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SPC25 Gene

protein-coding   GIFtS: 49
GCID: GC02M169690

SPC25, NDC80 Kinetochore Complex Component

(Previous names: spindle pole body component 25 homolog (S. cerevisiae),...)
(Previous symbol: SPBC25)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SPC25, NDC80 Kinetochore Complex Component1 2     2600017H08Rik2
SPBC251 2 3     Kinetochore Protein Spc252
hSpc252 3     SPC25, NDC80 Kinetochore Complex Component, Homolog2
SPC25, NDC80 Kinetochore Complex Component, Homolog (S. Cerevisiae)1     Spindle Pole Body Component 25 Homolog2
Spindle Pole Body Component 25 Homolog (S. Cerevisiae)1     

External Ids:    HGNC: 240311   Entrez Gene: 574052   Ensembl: ENSG000001522537   OMIM: 6093955   UniProtKB: Q9HBM13   

Export aliases for SPC25 gene to outside databases

Previous GC identifers: GC02M169436 GC02M161623


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SPC25 Gene:
This gene encodes a protein that may be involved in kinetochore-microtubule interaction and spindle checkpoint
activity. (provided by RefSeq, Jul 2008)

GeneCards Summary for SPC25 Gene:
SPC25 (SPC25, NDC80 kinetochore complex component) is a protein-coding gene.

UniProtKB/Swiss-Prot: SPC25_HUMAN, Q9HBM1
Function: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for
chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization
of stable microtubule binding sites in the outer plate of the kinetochore




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPC25 gene promoter:
         NF-YA   NF-YC   CBF-C   NF-YB   CBF-B   CBF-A   CP1C   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPC25 promoter sequence
   Search Chromatin IP Primers for SPC25

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPC25


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

SPC25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPC25 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M169690:  view genomic region     (about GC identifiers)

Start:
169,690,642 bp from pter      End:
169,769,881 bp from pter
Size:
79,240 bases      Orientation:
minus strand

1 alternative location:
Chr2-,NW_003315909 57,520-77,061     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SPC25_HUMAN, Q9HBM1 (See protein sequence)
Recommended Name: Kinetochore protein Spc25  
Size: 224 amino acids; 26153 Da
Subunit: Component of the NDC80 complex, which consists of NDC80/HEC1, CDCA1, SPBC24 and SPBC25. The NDC80 complex
is formed by two subcomplexes composed of NDC80/HEC1-CDCA1 and SPBC24-SPBC25. Each subcomplex is formed by
parallel interactions through the coiled-coil domains of individual subunits. Formation of a tetrameric complex
is mediated by interactions between the C-terminal regions of both subunits of the NDC80/HEC1-CDCA1 subcomplex
and the N-terminal regions of both subunits of the SPBC24-SPBC25 complex. The tetrameric NDC80 complex has an
elongated rod-like structure with globular domains at either end
2 PDB 3D structures from and Proteopedia for SPC25:
2VE7 (3D)        3IZ0 (3D)    
Secondary accessions: A8K4X8 D3DPC0

Explore the universe of human proteins at neXtProt for SPC25: NX_Q9HBM1

Explore proteomics data for SPC25 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys19
  • Modification sites at PhosphoSitePlus

  • See SPC25 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065726.1  
    ENSEMBL proteins: 
     ENSP00000282074   ENSP00000393322  
    Reactome Protein details: Q9HBM1

    SPC25 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SPC25

     
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    antibodies-online proteins for SPC25 (6 products) 

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR013255 Spc25

    Graphical View of Domain Structure for InterPro Entry Q9HBM1

    ProtoNet protein and cluster: Q9HBM1

    UniProtKB/Swiss-Prot: SPC25_HUMAN, Q9HBM1
    Similarity: Belongs to the SPC25 family


    Find genes that share domains with SPC25           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPC25_HUMAN, Q9HBM1
    Function: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for
    chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization
    of stable microtubule binding sites in the outer plate of the kinetochore

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14699129
         
    Find genes that share ontologies with SPC25           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for SPC25:
     Cell cycle / mitosis defect  Cell division defect  Increased G2M DNA content  Increased number of mitotic ce 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SPC25

    miRNA
    Products:
        
    miRTarBase miRNAs that target SPC25:
    hsa-mir-26b-5p (MIRT030123), hsa-mir-193b-3p (MIRT016558)

    Block miRNA regulation of human, mouse, rat SPC25 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SPC25
    SwitchGear 3'UTR luciferase reporter plasmidSPC25 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPC25_HUMAN, Q9HBM1: Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late
    prophase to anaphase. Localizes specifically to the outer plate of the kinetochore
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000777condensed chromosome kinetochore IDA14699129
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--
    GO:0031262Ndc80 complex IDA14699129

    Find genes that share ontologies with SPC25           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SPC25 About    
    See pathways by source

    SuperPathContained pathways About
    1Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    3Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92


    Find genes that share SuperPaths with SPC25           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3 Reactome Pathways for SPC25
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Separation of Sister Chromatids


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPC25
    Interactions:

        GeneGlobe Interaction Network for SPC25

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SPC25 (Q9HBM11, 3 ENSP000002820744) via UniProtKB, MINT, STRING, and/or I2D (see all 73)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NDC80O147771, 3, ENSP000002615974EBI-999909,EBI-715849 I2D: score=5 STRING: ENSP00000261597
    SPC24Q8NBT21, 3, ENSP000003971314EBI-999909,EBI-999900 I2D: score=1 STRING: ENSP00000397131
    MIS12Q9H0813, ENSP000003705574I2D: score=2 STRING: ENSP00000370557
    ZWINTO952293, ENSP000003630554I2D: score=2 STRING: ENSP00000363055
    BUB1O436833, ENSP000003025304I2D: score=2 STRING: ENSP00000302530
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0007052mitotic spindle organization IMP14699129
    GO:0007059chromosome segregation IMP14699129
    GO:0007067mitosis IEA--

