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Aliases for SPATS2L Gene

Aliases for SPATS2L Gene

  • Spermatogenesis Associated Serine Rich 2 Like 2 3
  • Stress Granule And Nucleolar Protein 2 3 4
  • Spermatogenesis Associated, Serine-Rich 2-Like 2 3
  • Spermatogenesis Associated, Serine Rich 2 Like 3 5
  • DNA Polymerase Transactivated Protein 6 2 3
  • DNA Polymerase-Transactivated Protein 6 3 4
  • DNAPTP6 3 4
  • SGNP 3 4

External Ids for SPATS2L Gene

Previous GeneCards Identifiers for SPATS2L Gene

  • GC02P200881
  • GC02P201170
  • GC02P193023

Summaries for SPATS2L Gene

GeneCards Summary for SPATS2L Gene

SPATS2L (Spermatogenesis Associated Serine Rich 2 Like) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is SPATS2.

Gene Wiki entry for SPATS2L Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATS2L Gene

Genomics for SPATS2L Gene

Regulatory Elements for SPATS2L Gene

Promoters for SPATS2L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SPATS2L on UCSC Golden Path with GeneCards custom track

Genomic Location for SPATS2L Gene

Chromosome:
2
Start:
200,305,881 bp from pter
End:
200,482,263 bp from pter
Size:
176,383 bases
Orientation:
Plus strand

Genomic View for SPATS2L Gene

Genes around SPATS2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATS2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATS2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATS2L Gene

Proteins for SPATS2L Gene

  • Protein details for SPATS2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUQ6-SPS2L_HUMAN
    Recommended name:
    SPATS2-like protein
    Protein Accession:
    Q9NUQ6
    Secondary Accessions:
    • A8K381
    • B4DRE6
    • B4DT67
    • B7WNZ7
    • Q53T22
    • Q8WV53
    • Q8WYG1
    • Q9NTW4

    Protein attributes for SPATS2L Gene

    Size:
    558 amino acids
    Molecular mass:
    61729 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG22487.1; Type=Frameshift; Positions=92; Evidence={ECO:0000305};

    Alternative splice isoforms for SPATS2L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPATS2L Gene

Proteomics data for SPATS2L Gene at MOPED

Post-translational modifications for SPATS2L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SPATS2L Gene

Domains & Families for SPATS2L Gene

Protein Domains for SPATS2L Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NUQ6

UniProtKB/Swiss-Prot:

SPS2L_HUMAN :
  • Belongs to the SPATS2 family.
Family:
  • Belongs to the SPATS2 family.
genes like me logo Genes that share domains with SPATS2L: view

No data available for Gene Families for SPATS2L Gene

Function for SPATS2L Gene

genes like me logo Genes that share phenotypes with SPATS2L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPATS2L Gene

Localization for SPATS2L Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPATS2L Gene

Cytoplasm. Nucleus, nucleolus. Note=During oxidative stress as well as UV irradiation, energy deprivation or heat shock, relocalizes to cytoplasmic stress granules. In the nucleus, found in structures lacking NPM1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPATS2L Gene COMPARTMENTS Subcellular localization image for SPATS2L gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SPATS2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with SPATS2L: view

Pathways & Interactions for SPATS2L Gene

SuperPathways for SPATS2L Gene

No Data Available

Interacting Proteins for SPATS2L Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000351503%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000376076%0d%0a9606.ENSP00000217244%0d%0a
Selected Interacting proteins: Q9NUQ6-SPS2L_HUMAN ENSP00000351503 for SPATS2L Gene via I2D STRING

Gene Ontology (GO) - Biological Process for SPATS2L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SPATS2L Gene

Drugs & Compounds for SPATS2L Gene

No Compound Related Data Available

Transcripts for SPATS2L Gene

Unigene Clusters for SPATS2L Gene

Spermatogenesis associated, serine-rich 2-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPATS2L Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1: -
SP2: - -
SP3:

Relevant External Links for SPATS2L Gene

GeneLoc Exon Structure for
SPATS2L
ECgene alternative splicing isoforms for
SPATS2L

