Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPCS1 Gene

protein-coding   GIFtS: 49
GCID: GC03P052738

signal peptidase complex subunit 1 homolog (S. cerevisiae)

 Explore 1 disease affiliated with
SPCS1 via our new
 Human Malady Compendium 
Biological research products
for SPCS1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Signal Peptidase Complex Subunit 1 Homolog (S. Cerevisiae)1 2     SPase 12 KDa Subunit2 3
SPC121 2 3     HSPC0331
SPC11 2     Signal Peptidase 12kDa2
YJR010C-A1 2     Signal Peptidase Complex Subunit 12
Microsomal Signal Peptidase 12 KDa Subunit2 3     EC 3.4.-.-3

External Ids:    HGNC: 234011   Entrez Gene: 289722   Ensembl: ENSG000001149027   OMIM: 6103585   UniProtKB: Q9Y6A93   

Export aliases for SPCS1 gene to outside databases

Previous GC identifers: GC03P052716 GC03P052714


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SPCS1_HUMAN, Q9Y6A9
Function: Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as
they are translocated into the lumen of the endoplasmic reticulum (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPCS1 gene promoter:
         RORalpha1   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPCS1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SPCS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPCS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.1   Ensembl cytogenetic band:  3p21.1   HGNC cytogenetic band: 3p21.31

SPCS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPCS1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P052738:  view genomic region     (about GC identifiers)

Start:
52,738,971 bp from pter      End:
52,742,198 bp from pter
Size:
3,228 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SPCS1_HUMAN, Q9Y6A9 (See protein sequence)
Recommended Name: Signal peptidase complex subunit 1  
Size: 169 amino acids; 18298 Da
Subunit: Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1,
SPCS2 and SPCS3 (By similarity)
Subcellular location: Microsome membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum membrane;
Multi-pass membrane protein (By similarity)
Caution: It is uncertain whether Met-1 or Met-68 is the initiator
Sequence caution: Sequence=AAD40380.1; Type=Frameshift; Positions=31, 70; Sequence=AAH00884.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=AAL31361.1; Type=Erroneous initiation; Note=Translation
N-terminally extended; Sequence=BAG51320.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B3KNF8 Q9BVW1

Explore the universe of human proteins at neXtProt for SPCS1: NX_Q9Y6A9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y6A9

  • SPCS1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_054760.3  
    ENSEMBL proteins: 
     ENSP00000391610   ENSP00000233025  
    Reactome Protein details: Q9Y6A9
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: SPCS1
    OriGene Protein Over-expression Lysate: SPCS1
    OriGene Custom Protein Services for SPCS1 
    GenScript Custom Purified and Recombinant Proteins Services for SPCS1
    Novus Biologicals SPCS1 Protein
    Novus Biologicals SPCS1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SPCS1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005787signal peptidase complex TAS8632014
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005792microsome ----
    GO:0016021integral to membrane ----
    GO:0030176integral to endoplasmic reticulum membrane IDA8632014


    SPCS1 for ontologies           About GeneDecksing



    SPCS1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SPCS1 
    GenScript Custom Superior Antibodies Services for SPCS1
    Novus Biologicals SPCS1 Antibody
    Search for Antibodies for SPCS1 at Abcam  
    Uscn Antibodies for SPCS1
    ThermoFisher Antibody for SPCS1

    Assay Products for SPCS1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SPCS1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SPCS1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SPCS1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR009542 SPC12

    Graphical View of Domain Structure for InterPro Entry Q9Y6A9

    ProtoNet protein and cluster: Q9Y6A9

    1 Blocks protein family: IPB009542 Microsomal signal peptidase 12 kDa subunit

    UniProtKB/Swiss-Prot: SPCS1_HUMAN, Q9Y6A9
    Similarity: Belongs to the SPCS1 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: SPCS1_HUMAN, Q9Y6A9
    Function: Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as
    they are translocated into the lumen of the endoplasmic reticulum (By similarity)

    Enzyme Number (IUBMB): EC 3.4.-.-1

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: SPCS1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPCS1
    1 QIAGEN miScript miRNA Assays for microRNA that regulate SPCS1:
    hsa-miR-551b*
    SwitchGear 3'UTR luciferase reporter plasmidSPCS1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPCS1 (see all 7)
    OriGene shRNA RFP: SPCS1
    OriGene siRNA: SPCS1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPCS1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SPCS1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPCS1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPCS1 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SPCS1 (NM_014041)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPCS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPCS1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SPCS1
    Search LifeMap BioReagents cell lines for SPCS1

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPCS1

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0008233peptidase activity IEA--
    GO:0043022ribosome binding IEA--


