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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPATS2L Gene

protein-coding   GIFtS: 49
GCID: GC02P201170

Spermatogenesis Associated, Serine-Rich 2-Like

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Spermatogenesis Associated, Serine-Rich 2-Like1 2     SGNP2 3
DNA Polymerase Transactivated Protein 61 2     DNA Polymerase-Transactivated Protein 62 3
Stress Granule And Nucleolar Protein2 3     SPATS2-Like Protein2
DNAPTP62 3     

External Ids:    HGNC: 245741   Entrez Gene: 260102   Ensembl: ENSG000001961417   OMIM: 6138175   UniProtKB: Q9NUQ63   

Export aliases for SPATS2L gene to outside databases

Previous GC identifers: GC02P200881 GC02P193023


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SPATS2L Gene: 
SPATS2L (spermatogenesis associated, serine-rich 2-like) is a protein-coding gene. Diseases associated with SPATS2L include asthma. An important paralog of this gene is SPATS2.

Gene Wiki entry for SPATS2L Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SPATS2L
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SPATS2L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPATS2L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.1   Ensembl cytogenetic band:  2q33.1   HGNC cytogenetic band: 2q33.1

SPATS2L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPATS2L gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P201170:  view genomic region     (about GC identifiers)

Start:
201,170,604 bp from pter      End:
201,346,986 bp from pter
Size:
176,383 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SPS2L_HUMAN, Q9NUQ6 (See protein sequence)
Recommended Name: SPATS2-like protein  
Size: 558 amino acids; 61729 Da
Subcellular location: Cytoplasm. Nucleus, nucleolus. Note=During oxidative stress as well as UV irradiation,
energy deprivation or heat shock, relocalizes to cytoplasmic stress granules. In the nucleus, found in structures
lacking NPM1
Sequence caution: Sequence=AAG22487.1; Type=Frameshift; Positions=92;
Secondary accessions: A8K381 B7WNZ7 Q53T22 Q8WV53 Q8WYG1 Q9NTW4
Alternative splicing: 2 isoforms:  Q9NUQ6-1   Q9NUQ6-2   

Explore the universe of human proteins at neXtProt for SPATS2L: NX_Q9NUQ6

Explore proteomics data for SPATS2L at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NUQ6

  • SPATS2L Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SPATS2L Protein Expression
    REFSEQ proteins (7 alternative transcripts): 
    NP_001093892.1  NP_001093893.1  NP_001093894.1  NP_001269664.1  NP_001269672.1  NP_001269673.1  NP_056350.2  

    ENSEMBL proteins: 
     ENSP00000406728   ENSP00000386336   ENSP00000351503   ENSP00000386931   ENSP00000386391  
     ENSP00000411294   ENSP00000405506   ENSP00000391467   ENSP00000353989   ENSP00000396109  
     ENSP00000398198   ENSP00000389908   ENSP00000390506   ENSP00000386730   ENSP00000386600  
     ENSP00000386310   ENSP00000402559   ENSP00000413142   ENSP00000413648   ENSP00000405751  
     ENSP00000387333  

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    Cloud-Clone Corp. Proteins for SPATS2L 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm IEA--
    GO:0043234protein complex ----

    SPATS2L for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR009816 DUF1387
     IPR009060 UBA-like

    Graphical View of Domain Structure for InterPro Entry Q9NUQ6

    ProtoNet protein and cluster: Q9NUQ6

    UniProtKB/Swiss-Prot: SPS2L_HUMAN, Q9NUQ6
    Similarity: Belongs to the SPATS2 family


    SPATS2L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    SPATS2L for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SPATS2L:
     Decreased p24 protein expressi 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SPATS2L 
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    miRNA
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    miRTarBase miRNAs that target SPATS2L:
    hsa-mir-21 (MIRT004812)

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    8/99 QIAGEN miScript miRNA Assays for microRNAs that regulate SPATS2L (see all 99):
    hsa-miR-579 hsa-miR-607 hsa-miR-134 hsa-miR-632 hsa-miR-4325 hsa-miR-3613-3p hsa-miR-489 hsa-miR-3116
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPATS2L

