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SPC24 Gene

protein-coding   GIFtS: 52
GCID: GC19M011257

SPC24, NDC80 Kinetochore Complex Component

(Previous names: spindle pole body component 24 homolog (S. cerevisiae),...)
(Previous symbol: SPBC24)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SPC24, NDC80 Kinetochore Complex Component1 2     Spindle Pole Body Component 24 Homolog (S. Cerevisiae)1
SPBC241 2 3     Kinetochore Protein Spc242
hSpc242 3     SPC24, NDC80 Kinetochore Complex Component, Homolog2
SPC24, NDC80 Kinetochore Complex Component, Homolog (S. Cerevisiae)1     Spindle Pole Body Component 24 Homolog2

External Ids:    HGNC: 269131   Entrez Gene: 1478412   Ensembl: ENSG000001618887   OMIM: 6093945   UniProtKB: Q8NBT23   

Export aliases for SPC24 gene to outside databases

Previous GC identifers: GC19M011119 GC19M010834


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SPC24 Gene:
SPC24 (SPC24, NDC80 kinetochore complex component) is a protein-coding gene.

UniProtKB/Swiss-Prot: SPC24_HUMAN, Q8NBT2
Function: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for
chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization
of stable microtubule binding sites in the outer plate of the kinetochore

Gene Wiki entry for SPC24 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPC24 gene promoter:
         ER-alpha   GR   p300   Pax-6   GR-beta   MIF-1   XBP-1   Arnt   SEF-1 (1)   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPC24 promoter sequence
   Search Chromatin IP Primers for SPC24

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPC24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

SPC24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPC24 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M011257:  view genomic region     (about GC identifiers)

Start:
11,242,196 bp from pter      End:
11,266,484 bp from pter
Size:
24,289 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SPC24_HUMAN, Q8NBT2 (See protein sequence)
Recommended Name: Kinetochore protein Spc24  
Size: 197 amino acids; 22478 Da
Subunit: Component of the NDC80 complex, which consists of NDC80/HEC1, CDCA1, SPBC24 and SPBC25. The NDC80 complex
is formed by two subcomplexes composed of NDC80/HEC1-CDCA1 and SPBC24-SPBC25. Each subcomplex is formed by
parallel interactions through the coiled-coil domains of individual subunits. Formation of a tetrameric complex
is mediated by interactions between the C-terminal regions of both subunits of the NDC80/HEC1-CDCA1 subcomplex
and the N-terminal regions of both subunits of the SPBC24-SPBC25 complex. The tetrameric NDC80 complex has an
elongated rod-like structure with globular domains at either end
2 PDB 3D structures from and Proteopedia for SPC24:
2VE7 (3D)        3IZ0 (3D)    
Secondary accessions: C9JGC4

Explore the universe of human proteins at neXtProt for SPC24: NX_Q8NBT2

Explore proteomics data for SPC24 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys50, Lys60, Lys70, Lys161
  • Modification sites at PhosphoSitePlus

  • See SPC24 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_872319.1  
    ENSEMBL proteins: 
     ENSP00000468818   ENSP00000465075   ENSP00000466688   ENSP00000465335   ENSP00000397131  
     ENSP00000468366   ENSP00000465167  
    Reactome Protein details: Q8NBT2

    SPC24 Human Recombinant Protein Products:

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    Novus Biologicals SPC24 Protein
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    Cloud-Clone Corp. Proteins for SPC24

     
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    antibodies-online proteins for SPC24 (7 products) 

     
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    SPC24 Antibody Products:

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    Cloud-Clone Corp. ELISAs for SPC24
    Cloud-Clone Corp. CLIAs for SPC24
    Search eBioscience for ELISAs for SPC24 
    antibodies-online kits for SPC24 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR013252 Ndc80_Spc24

    Graphical View of Domain Structure for InterPro Entry Q8NBT2

    ProtoNet protein and cluster: Q8NBT2

    UniProtKB/Swiss-Prot: SPC24_HUMAN, Q8NBT2
    Similarity: Belongs to the SPC24 family


    Find genes that share domains with SPC24           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPC24_HUMAN, Q8NBT2
    Function: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for
    chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization
    of stable microtubule binding sites in the outer plate of the kinetochore

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14738735
         
    Find genes that share ontologies with SPC24           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SPC24:
     Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SPC24

    miRNA
    Products:
        
    miRTarBase miRNAs that target SPC24:
    hsa-mir-92b-3p (MIRT040615), hsa-mir-1 (MIRT023587)

    Block miRNA regulation of human, mouse, rat SPC24 using miScript Target Protectors
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPC24

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPC24


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPC24_HUMAN, Q8NBT2: Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late
    prophase to anaphase. Localizes specifically to the outer plate of the kinetochore
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton2
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005829cytosol TAS--
    GO:0031262Ndc80 complex IDA14699129

    Find genes that share ontologies with SPC24           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SPC24 About    
    See pathways by source

    SuperPathContained pathways About
    1Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    3Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92
    4PLK1 signaling events
    PLK1 signaling events


    Find genes that share SuperPaths with SPC24           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SPC24
        PLK1 signaling events

    3 Reactome Pathways for SPC24
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Separation of Sister Chromatids


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPC24
    Interactions:

