Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPC25 Gene

protein-coding   GIFtS: 46
GCID: GC02M169690

SPC25, NDC80 kinetochore complex component, homolog (S....

(Previous name: spindle pole body component 25 homolog (S. cerevisiae)...)
(Previous symbol: SPBC25)
  Search for SPC25
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SPC25    

Aliases
for SPC25 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
SPC25, NDC80 Kinetochore Complex Component, Homolog (S. Cerevisiae)1 2     Spindle Pole Body Component 25 Homolog (S. Cerevisiae)1
SPBC251 2 3     2600017H08Rik2
HSpc251     Kinetochore Protein Spc252
AD0241     Spindle Pole Body Component 25 Homolog2
MGC222281     

External Ids:    HGNC: 240311   Entrez Gene: 574052   Ensembl: ENSG000001522537   OMIM: 6093955   UniProtKB: Q9HBM13   

Export aliases for SPC25 gene to outside databases

Previous GC identifers: GC02M169436 GC02M161623


Summaries
for SPC25 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SPC25:
This gene encodes a protein that may be involved in kinetochore-microtubule interaction and spindle checkpoint
activity. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SPC25_HUMAN, Q9HBM1
Function: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome
segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable
microtubule binding sites in the outer plate of the kinetochore




Genomic Views
for SPC25 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPC25 gene promoter:
         NF-YA   NF-YC   CBF-C   NF-YB   CBF-B   CBF-A   CP1C   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SPC25 promoter sequence
   Search SABiosciences Chromatin IP Primers for SPC25

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPC25


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

SPC25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPC25 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M169690:  view genomic region     (about GC identifiers)

Start:
 169,690,642 bp from pter      End:
 169,769,881 bp from pter
Size:
 79,240 bases      Orientation:
 minus strand

1 alternative location:
Chr2-,PATCHES 169,735,898-169,755,439     

Proteins
for SPC25 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SPC25_HUMAN, Q9HBM1 (See protein sequence)
Recommended Name: Kinetochore protein Spc25  
Size: 224 amino acids; 26153 Da
Subunit: Component of the NDC80 complex, which consists of NDC80/HEC1, CDCA1, SPBC24 and SPBC25. The NDC80 complex is
formed by two subcomplexes composed of NDC80/HEC1-CDCA1 and SPBC24-SPBC25. Each subcomplex is formed by parallel
interactions through the coiled-coil domains of individual subunits. Formation of a tetrameric complex is mediated by
interactions between the C-terminal regions of both subunits of the NDC80/HEC1-CDCA1 subcomplex and the N-terminal
regions of both subunits of the SPBC24-SPBC25 complex. The tetrameric NDC80 complex has an elongated rod-like
structure with globular domains at either end
Subcellular location: Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase
to anaphase. Localizes specifically to the outer plate of the kinetochore
2 PDB 3D structures from and Proteopedia for SPC25:
2VE7 (3D)        3IZ0 (3D)    
Secondary accessions: A8K4X8 D3DPC0

Explore the universe of human proteins at neXtProt for SPC25: NX_Q9HBM1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9HBM1

    • SPC25 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_065726.1  
    ENSEMBL proteins: 
     ENSP00000282074   ENSP00000393322  
    Reactome Protein details: Q9HBM1
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: SPC25
    OriGene Custom Protein Services for SPC25 
    GenScript Custom Purified and Recombinant Proteins Services for SPC25
    Novus Biologicals SPC25 Protein
    Novus Biologicals SPC25 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SPC25

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000777condensed chromosome kinetochore IDA14699129
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--
    GO:0031262Ndc80 complex IDA14699129


    SPC25 for ontologies           About GeneDecksing



    SPC25 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SPC25 
    GenScript Custom Superior Antibodies Services for SPC25
    Novus Biologicals SPC25 Antibodies
    Search for Antibodies for SPC25 at Abcam  
    Uscn Antibodies for SPC25
    Search ThermoFisher Antibodies for SPC25

    Assay Products for SPC25: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SPC25
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SPC25

    Protein Domains /
    Families
    for SPC25 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SPC25 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR013255 Spc25

    Graphical View of Domain Structure for InterPro Entry Q9HBM1

    ProtoNet protein and cluster: Q9HBM1

    UniProtKB/Swiss-Prot: SPC25_HUMAN, Q9HBM1
    Similarity: Belongs to the SPC25 family


    Function
    for SPC25 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SPC25_HUMAN, Q9HBM1
    Function: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome
    segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable
    microtubule binding sites in the outer plate of the kinetochore

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPC25
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SPC25
    SwitchGear 3'UTR luciferase reporter plasmid: SPC25 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPC25 (see all 7)
    OriGene shRNA RFP: SPC25
    OriGene siRNA: SPC25
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPC25