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SPATS2L (Q9NUQ63 ENSP000003515034) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPATS2L (SPS2L)

    Search CenterWatch for drugs/clinical trials and news about SPATS2L / SPS2L

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SPATS2L gene (7 alternative transcripts): 
    NM_001100422.1  NM_001100423.1  NM_001100424.1  NM_001282735.1  NM_001282743.1  NM_001282744.1  NM_015535.2  

    Unigene Cluster for SPATS2L:

    Spermatogenesis associated, serine-rich 2-like
    Hs.120323  [show with all ESTs]
    Unigene Representative Sequence: NM_001100422
    18/27 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):
    ENST00000439084 ENST00000409718(uc002uvn.4 uc010fst.3 uc002uvo.4)
    ENST00000358677(uc010zhc.2) ENST00000409988(uc002uvp.4 uc002uvq.4)
    ENST00000409385 ENST00000439395 ENST00000444012 ENST00000451764 ENST00000360760
    ENST00000423749 ENST00000428692 ENST00000471601 ENST00000457757 ENST00000453663
    ENST00000409140(uc002uvr.4) ENST00000459656 ENST00000471533 ENST00000409397

    miRNA
    Products:
         
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    8/99 QIAGEN miScript miRNA Assays for microRNAs that regulate SPATS2L (see all 99):
    hsa-miR-579 hsa-miR-607 hsa-miR-134 hsa-miR-632 hsa-miR-4325 hsa-miR-3613-3p hsa-miR-489 hsa-miR-3116
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    Inhib. RNA
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    Additional mRNA sequence: 

    AF193059.1 AK002064.1 AK021816.1 AK024200.1 AK090703.1 AK090867.1 AK092917.1 AK290496.1 
    AK299223.1 AK300075.1 AK314561.1 AL110124.1 AY450394.1 BC010848.1 BC018736.1 BC065817.1 
    BX537813.1 

    24/37 DOTS entries (see all 37):

    DT.100646990  DT.100866267  DT.100646986  DT.449468  DT.97859725  DT.120995079  DT.100646983  DT.75169050 
    DT.100741545  DT.95232593  DT.101968325  DT.100030252  DT.91969720  DT.120995127  DT.91752373  DT.99930021 
    DT.97794041  DT.101985024  DT.40255740  DT.102834666  DT.120995156  DT.91870562  DT.99933106  DT.100030249 

    24/410 AceView cDNA sequences (see all 410):

    AW510551 CD370013 AI472537 AK002064 AW074023 AW872987 AW769165 AI285599 
    AL542887 AW960742 AI920869 BG287789 AI559820 BX953095 BM754201 BE855442 
    BM822942 BQ574386 BU630170 Z42918 AI859261 AA938513 AA133201 BM676988 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SPATS2L    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
    SP1:                                            -                           
    SP2:                    -                       -                           
    SP3:                                                                        


    ECgene alternative splicing isoforms for SPATS2L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPATS2L expression in normal human tissues (normalized intensities)      SPATS2L embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGCTTTTGTA
    SPATS2L Expression
    About this image


    SPATS2L expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Endothelium (Cardiovascular System)
             Endothelial-like cells ( Derivation and purification of endothelial precursor cells...

    See SPATS2L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPATS2L

    SOURCE GeneReport for Unigene cluster: Hs.120323
        SABiosciences Custom PCR Arrays for SPATS2L
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPATS2L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SPATS2L gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spats2l1 , 5 spermatogenesis associated, serine-rich 2-like1, 5 88.09(n)1
    89.59(a)1
      1 (28.85 cM)5
    671981  NM_001164566.11  NP_001158038.11 
     577741625 
    chicken
    (Gallus gallus)
    Aves SPATS2L1 spermatogenesis associated, serine-rich 2-like 72.91(n)
    68.89(a)
      424067  NM_001008474.1  NP_001008474.1 
    lizard
    (Anolis carolinensis)
    Reptilia SPATS2L6
    spermatogenesis associated, serine-rich 2-like
    61(a)
    1 ↔ 1
    1(117651476-117726934)