Expression for SPATS2L Gene

mRNA expression in normal human tissues for SPATS2L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SPATS2L Gene

This gene is overexpressed in Lung (62.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPATS2L Gene



SOURCE GeneReport for Unigene cluster for SPATS2L Gene Hs.120323

genes like me logo Genes that share expression patterns with SPATS2L: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SPATS2L Gene

Orthologs for SPATS2L Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPATS2L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SPATS2L 35
  • 90.72 (n)
  • 93.09 (a)
SPATS2L 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPATS2L 35
  • 91.76 (n)
  • 93.82 (a)
SPATS2L 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spats2l 35
  • 87.96 (n)
  • 89.03 (a)
Spats2l 16
Spats2l 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SPATS2L 35
  • 99.88 (n)
  • 100 (a)
SPATS2L 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spats2l 35
  • 87.97 (n)
  • 90.48 (a)
oppossum
(Monodelphis domestica)
Mammalia SPATS2L 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPATS2L 36
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPATS2L 35
  • 72.59 (n)
  • 68.57 (a)
SPATS2L 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPATS2L 36
  • 60 (a)
OneToOne
Species with no ortholog for SPATS2L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPATS2L Gene

ENSEMBL:
Gene Tree for SPATS2L (if available)
TreeFam:
Gene Tree for SPATS2L (if available)

Paralogs for SPATS2L Gene

Paralogs for SPATS2L Gene

genes like me logo Genes that share paralogs with SPATS2L: view

Variants for SPATS2L Gene

Sequence variations from dbSNP and Humsavar for SPATS2L Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs159320 -- 200,323,052(-) GAGAT(C/T)TGAAG intron-variant
rs159321 -- 200,319,990(-) TGCAA(C/T)TGATA intron-variant
rs159322 -- 200,318,736(-) TATCA(C/G)TGAGT intron-variant
rs159430 -- 200,370,064(-) AATCC(C/G/T)GGCCA intron-variant
rs192680 -- 200,364,167(+) ATCCT(C/T)CTCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPATS2L Gene

Variant ID Type Subtype PubMed ID
nsv3107 CNV Loss 18451855
nsv875706 CNV Gain 21882294
esv268686 CNV Insertion 20981092
nsv507061 CNV Insertion 20534489
esv1009509 CNV Insertion 20482838
nsv213509 CNV Insertion 16902084
nsv3108 CNV Loss 18451855
esv2677584 CNV Deletion 23128226
esv269068 CNV Insertion 20981092
esv2658982 CNV Deletion 23128226
nsv819248 CNV Gain 19587683
nsv517769 CNV Gain+Loss 19592680
nsv875707 CNV Gain 21882294

Variation tolerance for SPATS2L Gene

Residual Variation Intolerance Score: 35.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.85; 83.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPATS2L Gene

HapMap Linkage Disequilibrium report
SPATS2L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATS2L Gene

Disorders for SPATS2L Gene

Relevant External Links for SPATS2L

Genetic Association Database (GAD)
SPATS2L
Human Genome Epidemiology (HuGE) Navigator
SPATS2L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPATS2L

No disorders were found for SPATS2L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPATS2L Gene

Publications for SPATS2L Gene

  1. SGNP: an essential stress granule/nucleolar protein potentially involved in 5.8s rRNA processing/transport. (PMID: 19005571) Zhu C.H. … Wright W.E. (PLoS ONE 2008) 2 3 4 67
  2. Genome-wide association analysis in asthma subjects identifies SPATS2L as a novel bronchodilator response gene. (PMID: 22792082) Himes B.E. … Weiss S.T. (PLoS Genet. 2012) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. (PMID: 24952745) Arking D.E. … Newton-Cheh C. (Nat. Genet. 2014) 3
  5. Sleep quality, BDNF genotype and gene expression in individuals with chronic abdominal pain. (PMID: 25358868) Reddy S.Y. … Henderson W.A. (BMC Med Genomics 2014) 3

Products for SPATS2L Gene

Sources for SPATS2L Gene

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