

Summaries for SPCS1 Gene

GeneCards Summary for SPCS1 Gene

SPCS1 (Signal Peptidase Complex Subunit 1) is a Protein Coding gene. Among its related pathways are Incretin synthesis, secretion, and inactivation and Peptide hormone metabolism. GO annotations related to this gene include peptidase activity and ribosome binding.

UniProtKB/Swiss-Prot for SPCS1 Gene

  • Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPCS1 Gene

Genomics for SPCS1 Gene

Regulatory Elements for SPCS1 Gene

Enhancers for SPCS1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F052703 0.2 ENCODE 0.8 +0.8 782 4.6 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 PBRM1 RFT1 RRP9 GLT8D1 SPCS1
GH03F052696 0.2 ENCODE 0.4 -7.8 -7754 1.6 SRF PKNOX1 TBL1XR1 TBX21 RAD51 POLR2A PBX2 STAT3 NBN SPI1 PBRM1 ITIH1 ITIH3 GNL3 SNORD69 SPCS1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SPCS1 on UCSC Golden Path with GeneCards custom track

Promoters for SPCS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001364314 945 3001 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for SPCS1 Gene

Chromosome:
3
Start:
52,704,955 bp from pter
End:
52,711,146 bp from pter
Size:
6,192 bases
Orientation:
Plus strand

Genomic View for SPCS1 Gene

Genes around SPCS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPCS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPCS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPCS1 Gene

Proteins for SPCS1 Gene

  • Protein details for SPCS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6A9-SPCS1_HUMAN
    Recommended name:
    Signal peptidase complex subunit 1
    Protein Accession:
    Q9Y6A9
    Secondary Accessions:
    • B3KNF8
    • Q9BVW1

    Protein attributes for SPCS1 Gene

    Size:
    102 amino acids
    Molecular mass:
    11805 Da
    Quaternary structure:
    • Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3.
    SequenceCaution:
    • Sequence=AAD40380.1; Type=Frameshift; Positions=2; Evidence={ECO:0000305};

neXtProt entry for SPCS1 Gene

Post-translational modifications for SPCS1 Gene

  • Ubiquitination at Lys 15
  • Modification sites at PhosphoSitePlus

Other Protein References for SPCS1 Gene

No data available for DME Specific Peptides for SPCS1 Gene

Domains & Families for SPCS1 Gene

Protein Domains for SPCS1 Gene

Suggested Antigen Peptide Sequences for SPCS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6A9

UniProtKB/Swiss-Prot:

SPCS1_HUMAN :
  • Belongs to the SPCS1 family.
Family:
  • Belongs to the SPCS1 family.
genes like me logo Genes that share domains with SPCS1: view

No data available for Gene Families for SPCS1 Gene

Function for SPCS1 Gene

Molecular function for SPCS1 Gene

UniProtKB/Swiss-Prot Function:
Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.

Enzyme Numbers (IUBMB) for SPCS1 Gene

Gene Ontology (GO) - Molecular Function for SPCS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 24009510
GO:0008233 peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0043022 ribosome binding IEA --
genes like me logo Genes that share ontologies with SPCS1: view
genes like me logo Genes that share phenotypes with SPCS1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPCS1 Gene

Localization for SPCS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPCS1 Gene

Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPCS1 Gene COMPARTMENTS Subcellular localization image for SPCS1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SPCS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005787 signal peptidase complex IEA,TAS 8632014
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SPCS1: view

Pathways & Interactions for SPCS1 Gene

genes like me logo Genes that share pathways with SPCS1: view

Gene Ontology (GO) - Biological Process for SPCS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006465 signal peptide processing IEA,IBA --
GO:0006508 proteolysis TAS 8632014
GO:0045047 protein targeting to ER IBA --
genes like me logo Genes that share ontologies with SPCS1: view

No data available for SIGNOR curated interactions for SPCS1 Gene

Drugs & Compounds for SPCS1 Gene

(2) Additional Compounds for SPCS1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Biocytin
  • Biotinyl-L-lysine
  • epsilon-N-Biotinyl-L-lysine
  • H-Lys(biotinyl)-OH
  • N-epsilon-Biotin-L-lysine
  • N6-D-Biotinyl-L-lysine
576-19-2
N6,N6,N6-Trimethyl-L-lysine
  • (S)-2-amino-6-(trimethylammonio)hexanoate
  • (S)-2-amino-6-(trimethylammonio)hexanoic acid
  • delta-Trimethyllysine
  • epsilon-N-Trimethyl-L-lysine
  • epsilon-Trimethyl-L-lysine
19253-88-4
genes like me logo Genes that share compounds with SPCS1: view

