Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SPC24 Gene

Aliases for SPC24 Gene

  • SPC24, NDC80 Kinetochore Complex Component 2 3
  • SPBC24 3 4
  • HSpc24 3 4
  • SPC24, NDC80 Kinetochore Complex Component, Homolog (S. Cerevisiae) 2
  • Spindle Pole Body Component 24 Homolog (S. Cerevisiae) 2
  • SPC24, NDC80 Kinetochore Complex Component, Homolog 3
  • Spindle Pole Body Component 24 Homolog 3
  • Kinetochore Protein Spc24 3

External Ids for SPC24 Gene

Previous HGNC Symbols for SPC24 Gene

  • SPBC24

Previous GeneCards Identifiers for SPC24 Gene

  • GC19M011257
  • GC19M010834

Summaries for SPC24 Gene

GeneCards Summary for SPC24 Gene

SPC24 (SPC24, NDC80 Kinetochore Complex Component) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for SPC24 Gene

  • Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore.

Gene Wiki entry for SPC24 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPC24 Gene

Genomics for SPC24 Gene

Regulatory Elements for SPC24 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SPC24 Gene

Start:
11,131,520 bp from pter
End:
11,155,887 bp from pter
Size:
24,368 bases
Orientation:
Minus strand

Genomic View for SPC24 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPC24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPC24 Gene

Proteins for SPC24 Gene

  • Protein details for SPC24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBT2-SPC24_HUMAN
    Recommended name:
    Kinetochore protein Spc24
    Protein Accession:
    Q8NBT2
    Secondary Accessions:
    • B4DZZ7
    • C9JGC4

    Protein attributes for SPC24 Gene

    Size:
    197 amino acids
    Molecular mass:
    22478 Da
    Quaternary structure:
    • Component of the NDC80 complex, which consists of NDC80/HEC1, CDCA1, SPBC24 and SPBC25. The NDC80 complex is formed by two subcomplexes composed of NDC80/HEC1-CDCA1 and SPBC24-SPBC25. Each subcomplex is formed by parallel interactions through the coiled-coil domains of individual subunits. Formation of a tetrameric complex is mediated by interactions between the C-terminal regions of both subunits of the NDC80/HEC1-CDCA1 subcomplex and the N-terminal regions of both subunits of the SPBC24-SPBC25 complex. The tetrameric NDC80 complex has an elongated rod-like structure with globular domains at either end.

    Three dimensional structures from OCA and Proteopedia for SPC24 Gene

    Alternative splice isoforms for SPC24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPC24 Gene

Proteomics data for SPC24 Gene at MOPED

Post-translational modifications for SPC24 Gene

  • Ubiquitination at Lys50, Lys60, Lys70, and Lys161
  • Modification sites at PhosphoSitePlus

Other Protein References for SPC24 Gene

Antibody Products

No data available for DME Specific Peptides for SPC24 Gene

Domains for SPC24 Gene

Protein Domains for SPC24 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPC24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NBT2

UniProtKB/Swiss-Prot:

SPC24_HUMAN :
  • Q8NBT2
Family:
  • Belongs to the SPC24 family.
genes like me logo Genes that share domains with SPC24: view

No data available for Gene Families for SPC24 Gene

Function for SPC24 Gene

Molecular function for SPC24 Gene

UniProtKB/Swiss-Prot Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore.

Gene Ontology (GO) - Molecular Function for SPC24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14738735
genes like me logo Genes that share ontologies with SPC24: view

Phenotypes for SPC24 Gene

GenomeRNAi human phenotypes for SPC24:
genes like me logo Genes that share phenotypes with SPC24: view

Animal Model Products

miRNA for SPC24 Gene

miRTarBase miRNAs that target SPC24

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPC24

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SPC24 Gene

Localization for SPC24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPC24 Gene

Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPC24 Gene COMPARTMENTS Subcellular localization image for SPC24 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SPC24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005829 cytosol TAS --
GO:0031262 Ndc80 complex IDA 14699129
genes like me logo Genes that share ontologies with SPC24: view

Pathways for SPC24 Gene

genes like me logo Genes that share pathways with SPC24: view

Pathways by source for SPC24 Gene

Gene Ontology (GO) - Biological Process for SPC24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with SPC24: view

Transcripts for SPC24 Gene

Unigene Clusters for SPC24 Gene

SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPC24

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPC24 Gene

No ASD Table

Relevant External Links for SPC24 Gene

GeneLoc Exon Structure for
SPC24
ECgene alternative splicing isoforms for
SPC24

Expression for SPC24 Gene

mRNA expression in normal human tissues for SPC24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for SPC24 Gene

This gene is overexpressed in Bone (26.5), Lung (14.2), Pancreas (9.9), and Fetal ovary (7.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPC24 Gene

SOURCE GeneReport for Unigene cluster for SPC24 Gene Hs.381225

genes like me logo Genes that share expressions with SPC24: view

Expression partners for SPC24 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SPC24 Gene

Orthologs for SPC24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPC24 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SPC24 35
  • 87.65 (n)
  • 89.34 (a)
SPC24 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPC24 35
  • 87.14 (n)
  • 86.8 (a)
SPC24 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spc24 35
  • 79.53 (n)
  • 73.6 (a)
Spc24 16
Spc24 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SPC24 35
  • 99.15 (n)
  • 99.49 (a)
SPC24 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spc24 35
  • 80.54 (n)
  • 79.19 (a)
oppossum
(Monodelphis domestica)
Mammalia SPC24 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPC24 36
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPC24 36
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spc24 35
  • 56.26 (n)
  • 42.33 (a)
zebrafish
(Danio rerio)
Actinopterygii spc24 35
  • 46.87 (n)
  • 33.85 (a)
spc24 36
  • 32 (a)
OneToOne
Species with no ortholog for SPC24:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPC24 Gene

ENSEMBL:
Gene Tree for SPC24 (if available)
TreeFam:
Gene Tree for SPC24 (if available)

Paralogs for SPC24 Gene

No data available for Paralogs for SPC24 Gene

Variants for SPC24 Gene

Sequence variations from dbSNP and Humsavar for SPC24 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs875455 -- 11,156,653(-) gcctt(C/T)caaag upstream-variant-2KB
rs892114 -- 11,155,908(-) TAAGA(C/T)CCTGT upstream-variant-2KB
rs892115 -- 11,152,974(-) CCAGT(A/C)CACGG intron-variant
rs934424 -- 11,156,937(-) taatc(C/T)cagct upstream-variant-2KB
rs934425 -- 11,156,827(-) aaaaa(A/G)agaga upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SPC24 Gene

Variant ID Type Subtype PubMed ID
nsv833751 CNV Loss 17160897
dgv3729n71 CNV Loss 21882294

Relevant External Links for SPC24 Gene

HapMap Linkage Disequilibrium report
SPC24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPC24 Gene

Disorders for SPC24 Gene

Relevant External Links for SPC24

Genetic Association Database (GAD)
SPC24

No disorders were found for SPC24 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SPC24 Gene

Publications for SPC24 Gene

  1. Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores. (PMID: 15964272) Ahonen L.J. … Gorbsky G.J. (Curr. Biol. 2005) 3 4 23
  2. Architecture of the human Ndc80-Hec1 complex, a critical constituent of the outer kinetochore. (PMID: 15961401) Ciferri C. … Musacchio A. (J. Biol. Chem. 2005) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment. (PMID: 14738735) McCleland M.L. … Stukenberg P.T. (Curr. Biol. 2004) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for SPC24 Gene

Sources for SPC24 Gene

Back to Top

Content