    Find genes that share ontologies with SPC25           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPC25



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SPC25 gene: 
    NM_020675.3  

    Unigene Cluster for SPC25:

    SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
    Hs.421956  [show with all ESTs]
    Unigene Representative Sequence: BC022255
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000479309 ENST00000282074(uc002uel.3) ENST00000451987 ENST00000472216

    miRNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPC25
      QuantiTect SYBR Green Assays in human, mouse, rat SPC25
      QuantiFast Probe-based Assays in human, mouse, rat SPC25

    Additional mRNA sequence: 

    AF225416.1 AK291093.1 AY456388.1 BC022255.1 CR457197.1 

    3 DOTS entries:

    DT.113739  DT.75117421  DT.95160225 

    Selected AceView cDNA sequences (see all 84):

    BG236186 BQ441900 CR610550 CR457197 AY456388 AA707088 BI093154 AI990567 
    AA761074 AA701565 BX105588 CK825801 CR590224 AA287517 NM_020675 AA286680 
    AF225416 BC022255 BU928536 BI912854 AW510998 CD653385 AA701576 AA628540 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SPC25 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SPC25 Expression
    About this image


    SPC25 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Choroid Plexus Progenitor Cells Choroid Plexus
     
     Heart (Cardiovascular System)
             Cardiac Fibroblasts Myocardium
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
    SPC25 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPC25 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.421956
        Custom PCR Arrays for SPC25
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SPC25 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spc251 , 5 SPC25, NDC80 kinetochore complex component, homolog more1, 5 80.95(n)1
    74.55(a)1
      2 (39.64 cM)5
    664421  NM_001199123.11  NP_001186052.11 
     691938955 
    chicken
    (Gallus gallus)
    Aves SPC251 SPC25, NDC80 kinetochore complex component, homolog more 62.16(n)
    47.75(a)
      424172  NM_001277857.1  NP_001264786.1 
    lizard
    (Anolis carolinensis)
    Reptilia SPC256
    SPC25, NDC80 kinetochore complex component
    29(a)
    1 ↔ 1
    1(245297868-245307284)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia spc251 SPC25, NDC80 kinetochore complex component 57.1(n)
    45.45(a)
      448571  NM_001005041.1  NP_001005041.1 
    zebrafish
    (Danio rerio)
    Actinopterygii spc251 SPC25, NDC80 kinetochore complex component, homolog more 52.44(n)
    38.01(a)
      100144563  NM_001123057.1  NP_001116529.1 


    ENSEMBL Gene Tree for SPC25 (if available)
    TreeFam Gene Tree for SPC25 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SPC25 (see all 499)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1865432111,2
    C--169727075(+) CACTTC/GTCAAA 1 -- ds50010--------
    rs1921511881,2
    --169727395(+) TCATGC/TTGCTA 1 -- ds50010--------
    rs1431489121,2
    C--169727582(+) TGAAGA/CTGGAA 1 -- ut310--------
    rs1113722831,2
    C--169727610(+) ACTATT/CGAAAG 1 -- ut312Minor allele frequency- C:0.33CSA 3
    rs67349231,2
    C,F,A,H--169727730(+) gggagC/Ggggga 1 -- ut31 trp35Minor allele frequency- G:0.44NA CSA 9
    rs621767811,2
    C,F--169727863(+) GTATAG/ATAATA 1 -- ut311Minor allele frequency- A:0.50NA 2
    rs114205141,2
    C--169727877(+) ACAAGA/-AAAAA 1 -- ut31 trp31Minor allele frequency- -:0.00CSA 2
    rs615988341,2
    C--169727880(+) AAAAGA/-AGATA 1 -- ut311Minor allele frequency- -:0.00NA 2
    rs1867845841,2
    C--169727916(+) TAAACC/TGTTTT 1 -- ut310--------
    rs1508485051,2
    C--169727953(+) TAAACC/TGTGGC 2 T syn11Minor allele frequency- T:0.00NA 4536

    HapMap Linkage Disequilibrium report for SPC25 (169690642 - 169769881 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SPC25:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv227CNV Insertion15895083
    esv999271CNV Insertion20482838
    nsv3023CNV Insertion18451855
    nsv875381CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SPC25
    DNA2.0 Custom Variant and Variant Library Synthesis for SPC25

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609395    OMIM disorders: --


    Find genes that share disorders with SPC25           About GenesLikeMe


    Export disorders for SPC25 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SPC25 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with SPC25)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Architecture of the human Ndc80-Hec1 complex, a critical constituent of the outer kinetochore. (PubMed id 15961401)1, 2 Ciferri C.... Musacchio A. (J. Biol. Chem. 2005)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    3. Identification of two novel components of the human NDC80 kinetochore complex. (PubMed id 14699129)1, 2 Bharadwaj R.... Yu H. (J. Biol. Chem. 2004)
    4. The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment. (PubMed id 14738735)1, 2 McCleland M.L.... Stukenberg P.T. (Curr. Biol. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)1 Stehling O.... Lill R. (Science 2012)
    9. Aurora B controls kinetochore-microtubule attachments by inhibiting Ska complex-KMN network interaction. (PubMed id 22371557)1 Chan Y.W....Santamaria A. (J. Cell Biol. 2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57405 HGNC: 24031 AceView: Spc25 Ensembl:ENSG00000152253 euGenes: HUgn57405
    ECgene: SPC25 H-InvDB: SPC25

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SPC25 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SPC25 gene:
    Search GeneIP for patents involving SPC25

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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