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Aliases for SPC25 Gene

Aliases for SPC25 Gene

  • SPC25, NDC80 Kinetochore Complex Component 2 3
  • SPBC25 3 4
  • HSpc25 3 4
  • SPC25, NDC80 Kinetochore Complex Component, Homolog (S. Cerevisiae) 2
  • Spindle Pole Body Component 25 Homolog (S. Cerevisiae) 2
  • SPC25, NDC80 Kinetochore Complex Component, Homolog 3
  • Spindle Pole Body Component 25 Homolog 3
  • Kinetochore Protein Spc25 3
  • 2600017H08Rik 3
  • AD024 3

External Ids for SPC25 Gene

Previous HGNC Symbols for SPC25 Gene

  • SPBC25

Previous GeneCards Identifiers for SPC25 Gene

  • GC02M169436
  • GC02M169690
  • GC02M161623

Summaries for SPC25 Gene

Entrez Gene Summary for SPC25 Gene

  • This gene encodes a protein that may be involved in kinetochore-microtubule interaction and spindle checkpoint activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for SPC25 Gene

SPC25 (SPC25, NDC80 Kinetochore Complex Component) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for SPC25 Gene

  • Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPC25 Gene

Genomics for SPC25 Gene

Regulatory Elements for SPC25 Gene

Genomic Location for SPC25 Gene

Start:
168,834,132 bp from pter
End:
168,913,371 bp from pter
Size:
79,240 bases
Orientation:
Minus strand

Genomic View for SPC25 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPC25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPC25 Gene

Proteins for SPC25 Gene

  • Protein details for SPC25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBM1-SPC25_HUMAN
    Recommended name:
    Kinetochore protein Spc25
    Protein Accession:
    Q9HBM1
    Secondary Accessions:
    • A8K4X8
    • D3DPC0

    Protein attributes for SPC25 Gene

    Size:
    224 amino acids
    Molecular mass:
    26153 Da
    Quaternary structure:
    • Component of the NDC80 complex, which consists of NDC80/HEC1, CDCA1, SPBC24 and SPBC25. The NDC80 complex is formed by two subcomplexes composed of NDC80/HEC1-CDCA1 and SPBC24-SPBC25. Each subcomplex is formed by parallel interactions through the coiled-coil domains of individual subunits. Formation of a tetrameric complex is mediated by interactions between the C-terminal regions of both subunits of the NDC80/HEC1-CDCA1 subcomplex and the N-terminal regions of both subunits of the SPBC24-SPBC25 complex. The tetrameric NDC80 complex has an elongated rod-like structure with globular domains at either end.

    Three dimensional structures from OCA and Proteopedia for SPC25 Gene

neXtProt entry for SPC25 Gene

Proteomics data for SPC25 Gene at MOPED

Post-translational modifications for SPC25 Gene

  • Ubiquitination at Lys19
  • Modification sites at PhosphoSitePlus

Other Protein References for SPC25 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SPC25 Gene

Domains for SPC25 Gene

Protein Domains for SPC25 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPC25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HBM1

UniProtKB/Swiss-Prot:

SPC25_HUMAN :
  • Q9HBM1
Family:
  • Belongs to the SPC25 family.
genes like me logo Genes that share domains with SPC25: view

No data available for Gene Families for SPC25 Gene

Function for SPC25 Gene

Molecular function for SPC25 Gene

UniProtKB/Swiss-Prot Function: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore.

