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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPATS2L Gene

protein-coding   GIFtS: 48
GCID: GC02P201170

spermatogenesis associated, serine-rich 2-like
  Search for SPATS2L
in
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 Human Malady Compendium 
Biological research products
for SPATS2L    

Aliases
for SPATS2L gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Spermatogenesis Associated, Serine-Rich 2-Like1 2     DNA Polymerase-Transactivated Protein 62 3
DNAPTP61 2 3     DNA Polymerase Transactivated Protein 62
Stress Granule And Nucleolar Protein2 3     SPATS2-Like Protein2
SGNP2 3     

External Ids:    HGNC: 245741   Entrez Gene: 260102   Ensembl: ENSG000001961417   OMIM: 6138175   UniProtKB: Q9NUQ63   

Export aliases for SPATS2L gene to outside databases

Previous GC identifers: GC02P200881 GC02P193023


Summaries
for SPATS2L gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Gene Wiki entry for SPATS2L


Genomic Views
for SPATS2L gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SPATS2L
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SPATS2L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPATS2L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.1   Ensembl cytogenetic band:  2q33.1   HGNC cytogenetic band: 2q33.1

SPATS2L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPATS2L gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P201170:  view genomic region     (about GC identifiers)

Start:
 201,170,604 bp from pter      End:
 201,346,986 bp from pter
Size:
 176,383 bases      Orientation:
 plus strand

Proteins
for SPATS2L gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SPS2L_HUMAN, Q9NUQ6 (See protein sequence)
Recommended Name: SPATS2-like protein  
Size: 558 amino acids; 61729 Da
Subcellular location: Cytoplasm. Nucleus, nucleolus. Note=During oxidative stress as well as UV irradiation, energy
deprivation or heat shock, relocalizes to cytoplasmic stress granules. In the nucleus, found in structures lacking
NPM1
Sequence caution: Sequence=AAG22487.1; Type=Frameshift; Positions=92;
Secondary accessions: A8K381 B7WNZ7 Q53T22 Q8WV53 Q8WYG1 Q9NTW4
Alternative splicing: 2 isoforms:  Q9NUQ6-1   Q9NUQ6-2   

Explore the universe of human proteins at neXtProt for SPATS2L: NX_Q9NUQ6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NUQ6

    • SPATS2L Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001093892.1  NP_001093893.1  NP_001093894.1  NP_056350.2  

    ENSEMBL proteins: 
     ENSP00000406728   ENSP00000386336   ENSP00000351503   ENSP00000386931   ENSP00000386391  
     ENSP00000411294   ENSP00000405506   ENSP00000391467   ENSP00000353989   ENSP00000396109  
     ENSP00000398198   ENSP00000389908   ENSP00000390506   ENSP00000386730   ENSP00000386600  
     ENSP00000386310   ENSP00000402559   ENSP00000413142   ENSP00000413648   ENSP00000405751  
     ENSP00000387333  

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    Uscn Proteins for SPATS2L

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm IEA--
    GO:0043234protein complex ----


    SPATS2L for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for SPATS2L gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SPATS2L for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR009816 DUF1387
     IPR009060 UBA-like

    Graphical View of Domain Structure for InterPro Entry Q9NUQ6

    ProtoNet protein and cluster: Q9NUQ6

    UniProtKB/Swiss-Prot: SPS2L_HUMAN, Q9NUQ6
    Similarity: Belongs to the SPATS2 family


    Function
    for SPATS2L gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
    Products:            		miRTarBase miRNAs that target SPATS2L:
    hsa-mir-21 (MIRT004812)

    OriGene 3'-UTR Clone (see all 4): SPATS2L
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPATS2L
    8/99 QIAGEN miScript miRNA Assays for microRNAs that regulate SPATS2L (see all 99):
    hsa-miR-579 hsa-miR-607 hsa-miR-134 hsa-miR-632 hsa-miR-4325 hsa-miR-3613-3p hsa-miR-489 hsa-miR-3116
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPATS2L