Transcripts for SPCS1 Gene

Unigene Clusters for SPCS1 Gene

Signal peptidase complex subunit 1 homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPCS1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d
SP1: - -
SP2: - -
SP3: - - -
SP4: -
SP5: -

Relevant External Links for SPCS1 Gene

GeneLoc Exon Structure for
SPCS1
ECgene alternative splicing isoforms for
SPCS1

Expression for SPCS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPCS1 Gene

Protein differential expression in normal tissues from HIPED for SPCS1 Gene

This gene is overexpressed in Placenta (7.0) and Testis (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPCS1 Gene



Protein tissue co-expression partners for SPCS1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SPCS1 Gene:

SPCS1

SOURCE GeneReport for Unigene cluster for SPCS1 Gene:

Hs.11125
genes like me logo Genes that share expression patterns with SPCS1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SPCS1 Gene

Orthologs for SPCS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPCS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPCS1 34 35
  • 99.01 (n)
cow
(Bos Taurus)
Mammalia SPCS1 34 35
  • 95.1 (n)
-- 35
  • 73 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SPCS1 34 35
  • 94.44 (n)
rat
(Rattus norvegicus)
Mammalia Spcs1 34
  • 92.81 (n)
mouse
(Mus musculus)
Mammalia Spcs1 34 16 35
  • 79.17 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 72 (a)
OneToMany
-- 35
  • 57 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia SPCS1 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPCS1 34 35
  • 76.67 (n)
lizard
(Anolis carolinensis)
Reptilia SPCS1 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spcs1 34
  • 70.07 (n)
Str.20031 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.25542 34
zebrafish
(Danio rerio)
Actinopterygii spcs1 34 35
  • 60.88 (n)
fruit fly
(Drosophila melanogaster)
Insecta Spase12 35
  • 43 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C34B2.10 35
  • 31 (a)
OneToOne
Species where no ortholog for SPCS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPCS1 Gene

ENSEMBL:
Gene Tree for SPCS1 (if available)
TreeFam:
Gene Tree for SPCS1 (if available)

Paralogs for SPCS1 Gene

Pseudogenes.org Pseudogenes for SPCS1 Gene

genes like me logo Genes that share paralogs with SPCS1: view

No data available for Paralogs for SPCS1 Gene

Variants for SPCS1 Gene

Sequence variations from dbSNP and Humsavar for SPCS1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs112273172 -- 52,704,573(+) AGGAA(G/T)AAACT intron-variant, upstream-variant-2KB
rs113096701 -- 52,706,011(+) GCGGG(C/T)AGCAC utr-variant-5-prime
rs116426983 -- 52,706,873(+) TTTTC(A/G)TGTTT upstream-variant-2KB, reference, synonymous-codon
rs12486554 -- 52,708,521(+) TAATT(A/T)AAATT intron-variant, utr-variant-3-prime
rs12635140 -- 52,704,149(+) AAAAC(C/T)GTGGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SPCS1 Gene

Variant ID Type Subtype PubMed ID
nsv508219 CNV deletion 20534489

Variation tolerance for SPCS1 Gene

Residual Variation Intolerance Score: 62.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.88; 83.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPCS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPCS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPCS1 Gene

Disorders for SPCS1 Gene

Relevant External Links for SPCS1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPCS1

No disorders were found for SPCS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPCS1 Gene

Publications for SPCS1 Gene

  1. Membrane topology of the 12- and the 25-kDa subunits of the mammalian signal peptidase complex. (PMID: 8632014) Kalies K.-U. … Hartmann E. (J. Biol. Chem. 1996) 2 3 4 64
  2. Signal peptidase complex subunit 1 participates in the assembly of hepatitis C virus through an interaction with E2 and NS2. (PMID: 24009510) Suzuki R. … Suzuki T. (PLoS Pathog. 2013) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4 64

Products for SPCS1 Gene

Sources for SPCS1 Gene

Content
Loading form....