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Aliases for SPC24 Gene

Aliases for SPC24 Gene

  • SPC24, NDC80 Kinetochore Complex Component 2 3 5
  • SPBC24 3 4
  • HSpc24 3 4
  • SPC24, NDC80 Kinetochore Complex Component, Homolog (S. Cerevisiae) 2
  • Spindle Pole Body Component 24 Homolog (S. Cerevisiae) 2
  • SPC24, NDC80 Kinetochore Complex Component, Homolog 3
  • Spindle Pole Body Component 24 Homolog 3
  • Kinetochore Protein Spc24 3

External Ids for SPC24 Gene

Previous HGNC Symbols for SPC24 Gene

  • SPBC24

Previous GeneCards Identifiers for SPC24 Gene

  • GC19M011257
  • GC19M010834

Summaries for SPC24 Gene

GeneCards Summary for SPC24 Gene

SPC24 (SPC24, NDC80 Kinetochore Complex Component) is a Protein Coding gene. Among its related pathways are PLK1 signaling events and Mitotic Metaphase and Anaphase.

UniProtKB/Swiss-Prot for SPC24 Gene

  • Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).

Gene Wiki entry for SPC24 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPC24 Gene

Genomics for SPC24 Gene

Regulatory Elements for SPC24 Gene

Enhancers for SPC24 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G011140 2.5 VISTA FANTOM5 Ensembl ENCODE dbSUPER 9.4 +12.3 12311 5.4 PKNOX1 MLX AGO1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 SPC24 DOCK6 YIPF2 TMED1 PRKCSH CARM1 ECSIT MIR6886
GH19G011150 1.7 Ensembl ENCODE dbSUPER 11.2 +2.2 2180 6.3 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC ZNF700 TIMM29 ZNF440 RAVER1 ZNF878 ZNF441 ZNF627 PRKCSH SPC24 ZNF844
GH19G011179 1.3 Ensembl ENCODE dbSUPER 12.9 -24.2 -24205 1.2 WRNIP1 BACH1 BMI1 EBF1 ZBTB40 RELA ZNF664 POLR2A EED ZNF207 SPC24 PLPPR2 GC19P011173 KANK2
GH19G011157 1.5 Ensembl ENCODE dbSUPER 9.8 -1.9 -1917 1.2 ATF1 ARNT ARID4B FEZF1 ZNF48 YY1 TCF12 GATA2 FOS NCOA1 SPC24 GC19P011173
GH19G011255 1.2 Ensembl ENCODE dbSUPER 11.8 -100.3 -100308 1.4 BCOR ZNF263 SMARCA5 TFAP4 KLF1 SAP130 CEBPB ZMYM3 ZKSCAN1 ZNF664 ENSG00000267174 SPC24 DOCK6 GC19P011251
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPC24 on UCSC Golden Path with GeneCards custom track

Promoters for SPC24 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000107139 402 1201 PKNOX1 FOXA2 CREB3L1 MLX ARNT WRNIP1 ZFP64 ARID4B SIN3A DMAP1

Genomic Location for SPC24 Gene

Chromosome:
19
Start:
11,131,520 bp from pter
End:
11,156,002 bp from pter
Size:
24,483 bases
Orientation:
Minus strand

Genomic View for SPC24 Gene

Genes around SPC24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPC24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPC24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPC24 Gene

Proteins for SPC24 Gene

  • Protein details for SPC24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBT2-SPC24_HUMAN
    Recommended name:
    Kinetochore protein Spc24
    Protein Accession:
    Q8NBT2
    Secondary Accessions:
    • B4DZZ7
    • C9JGC4

    Protein attributes for SPC24 Gene

    Size:
    197 amino acids
    Molecular mass:
    22478 Da
    Quaternary structure:
    • Component of the NDC80 complex, which consists of NDC80/HEC1, CDCA1, SPBC24 and SPBC25. The NDC80 complex is formed by two subcomplexes composed of NDC80/HEC1-CDCA1 and SPBC24-SPBC25. Each subcomplex is formed by parallel interactions through the coiled-coil domains of individual subunits. Formation of a tetrameric complex is mediated by interactions between the C-terminal regions of both subunits of the NDC80/HEC1-CDCA1 subcomplex and the N-terminal regions of both subunits of the SPBC24-SPBC25 complex. The tetrameric NDC80 complex has an elongated rod-like structure with globular domains at either end.

    Three dimensional structures from OCA and Proteopedia for SPC24 Gene

    Alternative splice isoforms for SPC24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPC24 Gene

Post-translational modifications for SPC24 Gene

  • Ubiquitination at isoforms=250, isoforms=260, Lys70, and isoforms=2161
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SPC24 Gene

Domains & Families for SPC24 Gene

Protein Domains for SPC24 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPC24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NBT2

UniProtKB/Swiss-Prot:

SPC24_HUMAN :
  • Belongs to the SPC24 family.
Family:
  • Belongs to the SPC24 family.
genes like me logo Genes that share domains with SPC24: view

No data available for Gene Families for SPC24 Gene

Function for SPC24 Gene

Molecular function for SPC24 Gene

UniProtKB/Swiss-Prot Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).