    1 GenomeRNAi human phenotype for SPATS2L:
     Decreased p24 protein expressi 


    Pathways & Interactions
    for SPATS2L gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPATS2L

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SPATS2L (Q9NUQ63 ENSP000003515034) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    About this table

    Drugs & Compounds
    for SPATS2L gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPATS2L
    Search CenterWatch for drugs/clinical trials and news about SPATS2L / SPS2L 

    Transcripts
    for SPATS2L gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SPATS2L gene (4 alternative transcripts): 
    NM_001100422.1  NM_001100423.1  NM_001100424.1  NM_015535.2  

    Unigene Cluster for SPATS2L:

    Spermatogenesis associated, serine-rich 2-like
    Hs.120323  [show with all ESTs]
    Unigene Representative Sequence: NM_001100422
    18/27 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):
    ENST00000439084 ENST00000409718(uc002uvn.4 uc010fst.3 uc002uvo.4)
    ENST00000358677(uc010zhc.2) ENST00000409988(uc002uvp.4 uc002uvq.4)
    ENST00000409385 ENST00000439395 ENST00000444012 ENST00000451764 ENST00000360760
    ENST00000423749 ENST00000428692 ENST00000471601 ENST00000457757 ENST00000453663
    ENST00000409140(uc002uvr.4) ENST00000459656 ENST00000471533 ENST00000409397


    miRNA
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    8/99 QIAGEN miScript miRNA Assays for microRNAs that regulate SPATS2L (see all 99):
    hsa-miR-579 hsa-miR-607 hsa-miR-134 hsa-miR-632 hsa-miR-4325 hsa-miR-3613-3p hsa-miR-489 hsa-miR-3116
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene shRNA RFP: SPATS2L
    OriGene siRNA: SPATS2L
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPATS2L
    Clone
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    Additional cDNA sequence: 

    AF193059.1 AK002064.1 AK021816.1 AK024200.1 AK090703.1 AK090867.1 AK092917.1 AK290496.1 
    AK299223.1 AK300075.1 AK314561.1 AL110124.1 AY450394.1 BC010848.1 BC018736.1 BC065817.1 
    BX537813.1 

    24/37 DOTS entries (see all 37):

    DT.100646990  DT.100866267  DT.100646986  DT.449468  DT.97859725  DT.120995079  DT.100646983  DT.75169050 
    DT.100741545  DT.95232593  DT.101968325  DT.100030252  DT.91969720  DT.120995127  DT.91752373  DT.99930021 
    DT.97794041  DT.101985024  DT.40255740  DT.102834666  DT.120995156  DT.91870562  DT.99933106  DT.100030249 

    24/410 AceView cDNA sequences (see all 410):

    BM473473 AW510551 BF477612 BP334458 BU727748 BQ574386 AI828334 CK824794 
    AA827517 BE855442 AI862362 AI559820 AA448348 BX953095 AI344751 BF026314 
    BM828928 AW769165 BE000407 AK002064 BU727796 BE464650 AL110124 AA938513 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SPATS2L    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
    SP1:                                            -                           
    SP2:                    -                       -                           
    SP3:                                                                        


    ECgene alternative splicing isoforms for SPATS2L

    Expression
    for SPATS2L gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPATS2L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CGCTTTTGTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SPATS2L expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    N2/LSB/S/F8/CHIR-induced cells (Generation of midbra...)
    Posterior foregut-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SPATS2L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPATS2L

    SOURCE GeneReport for Unigene cluster: Hs.120323
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    In Situ
    Assay Products:     
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    Orthologs
    for SPATS2L gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for SPATS2L gene from 2/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SPATS2L1 spermatogenesis associated, serine-rich 2-like 72.91(n)
    68.89(a)    		   424067  NM_001008474.1  NP_001008474.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SPATS2L6
    		 --
    		 61(a)
    		 1 ↔ 1
    		 1(117684595-117726107)