    ENSEMBL Gene Tree for SPATS2L (if available)
    TreeFam Gene Tree for SPATS2L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPATS2L gene
    SPATS22  
    18/65 SIMAP similar genes for SPATS2L using alignment to 16 protein entries:     SPS2L_HUMAN (see all proteins) (see all similar genes):
    AURA2    NFS1    SH3PXD2A    ZNF283    LOC100506792    LEPROTL1
    RUFY1    DCK    DCTN5    PHC3    TMEM14B    SPATS2
    RBBP4    APOD    BTBD2    ERBB2    PKN1    RBMS2

    SPATS2L for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3017 SNPs in SPATS2L are shown (see all 3017)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1922979051,2
    --201168624(+) CAATAC/TTGTCA 1 -- us2k10--------
    rs1836824631,2
    --201168668(+) TGTAAC/TTTTTC 1 -- us2k10--------
    rs556772331,2
    C,F--201168695(+) TCTGGT/CGAAAA 1 -- us2k17Minor allele frequency- C:0.44NA CSA WA EA 365
    rs2951511,2
    C--201168703(-) TGTTGG/ATGTTT 1 -- us2k111Minor allele frequency- A:0.01NA WA CSA EA 372
    rs1420480381,2
    C--201168728(+) ATTTTG/TTTTCT 1 -- us2k10--------
    rs1870354511,2
    --201168746(+) TTTCTA/GTCTCC 1 -- us2k10--------
    rs563265331,2
    C,F--201168758(+) TATAAT/CAATAG 1 -- us2k16Minor allele frequency- C:0.44NA CSA WA EA 363
    rs1914808931,2
    --201168796(+) TTATGC/TCTAAT 1 -- us2k10--------
    rs621795051,2
    C,F--201168851(+) TTTACA/GTGTTT 1 -- us2k12Minor allele frequency- G:0.13NA 122
    rs1828190481,2
    --201168866(+) AAGCAC/TATTAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SPATS2L (201170604 - 201346986 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for SPATS2L (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2677584CNV Deletion23128226
    esv2658982CNV Deletion23128226
    esv269068CNV Insertion20981092
    nsv507061CNV Insertion20534489
    esv268686CNV Insertion20981092
    esv1009509CNV Insertion20482838
    nsv213509CNV Insertion16902084
    nsv3107CNV Loss18451855
    nsv3108CNV Loss18451855
    nsv875706CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613817    OMIM disorders: --

    2 diseases for SPATS2L:    About MalaCards
    asthma    


    SPATS2L for disorders           About GeneDecksing

    Genetic Association Database (GAD): SPATS2L
    Human Genome Epidemiology (HuGE) Navigator: SPATS2L (4 documents)

    Export disorders for SPATS2L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPATS2L gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with SPATS2L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
    2. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    3. SGNP: an essential Stress Granule/Nucleolar Protein potentially involved in 5.8s rRNA processing/transport. (PubMed id 19005571)1, 2 Zhu C.H....Wright W.E. (2008)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Fine-mapping of restless legs locus 4 (RLS4) identifie s a haplotype over the SPATS2L and KCTD18 genes. (PubMed id 23054586)1 Pichler I....Pramstaller P.P. (2013)
    6. Genome-wide association analysis in asthma subjects id entifies SPATS2L as a novel bronchodilator response gene. (PubMed id 22792082)1 Himes B.E....Weiss S.T. (2012)
    7. A bead-based approach for large-scale identification o f in vitro kinase substrates. (PubMed id 22113938)1 Zhang M....Zou H. (2011)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Genetic associations of variants in genes encoding HI V-dependency factors required for HIV-1 infection. (PubMed id 21083371)4 Chinn L.W....O'Brien S.J. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26010 HGNC: 24574 AceView: DNAPTP6 Ensembl:ENSG00000196141 euGenes: HUgn26010
    ECgene: SPATS2L H-InvDB: SPATS2L

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPATS2L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SPATS2L gene:
    Search GeneIP for patents involving SPATS2L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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