Gene Ontology (GO) - Molecular Function for SPC25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14699129
genes like me logo Genes that share ontologies with SPC25: view

Phenotypes for SPC25 Gene

genes like me logo Genes that share phenotypes with SPC25: view

Animal Model Products

CRISPR Products

miRNA for SPC25 Gene

miRTarBase miRNAs that target SPC25

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPC25

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SPC25 Gene

Localization for SPC25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPC25 Gene

Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPC25 Gene COMPARTMENTS Subcellular localization image for SPC25 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SPC25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000777 condensed chromosome kinetochore IDA 14699129
GO:0005634 nucleus IEA --
GO:0005829 cytosol TAS --
GO:0031262 Ndc80 complex IDA 14699129
genes like me logo Genes that share ontologies with SPC25: view

Pathways for SPC25 Gene

genes like me logo Genes that share pathways with SPC25: view

Pathways by source for SPC25 Gene

Gene Ontology (GO) - Biological Process for SPC25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007052 mitotic spindle organization IMP 14699129
GO:0007059 chromosome segregation IMP 14699129
GO:0007067 mitotic nuclear division IEA --
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with SPC25: view

Transcripts for SPC25 Gene

Unigene Clusters for SPC25 Gene

SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPC25

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPC25 Gene

No ASD Table

Relevant External Links for SPC25 Gene

GeneLoc Exon Structure for
SPC25
ECgene alternative splicing isoforms for
SPC25

Expression for SPC25 Gene

mRNA expression in normal human tissues for SPC25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPC25 Gene

SOURCE GeneReport for Unigene cluster for SPC25 Gene Hs.421956

genes like me logo Genes that share expressions with SPC25: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SPC25 Gene

Orthologs for SPC25 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPC25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPC25 35
  • 99.55 (n)
  • 99.1 (a)
SPC25 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPC25 35
  • 91.67 (n)
  • 90.62 (a)
SPC25 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPC25 35
  • 88.39 (n)
  • 86.16 (a)
SPC25 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spc25 35
  • 80.95 (n)
  • 74.55 (a)
Spc25 16
Spc25 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPC25 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPC25 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spc25 35
  • 81.7 (n)
  • 79.02 (a)
chicken
(Gallus gallus)
Aves SPC25 35
  • 62.16 (n)
  • 47.75 (a)
SPC25 36
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPC25 36
  • 29 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spc25 35
  • 57.1 (n)
  • 45.45 (a)
zebrafish
(Danio rerio)
Actinopterygii spc25 35
  • 52.44 (n)
  • 38.01 (a)
spc25 36
  • 30 (a)
OneToOne
Species with no ortholog for SPC25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPC25 Gene

ENSEMBL:
Gene Tree for SPC25 (if available)
TreeFam:
Gene Tree for SPC25 (if available)

Paralogs for SPC25 Gene

No data available for Paralogs for SPC25 Gene

Variants for SPC25 Gene

Sequence variations from dbSNP and Humsavar for SPC25 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs475467 -- 168,883,388(+) TATTA(C/T)GTCAA intron-variant
rs477309 -- 168,883,608(+) CTACC(C/T)CATTC intron-variant
rs480731 -- 168,887,764(+) AATAG(C/T)AGTAA intron-variant
rs493816 -- 168,881,727(+) CTATA(C/T)TGTCA intron-variant
rs494859 -- 168,881,876(+) ATGAT(A/C)TGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPC25 Gene

Variant ID Type Subtype PubMed ID
nsv875381 CNV Loss 21882294
nsv3023 CNV Insertion 18451855
esv999271 CNV Insertion 20482838
nsv227 CNV Insertion 15895083

Relevant External Links for SPC25 Gene

HapMap Linkage Disequilibrium report
SPC25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPC25 Gene

Disorders for SPC25 Gene

No disorders were found for SPC25 Gene.

No data available for UniProtKB/Swiss-Prot for SPC25 Gene

Publications for SPC25 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  3. Architecture of the human Ndc80-Hec1 complex, a critical constituent of the outer kinetochore. (PMID: 15961401) Ciferri C. … Musacchio A. (J. Biol. Chem. 2005) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  5. Identification of two novel components of the human NDC80 kinetochore complex. (PMID: 14699129) Bharadwaj R. … Yu H. (J. Biol. Chem. 2004) 3 4

Products for SPC25 Gene

Sources for SPC25 Gene

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