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SPC25

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPC25 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPC25
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SPC25 (NM_020675)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPC25
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPC25 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SPC25
    Search LifeMap BioReagents cell lines for SPC25

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPC25

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--


    SPC25 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for SPC25:
     Cell cycle / mitosis defect  Cell division defect  Increased G2M DNA content  Increased number of mitotic ce 


    Pathways & Interactions
    for SPC25 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1M Phase
    		M Phase1.00
    		Mitotic Anaphase0.85
    		Mitotic M-M/G1 phases0.88
    		Separation of Sister Chromatids0.80
    		Mitotic Metaphase and Anaphase0.85
    2Resolution of Sister Chromatid Cohesion
    		Resolution of Sister Chromatid Cohesion1.00
    		Mitotic Prometaphase0.93
    		Kinetochore assembly0.96
    3Cell Cycle
    		Cell Cycle1.00
    		Cell Cycle, Mitotic0.84

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/10        Reactome Pathways for SPC25 (see all 10)
        Mitotic Metaphase and Anaphase
    Mitotic Prometaphase
    Resolution of Sister Chromatid Cohesion
    Mitotic Anaphase
    Cell Cycle



    SPC25 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SPC25

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/73 Interacting proteins for SPC25 (Q9HBM11, 3 ENSP000002820744) via UniProtKB, MINT, STRING, and/or I2D (see all 73)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NDC80O147771, 3, ENSP000002615974EBI-999909,EBI-715849 I2D: score=5 STRING: ENSP00000261597
    SPC24Q8NBT21, 3, ENSP000003971314EBI-999909,EBI-999900 I2D: score=1 STRING: ENSP00000397131
    MIS12Q9H0813, ENSP000003705574I2D: score=2 STRING: ENSP00000370557
    ZWINTO952293, ENSP000003630554I2D: score=2 STRING: ENSP00000363055
    BUB1O436833, ENSP000003025304I2D: score=2 STRING: ENSP00000302530
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000087M phase of mitotic cell cycle TAS--
    GO:0000236mitotic prometaphase TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0007052mitotic spindle organization IMP14699129
    GO:0007059chromosome segregation IMP14699129


    SPC25 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SPC25 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPC25
    Search CenterWatch for drugs/clinical trials and news about SPC25 

    Transcripts
    for SPC25 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SPC25 gene: 
    NM_020675.3  

    Unigene Cluster for SPC25:

    SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
    Hs.421956  [show with all ESTs]
    Unigene Representative Sequence: BC022255
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000479309 ENST00000282074(uc002uel.3) ENST00000451987 ENST00000472216


    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPC25
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SPC25
    SwitchGear 3'UTR luciferase reporter plasmid: SPC25 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPC25 (see all 7)
    OriGene shRNA RFP: SPC25
    OriGene siRNA: SPC25
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPC25
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPC25 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPC25
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SPC25 (NM_020675)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPC25
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPC25 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPC25
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPC25
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPC25
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPC25

    Additional cDNA sequence: 

    AF225416.1 AK291093.1 AY456388.1 BC022255.1 CR457197.1 

    3 DOTS entries:

    DT.113739  DT.75117421  DT.95160225 

    24/84 AceView cDNA sequences (see all 84):

    CK825801 AA701565 BQ441900 AA761074 AA286680 CR457197 BX105588 AY456388 
    BG236186 AA707088 AA287517 CR590224 NM_020675 BI093154 CR610550 AI990567 
    BC022255 BQ775112 AI656904 BU571173 AA628502 AW086472 AI500149 AA533110 

    GeneLoc Exon Structure


    Expression
    for SPC25 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPC25 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SPC25 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyS-shaped BodyKidney Endothelial CellsEndothelium
    Neural TubeDiencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SPC25 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPC25

    SOURCE GeneReport for Unigene cluster: Hs.421956
        SABiosciences Custom PCR Arrays for SPC25
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPC25
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPC25
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPC25
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPC25
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPC25

    Orthologs
    for SPC25 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for SPC25 gene from 4/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Spc251 , 5 SPC25, NDC80 kinetochore complex component, homolog more1, 5 81.1(n)1
    74.55(a)1    		   2 (39.64 cM)5
    664421  NM_001199124.11  NP_001186053.11 
     691938955 
    chicken
    (Gallus gallus)    		 Aves SPC251 SPC25, NDC80 kinetochore complex component, homolog more 62.84(n)
    48.62(a)    		   424172  XM_422018.2  XP_422018.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SPC256
    		 --
    		 38(a)
    		 1 ↔ 1
    		 1(245303667-245306723)
    zebrafish
    (Danio rerio)    		 Actinopterygii spc251 SPC25, NDC80 kinetochore complex component, homolog more 52.44(n)
    38.01(a)    		   100144563  NM_001123057.1  NP_001116529.1 