Gene Ontology (GO) - Molecular Function for SPC24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14738735
genes like me logo Genes that share ontologies with SPC24: view
genes like me logo Genes that share phenotypes with SPC24: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SPC24

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPC24 Gene

Localization for SPC24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPC24 Gene

Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore. {ECO:0000269 PubMed:14738735}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPC24 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SPC24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IEA --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IDA --
GO:0005694 chromosome IEA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with SPC24: view

Pathways & Interactions for SPC24 Gene

genes like me logo Genes that share pathways with SPC24: view

Pathways by source for SPC24 Gene

1 BioSystems pathway for SPC24 Gene

Gene Ontology (GO) - Biological Process for SPC24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007062 sister chromatid cohesion TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with SPC24: view

No data available for SIGNOR curated interactions for SPC24 Gene

Drugs & Compounds for SPC24 Gene

No Compound Related Data Available

Transcripts for SPC24 Gene

Unigene Clusters for SPC24 Gene

SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SPC24

Alternative Splicing Database (ASD) splice patterns (SP) for SPC24 Gene

No ASD Table

Relevant External Links for SPC24 Gene

GeneLoc Exon Structure for
SPC24
ECgene alternative splicing isoforms for
SPC24

Expression for SPC24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPC24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SPC24 Gene

This gene is overexpressed in Bone (26.5), Lung (14.2), Pancreas (9.9), and Fetal ovary (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SPC24 Gene



Protein tissue co-expression partners for SPC24 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPC24 Gene:

SPC24

SOURCE GeneReport for Unigene cluster for SPC24 Gene:

Hs.381225
genes like me logo Genes that share expression patterns with SPC24: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPC24 Gene

Orthologs for SPC24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPC24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPC24 34 35
  • 99.15 (n)
cow
(Bos Taurus)
Mammalia SPC24 34 35
  • 87.65 (n)
dog
(Canis familiaris)
Mammalia SPC24 34 35
  • 87.14 (n)
rat
(Rattus norvegicus)
Mammalia Spc24 34
  • 80.54 (n)
mouse
(Mus musculus)
Mammalia Spc24 34 16 35
  • 79.53 (n)
oppossum
(Monodelphis domestica)
Mammalia SPC24 35
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPC24 35
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPC24 35
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spc24 34
  • 56.26 (n)
zebrafish
(Danio rerio)
Actinopterygii spc24 34 35
  • 46.87 (n)
Species where no ortholog for SPC24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPC24 Gene

ENSEMBL:
Gene Tree for SPC24 (if available)
TreeFam:
Gene Tree for SPC24 (if available)

Paralogs for SPC24 Gene

No data available for Paralogs for SPC24 Gene

Variants for SPC24 Gene

Sequence variations from dbSNP and Humsavar for SPC24 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000223596 -- 11,150,355(+) GTGGT(A/G)CATGC intron-variant
rs1000420984 -- 11,156,274(+) CTGTG(C/T)TACCC upstream-variant-2KB
rs1000595410 -- 11,150,589(+) CAGGA(A/G)TTTGA intron-variant
rs1000754176 -- 11,155,051(+) TGCGG(C/T)GGCAA intron-variant
rs1000962783 -- 11,148,827(+) TAGCC(A/G)GGATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPC24 Gene

Variant ID Type Subtype PubMed ID
dgv3427n100 CNV gain 25217958
nsv1065030 CNV gain 25217958
nsv833751 CNV loss 17160897

Variation tolerance for SPC24 Gene

Gene Damage Index Score: 3.53; 55.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPC24 Gene

Human Gene Mutation Database (HGMD)
SPC24
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPC24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPC24 Gene

Disorders for SPC24 Gene

Relevant External Links for SPC24

Genetic Association Database (GAD)
SPC24
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPC24

No disorders were found for SPC24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPC24 Gene

Publications for SPC24 Gene

  1. Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores. (PMID: 15964272) Ahonen L.J. … Gorbsky G.J. (Curr. Biol. 2005) 3 4 22 64
  2. Architecture of the human Ndc80-Hec1 complex, a critical constituent of the outer kinetochore. (PMID: 15961401) Ciferri C. … Musacchio A. (J. Biol. Chem. 2005) 3 4 64
  3. Identification of two novel components of the human NDC80 kinetochore complex. (PMID: 14699129) Bharadwaj R. … Yu H. (J. Biol. Chem. 2004) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment. (PMID: 14738735) McCleland M.L. … Stukenberg P.T. (Curr. Biol. 2004) 3 4 64

Products for SPC24 Gene

  • Addgene plasmids for SPC24

Sources for SPC24 Gene

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