    SPCS1 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
    Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)1.00
    Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)0.78
    Incretin Synthesis, Secretion, and Inactivation0.89
    Synthesis, Secretion, and Deacylation of Ghrelin0.46
    2Synthesis of PB1-F2
    SRP-dependent cotranslational protein targeting to membrane0.77
    Translation0.57
    3Protein export
    Protein export1.00
    4Generic Transcription Pathway
    Gene Expression0.46
    5Insulin Processing
    Peptide hormone metabolism0.39

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/9        Reactome Pathways for SPCS1 (see all 9)
        Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
    Incretin Synthesis, Secretion, and Inactivation
    Translation
    SRP-dependent cotranslational protein targeting to membrane
    Synthesis, Secretion, and Deacylation of Ghrelin


    1         Kegg Pathway  (Kegg details for SPCS1):
        Protein export


    SPCS1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPCS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/83 Interacting proteins for SPCS1 (ENSP000002330254) via UniProtKB, MINT, STRING, and/or I2D (see all 83)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDOSTENSP000003641884STRING: ENSP00000364188
    FAUENSP000002792594STRING: ENSP00000279259
    RPL11ENSP000003636764STRING: ENSP00000363676
    RPL12ENSP000003547394STRING: ENSP00000354739
    RPL15ENSP000003093344STRING: ENSP00000309334
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006412translation TAS--
    GO:0006465signal peptide processing IEA--
    GO:0006508proteolysis TAS8632014
    GO:0006614SRP-dependent cotranslational protein targeting to membrane TAS--


    SPCS1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPCS1

    2 HMDB Compounds for SPCS1    About this table
    CompoundSynonyms CAS #PubMed Ids
    BiocytinBiotinyl-L-lysine (see all 7)576-19-2--
    N6,N6,N6-Trimethyl-L-lysine(S)-2-amino-6-(trimethylammonio)hexanoate (see all 9)19253-88-4--
    Search CenterWatch for drugs/clinical trials and news about SPCS1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SPCS1 gene: 
    NM_014041.3  

    Unigene Cluster for SPCS1:

    Signal peptidase complex subunit 1 homolog (S. cerevisiae)
    Hs.11125  [show with all ESTs]
    Unigene Representative Sequence: CA453810
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000423431 ENST00000233025(uc011bei.2) ENST00000448693 ENST00000474945


    miRNA
    Products:
         
    OriGene 3'-UTR Clone: SPCS1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPCS1
    1 QIAGEN miScript miRNA Assays for microRNA that regulate SPCS1:
    hsa-miR-551b*
    SwitchGear 3'UTR luciferase reporter plasmidSPCS1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPCS1 (see all 7)
    OriGene shRNA RFP: SPCS1
    OriGene siRNA: SPCS1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPCS1
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPCS1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPCS1 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SPCS1 (NM_014041)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPCS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPCS1 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPCS1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPCS1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPCS1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPCS1

    Additional cDNA sequence: 

    AF092138.1 AK027426.1 BC000884.1 L38852.1 

    16 DOTS entries:

    DT.95274784  DT.219136  DT.120869860  DT.91780589  DT.92441637  DT.443992  DT.100794035  DT.40235990 
    DT.101986498  DT.120869846  DT.40211457  DT.120869807  DT.100033421  DT.120869876  DT.121645429  DT.92024478 

    24/71 AceView cDNA sequences (see all 71):

    CA416517 AI308924 AI346138 AI924167 BU681260 BQ574063 BM314483 BM975120 
    AA701513 BU730766 BE048049 AI955820 AI015619 BM985091 BU161514 AI446529 
    BG178384 BU172271 AW188107 BM474952 CA309210 BQ682789 AA885121 AA946607 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SPCS1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d
    SP1:              -                 -                           
    SP2:              -                 -                           
    SP3:              -           -     -                           
    SP4:              -                                             
    SP5:                                -                           


    ECgene alternative splicing isoforms for SPCS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPCS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATTCAGCACC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See SPCS1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPCS1

    SOURCE GeneReport for Unigene cluster: Hs.11125
        SABiosciences Custom PCR Arrays for SPCS1
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPCS1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPCS1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPCS1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPCS1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPCS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SPCS1 gene from 9/27 species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spcs11 , 5 signal peptidase complex subunit 1 homolog (S. cerevisiae)1, 5 75.57(n)1
    73.91(a)1
      14 (19.09 cM)5
    690191  NM_026911.31  NP_081187.21 
     309998265 
    chicken
    (Gallus gallus)
    Aves SPCS11 signal peptidase complex subunit 1 homolog (S. cerevisiae) 76.67(n)
    78.18(a)
      415899  NM_001171644.1  NP_001165115.1 
    lizard
    (Anolis carolinensis)
    Reptilia SPCS16
    --
    72(a)
    1 ↔ 1
    2(154900388-154903119)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.255422 Xenopus laevis transcribed sequence with moderate similarity more 70.53(n)    48053115 
    zebrafish
    (Danio rerio)
    Actinopterygii BI473004.12   -- 74.2(n)    BI473004.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Spase126
    Spase 12-subunit
    39(a)
    1 ↔ 1
    3R(25316266-25316872)
    worm
    (Caenorhabditis elegans)
    Secernentea C34B2.106
    Probable signal peptidase complex subunit 1
    30(a)
    1 ↔ 1
    I(10682460-10683139)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G224256
    AT4G400426
    signal peptidase subunit-12
    34(a)
    34(a)
    many → 1
    many → 1
    2(9514936-9515535)
    4(18559103-18559844)
    rice
    (Oryza sativa)
    Liliopsida --
    signal peptidase complex subunit 1, putative
    33(a)
    1 ↔ 1
    12(14500672-14501244)


