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Aliases for SPATS2L Gene

Aliases for SPATS2L Gene

  • Spermatogenesis Associated Serine Rich 2 Like 2 3 5
  • Stress Granule And Nucleolar Protein 2 3 4
  • DNA Polymerase-Transactivated Protein 6 3 4
  • DNAPTP6 3 4
  • SGNP 3 4
  • Spermatogenesis Associated, Serine-Rich 2-Like 2
  • DNA Polymerase Transactivated Protein 6 2
  • SPATS2-Like Protein 3

External Ids for SPATS2L Gene

Previous GeneCards Identifiers for SPATS2L Gene

  • GC02P200881
  • GC02P201170
  • GC02P193023

Summaries for SPATS2L Gene

GeneCards Summary for SPATS2L Gene

SPATS2L (Spermatogenesis Associated Serine Rich 2 Like) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is SPATS2.

Gene Wiki entry for SPATS2L Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATS2L Gene

Genomics for SPATS2L Gene

Regulatory Elements for SPATS2L Gene

Enhancers for SPATS2L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F200402 1.7 FANTOM5 Ensembl ENCODE 15.8 +100.7 100652 8.2 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 YBX1 ZNF207 FOS ZNF263 SPATS2L PPIL3 KCTD18 FTCDNL1 AOX3P CLK1 BZW1 RNY4P34 LOC101927741
GH02F200252 1.4 Ensembl ENCODE 18.3 -52.7 -52696 1.9 PKNOX1 MLX CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 SPATS2L LOC101927687 GC02P200203
GH02F200339 1.2 Ensembl ENCODE 18.5 +34.5 34494 1.1 ATF1 MLX ZFP64 ARID4B DMAP1 SLC30A9 SP5 NFYC MXD4 MIER2 SPATS2L GC02P200374
GH02F200351 1.2 Ensembl ENCODE 17.7 +49.4 49384 7.0 HDAC1 ATF1 PKNOX1 FEZF1 CHAMP1 ZEB1 ZNF366 ETV6 FOS CREM SPATS2L AOX1 C2orf69 GC02P200374
GH02F200372 1 ENCODE 18 +72.7 72650 11.9 PKNOX1 ZFP64 FEZF1 YBX1 ZNF143 KLF13 JUNB TSHZ1 TBX21 SMARCA4 SPATS2L CFLAR C2orf69 LOC101927687 RNY4P34 LOC101927741
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPATS2L on UCSC Golden Path with GeneCards custom track

Promoters for SPATS2L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000605346 1319 3601 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207

Genomic Location for SPATS2L Gene

200,305,881 bp from pter
200,482,263 bp from pter
176,383 bases
Plus strand

Genomic View for SPATS2L Gene

Genes around SPATS2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATS2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATS2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATS2L Gene

Proteins for SPATS2L Gene

  • Protein details for SPATS2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SPATS2-like protein
    Protein Accession:
    Secondary Accessions:
    • A8K381
    • B4DRE6
    • B4DT67
    • B7WNZ7
    • Q53T22
    • Q8WV53
    • Q8WYG1
    • Q9NTW4

    Protein attributes for SPATS2L Gene

    558 amino acids
    Molecular mass:
    61729 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAG22487.1; Type=Frameshift; Positions=92; Evidence={ECO:0000305};

    Alternative splice isoforms for SPATS2L Gene


neXtProt entry for SPATS2L Gene

Post-translational modifications for SPATS2L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SPATS2L Gene

Domains & Families for SPATS2L Gene

Protein Domains for SPATS2L Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPATS2 family.
  • Belongs to the SPATS2 family.
genes like me logo Genes that share domains with SPATS2L: view

No data available for Gene Families for SPATS2L Gene

Function for SPATS2L Gene

Gene Ontology (GO) - Molecular Function for SPATS2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SPATS2L: view
genes like me logo Genes that share phenotypes with SPATS2L: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPATS2L Gene

Localization for SPATS2L Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPATS2L Gene

Cytoplasm. Nucleus, nucleolus. Note=During oxidative stress as well as UV irradiation, energy deprivation or heat shock, relocalizes to cytoplasmic stress granules. In the nucleus, found in structures lacking NPM1.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPATS2L gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SPATS2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IEA,IBA --
GO:0043234 protein complex IDA --
genes like me logo Genes that share ontologies with SPATS2L: view