    ENSEMBL Gene Tree for SPC25 (if available)
    TreeFam Gene Tree for SPC25 (if available) 

    Paralogs
    for SPC25 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for SPC25 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/399 NCBI SNPs in SPC25 are shown (see all 399)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs58362101,2
    		C--161624082(+) ACTAG-/AAAAAAAA 1 -- int11Minor allele frequency- AAA:0.00NA 2
    rs105452871,2
    		C--161624082(+) ACTAG-/AAAAAAAA 1 -- int10--------
    rs1865432111,2
    		--169727075(+) CACTTC/GTCAAA 1 -- ds50010--------
    rs1921511881,2
    		--169727395(+) TCATGC/TTGCTA 1 -- ds50010--------
    rs1431489121,2
    		--169727582(+) TGAAGA/CTGGAA 1 -- ut310--------
    rs1113722831,2
    		C,--169727610(+) ACTATT/CGAAAG 1 -- ut312Minor allele frequency- C:0.33CSA 3
    rs67349231,2
    		C,F,A,H,--169727730(+) GGGAGC/GGGGGA 1 -- ut31 trp35Minor allele frequency- G:0.44NA CSA 9
    rs621767811,2
    		--169727863(+) GTATAG/ATAATA 1 -- ut311Minor allele frequency- A:0.50NA 2
    rs114205141,2
    		C,--169727877(+) ACAAGA/-AAAAA 1 -- ut31 trp31Minor allele frequency- -:0.00CSA 2
    rs615988341,2
    		C--169727880(+) AAAAGA/-AGATA 1 -- ut311Minor allele frequency- -:0.00NA 2

    HapMap Linkage Disequilibrium report for SPC25 (169690642 - 169769881 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for SPC25
         6 CNVs: 35753 0533 35755 35756 35754 35757

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPC25
    DNA2.0 Custom Variant and Variant Library Synthesis for SPC25

    Disorders / Diseases
    for SPC25 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SPC25 for disorders           About MalaCards

    SPC25 for disorders           About GeneDecksing

    OMIM gene information: 609395    OMIM disorders: --


    Export disorders for SPC25 gene to outside databases

    Publications
    for SPC25 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPC25 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with SPC25)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Architecture of the human Ndc80-Hec1 complex, a critical constituent of the outer kinetochore. (PubMed id 15961401)1, 2 Ciferri C.... Musacchio A. (2005)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    3. Identification of two novel components of the human NDC80 kinetochore complex. (PubMed id 14699129)1, 2 Bharadwaj R.... Yu H. (2004)
    4. The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment. (PubMed id 14738735)1, 2 McCleland M.L.... Stukenberg P.T. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Aurora B controls kinetochore-microtubule attachments by inhibiting Ska complex-KMN network interaction. (PubMed id 22371557)1 Chan Y.W....Santamaria A. (2012)
    9. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    10. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)

    External Searches for SPC25 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SPC25 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57405 HGNC: 24031 AceView: Spc25 Ensembl:ENSG00000152253 euGenes: HUgn57405
    ECgene: SPC25 H-InvDB: SPC25

    Other Databases showing SPC25 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SPC25 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPC25 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SPC25 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SPC25 gene:
    Search GeneIP for patents involving SPC25

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SPC25 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for SPC25  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPC25   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPC25  
     OriGene Protein Over-expression Lysate for SPC25   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for SPC25   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPC25   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPC25  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SPC25   OriGene Custom Protein Services for SPC25  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPC25
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPC25
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPC25
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPC25
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPC25
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPC25
     GenScript Custom Purified and Recombinant Proteins Services for SPC25 GenScript cDNA clones with any tag delivered in your preferred vector for SPC25
     GenScript Custom Assay Services for SPC25 GenScript Custom Superior Antibodies Services for SPC25
     GenScript Custom overexpressing Cell Line Services for SPC25 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SPC25 promoter
     Search Chromatin IP Primers for SPC25
     RT2 qPCR Primer Assay in human, mouse, rat SPC25
     GNC Network for SPC25
     SABiosciences Custom PCR Arrays for SPC25
     Search Tocris compounds for SPC25
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SPC25 antibodies
     SPC25 proteins
     SPC25 lysates
     Search for Antibodies for SPC25 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SPC25
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     SPC25 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SPC25
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPC25
     SwitchGear 3'UTR luciferase reporter plasmids for SPC25
     SwitchGear Promoter luciferase reporter plasmids for SPC25
     Search ThermoFisher Antibodies for SPC25
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPC25
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      SPC25 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4