    ENSEMBL Gene Tree for SPCS1 (if available)
    TreeFam Gene Tree for SPCS1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPCS1 gene

    SPCS1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SPCS1
    PGOHUM00000259604 PGOHUM00000259852


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/70 NCBI SNPs in SPCS1 are shown (see all 70    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1476695581,2
    --52737901(+) ATCTGG/TTTAGA 4 -- us2k1 int10--------
    rs1894322341,2
    --52737968(+) TTTTCA/GTAAGA 4 -- us2k1 int10--------
    rs781090191,2
    C,F,--52738093(+) GTAAAA/CTGGCA 4 -- int1 us2k11Minor allele frequency- C:0.02WA 118
    rs1423834921,2
    --52738116(+) CCCTCC/TGTATC 4 -- us2k1 int10--------
    rs126351401,2
    C,F,A,H,--52738165(+) AAAACT/CGTGGA 4 -- us2k1 int128Minor allele frequency- C:0.48NS EA NA WA 2778
    rs1454527901,2
    --52738173(+) GGATA-/CAAAAA 4 -- us2k1 int10--------
    rs1813476541,2
    --52738389(+) ACAATC/TCCTTG 4 -- us2k1 int10--------
    rs130854421,2
    H--52738476(+) cctcaA/Gaaaaa 4 -- us2k1 int1 trp34Minor allele frequency- G:0.00NS EA 406
    rs1890743311,2
    C--52738500(+) AAAAAA/GACCAC 4 -- us2k1 int10--------
    rs68091651,2
    C--52738654(+) AAAGTG/TTCAAA 4 -- us2k1 int10--------

    HapMap Linkage Disequilibrium report for SPCS1 (52738971 - 52742198 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SPCS1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPCS1
    DNA2.0 Custom Variant and Variant Library Synthesis for SPCS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SPCS1 for disorders           About GeneDecksing

    OMIM gene information: 610358    OMIM disorders: --

    1 disease for SPCS1:    About MalaCards
    malaria


    Export disorders for SPCS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPCS1 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with SPCS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Membrane topology of the 12- and the 25-kDa subunits of the mammalian signal peptidase complex. (PubMed id 8632014)1, 2, 3 Kalies K.-U. and Hartmann E. (1996)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Large-scale genome-wide association analysis of bipol ar disorder identifies a new susceptibility locus near ODZ4. (PubMed id 21926972)1 Sklar P....Purcell S.M. (2011)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 28972 HGNC: 23401 AceView: SPC12 Ensembl:ENSG00000114902 euGenes: HUgn28972
    ECgene: SPCS1 Kegg: 28972 H-InvDB: SPCS1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPCS1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SPCS1 gene:
    Search GeneIP for patents involving SPCS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for SPCS1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPCS1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPCS1  
     OriGene Protein Over-expression Lysate for SPCS1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for SPCS1   OriGene 3'-UTR Clone for SPCS1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPCS1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPCS1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for SPCS1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SPCS1   OriGene Custom Protein Services for SPCS1  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPCS1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPCS1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPCS1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPCS1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPCS1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPCS1
     GenScript Custom Purified and Recombinant Proteins Services for SPCS1 GenScript cDNA clones with any tag delivered in your preferred vector for SPCS1
     GenScript Custom Assay Services for SPCS1 GenScript Custom Superior Antibodies Services for SPCS1
     GenScript Custom overexpressing Cell Line Services for SPCS1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SPCS1 promoter
     Search Chromatin IP Primers for SPCS1
     RT2 qPCR Primer Assay in human, mouse, rat SPCS1
     Search GNC Networks for SPCS1
     SABiosciences Custom PCR Arrays for SPCS1
     Search Tocris compounds for SPCS1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SPCS1 antibodies
     SPCS1 proteins
     SPCS1 lysates
     Search for Antibodies for SPCS1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SPCS1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     SPCS1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SPCS1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPCS1
     SwitchGear 3'UTR luciferase reporter plasmids for SPCS1
     SwitchGear Promoter luciferase reporter plasmids for SPCS1
     ThermoFisher Antibody for SPCS1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPCS1
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SPCS1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4