Pathways & Interactions for SPATS2L Gene

SuperPathways for SPATS2L Gene

No Data Available

Interacting Proteins for SPATS2L Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000351503 Q9NUQ6-SPS2L_HUMAN for SPATS2L Gene via STRING IID

Gene Ontology (GO) - Biological Process for SPATS2L Gene


No data available for Pathways by source and SIGNOR curated interactions for SPATS2L Gene

Transcripts for SPATS2L Gene

Unigene Clusters for SPATS2L Gene

Spermatogenesis associated, serine-rich 2-like:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPATS2L Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1: -
SP2: - -

Relevant External Links for SPATS2L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPATS2L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPATS2L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SPATS2L Gene

This gene is overexpressed in Lung (62.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SPATS2L Gene

NURSA nuclear receptor signaling pathways regulating expression of SPATS2L Gene:


SOURCE GeneReport for Unigene cluster for SPATS2L Gene:

genes like me logo Genes that share expression patterns with SPATS2L: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SPATS2L Gene

Orthologs for SPATS2L Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPATS2L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPATS2L 34 35
  • 99.88 (n)
(Canis familiaris)
Mammalia SPATS2L 34 35
  • 91.76 (n)
(Bos Taurus)
Mammalia SPATS2L 34 35
  • 90.72 (n)
(Rattus norvegicus)
Mammalia Spats2l 34
  • 87.97 (n)
(Mus musculus)
Mammalia Spats2l 34 16 35
  • 87.96 (n)
(Monodelphis domestica)
Mammalia SPATS2L 35
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia SPATS2L 35
  • 51 (a)
(Gallus gallus)
Aves SPATS2L 34 35
  • 72.59 (n)
(Anolis carolinensis)
Reptilia SPATS2L 35
  • 60 (a)
Species where no ortholog for SPATS2L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPATS2L Gene

Gene Tree for SPATS2L (if available)
Gene Tree for SPATS2L (if available)

Paralogs for SPATS2L Gene

Variants for SPATS2L Gene

Sequence variations from dbSNP and Humsavar for SPATS2L Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10168564 -- 200,430,358(+) AAAGA(C/T)AATCA intron-variant
rs10171528 -- 200,396,035(+) aaaaa(A/T)atata intron-variant
rs10177991 -- 200,477,661(+) ACGGA(A/G)ATTTA nc-transcript-variant, upstream-variant-2KB, reference, missense
rs10178090 -- 200,477,772(+) CAGAA(A/G)ACAGC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs10182479 -- 200,396,033(+) aaaaa(A/T)atata intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPATS2L Gene

Variant ID Type Subtype PubMed ID
esv1009509 CNV insertion 20482838
esv2658982 CNV deletion 23128226
esv2677584 CNV deletion 23128226
esv2763058 CNV loss 21179565
esv2763627 CNV loss 21179565
esv3332672 CNV insertion 20981092
esv3349715 CNV insertion 20981092
esv3448478 CNV insertion 20981092
esv3593955 CNV loss 21293372
esv3593957 CNV loss 21293372
esv3893530 CNV loss 25118596
nsv1072060 CNV deletion 25765185
nsv1118890 CNV deletion 24896259
nsv213509 CNV insertion 16902084
nsv3107 CNV deletion 18451855
nsv3108 CNV deletion 18451855
nsv507061 OTHER sequence alteration 20534489
nsv517769 CNV gain+loss 19592680
nsv819248 CNV gain 19587683

Variation tolerance for SPATS2L Gene

Residual Variation Intolerance Score: 35.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.85; 83.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPATS2L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATS2L Gene

Disorders for SPATS2L Gene

Relevant External Links for SPATS2L

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SPATS2L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPATS2L Gene

Publications for SPATS2L Gene

  1. SGNP: an essential stress granule/nucleolar protein potentially involved in 5.8s rRNA processing/transport. (PMID: 19005571) Zhu C.H. … Wright W.E. (PLoS ONE 2008) 2 3 4 64
  2. Genome-wide association analysis in asthma subjects identifies SPATS2L as a novel bronchodilator response gene. (PMID: 22792082) Himes B.E. … Weiss S.T. (PLoS Genet. 2012) 2 3 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64

Products for SPATS2L Gene

Sources for SPATS2L Gene

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