        GeneGlobe Interaction Network for SPC24

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SPC24 (Q8NBT21, 3 ENSP000003971314) via UniProtKB, MINT, STRING, and/or I2D (see all 71)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SPC25Q9HBM11, 3, ENSP000002820744EBI-999900,EBI-999909 I2D: score=1 STRING: ENSP00000282074
    MIS12Q9H0813, ENSP000003705574I2D: score=2 STRING: ENSP00000370557
    ZWINTO952293, ENSP000003630554I2D: score=2 STRING: ENSP00000363055
    NDC80O147773, ENSP000002615974I2D: score=3 STRING: ENSP00000261597
    BUB1O436833, ENSP000003025304I2D: score=2 STRING: ENSP00000302530
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0007067mitosis IEA--

    Find genes that share ontologies with SPC24           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPC24



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SPC24 gene: 
    NM_182513.2  

    Unigene Cluster for SPC24:

    SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)
    Hs.381225  [show with all ESTs]
    Unigene Representative Sequence: AK075287
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000585567 ENST00000592540 ENST00000591396 ENST00000592967 ENST00000423327(uc002mql.2)
    ENST00000586708 ENST00000585486
    miRNA
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SPC24
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPC24
      QuantiTect SYBR Green Assays in human, mouse, rat SPC24
      QuantiFast Probe-based Assays in human, mouse, rat SPC24

    Additional mRNA sequence: 

    AK075287.1 AK303157.1 AK303266.1 AY456387.1 BC105037.1 BC105039.1 

    4 DOTS entries:

    DT.100024080  DT.40208734  DT.70100755  DT.97833674 

    Selected AceView cDNA sequences (see all 50):

    AW087430 BQ063818 BQ642409 BQ061822 AI564835 BP871131 AY456387 BQ063909 
    BI029235 BQ650106 BI042802 BQ929089 BU953663 AW246001 BG167737 NM_182513 
    BG201978 BQ643295 BU616832 AI498957 BX100406 BP432898 AI652568 BQ216591 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SPC24 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAAGGAAG
    SPC24 Expression
    About this image


    SPC24 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Mesencephalic Ventricular Zone
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
    SPC24 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPC24 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.381225
        Custom PCR Arrays for SPC24
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPC24

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SPC24 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spc241 , 5 SPC24, NDC80 kinetochore complex component, homolog more1, 5 79.53(n)1
    73.6(a)1
      9 (7.88 cM)5
    676291  NM_026282.51  NP_080558.11 
     217554425 
    lizard
    (Anolis carolinensis)
    Reptilia SPC246
    SPC24, NDC80 kinetochore complex component
    39(a)
    1 ↔ 1
    2(28599765-28608279)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia spc241 SPC24, NDC80 kinetochore complex component 56.26(n)
    42.33(a)
      394654  NM_203726.1  NP_989057.1 
    zebrafish
    (Danio rerio)
    Actinopterygii spc241 SPC24, NDC80 kinetochore complex component, homolog more 46.87(n)
    33.85(a)
      554147  NM_001024440.1  NP_001019611.1 


    ENSEMBL Gene Tree for SPC24 (if available)
    TreeFam Gene Tree for SPC24 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SPC24 (see all 285)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1127228871,2
    C--11257356(+) GAATGA/GCGTGA 1 -- ds50011Minor allele frequency- G:0.00CSA 1
    rs1814725781,2
    --11257409(+) ACTGCA/CCTCCA 1 -- ds50010--------
    rs81112261,2
    C,F--11257430(+) cagagC/Tgagac 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1416187581,2
    --11257499(+) TGGAAC/TCCTAG 1 -- ds50010--------
    rs1505193271,2
    C--11257502(+) AATCCC/TAGCAC 1 -- ds50010--------
    rs1864516691,2
    --11257692(+) CAGAGC/GTTGCT 1 -- ds50010--------
    rs104229491,2
    C,F,H--11257780(+) ATCTAT/CGTCCC 1 -- ds500110Minor allele frequency- C:0.13NS EA NA WA 768
    rs1925073551,2
    --11257840(+) AAGACA/GCAGCC 1 -- ut310--------
    rs1838364741,2
    C,F--11257848(+) GCCACG/AAGGCT 1 -- ut311Minor allele frequency- A:0.01EU 283
    rs2002066191,2
    C--11257865(+) TACCAA/CTCGGT 2 E D mis10--------

    HapMap Linkage Disequilibrium report for SPC24 (11242196 - 11266484 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SPC24:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3729n71CNV Loss21882294
    nsv833751CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SPC24
    DNA2.0 Custom Variant and Variant Library Synthesis for SPC24

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609394    OMIM disorders: --


    Find genes that share disorders with SPC24           About GenesLikeMe

    Genetic Association Database (GAD): SPC24

    Export disorders for SPC24 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SPC24 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with SPC24)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores. (PubMed id 15964272)1, 2, 9 Ahonen L.J.... Gorbsky G.J. (Curr. Biol. 2005)
    2. Architecture of the human Ndc80-Hec1 complex, a critical constituent of the outer kinetochore. (PubMed id 15961401)1, 2 Ciferri C.... Musacchio A. (J. Biol. Chem. 2005)
    3. Identification of two novel components of the human NDC80 kinetochore complex. (PubMed id 14699129)1, 2 Bharadwaj R.... Yu H. (J. Biol. Chem. 2004)
    4. The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment. (PubMed id 14738735)1, 2 McCleland M.L.... Stukenberg P.T. (Curr. Biol. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    8. Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci. (PubMed id 23505323)1 Weissglas-Volkov D....Pajukanta P. (J. Med. Genet. 2013)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 147841 HGNC: 26913 AceView: Spc24 Ensembl:ENSG00000161888 euGenes: HUgn147841
    ECgene: SPC24 H-InvDB: SPC24

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SPC24 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SPC24 gene:
    Search GeneIP for patents involving SPC24

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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