    ENSEMBL Gene Tree for SPATS2L (if available)
    TreeFam Gene Tree for SPATS2L (if available) 

    Paralogs
    for SPATS2L gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPATS2L gene
    SPATS22  
    18/54 SIMAP similar genes for SPATS2L using alignment to 16 protein entries:     SPS2L_HUMAN (see all proteins) (see all similar genes):
    AURA2    NFS1    SH3PXD2A    ZNF283    LOC100506792    LEPROTL1
    RUFY1    DCK    DCTN5    PHC3    TMEM14B    SPATS2
    RBBP4    APOD    BTBD2    ERBB2    PKN1    RBMS2

    SPATS2L for paralogs           About GeneDecksing



    Genomic Variants
    for SPATS2L gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2477 NCBI SNPs in SPATS2L are shown (see all 2477)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1922979051,2
    		--201168624(+) CAATAC/TTGTCA 1 -- us2k10--------
    rs1836824631,2
    		--201168668(+) TGTAAC/TTTTTC 1 -- us2k10--------
    rs556772331,2
    		C,F,--201168695(+) TCTGGT/CGAAAA 1 -- us2k17Minor allele frequency- C:0.44NA CSA WA EA 365
    rs2951511,2
    		C,--201168703(-) TGTTGG/ATGTTT 1 -- us2k111Minor allele frequency- A:0.01NA WA CSA EA 372
    rs1420480381,2
    		--201168728(+) ATTTTG/TTTTCT 1 -- us2k10--------
    rs1870354511,2
    		--201168746(+) TTTCTA/GTCTCC 1 -- us2k10--------
    rs563265331,2
    		C,F,--201168758(+) TATAAT/CAATAG 1 -- us2k16Minor allele frequency- C:0.44NA CSA WA EA 363
    rs1914808931,2
    		--201168796(+) TTATGC/TCTAAT 1 -- us2k10--------
    rs621795051,2
    		C,--201168851(+) TTTACA/GTGTTT 1 -- us2k12Minor allele frequency- G:0.13NA 122
    rs1828190481,2
    		--201168866(+) AAGCAC/TATTAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SPATS2L (201170604 - 201346986 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for SPATS2L
         1 CNV: 50369
         2 Indels: 58956 50370

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    DNA2.0 Custom Variant and Variant Library Synthesis for SPATS2L

    Disorders / Diseases
    for SPATS2L gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SPATS2L for disorders           About MalaCards

    SPATS2L for disorders           About GeneDecksing

    OMIM gene information: 613817    OMIM disorders: --

    Human Genome Epidemiology (HuGE) Navigator: SPATS2L (4 documents)

    Export disorders for SPATS2L gene to outside databases

    Publications
    for SPATS2L gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPATS2L gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with SPATS2L)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
    2. SGNP: an essential Stress Granule/Nucleolar Protein potentially involved in 5.8s rRNA processing/transport. (PubMed id 19005571)1, 2 Zhu C.H....Wright W.E. (2008)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Genome-wide association analysis in asthma subjects id entifies SPATS2L as a novel bronchodilator response gene. (PubMed id 22792082)1 Himes B.E....Weiss S.T. (2012)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    8. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    9. Genome-Wide Association Study of Exercise Behavior in Dutch and American Adults. (PubMed id 19727025)1 DE Moor M.H....Deng H.W. (2009)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)

    External Searches for SPATS2L gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing SPATS2L gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26010 HGNC: 24574 AceView: DNAPTP6 Ensembl:ENSG00000196141 euGenes: HUgn26010
    ECgene: SPATS2L H-InvDB: SPATS2L

    Other Databases showing SPATS2L gene

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    Specialized Databases showing SPATS2L gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SPATS2L Pharmacogenomics, SNPs, Pathways

    Intellectual Property
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